LOCUS       c00136_gnlPro..        11925 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|ODKKLADI_136.
ACCESSION   c00136_gnlPro..
VERSION     c00136_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-05 00:41:26
            Original ID  :: gnl|Prokka|ODKKLADI_136
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 11925
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..11925
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[160:6253]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      161..6253
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..11925
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..11925
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             161..1960
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ILVD_EDD"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg136_1"
                     /sec_met_domain="ILVD_EDD (E-value: 4.9e-217, bitscore:
                     710.6, seeds: 918, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKQLRSSFSTQGRRMAGARALWAANGMKKNQMGKPIIAIVNSFT
                     QFVPGHVHLHEIGQLVKAEIEKLGCFAAEFNTIAIDDGIAMGHDGMLYSLPSRDIIADS
                     VEYMVNAHKADAMVCISNCDKITPGMLMAAMRLNIPAVFVSGGPMEAGEWNGQHLDLID
                     AMIKSADESVSDQEVANIEQNACPTCGCCSGMFTANSMNCLNEAIGLALPGNGTIVATH
                     ENRTQLFKDAAELIVKNAKLYYEEGDESVLPRSIATRQAFLNAMTLDIAMGGSTNTVLH
                     LLAVAHEAEVDFKMDDIDMLSRKAPCLCKVAPNTQKYHIQDVNRAGGIIAIMDELAKGG
                     LIDTSVRRVDGMSLAEAINEYSITSPNVSEKAIKKYSSAAGNKFNLVLGSQGMYYKELD
                     KDRANGCIRDLEHAYSKDGGLAVLKGNIAQDGCVVKTAGVDESIWKFTGPAKVFDSQEA
                     ACEGILGGRVVSGDVVVITHEGPKGGPGMQEMLYPTSYIKSRHLGKECALITDGRFSGG
                     TSGLSIGHISPEAAAGGNIGKIVDGDIIEIDIPARKINVRLTDEELAARPMTPVTRDRY
                     VPKSLKAYASMVSSADKGAVRII"
     CDS             2085..3779
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg136_2"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1e-47, bitscore:
                     150.8, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKDLITGAEALMRSLEHQGVTTIFGYPGGSIMPVFDALYDHQNIL
                     NHILVRHEQGAAHAAQGYARVSGDVGVCLVTSGPGATNTVTGIADAMIDSTPIVVIAGQ
                     VGTGFLGTDAFQEVDLVGITQPITKWSYQIRRAEDVAWAVARAFYIARSGRPGPVVLDF
                     AKNAQVEKTKYEPTKVDFIRSYVPVPDTDEESVQAAAELINNAERPLVLVGQGVELGNA
                     QSELREFIEKADMPAGCTLLGLSALPTEHPLNKGMLGMHGNLGPNINTNKCDVLIAVGM
                     RFDDRVTGNLATYAKQAKVIHFDIDPAEVNKNVKVDVAVLGDCKETLASVTKLLKKNTH
                     TEWIDSFKEYEKVEEEKVIRPELHPATNSLSMGEVVRAVSNATQHEAVLVTDVGQNQMI
                     SARYFKYTKERSIITSGGLGTMGFGLPAAIGATFGAPERTVCVFMGDGGLQMNIQELGT
                     IMEQKAPVKIICLNNNYLGNVRQWQAMFFNRRYSFTPMLNPDYMKVASAYDIPSKRAFT
                     REELKEAIAEMLATDGPFLLEACVVEEGNVLPMTPPGGSVNQMLLEC"
