LOCUS       gnlProkkaKOAMHLGD_226   4720 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|KOAMHLGD_226.
ACCESSION   gnlProkkaKOAMHLGD_226
VERSION     gnlProkkaKOAMHLGD_226
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 23:03:04
            Original ID  :: gnl|Prokka|KOAMHLGD_226
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 4720
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..402
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     125.9; E-value: 3e-38)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg226_1"
                     /transl_table=11
                     /translation="MISLNGFFYVTQHLLKNMLVKRYGRIVNIVSLSGIQGMPGQANYS
                     AAKGGVIAATKALAQEVAKKKVTVNAVAPGFIRTDMTEGIDENEWKKHIPAGRFGTAEE
                     VADLVGFLASPASSYITGEVISINGGLYT"
     protocluster    1..4720
                     /aStool="rule-based-clusters"
                     /category="PKS"
                     /contig_edge="True"
                     /core_location="[428:1652]"
                     /cutoff="20000"
                     /detection_rule="(APE_KS1 or APE_KS2)"
                     /neighbourhood="20000"
                     /product="arylpolyene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      429..1652
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(APE_KS1 or APE_KS2)"
                     /neighbourhood="20000"
                     /product="arylpolyene"
                     /protocluster_number="1"
     cand_cluster    1..4720
                     /SMILES=""
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(APE_KS1 or APE_KS2)"
                     /kind="single"
                     /product="arylpolyene"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..4720
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="arylpolyene"
                     /region_number="1"
                     /rules="(APE_KS1 or APE_KS2)"
                     /tool="antismash"
     CDS             429..1652
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (65-405). E-value:
                     7.5e-54. Score: 175.0. Matches aSDomain:
                     nrpspksdomains_ctg226_2_PKS_KS.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     arylpolyene: APE_KS1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022:Beta-ketoacyl synthase (Score: 297.8; E-value:
                     2.2e-90)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg226_2"
                     /sec_met_domain="APE_KS1 (E-value: 5.2e-161, bitscore:
                     524.7, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRVVITGMGIYSCIGKNLDEVKDSLYNGKSGIGIDPVRKELGYF
                     SALTGILERPDLKKLLDRRKRLCLPEQGEYAYLATLEAFRNAGIDDAFLEANEVGILYG
                     NDSSAAPVINAVDIIREKKNTALVGSGSIFQSMNSTVTMNLSVIFKLRGVNFTIAGACA
                     SGSHAIGMGYLLIKSGLQDCILCGGAQEVNPYAVGSFDGLSAFSTQEAEPEKASKPFDK
                     RRDGLIPSGGAASLVLESYESAVKRGAPILAEVIGYGFSSNGDHISVPNVDGPKRSLQM
                     AIKDAGIALEQISYINAHATSTPVGDLNEAKAIAEVFEGHHPYVTSTKSMTGHEMWMAG
                     ASEVIYSILMMNNGFIAPNLNFEEPDEASAQLNIPTQRVNLEFDTFLSNSFGFGGTNST
                     LIIRQIKE"
     aSDomain        624..1643
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg226_2_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="7.50E-54"
                     /label="ctg226_2_PKS_KS.1"
                     /locus_tag="ctg226_2"
                     /protein_end="405"
                     /protein_start="65"
                     /score="175.0"
                     /tool="antismash"
                     /translation="RLCLPEQGEYAYLATLEAFRNAGIDDAFLEANEVGILYGNDSSAA
                     PVINAVDIIREKKNTALVGSGSIFQSMNSTVTMNLSVIFKLRGVNFTIAGACASGSHAI
                     GMGYLLIKSGLQDCILCGGAQEVNPYAVGSFDGLSAFSTQEAEPEKASKPFDKRRDGLI
                     PSGGAASLVLESYESAVKRGAPILAEVIGYGFSSNGDHISVPNVDGPKRSLQMAIKDAG
                     IALEQISYINAHATSTPVGDLNEAKAIAEVFEGHHPYVTSTKSMTGHEMWMAGASEVIY
                     SILMMNNGFIAPNLNFEEPDEASAQLNIPTQRVNLEFDTFLSNSFGFGGTNSTLIIRQI
                     "
     CDS             1674..1925
                     /NRPS_PKS="Domain: PP-binding (7-75). E-value: 3.8e-14.
