LOCUS       c00055_gnlPro..        14763 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|OBMANACO_55.
ACCESSION   c00055_gnlPro..
VERSION     c00055_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-07 06:22:58
            Original ID  :: gnl|Prokka|OBMANACO_55
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14763
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14763
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[124:4763]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      125..4763
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..14763
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14763
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             125..529
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Glyoxalase_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg55_1"
                     /sec_met_domain="Glyoxalase_4 (E-value: 2.8e-24, bitscore:
                     75.4, seeds: 51, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKISHIEHLGIAVKSIEEALPYYENVLGLKCYNIETVEDQKVRTA
                     FLKVGDTKIELLEPTCPESTIAKFIENKGAGVHHVAFAIEDGVANALAEAESKEIRLID
                     KAPRKGAEGLNIAFLHPKSTLGVLTELCEH"
     CDS             655..2208
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Btheta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg55_2"
                     /sec_met_domain="CT_Btheta (E-value: 2.6e-291, bitscore:
                     955.9, seeds: 72, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNQLEKVKELIELRAQARLGGGEKAIEKQHAKGKYTARERIAQL
                     LDEGSFEELDMFVQHRCTNFGQEKKHFLGDGVVTGYGTIEGRLVYVFAQDFTVFGGSLS
                     ETMAQKICKVMDMAMKMGAPVIGINDSGGARIQEGINALSGYAEIFQRNIMASGVIPQI
                     SGIFGPCAGGAVYSPALTDFTLMTEGTSYMFLTGPAVVKTVTGEDVSQEDLGGASVHAS
                     KSGVTHFTAETGEEGLAIIRKLLSFIPQNNLEEAPLVNCTDPIDRMDDLLNEIIPDSPN
                     KPYDMYEVIGAIIDNGEFLEVQKDYAKNLIIGFARMNGQSVGVVANQPKYLAGVLDSNA
                     SRKGARFVRFCDAFNIPLVTLVDVPGFLPGTGQEYNGVILHGAKLLYAYGEATVPKVTV
                     TLRKSYGGSHIVMSCKQLRGDMNYAWPTAEIAVMGGAGAVAVLYAKEAKDQENPAQFLA
                     DKEAEYTKLFANPYNAAKYGYIDDVIEPRNTRFRVIRALQQLQTKKLTNPAKKHGNIPL
                     "
     CDS             2229..3143
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg55_3"
                     /sec_met_domain="OAD_gamma (E-value: 8.1e-16, bitscore:
                     48.3, seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKKRIGIFIALLAMVCMGLRAQSATSLRINEVLVVNDQNYQDDY
                     GLHNAWIEIFNTSFASVNLEGCFLTNDKNNPTKYPIPKGDVLTLIKPRQHALFWADGMP
                     NRGTFHVNFTLDPNKENYIALYDSNGKTLIDEVTIPAGQLADRSYAREKDGSANWVVKG
                     EGEHSYVTPSTNNMTIDKNPKIENFKKHDSIGIGMAIIAMSVVFIGLVLLYLSFKAVGN
                     AAVRLGKKNAMKATGITDKTEAKEKNLGSHTGEETAAIAMALHEYLNDAHDVEDMILTI
                     NKVKRTYSPWSSKIYTLRQTPKR"
     CDS             3169..3600
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 69.7; E-value:
                     4.8e-22)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg55_4"
                     /sec_met_domain="Biotin_lipoyl (E-value: 1e-22, bitscore:
                     69.7, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKQYKYKINGNLYNVTVNDVEDNIANVEVNGTSYKVELDKPVKAA
                     PKPVTRPAAAPKTETGAPVVTKQPTASKKDGVKSPLPGVILDIKVKEGDTVKRGQTIII
                     LEAMKMENNINANKDGKVAEIKVNKGDSVLEGTDLVIIE"
     CDS             3603..4763
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg55_5"