     CDS             3836..4393
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg136_3"
                     /sec_met_domain="ALS_ss_C (E-value: 2.4e-19, bitscore:
                     58.6, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDKTLYTIIVHSENIAGLLNQVTAVFTRRQINIESLNVSASSIK
                     GVHKYTITALTDKDTIEKVVKQIEKKIDVIQAHYFTEDEIYFHEIALYKVSTPAFQETP
                     EASKLIRRYNARIVEVNPVFSIVEKNGMSEDITSLYGELKALNCVLQFVRSGRVAITTS
                     CFERVNEFLDGREAMYNQSKNQ"
     CDS             4399..5142
                     /locus_tag="ctg136_4"
                     /transl_table=11
                     /translation="MSEENRIGTYQFVAEPFHVDFNGRLTMGVLGNHLLNCAGFHANDR
                     GFGIATLNEDNYTWVLSRLAIELDEMPYQYENFSVQTWVENVYRLFTDRNFAILDKDGK
                     KIGYARSVWAMINLNTRKPADLLTLHGGSIVDYVCDEPCPIEKPSRIKVTSDQPIATLT
                     AKYSDIDINGHVNSIRYIEHILDLFPIELYKTKRIRRFEMAYVAESYFGDELSFFCDEV
                     NASEFHVEVKKNGSEVVCRSKVIFE"
     CDS             5210..6253
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: IlvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg136_5"
                     /sec_met_domain="IlvN (E-value: 1e-46, bitscore: 147.7,
                     seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="IlvC (E-value: 5.3e-42, bitscore: 132.7,
                     seeds: 295, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAQLNFGGTTETVVIRDEFPLEKAREVLENETIAVIGYGVQGPGQ
                     ALNLRDNGFNVIVGQREGKTYDKAVADGWVPGETLFGIEEACEKGTIVMCLLSDAAVMS
                     VWPTIKPYLTAGKALYFSHGFAITWNDRTGVVPPADIDVIMVAPKGSGTSLRTMFLEGR
                     GLNSSYAIYQDATGKAYERTIALGIGIGSGYLFETTFQREATSDLTGERGSLMGAIQGL
                     LLAQYEVLRENGHSPSEAFNETVEELTQSLMPLFAKNGMDWMYANCSTTAQRGALDWMG
                     PFHDAIKPVVEKLYNSVKTGNEAQISIDSNSQPDYREKLNEELRQLRESEMWQTAVTVR
                     KLRPENN"
     CDS             6444..8405
                     /locus_tag="ctg136_6"
                     /transl_table=11
                     /translation="MMCFNLPQRMINIAKLACVIGVVSVVFSSCLQKDVYDPANSGDKE
                     EVTLDNYFDFATTKNIQLNIDYGKECPRAYFEVYAENPLSYVAEGGQIIKKAGVSHIAT
                     GFTDIQGRYIKPASFPTAVSEVYIYSPDFGVPTLYKTKVVGSDVSAKITFENALDVTAL
                     DSSTRSAQTRSSLKFITNVIPNVLGTWNVNTGRPNYLDASKKINVDATLKSYITTYFPE
                     GKNNKGTLVSDDADILITKDANVVINYFGGNTAAQSVFAYYCYPKDASVDEMREATKHA
                     CVIFPNAHGNSLGYYSGVAVNLKYISKDGKFPQDDPERIPADTRIGFLIWNNGWVNAKA
                     NGNMFYSTKALNSDGISHTAIFAAENKAGERVNVITMEDWKNGENDYNDVAFVISSNPI
                     AAIEVPDVPNPGDRQGTEKYSGVLGFEDNWPEQGDYDLNDVVMKYQSSVDYNIDNKVLN
                     IIDKFTLAWTGANYKNSFAYEVPFDLSKASQVIINGDEITSYSGNVITLFKDAKAELGV
                     SNVNAEDMINQNIQEKTYTVSIQFNNPTLDKSVVVAPYNPFIKVFNSATEVHLTDHKPT
