LOCUS       gnlProkkaFODKBJLG_106  14880 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|FODKBJLG_106.
ACCESSION   gnlProkkaFODKBJLG_106
VERSION     gnlProkkaFODKBJLG_106
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-18 00:16:39
            Original ID  :: gnl|Prokka|FODKBJLG_106
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14880
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14880
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[9452:9806]"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      9453..9806
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..14880
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..14880
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             3..1547
                     /locus_tag="ctg106_1"
                     /transl_table=11
                     /translation="MNPVEAQDAFDARVNQSDVLLAAVPYSSIVDSTITVKESELKDLY
                     NKKKEQFKQYVETRNIKYIDVQVTASAEDRAAIQQEVTDYTNQLATANGDYTTFIRSTG
                     SEYPYVDLYYTKKAFPSDVVARMDSASIGQVYGPYYNAGDNTINSFKVLSKVAAADSVQ
                     FRQIQVYTEDAAKTKALADSIYTAIKGGADFTALAKKYGQTGESNWISSANYENAQVDG
                     DNLKFISTINNLGVNELSNVALGQGNIILQVTDKKAVKDKYKVAVIKRAVEFSKETYNK
                     AYNEFSQFIAANPTVDKVAANAEESGYKLLERNDLYSSEHGIGGIRGTKEALKWAFAAK
                     PGEVSGLYECGESDRMLVVGLVSVIEEGYRPLAQVQDQLRAEIIRDKKAEKIMADMKAA
                     NATTIAQYTSMANAVSDSVKHVTFAAPAYVAALRSSEPLVGAYASVSDINKLSAPIKGN
                     GGVFVLQVYAKDKLNETFDAQSEEATLENMHARLASRFMNDLYLKGDVKDKRYLFF"
     CDS             1725..2759
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg106_2"
                     /sec_met_domain="PF04055 (E-value: 1.1e-18, bitscore: 58.1,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPKYPLLGMTLTELQSVTKDLGMPAFAAKQIASWLYDKKVTSIDE
                     MTNLSLKHRELLKGEYDLGISAPVDEMRSVDGTVKYLYQVSDNHFVEAVYIPDEDRATL
                     CVSSQVGCKMNCKFCMTGKQGFTASLTANQILNQIAALPERDKLTNVVMMGMGEPLDNL
                     DEVLKALHILTASYGYGWSPKRITLSSVGLRKGLQRFIEESECHLAISLHSPFPSQRSE
                     LMPAERAFSIKEMVDLLKNYDFSKQRRLSFEYIVFKGVNDSLIYAKELLKLLRGLDCRV
                     NLIRFHAIPGVDLEGAGMEAMTSFRDYLTSHGLFTTIRASRGEDIFAACGMLSTAKQEE
                     SNKN"
     CDS             2834..3880
                     /locus_tag="ctg106_3"
                     /transl_table=11
                     /translation="MKKYLFYLSMALVAVVLFSCKSGKKSVFTPTSSGRAYEVLVVVEK
                     PVWERPAGRALYNVLDTDVPGLPQSERSFRIMSTSPKDFDAILKLVRNIIIVDIQDIYT
                     QPKFKYAKDVYASPQMILTIQAPDEASFEKFVEENKQPIIDFFTRAEMNRQISFLEKNH
                     NDYISTKVGSMFNSDIWLPAELSSSKTGEDFFWAGTNAATGDQNFVIYSYPYTDKDTFT
                     KEFFIHKRDSVMKANIPGAKEGMYMATDSSTVEVRPIDIHGDYTMEARGLWRIKGDFMG
                     GPFVSHTRLDKASHRIITTEVFIYSPDKMKRDLMRRLEASLYTLQLPTEKAQEQIPMGI
                     EQEEKTNK"
     CDS             3885..4982
                     /locus_tag="ctg106_4"
                     /transl_table=11
                     /translation="MEDNKIKIGITQGDINGVGYEVILKTFADPVMLELCTPVIYGSPK
                     VAAYHRKSLDLPTNFSIVNTAAEAAHNRLSVVNCTDDEVKVEFSKPDPEAGKAALGALE
                     KAIEEFREGLIDVIVTAPINKHTIQSEGFAFPGHTEYIEQRLGNGSKSLMILMKEDFRV
                     ALVTGHIPVREIASSITKELIQEKLAIFNRSLKQDFGIGAPRIAVLALNPHAGDDGLLG
                     TEEQEIISPAIQEMAAKGILCYGPYPADGFMGSGNFTHFDGVLAMYHDQGLAPFKALAM
                     DEGVNYTAGLPVIRTSPAHGTAYDIAGKGVACEDSFRQAIYVAIDVFRNRQREKEAHAN
                     PLRKQYYEKRDDSDKLKLDTVDDDI"
     CDS             5007..6233
                     /gene_functions="regulatory (smcogs) SMCOG1112:sigma-54
                     dependent trancsriptional regulator (Score: 389.6; E-value:
