LOCUS       c00009_gnlPro..        14441 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|LGNFGKJK_9.
ACCESSION   c00009_gnlPro..
VERSION     c00009_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-07 06:00:26
            Original ID  :: gnl|Prokka|LGNFGKJK_9
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14441
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14441
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[761:4441]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      762..4441
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..14441
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14441
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             complement(2..754)
                     /locus_tag="ctg9_1"
                     /transl_table=11
                     /translation="VVCELPQQKRIMDKDKSKIGEFHFVTEPYLLDFRGRVTIPMIGNY
                     LIHVASSHAAERGFGFNDMSERHTAWVLSRLAIEMIEYPAMSEPITLYTWVDEVGRLFT
                     SRCFELVDGNGKTFGYARSIWAAIDVETRRPTLLDIARLSAYVTDRPCPIEKPGKIAAV
                     ENETEGVPYFIKYSDLDINGHLNSIKYMEHLLDLFDLDLFKTKDIKRFEIAYQSEGKYG
                     MKLMLYKREADNGKYDMAICNEGKAICRA"
     CDS             complement(762..1313)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg9_2"
                     /sec_met_domain="ALS_ss_C (E-value: 1.8e-17, bitscore:
                     54.7, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTKKLYTVIIFSENTVGLLNQITIIFTRRQLNIETLSVSPSAIQ
                     GIHKFTITTFADEDMIDKVVKQIDKRVDILKAYYNTDEDLVFQEIALYKLSTELFIKMG
                     TVEDLIRKYNARILEMNETCVVLEKSGHYDETQALFRELSKTIGVLQFIRSGRVAITKS
                     RVERLSDMLAEMERKLQEKK"
     CDS             complement(1326..2510)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg9_3"
                     /sec_met_domain="TPP_enzyme_C (E-value: 2.3e-51, bitscore:
                     164.8, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VEYEYKKVDYIRSYQPEPDINQDRIKVAAALINKAEKPFCLVGQG
                     VLLGGAEEELKAFLLKNDIPAGSTVLGLSALPSDFPLNKGMLGMHGNVGPNRKTNECDV
                     LIAIGMRFDDRVTGDLKTYAKQAKVIHLDIDNSEIGKNVPVDVKVLGNAKHTIPMITAL
                     LEERKRPEWNAEFELDAQEEYEKVIEKELYPMNGSLKMGEVVRKVSEATGNDAVLVTDV
                     GQNQMMGVRYFKYKRTRSVVTSGGLGTMGFGLPAAMGAKFGAPDRTVCFFTGDGGMQMT
                     IQELGTIMQEKLDVKIIILNNNFLGMVRQWQELFFHERYSNTIMENPDFVAIAKAYGIA
                     GRTVEKREELDEAIAEMLNHNGAFVLVANVETCGMVYPMVPAGGSVTNMILGDK"
     CDS             2868..2984
                     /locus_tag="ctg9_4"
                     /transl_table=11
                     /translation="MTHQYMLQFIPVIVQTIVNRNRLPAGITENRIYSFSYQ"
     CDS             complement(3050..4441)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ILVD_EDD"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg9_5"
                     /sec_met_domain="ILVD_EDD (E-value: 3e-157, bitscore:
                     515.5, seeds: 918, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEAGELDNRHLDLIDAMIESADTSVSDERIAQVERNACPGCGCCS
                     GMFTANSMNCLNEAIGLALPGNGTIVATHVGRTQLFRDAARQIVENAYKYYRDGDESVL
                     PRSIATRQAFLNAMSLDIAMGGSTNTVLHLLAIAQEAEADFTMDDIDMLSRKTPCLCKV