                     TGANNRFPSGADISRGDVDGTYFICKDGFPFAIHVDARLDASILNLDLKKENQRIDKTY
                     PKFAEWAKTRDPQIKWWK"
     CDS             complement(8549..10486)
                     /locus_tag="ctg136_7"
                     /transl_table=11
                     /translation="MKYFFYPERRFVTFAPIMSNNPKSPIIDLQQQQLLLRMEYEYEKE
                     EFKRQTETMGVARKVKRGLCWYPVSLGRSYYNSLNQLVIDITRTENKEIEHSFEFGRPV
                     CFFHQSFEGKVKYMDFIATISFADEERMVVVLPGAGALAELQTDGILGVQLYFDETSYR
                     AMFEALEDTIRAKDNRLAELRDILLGTQKPGFRELYPVRFPWLNSTQETAVNKVLCTRD
                     VSIVHGPPGTGKTTTLVEAIYETLHREPQVLVCAQSNTAVDWICEKLVDRGVPVLRIGN
                     PTRVNDKMLSSTYERRFESHPAYPELWGIRKSIREMGSRMRRGSYSEREGMRNRMSRLR
                     DRATELEIQINADLFDSARVIASTLVSSNHRLLNGRRFSTLFIDEAAQALEAACWIAIR
                     KADRVILAGDHCQLPPTIKCIEASRGGLDHTLMEKVVQQKPSAVSLLKVQYRMHETIMQ
                     FPSDWFYHGELEAAPEVRYRGILDFDTPMNWIDTSEMDFHEDFVGESFGRINKQEANLL
                     LQELETYIERIGKERILDERIDFGLISPYKAQVQYLRGKIKGSSFLRPFRSLITVNTVD
                     GFQGQERDVIFISLVRANEDGQIGFLNDLRRMNVAITRARMKLVILGDTSTLAKHPFYK
                     RLMLFIKKED"
     CDS             10553..11923
                     /locus_tag="ctg136_8"
                     /transl_table=11
                     /translation="MVYDVTMLEAFYAAYKGKVEHVRAILKRPLTLAEKILYAHLYDVA
                     DLKDYKRGEDYVNFRPDRVAMQDATAQMALLQFMNAGKDQVAVPSTVHCDHLIQAYKGA
                     KADIATARLTNEEVYDFLRDVSSRYGIGFWKPGAGIIHQVVLENYAFPGGMMVGTDSHT
                     PNAGGLGMVAIGVGGADAVDVMTGMEWELKMPKIIGVRLTGKLSGWTSPKDVILKLAGI
                     LTVKGGTNAIIEYFGPGTESLSATGKATICNMGAEVGATTSLFPFDGRMATYLRATGRD
                     CVVDWAESVGADLRADDIVTDEPSNYYDRVIEIDLSELEPYINGPFTPDAATPISEFAE
                     KVLLNGYPRKMEVGLIGSCTNSSYQDLSRAASLAKQVTEKNLSVASPLIVNPGSEQIRA
                     TAERDGMIEAFERLGATIMANACGPCIGQWKRQTDDPTRKNSIVTSFNRNFAKRADGN"
ORIGIN
        1 tctattaacc tagcagtcct gcatattatt cgcgtcgtgg tggtcccatc aagagcgtga
       61 gaaaggtttt tgtgttgtat gtgttcgtac cataaaagat agaatttaga gcctttctca
      121 cttgtgtgag gaaggctctt taattaaaag atagattgaa atgaaaaagc aattacgcag
      181 ttcgtttagt acacaaggcc gtcggatggc gggagcccgt gcattgtggg cagccaacgg
      241 catgaagaag aatcaaatgg gtaaacccat tatcgctatc gtcaattcgt tcacacagtt
      301 tgtcccgggg catgtacacc tacatgaaat cggtcagctg gtgaaggcag agattgagaa
      361 gctgggatgc ttcgctgcgg aattcaatac aatagctatc gacgatggta tagcaatggg
      421 acatgacggt atgctttatt cgcttccttc acgtgacatc attgcagata gcgtagaata
      481 tatggttaat gcgcacaagg cggatgcaat ggtatgtatc agtaattgcg ataagatcac
      541 tcccggaatg ttaatggcgg ctatgcgtct gaatatccct gccgtatttg tatcgggtgg
      601 tccgatggaa gcgggagaat ggaatggcca gcacctggat ttgatcgatg cgatgattaa
      661 atcggccgac gagagtgtta gcgatcagga agtagcgaat atcgagcaaa atgcttgtcc