                     3.4e-118)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg106_5"
                     /transl_table=11
                     /translation="MTKAEIQQVKLRFGIIGNTEALTRAIDVAIQVAPTDLSVLITGES
                     GVGKESFPQIIHQYSRRKHGQYIAVNCGAIPEGTIDSELFGHEKGAFTGAIGERKGYFG
                     EADGGTIFLDEVGELPLPTQARLLRVLESGEFIKVGSSKVQKTDVRIVAATNVNLTQAI
                     AEGRFREDLYYRLNTVPIQIPPLRERGEDVLLLFRKFASDFAEKYRMPAIQLTEDAKRV
                     LLSYSWPGNVRQLKNITEQISIIETNREINAPILQSYLPAQSTQRLPALFGVKTGKSFE
                     SEREILYQVLFDMRQDVTELKKLVHEIMSERGAVTSNVGTFYTPAPVVAPTPSVPAIIH
                     PVKPNCPDDDDIQDTEEYVEESLSLDEVEKEMIRKALEKHHGKRKSAAKDLNISERTLY
                     RKIKEYGLE"
     CDS             6241..6741
                     /locus_tag="ctg106_6"
                     /transl_table=11
                     /translation="MRISLLVFTLVVGISCTVSYKFNGGNINYDKVKTISIADFPIKSD
                     YVYAPLGTKFNEDLKDIFLRQTRLKLVNNNADLEIDGEITGYNQYNQAVSADGYSSETK
                     LTITVNVRFVNNTNHEQDFEQQFSAFRVYDSRELLTAVQDGLIAEMTKEITDQIFNATV
                     ANW"
     CDS             6747..7502
                     /locus_tag="ctg106_7"
                     /transl_table=11
                     /translation="MISANLQQWIQHPETLNKDTLYELRTLVTRYPYFQSLRLLYLKNL
                     YLLHDISFGAELRKAILHVADRRKLFYLIEGERYILKPRKKNALPETEVLEEEPSLDRT
                     LSLIDAFLATVPEEVSAQTSLDYATDYTTYLLQEDDTPELEETPKLRGHELIDGFIERS
                     EEETSIRLQPADENKAISEEEESETHHEEDEDDSCFTETLAKIYVKQHRYSKALEIIKK
                     LSLKYPKKNAYFADQIRFLEKLIINAKSK"
     CDS             7507..7887
                     /locus_tag="ctg106_8"
                     /transl_table=11
                     /translation="MYLLLVILMVIAAILMCFIVLIQNSKGGGLASGFSSSNQIMGVRK
                     TTDFLEKATWGLAAFMVVMSIATAYVVPTSSSKTQDVIMEQAQQEEQTNPYNLPVGTTA
                     PKTDAAAPVEAPATETPATPAN"
     CDS             8058..9446
                     /gene_functions="transport (smcogs) SMCOG1106:major
                     facilitator transporter (Score: 97.1; E-value: 1.4e-29)"
                     /gene_kind="transport"
                     /locus_tag="ctg106_9"
                     /transl_table=11
                     /translation="MTEQLKNKLSDSKTLRWSVLALVAFTMLCGYFLTDVMSPLKPMLE
                     KELLWDSLDYGFFTSAYGWFNVFLLMLIFGGIILDKMGVRFTGMGACILMVLGCGLKYY
                     AISTTFPEGALIMGFKTQVFLAALGYAIFGVGVEIAGITVSKIIVKWFKGKEMALAMGL
                     EMATARIGTTLAMVLTVPIADYFGYTDESGSFHTNIPMPILLCLIMLCIGTIAFFIYTF
                     YDKKLDASLDAQGEEPEEPFRMKDVMLIVTNKGFWLIALLCVLFYSAVFPFIKYATDLM
                     VQKYNVDPKLAGNIPGLLPIGTIFLTPLFGTLYDRIGKGATLMIIGAVMLIGVHTLFAL
                     PILNVWWFATVIMIVLGIAFSLVPSAMWPSVPKIIPEKQLGTAYALIFWVQNWGLMGVP
                     LLIGWVLNTYCKGPVVDGAQTYDYTLPMAIFACFGVLALIVALMLKAEDKKKGYGLQEA
                     NIKK"
     CDS             9453..9806
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg106_10"
                     /sec_met_domain="PF05402 (E-value: 2.1e-17, bitscore: 53.2,
                     seeds: 461, tool: rule-based-clusters)"
                     /sec_met_domain="PqqD_RRE (E-value: 2.9e-10, bitscore:
                     29.8, seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MADVKEKINLLDVIPFRSENITAEKGSDGTVTIAFPRFKYEWMRR
                     FLLPKGMSADIHVRLEDHGTAVWELIDGKRTVRRIIEELAEHFNYEENYESRITAYITQ
                     LQKDGFVKLVIEN"
     CDS             complement(9940..10995)
                     /locus_tag="ctg106_11"
                     /transl_table=11
                     /translation="MKKLIILTGLLLSTSAYAQTEVTAGVTRGKDYGVTYALPKTAINI
