LOCUS       c00018_gnlPro..        14517 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|OBHCOKAE_18.
ACCESSION   c00018_gnlPro..
VERSION     c00018_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-07 05:48:51
            Original ID  :: gnl|Prokka|OBHCOKAE_18
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 7745
            Orig. end    :: 22262
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14517
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[17745:22137]"
                     /cutoff="10000"
                     /detection_rule="(minimum(2, [Aminotran_5, GCV_H, GCV_T,
                     GDC-P, SoxG]) and GCV_H and GCV_T_C)"
                     /neighbourhood="10000"
                     /product="Glycine_cleavage"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..14392
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(2, [Aminotran_5, GCV_H, GCV_T,
                     GDC-P, SoxG]) and GCV_H and GCV_T_C)"
                     /neighbourhood="10000"
                     /product="Glycine_cleavage"
                     /protocluster_number="1"
     cand_cluster    1..14517
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(2, [Aminotran_5, GCV_H, GCV_T,
                     GDC-P, SoxG]) and GCV_H and GCV_T_C)"
                     /kind="single"
                     /product="Glycine_cleavage"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14517
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Glycine_cleavage"
                     /region_number="1"
                     /rules="(minimum(2, [Aminotran_5, GCV_H, GCV_T, GDC-P,
                     SoxG]) and GCV_H and GCV_T_C)"
                     /tool="gutsmash"
     CDS             143..241
                     /locus_tag="ctg18_12"
                     /transl_table=11
                     /translation="MERKMLFPPLLRKVKHFRHKSKEFSLDKSASH"
     CDS             complement(227..994)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HAD"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg18_13"
                     /sec_met_domain="HAD (E-value: 4.3e-36, bitscore: 115.8,
                     seeds: 107, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDDWKKRGAALFDMDGTLLPWDTQYIFSCFVVRRHPWRRLLIFL
                     FLACIPLYILRIWDENRMKRAYLMYLWGLPAETVREYGRKFAEMAQEWIYPELKERLAG
                     YRKKGYLCLMVSASPSFYVKPLGELLGFDEVLGTDVLLEERMPAMPELPNGNNKGAVKV
                     ERLRERNVLPEHGVLENAVAYSDSAADLPMLLSCRRRVLVNPSPALKEDRLLDGAECLY
                     PARPWKGRFGKIWRIGFFVMGLVDVNNVKSMTC"
     CDS             complement(1127..1375)
                     /locus_tag="ctg18_14"
                     /transl_table=11
                     /translation="VNGKKTNIASYSCRPGDVIAVGGKASSQQLVTRSLDLTQATVVPD
                     WLECDRDKLTGKIARVPSKEEIAPIVNEQLIVEFYSR"
     CDS             1382..1762
                     /locus_tag="ctg18_15"
                     /transl_table=11
                     /translation="VAVGNKLTGAGTGIAEAEAVHNIVQTKLKELKQNIAGNAAAAGGF
                     CIILAELAFKHTVLETQFLFFSKHHAIVGFLLAAGAHAMLAGREGALFKSLGGTEKGNA
                     KTAGHFIAGTGITSHDILDLYR"
     CDS             complement(1774..2325)
                     /locus_tag="ctg18_16"
                     /transl_table=11
                     /translation="MASEEITNETAEQPVEAAASAPVAETPAAAVSAPEEIKKPEPRKD
                     IFAELGLGGDDDKPKILKAKGSKNVSTGVVHVSSTFNNTVVTVTDQRGNVIGWSSAGKM
                     GFKGSRKSTAYAGQVVCQDACRQAMGHGLREVEVRVKGPGSGRESAVRAVQTIGIEITS
                     IKDVTPIPHNGCRPPKARRV"
     CDS             complement(2359..2736)
                     /locus_tag="ctg18_17"
                     /transl_table=11
                     /translation="MARLFGTEIPNEKRIEASLPYIYGIGRSTSKRILEQAGINPDIRT
