LOCUS       c00015_gnlPro..        14946 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|JBDHBGEL_15.
ACCESSION   c00015_gnlPro..
VERSION     c00015_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-05 02:20:18
            Original ID  :: gnl|Prokka|JBDHBGEL_15
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 127938
            Orig. end    :: 142884
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14946
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[137938:142796]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /neighbourhood="10000"
                     /product="TPP_fatty_acids"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..14858
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /neighbourhood="10000"
                     /product="TPP_fatty_acids"
                     /protocluster_number="1"
     cand_cluster    1..14946
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /kind="single"
                     /product="TPP_fatty_acids"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14946
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_fatty_acids"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /tool="gutsmash"
     CDS             complement(860..1525)
                     /locus_tag="ctg15_109"
                     /transl_table=11
                     /translation="MRKIETEKTMRKEERYKGVLNWFKENVPVAETELHYDDPYQLLIA
                     VILSAQCTDKRVNMITPALFEAFPTPEVMAASTPEVVFEYIRSVSYPNNKAKHLVGMAK
                     MLIEDFKGVVPSDIDELQKLPGVGRKTANVIASVVYDKPAMAVDTHVFRVSNRIGLTNN
                     SKTPLETEKELVKNIPEELIPIAHHWLILHGRYVCLARKPKCEECGLKPWCKHFLKQT"
     CDS             complement(1667..4180)
                     /locus_tag="ctg15_110"
                     /transl_table=11
                     /translation="MKTLKYLLATMLLLCVCNLTHSQKLSLGIFPEPQEVTISSQTYAP
                     PHGYTLRGINNPDADAVKLLKEALPFAKSGKSLPLEIKKLKDKTPEMQRSGAYTLTITK
                     KGITIGIVDDNSLFYAAQTLKQLAKYDEGKKILPLCSIKDYPDVLFRGTVEGFYGQPWS
                     HADRIEQIRFYGRIKLNTYIYGPKDDPYHSSPNWRKPYPAEEAEHIKELAKEAAHNKVN
                     FVWAIHPGQDIQWNLTDSMNILSKFEKMYDLGVRSFAVFFDDISGEGARPEKQAGLLNY
                     IHKEFITKKNDVQPLIMCPTEYNRSWAKTDYLDILGTQLDPAIQIMWTGDRVVADITKE
                     GVEWVNSRIRRPAYIWWNFPVSDYCQDHLLMGPAYGLDTQAAGTMTGFVSNPMEYAEAS
                     KVAIFGVGMYTWNIKNYDPTQAWKDACDFIMPEASMAFRIFCEHNCDPGPNGHQYRREE
                     SANYVAPIQTFLTGYKKNTFPEQSANLLGTLFAQITASPSMIYSQSPNKRLIEQINPWL
                     IQFEFLGKAGTSALHMAHAWYEKDRSYTWQRYLETSALLDSMKLINRTLNQKAQPKGVK
                     VGSKVLHPFIVDLYRQTGRNLLSTDGIAPDEVKVSIPSIFTNIDQLKSQPCAEGDNTVG
                     YVPLFEVVKVQPNQYLGIGWEIQKEAESFCFNLPKSNQPGRVFEWSADGKSWSLIPHVS
                     TENAKDTIRTIDPKARYIRMRNNSDQQMELYVLGFTATTKQDPQINEALMMYDMNLDTY
                     KNLNPGEIIHIKCDDINAVSFFLSGSNENLVSITGLSQDGEKNIVYQGNVGYIKLNKTM
                     FEDFSSLEITTIGKEPIHIHQIVRE"
     CDS             complement(4328..5926)
                     /locus_tag="ctg15_111"
                     /transl_table=11
                     /translation="MIKITYKLILLLGLLAMTVTSFAASEAEYGKVSKAWTLHADGSQE
                     YRSSMELTLFTHTAMNSTYGESFIVYNPDFQTLKIHSSYTRQKDGTIVKTPDNAFVEVL
                     PRFAADAPAYNQLKEMVVVHTGLELGATIYLDYSIITKPGYYPAMDINERLQETSPVKE
                     CKVSISVPENSPLAWQLLGSDAKASQATRNGAKEVSWTLRNLPASSREAFLPQNQDGIP
                     RLIASSYSSNKEALSTLNKRFNTSGNYESKTFGSYITEKATSDEEKVNAIRNHVVNNMG
                     YCAIPLACTGYSIRDVDTALRSAYGTLAEKTQLLNVLLNAAGIQSEVVAVYPGNLDIDA
                     CGLSTIKNLAVKATVAGKDKYLSAVSLAPSALTARGELDQVLTLNGTSIALQAEPTIIK