                     /sec_met_domain="OAD_beta (E-value: 3e-154, bitscore:
                     502.9, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGDFVSFLGNNLVDFWGYTGFANATPGHLFMLLIGLFFIYLAIAK
                     EFEPMLLIPIGFGILIGNIPFNMEAGLKVGIYEEGSVLNILYQGVTSGWYPPLIFLGIG
                     AMTDFSALISNPKLMLIGAAAQFGIFGAYIIALLIGFEPNQAGAIGIIGGADGPTAIFL
                     SSKLAPNLMGAIAVSAYSYMALVPVIQPPIMRALTTKHERLIRMKPPRIVSHTEKVIFP
                     IVGLLLTCFLVPSGLPLLGMLFFGNLLKESGVTRRLANTASGPLIDVITILLGLTVGAS
                     TQASQFLTWDSILIFILGAFSFIIATASGVMFVKFFNLFLKKGNKINPLIGNAGVSAVP
                     DSARISQVIGLEYDPTNYLLMHAMGPNVAGVIGSAVAAGILLGFLM"
     CDS             4912..6243
                     /locus_tag="ctg55_6"
                     /transl_table=11
                     /translation="MRTRTMKPLFLIFCLCLSPLLMGQNQNKIQEAMANYDYETAVELI
                     NKEPPTIPLLMQKAKALKGIGSNAEALRSIRQVIAEDSTNQQAHIEAAECCKAMAKYND
                     ALDYYRKAISLNPKNKYARLQFINLLCNTKNYAEAFGESSMMSETDSSAVVLHLQAQSL
                     EGMQQILPAIGCYEVIQDKYPDDYLAAAKLGNLNIVAGYPEYAIQATERYRERDSTNLI
                     VNQQNALAYCHAEQYPTAIKRYEKLCQQGDSSTQTLYYLGVSYYADEYYYEAHACFSKL
                     QKEMEENPNLLYYLGRCCAKTSWKKEGIEHLEKAIELTIPKDSTMIRLYKGLVDCCKLA
                     QDTPKQIQALRELYKYDKTNHKLLYDIAWNYSYQLKDNKSAERYLQAFLKTRKANARKE
                     EPVSEKGELVLGLENYYNAAENWLKDLQKEKFFKEGIPLESQKQ"
     CDS             6256..7548
                     /locus_tag="ctg55_7"
                     /transl_table=11
                     /translation="MKHWILLLYLGFSVMLRAQNTASVQEAMANYDYKTVIRLIDEESA
                     SPQLLIQKAKALKGLGRTAEALSTLQHIIIELPENQQALVEAAECCRQLSKFNEALGYY
                     RKVMELNPEHIYAHLQYTRLLYNYQRYGDALRESIALARKDSSATVLRLMAESMEGASM
                     PVESMFCYLSIIRKYPSDYLSVAKLGSIFNTMKDYKGAIALTEAYRRTDSTNVEVNRQN
                     ALAYCLRKEYPTAIKRYQDLTARGDSTLLTCYYLGVSYYATKEYYKARDWLLKAKSCQS
                     PGANLLYYLGRSCSKTLWKQEGIGYLNQAIALTIPADSIMERLYSGLADCYRQTKQTRD
                     QIKATKEQYKYAPDKHILLYNLAFLSDKIGDTKATEHYLQAFLRTKSKQNAVLQQPDDD
                     EEEPAPYIDYYKSATNKLESIRKEKFLKGEK"
     CDS             8008..9858
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Alpha-amylase"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg55_8"
                     /sec_met_domain="Alpha-amylase (E-value: 7.1e-64, bitscore:
                     206.2, seeds: 19, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKLLLLLGSFLLSLTTYAAMNISKIDPPFWFTGMNNPELQLMVY
                     GEGIGQASVSVNYPGVSLSSVVKLESNNYLLVYLHLDKEVKPGKMPITFTVGKKKLVKE
                     YELKARSKAGVDHKGFDASDALYLLMPDRFANGNPDNDRIEGMAEYKVDRNDPNARHGG
                     DLAGIEQNLDYFTDLGVTALWFTPVLENNMKGGSYHGYATTDYYKVDPRFGTNEEYRSL
                     IAKAHNRGIKVVMDMIFNHCGVEHPWIKDMPSKDWFNHADFKNNFVQTSYKLTPHVDPY
                     ASEYDFDQMNNGWFVEAMPDLNQKNPHVYKYLLQNSLWWIEYADIDGIRMDTYPYADYD
                     AMSNWMKELNEEYPNYNTVGETWVTEPAYTAWWQKDSKLSAPRNSHLKTVMDFSFFDKV
                     NTAKNEQTDTWFKGLDRVYNNFVYDYLYPNPASVLAFIENHDTDRFLGEGENLDMLKQA
                     STLLLTTRRIPQLYYGTEVMMNGVKSKSDGYVRKDFPGGWADDKENALTPEGRTRLQNE
                     SYNFYRNLLNWRKGNDVIAKGSMKQFMVQHGVYAYARQYKGKTVFVLLNGTDKEVKLPL
                     KYYAEVLKDKTQGKDVISGKVTTLNEELTMAPRQSMVIEL"
     CDS             10016..10456
                     /locus_tag="ctg55_9"
                     /transl_table=11
                     /translation="MTNNESERELVLQTLRTWMAFRQAVQRVLKRHNVDMTFEMLQVMN
                     CLWNKQGISQQSLAEKTAKDKACLTNLINNLEKKNWVIRKEGPSDRRNRLIFLTPQGEE
