LOCUS       c00012_gnlPro..        14971 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|LNOAIPPO_12.
ACCESSION   c00012_gnlPro..
VERSION     c00012_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-05 00:40:37
            Original ID  :: gnl|Prokka|LNOAIPPO_12
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 16132
            Orig. end    :: 31103
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14971
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[26132:29681](+)"
                     /cutoff="5000"
                     /detection_rule="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /neighbourhood="10000"
                     /product="PFOR_II_pathway"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..13549
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="5000"
                     /detection_rule="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /neighbourhood="10000"
                     /product="PFOR_II_pathway"
                     /protocluster_number="1"
     cand_cluster    1..14971
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /kind="single"
                     /product="PFOR_II_pathway"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14971
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="PFOR_II_pathway"
                     /region_number="1"
                     /rules="cds(POR and POR_N and PFOR_II and EKR and Fer4_16
                     and TPP_enzyme_C)"
                     /tool="gutsmash"
     CDS             441..3212
                     /locus_tag="ctg12_13"
                     /transl_table=11
                     /translation="MSENNYISIKGARVNNLKNIDVDIPRNKLVVITGLSGSGKSSLAF
                     DTLYAEGQRRYVESLSSYARQFLGRMSKPECDFIKGIPPAIAIEQKVNSRNPRSTVGTS
                     TEIYEYLRLLYSRVGKTYSPISGQEVKKHSTEDIVNCMLSYPEGTRYTVLTPIRLREDR
                     TLQQQLEIDLKQGFNRIEVNGEMKRIDEYTPVASDEVYLLVDRMAVATSKDAISRLTDS
                     AETAMYEGDGTCMLRFFLSDGTTKLHTFSTKFEADGIIFEEPNDQMFSFNSPIGACPAC
                     EGFGKVIGIDEHLVVPDRSLSVYEGAIVCWRGEKMGEWKEELIHNAEKFDFPIFTPYYE
                     LTDAQRRLLWEGNQYFHGINDFFKMLEENQYKIQYRVMLARYRGKTLCPKCHGTRLKPE
                     AGYVRVGGKNISELVDLPITELKEFFDHLELDEHDNNVSRRILVEINSRIRFLIDVGLG
                     YLTLNRLSNSLSGGESQRINLATSLGSSLVGSLYILDEPSIGLHSRDTDRLLHVLRQLQ
                     QLGNTVVVVEHDEEIIRAADYIIDIGPNAGRLGGEVVYQGDMKDLKKGSNSYTVRYLLG
                     EDEIPVPEHRRPWNNYIELKGARENNLKGVNVRIPLNVMTVVTGVSGSGKSTLVRDIFF
                     RALKRELDECSDRPGEFSSIGGSLRDLRNVEFVDQNPIGKSSRSNPVTYIKAYDEIRKL
                     WSEQPLAKQMGYTPGFFSFNSEGGRCEECKGEGTITVEMQFMADLVLECESCHGKRFKS
                     DTLEVKFNDKSIYDVLEMTVNQAIEFFNEHGQKKIVKKLLPLQDVGLGYIKLGQASSTL
                     SGGENQRVKLAFYLSQEKADPTMFIFDEPTTGLHFHDIRKLLDAFDALIRRGHSIVIIE
                     HNMDVIKCADYVIDLGPEGGDKGGNIVAVGTPEEVAACGASYTGQFLKEKLG"
     CDS             complement(3310..3795)
                     /locus_tag="ctg12_14"
                     /transl_table=11
                     /translation="MKKLALALCLLAVSFTAQAQFEKGTTIINPSLSGLDFSYSKNDKA
                     KFGVGAQVGTFFAEGIALMVNAGADWSKPVDEYTLGTGVRFYFNKTGIYLGGGLDWNRF
                     RWSGGKHQTDWGLGIEAGYAYFLSRTVTIEPAVYYKWRFNDGDMSRFGVKIGFGFYL"
     CDS             complement(3800..4030)
                     /locus_tag="ctg12_15"
                     /transl_table=11
                     /translation="MKKIRKSTGVALAFLIYVSVTAAYLLPRNTEVSLTEKIITVAVSY
                     VIVLLLWLVLRKKEQMRERRKKDEQSIHLKK"
     CDS             complement(4027..5457)
                     /locus_tag="ctg12_16"
                     /transl_table=11
                     /translation="MITFTLCLLALIVGYFTYGRLMERVFGPDDRKTPALTKADGVDYI