                     Score: 44.9. Matches aSDomain:
                     nrpspksdomains_ctg226_3_PP-binding.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg226_3"
                     /sec_met_domain="PP-binding (E-value: 4.7e-15, bitscore:
                     44.9, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTNEEIIEKIRTTLAEEFEVDIDVIQPDAPLMETLELDSLDLVDM
                     VVLVEKNFGFNVTGQDFAGIKTFQDFYDLVITRMQEAK"
     aSDomain        1695..1898
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg226_3_PP-binding.1"
                     /evalue="3.80E-14"
                     /label="ctg226_3_PP-binding.1"
                     /locus_tag="ctg226_3"
                     /protein_end="75"
                     /protein_start="7"
                     /score="44.9"
                     /tool="antismash"
                     /translation="EKIRTTLAEEFEVDIDVIQPDAPLMETLELDSLDLVDMVVLVEKN
                     FGFNVTGQDFAGIKTFQDFYDLV"
     CDS             1928..2863
                     /locus_tag="ctg226_4"
                     /transl_table=11
                     /translation="MSTWKGKTRGGTFGYLFFIYLIKYLGITAAYLFLSLVVLYFIPFA
                     PKATKSTWFYARHILKYNRIRSLKMLLLNYYRLGQILIDKVAIGNGKVNQYQFKFERYP
                     EFLQLLNSEQGVIMIGAHVGNWEIGVPFFDDYGKKINIVMYDAEHRRIKEILEKNGQDK
                     EFKIIPVNEDNLTHVFRITEAINQKEYVCFQGDRYLNKEKLLPGILLGQKAPFPAGPFL
                     LASRMKVPVVFYFAMREPGRTYRFHFIIAEPVVRTKEKKAEMALLEQYTVALEQILKRY
                     PEQWFNYYPFWEPAGKQSPDLKEKQKDATE"
     CDS             2850..3920
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1042:O-methyltransferase (Score: 125.2; E-value:
                     5.6e-38)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg226_5"
                     /transl_table=11
                     /translation="MQQNKYDKEPLTAVEAQRLAQEIAFGPIVFQVSRLMLKFGIFQLL
                     ADERKGMTQEEISKACGLPSYGAQVLLEASLTIGTVLLREGRYCLAKAGWFLLNDKMVR
                     VNMDFNHDVNYQGMFHLEEAITNGRPEGLKVFGEWSTIYEGLSSLPSQVQKSWFGFDHY
                     YSDCSFDEALAIVFARHPKTLLDVGGNTGRWATKCVSYDDTVEVTIMDLPQQLEMMRQQ
                     TKELPGATRIHGHGANLLDPEVPFPTRFDAIWMSQFLDCFSEEEVTSILTRAARSMTRE
                     SRLYIMETFWNRQKFDTAAYCLTQISLYFTAMANGNSKMYHSDDMQRCIEAAGLEIEEI
                     HDHLGMGHSIVQCRLK"
     CDS             3917..4351
                     /locus_tag="ctg226_6"
                     /transl_table=11
                     /translation="MNREAVIQGEGILNLIPQRPPIVMVDSFFGFEENRSYSGLTVTTD
                     NLFCEAGRLQEPGIIEHIAQSAAARIGFIYTRQGEKVPLGFIGSVDKLKIYNLPEAGMK
                     LFTEITVVQEVFDITLISAQVKTEEELIAECKMKIFIKKE"
     CDS             4348..4719
                     /locus_tag="ctg226_7"
                     /transl_table=11
                     /translation="MKRKTNQQIAALTNRTTFRVRFSEIDSMQIVWHGEYVRYFEDGRE
                     AFGKQYGLDYMSIYREGYMVPIVDLTCQFKQSLSFGEEAIIETRYIACEAAKIKFEYVI
                     YRATDQSVVATGSTIQVFLN"
ORIGIN