                     APNTHTYHVQDVNRAGGIMGIMNELLKNGLVDGNVKRVDGMTLAEAVDKFAITSPNVTD
                     EAVKKYKSAPAHRFSIRMGSQETYYKELDTDRAAGCIRDIEHAYSKDGGLAVLKGNIAL
                     DGCVVKTAGVDESIWKFAGPAKVFDSQDAACEGILGGKVVSGDVVVITHEGPKGGPGMQ
                     EMLYPTSYIKSRHLGKECALITDGRFSGGTSGLSIGHISPEAAAGGAIGLVKDGDIIEI
                     DIPERTINVKVSDEELAERRKAEEARGTKAFTPPHRQRVVSKALRAYGKMVSSADKGGV
                     RVVED"
     CDS             4550..4759
                     /locus_tag="ctg9_6"
                     /transl_table=11
                     /translation="VGIHHILDAVRNNITRRKRIEHSVVSHSDTIVNGNRIEFGSKATQ
                     LFNLRFYLLPDLVQMDMAGYKLGK"
     CDS             4767..4988
                     /locus_tag="ctg9_7"
                     /transl_table=11
                     /translation="MAIIGLPNCSSFRPLARHKARAPAMRLPSVLYELLNGFFIILFVV
                     FERLTNRPYFLILNIIILKKPFSVWRKT"
     CDS             5722..6972
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg9_8"
                     /sec_met_domain="Aminotran_1_2 (E-value: 1.6e-41, bitscore:
                     133.9, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSESKQFLNIIRIFDPDQQTELIEIMKQYNFDEIIERRGTNCVKY
                     DLLKKDFGNENLVPLWVADMDFRTPDFIVNAIKKRLEHEIFGYTFDSDSYYNSIIEWVH
                     YKHNWKIQREWLSYIPGIVKGIGFVLQCFTKPGDKVIIQPPVYHPFRIVPENMHREVVY
                     NPLKTVDDIYEMDFENLESVIDEHCKVLILCNPHNPGGVVWKKDTLVKLAEVCAKHNIL
                     VISDEIHAEMAYPQYTHHPFATVSETAANCSITFMAPSKTFNIAGIVTSYSIIPNAEIR
                     EKFYSFMEAGEFNAGTVFAYTATEAAYTYGAEWLQQMRMYITENVRFVDEYCKSKLPKI
                     KVYPPQASFLVWLDCRDLKLSQPELVSLFQDKAGLLLNDGSMFGPGGEGHMRLNIGCPR
                     SVLSSALDALKKAIDKK"
     CDS             complement(7064..7516)
                     /locus_tag="ctg9_9"
                     /transl_table=11
                     /translation="VYIDNFTIEMQCFAGQRMVEVHNDNIFFYFQDRTVHTIAVRIHHR
                     YRVAFFDHFRVELAVYLENILRKIQYVFLHIFAVCISRSYGKIKFVAYFQSFQSVFKSG
                     EHSACTKDEFQRCFSCCSFHQFAFFAFAYVQIVSNCNELICCNFHL"
     CDS             complement(7545..7838)
                     /locus_tag="ctg9_10"
                     /transl_table=11
                     /translation="VILDCPGLRRFSSLWINAVSSSIPAGHPSITPPIPGPCDSPKEVS
                     LYMFPNVFTLAKIVNCQFFNGIRHIRIHFRGYGRHNRFHSRHIHNRIHLPEL"
     CDS             complement(7777..8130)
                     /locus_tag="ctg9_11"
                     /transl_table=11
                     /translation="LYPDTFLAKNQFGNCSGYATGDRFTCRRTSTSARVADSVFGLVGV
                     ICMGRTINILHIIVVRRVLVLVPDNETDRSPCRFSFVNTGKELYFVVFLAWGCDFGLSR
                     FTAVQFTLDKCRI"
     CDS             complement(8170..8376)
                     /locus_tag="ctg9_12"
                     /transl_table=11
                     /translation="MSQCRMQLSEYRFAQTNGNSLCYAGDYAADRISFGFHFGDQSLHF
                     FGGRRVRTTYGRIFRLVQVVIRV"
     CDS             8380..8748
                     /locus_tag="ctg9_13"
                     /transl_table=11
                     /translation="MLTINAVKGFEYGDGFEAALYRGSERNDRFFNDNGHINTHTNHSG
                     GIQGGISNGQDIYFRVAFKSVATILMEQETVNTEGEDTILKARGRHDPCVLPRAVPIVE