                     ENKAVSVSKNEAQNGFAICTLPAITGGIDSWGMSALNSKRSNLFELPSLIKEEVTYTVT
                     PAEGMKLQTSTKEQVISKPFGKVTRTITPRGNTIEVVRTIELDKQQFTPAEYSDVRSLI
                     HEWTNPDNRVLLFSL"
     CDS             complement(5940..7901)
                     /locus_tag="ctg15_112"
                     /transl_table=11
                     /translation="MKRILTITAVSLLALSPMYGQDSCRYPQDPTLEKSQAYAGYDCVT
                     LLDSTAVTVQPTGSGAFAVCKAFKVQTSKGAVANRIIKYDYDPLTAHAEFRYATIYRAN
                     GDVINLDVTQACDYAAPARAIYWGARQIMLEVGRLQPGDIVEYEIAKKGFTYALLTAGD
                     DDERFIPPMRGQFYDIVPFWATEPTVRKVYRVSMPMEKELQFQFYQGECTSSMRYEDRR
                     KVYTFASDDILPFAKEPNMVDLFDAAPKLMMSSTPRWEDKSLWFNKVNEDYGSFTAIPE
                     AQKKVDELIKGKKTEMEKIAVLTHWVADNIRYSGISMGKGEGFTLHNLKMNYTDRCGVC
                     KDIAGTLIAFLRMAGFEAYPAMTMAGSRVESIPADHFNHCVAVVKLASGTYMPLDPTWV
                     PFCRELWSSAEQQQNYLPGVPEGSDLRLTPVSAPENHYVRIHADNRLDEKGTLRGQFTI
                     TAEGQSDSNIRRIFTTGWQSDWQNTMEKQLLAVSPNAKLLRVDYGKDPKNYQAAPIKIT
                     FSYEIPDYAIIAGDQMLIKPLVMNNLYNQVKSFLRIDTKPENRAYGFKDACSRLVEQDE
                     TIRLPKGYTLLNAPKNDVLQSNAADFEGSLSQEGNQNIVLRQKLALKKRVYDAADWKGF
                     RSAVNAYKSYGDYLIIKK"
     CDS             complement(7904..8902)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1025:AMP-binding enzyme (Score: 53.3; E-value:
                     5.7e-17)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg15_113"
                     /sec_met_domain="AMP-binding (E-value: 1.1e-16, bitscore:
                     53.3, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPIQEDLQAFLAEWHDPSPFLEVQTSGSTGTPKRMRVRKDRMLNS
                     ARLTCDYLGLKKGDKALLCMPLRYIAGKMMVVRSLYAGLDLEVCEPSGHPLADWGDTPL
                     RFAAMIPLQVYNTLRVPEERKRLEQTDILIIGGGAIDAALEQEIRQMPNTVYSTYGMTE
                     TLSHVALRRLNGPEASPYYHPFPSVTLSLSPDNTLVIDAPLVCDERLVTNDVARLLPDG
                     SFAIIGRKDNIINSGGIKIQIEEVEERLRPYLDRPYAITATPDPRLGEAVVLLLASNLR
                     GEMLTEVLANLPKYLRPRHIIKVSEIPQTGSGKIDRAACRELARNIITKTL"
     CDS             complement(8906..9964)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MR_MLE_C"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg15_114"
                     /sec_met_domain="MR_MLE_C (E-value: 1.9e-29, bitscore:
                     95.7, seeds: 401, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVKERLYRIEVVPRCLTFKRPAGTSRGVYTTRKLWEVRIRKEDEP
                     SVIGIGECAPLPDLSCDYGVDYEITLSKACLDLEQKGYVDTESLRHYPSILFGLETAMR
                     HYEQGGWRHYDTPFSQGQAGIPINGLIWMGDYKYMLEQVEEKMKEGFRCVKLKIGAIDF
                     DRELSLLKHIRAHFSAKEIELRVDANGAFTPSEAMDKLKRLAEMDLHSIEQPIRAGQLE
                     EMARLAAESPLPIALDEELIGCNAPDEKRRLLETIHPQYIILKPSLHGGIAGCTEWVHL
                     AETILGSTPEQPKWWVTSALESQIGLNAIAQWCATLGNPLPQGLGTGEIFKDDKHKLIQ
                     RKGDTIWFTNDL"
     CDS             complement(10001..10825)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: ECH_1"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg15_115"
                     /sec_met_domain="ECH_1 (E-value: 3.1e-81, bitscore: 265.2,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="METKREWTTIKEYEEILFDFYNGIARITINRERYRNAFTPTTTTE
                     MSDAFYICRERPDINVVVLTGAGDTAFCAGGDMNVKGRGGYVGKDGVPRLNVLDVQKQI
                     RSLPKPVIAAVNGFAIGGGHVLHVVCDLTIASENAIFGQTGPRVGSFDAGFGSSYLARV
                     VGQKKAREIWFLCRKYNAQEALDMGLVNKVVPLDKLEDEYVQWAEEMMLLSPLALRMIK
                     AGLNAELDGQAGIQELAGDATMLYYMTDEAQEGGKAFLEKRRPRFEDYPKFP"