                     PLPTWKIFMIQFLNIAGLGPIFGAIMGAKFGSSSYLWIVLGSIFAGAVHDYFAGMLSLR
                     NGGESLPEIIGRYLGLTTKQVMRGFTVILMILVGSVFVAGPAGLLAKLTPESLDATFWI
                     IVVFAYYILATLLPVDKIIGKIYPLFAVALLFMAVGILVMLYVNHPALPELWDGLQNTN
                     PEASELPIFPIMFVSIACGAISGFHATQSPLMARCMTSERHGRPVFYGAMITEGIVALI
                     WAAAATYFFHENGMEESNASVIVDAITKEWLGAIGGVLAILGVIAAPITSGDTAFRSAR
                     LIVADFLGMEQKSMRRRLYICIPMFVVAIGLLLYSLRDANGFNMIWRYFAWANQTLAVF
                     TLWAITVFLAVSKKPYIITLVPALFMTCVCSTYICIAPEGLGLSHTVSYGVGIACVMVA
                     TVWFYIRINKQKTRKLSE"
     CDS             5567..7033
                     /locus_tag="ctg12_17"
                     /transl_table=11
                     /translation="MRYTIFILSLLFPFLSIVAQPKHEVRAAWVTAVYGLDWPRTRATT
                     PQTIRKQKEELIDILDKLKAANFNTVLFQTRTRGDVLYPSAIEPFNSILTGKTGGNPGY
                     DPLAFAIEECHKRGMECHAWMVTIPLGNKKHVASLGSQSVTKRMKEICVPYKREYFLNP
                     GHPATKEYLMKLVREVVSGYDVDGVHFDYLRYPENAPLFPDKYDFRRYNKGRTLDQWRR
                     DNISEIVRYIYKGVKAMKPWVKVSTCPVGKYRDTSRYPSRGWNAFFTVYQDPQGWMGEG
                     IMDQIYPMMYFQGNNFYPFALDWQEQSNGRQVIPGLGIYFLHPDEGKWTRDEIDRQMNF
                     IRKQKMAGEGHYRVKYLMENTQGIYDELSENFYAYPALQPPMPWLDNVAPTAPSALKIT
                     HIDNGYTELTWQAATDNDQRNKPMYVIYASNDYPVDINRPENIIAQNIRETSYVYAPIL
                     PWNTKKHFAVTAIDRYGNESTETQEQTDQQ"
     CDS             complement(7425..8627)
                     /locus_tag="ctg12_18"
                     /transl_table=11
                     /translation="MTKKALYIFNPEHDLALASGETNYMAPASARRMASELALLPMWYA
                     EEGSAVLAPSAYNLGYVKKIQELLGLSVDLMTEPELAIEPNLDIRPWGWDVALRKRLSG
                     LGMDEALLPSMEQLDGLREYSHRSKAVSLLPELQLNEYFCGESYYLKTQEEWKTFVEER
                     ECCLLKAPLSGSGKGLNWCKGIFTPFISGWCTRVAASQGGIIAEPIYNKVEDFAMEFYS
                     DGTGEVTFMGYSLFHTGKSGMYEGNRLLSNEAIWKQLSQYVPSKVLTDLENCLKYRLSA
                     LVGTVYKGYLGVDMMICRFPENEKPVFRIHPCVEINLRMNMGVVARFLYDRYVRSGSTG
                     RFVIDYHPSEGEALQEHERMSATYPLEIREGRVYSGYLPLVPVHRRSCYRAWIWVTPDN
                     I"
     CDS             8859..9968
                     /locus_tag="ctg12_19"
                     /transl_table=11
                     /translation="MDEIDWSDRLIGIKGTRGVGKTTFLLQYAKEKFGNDRSCLFINMN
                     NFYFSGHSIVDFANEFQKRGGKVLLIDQVFKHPEWSKELRMCYDRFPNLKIVFTGSSVM
                     RLKEENLELRDIAKSYNLRGFSFREFLNLQTGMKFRAYSLEEILSTHEQIAKGVLSKVR
                     PLDYFQDYLHHGFYPFFLEKRNFSENLLKTMNMMVEVDILLIKQIELKYLSKIKKLLYL
                     LAVDGPKAPNVSQLASDIQTSRATVMNYIKYLADARLINLVYPKGEEFPKKPSKIMMHN
                     SNLMYSIYPVKVEEQDVLDTFFANSLWKDHKVHKGDKNVSFMVDEVMPFKICQEGAKIK
                     NNPNVTYALHKAEIGRGNQIPLWMFGFLY"
     CDS             10001..13549
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: TPP_enzyme_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: Fer4_16"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: EKR"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: PFOR_II"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: POR_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: POR"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg12_20"
                     /sec_met_domain="PFOR_II (E-value: 1.2e-18, bitscore: 57.9,
                     seeds: 27, tool: rule-based-clusters)"
                     /sec_met_domain="POR_N (E-value: 1.4e-82, bitscore: 267.4,
                     seeds: 31, tool: rule-based-clusters)"
                     /sec_met_domain="POR (E-value: 1.3e-31, bitscore: 100.6,
                     seeds: 86, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 2.7e-12, bitscore:
                     37.3, seeds: 323, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_16 (E-value: 5.1e-12, bitscore: 37.2,
                     seeds: 227, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4 (E-value: 9.2e-08, bitscore: 22.4,
                     seeds: 528, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 5e-05, bitscore: 14.4,
                     seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="EKR (E-value: 3.1e-25, bitscore: 78.4,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTKQKKFITCDGNQAAAHISYMFSEVAAIYPITPSSTMAEYVDEW
                     AAAGRKNIFGETVLVQEMQSEGGAAGAVHGSLQAGALTTTYTASQGLLLMIPNMYKIAG
                     EFLPCVFHVSARTLASHALCIFGDHQDVMSARQTGFAMLAEGSVQEVMDLAGVAHLATI
                     KSRVPFMNFFDGFRTSHEIQKIEMLENDDLAPLIDQEALAEFRARALNPMKPVARGMAE
                     NPDHFFQHRESCNNYYEAVPAIVEEYMNEISKITGRKYGLFDYYGAEDAERVIIAMGSV
                     TEAAREAIDYLVANGEKVGMVAVHLYRPFSAKHFLAAVPKTAKTIAVLDRTKEPGANGE
                     PLYLDVKDCFYGAENAPVIVGGRYGLGSKDTTPAQILSVFENLAMPMPKNHFTIGIVDD
                     VTFTSLPQKEEIALGGEGMFEAKFYGLGADGTVGANKNSVKIIGDNTDKHCQAYFSYDS
                     KKSGGFTCSHLRFGDNPIRSTYLVNTPNFVACHVQAYLHMYDVTRGLRKNGSFLLNTIW
                     EGEELAKNLPNKVKKYFAQNNISVYYINATQIALEIGLGNRTNTILQSAFFRITGVIPV
                     EQAVEQMKKFIVKSYGKKGEDVVNKNYAAVDRGGEYKTLAVDPAWANLPDDAKAENNDP
                     AFINEVVRPINAQDGDLLPVSAFKGIEDGTWYQGTAKYEKRGVAAFVPEWNAENCIQCN
                     KCAYVCPHASIRPFVLDAEEQKGAKFEQLKAVGKAFDGMTFRIQVDVLDCLGCGNCADI
                     CPGNPKKGGKALTMKHLESQLAQAENWTYCAENVKTKQHLVDIKANVKNSQFATPLFEF
                     SGACSGCGETPYVKLISQLFGDREMVANATGCSSIYSGSVPSTPYTTNENGHGPAWANS
                     LFEDFCEFGLGMELANEKMRARLVKVMNEAIAADCTPAEVKELFAEWINNMLDADKTKE
                     LAAKIIPVVEANKDKCNHCKQIAELQQYLVKRSQWIIGGDGASYDIGYGGLDHVIASGK
                     DVNILVLDTEVYSNTGGQSSKATPVGAIAKFAAAGKRVRKKDLGLMATTYGYVYVAQIA
                     MGADQAQTLKAIREAEAYPGPSLIIAYAPCINHGLKAGMGKSQEEEEKAVKCGYWHLWR
                     YNPALEEEGKNPFQLDSKEPNWEDFQGFLKGEVRYASVMKQYPTEAEELFKAAEENAKW
                     RYNSYKRLARENWGAE"
     CDS             complement(13702..14568)
                     /locus_tag="ctg12_21"
                     /transl_table=11
                     /translation="MRIYKIVGIVLSAMLLLASCTNSGLEKKKVKIAYANWLEGIAMSH
                     LAKVVLEEHGYEVELQNADLAPIFVSMSGKKSDVFLDAWLPITMKDYMDQYGDSIEFLG
                     EVYGEARVGLVVPQYVTIQSISELEANKDRFSSEIVGIDAGAGIMKTTDKAIAAYGLDG
                     YTLMTSSSSTMLASLKKAMDKGEWIVITGWTPHWMFDQFDLKFLDDPKKVYGDLEEIHA
                     IAWKGFSEKDPFAAEFFGNIKLTTEELSSFMTAMKDARMDEEEIARKWRDEHRQLVDSW
                     IPKSENK"
     CDS             complement(14589..14969)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) BPD_transp_1"
                     /gene_functions="transport (smcogs)
                     SMCOG1004:Binding-protein-dependent transport system inner
                     membrane component (Score: 67.6; E-value: 4e-21)"
                     /gene_kind="transport"
                     /locus_tag="ctg12_22"
                     /sec_met_domain="BPD_transp_1 (E-value: 1.4e-21, bitscore:
                     67.6, seeds: 81, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="PGVFATIIFAMPPVVRLTGLGIRQVPKNVVEASRSFGATRWQLLY
                     KVQLPLALPTILTGVNQTIMMSLSMVVIAAMIAAGGLGEIVLKGITQMKIGLGFEGGIA
                     VVILAIILDRITQGMAGRKNKN"
ORIGIN
        1 cttcaatcat aaactgcatc gggtcccaca taggagaagg tgtctgccct tgcgttcctg
       61 tcaggaagcg gctccacggt tcatattggg aagcgtataa tgcatccgct tcaggacgca
      121 cctgaaagat gatcgcatta attccggctt cctgaagaga attcaactga ctaatcaata
      181 tttgcttcag tcgctctgtg ggaatgccac gaaactggcc attgacagcc tgtatccatg