                     SMAAMTLLDFLLMQKIRN"
     CDS             complement(8817..9290)
                     /locus_tag="ctg9_14"
                     /transl_table=11
                     /translation="MKIALIVIGKTDAGYFVEAINEYKNRLVHYIPFEMEVIPDIKNVK
                     NLSESQQKEREGDLILKALQPGDYLVLLDEKGKEFTSVQFSTYIERKTHTVPKRLVFVV
                     GGPYGFSDAVYKAAAEKISLSKMTFSHQMIRLVFIEQLYRAMTILNNEPYHHE"
     CDS             complement(9359..9721)
                     /locus_tag="ctg9_15"
                     /transl_table=11
                     /translation="LFPSARYVTFTRYSPDEVGSLATKKPFSFLSAWWTTVNPVGLFPP
                     KKVFSIETASFALHFLDEPGRAISTSLSIDPLSDEALPPLKAFDIGSISAAITLRTERT
                     NANVRNNRFISFFLFL"
     CDS             9774..10631
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) QRPTase_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) QRPTase_N"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg9_16"
                     /sec_met_domain="QRPTase_C (E-value: 2.6e-61, bitscore:
                     197.5, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="QRPTase_N (E-value: 3.9e-28, bitscore:
                     88.7, seeds: 125, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNVQETKEQLIAELIRLAFAEDIGDGDHTTLCCIPATEMGKSQLI
                     VKEDGVLAGVEMAERIFHTFDPELKMTTFIHDGAEVKKGDIAFVVEGKVQSLLQTERLM
                     LNVMQRMSGIATTTRKYVKALEGTKTRVLDTRKTTPGLRMVEKEAVKIGGGVNHRIGLF
                     DMILLKDNHVDFAGGIEAAITRCHQYLKEKNKDLKIEIEVRNFDELQEAMRVGGIDRIM
                     LDNFNIENTKKAVEMVAGRYELESSGGITFATLRDYAECGVDYISVGALTHSVKGLDMS
                     FKAC"
     CDS             complement(10659..11234)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Hexapep"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Hexapep_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg9_17"
                     /sec_met_domain="Hexapep (E-value: 9.2e-15, bitscore: 45.2,
                     seeds: 216, tool: rule-based-clusters)"
                     /sec_met_domain="Hexapep_2 (E-value: 3.1e-10, bitscore:
                     31.0, seeds: 55, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="METYKAHETAVIDPGCTIGDGTHIWHFSHIMPGCTIGRNCNIGQN
                     VVISPLVVLGNNVKVQNNVSVYTGVTCGDDVFLGPSCVFTNVVNPRSAVSRKDQYLKTY
                     VGKGASIGANATIVCGHTIGEYAMIGAGAVVTKDIPPYALVVGNPSRQIGWVSEYGHRL
                     SFNEKGIATCPESNQQYLLEGGVVTRIS"
     CDS             complement(11235..11702)
                     /locus_tag="ctg9_18"
                     /transl_table=11
                     /translation="LAEGESVGVISEAGCPAVADPGADVVAIAQRKGYKVVPLVGPSSI
                     LMSVMGSGFNGQSFAFHGYLPIDASQRTNAIKKLEGRIYSENQTQLFIETPYRNNKLAE
                     ELIRTCRPSTKLCIASNITCEDEYIHTRPVKEWAGKVPDLSKKPTIFLIYK"
     CDS             11739..11960
                     /locus_tag="ctg9_19"
                     /transl_table=11
                     /translation="MLVQFIKDKIVNHDRRLCLFQETACRTYIFDNEMTDGKDNLPVVF
                     GKDPAMFDVAKRDRDEIESGHEFMIYDL"
     CDS             12070..13476
                     /locus_tag="ctg9_20"
                     /transl_table=11
                     /translation="MALPIDFITRTRALLGNEFDSFEAALQADVPVSIRINEKKGTPAP