                     GQLTDEQLTKIVQVITTDGILIEGDLRREKQSILKRLTSINCYRGQRHRRGLPVRGQRT
                     RTNARTRKGKKKTVGAQAKKK"
     CDS             complement(2855..3577)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_16"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1019:4Fe-4S dicluster domain (Score: 67.4; E-value:
                     5.3e-21)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg18_18"
                     /sec_met_domain="Fer4_16 (E-value: 2.2e-21, bitscore: 67.4,
                     seeds: 227, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 0.0013, bitscore: 10.3,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LQELLSIYGGKQRGYVDSGPVMERDHAEACGLGWRGKSGLIVRRK
                     GGSRFFIATLLTTLELEPDAPVSNGCGSCRRCAALCPTGAIMENGQVDAGRCLSYWTIE
                     HRGAIPEEIRPLIGTRLYGCDTCVTVCPWNGKPLPDVDERFRMSRLLASIPLRGLLSLD
                     AGGFAALFRNSPLKRLKREGLLRNGCVVLGNAGTPDDIDFLKALYGESPLVEEHASWAV
                     ERILRRHGRHASSSGARD"
     CDS             3812..4942
                     /locus_tag="ctg18_19"
                     /transl_table=11
                     /translation="MRAFFRTGHPAAGKTKLPGHGAQGIFNNRGIRSQHAGIMNKSMPP
                     TKNFLLSGGNWIACTPPPLHNAAYMNIRILSDGKQGHLNQSLGLAQALISKAGGTVETV
                     DLQGLSLLGKIRKVVTGSDIPRPDLFISAGHATHIPLICARHHFKTRAVLCMKPTLPCS
                     FFDLCLIPRHDLDSGRDYTDTDIFPTQGALHPMRPDPSVPKDTTLILIGGPSKDFDWDD
                     ESMLNQLASISIHTPGHLVLTTSRRTPDGFAEKIRTAVPELTVVPVEETRPGWVARHLA
                     HASAAWVSQDSVSMVYEALGSGAPVGILSVPRRHGSRKSRILSGLETLEKEGMVTGYSD
                     WKKQNFRLTAPGSPLLEADRAADYILSRFFPQLRAL"
     CDS             4996..6051
                     /locus_tag="ctg18_20"
                     /transl_table=11
                     /translation="MELGSGLSSRGVENIVVSGGGRLVPRLEKEGSRHILMPIGKKSIS
                     TLFRIGALRALLQAVRPDILHLHSRVPAWAGYLAWKKLPPEDRPGLVTSVHGFYSVNRY
                     SAIMSRGERVIAVSNCIRDYILDHYPSTPPDHIRIIPNAISPDQYHPAYSPSREWLTGW
                     FMSYPELKGKFTLCLPGRITRLKGHLDLIPVVRQLLEQGIPAHAVIVGEAKKGKEEYKN
                     EVLRAIERSGVSQSFTWTGHRQDLREILSTCSVTLSLTKSPEAFGKSTLEALALGKPVA
                     GYAHGGVKEQLDAFLPEGNVAVGDTASMADLLARWHAQPPPLPRQIPSPYNMQDMIQAH
                     LDVYQELTPYS"
     CDS             6048..7175
                     /locus_tag="ctg18_21"
                     /transl_table=11
                     /translation="MTPREAAIALNLIPGLGPVRIMRLLQVFASPELILESPSSLLMEI
                     PGVGAQLACRISSWRSIVNPYRELELADNAGAAVTTVFDDSYPSSLRALPDPPIVLYSW
                     GNWNGTDAERSIAVVGSRMATHYGRLCARNISHDLAEAGVTVISGLARGVDTEAHTGAM
                     DAEGRTIAVIGAGLNKLYPRENRNLAQRIADGHGAVVSEFPMDLSPSRTTFPMRNRIVS
                     GWSRATLVVEASGRSGALITARTAAEQGREVFCIPGPVDRHSSDGCHALIRDGAILATG
                     ASDILQDMNWAVPEQGLPLFSPCPPAGASTPLLPTLEEKEILHAIRLGFNTIDTLCTSL
                     GKAAHTITPLLAKMQIAGQITPDAGGYFSINGREL"
     CDS             7735..8658
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S11"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg18_22"
                     /sec_met_domain="Peptidase_S11 (E-value: 1.8e-55, bitscore:
                     178.7, seeds: 11, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRLFALLAGFSLCLSSTSCQSYGNSSDYIPLATPVPPQLSQPVSH
                     ALPRPANFPTRPVAIPSSAPRTPRCASACVMDALTGNVLFSHNGLQHRQVASTQKLVTA
                     MVVMEHGSLDKKVVIQPSDTKADPTKLGFRAGEVYSRRELLNAMMIRSFNDVALALARD
                     TAGSVPRFAQLMNAKARQMGMYNSRFANPNGLPADQYSTAIDMARCAYYVYRNPELRNI
                     ICKRQYAFTRANGRTLLLRNTNKLLTQNPWVTGMKTGYTNAAGRCLVSSAGVNGRHVIV
                     VVLGCHPSRIWTESENLIRWALGSAA"
     CDS             8717..9838