        1 gatatcagtc tgaacggatt cttttatgtg acacagcatt tattgaagaa tatgctggtc
       61 aaacgttatg gacgcattgt caatatcgta tccttgtcag gtattcaggg aatgcccgga
      121 caagccaatt attccgcagc caaaggtggc gtaatagctg ctaccaaagc actggcacaa
      181 gaagtggcca agaaaaaggt aacagtcaac gcagtagctc cgggatttat ccgcacggat
      241 atgacggaag ggattgatga gaacgaatgg aaaaaacaca ttcctgcagg acgtttcggt
      301 actgcggaag aggttgccga tctggttggt tttctggcat ctccggcctc atcctatatc
      361 acaggggagg tgatttccat caacggagga ctatatactt aaaacaaaag catagaatag
      421 acaaaataat gaaaagagtt gttatcacgg gaatggggat ttactcttgc atcggcaaga
      481 acctggatga agtaaaagac tcactataca atgggaaatc ggggattggc atagatccgg
      541 tacggaaaga actgggctat ttttctgcat taacgggcat attggaacgt cccgacttga
      601 agaaactatt agatcgtcgt aaacgtctct gcctgccgga acagggagag tatgcttatc
      661 tcgctacttt ggaggctttc cgcaacgccg gtattgacga tgcttttctc gaagctaatg
      721 aagtgggtat cttgtatggc aatgatagta gtgccgcccc tgttatcaac gcagtggaca
      781 tcattcgtga aaagaaaaac acagcgttgg taggttccgg ttctattttc cagtcgatga
      841 attctaccgt gacaatgaac ctgtcggtta tcttcaagct tagaggagtt aacttcacca
      901 ttgccggagc ctgcgcaagt ggttcccatg ctattggcat ggggtatctg ctcattaaat
      961 caggattgca ggattgtatt ctttgcggtg gcgcacaaga agtaaatcct tatgcggtcg
     1021 gcagtttcga cgggctaagc gcattttcca cccaggaagc agagcccgag aaagcctcca
     1081 aaccttttga taaacgacgt gacggactga ttccgagtgg aggagccgcc agtctggtat
     1141 tagagagcta tgaatcggca gtaaaaaggg gagctcccat tttggccgaa gttatcggtt
     1201 acggtttctc ttccaatgga gatcatatct ccgtaccgaa tgtggacggt ccgaaacgtt
     1261 ctcttcagat ggccatcaaa gatgcgggta ttgcactcga gcaaatcagt tatatcaacg
     1321 cacacgccac ttccactccg gtaggcgacc tgaacgaagc gaaagccatt gcggaagtat
     1381 ttgaaggaca tcacccgtat gtcacttcca cgaagtctat gaccggacat gaaatgtgga
     1441 tggcaggtgc cagtgaagtg atttactcca tcctcatgat gaataacggt ttcatcgctc
     1501 ccaacctcaa tttcgaggaa ccggacgagg cttccgcaca gttgaatata cctacccaac
     1561 gggtaaatct ggaatttgat acgttccttt ccaactcgtt tggattcgga ggaaccaatt
     1621 ccaccctgat tatacgccaa atcaaagaat aaattactaa agaaaacaga tatatgacaa
     1681 acgaagaaat catcgagaaa ataagaacaa ctctggcaga agagtttgaa gtagacatcg
     1741 acgtcatcca gccggatgcg ccgttaatgg aaactcttga actggacagt ctggacttgg
     1801 tcgacatggt ggtactggta gaaaagaatt tcggtttcaa tgtaaccgga caagactttg
     1861 caggtatcaa aaccttccag gacttctacg atctcgttat cacccgtatg caggaagcca
     1921 agtaaatatg tcgacgtgga aaggcaaaac ccggggagga acgttcggat acttattctt
     1981 tatttacctg attaagtatc tgggcatcac tgccgcttat ctttttctaa gcctggtagt
     2041 gctctacttc ataccgtttg ctccgaaagc aaccaaaagc acctggtttt atgcccgcca
     2101 cattctgaaa tacaatagga tacgttcttt gaaaatgtta ctactcaact attaccgatt
     2161 aggacaaatc ctgattgaca aggtagccat cggtaatgga aaagtaaatc aatatcagtt
     2221 caaattcgag cggtatccgg agtttctgca actgctgaac agtgaacagg gagtgattat
     2281 gattggcgcc catgtgggaa actgggaaat aggcgttcct ttctttgatg attacggaaa