                     STAGAPCERVAWCETGYYLPERLSFTFDPLFHAGAYYVQEASSMFLEQAIRSHVKTPVR
                     CLDLCAAPGGKSTHLAACLPEGSLLVSNEVIRSRSHILAENIAKWGNPNCIVTNNDPKE
                     IGCLTHFFDVIVADVPCSGEGMFRKDTDSTGEWSVANVELCAGRGRRIIHDVWNALKPG
                     GLLIYSTCTYNMEEDEENIHYITEELGAETLPIPIKDEWQITGPLKYNHPVYRFFPHKT
                     KGEGFFLAALRKADGETEEIRFKNKNKKEKGKTVPAVPEAARAYLLDTTSFTPEWSGST
                     LWMLPEPVRDVYPLLREHLRILSAGICIGETKGKDFIPAEELALSTALCPDAFPVADLD
                     WDDAIRYLKKEALLLPAGTEKGYVLVRYKKFPLGFTKHLGNRANNLYPQEWRIRTGYVP
                     EKVKTFEMKV"
ORIGIN
        1 cagcacggca aatcgctttg ccttcattac agatcgccat atcatatttt ccgttatcag
       61 cctccctctt gtacaacatg agtttcatcc catatttgcc ttcagactgg taggcaattt
      121 cgaaacgttt gatatctttt gtcttgaaca ggtcaagatc aaacaggtct agaagatgtt
      181 ccatatactt gatactgttc aggtggccgt tgatatcaag gtcgctgtac ttaatgaaat
      241 aaggaacccc ttccgtctca ttctccacag ccgcaatctt tcccggcttt tctatcgggc
      301 aggggcgatc cgtgacataa gcgctcaacc tggcgatatc caacaaggtc ggccggcgtg
      361 tttccacatc gatagccgcc caaatagaac gggcgtaacc gaatgtctta ccgttgccat
      421 ccaccagttc gaaacaacgg ctggtaaaga gacggccgac ttcatccacc caggtataaa
      481 gagttatagg ttcggacatg gctggatatt cgatcatttc gatcgccaga cgggaaagaa
      541 cccaagccgt atgccgttct gacatatcgt tgaaaccgaa tccgcgttca gcagcatggc
      601 tggatgcgac atgtatcaga tagtttccga tcatcggtat cgttacacgt ccacgaaaat
      661 ccaacaggta cggttccgtg acgaaatgaa attcccctat tttgctttta tctttatcca
      721 tgattctttt ctgttggggc agttcgcaaa ccacccgtac gttatttttt ttcctgcaac
      781 ttacgttcca tttcggccaa catatcgctc aaacgctcga cacggctttt tgtgatcgca
      841 acgcgaccgg aacggatgaa ctgcaagaca ccgatcgttt tgctcaactc cctgaaaagg
      901 gcttgcgtct catcgtaatg accactcttt tcgagaacga cacacgtttc gttcatttcc
      961 agaatacggg cgttatattt gcgaatcaga tcctcgaccg tccccatctt gataaacagc
     1021 tcggtgctca gcttataaag ggcgatctcc tggaaaacca gatcttcatc cgtattgtag
     1081 taagccttca agatatccac ccgtttgtcg atctgcttca caaccttgtc gatcatatct
     1141 tcatcagcaa atgtcgtgat cgtaaattta tgtataccct gtatggcgga aggtgaaacg
     1201 gaaagcgtct cgatgttcaa ctgccgacgt gtaaagataa tcgtaatctg gttcagaaga
     1261 cctactgtat tctctgaaaa gataataacg gtatataatt tttttgttgt catagcttca
     1321 cctccttact tatctcctaa tatcatgttc gttacgcttc ctccagcagg caccatcgga
     1381 tataccatac cacacgtttc cacattggcg accaacacaa acgctccgtt atggttcaac
     1441 atctcggcaa tagcctcatc cagttcctcc cgtttttcaa cggtgcggcc agcgataccg
     1501 tacgctttcg cgatcgccac gaaatccggg ttctccataa tcgtattcga ataacgttcg
     1561 tggaagaaca actcctgcca ctgacgtacc attcctaaga aattattatt gaggatgatg
     1621 attttcacat ccagtttttc ctgcataatg gttcccaact cctgaatcgt catctgcatc
     1681 ccaccgtcac cggtaaagaa gcagaccgta cggtcaggtg caccgaactt ggctcccata
     1741 gcagcgggaa ggccaaagcc catcgtcccc agaccacctg aagtaaccac gctacgagtg
     1801 cgtttatatt tgaaatagcg gacacccatc atctggttct gtccgacatc cgtaactaaa
     1861 acagcatcgt ttccggtcgc ctcggacact tttcgaacga cttcacccat tttcaaagat
     1921 ccgttcatcg gatacaactc cttctcgatc accttttcat actcttcctg tgcatccagc
     1981 tcaaactcag cattccactc cggacgtttc cgttcttcca acaacgcagt tatcatcgga