     CDS             complement(10829..12517)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg15_116"
                     /sec_met_domain="TPP_enzyme_C (E-value: 8.5e-07, bitscore:
                     21.8, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYSDKKNILQLVALLIEHGVSNIVLCPGSRNSPIVHTLANHSFFN
                     CHSVTDERSAGFFAVGLALHGGKPAAVCCTSGTALLNIHPAVAEAFYQKVPLVVISADR
                     PAAWIGQMDGQTLPQPGVFGSLVKKSVQLPEIHTDQDEWYCNRLINEALLELNHHGKGP
                     VHINVPISEPLFQFTTPELPKVRVITRYQGLNVYDRKYDDLIERLNKYSKRMMIAGQMS
                     LIYLFEKKICKLLYKHFTWLSEHIGNRIVPGLPIKNFDAILYATPEEEKEKLVPELVIT
                     YGGHIVSKRLKEFLRKHPPKEHWHVSLDGEVADLFGSLTTVIEMDPFEFLEKIAYMLEN
                     RQIEYPKAWEYKSRNLPEPEFAYSEMAAIGGLIRSLPAESALHLGNSSTVRYAQLYTVP
                     ETVEVCCNRGTSGIEGSLSTAIGYASASQKLNFIVIGDLSFFYDMNALWNGNLHNNLRI
                     LLLNNGGGEIFQALPGFKMNERTHRYVTASHQTSAEGWATERGFSYSAVHNAEELAAAM
                     SAFTQTEQPSEHPLFMEVFTDKAEDVRLLKEYYHQLKNSSQAQNI"
     CDS             complement(12532..13629)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Chorismate_bind"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg15_117"
                     /sec_met_domain="Chorismate_bind (E-value: 1.5e-53,
                     bitscore: 174.9, seeds: 119, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIPRDSYEIIDTLIKQGRSFAIWRIPGEDRLHFRMQSAGSPCLLY
                     DIKDLNERSGFVIAPFQVTAERPIVLIQPDCFEIPSESDWDFSREKNEFPSNEIEIPSE
                     SEEKERYAYHFSLFTNPLLKGSQDKLVLSRSKTIWKDPSFSPGKAFFAAEERYIRSYVY
                     LCHTPETGTWMGGTPEILLSGEKGDWQTVALAGTQSLRDGKLPKSWDHKNWREQQLVAS
                     YIRRQLSTLGITPEEKGPYSARAGEVSHLKSDFFFSLPNPEKLGDVLQLLHPTPAVCGL
                     PKEEAYHFIIENEGYDRSYYSGFIGWLDPKGKTDLYVNLRCMNILPQTFTLYAGGGLLA
                     ASQLEDEWQETEDKLDTMRRIVGNL"
     CDS             complement(13626..14858)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: HBT"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg15_118"
                     /sec_met_domain="HBT (E-value: 1.7e-16, bitscore: 53.4,
                     seeds: 132, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKYKLLVLDVDGTLLNDKKEITPRTHAALLKAQQMGVHVVLASGR
                     PTNGVQPLAEALELNHYGGFILSYNGGQIINAQTGELMFEKRIDPAMIPYLNRKAKENG
                     FAIFTYHKDYILTDSPENKHVQEEAELNKMRIIGVENFPEAVDFAPCKCILTSDDENNL
                     VGLENHWKKRLDGVLEAFRSEDYFLEVAPHFINKGNTLAVLMEMLNITTEEVVAIGDGV
                     ADVSMLQLAGTGVAMGNARDSVKACADFTTLPNNMEGVAVAIEKAILATIKPTEVPLDQ
                     LNARAKHALMGNLGIQYTYASEDRVEATMPVDERTRQPFGILHGGATLALAETVAGLGS
                     MILAKPDEMVVGMQVSGSHMSSAHEGDTVRAVGTIIHKGRSSHVWNVDIFTSTDKLVSS
                     VRVINSILKKK"
ORIGIN
        1 aaatatgcca cggcctcgtc atgactgact tgtgtcgtgg tttttatttg cgggaatagc
       61 cgattgatcc gggtggttat cgtatcgcat aaattggggt aaaagttctc caaggctttc
      121 tcatagggtt gctcgttgaa gcagcaaagg cttccttcat tatagaataa atccattgcc
      181 aaccattgat ttttcattct ccactccgtc gagtcattca tttgtacccg taaatgtaaa
      241 ggggcgcttt tgatgaagag attcattgcg ccacgcttgc cttttttacg aatcagatct
      301 gttagttccg gaatgacatg tgcggggtat gtctgttgcc tttccaccgt ctctaccaat
      361 aatcttcggt tgtaggacgc tacgaatata ccctcgtggt agtaacaacc tagaaaatgc
      421 ttatcaacat caggataata tctaacagga acggaggttt cctctcgttg ctgggccgga
      481 aaagtgaaag agacgtccag ttgcttgaaa atacgctctg ccgtatgact atccataggg
      541 gcgtacaaga catccccttg tggataataa gcgattagga aagacgataa ttccagattt
      601 tgccgtatta aagaaaggaa aatagcgggc gtatgatctg agaacgcctt gcgtatattc