     2341 gaaaatcaat atcgtgatgt acgatgccga acatcgtaga atcaaagaga tcctggagaa
     2401 aaacggtcag gacaaggagt ttaagattat ccctgtcaat gaagacaacc tgacacacgt
     2461 tttccgcata accgaggcga tcaaccaaaa agaatatgta tgtttccagg gcgaccgtta
     2521 tctgaacaaa gagaaacttc tgccaggaat tttactggga cagaaagctc ctttccctgc
     2581 cggtcctttc ctgctggctt cgcgaatgaa agttccggtg gtattctact ttgctatgag
     2641 ggaaccggga agaacttacc gttttcattt tataatagcg gaaccggtag tacgaacaaa
     2701 agaaaagaaa gcggagatgg ctctgctcga acaatatact gttgctttgg aacagatact
     2761 aaaacgctat ccggaacaat ggttcaatta ttatccattc tgggaacctg ccggaaagca
     2821 gtcaccggat ttaaaagaga aacaaaaaga tgcaacagaa taaatatgac aaagagccgt
     2881 tgacagcggt agaggcacaa cgcctggcac aagaaatagc ttttgggcct attgtttttc
     2941 aggtatcacg ccttatgctt aaattcggaa ttttccagtt attggccgac gagcgcaaag
     3001 gtatgacgca agaagaaatc agcaaagctt gtgggctgcc ctcttatggc gcacaagtat
     3061 tgttggaggc atcattgact atcggcaccg tattgttgcg tgaagggcga tactgccttg
     3121 cgaaagccgg ctggtttctg ctcaatgaca aaatggtacg tgtcaatatg gacttcaacc
     3181 atgatgtcaa ctatcaggga atgtttcatc tggaagaagc catcaccaac ggacgtcctg
     3241 aaggactgaa agtattcggt gaatggagta ctatctatga agggttgtca agtctgcctt
     3301 cacaagtaca aaagagctgg ttcggtttcg atcattatta ctcggattgt tcgttcgatg
     3361 aagcactggc aattgtcttc gcccgccatc ccaagacttt attggatgtg ggaggcaata
     3421 ccggccgctg ggcgaccaaa tgcgtaagct acgacgacac agtggaagta accatcatgg
     3481 atcttccgca acaattggag atgatgcgtc aacaaaccaa agagctgccc ggagctacac
     3541 gtatccacgg tcatggtgcc aatctgcttg atccggaggt gcctttcccg acaaggttcg
     3601 atgctatttg gatgagccag ttcctcgatt gtttctcgga agaagaagtt accagcatat
     3661 tgacccgtgc agcccgttct atgacccgag agagccgcct gtatattatg gagactttct
     3721 ggaaccgaca gaaatttgac acagccgctt attgcctgac acaaatcagt ctctatttta
     3781 cagcgatggc aaacggaaac agcaagatgt atcattcgga cgatatgcaa cgatgcatcg
     3841 aagcagcagg attggaaatc gaagagatac atgaccattt aggaatggga cacagcatcg
     3901 tacaatgcag attgaaatga acagagaagc cgtcatacaa ggagaaggaa tactcaacct
     3961 gattccacag cgtccgccaa tcgttatggt ggacagtttc ttcggatttg aagaaaaccg
     4021 ttcatattcc ggactgactg tcactaccga caatttattt tgtgaggcag gcagactgca
     4081 agagccggga attattgagc atatcgcaca atcagcggct gcacgtatcg ggtttattta
     4141 tacccggcag ggtgaaaaag ttccgttagg ttttatcggt tcggtagaca aacttaaaat
     4201 ctacaatttg ccggaagccg gaatgaaatt atttacagag attaccgtcg tacaagaggt
     4261 attcgatatt acgcttattt cggcacaagt gaaaacggaa gaagagctga ttgctgaatg
     4321 taagatgaaa atatttatca aaaaagaatg aaacggaaaa caaatcaaca gattgcagct
     4381 ttgactaacc ggactacttt cagagtacgg ttcagcgaaa ttgactccat gcagattgta
     4441 tggcatggcg agtacgtgcg ctactttgaa gatgggcggg aagctttcgg caaacagtat
     4501 ggtttggatt atatgagcat ttaccgggaa ggctacatgg ttcccatcgt agatttaacc
     4561 tgccagttca agcaatcatt gtcctttggt gaagaagcga ttatcgaaac acgctatatt
     4621 gcctgtgagg cagccaagat aaaattcgaa tacgttatct accgggctac cgaccagagt
     4681 gtagtggcca ccggaagcac catacaagtg ttcctgaacc
//