                     /locus_tag="ctg18_23"
                     /transl_table=11
                     /translation="MLQAGIVGLPNVGKSTLFNAVTRTRKAQAANYPFCTIDPNVGMVT
                     VPDPRLQVLSDMSGSEKIIPTLIEFVDIAGLVKGASEGAGLGNQFLANIREVDAIVQVV
                     RCFDNDDIIHELGSVDPLRDIDIINSELILADIATMEKRLSSRERKARSGDKEAKAEVA
                     LITKLLPHLNEGNPALTLEPQLDDDERKLLHSFQLLSDKKSIFACNVNEDELADAISNP
                     DAHPYVSQVKKYVAEHHNAEAIVISARIEEELIDVSEEESREFLESLGVKDSGVSDLIR
                     AVYHLLGLRTYLTTGIKETRAWTIPAGAKAPQAAGVIHTDFERGFIAAEVVHYDDLVSC
                     GGKAGAREHGKLRIEGKEYVVKDGDVIEFRFNV"
     CDS             10001..10999
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Glycine_cleavage: GCV_T_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Glycine_cleavage: GCV_T"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg18_24"
                     /sec_met_domain="GCV_T (E-value: 1.2e-78, bitscore: 254.7,
                     seeds: 72, tool: rule-based-clusters)"
                     /sec_met_domain="GCV_T_C (E-value: 7.2e-24, bitscore: 74.4,
                     seeds: 348, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPVQYTGILDEHKAVRETCGIFDISHMGQFTVAGGSAAAWLNSML
                     TNDINKLNVGQGQYSVMLNDRAGVIDDLILYRMEPETFFVVVNASKIDEDFAWLSAHQP
                     AGVTLENHSDEYVGLAVQGPECGEVFSRVIPGVELPPRNGISRITAEGTDLIICRTGYT
                     GEDGFEFFCPAKEGVKWFEAFLGAGAKPCGLGARDSLRLEMCYPLNGSDLSPDKTPLEA
                     GLGFFCALDTDFIGSDILREQKANGLSRRLAAIEYTGKGAPPRAHYAVHVPGGEAIGEL
                     TSGVLSPSLMKGIALAYLPAAHAKVGTELEIDVRGRKFPAVVVKKPFYKKG"
     CDS             11070..11450
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Glycine_cleavage: GCV_H"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg18_25"
                     /sec_met_domain="GCV_H (E-value: 4.4e-48, bitscore: 153.0,
                     seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHDVPENLLYSKDHEWIEIDGDIGTIGISDHAQAELSDVVFVDLP
                     EVGATVAAGDPVAVVESVKAASDVYTPVSGEILEVNEELSNDPSLINSDPYGAGWLYKI
                     RLDVPTETEDMMNATDYEEYCS"
     CDS             11546..14392
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Glycine_cleavage: GDC-P"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Beta_elim_lyase"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg18_26"
                     /sec_met_domain="Beta_elim_lyase (E-value: 7.7e-11,
                     bitscore: 32.5, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="GDC-P (E-value: 4.3e-179, bitscore: 586.5,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNTHSDFASRHIGPQGEERREMLDSLGYRTLDELIADIVPADIRM
                     KAPLDLPAAKSETEALEELRSILRKNKLLKTFIGQGYYGTITPSVILRNVLENPGWYTA
                     YTPYQPEIAQGRLEMLMNFQTMVSSLTGLPVANASLLDEGTAAAEAVTMCRNARPKANT
                     FFVADTCHPQTISVIRTRAAFQGVNIIVGDCSSFDPASIGADLAGVLVQYPDTLGRICD
                     YTDFFSRVHATGALCVVAADLMALTVIREPGAFGADICIGNTQRFGIPMGFGGPHAAYM
                     SCTDALKRRMPGRLIGMSIDTLGRPAYRLALQTREQHIRRDKATSNICTAQVLLAVLAA
                     FYAVYHGQEGLKRIGTEIHLKTKSLYKALTEAGIAIENKNFFDTLLLSVPGQADAMVQK
                     ALEAGYNIRRVDADHAAISLDETATCADIAALASALAGAETSAACDCDAPAWDPVHTRQ
                     TPFCTEKAFNSYHSETEMMRYIRRLESRDLALNEAMIPLGSCTMKLNAASEMIPITWPE
                     ANSLHPFVPADQSEGIREMLSVLSDRLAKITGFAAVSLQPNAGAAGEYAGLLAIRRYQK
                     HAGEGHRNVCLIPTSAHGTNPASSAMAGLKVVPVKCDERGNIDMADLKSQAEAHKDNLS
                     CIMVTYPSTHGVYEQTIKELCDIVHANGGQVYMDGANMNAQVGLTCPGCIGADVCHLNL
                     HKTFAMPHGGGGPGIGPIGVAEHLVPFLPGHLTLGHEEGAVASAAWGSASIAAICWMYL
                     SMMGPDGLREATEMAILNANYIAKKLGHLFPVLYSGNKGLVAHECILDPRQLTHDAGLT