      241 ctccacggaa ttcacgttta ggatatttat tgcctgatgg cacctgtgcc ctcactccta
      301 ccaccagaag aagagctaaa agtaaaagat agtttttcag cttcataata ttcttaaatc
      361 gtaataatgt gacgcaaaga taatacaaac tcccgataaa ttcgctaact ttgccgacta
      421 ccataaaaaa ggagtatttt atgtcagaaa acaactatat ttcgatcaaa ggcgcacgag
      481 tcaataacct aaaaaacatc gatgtagata ttccccgcaa caaacttgtt gttatcaccg
      541 gattgtcggg ttcgggaaaa tcatcacttg cttttgatac cctttatgca gagggacaac
      601 gccgctacgt agaaagctta agcagctacg cgcgtcagtt cctggggaga atgagcaaac
      661 cggagtgtga ctttatcaaa ggaattcctc ccgccattgc catcgaacaa aaagtaaaca
      721 gccgtaatcc ccggtctacg gtgggcacct cgactgaaat ttacgaatat ctacgcctgt
      781 tatattcacg ggtgggaaaa acgtatagtc ccatcagcgg gcaggaagtg aagaagcact
      841 ccacagagga catcgtcaac tgtatgcttt cctatccgga aggcacaaga tatacggtac
      901 tgacgcctat ccgcctgcgt gaagaccgca cattacaaca gcaattggag atagacctga
      961 aacaaggatt caaccgtatc gaagtgaacg gtgaaatgaa acgaattgat gaatatacgc
     1021 ctgtggcaag tgatgaagtc tatctgctgg tcgaccgtat ggcggttgcc accagcaagg
     1081 acgccatcag ccgactgaca gattctgccg aaacagccat gtatgaaggc gacggaacct
     1141 gtatgctgcg tttttttcta tcggatggaa ctacgaaact tcatactttc agcactaaat
     1201 tcgaagcgga cggcatcatc tttgaagaac cgaacgacca gatgttttca ttcaactcgc
     1261 ctatcggcgc ttgtccggcg tgcgaaggat tcggcaaagt aatcggcatc gacgagcact
     1321 tagtcgttcc ggatcgttca ttatcggtgt atgaaggagc tatcgtatgc tggcgtggcg
     1381 aaaagatggg tgaatggaaa gaagaattaa ttcataatgc ggagaaattc gacttcccca
     1441 ttttcactcc ttattatgag ttgacagacg cgcaacgcag gttactttgg gagggcaatc
     1501 aatatttcca cggcatcaat gattttttca agatgctgga agagaatcaa tataagatac
     1561 aataccgggt gatgctggcg cgttaccggg gaaagacgct ttgcccgaaa tgccacggca
     1621 cccgcctgaa accggaagcc ggatatgtac gagtgggtgg aaaaaacatt tccgaactgg
     1681 tagatttgcc tatcacagag ctgaaggaat tcttcgatca tttggaactg gacgaacacg
     1741 acaacaacgt atcccgacgt atcctggttg aaataaatag ccggattcgt tttctaattg
     1801 atgtaggttt gggctatctg actttgaacc ggcttagtaa ttccttatcg ggtggagaga
     1861 gccagcgtat caatctggca acctcgctgg gaagtagcct tgtaggtagt ctttatattc
     1921 tcgatgaacc aagtatcgga ctgcatagcc gtgacacaga ccgtctgctc catgtgttgc
     1981 gtcaactgca acaattagga aatacggtag tggtggtaga gcacgatgaa gaaattatcc
     2041 gtgcagccga ttacattatc gacataggtc ccaatgccgg acgcctaggt ggagaagttg
     2101 tttaccaggg agatatgaag gatttaaaga agggaagcaa cagctatacg gtacgttatc
     2161 ttttaggaga agatgaaata cctgttccgg agcatcgccg cccgtggaat aattatatag
     2221 aattgaaagg cgcacgtgag aataatctga aaggagtaaa cgtacgtatc cctctcaatg
     2281 taatgacagt tgttacgggt gtttccggtt ccgggaagag tacattggtg agagatattt
     2341 tcttccgggc attgaaacgt gaattagacg aatgtagcga ccgaccggga gaattctctt
     2401 caatcggagg aagtttgcgt gacctgcgga atgtagaatt tgtagaccag aacccgattg
     2461 gcaaatcatc gcgctcaaat ccggtgactt acatcaaggc ttacgacgaa atccgtaaac
     2521 tatggtccga acaacctttg gcgaagcaaa tgggatatac ccccggattc ttcagtttca
     2581 atagcgaagg cggacgttgc gaagagtgta aaggagaagg aaccattact gtagaaatgc
     2641 aatttatggc agacttggta ttggagtgtg aatcttgtca tggaaaacgc ttcaaatccg
     2701 acacgctgga agtgaaattc aacgataaaa gtatctacga tgtattggag atgaccgtca
     2761 accaagcgat tgagttcttc aacgaacatg gacagaagaa aattgtgaag aagttgcttc
     2821 ctttgcagga tgtaggactg ggatatatca aattaggaca ggcttcttct accctttccg
     2881 gtggtgaaaa ccaacgtgtc aaactcgcat tttatttaag tcaggagaaa gctgacccaa
     2941 cgatgtttat ctttgacgaa ccgactacag gattacactt tcatgatatc cgcaaactgc
     3001 tggatgcttt cgacgcattg attcgccggg gacacagcat cgttatcatc gagcataaca
     3061 tggacgtcat caaatgtgcc gattatgtaa tcgatctcgg accggaaggt ggagataaag
     3121 gcggaaatat cgtagcagtg ggtaccccgg aagaagttgc tgcctgcgga gcaagctata