      721 tacttgcgga tgctgctccg gtatgtttac cgccaactcg atgaactgcc tgaatgaagc
      781 aatcggactg gctcttcccg gcaacggaac cattgtagcg acacacgaaa accgtacgca
      841 acttttcaaa gacgctgcgg aactgatcgt gaaaaatgca aaattatatt atgaagaagg
      901 agacgaaagt gtacttcccc gtagcatcgc tacccgtcag gctttcctga acgccatgac
      961 gctggatata gcaatggggg gatctaccaa tacggttctt cacttgttgg ctgttgctca
     1021 cgaagcagag gtagacttca agatggatga tatcgacatg ctttcccgca aggctccttg
     1081 tctctgcaag gtggctccca atacacagaa atatcatatt caggatgtaa accgtgccgg
     1141 tggtatcatt gccattatgg acgaactggc aaagggaggt ttgatagata catccgttcg
     1201 tcgggtagac ggaatgtcac tggcagaagc cattaatgaa tattcaatca ccagcccgaa
     1261 tgtgagcgaa aaagcaatta agaaatattc gagcgcagcc ggaaataaat tcaatctcgt
     1321 acttggttca caaggtatgt actataagga actggataag gaccgtgcaa acggatgtat
     1381 tcgtgacttg gaacatgctt acagcaaaga cggcggactg gccgtattga aaggtaatat
     1441 tgctcaagat ggttgtgtag taaaaacagc aggtgtagac gaaagtatct ggaagtttac
     1501 cggacctgcc aaagtatttg attcgcaaga agcagcctgt gaaggcatcc tcggaggtcg
     1561 agtcgtcagt ggagacgtcg tcgtcatcac gcacgaaggt ccgaagggtg gtcccggtat
     1621 gcaggaaatg ctttatccta cctcttatat aaaatcccgt catctcggaa aagaatgtgc
     1681 tttgattacc gacggacgtt tcagcggtgg aacttccgga ttgagtatcg gacatatttc
     1741 tcctgaagcg gcagctggag gcaatatcgg aaaaattgta gacggagaca ttatcgaaat
     1801 cgatattccg gcccggaaga ttaacgtgcg actgacggat gaagaactgg cggcccgtcc
     1861 gatgactcct gttactcgtg accgttatgt accgaagagc ctgaaggcgt atgccagcat
     1921 ggtaagctct gccgataagg gagcagtgag aattatataa tatagttggt gatagttgat
     1981 aggtaatagt tagctgcgca gcacttagcg caatgattgt aaaccattca ttttcaactg
     2041 tcatttctca actatcattt atcatttatc aactatcaac taatatgaaa gatttaataa
     2101 caggtgcaga ggctttgatg cgctccttgg aacatcaggg agtgactacc atctttggtt
     2161 accccggtgg ttctattatg ccggtattcg atgccttgta cgatcatcaa aatatattga
     2221 accatatctt ggttcgtcac gaacagggag ctgcccatgc cgcacagggt tatgcccgtg
     2281 tatcgggtga tgtaggtgtt tgcctggtga cgagcggtcc cggagcaacc aatacggtaa
     2341 caggcattgc agatgcgatg atcgatagta cgcctatcgt ggtgattgcc ggacaggtag
     2401 gaacaggctt tcttgggacg gatgcttttc aggaagttga cttggtaggt atcacccagc
     2461 caatcactaa atggagttat cagattcgcc gtgcggaaga tgtagcctgg gcggtagcac
     2521 gtgcgtttta cattgctcgt agtggtcgtc cggggccggt ggtactggac tttgctaaaa
     2581 atgcgcaagt agagaaaacg aaatacgaac cgacgaaagt cgattttatc cgtagttatg
     2641 ttcctgttcc cgatacggat gaggagtctg tacaggctgc tgccgaactg attaataacg
     2701 ctgaacgtcc gcttgtattg gttggacaag gtgttgaact gggaaatgca cagagcgaat
     2761 tgcgtgagtt tatcgaaaaa gcggatatgc ctgcgggttg tacgctgctc gggctttcgg
     2821 ctttgccgac agaacatccg ttgaataaag gtatgttggg tatgcacggc aatctgggac
     2881 cgaatatcaa taccaataaa tgcgatgtgc tgattgctgt cggtatgcgt tttgacgacc