                     LALTVKPLINDIYAQTGTEMEASRITECIEDLKRLHEVLNEI"
     CDS             10469..11536
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Biotin_lipoyl_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg55_10"
                     /sec_met_domain="Biotin_lipoyl_2 (E-value: 1.2e-09,
                     bitscore: 27.7, seeds: 52, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTRQIKLKQLRRLKFRNIFLNTVCILLALAGISWTVNYFWKYAR
                     YEITNDAVVDQYIAPLNIRIPGYIKEVRFTEHQYVHASDTLLILDDREYRIRLKDAEAA
                     LMDALGSKEVLNSGIRTSGVNVAVQEANIAETLARLSQQEAELNRYTRLLKKQAVSQQD
                     YELAKANFEATRARYNALLRQKEAAQSQYSETSKRSTGAEANILRKEADLEMARLNLSY
                     TVVTAPYDGYTGRRTLEPGQFVQGGQTLSYLVRGNDKWVTANYKETQIAHIYIGQKVRI
                     KVDAFSGRTFHGTVTAISEATGSKYSLVPTDNSAGNFVKVQQRIPVRIDLNDASPEEME
                     CLRAGMMVETEAVRP"
     CDS             11541..13136
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MFS_1"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg55_11"
                     /sec_met_domain="MFS_1 (E-value: 9e-15, bitscore: 44.1,
                     seeds: 192, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVKLNLPTRPWVPQWLGIVTMFIVIFPITLLNGAYTGSMVEVSNT
                     LGVLSEDITMAYYSASVGMAVAYPIVPKIRTIATPKTLLLTDLLLQIFFSLVCAKTGSM
                     DVIMVCSFCMGFLKAFVMLEFIILIRPLFSPKNVRSEFYAYFYPIVFSGGQLSMAITAQ
                     LAYHYQWQHMYYFVTILLLIAILFVICFFRYARRPMHIPFKEMDGRSMFIIATAFLLTL
                     YTFTYGKTLDWFASPKIRVYVFVIPLLIALFIHRQRTQGKPFVSLKPLFLHKSIIGYGF
                     MVLTMFLTATSSLVTNYMNSIIRVDSIHANSLSLWLLPGYVVGAVICFWWFRWQRWRFR
                     FLISGGMFCYVIYLAILYFGITPYGTYEMLYLPILFRGVGMMVIFIAFGVFVVEDLDPR
                     LTLSNAFFLISFRSVLAPVLSASFFNNMLYYLQAKGMNILSENMTLTNPLAEQKYNQAL
                     SNALAQGHEFGEAGQLAANSLYSTLQQQSLLLALKTLIGYVLILALVIAVIAAFIPFHK
                     TLKVAVVKTGDDMV"
     CDS             complement(13231..14235)
                     /locus_tag="ctg55_12"
                     /transl_table=11
                     /translation="MVNYKDLGLVNTRDMFAKAIKGGYAIPAFNFNNMEQMQAIIKAAV
                     ETKSPVILQVSKGARQYANATLLRYMAQGAVEYAKELGCKNPEIVLHLDHGDTFETCKS
                     CIDSGFSSVMIDGSHLPYDENVALTKKVVEYAHQFDVTVEGELGVLAGVEDEVSSDHHT
                     YTEPDEVVDFVTKTGCDSLAISIGTSHGAYKFTPEQCHIDPKTGRMVPPPLAFDVLDGV
                     MKELPGFPIVLHGSSSVPEEEVATINQFGGALKAAIGIPEEELRKAAKSAVCKINIDSD
                     SRLAMTAAIRKVFAEKPAEFDPRKYLGPARDNMEKLYKHKIINVLGSDNKLAE"
ORIGIN
        1 ttaaaccttt tttcaccata attaattgca gataaattta tttattaaac aataattgat
       61 tttatttgtg atgttttata ccattccgaa aagacgatta ataccaaaat ttaaaaatat
      121 agttatgaag atttcacaca ttgaacattt gggcattgcc gtaaaaagta tcgaagaagc
      181 ccttccgtat tatgaaaacg ttttaggttt gaaatgctac aacatcgaaa ctgtagaaga
      241 tcaaaaagta agaacagcct tcctaaaagt aggtgatacc aaaatcgaat tactggaacc
      301 cacatgtccg gaaagtacca tcgcgaaatt catcgaaaac aaaggtgcag gtgttcatca
      361 cgtggcattc gccattgaag acggcgtagc caatgcccta gccgaagccg aaagcaaaga
      421 gatccgcctg atcgacaaag ctccgcgcaa aggtgccgaa ggcctgaaca ttgctttcct
      481 tcacccgaaa tcaactctgg gcgtactgac agaactctgc gaacactaaa aagatgtacg
      541 attcggacga tccgcgccac ggacaaacgg aatttttctt tgcattaaat tccccatccg
      601 ggttgtcaat cgtccggttg taaatattat aaccctttaa attaagaaaa actcatgagt
      661 aaccagcttg aaaaagtaaa agagcttatt gaacttcgtg ctcaggctcg tttaggtggt
      721 ggcgaaaagg ctattgaaaa acaacacgcc aaaggcaaat atacagcccg cgagcgtatt