                     EVKVNKVTYTPGEFSKYADRYLRLTDVSGEPQEYWELVSVKAKSVGIPDSEHTYFVKLK
                     DKTVAPLIELTEDGIVKSINVPLSPKKSAPMQPATTQKKKINPRDFLTEEILMAGSTAK
                     MAELVAKEIYNIRESKNALVRGQADNMPKDGEQLKIMLANLEEQEAAMTEMFSGTLNKD
                     EKIFNIRLTPDKEMDNEVAFRFSKKLGIVANNDLAGEPVYITLKNLKTVNVPEDDGKKK
                     VDGIAYNVPGKAQVTLTEGKKQWFNGELPVTQFGTIEYLAPALFNKKSTVQVTFNPDTG
                     GLIKVDREEGE"
     CDS             complement(11068..12579)
                     /locus_tag="ctg106_12"
                     /transl_table=11
                     /translation="MKIFPSSSIKKLDAYTIEHEPIASIDLMERAAQALTKAITERWDI
                     TTPVTVFAGPGNNGGDALAVARMLAEKEYKVEAYLFNPKGELSADCQTNKELVEMMDNV
                     KFSEVSTQFVPPALTMDHLVVDGLFGSGLNKPLSGGFAAVVKYINASPATVVAIDIPSG
                     LMGEENTFNVKANIIRAQLTLSLQLPKLAFLFAENSEFVGEWKLLDINLSREAIEETES
                     NYALLEAEEIHALIKPRNTFSHKGNFGHALLIAGSYGMAGASILAARACMRSGVGLLTV
                     HAPIRNNDILQISVPEAIIESDASDTYFACPTDTDDYQAVGIGPGIGRSEETEAALLEQ
                     LSGCQTPLVLDADALNILANHRHALTTLPKGSILTPHPKELERMVGKCQNSYERLMKAC
                     ELARTAKVHIILKGAYSAIITPSGKCYFNSTGNPGMATAGSGDVLTGVVLALLAQGYPA
                     EEAAKIGTYVHGLAGDFARKKQGVISMTAGDIISNLPLAWRLVSE"
     CDS             complement(12623..13963)
                     /locus_tag="ctg106_13"
                     /transl_table=11
                     /translation="MNNVQQVKTYSQRKISDFLFILWAGGAALLSYSLVYALRKPYTAA
                     GFDGLEAFGMDYKVVVTIAQILGYVLSKFIGIKLISELKRENRMKFILISIILAEASLI
                     LFGLLPAPYNIGAMFLNGLSLGCMWGIIFSFIEGRRMTDILASLLGVSMVISSGTAKSA
                     GLYVMDTLNISEFWMPALIGGVALPLLALLGYALNRLPQPTAEDIAMKSKRETLNGKQR
                     WELFKNFMPFLTLLFIANVVLTILRDIKEDFLVKIIDVSQYSSWMFAQVDSVVTLIILI
                     IFGLMVFVRSNLKALSILLGLIIASMVVMAVVSFGYEQLQLNAIAWLFIQSLCLYLAFL
                     TFQTIFFDRFIACFKIRGNVGFFIAMNDFLGYTGTVIVLAVKEFFSPDINWTAFYNLMA
                     GYVGIICFVAFVCSFIYLHQRYRRENYGKTGVFRKKEEEKEVPDFVY"
     CDS             14269..14865
                     /NRPS_PKS="Domain: oMT (50-151). E-value: 8.8e-15. Score:
                     45.5. Matches aSDomain: nrpspksdomains_ctg106_14_oMT.1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089:methyltransferase (Score: 100.2; E-value:
                     2.3e-30)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg106_14"
                     /transl_table=11
                     /translation="MNKRGFVSKILQNFRKPEGFFGRMILWGMNTGHASLAQWGMSCLQ
                     WQPEWSVLDIGCGGGANLLQILQRCPQGKAYGIDISPESVTFARKKNKKYLGTRCFIEQ
                     GGVHRLPYPDYAFDAVTAFETVYFWGNLQHAFTEVVRVLKPGGSFLICCEISDPANKAW
                     TGLVEGMEIHSCDELKAILSKSGFTDTTIFRTKKE"
     aSDomain        14419..14721
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg106_14_oMT.1"
                     /domain_subtypes="oMT"
                     /evalue="8.80E-15"
                     /label="ctg106_14_oMT.1"
                     /locus_tag="ctg106_14"
                     /protein_end="151"
                     /protein_start="50"
                     /score="45.5"
                     /tool="antismash"
                     /translation="SVLDIGCGGGANLLQILQRCPQGKAYGIDISPESVTFARKKNKKY
                     LGTRCFIEQGGVHRLPYPDYAFDAVTAFETVYFWGNLQHAFTEVVRVLKPGGSFLI"
ORIGIN
        1 tctctaatcc ggttgaagca caggatgcat tcgacgcaag agtaaaccag tcggatgttc
       61 tgttggctgc tgttccttat tcttctattg tagactctac tatcacagtg aaagagtctg
      121 aactgaaaga tctctataac aagaagaaag aacagttcaa acaatatgtt gaaacacgca
      181 acatcaaata catcgatgta caggtgacag ccagtgcaga agacagagct gctatccagc
      241 aagaagtgac tgattataca aaccaattgg ctactgccaa tggtgattat actactttca