      661 tccatgggta gtatcatctt ctcgaataca ggaggacgat tgatggcaaa aattgccgtg
      721 gggcttggaa cgaccaaact atagggatct accgtagcga caaattgctc gtcgttcata
      781 tgcttgtaaa agtacctcac gcatacgatc gtacccagaa acaagacaaa aaatgccgtt
      841 atgtctttct tgctgatcct catgtttgct ttaggaagtg tttacaccaa ggctttaatc
      901 cgcattcctc acatttcggt ttccgggcga ggcaaacata tcttccatgc aatatcaacc
      961 agtgatgggc gatggggatc agttcttccg gaatgttctt cactagctcc ttttccgttt
     1021 ccaagggtgt cttgctatta ttggtcaagc cgatccggtt ggagacacgg aatacgtgcg
     1081 tatctaccgc catggctggc ttgtcatata caacggatgc gattacgttc gcagtttttc
     1141 ttcctacacc cggaagtttc tgtagctcgt caatatcgga gggaaccacg cctttgaagt
     1201 cctctatcag catcttcgcc atacctacca gatgtttagc cttattgttc gggtaagata
     1261 cgcttcgtat gtattcaaag acgacttccg gtgtgctagc tgccattacc tcgggagtag
     1321 ggaaagcctc gaacagggca ggagtgatca tattcactcg cttatccgtg cattgtgcgg
     1381 ataggattac cgctatcaat aattgatatg gatcgtcata atgtagttca gtctcggcta
     1441 ccggtacgtt ttccttaaac cagtttaata cgcctttata tctttcttct tttcgcattg
     1501 ttttttcggt ttctattttt cgcatcctaa aggtataact tttaaaagga atatacaagc
     1561 ggagatgtgc caaaaataag atactcccga attgtacgaa taaataaaaa agtaccgatc
     1621 tccttcttcc atctaagaga gaaagaaatc ggtacttttt tatttattat tccctaacga
     1681 tctggtggat atgtataggt tcttttccta ttgtggtgat ttctaaagaa gagaaatcct
     1741 cgaacatggt tttatttaat ttgatgtagc ctacgttccc ttgatagacg atgtttttct
     1801 caccatcttg agagaggccg gtgatagata ccaaattctc gttacttccg gagaggaaga
     1861 aagatacggc gttgatatca tcgcatttta tgtgaattat ttctcccgga ttcaagttct
     1921 tatacgtatc taggttcata tcgtacatca taagagcctc attgatttgc gggtcttgtt
     1981 tggttgtcgc cgtgaatcct agtacatata gctccatttg ctgatccgag ttatttcgca
     2041 tacggatata acgggctttc ggatcgatgg tgcggatcgt atccttggcg ttttccgtgg
     2101 agacatgggg gattaggctc cagctctttc cgtcagcaga ccactcgaat acccgtccgg
     2161 gttggttgct tttcggaaga ttgaaacaga aggattccgc ttctttctgg atttcccagc
     2221 cgatacccag atattgatta ggctgtacct tgactacctc gaataggggg acgtaaccga
     2281 ccgtattatc accctcggca caaggctggc tcttcaattg gtcgatattc gtgaatatgg
     2341 aagggatgct aaccttcacc tcgtccgggg cgataccgtc cgtagatagc aggttacgac
     2401 ctgtctgacg atataagtct acgatgaaag ggtgtaagac tttcgatccg actttcacgc
     2461 ctttaggctg tgccttctgg ttcagcgtgc ggtttatcag tttcatgcta tctagcaagg
     2521 cagatgtttc cagatagcgt tgccatgtat aagaccggtc tttctcatac caagcgtgcg
     2581 ccatatgcag agcacttgta ccggcttttc ctaagaactc gaattggata agccatggat
     2641 tgatttgttc gatcaggcgt ttattgggac tttggctgta gatcatgctc ggggaagccg
     2701 tgatttgagc gaataaggtt cccagaagat ttgcgctttg ctctgggaac gtgtttttct
     2761 tatatccggt aaggaatgtc tggataggag cgacatagtt agcagactct tcccggcggt
     2821 attgatgtcc gttcggaccc ggatcgcagt tatgctcgca gaaaatgcgg aaagccatgg
     2881 aggcctccgg cataataaag tcgcaagcgt ctttccatgc ctgtgtagga tcgtaattct
     2941 tgatattcca agtgtacatt ccaacgccga atatagcgac cttggaagcc tcggcgtatt
     3001 ccataggatt ggatacgaat ccggtcatgg tgccggcggc ttgcgtatct aggccgtagg
     3061 cgggtcccat caacaaatga tcttggcaat aatcgcttac ggggaagttc caccagatat
     3121 aggcgggacg acggatacgg ctgtttaccc actcgacgcc ttctttcgtg atatcggcta
     3181 cgacacggtc tccggtccac atgatttgga tagcggggtc gagttgggta ccgaggatat
     3241 ctagataatc ggtcttagcc catgagcggt tgtattcggt agggcacatg atcaggggct
     3301 gcacgtcatt tttcttggta ataaactcct tatggatgta attcaataag ccggcttgct
     3361 tttccgggcg ggctccctct ccggatatat catcgaagaa aacggcgaaa gagcgtacgc
     3421 ccaaatcgta cattttctcg aatttggaaa ggatattcat gctatctgtt aggttccatt
     3481 gaatgtcttg tcccgggtgg atggcccaaa cgaagtttac tttgttatgg gcggcctctt