      781 gcacagttgc ttgacgaagg tagtttcgaa gaactggata tgtttgttca acacagatgt
      841 accaatttcg gacaagagaa aaaacatttc ctcggcgacg gtgtggtaac cggttatgga
      901 acgatagaag gtagattagt atatgttttc gcacaagatt tcacagtatt cggtggttca
      961 ctgtcggaaa ccatggcaca aaagatctgt aaagtaatgg atatggccat gaagatgggt
     1021 gcccctgtca tcggtatcaa cgactcgggt ggcgcacgta ttcaggaagg catcaacgcc
     1081 ctgtccggtt atgctgaaat cttccagcgc aacatcatgg cttcgggtgt cattccacag
     1141 atttcaggta ttttcggtcc gtgtgccggc ggtgcggttt actctcccgc cctgacagac
     1201 ttcacgctga tgacggaagg tacatcttac atgttcctca ccggaccggc tgttgtgaaa
     1261 acagtaacgg gtgaagacgt gtctcaggaa gatctgggtg gtgcaagcgt acatgccagc
     1321 aagtccggtg taactcactt cactgccgaa accggtgaag aaggtctggc gattattcgc
     1381 aagcttctca gctttattcc gcaaaacaac ctggaagaag ctccattggt gaactgtacc
     1441 gaccccatcg accgtatgga cgacctgctg aacgagatca tccccgacag cccgaacaaa
     1501 ccgtacgata tgtacgaagt gatcggcgcc atcatcgata acggagaatt cctggaagta
     1561 cagaaagact atgcgaaaaa tcttattatc ggttttgccc gtatgaacgg acagtcggta
     1621 ggtgtggttg ccaatcagcc taaatacctc gccggagtac tcgacagcaa tgcttcacgc
     1681 aaaggtgcac gcttcgttcg cttctgcgac gcattcaaca ttccgctggt gacattggta
     1741 gacgttccgg gattccttcc gggtacgggt caggaatata atggtgtaat cctgcacgga
     1801 gccaagttgc tgtacgctta tggtgaagcc actgtgccca aggtaactgt taccctgcgt
     1861 aaatcttacg gtggttcgca catcgtaatg agttgcaagc aactccgcgg tgacatgaac
     1921 tatgcatggc cgacagccga aatcgccgta atgggaggtg ccggtgcagt agcggtattg
     1981 tatgccaaag aagctaaaga tcaggaaaac cctgctcaat tcctggcaga caaggaagcc
     2041 gagtacacta aactgttcgc caacccgtac aatgcagcca aatacggtta catcgacgac
     2101 gttatcgaac cgagaaacac tcgtttccgc gtgatccgcg ccctgcaaca gctgcagacc
     2161 aaaaaattaa ccaaccctgc taaaaagcac ggtaatattc cattgtaaca aattaaacat
     2221 cgattgttat gaataagaaa agaatcggga tatttatcgc tctgctggca atggtttgca
     2281 tggggctcag ggcgcaaagt gccaccagtc tgagaatcaa tgaggttttg gtcgtcaacg
     2341 accagaacta tcaggatgac tacggactgc acaatgcgtg gatagagata ttcaacacct
     2401 ctttcgcttc tgtaaatctg gaaggttgct ttctgacgaa cgataaaaac aatccgacca
     2461 aatatcctat tcccaaaggc gacgtgctga ctctgatcaa gccgcgccaa catgctttgt
     2521 tctgggcaga cggaatgcct aaccggggta cgttccacgt gaactttacg ctcgacccga
     2581 acaaagagaa ttacattgct ttgtatgact ctaacggtaa aactctgatt gacgaagtaa
     2641 ccatacccgc cggtcagctt gccgaccgtt catacgctcg cgaaaaagac ggaagtgcca
     2701 actgggtagt aaaaggtgaa ggagaacaca gctatgtcac tccgagcacc aacaatatga
     2761 ctatcgacaa aaacccgaag atcgagaact tcaagaaaca cgactctatc ggtatcggta
     2821 tggccatcat cgccatgtcg gtcgtattca taggtttggt actcttgtat ctttcattca
     2881 aggcggtagg taacgcagct gtcagactgg gtaagaaaaa tgcgatgaaa gccaccggta
     2941 tcaccgacaa gacggaagcg aaggaaaaga acctgggtag ccacacaggt gaagaaaccg
     3001 ccgcgatcgc catggctttg catgaatacc tgaatgacgc tcacgacgtt gaagacatga
     3061 ttttgactat caacaaagtg aaacgcacct actcaccctg gagttcgaag atctacacac
     3121 tgcgtcagac tccgaaaaga taattactaa ccctaataaa atgaagcaat gaaacaatat
     3181 aaatataaaa tcaacggcaa cctttacaac gttacagtga acgatgtaga agataacata
     3241 gccaacgttg aagtgaacgg aacctcttat aaagtagagt tggacaagcc tgtcaaagcc
     3301 gctccgaaac cggtgacccg tccggcagcc gctccgaaaa cggaaacagg tgctccggta
     3361 gtaaccaaac aaccgacagc ttccaaaaaa gacggtgtga aatctccgct tccgggcgtt
     3421 atcctcgaca taaaagtgaa agaaggggat accgtgaaga gaggccagac gatcatcatc
     3481 cttgaggcta tgaagatgga aaacaacatc aatgccaata aagacggaaa agtagcagaa
     3541 attaaagtta ataaaggaga ttctgtactt gaaggtacag acctcgtaat cattgaataa