                     VDDIAKRLMDYGFHGPTMSFPVPGTLMVEPTESEPKKELDRFIEAMERIHAEITAIING
                     TADKEDNVLKNSPHTAEMVSADEWRHPYSRSEAAYPVSGLLIHKFWPYVGRVDNVYGDR
                     NLVCTCDTVEEFSKAVEL"
ORIGIN
        1 accggagtcg gagcaacaat cttgacggga gtacccgcaa gagcagctcc ggcaaaggat
       61 gccacaactg ccgcaacact gatgatgttc ttggtttgca tgactattac ttggttaggg
      121 tattaattgt tgatttgcta acatggaaag aaaaatgctt tttcccccct tgttaagaaa
      181 agtgaaacat tttcgtcaca aaagtaaaga attttctctt gataaatcag caagtcattg
      241 atttcacatt atttacatcc accaacccca tgacaaaaaa tccaattctc catatcttgc
      301 caaaccttcc cttccaaggc ctggccggat acagacactc cgcaccatcc agaagcctgt
      361 cttctttcag ggcaggagaa ggattcacca gaaccctccg cctgcaggaa agcagcatgg
      421 gcagatccgc ggcactgtcg ctgtaggcaa cggcgttttc cagaacacca tgttccggca
      481 gtacattccg ctcccgcaga cgctccacct tcaccgcccc cttattatta ccgttcggca
      541 gttccggcat tgccggcatg cgttcctcca gaagcacatc cgttcccaga acttcgtcaa
      601 atcccagcag ttcgcccagg ggcttcacgt aaaatgatgg agaagcggaa accatgagac
      661 acaaataacc cttcttccga taccctgcca gccgctcctt cagctccgga taaatccatt
      721 cctgcgccat ctcggcaaac ttccgtccat attcccgcac cgtttcagcg ggaagccccc
      781 acaaatacat gagataagcc ctcttcatcc ggttctcatc ccatattctc aaaatataga
      841 gcgggataca ggccaggaaa agaaaaatca gcaagcgtct ccaaggatgg cgcctcacca
      901 caaaacagga aaaaatatat tgcgtatccc agggaaggag cgtgccgtcc atatcgaaaa
      961 gcgctgcgcc tctttttttc caatcgtccg tcatgctttc atcctatacc agcttccctt
     1021 aactctcaac acccaactct tccatgcccc tccccccctg aatgcccaaa accccggccg
     1081 ccgaaaggca accggggttt tgaagcaaat ccagaaggaa ataagattaa cgggagtaga
     1141 attccacgat gagctgctca ttgacgatgg gagcaatctc ttccttggaa ggcacgcggg
     1201 caatcttgcc cgtgagcttg tcacggtcgc attccagcca gtcaggaacc acagtagcct
     1261 gagtcaggtc aagggaacgg gtaaccagct gctgggaaga agccttgccg cctacggcaa
     1321 tgacgtcgcc cggacggcag gagtaggacg cgatattcgt cttcttgccg ttcacggtga
     1381 tgtggccgtg ggaaacaagc tgacgggcgc cggcacgggt attgctgaag ccgaggcggt
     1441 acacaacatt gtccagacga agctcaagga gctgaagcag aatatcgccg gtaatgccgc
     1501 ggcggcgggc ggcttctgca taatacttgc ggaactggcc ttcaagcaca ccgtactgga
     1561 aacgcagttt ctgtttttca gcaagcatca cgccatagtc ggatttcttc ttgcggccgg
     1621 cgcgcatgcc atgctggccg ggagggaagg ggcgcttttc aagagccttg gtggaaccga
     1681 aaagggcaac gccaaaacgg cgggacactt tatcgcgggg accggtataa cgagccatga
     1741 tatattagat ctatataggt aaaagattct caattagacg cggcgggcct tcggaggacg
     1801 gcagccgttg tgggggatgg gggtcacgtc cttgatggag gtgatttcaa taccgatcgt
     1861 ctgcacggca cgtacagcgg attcacgacc ggaaccgggc ccctttacgc gcacttccac
     1921 ttcacgcaag ccgtggccca tggcttggcg gcaggcgtcc tggcacacca cctgcccggc
     1981 ataggccgtg ctcttgcggg aacccttaaa gcccatcttg ccggcggagg accagccgat
     2041 gacattgccg cgctggtcag tcacagttac gacggtgtta ttgaacgtgg aggaaacgtg
     2101 aaccacgccc gtggaaacgt ttttgctgcc cttggccttc aggattttgg gcttgtcatc
     2161 atcgccgccc agaccaagtt ccgcaaagat atccttgcgg ggttcgggct tcttgatttc
     2221 ttcaggagcg gaaacagcgg cggccggagt ttcagcgacg ggagcggaag ctgccgcttc
     2281 cacaggctgt tcggcggttt cgttggtgat ttcttcgcta gccatagtaa agctatatta
     2341 aaaattcagg ttggcggatt acttcttctt ggcctgcgcg ccaacggtct tcttcttgcc
     2401 tttacgggtg cgggcattcg tgcgggtacg ctgaccgcgt accggaaggc cgcggcggtg
     2461 gcgctgacca cgatagcagt tgatggaggt cagacgcttg agaatggatt gcttttcacg
     2521 acgaaggtca ccttcaatca aaatgccgtc ggtggtgatt acttgaacaa tcttcgtgag
     2581 ctgttcgtcg gtaagctgtc ccgtgcggat gtcgggattg atgcctgctt gttccaggat
     2641 tctcttagaa gtcgagcgac caattccgta aatatacgga agggaagcct cgatgcgctt
     2701 ctcgttgggt atttctgtac cgaaaaggcg tgccataatg gattggattt gctagctgtt