      301 tccgttctac cggatcggaa tatccgtatg ttgatttgta ctataccaag aaagctttcc
      361 cgtcagatgt agttgcacgc atggattcag cttcgattgg acaagtatat ggcccttact
      421 acaatgcagg cgacaatact atcaattcgt tcaaggtgtt gtctaaagtg gctgctgccg
      481 attctgtaca gttccgtcag attcaggttt acacagaaga cgctgctaaa acaaaggctt
      541 tggctgacag catctatact gctattaagg gtggagccga ctttacagct ttggctaaga
      601 agtacggaca aacaggtgaa tccaactgga tttcgtctgc taactacgaa aatgcacagg
      661 ttgatggcga taacttgaaa tttatcagca ctatcaacaa tctgggagta aacgaactct
      721 ctaacgtagc attgggacaa ggcaatatca ttttgcaggt gactgataag aaagctgtga
      781 aagataaata taaagttgcc gttatcaagc gtgcggttga gttcagcaaa gaaacttata
      841 ataaagctta taatgaattc agccagttta ttgcagctaa cccgacagta gacaaggttg
      901 cggccaatgc tgaagaatca ggctataaat tgctcgaaag aaatgatctg tatagctcag
      961 aacacggaat cggtggtatc agagggacta aagaagcact gaaatgggcc tttgctgcaa
     1021 aaccgggtga agtttccggc ttatatgaat gtggcgaaag cgaccgcatg ttggttgttg
     1081 gtctggttag cgtgatcgaa gaaggttatc gtcctttggc ccaggttcag gatcagttga
     1141 gagctgaaat cattcgtgat aagaaagctg agaagatcat ggccgatatg aaggctgcca
     1201 atgcaactac aattgcccag tacacatcga tggccaatgc agtaagtgat tctgtaaaac
     1261 acgtaacatt tgcagcgcct gcttatgtag ccgctttgcg tagtagtgag ccgctggtag
     1321 gcgcatacgc ttcggtttcg gatatcaata agctgagcgc tcctatcaag ggtaatggcg
     1381 gtgtgtttgt gttgcaggta tatgccaaag ataagctgaa cgaaacattc gatgcccaat
     1441 cagaagaggc tacattggaa aacatgcatg cccgtctggc aagtcgtttt atgaacgatc
     1501 tttatctgaa aggcgatgta aaagataaac gatacctgtt cttctaaaaa cggatttgtt
     1561 tttttagata acgtcgcttt aatatacgaa aggctgttcc gcacggaaca gcctttcttt
     1621 ttgctatctc tttccctctt cccattaact tttgtccctt ctctttttta aaatcgactt
     1681 ttattcctta catttgcatg aataaataaa tatttgtagt aaatatgccc aaatatccgc
     1741 ttttaggaat gacccttacc gaattgcaat ctgtcaccaa agatttgggg atgcctgctt
     1801 ttgcagccaa acagatcgct tcctggttat acgataaaaa agtgacttct attgatgaaa
     1861 tgaccaatct gtcgttgaag catagagagt tgctcaaggg agagtatgat ttggggatat
     1921 ccgcgcctgt tgatgagatg cgttccgtag atggtacggt gaagtatctt tatcaggtga
     1981 gtgacaatca ttttgttgaa gcggtgtata ttccggacga ggatcgggcg acattgtgcg
     2041 tgtcttctca ggtaggctgt aaaatgaact gtaagttctg catgacgggt aaacaaggat
     2101 ttaccgcaag tctgacagcc aatcagatct tgaatcaaat cgcagcattg ccagagcggg
     2161 ataagttgac taatgtcgtg atgatgggga tgggcgagcc tctcgataat ttggatgaag
     2221 tattaaaagc actgcatatc ctgaccgctt cgtatggata cggatggagc cccaagcgta
     2281 ttactttgtc gtctgtagga ttgcggaaag gacttcaacg ctttattgaa gaaagcgaat
     2341 gtcatctggc tatcagcctg cattctcctt ttccttcaca acgttctgag ctgatgccgg
     2401 ccgaaagggc tttctcgatt aaagaaatgg tcgatctgtt aaaaaactat gattttagta
     2461 aacagcgcag actttcgttt gaatacattg tttttaaggg cgtcaatgat tcgctgattt
     2521 atgctaagga gctgttgaaa ttgctgcgtg ggcttgactg ccgggtgaac ttaatccggt
     2581 ttcatgccat tcctggggta gacctcgagg gtgccggtat ggaggctatg acgtcatttc
     2641 gggactacct gacctcacat ggactgttca ctaccattcg agcttcccgg ggagaagata
     2701 tttttgccgc ttgcgggatg ttatcgacgg ctaaacagga ggagagtaac aagaattaat
     2761 ataaattatc agcacattgg atgaaagtat acgaccattt cgtagatttg tgaaaacatt
     2821 aaaattgatg catatgaaaa agtacctgtt ttacctcagt atggctcttg tagcagtagt
     2881 gttgttttct tgtaaaagcg gcaagaagag tgtgtttact ccaacttcca gcggacgtgc
     2941 ttatgaagtc ctcgttgtgg ttgagaagcc tgtgtgggag cgtcctgccg gtagagcttt
     3001 gtacaatgtg cttgatacag atgtgcccgg acttccgcaa tcggaacgtt cgttcaggat
     3061 catgtctact tctcccaaag attttgatgc catcctgaag ttggtgcgca acattattat
     3121 cgtagatata caggacattt atacccaacc taaattcaag tatgccaagg atgtatatgc