     3601 ttatgggaga tttcgtatca ttcttaggga ataaccttgt tgacttctgg ggatacaccg
     3661 gttttgcgaa cgcgacaccc ggacatcttt tcatgttgct aatcggtctc ttctttatct
     3721 accttgccat agccaaagaa tttgaaccga tgctgctgat ccccattggc ttcggtattc
     3781 tgatcggtaa tattccattc aatatggaag ccggattaaa agtgggtatt tacgaagaag
     3841 gttcggtact gaacatcctt tatcaaggag taacctccgg ctggtatccg ccgctcattt
     3901 tcctgggtat cggagccatg acggacttct cggcgctgat ctccaacccc aaattgatgc
     3961 tgatcggagc tgccgcgcaa ttcggtatct tcggcgcgta tatcattgcc ctgctcattg
     4021 ggttcgaacc caaccaggcg ggtgctatcg gtatcattgg cggtgccgac ggaccgacgg
     4081 ccatcttcct ttcgtccaaa ctggctccca acctgatggg tgccatcgct gtgtcagcct
     4141 attcttacat ggcgctggtg ccggtgatac agccacctat catgcgtgcg ctaaccacca
     4201 aacacgagcg tctgatccgc atgaaaccac cgagaatcgt atcgcatacg gaaaaagtaa
     4261 tcttccccat cgtgggtctg ttgcttacat gcttcctggt tccttcgggt ctgcctttgc
     4321 tgggtatgct gttcttcggt aatcttctga aagaaagtgg agtaacccgt cgtttggcaa
     4381 atacggccag tggtccgttg atcgatgtga tcactatcct gttgggactg actgtgggag
     4441 cttctaccca agcttcacaa ttcctcacct gggattctat cttgatcttt atcctcggtg
     4501 cattctcttt catcatcgca acagcgtcag gtgtcatgtt tgtcaaattc ttcaatttat
     4561 tcttgaagaa aggcaataag atcaatccgc tgatcggtaa tgcaggtgta tccgccgtac
     4621 ccgattcagc acgtatttca caggtaatcg gtttggaata tgatccgacc aactatctgc
     4681 tgatgcacgc catgggtcct aacgtagcgg gggttatcgg ttcggctgta gctgccggta
     4741 tcctgctcgg attcctcatg taaacgacat ttttttcatt agtaaagtag acgtccttct
     4801 tttcgcaaag aagggcgtct tttttttgcg ttaatctatc taaaagatat tacgaaactt
     4861 tcgtagaatg gatattttta ctaacttgcg gacaataaaa caatacgtcc tatgagaaca
     4921 agaacaatga aaccactctt ccttattttc tgtctttgcc tcagtcccct actgatgggc
     4981 cagaatcaaa acaaaattca ggaagcaatg gcaaactatg actacgagac tgccgttgaa
     5041 ctgataaaca aggaacctcc caccatccca ctgttaatgc agaaagcaaa agccctgaaa
     5101 ggaatcggca gcaatgcgga agctctacgt tccatccgcc aagtgatagc ggaagactcc
     5161 accaaccaac aggcacacat cgaagcagcg gaatgctgta aagcaatggc caagtacaac
     5221 gatgcgctgg actactaccg gaaagccatc agcctgaatc ccaaaaacaa gtatgcccgt
     5281 ttgcaattca tcaacctgct ttgcaacacc aaaaactatg ctgaggcttt tggagaaagt
     5341 tcaatgatgt ccgaaacgga tagttcggcc gtagtgctcc acctacaggc ccaaagcctt
     5401 gaagggatgc aacagatact accggctatc ggttgctatg aagtcattca ggataaatat
     5461 ccggacgatt atctggctgc ggccaaactc ggaaacctga acattgtagc tggatatccc
     5521 gaatatgcca tccaagctac cgaacgctat agggaacggg actccaccaa cctgattgtc
     5581 aaccagcaaa acgctctcgc ctactgccac gccgaacaat atccgacagc catcaaacgc
     5641 tatgaaaagc tgtgccaaca gggggacagc agtacgcaga ccttatacta cctgggagtc
     5701 agctattacg cggatgaata ttattacgaa gcgcacgcgt gtttcagcaa actgcaaaaa
     5761 gagatggaag aaaatcccaa tctgctctat tatctgggac gttgctgcgc caagacttcc
     5821 tggaaaaaag aaggcatcga acacctggag aaagctatcg aactgaccat tcccaaagac
     5881 agcaccatga tccgacttta caaaggcttg gtagattgtt gtaaactggc tcaggatact
     5941 ccaaagcaaa tccaggctct cagagaactg tacaaatatg acaagacgaa ccataaactt
     6001 ctttatgaca tcgcctggaa ctattcatat caactcaaag acaacaaatc ggccgaacgt
     6061 tatctgcagg ctttcttaaa aacccgaaag gcgaatgcca ggaaagaaga accggtgagt
     6121 gagaaagggg aacttgtact cggacttgaa aattattaca acgctgccga aaattggctg
     6181 aaagacttac agaaagaaaa gttcttcaaa gaaggaatac cgttagaaag tcagaaacaa
     6241 tagaatctat cccccatgaa acattggata ctcctcctct atctgggctt cagcgtaatg
     6301 ctgcgagccc agaacaccgc ctccgttcaa gaagcaatgg caaactatga ctataaaacg