     2041 atggtatgtt tggcatttcc gagaaccttc acatcgaccg gtacattctt cccgatctcc
     2101 gagttgtcga tatccaaatg gatcactttc gcctgcttgg cgtatgtctt caaatcgcct
     2161 gtaacacgat cgtcgaaacg cataccgatg gcgatcaaca cgtcacattc attggtcttc
     2221 ctgttcggac cgacattgcc gtgcataccc aacataccct tattcaaagg aaaatcggaa
     2281 ggcaacgccg atagaccgag aacagtcgaa ccggcaggaa tgtcattctt caacaggaat
     2341 gctttcagct cctcttcagc acctcccaac agaacaccct gtccgaccag gcagaacggt
     2401 ttctccgctt tattgatcaa cgcggcagcc actttaatcc gatcctggtt gatatccggt
     2461 tccggctgat agctacggat atagtctact ttcttatatt catactccac aaatccaacc
     2521 tgagcatcct ttgccaaatc gagtacaaca ggccccggcc gtccggtaga agcgatataa
     2581 aaagcacgtg aaacagccca cgctatctct tccggcttgc gaatctggta cgcccatttg
     2641 gtgatcggtt gcgtaatgcc gatcacatcg acttcctgga aagcatctgt tccaagcaat
     2701 ggagaaggga cctgtccggc tatgaccacc ataggagtgc tgtccatcag tgcatcggca
     2761 atgccggtga tggtatttgt tgcgccgggt cctgaagtaa ccaacgtcac ccctacttta
     2821 ccggatacac gggcataccc ttgtgcagca tgcgtcgccc cttgttcatg acgcaccaat
     2881 acatgcttca atttatccct gtaatcgtac aaactatcgt aaataggaat cgcttgcccg
     2941 ccgggataac cgaaaatcgt atctactcct tcagctatca gtgacttcag caaagcttcc
     3001 gaaccggtta tcttctgttt ctccatatct ctttatttta gtcttgtgtt taatcttcta
     3061 ctactctcac tccaccctta tcggccgaac tgaccatctt accgtaagct ctcaaggctt
     3121 ttgagacgac acgctggcga tgaggcggcg taaaggcttt tgtgccgcgg gcttcttccg
     3181 ctttacggcg ttctgccaac tcttcatcgc ttaccttcac attaatcgta cgttcaggga
     3241 tatcaatctc gattatatcg ccgtctttca ccagtccaat cgctcctcct gccgcagctt
     3301 cgggagaaat atgaccgata gaaagaccgg aagtaccgcc actgaaacga ccgtctgtga
     3361 tcagcgcgca ctccttgcct aaatgacggc tttttatata agaagtagga taaagcattt
     3421 cctgcatacc cggaccaccc ttcggtcctt cgtgtgtgat caccaccaca tcgcccgaga
     3481 cgacttttcc accgaggatg ccttcgcaag ccgcatcctg cgaatcgaac actttcgccg
     3541 gaccggcaaa cttccagatg ctttcatcca caccggccgt cttgaccaca caaccgtcca
     3601 gcgcgatatt tcctttcagg acagccaggc cgccatcttt ggaataagca tgctcgatat
     3661 cacggataca tccggcggca cgatcggtat ccagttcctt ataataggtt tcctgcgatc
     3721 ccatccgaat gctgaaacga tgggcgggag cactcttgta tttcttgaca gcctcgtccg
     3781 tcacattcgg cgaggtgata gcaaatttat ccacggcttc ggcaagcgtc attccgtcca
     3841 cacgcttcac attcccgtct accaagccgt ttttcagcag ctcgttcatg attcccatga
     3901 taccaccggc acggttcaca tcctggacgt ggtaggtgtg cgtgttggga gcaaccttgc
     3961 agaggcaagg agtcttgcgg gagagcatat cgatatcgtc catcgtgaag tccgcctcag
     4021 cttcctgcgc gatggcgagc aagtggagaa ccgtattggt ggaaccaccc attgcaatat
     4081 ccaatgacat ggcattcagg aaagcctgac gggtggcgat actgcgggga agaacagact
     4141 catcaccgtc acgatagtat ttataggcat tttctacaat ctgccgggca gcatcgcgga
     4201 acagctgtgt acggcccaca tgcgtagcga caatcgtacc gttgcccgga agagccaggc
     4261 cgatcgcttc gttcaggcag ttcatcgagt tggccgtaaa cataccggaa caacaaccgc
     4321 atcccggaca ggcattccgt tccacctgtg cgatccgttc atcgctgacc gaagtgtcgg
     4381 ccgattcgat catggcatcg atcaaatcca gatggcggtt atccagctca ccggcttcca
     4441 tcggaccgcc ggagacaaaa atagtcggaa tattgagccg catggatgcc attagcatcc
     4501 ccggagtgat cttgtcgcaa ttgctaatgc aaaccattgc atcggctttg tgggcattca