     3181 atctccccag atgattttga ctattcaggc tccggacgag gcatcatttg agaagtttgt
     3241 cgaagagaac aaacagccga ttatagactt ctttacccgt gccgaaatga accgtcagat
     3301 ctctttcctg gagaaaaatc ataatgacta tatttcgacg aaagtaggta gcatgttcaa
     3361 cagtgatatc tggcttccgg ccgaactgag cagttcgaag acaggagaag actttttctg
     3421 ggcaggtact aatgccgcta ccggagacca gaactttgta atctactctt acccgtatac
     3481 agataaggat acctttacga aagagttctt tatccataag cgcgattcag tgatgaaggc
     3541 taatattccg ggtgccaaag agggtatgta catggcgact gattcgtcta ccgtagaggt
     3601 tcgtccgatt gatattcatg gagattacac aatggaagca cgcggactgt ggcgcataaa
     3661 gggcgatttc atgggtggcc cgtttgtttc gcacacccgt ctggataaag ccagccaccg
     3721 tattatcact acagaagtat ttatttactc acccgataaa atgaaacgtg acctgatgcg
     3781 ccgattggaa gcatctctgt atactttgca acttcctacc gagaaggcgc aggaacagat
     3841 tccgatgggc atagagcagg aggagaaaac taacaaataa caaaatggaa gataacaaaa
     3901 taaaaattgg catcactcag ggagacataa atggggtagg atacgaagtc attttaaaaa
     3961 cgtttgccga ccccgtcatg ttggaactct gtacaccggt catttacggc tctccgaaag
     4021 tggctgcata tcaccgcaag tcgcttgatt tgcctactaa cttcagtatt gtcaataccg
     4081 ctgcagaagc tgcccacaat cgcctgagcg tggtcaactg tacggatgac gaggtgaaag
     4141 tagagttctc aaaacccgat ccggaagccg gtaaagcagc tttgggagca cttgagaagg
     4201 cgatagagga gttcagggaa ggcttgatcg atgtcatagt gacggctcct atcaataagc
     4261 atacgattca gtccgaagga tttgcttttc ccggacatac ggaatacatc gaacaacgtc
     4321 tggggaatgg ttcaaaatca ctgatgatcc tgatgaaaga ggatttccgg gtagctttgg
     4381 taacaggaca tattccggtt cgcgagatag cctcttcaat aaccaaggaa ctgattcagg
     4441 agaaacttgc catattcaac cggtcgttga aacaggattt cgggattggt gcaccgcgca
     4501 tcgcagtgtt ggcactgaat ccgcatgccg gagacgacgg attgctcggt acagaagaac
     4561 aggaaatcat ttctcctgct attcaagaaa tggctgccaa gggaatcttg tgctatggcc
     4621 cttatccggc tgacggattt atgggatcgg gcaatttcac ccattttgac ggagtactgg
     4681 ccatgtatca cgatcaggga ttggctcctt tcaaggcatt ggccatggat gaaggtgtga
     4741 actacacggc gggtttgccg gtgatacgca cttctcccgc gcatggcaca gcctatgata
     4801 ttgcaggaaa aggcgttgct tgcgaagatt cattccgtca ggctatttat gtagcgatcg
     4861 acgtattccg taaccgtcaa cgtgagaagg aagcacatgc caatccgtta cgtaaacagt
     4921 attacgagaa acgagacgac agtgataaac tgaagctcga tacagtagat gatgatattt
     4981 aatcaggaag ggagtttagt gcgaatatga caaaagcgga aatacaacag gtaaaactaa
     5041 ggttcggtat tattggtaac actgaagctt tgacgcgtgc gatagatgtt gccatacagg
     5101 tggcacctac cgatttgtcc gtgctaataa ccggagagag tggtgttggt aaggaaagtt
     5161 tccctcagat cattcaccaa tacagtcgcc gaaagcatgg acagtatatt gctgtcaact
     5221 gtggtgctat tcctgaagga accatcgatt cggaactgtt cggtcatgaa aaaggggctt
     5281 ttacgggagc catcggtgag cgaaagggct attttggtga agccgacggc ggaactattt
     5341 ttctggatga agtcggagaa ttgcctttgc ccacgcaggc acgtttgctt cgtgtactcg
     5401 agagtgggga gtttataaaa gtaggctcct ccaaagtaca gaaaacggat gtccgcattg
     5461 tggctgctac caatgtcaat ttgacccagg ccattgcaga gggacgtttc cgtgaggatt
     5521 tatactatcg tctcaatacg gtgcccatcc agatccctcc tttgcgggag cgtggagaag
     5581 atgtgctgtt actgttccgt aagtttgcaa gtgactttgc agagaagtat cgtatgcccg
     5641 ccatacagct gaccgaagat gccaaacggg ttttgctgtc ttattcctgg ccgggtaatg
     5701 tgcgtcagtt gaagaatatc acggagcaaa tctctataat tgagaccaat cgtgagatta
     5761 atgcccctat cttgcaatct tatctgcctg cccagagtac gcagcgattg cctgccctgt
     5821 ttggtgtaaa gacagggaag agcttcgaaa gtgaacgtga aatcttatat caggtccttt
     5881 ttgacatgcg acaagatgtg accgaactga aaaagcttgt acacgaaatc atgtccgagc
     5941 gcggagcggt aacctccaat gtcggtacgt tttatacgcc ggctccggta gtagccccta
     6001 caccctcagt gcctgccatc attcatccgg tcaagcccaa ttgtcccgat gacgatgaca
     6061 tacaagatac cgaagagtat gtggaagagt cgctttcgtt ggacgaagtc gagaaagaaa