     2941 gtgtgaccgg taatttggct acttacgcca aacaggcaaa agtgattcat tttgatatcg
     3001 atcctgcgga agttaataag aatgtaaagg tagatgtagc tgtattggga gattgcaagg
     3061 aaacactggc ttctgtgacg aaacttctga aaaagaacac tcataccgaa tggattgata
     3121 gcttcaaaga atatgagaaa gtagaggagg aaaaagtaat ccgtcctgaa cttcatcctg
     3181 ccacaaactc tttgagtatg ggggaagtgg tacgtgcggt aagcaatgcc actcaacatg
     3241 aagcagtttt ggtaacagat gtaggtcaaa atcagatgat atctgcacgt tacttcaaat
     3301 atacgaaaga acgcagtatc atcacttccg gaggacttgg aactatgggc ttcggtcttc
     3361 ccgcagctat cggggcaact tttggagcac cggaacgtac cgtatgcgta tttatgggag
     3421 atggtggact gcaaatgaat attcaggagt tgggtacgat tatggagcag aaagctccgg
     3481 tgaaaattat ctgcctgaat aataattacc tcggaaacgt acgccagtgg caagctatgt
     3541 tcttcaatcg ccgctattcg tttactccga tgttgaatcc ggattatatg aaggttgctt
     3601 cggcttatga tattccttcc aaacgtgctt tcacccgtga agaactgaaa gaagctattg
     3661 cagaaatgct ggcgacagat ggtccgttcc tgctcgaagc gtgcgtagtg gaagaaggca
     3721 atgttttgcc aatgactcct ccgggtggtt cggtcaatca gatgctgttg gaatgctagg
     3781 agaagttgaa tattgagaat ggaagattga aagttcgcaa ttaaaattta ggattatgag
     3841 tgacaagaca ttatatacga taatagttca ttccgaaaat atagccggat tgctgaatca
     3901 ggtaactgct gtatttactc gtcggcaaat caacatcgag agtctgaatg tatctgcttc
     3961 ttctattaaa ggtgtacaca agtatacgat tacagctttg acggataagg acaccattga
     4021 gaaggtagtg aaacagatcg aaaagaagat cgatgtgatt caggcacatt atttcaccga
     4081 ggatgaaata tacttccatg agattgcact atataaggta tctactcctg cttttcagga
     4141 aactccggaa gcatccaagc tgattcgtag atacaatgca cgtatagtgg aagtcaatcc
     4201 ggtattttct attgtcgaga aaaatggaat gagcgaagat ataacttcgc tctatggtga
     4261 actgaaggct ttgaattgtg ttttgcagtt tgttcgttcg ggacgtgtag cgattactac
     4321 cagctgcttt gaacgggtga atgagtttct cgatggacgg gaagctatgt ataaccaaag
     4381 taagaaccaa taagaataat gagtgaagaa aatagaatag ggacttatca gtttgtggca
     4441 gaaccgttcc atgttgactt caacggacgt ctgactatgg gggtactggg aaatcatctg
     4501 ctgaattgtg caggttttca cgccaatgac cgtggttttg gtattgcaac gctgaatgag
     4561 gacaattata catgggtgct ttcacgtctg gctattgagt tggatgaaat gccttatcag
     4621 tatgagaatt tctcggttca gacgtgggtg gaaaatgtct accgtttgtt tacggaccgt
     4681 aattttgcta tcctcgataa ggatggaaag aagattggtt acgcccgttc cgtatgggca
     4741 atgattaatc tcaatacccg caagccggcc gacttgctga ccttgcacgg aggaagtatc
     4801 gtagactatg tttgtgatga accttgccct attgaaaagc cttcacgcat caaagtgaca
     4861 agcgatcagc cgatagctac cctgacggca aaatacagtg atatagatat taacggtcat
     4921 gtgaacagca tccgttacat cgagcatatc cttgatttgt tcccgattga gctgtataag
     4981 accaaacgta tccgtcgttt tgaaatggcg tatgtggcgg aaagctattt tggtgatgaa
     5041 ctctctttct tctgcgatga agtgaacgca agcgagtttc atgtagaagt gaagaagaat
     5101 ggcagcgaag ttgtttgccg ctcgaaagtg atatttgaat aaatgtgaga atataaaatc
     5161 aattaataac agatggcgta agtcatcaaa aactaaaaac aaaaagaaaa tggcacagtt