     2761 atttttctct gcctcgcgca gagctattgc ttggggcaag atggatacca taaattgagg
     2821 ttttgacaag accaaaacat cattttttct atttttaatc tcttgcaccg cttgaagatg
     2881 catgccgccc gtggcggcgg aggatgcgct ccacagccca ggaagcgtgt tcctccacca
     2941 gaggagactc cccgtaaagc gccttcagaa aatcaatgtc atccggagtc cccgcattcc
     3001 ccagcacaac gcagccgtta cgcagcagcc cttccctctt gagccttttc aacggggaat
     3061 tccggaacag ggccgcaaaa ccgccggcat ccagggaaag aagaccacgc aggggaatgg
     3121 aagccagcag acgggacatg cggaaccgtt cgtcaacgtc cggcaaaggc ttaccattcc
     3181 agggacagac cgtcacgcag gtatcgcacc cgtacaggcg cgtgcctatc aggggacgga
     3241 tttcttccgg aatagccccc cggtgttcaa tcgtccagta ggaaaggcag cgtccggcat
     3301 caacctgacc gttttccata attgcgcccg tcggacacag ggccgcacaa cggcggcaac
     3361 tgccgcatcc gtttgaaacc ggagcgtccg gttccagttc cagcgtagtc agcagggtag
     3421 cgataaaaaa gcgggagccc cctttcctgc gcacgatcaa accgcttttc ccgcgccagc
     3481 ccaggccgca ggcctccgca tggtcccgtt ccataacagg gccggagtcc acataccccc
     3541 tctgcttccc gccgtaaatg gaaagcagct cctgcaaatc cgccagtttt tcctccagaa
     3601 ttccgtggta atcctttcca tgggcgtaaa ggcaaatgct accctccccc tccgggcgcc
     3661 taccggggct gtcataatca taggacaggc aaatgactga acggcatccg ggaagcactt
     3721 ccgcaggatc cgtgcgccgc tccggggaac gcgccatcca ctccatcccg gcgtgccatc
     3781 cgcgctccag ccattgaaac aatttttccg catgcgggct tttttccgca cgggccaccc
     3841 ggcagccgga aaaaccaagc tgccgggaca cggcgcacaa ggaatcttta ataacagagg
     3901 aatccggagt cagcacgccg gaatcatgaa caagagcatg cctcccacca agaattttct
     3961 tctgtccggt ggaaattgga ttgcctgcac cccgccgccg cttcataatg ccgcatatat
     4021 gaacatccgg attctgagcg atgggaaaca gggccacctc aaccagtccc tggggctggc
     4081 gcaggctctg atctccaaag cggggggaac cgtggaaacg gtagacctgc aggggctttc
     4141 ccttttgggg aaaatccgga aggtcgtcac aggcagcgac attccacggc cggatctgtt
     4201 catttccgcc ggacatgcaa cgcatatccc gctcatctgc gcgcggcacc atttcaaaac
     4261 ccgggccgtc ctctgcatga agcctacgct tccctgttcc tttttcgacc tctgccttat
     4321 tccccgccat gacctggatt ccggccgcga ttacacggat acggatatct tccccaccca
     4381 gggagctctc caccccatga ggccggatcc ctccgtacca aaggatacca cactgattct
     4441 cataggaggg cccagcaaag attttgactg ggatgacgaa agcatgctca accagctcgc
     4501 gtccatcagc atccacaccc ccggacacct tgttctaacc acctcgcgcc ggacgccgga
     4561 cggctttgcg gaaaaaatcc ggacggccgt tccggaacta accgtcgttc ccgtggagga
     4621 aacccggccg gggtgggtag cccggcatct ggcgcacgcc tccgccgcct gggtcagcca
     4681 ggacagcgtc tccatggtat atgaggctct tggctccggc gcgcctgtag gcatcctttc
     4741 cgtaccgcgc cgacacggca gccgcaaatc ccgcatcctg tccggcctgg agacactgga
     4801 aaaggaaggc atggttactg gatacagtga ctggaaaaaa cagaacttcc gcctgacggc
     4861 tcccggttcc ccgcttctgg aagcggaccg tgcagcagac tacatcctct ccagattttt
     4921 ccctcagctc cgcgccttat gaaaatagta catctcgtcc cctccatgga atccggaggc
     4981 gtggaacaag tcgttatgga actgggcagc ggcctttctt cccggggcgt ggaaaatatc
     5041 gtcgtttccg gaggcggacg cctggtgccc cgtctggaaa aggaaggctc ccgccacatc
     5101 ctgatgccga taggcaaaaa aagcatctcc actctcttcc gcatcggggc cctccgcgcc
     5161 ctgcttcagg ccgtcaggcc ggatatcctg catctccatt cccgcgttcc tgcgtgggca
     5221 ggctacctgg catggaaaaa gctcccgccc gaagaccgtc ccggcctcgt caccagcgtt
     5281 cacggcttct actccgtcaa ccggtactcc gccatcatga gccggggaga gcgggtgatc
     5341 gccgtctcca actgcatcag ggactacatc cttgaccatt atccgtccac ccctccggac
     5401 catatcagaa tcatacccaa tgctatttcc ccggaccaat atcacccggc ctactccccc
     5461 tcccgggaat ggctcacggg ctggttcatg tcctatcctg aactgaaggg gaaattcacc
     5521 ctgtgcctgc cgggccgcat cacgcgcctg aaagggcatc tggatctgat tccggtcgtc
     5581 aggcagcttc tggaacaggg aatcccggcc cacgccgtca ttgtaggaga agcaaagaag
     5641 ggaaaagaag aatataaaaa cgaggtcctg cgggcaatag aacgttccgg cgtctcccag