     4561 ccatatactc gacgctgtcc gcaataatat cacgcgaagg aagcgaatag agcattccgt
     4621 cgtgtcccat agcgatacca tcgtcaatgg caatcgtatt gaattcggca gcaaagcaac
     4681 ccaacttttc aatctccgct tttacctgct gcccgatctc gtgcagatgg acatggccgg
     4741 gtacaaactg ggtaaatgaa ttcacaatgg ctataatcgg tttaccgaac tgctcttctt
     4801 tcagaccgtt ggcacgccac aaagcgcgag ccccagccat gcgtctgccc tctgtgctgt
     4861 atgaacttct taacggattc ttcatcatat tatttgttgt tttcgaacgg ctcacgaacc
     4921 gcccctattt tcttatccta aatattatta tattaaaaaa gcccttctct gtatggagaa
     4981 agacttaaga aatatcttta tatgacttca caatttcttg cacacctttc tccttacctg
     5041 ctaatgacta gaaggaccac cacgagaata atatgcaata cattgttcat catcttttct
     5101 tacatcttta ttattgtttg atgctgcaaa tgtagaacaa taattcatac caccaaagaa
     5161 attaaaagaa aaatatcaat ttatcttaca tttctcaagc aaagaaacaa gataggcttg
     5221 cagtttaaca catccttcca atcttccatt atcaaatccg aaatacctgt ctggattgtt
     5281 tccgcctaac ttttcatatg aaagaatata cgagtaggct tcaccatcgt cttgctatat
     5341 attttaaaat aaaagcagat ctttaaggta aaggcaggca ttcggactgg cttcacctta
     5401 aagatctgct ttcaccctgt ctcgtacaga tttaattata acctcttacg tttttgccca
     5461 aggccgaaag cctttttgcc taatggcaaa agccttttcg accttgggca aaaagatatt
     5521 cgacgtaggt caaaagctct atggctttat agcctaacga taaaagtatg gcagttgcca
     5581 ctctatgata cttttcgttc ccgactcatt tacaagtgtc agttatttac atttatagac
     5641 acctataaca ggatttttaa tacacagtca atctatttca ggacgagaca aaattaaaag
     5701 tccggttgtg taactaccca aatgtcggaa tcgaaacagt ttctaaatat aattcgtatc
     5761 tttgaccccg atcaacagac tgaacttata gagataatga aacaatacaa ctttgacgag
     5821 atcatcgaac gtcgtggaac caattgtgtc aagtacgatc ttctaaagaa agacttcggt
     5881 aacgagaacc ttgttccact ttgggtagcc gacatggatt tccggacacc agactttatt
     5941 gtcaacgcaa tcaagaagcg tctggagcat gagattttcg ggtacacatt cgactcggat
     6001 tcctattata acagtatcat cgagtgggta cattataaac ataactggaa aatccaacgc
     6061 gaatggctta gttatattcc cggcatcgta aagggaatcg gcttcgtttt gcaatgcttc
     6121 accaaacctg gtgacaaagt aattatccag ccaccggtct accatccttt ccgcatcgtt
     6181 ccggaaaaca tgcaccgtga ggttgtctac aacccgctca aaacagtaga cgacatttac
     6241 gagatggatt tcgagaatct tgaatcggtc atcgatgagc attgcaaggt cctgatcctt
     6301 tgcaaccctc ataatccagg cggtgtcgtc tggaaaaaag acacactggt caagttggcc
     6361 gaggtttgtg ccaaacacaa tatactcgtt atctccgatg aaatacatgc agagatggct
     6421 tatccgcaat atacgcatca tccgtttgca acggtttcgg agacagccgc caattgcagc
     6481 attactttca tggctccgag caagactttc aacattgccg gaatcgtcac ctcctattcg
     6541 atcattccca atgcggaaat acgagaaaaa ttctattcct tcatggaagc aggagaattc
     6601 aatgccggga cggtctttgc ctatacggca acagaagcgg cttatacata cggagccgaa
     6661 tggttgcaac agatgcggat gtatatcact gagaatgtcc gcttcgtaga tgaatattgc
     6721 aaatccaaac tcccgaagat caaagtctat ccccctcagg catctttcct tgtatggttg
     6781 gattgccgtg acctgaaact aagccagcct gaactggtaa gcttgttcca agataaagcc
     6841 ggcctgttgc tgaacgacgg aagcatgttc ggtcccggag gtgaagggca tatgcgtttg
     6901 aatatcggct gtccgcgttc cgtcctgtct tccgcactgg atgctttgaa aaaagcgata
     6961 gataagaaat aaagtcgttt gcctgtttaa ttatccagag attgggcaga caagtcggaa
     7021 attatgcgta aatttgttgc cattttattt atcataaata caattacaaa tgaaaattac
     7081 agcaaataag ttcgttgcag ttacttacga tctgaacgta ggcgaaggcg aagaacgcga