     5221 gaattttgga ggtactactg aaactgtagt aatccgtgac gaatttccat tggaaaaagc
     5281 tcgtgaagta ttggaaaatg aaacaatcgc tgtaatcggt tatggcgtac agggtcctgg
     5341 acaggcactg aacttgcgtg ataacggttt caatgtaatc gttggtcaac gtgaaggaaa
     5401 aacatacgat aaggcagtag cagacggatg ggttccgggt gaaactttgt tcggtatcga
     5461 agaagcttgt gagaaaggta ctattgtaat gtgtctgttg tctgacgcag cagtaatgtc
     5521 agtatggcct actatcaagc cttacctgac tgccggaaaa gctctttatt tctcacacgg
     5581 ttttgctatc acttggaacg accgtacagg tgtagtgcct cctgctgata tcgacgttat
     5641 catggttgct cctaaaggtt cgggtacgtc tttgcgtact atgttcctcg aaggacgtgg
     5701 cttgaactct tcttatgcta tctatcagga tgctacaggc aaggcttacg aaagaactat
     5761 cgcactgggt atcggtatcg gttccggtta tctgttcgaa acaactttcc agcgtgaagc
     5821 tacttctgac ttgacaggtg aacgtggttc attgatgggt gctatccaag gtttgttgct
     5881 ggcacagtac gaagtattgc gtgaaaacgg tcatagtcct tctgaagcat tcaatgaaac
     5941 agtggaagaa ctgacacagt cgttgatgcc gttgttcgca aagaacggta tggactggat
     6001 gtacgctaac tgctctacta ctgctcaacg tggtgctctc gattggatgg gcccattcca
     6061 cgatgctatc aaaccggtag ttgaaaagtt gtataacagt gtgaagactg gtaacgaagc
     6121 gcagatttct atcgacagta attcacaacc tgattatcgt gaaaaattga acgaagaact
     6181 ccgtcaatta cgcgaaagcg aaatgtggca gactgctgta actgttcgta aacttcgtcc
     6241 ggagaataat taattagact agattataca agttttaaaa gaaggagagg gctttttgct
     6301 ttctcctttt tttattaata agatatttaa aatgggtagg tgaaacttgc agaaactttt
     6361 ttttgaaaaa tatatcaata atgtgattaa aatatgcaag tttatgttta tatttgcacc
     6421 atcaaataaa atgaacgaga agtatgatgt gttttaactt accccaaaga atgattaaca
     6481 ttgctaaatt agcatgtgtt atcggtgttg tttctgttgt tttctcaagc tgtttacaga
     6541 aagatgtata tgatcctgct aattcaggag ataaagaaga agttacttta gataactatt
     6601 tcgactttgc cactactaag aatattcaat tgaatattga ttatggaaag gaatgtccta
     6661 gggcttattt tgaagtttat gctgaaaatc cgctttctta tgtggcagaa ggcggtcaga
     6721 ttataaagaa agcaggggtt tcacacattg caaccggatt tacagatata caaggacgtt
     6781 atatcaaacc ggcttctttc ccgacagcag tttcagaagt ttatatttat tctccggatt
     6841 ttggtgtgcc gactttgtat aaaactaaag ttgtcggttc ggatgtcagc gcaaaaataa
     6901 cctttgagaa tgctcttgat gtaactgctt tggattcatc aacgagaagt gcacaaacaa
     6961 gatcttcttt gaaatttatt acaaatgtaa ttccgaatgt attaggaact tggaatgtaa
     7021 atactggtag gcctaactat ctggatgctt ccaaaaaaat aaatgtggat gcaacgctta
     7081 agagttatat aacgacatat tttccggaag gaaagaataa taaaggaaca ttagtgtccg
     7141 atgatgcaga tattctgata acaaaagatg ccaatgttgt tattaactat tttggaggaa
     7201 atactgctgc acaaagtgta tttgcttatt attgttatcc taaggatgct tctgttgatg
     7261 agatgaggga ggctacaaag catgcatgtg tcatattccc taatgcacat ggaaatagtt
     7321 taggctatta tagtggagtt gcagttaatt tgaaatatat aagtaaggat ggtaaattcc
     7381 cgcaagatga tccggaacgt attccggcag acacaaggat tggtttttta atttggaata