     3181 cagggcagtt tctgaaagaa aaactaggat aagcaatcgt caaaactata ataatacatt
     3241 tatgtaatta agcccttgca gaagttctat atctgcaagg gcttaatata tgaaaaaaat
     3301 caatctctct tacaagtaga aaccgaatcc aatcttcaca ccgaaacgtg acatatctcc
     3361 atcattgaaa cgccatttat aataaacggc aggttcaatg gttaccgtac gcgaaagaaa
     3421 gtaagcgtat ccggcttcga tacccagtcc ccagtctgtc tgatgttttc caccactcca
     3481 acggaagcgg ttccagtcga gtccaccacc cagatagata ccggttttat tgaagtagaa
     3541 gcgtactcct gtgcccagtg tatactcatc taccggtttc gaccagtcgg ctccggcatt
     3601 taccatcaag gcaataccct cggcaaagaa tgtaccgacc tgtgcaccaa ctccaaactt
     3661 tgctttatcg tttttactat acgaaaagtc caaccccgac aatgaaggat taataatcgt
     3721 agttcctttc tcaaattgcg cttgtgcagt aaaagagact gccaataagc aaagagccaa
     3781 agctaatttc ttcataaact tactttttta agtgaataga ttgttcgtct tttttgcggc
     3841 gttcgcgcat ttgttccttt ttccgaagca ccagccaaag aaggaggacg atgacataag
     3901 aaactgccac cgtaattatt ttctctgtca ggctgacttc cgtattacga ggcaacaaat
     3961 aagccgctgt tacggataca taaataagga atgcaagcgc cactcctgtt gattttctta
     4021 ttttcttcat tctgataatt ttcttgtttt ttgcttattt atcctgatat agaaccaaac
     4081 agtcgcaacc attacacacg ctataccaac gccataggag actgtatgcg agagtcctaa
     4141 tccttcagga gcaatacata tataagtaga acatacacat gtcataaaca gtgccggtac
     4201 caaagtaatg atataaggtt tcttggatac cgccagaaaa actgttatag cccacaaggt
     4261 aaacacagcc aatgtctgat ttgcccaggc aaaataacgc catatcatat taaatccgtt
     4321 tgcatcacgc aaactataca aaagcaaacc aatagctact acaaacatcg gaatacaaat
     4381 gtacaaacga cggcgcatac ttttttgctc catccccaag aaatctgcca caatcagacg
     4441 ggcagaacgg aaggccgtat ctcccgaagt tatcggagct gcaatcactc ccaaaatggc
     4501 aagtactccg ccgattgctc ccaaccattc ttttgtaata gcatcaacga taacagaagc
     4561 attgctttct tccattccgt tttcatggaa aaaataagta gcggcagcag cccaaataag
     4621 agcaacaatg ccctcggtaa tcattgcacc gtaaaatacc ggacgtccat gccgttccga
     4681 agtcatacaa cgggccatca atgggctttg cgtagcatgg aaacctgaaa tggcaccaca
     4741 agcaatactc acaaacataa tcgggaagat aggaagttcg ctcgcttccg ggttagtatt
     4801 ttgcaatccg tcccataact ccggcaaagc cggatggtta acatagagca tcaccaaaat
     4861 gcctactgcc ataaacaaca aggcaaccgc aaacaatggg tagattttac ctattatttt
     4921 atcaacaggc agcaaagtag ccagaatata atatgcaaat acaacgataa tccaaaacgt
     4981 agcatccaaa ctttccggtg tcagtttagc caacaatccg gcaggacctg caacaaaaac
     5041 cgaacccacc agaatcatta aaatgacagt gaatcctctc atcacctgct tggtagtcag
     5101 tcccaaatag cggcctatta tttccggcag gctttcacct ccattacgca aagaaagcat
     5161 tccggcaaaa taatcatgca ctgcccccgc aaaaatactt cccagcacaa tccacaagta
     5221 tgaagagcta ccaaatttcg ctcccatgat tgctccgaaa ataggaccta atccggcaat
     5281 attgagaaat tgaatcatga aaatcttcca ggtgggcaat ggaatatagt ccactccatc
     5341 cgccttggta agagccggtg ttttacggtc gtcaggacca aagacgcgtt ccatcaggcg
     5401 tccatacgta aaatagccta ctatcaacgc cagcaggcat agagtaaatg taatcatagc
     5461 gtgtcgtttt tttaacttgg caaatgtaac ataatctcac gaaacagccc aacaataccg
     5521 acacttttac taactttgca gggatttaaa acaaaaaata aaggatatgc gctatactat
     5581 tttcattctt tcacttttgt ttcctttcct ctcaattgtt gcgcaaccca agcacgaagt
     5641 tcgtgccgca tgggtgacag cggtgtacgg actggattgg cctcgcacac gtgcaacaac
     5701 ccctcaaaca atccgcaagc agaaagaaga gttaatagat attcttgata agttaaaggc
     5761 tgccaacttc aacactgtcc tatttcaaac ccgtactcgt ggagatgtat tatatccttc
     5821 ggcaatcgaa cctttcaatt cgatcctgac cggaaagaca ggaggaaatc caggatatga
     5881 tccactggct tttgccattg aagaatgtca taagcgaggg atggaatgtc atgcctggat
     5941 ggtaactatc ccactaggga ataagaagca tgttgcttcg ctcggcagtc agtctgtcac
     6001 caagcggatg aaagaaatat gcgttcctta caagcgcgaa tatttcctca atccgggaca
     6061 tccggcaacg aaggagtatt tgatgaaact ggtgcgggaa gtcgttagcg gttatgatgt