     7141 attgatggaa agagcaacag ctgaaacacc tctgaaattc atctttggta caggcgctat
     7201 gctccccgct tttgaagacg ctctgaaagg actggaagta ggcgacaaat ttaatttttc
     7261 cataactccg gctgatgcat acggcgaata tgtggaggaa cacgtactgg atcttccgaa
     7321 gaatattttc gaggtagacg gcaagttcga ctcggaaatg atcaaagaag gcaacacggt
     7381 accgatgatg gattcgaacg gcaatcgtat gaacggttct gtcttggaag taaaagaaga
     7441 tgttgtcgtt atggacttca accatccgct ggccggcgaa acattgcatt tcaatggtga
     7501 agttatcgat gtacacgaac cgacagctga agaaatcgca gccctcacag ctccggcagg
     7561 tggatgcggt tgtggatgtg acgactgtgg aagcggttgt ggcgaccata accacgaaag
     7621 tggatgcgga tgtggcggat gccattaaag aattgacaat tgacaatttt agcaagggtg
     7681 aatacatttg gaaacatata cagactgacc tctttcggag agtcgcacgg tcccggaatc
     7741 ggaggcgtaa tagacggatg ccctgccggt atcgaactag atacggcatt tatccaaagt
     7801 gaactgaacc gccgtaaacc gggacagtcc aaaatcacaa ccccacgcaa ggaagacgac
     7861 gaagtacagt tcctttccgg tatttacgaa ggaaaaacga cagggactcc gatcggtttc
     7921 gttatctgga acaagaacca gcactcggcg gactacgata atatgaagaa tgtttatcgt
     7981 ccttcccatg cagattacac ctaccagacc aaatacggaa tccgcgaccc gcgcggaggt
     8041 ggacgttcgt ctgcacgtga aacgatcgcc cgttgcgtag ccggagcaat tgccaaactg
     8101 gttcttcgcc agaaaggtat ccggatacaa gcatttacct cacaggtcgg gaacatcaaa
     8161 cttaacggct catacacgga ttacgacttg gacaaggcgg aagatacggc cgtacgttgt
     8221 ccggacccgg cgaccgccga aaaaatggag gctttgatcg ccgaagtgaa atccaaagga
     8281 gatacgatcg gcggcgtaat cacctgcgta gcacagggag ttcccattgg tctgggcgaa
     8341 ccggtattcg gaaagttgca tgcggcattg ggacatgcga tgttgacaat caatgccgta
     8401 aaagggttcg aatacggtga cggtttcgaa gcggccttat atcgtggctc ggaacggaac
     8461 gaccgtttct tcaacgacaa cggacacatc aacacccata cgaatcattc cggtggcata
     8521 cagggaggta tctcgaacgg gcaggatatt tatttccgtg ttgccttcaa atcggtcgcc
     8581 actatcctga tggaacagga aaccgtcaat acggaaggtg aagacacgat cctgaaagcc
     8641 cgcggacgcc atgatccgtg tgttttacct cgagctgtcc ctatcgtcga atcaatggca
     8701 gcaatgacac tgttggattt tctgcttatg cagaaaatcc gaaattgaga attgacaatt
     8761 gacaattaaa tgtatcagac aattatcaga ttgtattttt aattgtcaat tgccaattat
     8821 tcatggtgat agggttcatt attcagaatt gtcatcgccc tatagagctg ctcgataaag
     8881 accaggcgga tcatctggtg ggagaaagtc attttgctta aggatatttt ctcggcggcg
     8941 gctttataaa cagcatcgct gaaaccatac gggccaccga caacaaaaac caggcgcttc
     9001 gggactgtat gcgtctttct ttctatatag gtggaaaact gcaccgatgt aaattctttt
     9061 cctttttcat ccaacaaaac caaatagtca cccggctgta atgctttcag aatcaaatct
     9121 ccttccctct ctttttgttg ggattcggaa agatttttga cgttcttaat atcagggatc
     9181 acttccattt caaaagggat ataatgaacc agacggttct tatactcatt gatcgcttcc
     9241 acaaaatagc cggcatccgt cttgccgatc acaatcagtg caattttcat tcgtttacat
     9301 tttagagatt gaggacgcta aattacagga aaaaatacat acctttgcac gataatactc
     9361 acaaaaagag gaaaaagctt atgaaacgat tatttctgac gttggcattg gttctctcgg
     9421 ttctgagcgt aatggctgcc gatatacttc ctatatcaaa tgcttttaaa ggaggcaacg
     9481 cctcgtcgct cagcggatca atggacaagg aagtcgatat ggccctaccg ggttcatcca
     9541 aaaagtgcaa cgcaaacgac gctgtttcaa tgctgaacac cttcttcgga gggaacaagc
     9601 cgacaggatt tacagtcgtc caccatgctg ataaaaaaga aaatggcttc tttgttgcca