     7441 atggctgggt aaatgctaag gctaatggaa atatgtttta ctcaactaaa gctttgaata
     7501 gtgatggaat ttctcacact gcaatttttg cagcagaaaa taaagcaggt gaaagagtga
     7561 atgtgattac aatggaagac tggaaaaacg gtgaaaatga ctataatgat gttgctttcg
     7621 ttatctcttc taatcctatt gctgctattg aagttccgga tgttcctaat ccgggtgatc
     7681 gacaaggaac agaaaagtat tctggagtgc ttggctttga agataactgg cctgaacaag
     7741 gagattatga cttgaatgat gtagtcatga aatatcagtc aagtgttgat tataatatag
     7801 ataataaagt tcttaatatt attgataagt tcacattggc ttggacggga gctaattata
     7861 aaaactcgtt tgcgtatgag gttcctttcg atttgagtaa agcgtcccaa gtaataatca
     7921 atggcgatga aattacttcc tattcaggta atgtgataac attattcaag gatgctaaag
     7981 ctgaattggg agtatccaat gtgaatgcgg aggatatgat taatcagaat attcaagaga
     8041 agacatatac ggtatccata caatttaata accctactct tgataaatca gtggtggtag
     8101 ctccttataa cccttttata aaagtattca actctgccac agaagtccat ctgacagatc
     8161 ataagccgac gactggtgcg aataatcgtt tcccttccgg agctgatatt tctcgtggtg
     8221 atgtagatgg tacctatttc atttgcaaag atggttttcc gtttgcaatt catgtagatg
     8281 ctcgtttgga cgcttctatt ttgaatttag atcttaaaaa ggagaatcag cgcattgata
     8341 aaacatatcc taaatttgca gaatgggcaa aaacgcgcga tccgcaaata aaatggtgga
     8401 aatagttgga gtgcattgga ataatcgact atctttgagg gtgaaaaatt aagaatagta
     8461 ctgatgtaaa atattgtttg ttttgtttgt gttaaaaaaa gtgtggtttc gggagaaagt
     8521 gtgctttgtt aaaaggagga ttaagtattt aatcctcctt tttaatgaat aacatcaacc
     8581 ttttatagaa aggatgcttg gcaagggtgg aggtatctcc taatataaca agtttcattc
     8641 gtgcccgcgt aatcgctaca ttcattcttc gcaagtcatt tagaaacccg atttgtccgt
     8701 cctcgttggc acgtacgaga ctgatgaaaa taacgtctcg ctcctgtccc tgaaagccgt
     8761 ctaccgtatt cacggtgatg aggctgcgga aagggcgtaa aaagctgctt ccttttattt
     8821 ttcctctcaa atattgcact tgtgccttgt atggcgaaat cagaccgaaa tcaattcttt
     8881 catccagtat tcgctctttg ccgatacgtt cgatgtaagt ttccagttct tgcagtagta
     8941 ggttggcttc ctgcttattg atgcgtccga agctttctcc tacaaaatct tcgtgaaagt
     9001 ccatctctga agtatcgatc cagttcatgg gagtgtcgaa atcaagaatc ccccgatagc
     9061 gtacttccgg agcagcttcc agttctccgt gataaaacca gtcggaggga aactgcatga
     9121 tggtttcatg cattctgtac tgtactttta atagagagac cgcggaaggt ttttgttgaa
     9181 cgactttttc cattaatgta tgatccaatc ctccacggga agcttctata catttgatag
     9241 tcggcggaag ctgacaatga tctcctgcaa ggatgacccg gtctgctttg cggatagcga
     9301 tccagcaggc agcttcgagg gcttgtgcag cttcgtcgat gaataaagtc gaaaaacgac
     9361 gtccgttgag caggcggtgg ttgctgctga ctagggtaga agcaatcaca cgggcactgt
     9421 cgaaaagatc ggcattgatt tgtatttcca actccgtggc acggtcgcgg agacgactca
     9481 tgcgattacg cattccttcc cgttcagaat aactaccccg gcgcatccgg ctacccattt
     9541 cgcggataga tttacggatt ccccaaagct ccggataggc aggatgactt tcaaaccggc
     9601 gttcgtaggt ggatgaaagc attttgtcgt tgactcgggt cggatttcca atgcggagca