     3541 tcgctagttc cttgatatgc tcggcttcct cggcgggata aggtttgcgc cagttggggg
     3601 agctgtgata aggatcatct ttcggaccat aaatataggt gttcagcttg atccttccgt
     3661 aaaagcggat ttgctcgata cggtcggcgt ggctccaagg ctgtccgtag aatccttcca
     3721 cggtaccccg gaataatacg tccggatagt ctttgatcga acagagaggc aggatctttt
     3781 taccctcgtc atatttagct aattgcttga gggtttgggc ggcgtaaaac aaggaattat
     3841 cgtctacgat cccgatcgtg ataccttttt tagtgatcgt cagcgtatag gcacccgagc
     3901 gttgcatttc cggagttttg tcttttagtt tcttgatctc taaagggaga gatttgccgg
     3961 atttagcgaa aggtagcgct tctttaagta gtttgaccgc atctgcgtcg ggattattta
     4021 taccccgtag ggtatatcca tggggcggtg cgtatgtttg gctggaaata gtcacctctt
     4081 ggggctcagg gaagattcct agggatagct tttggctatg cgttaggtta caaacgcata
     4141 gaaggagcat ggtggcgagt aaatacttta gtgtcttcat atacgatatg atttaatgtt
     4201 aacgttcgta aatgtatgaa ataattagac acagagcaca cggaatacac agatttccat
     4261 ggatagaaat gatatttcct tatatccgtg gatattcgtg tgttccgtgt gctccgtgtt
     4321 ttagatctta tagggagaat agcaataccc ggttatccgg atttgtccat tcatggatca
     4381 agctacgcac gtcgctatat tcggcgggag tgaactgttg cttgtccaac tcgatcgtac
     4441 gtactacctc gatcgtattt cctcttggtg tgatcgtgcg ggttacttta ccaaaaggct
     4501 tgcttatcac ttgctctttt gtggaggtct gcaacttcat gccctcggcg ggagtaaccg
     4561 tgtaggttac ctcttccttg atcagggagg ggagttcgaa taagttggaa cgcttgctgt
     4621 tcaaagcgct catgccccag ctatcgatac cgcctgttat agccggaagg gtacagatgg
     4681 cgaatccgtt ttgtgcttcg ttcttggaga cgctgacggc tttattctcc ttgatgatcg
     4741 taggctctgc ctgtagggcg atcgacgtgc cgttcaacgt gagtacctga tctaactcac
     4801 cccgggctgt taatgcggaa ggggcaaggc tgaccgccga aaggtatttg tctttccctg
     4861 cgacagtcgc ttttacggca agattcttga tcgtgcttaa tccacaagcg tctatatcca
     4921 gattccctgg atatacggcg actacttccg attgaatgcc ggcggcgttc aataagacgt
     4981 tcagaagctg ggtcttctcg gctaatgtac cgtaagcact gcgaagggcc gtatcgacat
     5041 cgcggatgga ataacccgta caagcgaggg ggatggcgca atatcccatg ttgttgacta
     5101 catggttccg gatggcgttc accttctctt cgtcgctagt agccttttcc gtgatataag
     5161 agccgaacgt tttgctctcg tagtttccgg aagtgttaaa acgcttattt agcgtagata
     5221 atgcctcctt gttggaacta tagcttgaag cgattaggcg gggaatcccg tcttggtttt
     5281 gaggaaggaa agcttcccgg gaagaggccg gcaggttacg taaagtccag cttacctctt
     5341 tagcgccgtt tcgggtggct tgggatgctt tcgcgtcgct acccaataat tgccaagcga
     5401 gcggactgtt ttccggtacg gagatagaga ccttgcattc cttcacggga gaagtctctt
     5461 gtagtcgctc gttgatatcc atagccggat agtagcccgg ttttgtgata atagagtaat
     5521 ccaagtaaat cgtggcccca agttctaggc cagtgtgtac cacgaccatt tccttgagtt
     5581 ggttataggc cggagcgtcg gcggcgaaac ggggtaggac ctctacaaag gcgttatcgg
     5641 gtgtctttac gatcgtaccg tctttctgcc ttgtatagga tgagtggatc ttcagtgttt
     5701 ggaaatcggg attgtagacg ataaaactct cgccatacgt gctattcatc gcagtgtgcg
     5761 tgaagagcgt caattccatg gaggatcggt attcttggct accgtcggca tgcaaggtcc
     5821 aagctttcga taccttcccg tactcagcct ccgatgcggc gaatgaagta accgtcatcg
     5881 ctaacaagcc taggagaaga atcagtttat aggttatctt aatcattgtc tttctgtttt
     5941 tatttcttga taatcaaata gtcaccataa ctcttataag cgttcacggc ggaacggaaa
     6001 cctttccagt cggctgcgtc gtagacacgc ttcttcaacg ctagcttctg gcgcaagacg
     6061 atgttctgat tgccttcctg cgaaagggaa ccttcgaaat cggccgcatt gctttgcagg
     6121 acgtcattct tcggggcgtt caagagggta tagcccttgg ggaggcggat ggtctcatct
     6181 tgttctacca aacgggagca agcatccttg aatccatacg cacggttttc cggtttcgta
     6241 tcgatacgca agaaactctt cacttgattg tagaggttat tcatgactag cggcttgata
     6301 agcatctggt ctccggcgat gatcgcgtaa tcggggatct cataagagaa cgtgatcttg