     5701 tccttcacct ggacaggaca tcgccaggat ctgagggaaa tcctttccac atgttccgtc
     5761 accctctccc tgaccaaaag cccggaagcc ttcggcaaat caaccctgga ggcgctcgcc
     5821 ctgggcaaac ctgtggccgg atacgcccac ggcggagtca aggaacagct ggacgccttc
     5881 cttcctgaag ggaacgtcgc cgtaggagat accgcctcca tggcggacct gctggcccgc
     5941 tggcatgccc agcccccccc cctgccccgg caaattcctt ccccttacaa tatgcaggat
     6001 atgattcaag cccatctgga cgtttaccag gaactgaccc cttattcatg acaccccggg
     6061 aagcagccat agccctgaac ctgataccgg gcctgggccc tgtcagaatc atgcgtctcc
     6121 tgcaggtatt cgcctctccg gaactgattc tggaatcccc ttcctccctg ttgatggaaa
     6181 ttcccggcgt gggggcgcag ctggcttgcc gcatttcctc ttggcggagc atcgtcaacc
     6241 cgtacaggga actggaactg gcggataacg cgggggccgc agtaaccacg gtttttgacg
     6301 actcctaccc atcctccctg cgtgctctcc cagacccgcc cattgtcctc tactcctggg
     6361 gaaactggaa cggaacggat gccgaacgct ccattgccgt cgtcggctca cggatggcca
     6421 cccattacgg caggctttgc gccagaaaca tctcccatga cctggcggaa gccggagtca
     6481 ccgtcatttc cggactggcg cgcggtgtgg acacggaagc ccataccggg gccatggacg
     6541 cggaggggcg caccatcgcc gttatcgggg caggtctcaa caaactgtat cctcgggaaa
     6601 acagaaactt ggcgcagcgc attgcggacg ggcatggagc ggtagtctcc gagttcccaa
     6661 tggacctgtc cccctcccgc accacttttc ccatgcgcaa ccgcatcgtg agcggctgga
     6721 gccgcgctac gctggtggtg gaggcgtccg gacgcagcgg ggccctgatc acggcccgaa
     6781 cggcggccga acagggccga gaggttttct gcattcccgg accggttgac cggcattctt
     6841 ccgacggatg ccatgccctc atccgggacg gagccatcct ggctaccgga gcctccgata
     6901 ttctgcagga catgaactgg gccgttccgg aacagggact gcctctcttc tcgccatgtc
     6961 cccctgccgg agcctcaacc ccactgcttc ccactttgga agaaaaggag attctccacg
     7021 ccatcagact gggtttcaat actattgaca ccctctgcac ctctctggga aaagcggcgc
     7081 ataccatcac cccgcttttg gccaaaatgc aaattgcagg gcaaattact ccggacgccg
     7141 gagggtattt ctccattaac ggcagggaac tttaggaaga ttccgctttt ccgccgggga
     7201 aaacgccagg tccgggcctc ctctccctga ccatggaacc ggaagggagc gccgtccatc
     7261 tcccgtataa aaacctttcc atccggatgc aaaaaaacgt cttaaaacag tcgccaaatc
     7321 ctttccttca ataattttat tccaaaaatt aaatatatcg gcaggacatc cccggcattt
     7381 taaatgcctg cggtaaattt acatgctcgc gaaaaacaaa atatgttcgg aaaaaatctc
     7441 tgccatattt actggacgca ggctcgggct catacggcaa cacctcttaa aaagaattgt
     7501 tgacgaacat attttgaacg catcactcct gcctggagtc tcatccttca caagatctgt
     7561 ccgacggatg ggaaaagcaa ttcaaaatcc gttcagggtg gtttttggtt ccataggtag
     7621 ttaatagaga aaaaaggccg cggattgtcc gatccgcggc ctttttcgtc cggctctctt
     7681 tcaaatgcgg agtttgggct tgatgaacga aacttcttac tgtagcaaca agacatgcgt
     7741 ttattcgccc ttcttgcagg attctccctt tgcctgagct ccacaagctg ccaatcgtac
     7801 gggaattcaa gtgactacat cccccttgca acgcccgttc ccccacaact ctcccagccg
     7861 gtttcccatg ccctcccccg accggccaat ttccccacac gtcccgtagc catcccctca
     7921 agcgccccac gcacgccccg ctgcgccagc gcctgcgtca tggacgccct taccggcaac
     7981 gtgctctttt cccacaacgg cctccagcac cgccaggtag ccagcacgca gaaactcgtg
     8041 acggccatgg tcgtgatgga acacggcagc ctggacaaaa aagtggtcat ccagccttcc
     8101 gataccaagg cggaccccac caaactggga ttccgggcgg gggaagtcta ttcacgccgc
     8161 gaactgctca atgccatgat gatccgcagt ttcaacgacg tagccctggc tctggcccgc
     8221 gatacggcgg gttccgttcc ccgtttcgcc cagttgatga atgccaaagc ccggcagatg
     8281 ggcatgtaca actcacgctt cgccaatccc aacggcctcc cggcggatca atattccact
     8341 gccattgaca tggcccgctg cgcctattat gtgtaccgca acccggaact gcgcaatatt
     8401 atctgcaaac gccaatatgc ctttacccgc gccaacggca gaacgcttct gctgagaaac
     8461 accaacaagc tgctcaccca gaacccctgg gttaccggaa tgaaaaccgg atacacgaac
     8521 gccgccggac gctgcctggt ttcctcagcc ggcgtcaacg ggcgccatgt catcgtcgtc
     8581 gtcctcggct gccatccgtc ccgtatctgg acggaatcgg aaaacctgat cagatgggct