     9661 cgggtactcc ccggtctacc agtttctcac aaatccagtc gacagccgtg ttgctttgtg
     9721 cacagacaag cacttgtggt tcccggtgta acgtttcgta aatcgcttcg acaagagtcg
     9781 ttgttttccc ggttcccgga ggaccgtgaa caatagatac gtcacgtgta catagcacct
     9841 tgttgactgc tgtttcctgt gtactgttca gccatgggaa gcggacagga tataattcgc
     9901 ggaatcccgg cttttgggta cccaacaaaa tgtcgcgcag ttccgccagg cggttgtcct
     9961 tggcacgtat cgtgtcttcc agtgcctcga acatggcccg gtacgatgtt tcgtcaaaat
    10021 aaagttgtac tcccagtata ccgtcagttt gcagttccgc taaagctccc gctccgggga
    10081 gtacaacgac cattcgttct tcgtcggcaa agctgatggt agcgatgaaa tccatatact
    10141 tcacttttcc ttcgaatgac tggtggaaaa agcaaacagg acggccgaac tcaaaggaat
    10201 gctctatttc tttattttcg gtccgtgtaa tatctattac aagctgattc agcgaattgt
    10261 agtaacttcg gccaagagag acaggatacc agcagagacc gcgcttcact ttacgggcaa
    10321 cgcccattgt ttcggtctgc cgcttaaatt cttccttctc atattcatac tccatccgca
    10381 ggaggagttg ctgttgctga aggtctataa tgggactttt cggattatta ctcataatag
    10441 gcgcaaaggt aacaaatctt cgttccgggt agaaaaaata tttcattttg ttaaacatta
    10501 ctcgaacgtc gttcgttatt ttaatagata gactaaaaaa acaaaaagca atatggtata
    10561 tgatgtgact atgttagaag ctttctacgc tgcttataaa ggaaaggtag aacacgtacg
    10621 ggctatacta aaacgccctt tgacgttggc cgagaagatt ttgtatgctc atctgtatga
    10681 tgtagccgat ttgaaagatt acaaacgggg ggaggattat gtgaatttcc gtcccgatcg
    10741 tgtggctatg caggatgcaa ctgcgcagat ggctttgctt caatttatga atgcaggtaa
    10801 ggatcaggtg gctgtgcctt cgacagtgca ttgcgatcac ttgatacagg cgtataaagg
    10861 tgcaaaggcg gatattgcta cggcaagact gaccaatgaa gaagtatacg atttcctccg
    10921 tgatgtatct tcccgttatg gcatcggctt ctggaaaccg ggagcaggaa ttatccatca
    10981 ggtagtgctc gaaaactatg ctttccccgg cggtatgatg gtgggaacag actctcatac
    11041 gcctaatgca ggcggactgg gcatggtggc tatcggtgtc ggtggagcgg atgccgtgga
    11101 tgtgatgaca ggaatggaat gggagctgaa aatgccgaag attatcggtg tccgtctgac
    11161 cggaaaacta agcggttgga cctctccgaa agatgtaatc ctgaaattgg ccggcatcct
    11221 taccgtaaaa ggaggaacga atgctattat cgaatatttt ggtcccggaa ccgaatccct
    11281 ttctgctacc gggaaagcta ccatttgcaa tatgggtgcc gaagttggag ctactacctc
    11341 tttattcccg tttgacggac gcatggctac ttatttgaga gctaccggaa gagattgtgt
    11401 agtcgattgg gctgaatctg ttggtgcaga ccttcgtgca gacgacattg tgaccgacga
    11461 accatccaac tattacgacc gtgtgattga aattgacttg tcagaactcg aaccttatat
    11521 aaacgggccg tttacaccgg atgccgctac tcccatctct gaatttgcag aaaaagtgtt
    11581 attgaacggc tacccccgta aaatggaggt aggcttgata ggttcatgta ccaattcttc
    11641 ttatcaggat ttgagccgtg cagcttcttt ggcaaagcag gtgacagaaa agaatttgag
    11701 cgttgcttct ccgctgatcg tcaatccggg ttcggagcaa atccgggcta ctgccgaaag
    11761 agacggtatg attgaggctt ttgaacggct gggagccacg attatggcaa atgcttgtgg
    11821 accttgtatc ggtcagtgga aacgtcagac ggacgatccg acacgaaaaa actcaatcgt
    11881 cacctctttc aatcgtaatt ttgccaaacg cgctgacggt aatcc
//