     6121 tgatacgcaa agcccttgaa aagcatcatg gcaagcgaaa aagtgcggca aaggatctta
     6181 atatatccga gcgtaccctt taccgaaaaa taaaagaata tggattggaa taaaaagata
     6241 atgcgaattt cactgctggt tttcacactg gtagtaggaa tttcgtgtac tgtttcttat
     6301 aagtttaatg gtggtaatat caattacgat aaggtaaaga ctatctctat tgccgacttt
     6361 cctattaagt cggactatgt ttatgcaccg ttaggcacta agttcaacga ggacctgaaa
     6421 gacattttcc ttcgtcagac ccgtctgaaa ctggtgaata ataatgccga cctcgagatt
     6481 gatggagaga ttaccggata caaccagtat aaccaggctg tttcggccga cggatactct
     6541 tctgaaacca agctgaccat cacagtgaat gttcgttttg tgaacaatac gaatcatgaa
     6601 caggacttcg agcaacagtt ctcggctttc cgtgtttatg attcgaggga gttgctgaca
     6661 gccgttcagg acggactgat tgcggagatg accaaagaga ttacagatca aatatttaac
     6721 gcaacagtag caaactggta attagaatga tttctgctaa cttacaacaa tggattcagc
     6781 atccggaaac gctgaataaa gatactttgt acgagttgcg aacgcttgtc acacgctatc
     6841 cttattttca gtcactgcga ttactctatc ttaaaaatct atatttgttg cacgatatct
     6901 ctttcggcgc cgagcttcgt aaagccatat tgcatgtggc tgatcgccgg aagctgtttt
     6961 atctgattga gggtgaacga tatattttga aacctcggaa aaagaacgca cttcccgaaa
     7021 cagaagtttt agaggaagag cccagcctcg atcgtacgct ttccctgatc gatgcttttc
     7081 tggccaccgt gcccgaagag gtttcagccc agacaagcct ggactatgca acagactata
     7141 ccacctattt gctgcaagaa gacgatacac cggaactgga agaaactccc aaacttcgcg
     7201 gtcatgaatt gattgacggc tttatcgaaa gaagtgaaga agaaacatcc atccgtttgc
     7261 aaccggcaga tgaaaataaa gctatctccg aagaggaaga gagcgagacg catcatgaag
     7321 aagatgaaga tgatagctgt ttcaccgaaa cattggccaa aatatacgtc aaacagcatc
     7381 gatattccaa ggcacttgaa attattaaaa aattaagttt gaaatatcca aaaaaaaatg
     7441 cttactttgc agaccaaatc agatttttag agaaattgat tattaacgct aaatcaaaat
     7501 aacaaaatgt acttattatt agttatctta atggttattg cagccatact gatgtgcttc
     7561 attgtgttga ttcagaactc aaaaggcggt ggtcttgctt cagggttctc atcatctaac
     7621 cagattatgg gtgtacgcaa aactacagac tttctggaaa aagcaacttg gggcttagct
     7681 gcatttatgg ttgtgatgag cattgctact gcgtatgtcg ttccgacttc ttcttctaaa
     7741 acacaagatg tcattatgga acaggcacag caggaagagc agaccaaccc ttataacctg
     7801 cccgtaggta ctactgcacc gaagacagac gctgctgctc cggttgaagc acctgccaca
     7861 gaaactccgg ctactccggc aaactaacaa cagattcttt ttaagaaacg ataagcgaag
     7921 ctgcaatttc aaaccgaaac ttgcagcttc gcttattttt tgccgtaaaa tgcatctttt
     7981 tgttaggcat acaaggcaga tttagttacc tttgttcgca ataacacttt tactaatttc
     8041 tgagtttaaa tattacaatg acagaacaat tgaaaaacaa attgagtgac tccaaaacac
     8101 ttcgttggag tgtgctcgct ctggtcgcgt ttactatgct ttgcggctat ttcctcaccg
     8161 atgtaatgtc ccctttaaag cctatgctcg agaaagagct tctctgggat agtttggact
     8221 acggattctt taccagtgct tacggatggt tcaatgtatt cctgctcatg ttgattttcg
     8281 gtggtattat tctcgataag atgggagttc gtttcaccgg tatgggagct tgtatactga
     8341 tggtgttggg ttgtggacta aaatattatg ctatctctac tacttttcct gagggagctt
     8401 tgattatggg tttcaagact caggtctttc tggcggcttt aggatacgct atctttggtg
     8461 tcggcgtaga gatcgccggt atcactgtct ctaagattat cgtgaaatgg tttaaaggta
     8521 aagagatggc tttggctatg ggacttgaga tggcaaccgc acgtatcggt accactttgg
     8581 ctatggtgct taccgttccc attgccgatt atttcggcta tacggatgaa agcggcagtt
     8641 tccataccaa tattccgatg cctattttgt tgtgcctgat catgctgtgc atcggtacta
     8701 tcgccttttt catttatacc ttttatgata agaaacttga cgcttcttta gatgctcagg
     8761 gagaagaacc ggaagaaccg ttccgtatga aggacgttat gctgattgtc accaataaag
     8821 gcttctggct gattgcttta ttgtgtgtac tattctattc tgctgttttc ccctttatta
     8881 aatatgcaac cgacttgatg gtgcagaagt ataacgtaga ccctaagctg gccggaaata
     8941 ttccgggatt actaccgata ggtaccatct tcctgactcc gttgtttggt actctttatg
     9001 accgtatcgg taagggagcg acgttgatga ttatcggtgc cgtcatgctg attggtgtgc