     8641 ctgggatccg ccgcataaat gcccgtcggc aattggtatt tgactttcac ggcgtgaccc
     8701 gctatcagtc ctgcctatgt tacaggcagg tattgtaggt ctccccaacg tcggcaaatc
     8761 cactctattc aatgcggtca cccggacgcg caaggcccag gcggccaact atcccttctg
     8821 caccattgac ccgaacgtgg gtatggtaac agtcccggat ccccgcctgc aggttctttc
     8881 cgacatgtcc ggttctgaaa aaatcatccc cacgcttatt gaattcgtgg atattgccgg
     8941 tctggtcaag ggagcctcgg aaggagccgg cctgggcaac cagtttctgg cgaacatccg
     9001 tgaagtggac gccatcgtgc aggtagtccg ctgctttgac aatgatgata ttatccatga
     9061 actcggttcc gtggatcctc tgcgcgacat tgacatcatc aactcggaac tcattctggc
     9121 ggatatcgcc accatggaaa agagactctc ttcccgcgaa cgcaaggcac gcagcggcga
     9181 caaggaagcc aaggccgaag tggccctcat caccaaactc ctgccccacc tgaacgaagg
     9241 caatcccgcc ctcacccttg aaccgcagct ggacgacgat gaacgcaagc tgctccattc
     9301 tttccagctg ctttcggata aaaaaagcat tttcgcctgc aatgtcaatg aagacgaact
     9361 ggcggacgcc atctccaacc cggacgccca tccctacgtc tcccaggtga aaaaatacgt
     9421 agcggaacac cataacgcgg aagccattgt catctccgcc cggattgaag aggaactcat
     9481 cgacgtctcg gaggaagaat cccgcgaatt cctggaatcc ctgggtgtga aggactccgg
     9541 cgtttccgac cttatccgcg ccgtgtacca ccttctgggc ctgcgcacct acctcaccac
     9601 gggaatcaag gaaacgcggg cctggaccat tccggccggg gcaaaagcac cccaggcggc
     9661 cggcgtcatc cacacggact ttgaacgcgg ttttatcgcc gcggaggtag tgcactacga
     9721 cgacttggtt tcctgcggcg gcaaggccgg agcgagggaa cacggcaagc tgcgcatcga
     9781 aggaaaagaa tatgtcgtca aagacgggga cgtcatcgaa ttccgcttca atgtctagac
     9841 ggaagcgtta ccggaattcc attgactttt actgatataa ggggcagatt gctcataacc
     9901 ttcacatcgc ctcatgactg atacagacgt caaatccacc cccctggcaa ctaaacacgt
     9961 tgaactggga gccagaatgg ttcctttcgc cggctggaat atgccggtgc agtacaccgg
    10021 cattctggac gaacacaaag cagtgcgcga aacctgcggc atttttgaca tctcccacat
    10081 ggggcagttc acggtagccg gcggttccgc tgcggcatgg ctgaactcca tgctgaccaa
    10141 tgacatcaac aaactgaatg tagggcaggg gcaatactcc gtcatgctca atgacagggc
    10201 cggagtcatt gacgacctca tcctgtaccg gatggaaccg gaaaccttct tcgtagtggt
    10261 gaacgcctcc aagattgatg aagacttcgc atggctttcc gcccatcaac ctgcaggcgt
    10321 aactctggaa aaccactccg acgaatacgt ggggctggct gttcaaggtc ccgaatgcgg
    10381 agaagtattc tcccgcgtca tccccggcgt ggaacttccc ccccgcaatg gaatctcccg
    10441 catcacggcg gaagggacgg atctcattat ctgccgcacc ggctataccg gggaagatgg
    10501 ttttgaattc ttctgcccgg ctaaggaagg cgtcaaatgg tttgaagcct ttcttggagc
    10561 aggagccaaa ccctgcggcc tgggcgcccg cgacagcctg cgtctggaaa tgtgctatcc
    10621 tctgaacggc tccgacctct ctccggacaa aacgcctctg gaagccgggc tcggattctt
    10681 ctgcgcgctg gatacggact tcatcggttc cgatattctc cgggaacaaa aagccaacgg
    10741 cctcagccgt cggctggccg ctattgaata caccggcaag ggagctcctc cccgcgccca
    10801 ctatgccgtg cacgtccccg gtggagaagc catcggagaa cttaccagcg gcgtgctctc
    10861 tccttcgctg atgaagggca ttgccctggc ctacctgcct gccgcccatg ccaaggtcgg
    10921 cacggagctg gaaattgacg taaggggaag gaaattccca gccgtggtcg taaaaaaacc
    10981 cttttataaa aaaggctgac actacggcgc aaaaataaac tgacaaacac ctcattttac
    11041 tacactctca cttcaaacaa ttacatctta tgcacgacgt accagaaaat ctgctgtatt
    11101 ccaaagatca cgaatggatt gaaattgacg gggacatcgg caccatcggc atttccgacc
    11161 atgcccaggc cgaactctcc gatgtcgtct ttgtagacct tcccgaagta ggcgccaccg
    11221 tcgcagctgg cgaccctgtc gctgtcgtgg aatctgtcaa agctgccagc gacgtgtaca
    11281 cccccgtttc aggagaaatc ctggaagtga acgaagagct ttccaatgat ccgtccctca
    11341 ttaactccga cccctacggc gcaggctggc tgtacaaaat ccgcctggac gttcccacgg
    11401 aaacggaaga tatgatgaac gccacggatt acgaggaata ctgctcctga accattcttc
    11461 cctcccccgc cccggtgatt ccatcccggg gcattttgtt tggcccgttc cgcggccgga
    11521 cgctattacc agccagagat accacatgaa tacccactca gattttgcca gccggcacat