     6121 ggacggagtg catttcgact atctgcgtta tccagagaat gctcctcttt ttcctgataa
     6181 atatgatttc cgccgatata ataaaggacg caccctagat cagtggcgcc gggataatat
     6241 ctccgaaatt gtacgttata tatataaagg tgtaaaagct atgaagcctt gggtgaaagt
     6301 aagtacctgc ccggtaggta aataccgtga tacttctcgt tacccctccc ggggatggaa
     6361 tgctttcttt accgtttatc aggacccgca aggttggatg ggagaaggta ttatggatca
     6421 aatttatccg atgatgtatt ttcagggaaa caatttctac ccttttgccc tcgactggca
     6481 ggaacagagc aacggacggc aggtgattcc gggactcggc atttattttc tccatcccga
     6541 tgaaggtaaa tggacacgcg acgaaataga tcgtcagatg aactttatcc gcaagcagaa
     6601 aatggcgggt gaagggcatt accgggtgaa atacctgatg gagaatacac agggtattta
     6661 tgatgaatta tccgagaatt tttatgcata ccctgcttta cagcctccga tgccttggtt
     6721 agataatgtt gcgccaactg ctccttctgc actgaaaatt actcatattg ataatggata
     6781 tacggaatta acctggcaag ctgctactga taacgatcag cgcaacaagc ccatgtatgt
     6841 tatttatgct tctaacgatt atccggtaga tatcaaccga ccggaaaata tcattgcgca
     6901 aaatatccga gaaactagtt acgtgtatgc ccctatcctg ccgtggaata caaaaaagca
     6961 tttcgcagtg accgctattg accgctatgg aaatgaaagt acagagacac aggaacaaac
     7021 ggatcagcag taaacctggt atttagaatc gacttattgt ttcaaaacgg tatagaaatg
     7081 agtgaaacgg tgcagaaatg aactgatccg cacggaaaga aattaaataa tatagtttag
     7141 atttttctcc actgtataaa caatctatct gagacccggg tctcagcatc tatgacaccc
     7201 gggtctcagg tatgccaaca cccgggtgtc agtaccattg agacccgggt gtcagataga
     7261 actctactac taagcgtttt ttctttgtta ctagagtaaa taaaattccg atgcatctaa
     7321 tatctattca aatccggtgc aaaaaggaat atatttagac gcggattaca cggcagaagc
     7381 gacattgaag cagatcgacg ataaaggcta tctgataccg taagttaaat attatcagga
     7441 gttacccata tccacgcccg ataacaactt ctcctatgaa caggaaccaa aggtaaataa
     7501 ccggagtaca ctctaccttc cctgatttcc aacggataag ttgcagacat tcgttcatgt
     7561 tcctgcaagg cttcaccttc cgaaggatga taatcaatca caaaacgccc tgttgaacca
     7621 gaacgtacat aacggtcata taaaaaacgc gcaacaactc ccatattcat gcgcagatta
     7681 atttccacac agggatgaat ccgaaaaacc ggcttttcat tttccggaaa ccgacaaatc
     7741 atcatatcaa ctccaagata acctttataa acggttccta ccaacgcaga aagtctgtat
     7801 ttcaaacagt tctccaaatc cgtcagaacc tttgaaggga catattgcga aagttgtttc
     7861 cagattgcct cattagaaag caaacgattc ccttcataca ttccactctt tccggtatgg
     7921 aagagagaat atcccataaa tgtcacttca cctgtaccat cggaataaaa ctccatggca
     7981 aagtcttcta ccttattata tataggttcc gcaatgattc caccctgcga agcagccaca
     8041 cgcgtacacc aaccggaaat aaaaggagta aatatgcctt tacaccagtt caagccttta
     8101 ccgcttcccg aaagcggagc tttcaacagg cagcattccc gctcttccac aaaggttttc
     8161 cattcttctt gtgtcttcaa ataataagat tctccgcaga aatattcatt cagttgtaat
     8221 tccggaagca atgagacggc tttagaacga tgggagtatt cccgcaaacc gtctaattgc
     8281 tccatagaag gaagcagggc ttcatccatg cccagccctg aaagccgttt ccgcaaagct
     8341 acatcccatc cccaaggacg aatatccaaa ttcggttcaa tagcaagttc cggctctgtc
     8401 atcaaatcaa ccgaaagtcc taataattcc tgtatcttct tcacatagcc gagattataa
     8461 gcggaaggag ctaatacagc actcccctcc tctgcatacc acatcggaag caaagccaac
     8521 tcggaagcca tacgtctggc agaagccgga gccatataat ttgtttcacc gctagccaac
     8581 gccaagtcat gttccggatt gaatatataa agagcctttt ttgtcatttc aaatgaattc
     8641 aaaactttat tctgcaaata tatacaggaa atagtcagga atgactacaa taaacagaaa
     8701 gttggaatta aacacacaat tttgccatct ctactttgca aatcctaaaa aaagcagtat
     8761 atttgccacc cgaaaaacaa agaactgaaa tggaatcatt ctaccgcaca cacgcctacc
     8821 tcgttgagca caccaatgcc cccgttcgcc gcgatcttat ggacgagatc gactggagcg
     8881 accgcctgat tggtatcaaa gggacacgtg gcgtaggaaa aaccactttc cttctccaat
     8941 acgccaaaga gaaattcggg aacgaccgtt cctgtctgtt catcaacatg aacaacttct
     9001 atttctcggg ccacagcatt gtagacttcg ccaacgaatt tcagaaacgt ggcggaaaag