     6361 gtgatcagac tgattgatga agaaagtgca tcaccacagt tactcataca gaaagccaaa
     6421 gctttaaaag gtttagggcg taccgccgaa gccctgtcca ctttgcaaca tatcattatc
     6481 gagctgcccg aaaatcagca ggcattggta gaggcagcag aatgttgcag gcaattgagc
     6541 aaatttaacg aggccttggg gtattatcgg aaggtgatgg aactcaatcc cgaacatatt
     6601 tacgcacact tgcaatacac ccgcttgtta tacaactatc agcgatacgg cgatgcattg
     6661 cgtgagagta tcgcattggc caggaaagac agttccgcca ccgtattgcg actgatggcg
     6721 gaaagcatgg aaggagctag catgccggta gaaagtatgt tttgctatct ttccatcatc
     6781 aggaaatatc cctccgacta tctctcggta gctaagctgg gcagtatctt caatacaatg
     6841 aaagattaca aaggggcaat tgctttgaca gaggcatacc gccggacgga cagcaccaat
     6901 gtagaagtga accgtcaaaa cgcactggcg tattgtctgc gcaaagaata tcccaccgcc
     6961 atcaaacgtt atcaggatct gaccgcccgg ggagacagca cactgctgac atgttattat
     7021 ctgggagtca gctactacgc tacgaaagaa tactataaag cgcgcgattg gctgctcaaa
     7081 gcaaaatcat gccagtcacc cggcgccaac ctactctact atttgggacg ttcgtgctcc
     7141 aagacattat ggaaacaaga gggaatagga tatctgaacc aggctatcgc cctgactatc
     7201 cccgccgaca gtatcatgga gcgcttatac tcaggcttgg cagactgcta caggcaaacc
     7261 aagcaaaccc gggaccaaat caaggctacc aaagaacaat acaaatatgc ccctgacaag
     7321 catattttac tttataacct ggcgttctta tcggacaaaa ttggagatac taaagccaca
     7381 gagcattact tgcaggcttt tctgcgaaca aaatccaaac aaaatgcagt actacagcag
     7441 ccggatgatg acgaagaaga acccgcaccc tacatagatt actacaaaag tgccaccaat
     7501 aaattggaaa gcatccgaaa agagaaattc ttaaagggag aaaagtgaat tgatcggata
     7561 gatgcatcgt ttcggacaat tcaccactga gtgtagacag agtttcacag aaggagaata
     7621 atggaaaata aatttgaaga tgtgcggtag aaggcacagt ggcacgtagc cgaagtcaca
     7681 tcggcacgca gccgaaatta cggtgctgtg tagctaaagt tacggtgctg cgtagccgaa
     7741 gttacggtgc tgcgtagccg aagttacggt gctgcgtagc cgaagttacg gtgctgcgta
     7801 gccgaagcta tgacggcatc tccttttccg gacgtcacgt tcacctgatt gcatcgaaaa
     7861 gtgctcctta tcggttgagc tccatcccgg agaattctcc aatgaaaacg tttgcataaa
     7921 tagatggcac acagtaagaa agaaaacgga aaacaatccg atgatttacc ctatattagc
     7981 aacattaaat aataacgagc taatatcatg aaaaaattat tgttactctt aggttcattc
     8041 ctactgtcat taaccactta tgcagccatg aacatatcca aaatcgatcc gcccttctgg
     8101 ttcaccggta tgaacaatcc ggaactccag ttaatggtat acggtgaagg catcggccag
     8161 gcatccgtat cagtaaatta tcccggtgta tcgctcagca gcgtcgtgaa actggaaagc
     8221 aacaattacc tgcttgtcta cctacatctc gataaagaag taaagccggg caagatgccc
     8281 atcacattta cggtcggaaa gaagaaattg gtgaaagagt acgaattgaa agcacgcagc
     8341 aaagccggag tcgatcacaa aggttttgac gcatcggatg cattatacct gctgatgccg
     8401 gaccgttttg ccaatggcaa tccggataac gaccggatag aaggcatggc cgaatataaa
     8461 gtggaccgca acgacccgaa cgcacgtcac ggaggcgacc tggccggtat cgaacaaaat
     8521 ctggactatt ttaccgattt gggagtcact gcactctggt tcaccccggt actcgaaaat
     8581 aacatgaaag gcggctcata tcacggatat gcaacaaccg attattacaa ggtagaccca
     8641 cgtttcggca ctaacgagga atatcgctca ctgatagcga aagcccacaa ccggggcatt
     8701 aaggtcgtga tggacatgat cttcaatcat tgcggagtag aacatccctg gatcaaggac
     8761 atgccttcaa aggactggtt caaccatgcg gacttcaaga acaactttgt gcaaacttcc
     8821 tacaagctga ctccacatgt agatccgtat gcctcggagt acgatttcga ccagatgaac
     8881 aacggctggt tcgtggaagc catgcctgac ctcaaccaaa agaaccctca cgtatacaaa
     8941 tacctcttgc agaacagcct gtggtggatt gagtacgccg atatcgacgg catccggatg
     9001 gacacctacc cgtatgccga ttacgatgcc atgagcaact ggatgaaaga actgaacgaa
     9061 gaatacccca actacaacac ggtgggcgaa acctgggtta ccgaaccggc ctatacagcc
     9121 tggtggcaga aagactccaa gctctccgcc ccgcgcaaca gtcacttgaa aacagtcatg