     6361 ataggggccg cttgatagtt cttcgggtcc ttaccgtaat ctacacgaag cagtttggcg
     6421 ttgggggata cggccagcaa ttgcttctcc atcgtgttct gccagtcgga ttgccatccg
     6481 gtggtgaaga tgcggcggat attgctgtcg gattgtccct cggcggtgat cgtgaattgt
     6541 ccgcggagcg tgcctttctc gtctaggcgg ttgtcggcgt ggatgcggac gtagtggttc
     6601 tccggggcgg agacaggggt taagcggagg tcggagcctt cgggcacacc cgggaggtag
     6661 ttctgctgtt gctcggcgct actccataat tcccggcaga aaggaaccca agtcgggtcg
     6721 agaggcatat acgtgccgct agccagtttt accaccgcca cgcaatggtt gaaatggtcg
     6781 gcggggatgc tttctacacg gcttcccgcc atggtcatcg ccgggtaagc ctcgaagccg
     6841 gccatgcgga ggaaggcgat caacgtaccg gcgatatcct tgcagacacc gcaacgatcg
     6901 gtataattca ttttcaggtt gtgaagcgtg aaaccctcgc ctttacccat cgagattccg
     6961 gagtaacgga tgttatcggc cacccagtgg gtcagcacgg ctatcttctc catttccgtt
     7021 ttcttgcctt tgatcagctc gtctaccttt ttctgggctt ccgggatcgc agtaaagctt
     7081 ccgtaatcct cgttaacctt attgaaccaa agggatttat cctcccagcg gggagtactg
     7141 gacatcatga gcttcggggc agcgtcgaat aggtctacca tgttcggttc cttggcgaaa
     7201 ggaaggatat cgtcggaggc gaaggtatat actttccgtc tgtcctcgta tcgcatcgaa
     7261 gaggtacatt cgccttggta gaactggaat tgcaactctt tctccatcgg catggatacc
     7321 cggtacacct tgcgcacggt aggctcggta gcccagaagg ggacgatatc gtaaaactgt
     7381 cctcgcatag gagggatgaa acgctcgtcg tcgtcacccg ccgtcagcaa ggcgtaggtg
     7441 aaacctttct tggcgatctc gtactccacg atatctcccg gttgcaagcg gcccacttcc
     7501 agcatgatct gccgggcgcc ccagtagatg gcacgtgcgg gggcggcgta gtcgcaagct
     7561 tgggttacgt cgagattgat cacgtcgccg ttcgcacggt agatcgtggc gtaacgaaac
     7621 tcggcgtgcg ccgtcagcgg gtcgtaatcg tatttgatga tacggttggc gacggctcct
     7681 ttggaagtct gtaccttaaa agccttgcat acggcgaaag cccccgagcc ggtaggttgt
     7741 accgtaacgg cggtgctatc cagcaaggtg acgcagtcgt atcctgcata ggcttgcgat
     7801 ttctccaagg taggatcttg cgggtatcgg caagaatcct gcccgtacat aggcgataag
     7861 gccaataggg agaccgcagt gattgttaga attcttttca tgtttatagt gtttttgtaa
     7921 tgatatttct cgctagctcc cggcaggcgg cacggtcgat cttgccgctt ccggtttggg
     7981 ggatctcgct tacctttatg atgtgcctcg gacggaggta cttgggcagg ttggcgagaa
     8041 cctctgttag catctcacct cgtaggtttg aggcaagcag tagcacgacc gcctctccca
     8101 accgagggtc gggggtggcg gtgatggcat aggggcggtc gaggtagggc cgtagccgct
     8161 cttccacctc ctcgatctgg atcttgatac ctccgctatt gatgatatta tctttccttc
     8221 cgataatggc gaaactcccg tccggcagca ggcgggcgac atcgttcgtc accagccgct
     8281 cgtcgcaaac caatggggcg tctattacca aggtattgtc cggtgacaag gataacgtca
     8341 ccgaggggaa gggatggtaa tagggcgagg cttccggccc gttcaaccgg cgcagggcga
     8401 cgtgagacag cgtctccgtc attccgtagg tggaataaac cgtgtttggc atctgccgta
     8461 tctcctgttc caaggccgcg tcgatcgccc cgccgccgat gatcaagata tccgtttgct
     8521 ccagccgttt acgttcctcg ggtactcgca acgtattgta aacctgcaaa ggaatcatgg
     8581 cggcaaagcg caggggcgta tccccccaat ccgccaacgg gtgtccggag ggttcgcaca
     8641 cctccagatc cagtccggcg tatagggagc ggaccaccat catctttccg gctatatagc
     8701 gtaggggcat acataacaag gccttgtcgc ccttcttaag ccccagataa tcgcaggtaa
     8761 gccgggcgct gttcagcatc cggtccttgc gtactcgcat ccgcttgggc gtaccggtgg
     8821 agccagaggt ctggacttcc agaaaagggg agggatcgtg ccattcagct aagaatgcct
     8881 gtaaatcttc ttgtatcggc ataggtcaaa ggtcgttggt gaaccagatg gtgtctcctt
     8941 ttcgttggat caacttatgt ttatcgtcct tgaaaatctc gccggttccc agaccttgcg
     9001 gtagcgggtt acctagcgtg gcgcaccatt gggcgatagc gttcagtccg atttgcgatt
     9061 ccagagcgga ggtgacccac catttaggtt gttcaggggt actccctaag atagtttccg
     9121 ctaagtgaac ccattccgtg catccggcga tacctccgtg gagggaaggc tttaatataa
     9181 tgtattgggg atggatcgtt tccaacaacc gccgtttctc gtccggggcg ttacagccga