     9061 atactttgtt tgcgcttccc attctgaacg tatggtggtt tgccactgtg attatgattg
     9121 ttctgggtat tgctttttca ctggtgcctt cggccatgtg gccttctgtt ccgaaaatta
     9181 ttccggagaa acaactgggt actgcctatg ctttgatttt ctgggtgcag aactggggat
     9241 tgatgggggt acctctgttg atcggatggg tgttgaatac ctattgcaaa ggtcctgttg
     9301 tggatggagc gcagacttat gactatactt tgcctatggc tatctttgct tgtttcggtg
     9361 ttttggctct gattgtagct ttaatgttga aagcggaaga caagaagaag ggatacggac
     9421 tgcaggaagc aaatatcaaa aaataacagt atatggcaga cgtgaaagag aaaataaatc
     9481 ttctggatgt aattcctttc cgtagtgaaa atattacggc cgaaaaggga agcgatggta
     9541 ccgttaccat tgctttcccc cggtttaaat acgagtggat gcggcgattc ttgttgccta
     9601 aaggaatgtc tgcggatatt catgtccggc tggaagatca tggcactgcc gtatgggagt
     9661 tgattgacgg aaagagaacc gtacgccgga ttattgaaga gctggcagaa cacttcaatt
     9721 atgaagaaaa ttacgaatca cgtattacgg cttatatcac tcagttgcag aaagacggat
     9781 ttgtgaaatt agtgattgag aactgattgc attacgatat actatcggaa tataataaag
     9841 agactccggc tgatttaaaa atgaagtgca ccctaaaagt taaacatgaa cttttggggt
     9901 gcacttcatt taagatcggc cggagttttt gattatgttt tattctcctt cttctctatc
     9961 taccttgatc aagcctcctg tatccgggtt gaaagtaacc tgaacagtcg atttcttatt
    10021 gaaaagcgcc ggagccagat attcgatggt accgaattgt gtgacaggaa gttctccgtt
    10081 aaaccattgc tttttcccct ccgttagtgt tacttgtgct ttgccgggca cattataggc
    10141 aatgccgtcc accttctttt tgccatcgtc ttccggtacg ttgacggttt tcagattctt
    10201 cagcgtgata taaaccggct ctcctgcaag atcgttattg gcaactatgc ccagcttctt
    10261 cgaaaagcgg aaagctactt cgttgtccat ttccttatcc ggagtgaggc ggatgttgaa
    10321 tatcttttcg tctttattca aggtacccga gaacatttcg gtcatggcag cctcttgctc
    10381 ttccaggttg gcgagcataa tcttcagttg ctccccatct ttgggcatgt tgtctgcctg
    10441 tccgcgtacc agggcatttt tactttcacg aatgttataa atctctttgg caaccaactc
    10501 cgccatttta gccgtagaac ctgccatcag aatctcttcg gtcagaaaat cacgtggatt
    10561 tatcttcttt ttctgtgtcg tggcgggttg catcggagcc gattttttag gagatagcgg
    10621 tacgttgatt gattttacga taccatcttc ggtcaattct attagcggag ctactgtttt
    10681 atctttcagc ttgacaaaat aggtatgttc gctatcgggg ataccgacag attttgcttt
    10741 gacgctgacc agttcccaat attcctgagg ctcacccgac acatcggtca accggagata
    10801 acggtcggca tacttgctga attctcccgg agtatatgtc actttattga ctttgacttc
    10861 aatattgatt gctgttttag gaagtgcata ggttacaccg taatcttttc cccgggtaac
    10921 tcccgctgta acttcggtct gggcataagc cgaggtagag agtaacagcc ctgtcagtat
    10981 aattagcttt ttcatttccg gtttatttta actggtttaa aaaacaaagt taatgaagtt
    11041 atttggaaaa tcataagttg ttaactttta ttcgcttacc agacgccaag ccaatggcag
    11101 attactgata atgtctcctg ccgtcatgct gataacgcct tgctttttgc gtgcgaaatc
    11161 acctgccaga ccatgtacat aagtaccgat tttggcagct tcttcagccg gatatccctg
    11221 tgcgagcaaa gccagcacga cacctgtcaa tacatctccg cttccggctg ttgccatacc
    11281 cggattaccc gtagagttga aatagcactt gcccgagggg gtgataattg ccgaataggc
    11341 tccttttaat atgatatgta ctttggcggt tcgggccagt tcacaggcct tcatcagtcg
    11401 ttcgtatgag ttctggcatt tgcccaccat gcgttccagt tctttgggat ggggagtcag
    11461 aatagagcct ttgggcaatg tggtcagtgc gtggcggtgg ttggccaata tgtttagtgc
    11521 atcggcatcc agtaccagag gtgtctggca gccactgagt tgttcaagca gtgcagcttc
    11581 ggtctcttcc gagcgtccga tgcccggacc gattcctaca gcctgatagt catccgtatc
    11641 tgtagggcag gcaaagtagg tatcgctggc atccgattcg ataattgcct ccggaaccga
    11701 aatctgcagg atatcattgt tgcgtatagg tgcatggact gtcagtaagc ctacacccga
    11761 acgcatacag gcgcgggctg ccagtatcga cgcgcctgcc atgccgtacg aaccggcaat
    11821 cagcagagca tgcccaaagt ttcctttgtg tgagaaagtg ttacggggtt tgatcagagc
    11881 gtgtatttct tccgcttcca ataaggcata attgctttcc gtctcttcaa tcgcttcacg