     9061 tattgttgat cgaccaggtg ttcaaacatc cggaatggag caaagagtta cgcatgtgtt
     9121 acgaccgttt tcctaacctg aaaattgtct tcaccggctc gtccgtgatg cgactgaaag
     9181 aagaaaatct tgaattacgt gatatcgcca agagctataa cctgcgtgga ttctctttcc
     9241 gtgaattcct aaacttgcaa acaggcatga aattcagggc atatagcctc gaagaaattc
     9301 ttagcactca cgaacagatt gccaaaggag tactctccaa agtccgtccg ttggattatt
     9361 ttcaggatta tctgcaccac ggattctatc cgttcttcct tgaaaaacgt aacttttcgg
     9421 agaatctgct gaaaacgatg aacatgatgg tggaagtaga tatacttctc atcaaacaaa
     9481 ttgaactgaa atatctttca aagataaaaa aattgctata tttgctcgct gtcgacgggc
     9541 cgaaagctcc aaatgtgagc caactggcaa gcgacataca gacatctcgc gccacggtga
     9601 tgaactatat caagtatctg gcagatgcgc gactcattaa tctggtttat ccgaaagggg
     9661 aagaattccc taaaaaacct tcaaagataa tgatgcacaa ctccaacctg atgtattcca
     9721 tctatccggt gaaagtggaa gagcaggatg tgctcgacac attctttgca aattctttat
     9781 ggaaagacca taaggtacat aaaggagata aaaacgtctc ttttatggta gacgaagtaa
     9841 tgccgttcaa aatttgccag gaaggcgcaa agatcaagaa caatccgaat gtaacgtacg
     9901 cgttgcataa ggctgaaata ggtcggggca accagatacc tctctggatg ttcggctttt
     9961 tatattaaaa gatttattta cttaaatatt taatttagtt atgactaaac agaagaaatt
    10021 catcacttgt gatggtaacc aagctgcagc gcatatctcg tatatgttct ctgaagtagc
    10081 agctatctac cccatcactc cttcttcgac tatggctgag tacgtagacg aatgggctgc
    10141 cgcaggacgt aagaacatct tcggcgaaac agtattagta caggaaatgc aatctgaagg
    10201 tggtgctgcc ggtgcagttc acggttctct tcaggctggt gcgttgacta ctacttacac
    10261 tgcttcccag ggtcttctcc tgatgatccc taacatgtac aaaattgccg gtgagttctt
    10321 gccttgcgta ttccatgtgt ctgctcgtac attggcttct cacgcattgt gtatcttcgg
    10381 tgaccaccaa gacgtaatgt cagctcgtca gactggcttt gctatgttgg ctgaaggctc
    10441 tgtacaggaa gttatggatt tggctggtgt tgctcacttg gctaccatca aatctcgcgt
    10501 tccgttcatg aacttcttcg atggtttccg tacatctcac gaaatccaaa agattgaaat
    10561 gttggaaaat gatgatcttg ctccgctgat cgaccaggaa gctttggctg aattccgtgc
    10621 ccgcgcactg aacccgatga aaccggtagc tcgtggtatg gctgaaaatc ctgaccattt
    10681 cttccaacat cgtgaatcat gcaacaacta ctatgaagca gttcctgcta tcgtagaaga
    10741 atacatgaat gaaatttcta agatcacagg tcgtaaatac ggtttgttcg attactatgg
    10801 tgcagaagat gcagaacgcg taattatcgc tatgggttct gtaacagaag ctgcccgcga
    10861 agctatcgac tacctggtag caaacggcga aaaagtgggt atggttgccg tacacctgta
    10921 tcgtccgttc tctgctaaac acttcttggc tgctgtacct aagactgcta agactatcgc
    10981 agttcttgac cgtactaaag aaccgggtgc taacggtgaa cctctttacc ttgacgttaa
    11041 agactgcttc tacggtgcag aaaatgctcc ggttatcgtt ggcggtcgct acggtttggg
    11101 ttcaaaagat actactcctg ctcaaattct ttcagtattc gaaaacttgg ctatgccaat
    11161 gccgaagaac cacttcacta tcggtatcgt agacgacgtt actttcactt ctcttcctca
    11221 aaaagaagaa atcgctttag gcggcgaagg tatgttcgaa gctaaattct acggtttggg
    11281 tgctgacggt acagtaggtg ctaacaagaa ctctgtaaag attatcggtg acaacactga
    11341 caaacactgc caggcttact tctcttatga ctctaagaag tcgggtggtt tcacttgttc
    11401 tcacttgcgt ttcggtgata atccgatccg ttctacttat ttggtaaaca ctccgaactt
    11461 cgttgcttgt cacgttcagg cttacctgca catgtacgat gtaactcgtg gtttgcgtaa
    11521 gaacggttct ttcctgctga acacaatctg ggaaggtgaa gaactggcta agaacctgcc
    11581 taacaaggtt aagaaatatt tcgcacagaa caacatttct gtatactata tcaacgcaac
    11641 acaaattgca ctggaaattg gtttgggtaa ccgtaccaac acaatccttc aatctgcatt
    11701 cttccgtatc acaggcgtta ttcctgtaga acaagctgtt gagcagatga agaaattcat
    11761 cgttaagtct tacggcaaga agggtgaaga cgttgttaac aagaactatg ctgccgttga
    11821 ccgtggtggt gaatacaaga ctttggctgt tgatcctgct tgggctaacc ttccggatga
    11881 cgcaaaagct gaaaacaacg atcctgcatt catcaacgaa gtagttcgtc cgatcaatgc
    11941 acaagacggt gacttgttgc cggtatctgc attcaagggt atcgaagacg gtacttggta