     9241 tcagttcctc gtcgagagcg atgggaaggg gtgactctgc cgcaaggcgt gccatctctt
     9301 ccaactgccc ggcacggata ggctgctcga tggaatgcaa gtccatctcg gcgagccgct
     9361 tcagtttgtc catcgcctcc gagggtgtga aagcgccgtt ggcatctacc cgaagctcta
     9421 tttccttggc agagaaatgc gcacggatgt gtttcaataa agagagttcc cggtcgaaat
     9481 cgatagcgcc gatcttcagc ttgacgcagc ggaagccctc cttcatcttt tcctctacct
     9541 gttccagcat gtacttataa tcgcccatcc agatcagtcc gttgatgggg atgcccgcct
     9601 gcccctgcga gaagggcgtg tcgtaatgcc gccaaccgcc ctgttcataa tggcgcatgg
     9661 ccgtctccag cccgaaaagg atggatgggt aatggcgcaa agattcggtg tcaacatatc
     9721 ccttctgttc cagatcgagg caagccttgg ataacgtgat ctcgtaatcc actccataat
     9781 cgcaactgag atccggcagg ggggcacatt ctccgatacc aataaccgag ggttcgtctt
     9841 ccttacggat tcggacctcc cacaatttcc gggtcgtgta aacaccccgt gaggttcctg
     9901 ccggtcgctt gaaagtcaag caccggggaa ccacctcaat cctatataac ctctccttta
     9961 ccattcattc ttaattattc attattcatt ctcaatcccc ctacgggaat ttcgggtaat
    10021 cctcgaagcg gggacggcgt ttctccaaga atgccttacc gccttcctgc gcctcgtccg
    10081 tcatatagta aagcatggta gcgtctccgg ccaactcctg tataccggcc tgtccgtcca
    10141 actcggcgtt taagcccgcc ttgatcatgc gcaaagccaa cgggctaagc aacatcatct
    10201 cctcggccca ttgaacgtac tcgtcctcta atttatccaa ggggactacc ttatttacca
    10261 gacccatatc caaagcctcc tgcgcattgt acttgcggca taggaaccag atctcacggg
    10321 cctttttctg tccgaccaca cgggcgaggt aagaagagcc gaacccggcg tcgaagctac
    10381 ccacacgagg accagtctgt ccgaagatag cgttctcgga agcgatcgta aggtcgcaaa
    10441 ccacgtgcaa tacgtgtccg ccgccgatag cgaaaccatt cacggccgcg atgacgggtt
    10501 tcgggagaga gcggatctgc ttttgtacgt ccaatacgtt caagcgaggt acgccgtctt
    10561 tacccacgta gccgccacgt cctttcacgt tcatatcgcc tcccgcgcaa aaggccgtat
    10621 ctccggctcc tgtcagaacg actacgttaa tgtccgggcg ttcccggcag atgtaaaagg
    10681 cgtcgctcat ctccgtggtc gtagtcgggg taaaagcgtt gcgataccgt tcccggttga
    10741 tcgtaatgcg ggcgatgccg ttgtagaaat caaataagat ctcctcatat tccttgatgg
    10801 ttgtccattc tcttttcgtt tccatatatt atatgttttg tgcttgggat gaatttttta
    10861 gttgatgata atattccttg agcaatcgta cgtcttccgc tttgtccgtg aaaacctcca
    10921 tgaatagggg atgttcgctc ggttgctccg tttgggtaaa ggcgctcatc gccgctgcca
    10981 actcctcggc attatggaca gcggagtagg agaatcccct ttccgtggcc catccctccg
    11041 ctgaggtctg gtgggaggcg gtaacgtaac ggtgcgtacg ctcgttcatc ttgaatcccg
    11101 gcaaggcttg gaagatctcg ccacctccgt tgttcaagag caggatgcga aggttattgt
    11161 gcaagttacc gttccacaac gcattcatat catagaagaa actaagatcg cctataacga
    11221 taaagtttag tttttgcgag gccgaggcgt atccgatggc cgtagacaag gagccttcga
    11281 tcccgctcgt acctcggtta caacaaacct caaccgtctc gggtacggtg tacaattgcg
    11341 cgtaacgtac ggtggagcta ttccccagat gcaaggccga ttcagccgga agcgagcgta
    11401 tcaaaccacc gatcgccgcc atttcggagt aagcgaactc cggctccggc aggttccggg
    11461 atttgtattc ccaagccttc ggatattcaa tctgcctatt ctccagcata taagcgattt
    11521 tctccagaaa ctcgaaaggg tccatctcga tcaccgtggt caggctaccg aataaatccg
    11581 ctacctctcc atccaatgag acatgccaat gctccttagg cgggtgtttc cgcaaaaact
    11641 ctttcagccg cttggagaca atatggccgc cgtaggtgat tacgagctcg ggaactagct
    11701 tctctttttc ctcctccggg gtagcgtaca ggatagcgtc gaaattcttg atcggtaatc
    11761 ccggtacgat acggttgccg atgtgctcgg agagccaagt gaaatgcttg tatagtaact
    11821 tgcatatttt cttctcgaag agatagatca agctcatttg tcccgctatc atcatccgct
    11881 tgctatattt gttcaagcgc tcgatcaggt catcatattt ccggtcgtac acgttcaagc
    11941 cttgataacg ggtgattacc cgtaccttcg gcaattcggg tgtcgtgaac tgaaataaag
    12001 gctcggagat cggaacgttg atatgcaccg gtcctttgcc gtgatggttc agttccaaca
    12061 acgcctcgtt gatcaatcga ttgcaatacc attcatcttg atccgtatgt atttccggta