     9181 gatttcagct tcttcgacaa agtcaacacg gctaagaatg aacaaacgga cacttggttc
     9241 aaaggattgg accgtgtcta caacaatttt gtatacgatt atctgtatcc caatccggct
     9301 tccgtactgg ctttcatcga gaatcatgac accgaccgtt tcctgggtga aggcgaaaac
     9361 ctcgatatgc tgaaacaggc ctccaccctt ttattgacca cccgacgcat cccgcaactc
     9421 tattatggaa cggaggtgat gatgaacgga gtaaagagta aaagcgacgg ctatgtacga
     9481 aaggacttcc caggcggatg ggcggacgat aaagagaatg ccctgactcc cgagggacgt
     9541 acccgattgc agaatgaaag ctataacttc taccgcaacc tgctgaactg gcgtaagggc
     9601 aacgatgtga tcgccaaagg cagcatgaaa cagttcatgg tgcagcacgg cgtatatgct
     9661 tatgcacgcc aatataaagg gaaaacggta ttcgtcctgt tgaacggtac ggataaagag
     9721 gtgaaacttc ccctgaaata ctatgccgaa gtgctgaaag acaagactca aggaaaagac
     9781 gtcattagcg gaaaagtaac gacactcaat gaagaactga caatggcacc ccgccaatca
     9841 atggttatag agctttaatc ttacaccggt tataaccgca taagcaaagg gcacaaagga
     9901 tttcacccga catcctctgt gccctttgtg tagcctaatg cgaataataa tagtcaaacg
     9961 tttgactatt atcgaagaat attcctacct ttgcaccgac taaaagaata cgacgatgac
    10021 aaacaacgaa tcggagcgcg agctcgtcct acaaacctta cgaacctgga tggcattccg
    10081 ccaggccgtt cagcgggtgc tcaaacgcca caacgtggat atgaccttcg agatgctgca
    10141 agtaatgaac tgcctgtgga acaaacaagg catcagccag caatccctgg ctgagaaaac
    10201 agcaaaggac aaggcttgcc tgaccaatct gattaataat ctggaaaaga aaaactgggt
    10261 gatacggaag gaaggcccct ccgaccgccg aaaccgcctg attttcctga ccccccaagg
    10321 cgaagaactt gccctcaccg tgaaacccct gatcaacgat atctatgccc aaaccggaac
    10381 agagatggag gcaagccgga taacggaatg catcgaagac ctgaagagac tgcatgaagt
    10441 gctcaatgag atctaaaaga aatccgccat gtccacccgt cagataaagc taaaacaatt
    10501 gagaagactg aagttcagga acatctttct caacacagta tgcatcctgc tggcattggc
    10561 aggtatttca tggacagtaa actacttctg gaaatacgcc cgctacgaga taaccaatga
    10621 tgccgtagtg gatcaataca tcgctccgct aaacatccgg ataccgggct atatcaaaga
    10681 agtacgtttt accgaacacc agtatgttca tgccagcgac acgttactga tactggacga
    10741 ccgggaatac cggatccggc tgaaagacgc ggaagcggcc ttgatggatg ccttgggatc
    10801 aaaggaagtg ttaaactccg gcatccggac ttcaggagta aatgtagccg tgcaggaagc
    10861 caacatagcc gaaacactgg cacgcctttc acagcaagaa gcggaactga accgatatac
    10921 ccggctcttg aaaaagcagg ccgtcagcca acaggattat gaactggcca aagcgaactt
    10981 cgaagcgacc cgggcaagat acaacgccct gttgcgacaa aaagaagcgg cccaatcgca
    11041 gtattccgaa accagcaaac gcagtacagg cgccgaagcc aatatcctcc ggaaggaggc
    11101 cgacctggag atggcccgac taaacctgtc gtataccgtt gtcaccgcac cctatgacgg
    11161 atacacggga cgacgtacac ttgaaccggg acagttcgta caaggcggac aaactctttc
    11221 ctacctggta cggggcaatg acaagtgggt gacagccaat tataaagaaa ctcaaatagc
    11281 ccatatctat atcgggcaaa aagtccgcat caaagtagat gctttcagcg gacgcacttt
    11341 tcacgggacc gtaaccgcca tttccgaagc caccggatcg aaatactctc tggtaccgac
    11401 cgacaattcg gcaggaaact tcgtcaaagt gcagcaacgc attccggtcc gcatcgatct
    11461 caatgacgcc tcacccgaag agatggaatg cctccgtgca gggatgatgg tagaaacgga
    11521 ggcggtccgc ccttaggctt atggtgaagc tcaatctgcc tacccgtccc tgggtgcctc
    11581 aatggttggg catcgtgacc atgtttattg tcatctttcc catcaccctg ctcaacggtg
    11641 cctacacagg aagtatggtc gaagtatcga acacgctggg agtattgagc gaagatatta
    11701 ccatggctta ctattcagct tcggtaggga tggctgttgc ctatcccatc gtaccgaaaa
    11761 tacgcaccat agccactccg aaaaccttac tgcttaccga tctgctgcta cagatattct
    11821 tcagcctggt atgcgccaaa accggtagta tggacgtcat catggtatgc agtttctgta
    11881 tgggatttct caaagccttc gtcatgttgg agttcatcat cctgatccgc ccgctcttca
    11941 gtccgaaaaa cgtacgaagt gaattctatg cctacttcta ccccatcgtt ttctccggag