    11581 cggcccccag ggggaagaac gccgggaaat gcttgacagc ctcggctacc ggacgcttga
    11641 cgaactcatt gcggacatcg tccccgcaga tatccgcatg aaggccccgc tggacctgcc
    11701 cgcagccaaa tcggaaacgg aagccctgga ggaactccgt tccattctgc ggaaaaacaa
    11761 gctcctgaaa accttcattg gccagggcta ttacggcacc atcactccct ccgtcatcct
    11821 ccgcaatgta ctggagaacc ccggctggta cacggcctac accccttatc aaccggaaat
    11881 cgcccaggga cggctggaaa tgctcatgaa tttccagacc atggtctctt ccctgacagg
    11941 gctgccggta gcgaacgcct ccctgctgga tgaaggcacc gcagcagcag aagcagtcac
    12001 catgtgccgg aacgcgcgcc ccaaagcaaa caccttcttt gtggcggaca cctgccaccc
    12061 ccagaccatc agcgtcatcc gtacccgcgc cgccttccag ggcgttaaca tcatcgtggg
    12121 agattgctcc tcctttgacc ccgcatccat cggtgcggat ctggccggag tgcttgtcca
    12181 atatccggac acgctcggcc gcatctgcga ctacacggac ttcttttccc gcgtgcatgc
    12241 cacgggcgcg ctctgcgtcg tggcggcgga tctcatggcc cttaccgtca tccgggaacc
    12301 cggcgccttc ggagccgata tctgcatcgg caacacgcag cgcttcggca tcccaatggg
    12361 cttcggcggc ccccatgccg cctacatgtc ctgcacggac gctctcaaac gccgcatgcc
    12421 cggccgcctt atcggcatgt ccatagatac cctgggccgc ccggcctacc gcctggccct
    12481 gcaaacgagg gaacagcata ttcgccgcga caaggcgacc tccaacatct gcaccgccca
    12541 ggtgctcctg gccgtgcttg ccgcctttta cgccgtatac cacggccagg aaggcctcaa
    12601 acgcatcggc acggaaatcc acttgaaaac caaaagcctg tacaaggcgc tcacggaagc
    12661 cggcatcgcc attgaaaaca aaaacttctt tgacaccctg ctgctgtccg ttcccggaca
    12721 agcggacgcc atggtgcaaa aagccctgga agccgggtat aacatccgca gggtggatgc
    12781 cgaccacgca gccatctctc tggatgaaac cgcaacctgt gcggatatag cggcactggc
    12841 ctccgccctt gctggtgcgg aaacatccgc cgcctgcgat tgcgacgctc ctgcctggga
    12901 tcccgtccac acgcgccaga cgcctttctg cacggaaaag gctttcaact cctaccattc
    12961 cgaaacggaa atgatgcgct acatccgccg cctggaatcc cgggacctgg ctctaaatga
    13021 agccatgatc cctctgggct cctgcacgat gaagctgaac gccgcctctg aaatgattcc
    13081 catcacgtgg ccggaagcca actccctgca tccctttgtt ccggcggacc agtcggaagg
    13141 catccgggaa atgctctccg tcctgtccga ccgtctggcg aaaatcaccg gctttgccgc
    13201 cgtatccctc cagcccaacg ccggcgccgc aggggaatat gccgggctac tggccatccg
    13261 ccgctaccag aagcacgccg gagaaggcca ccgcaatgtc tgcctcattc ccacctccgc
    13321 ccacggaaca aatcccgcat cctccgccat ggccggcctc aaggtggtgc ccgtcaaatg
    13381 cgacgaaaga ggcaacatcg acatggcaga cctgaaatcc caggcggaag cccataagga
    13441 caatctctcc tgcatcatgg tcacgtaccc ctccacgcac ggggtatatg aacagacaat
    13501 caaggaactc tgcgacatcg tccatgccaa tggcggccag gtgtacatgg acggcgccaa
    13561 catgaatgcc caggtaggtc tgacttgccc cggctgcatt ggcgcggacg tctgccacct
    13621 gaacctgcat aaaacctttg ccatgccgca cggcggcggc ggtcccggca tcgggcccat
    13681 cggcgtagcg gaacacctcg tacccttcct gcccgggcac ctcacgctgg gccatgaaga
    13741 aggggccgta gcgtctgcgg cgtggggaag cgcctccatc gccgccatct gctggatgta
    13801 cctctccatg atggggccgg acggcctcag ggaagccacg gaaatggcca tccttaacgc
    13861 caactacatt gccaagaaac tcggacatct cttcccggtt ctctactccg gcaacaaggg
    13921 gctggtggcg catgaatgca ttctggatcc gcgtcagctc actcatgacg ccggcctcac
    13981 ggtggatgac attgccaaaa ggctcatgga ctacggcttc cacggcccca ccatgtcctt
    14041 ccccgttccg ggcaccctga tggtggagcc gacggaatcg gaacccaaaa aagaactgga
    14101 ccgcttcatt gaagccatgg aacgcattca tgcggaaatc acggccatta tcaacggtac
    14161 ggcagacaag gaagacaacg tcctgaaaaa ctcgccccat accgcagaaa tggtctccgc
    14221 cgacgaatgg cggcacccct actcccgcag tgaagcggct tatccggtct ccggtctcct
    14281 tattcacaaa ttctggccgt atgtaggccg ggtggataat gtgtacggag accgcaatct
    14341 ggtctgcacc tgcgacacgg tggaggaatt ctccaaggcc gtagagttat aaaaatctca
    14401 tccttccttt caaaaaggct gttccattca tttggagcag cctttttctt atgttcaaga
    14461 atcggatttc caatccgaaa gagcaaacat atccagaaaa caattaagcc caaaagc
//