    12001 tcaaggaact gctaaatacg aaaaacgtgg tgtagctgca ttcgttcctg aatggaatgc
    12061 tgaaaactgt atccagtgta acaagtgtgc atacgtttgt cctcacgctt ctatccgtcc
    12121 gttcgtactc gacgctgaag agcagaaggg tgctaagttc gaacaactga aagctgtagg
    12181 taaagcattc gacggtatga cattccgtat ccaggtggac gttctcgact gtctgggttg
    12241 cggtaactgt gctgacatct gtccgggtaa tccgaagaag ggtggcaaag cattgacaat
    12301 gaaacacctc gaaagccaat tggctcaagc tgaaaactgg acttactgtg ctgaaaacgt
    12361 gaagactaaa caacatcttg ttgatatcaa ggctaacgtg aagaactcac agttcgctac
    12421 tccgttgttt gagttctccg gcgcttgctc tggttgtggt gaaactccat acgtgaaatt
    12481 gatttctcaa ttgttcggtg accgtgaaat ggttgctaac gctaccggat gttcttctat
    12541 ctactctggt tctgttcctt ctactccgta tactacaaac gaaaacggac acggtcctgc
    12601 ttgggctaac tcactgttcg aagacttctg tgaattcggt ttgggtatgg aactggctaa
    12661 cgaaaagatg cgtgctcgtc tcgtgaaagt gatgaacgag gctattgctg ctgattgcac
    12721 tcctgctgaa gtaaaagaac tgttcgctga atggatcaac aatatgctgg atgcggacaa
    12781 gactaaggaa ttggctgcta agatcattcc ggttgttgaa gctaacaagg ataaatgtaa
    12841 ccactgcaaa caaatcgctg aactgcaaca atatcttgta aaacgcagcc agtggatcat
    12901 tggtggtgac ggtgcttctt acgatatcgg ttatggtggt cttgaccatg taatcgcttc
    12961 cggtaaggac gttaacatcc tcgttctgga tactgaagtt tactctaaca caggtggtca
    13021 gtcttctaaa gctactccgg taggtgctat cgctaagttc gctgctgctg gtaagcgcgt
    13081 acgtaagaaa gacctcggtc tgatggctac tacttacggt tatgtatatg ttgcacagat
    13141 cgctatgggt gctgaccaag ctcaaactct gaaagctatc cgtgaagctg aagcatatcc
    13201 aggaccatct ttgattatcg cttatgctcc atgtatcaac cacggtctga aagcaggtat
    13261 gggtaagagc caggaagaag aagaaaaagc tgttaagtgc ggttactggc acttgtggcg
    13321 ttacaacccg gctttggaag aagaaggcaa gaacccattc caattggata gcaaagaacc
    13381 gaactgggaa gatttccaag gtttcttgaa gggtgaagtt cgttacgctt ctgtaatgaa
    13441 acaatatcct actgaagctg aagaactgtt caaagctgct gaagaaaacg ctaaatggcg
    13501 ttacaacagc tacaaacgtt tggctagaga aaactggggt gctgaataat agtaataccc
    13561 tataaatata aaacggtaat cttgtagaag attaccgttt ttttattgta tgaactctgt
    13621 ctaacataaa cagtactccc tttttcccac tagagttcat gtctatttta tatttaaaat
    13681 taagaatcac aatgctccaa tctatttatt ctctgacttc ggaatccaac tatccaccaa
    13741 ctgccgatgt tcatccctcc atttgcgggc tatttcttct tcatccatcc gggcatcctt
    13801 catagctgtc ataaaagagc taagttcttc tgtcgttagt ttaatgttgc caaagaattc
    13861 ggcagcaaac ggatctttct cactgaatcc tttccatgca atagcatgta tttcttccaa
    13921 gtctccatat actttcttcg gatcatccaa gaatttcaag tcaaactggt cgaacatcca
    13981 atgcggtgtc caccccgtaa tgacaatcca ttctcctttg tccatcgctt ttttcaaaga
    14041 agccagcatg gtggaactac ttgaagtcat gagggtatac ccatcaagtc cgtaagcagc
    14101 aatggcctta tcggtcgtct tcattatccc tgctcccgca tcaattccta ctatttcaga
    14161 agagaaacgg tctttattag cttccagctc actaatagac tggatcgtaa catattgagg
    14221 aacaaccagt cctacacggg cttctccata tacctccccc aaaaattcga tgctgtctcc
    14281 atactgatcc atataatctt tcatcgttat tggtaaccag gcatccagaa agacatcaga
    14341 tttctttcct gacatagata caaaaatagg ggcaagatca gcattttgca attcaacctc
    14401 atatccatgc tcttccaata ccaccttggc caaatgactc atggcaatac cttccagcca
    14461 attggcatag gctattttta ctttcttttt ctctaagcct gaattagtac aggaagctag
    14521 caaaagcata gctgacaata ctattcctac tattttatat attctcatac gtattttatc
    14581 ctttccgttt agttcttatt ttttcgtcct gccattcctt gtgtgatacg gtctaagata
    14641 atagctaaaa taacaactgc tataccacct tcaaacccaa gtccgatttt catttgggta
    14701 atacctttca atacaatttc tcccagacca ccggcagcaa tcatggcagc aatgacaacc
    14761 atagaaagcg acatcattat tgtctggttg acaccagtca ggatagtggg caacgccaaa
    14821 ggaagctgca ctttatacaa taactgccaa cgggtagctc cgaacgaacg ggaagcttcc
    14881 actacatttt taggaacttg ccgtattccc aatccggtaa ggcggaccac aggaggcata
    14941 gcaaagataa tggtggcaaa cactcccggc a
//