    12001 gccagctatc gatggctatc accgctcaac tggcctatca ctaccaatgg cagcacatgt
    12061 actattttgt caccatcctc ttgctgatcg ccattctgtt cgtcatctgt ttcttccgct
    12121 atgcaaggcg tcccatgcac attccgttca aagagatgga cggaagaagc atgttcatca
    12181 tcgccaccgc tttcctgcta acgctctata catttaccta cgggaaaaca ctcgattggt
    12241 tcgcatcccc gaagatcaga gtatatgtat tcgtcatccc gctcctgata gctcttttca
    12301 tccatcggca gcgtacacaa ggcaaaccct ttgtcagcct gaaaccactc tttctgcata
    12361 aatccatcat cggatatggc ttcatggtac tcaccatgtt cctgacagcc accagttcac
    12421 tggtaaccaa ctatatgaac agcatcatcc gggtagacag catacacgcc aattcgctga
    12481 gcctgtggct attgcccgga tatgtggtag gggccgtcat ttgcttctgg tggttccgat
    12541 ggcaacgatg gcggtttcgc ttcctcattt caggaggtat gttctgctac gtcatctatc
    12601 tggctatcct ctactttggt atcacccctt atggaaccta tgaaatgctc tacctcccca
    12661 tcctgttccg gggagtgggg atgatggtca tattcattgc gttcggtgtg tttgttgtcg
    12721 aagatttaga cccgcgcctg acgttgtcca atgccttctt cctgatttca ttccgctcag
    12781 tattggctcc ggtcctgtcc gcttcattct ttaacaacat gctttactat ctgcaggcaa
    12841 aggggatgaa cattctttcg gaaaacatga cgctgaccaa tccgctggcc gaacaaaaat
    12901 acaatcaggc attgagcaat gccctggcgc aagggcacga attcggcgag gccggacaat
    12961 tggcagccaa cagcctgtac tccactttgc agcagcaatc cctgctgctt gccctgaaaa
    13021 ccctgatcgg ctatgtactg atactggcac tggtgattgc tgtcatcgca gcgttcattc
    13081 ctttccataa aacactgaag gtggctgtag tgaagacggg tgacgatatg gtataatggg
    13141 aagggataca aaaaagccac tcaattgctt gagtggcttc ttaaaatata aattaaatca
    13201 agtaaaactt ttaaatacta gatttggaat ttattcagct aacttgttgt cagaacccag
    13261 cacgttgata attttgtgct tgtagagttt ttccatattg tcgcgagccg gtcccagata
    13321 tttacgcggg tcgaactcag ccggtttttc tgcgaatacc ttacggatag cagcagtcat
    13381 agccaggcga gagtctgagt cgatgttgat cttgcaaaca gcagacttag cggctttacg
    13441 cagttcctct tcaggaatac cgatagcagc tttcagtgca ccaccaaact ggttgatagt
    13501 tgcaacctct tcttcaggaa ctgaagatga tccgtgaaga acgataggga atcccggaag
    13561 ttctttcatt acaccgtcca atacgtcgaa tgccaacgga ggaggaacca tacggcctgt
    13621 cttcggatcg atgtggcact gttccggagt aaatttgtaa gcaccgtgag aagtaccgat
    13681 agagatagcc aatgaatcgc aacctgtctt ggtaacgaaa tcaactactt cgtccggttc
    13741 agtatatgtg tggtggtcag aagaaacttc gtcttctaca cctgccaata cgccaagttc
    13801 accttctaca gttacatcga actggtgagc gtattcaaca actttcttag tcagagcaac
    13861 gttttcgtcg taaggaaggt gagaaccgtc gatcattaca gaagagaagc ctgagtcgat
    13921 acagcttttg caagtttcga aagtatctcc gtggtcgagg tgcaaaacga tttcaggatt
    13981 tttgcagccg agttcttttg catattctac agcaccctga gccatgtaac gcagcaatgt
    14041 agcgttagca tactgacgag caccttttga tacctgcaaa ataaccggag acttagtttc
    14101 tacagcagcc ttgatgatag cctgcatctg ttccatattg ttgaagttga atgcagggat
    14161 tgcatatcca cccttgatag ccttagcaaa catatctcta gtgtttacca gacctaaatc
    14221 tttgtaatta accattttgt ttaaaagttt attgttagtg aattaaaaat tctatgcaaa
    14281 agtaagaata atcctttgaa tagagaaacc ctcgggcgga aatatccgtt tgaggagcgt
    14341 aattcaattc tatttcaaat tatttcccat cctttaagag ctgtttgtaa tgtctacgta
    14401 gcaaataaag gttttttatt gtttcctcat atatataatg gtaggcaaat gatcgctgta
    14461 accatccaac cacactctgc caccatatgt acgcaggggt gcacccttat atttaccatc
    14521 ctgctgaaac aggtaatcgc gcatgaaaac ttcattgtga tcatatttca atccttttgt
    14581 tgcttgaagc agagtgggtg aaaggatgat ctgatcgaac agattccatt tgccgcgata
    14641 gagcaaagtg cccactccct tatcttccag cgtcacccac caggggttgt aaaggtcatc
    14701 ttcagtcata tcttcgacgt gtttctttgc ccccagtacg gcaaggctca agtccatcgg
    14761 atc
//