    11941 actgaggttg atatccaaca gtttccattc gcctacgaat tcggaatttt cagcaaagag
    12001 gaaagccagt ttcggcaatt gcaggctcaa tgtcaattgg gcacggatga tattggcttt
    12061 tacattaaat gtgttctctt ctcccatcag tcccgagggg atatcgatgg cgactacggt
    12121 ggcaggcgat gcattgatat atttcactac tgccgcaaaa ccgccactta gcggcttatt
    12181 aagtcccgaa ccaaaaagtc cgtccactac cagatgatcc atcgttaggg caggaggtac
    12241 aaactgtgtg cttacttcgc tgaacttcac attatccatc atctctacca gctccttgtt
    12301 ggtctggcag tcggcagaca gttccccttt cgggttaaac agataggctt cgaccttgta
    12361 ttccttttcc gccaacattc gggctacggc aagggcatct ccgccattgt tgcccggtcc
    12421 ggcaaatacc gtgacgggag ttgtgatgtc ccagcgttcg gtgatggctt tggtcagtgc
    12481 ctgtgcggcc cgctccatca ggtcgatcga tgcaatcggt tcatgttcta tggtgtaagc
    12541 atccagtttc ttgatgctgc tacttggaaa aatcttcatg gtgaactttc attttaagtt
    12601 ttttgaccca caaagatagc aattaatata cgaaatcggg aacttctttt tcttcttctt
    12661 tttttctgaa tacccctgtc tttccgtaat tctccctgcg gtagcgttgg tgcaggtaga
    12721 tgaaagagca tacaaaagca acgaaacaga ttattcccac atatcctgcc atcagattgt
    12781 agaaagctgt ccagttaatg tccggtgaaa agaattcttt gacagccaat actatgactg
    12841 ttcccgtata gcccagaaaa tcattcatag caatgaagaa acccacgtta cctcgaattt
    12901 tgaagcaagc gataaaacgg tcgaagaaga tagtctggaa agtgagaaaa gccagataga
    12961 gacacaggct ctggatgaat agccaggcga tggcgttcag ctgcaattgt tcgtaaccaa
    13021 acgaaacgac tgccatcact accatgctgg caatgatcaa tcccagtaat atcgacagtg
    13081 ctttcaagtt gcttctgacg aacaccatta atccgaaaat tatcagaata atgagggtta
    13141 ctacgctgtc tacctgtgca aacatccacg aagagtattg agagacatcg ataattttta
    13201 ccaggaagtc ctcctttata tctctcaaga tagtcagtac cacattggct ataaagagca
    13261 gagtgaggaa aggcatgaaa ttcttaaata gctcccatcg ttgcttgccg ttcagtgttt
    13321 cccgtttcga tttcatggca atgtcttcgg ctgttggctg tggaagccgg ttgagtgcat
    13381 atcccaacaa ggcaagtaaa ggaagggcaa ctccgcctat cagggcaggc atccagaatt
    13441 cgctgatgtt caaagtgtcc atgacataca aaccggccga cttggcggta cccgagctga
    13501 tgaccatact gactccgagc aagctggcaa gaatgtccgt cattcgtctt ccctcgataa
    13561 agctaaaaat gattccccac atacatccca gtgaaagtcc gttcagaaac atggctccta
    13621 tattataagg tgcgggcaac agtccgaaca atattaacga agcttcagcc agaattatgg
    13681 agatcagaat aaacttcatc cggttttctc gttttaattc ggagattaat ttaattccga
    13741 tgaatttaga aagtacatat cctaatattt gtgcgatggt aactaccact ttgtagtcca
    13801 ttccaaacgc ttcaagtccg tcaaatccgg ctgctgtgta aggctttctc agtgcatata
    13861 ccaatgaata ggagagcagc gctgctccgc ctgcccaaag aatgaaaagg aaatcagaaa
    13921 tttttctctg cgaataagtt tttacttgct gtacattgtt cataacatct gcttgttgtt
    13981 ttccggtgca aaaataggag ggtagtgtta cagacctgtt actgaatata tgaatgttta
    14041 ttattaatag atattgataa tgaatctgtt atgttgtaat gtttatgtaa tatttatgaa
    14101 acggaaacga aaagagcatc gcacctccgg gcatctgttc gtcataattt taacgggaag
    14161 cagatgcata cctgcaaata tattttagga aataaattcc ctatttctgg gtattgcctg
    14221 tttgggcaga aactgtactt ttgcctgaaa tattaaatca gcagacaaat gaataagaga
    14281 ggctttgtaa gcaagatctt acagaatttc cggaagcctg aaggtttttt cggaagaatg
    14341 atactttggg ggatgaatac aggacatgca tcattggcgc aatggggaat gtcatgtttg
    14401 caatggcaac cggaatggag tgtactcgac atcggttgcg gtggtggtgc caatttgcta
    14461 cagatattgc aacgttgccc gcaagggaaa gcgtatggca tagatatttc accggagagt
    14521 gtcacctttg cgcgtaaaaa aaataaaaag tatctcggta cacgctgctt tatcgagcag
    14581 ggaggagtcc accgacttcc ctatcctgat tatgcgttcg atgcggtcac tgctttcgag
    14641 actgtctact tctggggtaa cctgcagcat gcttttacgg aagtggtgcg tgtgttaaag
    14701 cccggtggat cgtttcttat ctgttgtgag ataagcgatc ctgccaataa ggcttggacg
    14761 ggacttgttg aagggatgga gattcattcc tgtgatgaac tgaaggcgat tctttccaaa
    14821 agtggtttta ccgatacgac catattccgg acgaagaaag aataactgtg cctggtaagc
//