    12121 gctgcaccga cttctttacc agcgagccga acaccccggg ttgcggcaag gtctgtccgt
    12181 ccatttgccc gatccatgcg gcggggcggt cggcggatat cacgacaagc ggaactttct
    12241 gatagaaagc ctccgctacc gccggatgta tattcagcaa ggccgtgccc gaggtacagc
    12301 aaacagccgc cggcttacct ccgtgcaacg ctagccctac ggcaaagaat cccgcgcttc
    12361 gttcatccgt cacggaatgg caattgaaga acgaatggtt tgccaatgtg tgcacaatcg
    12421 gagagttccg gcttcccgga catagcacga tattacttac gccgtgctct atcagcaagg
    12481 ctaccaattg aaggatgttc tttttatcgc tatacattat atgatataaa attataaatt
    12541 acccactatt ctccgcattg tatctaattt atcctctgtc tcctgccact catcctctag
    12601 ctgcgaggcc gccaacagac cgcctccggc atacagcgta aaggtttggg ggaggatatt
    12661 catgcaacgg aggtttacgt acagatctgt tttgcctttg ggatccagcc aaccgatgaa
    12721 accggagtaa tagctacgat cgtacccctc attttcgatg atgaaatgat aagcctcctc
    12781 cttgggaaga ccgcagacgg ctggagtagg gtgtaatagt tgaaggacat cacccagctt
    12841 ctcgggattc ggcaaggaga agaagaaatc acttttcaaa tgagaaacct ctccggcccg
    12901 ggctgaataa ggccccttct cctcgggagt aatacccaag gtggacagct ggcggcgtat
    12961 ataggaggcg actaattgct gttctctcca attcttatgg tcccagcttt tcggtaattt
    13021 cccgtctcgt aaggattggg ttccggccaa agctaccgtt tgccagtcac ctttctcgcc
    13081 ggataacaag atttccggtg tcccacccat ccaagttccg gtttccgggg tatggcaaag
    13141 gtagacatag gagcggatat atcgttcttc cgcggcgaag aatgccttgc cgggtgagaa
    13201 agagggatct ttccagatcg ttttgctacg ggataggact agtttatctt ggcttccttt
    13261 tagcaaaggg ttggtaaaca gggagaaatg gtaagcgtat cgttccttct cctcggattc
    13321 ggacgggatt tcgatttcat tcgaagggaa ttcgtttttc tctcgagaga aatcccaatc
    13381 ggattcggag gggatttcaa agcaatccgg ttggattaaa acgataggtc gttccgctgt
    13441 cacctgaaac ggagcgatta caaaaccgct ccgttcattt aagtctttta tgtcgtataa
    13501 taggcaagga gagccggcgc tttgcatcct gaaatggagc ctatcctcac cgggaatacg
    13561 ccaaatagcg aaactccggc cttgcttgat caacgtgtct attatttcgt aagaatctct
    13621 tggaatcatt tcttctttag tatactattg attacccgta cagaggaaac cagtttgtcg
    13681 gtagaggtga atatgtctac gttccacaca tgggatgaac ggcctttgtg gataatcgtc
    13741 ccgacggcac gtaccgtgtc tccctcgtgg gcggacgaca tatggctgcc gctaacttgc
    13801 atgccgacta ccatctcgtc cggtttcgcc agaatcatgg aacctagtcc ggccacggtc
    13861 tccgccaaag ccagcgtagc gcctccgtgc aagataccga aaggctggcg ggtccgttcg
    13921 tctacaggca tggtcgcttc cacacgatcc tctgacgcat aggtatattg aatgcctaga
    13981 ttacccatta aagcatgttt ggcccgtgcg tttagttgat ctaacggaac ctctgtgggt
    14041 ttgatcgtgg caaggatcgc tttctcgatc gctaccgcca caccttccat attattgggt
    14101 aaggtcgtga aatcggcaca agcctttacg gaatcgcgtg cgttacccat cgccacgccg
    14161 gtaccggcta attgaagcat ggatacgtcg gccacgccat caccgatagc gacaacctct
    14221 tcggtcgtga tattcagcat ctccatcaat accgccaacg tatttccctt attgatgaaa
    14281 tgaggagcta cctccaagaa atagtcctcg gagcggaaag cttccaatac cccgtccaaa
    14341 cgtttcttcc aatgattttc gagacccact agattgttct cgtcatcgct ggtaagaata
    14401 cacttacagg gtgcgaaatc caccgcttcc gggaaattct ccacaccgat gatgcgcatc
    14461 ttattgagtt cggcctcctc ttggacatgc ttgttttccg ggctatcggt caggatatag
    14521 tccttgtgat acgtgaagat agcaaaacca ttttccttcg ccttccggtt taaataagga
    14581 atcatggccg gatcgattcg tttctcgaac atcaattctc cggtctgggc attgatgatc
    14641 tgacctccgt tataagataa tatgaaacca ccgtaatgat tcaattcaag agcctccgcc
    14701 aagggttgaa ccccgttggt gggtcggccg gatgccaata caacatgaac tcccatctgc
    14761 tgagccttta acaaggcggc atgggtccgg ggagttatct ctttcttgtc gttaagcaac
    14821 gtcccatcta cgtctaagac taataatttg tacttcatgg cgtcttattt ttatggttta
    14881 gaatacaaat atactataaa tctctggaat aacctcgaaa aacgggagaa atgacgctaa
    14941 acgact
//