     9661 aactgcctac ttcatccggt gaatatcgcg taaacgtgac ataccgtgca gaaggaaaca
     9721 aagcgataat acagtctatc agaattgaat aaaaagatct tacaaacaat aacatgaacg
     9781 tacaagaaac aaaagaacaa ctgattgcag aactgatccg cctggcattc gcagaagata
     9841 taggagatgg cgaccatacg actttatgtt gcattccggc tacggaaatg gggaagagcc
     9901 agctgatcgt gaaagaagac ggcgtattgg ccggtgtcga aatggctgaa cgtattttcc
     9961 acacattcga tccggagctg aaaatgacga cattcatcca tgacggagcc gaagtgaaga
    10021 aaggcgatat cgctttcgtt gtcgaaggga aggtacagtc tttgttgcaa acggaacgct
    10081 tgatgctcaa cgtcatgcaa cgcatgagcg gtattgccac cacaacacgc aaatatgtca
    10141 aggctctgga aggaacgaaa acacgcgtgc tagatacgcg taagacgact ccaggtctgc
    10201 gtatggtcga gaaagaagcg gttaaaatcg gtggcggtgt caaccatcgt atcgggttgt
    10261 tcgatatgat tttgctgaag gacaaccatg tggactttgc cggcggtatc gaagcggcca
    10321 tcacacgctg ccatcagtat ctgaaagaga aaaacaagga tttgaagatt gaaatcgagg
    10381 ttcgtaactt cgacgagtta caggaagcaa tgcgtgtcgg cggtatcgac cgtatcatgc
    10441 tggacaactt caatatcgag aatacgaaga aagccgtcga aatggttgcc ggacgttacg
    10501 agctggaatc ttcaggtggc atcacattcg ccacgcttcg cgattatgcc gaatgcggtg
    10561 tggattatat ctcagtcgga gccctgacac actctgtcaa ggggctggat atgagcttta
    10621 aggcttgcta aagacattaa ggcgggcgga tctcgtctct acgaaatacg cgtcacgacg
    10681 cccccctcta acaggtattg ctgattgctt tccgggcatg tggcgatacc tttttcattg
    10741 aaggagaggc gatgcccgta ttcgctcacc caaccgatct gacgggaagg attgccgaca
    10801 accaaagcgt atggcggaat atctttagtg accacggccc ctgcgccgat catagcatat
    10861 tcgccgatcg tatgaccgca aacgatcgtt gcgttcgcac cgatagaagc acctttgccg
    10921 acatacgttt tcaaatattg gtctttacgg gaaacggcac tgcggggatt gaccacattt
    10981 gtaaaaacgc agctgggtcc taaaaaaacg tcatccccgc aagtcacgcc ggtataaacg
    11041 gaaacattgt tctgcacctt cacattattc cctaaaacca ccagaggaga gatcacgaca
    11101 ttctgcccga tattacaatt ccgaccgatt gtgcaccccg gcataatatg ggaaaaatgc
    11161 cagatgtgtg tgccgtctcc aattgtgcat ccgggatcga taacggctgt ttcatgtgcc
    11221 ttataagttt ccatttactt atatattaag aagattgtcg gtttcttgct caaatcagga
    11281 acctttccgg cccattcttt aacaggacgc gtatggatat attcatcttc gcaagtgata
    11341 ttcgaagcaa tacacaattt ggtcgaagga cggcacgtgc ggatcaactc ctccgccaat
    11401 ttattattgc ggtaaggcgt ttcgatgaac aactgcgtct ggttctccga ataaatgcgc
    11461 ccttccagct tcttgatcgc attcgtacgc tgtgaagcat cgatcggcag atagccatga
    11521 aaagcaaagc tctgcccgtt aaaaccggaa cccatcaccg acatcaggat cgaagaaggg
    11581 ccgaccagcg gaaccacctt gtaaccttta cgctgtgcaa tagccaccac atctgccccc
    11641 ggatcggcaa ccgccgggca gccggcctcc gagatcacac cgaccgactc gccttccgcc
    11701 aaaggagcca gataagcggc aacggcttcg gccgacgtat gcttgttcaa ttcataaaag
    11761 acaagatcgt caatcacgat cgaaggctct gtctttttca ggaaacggcg tgccgtacgt
    11821 acattttcga caatgaaatg acggatggaa aggataacct cccggttgta ttcgggaagg
    11881 acccggcgat gttcgacgtc gccaagcgtg acagggatga gatagagagc ggacatgaat
    11941 ttatgattta tgatttatga tttatgattt atgaccatga taaaaaaggc gacatggcca
    12001 taaatcataa atcataaatc ttaaatctta cgcaaaagta gtatttttgc cgaaaacaag
    12061 cgaaaagaga tggcacttcc gatagatttt atcacacgta cccgcgcatt gctgggaaat
    12121 gagttcgaca gtttcgaagc ggcgttgcag gccgatgtcc ctgtcagtat ccgtatcaac
    12181 gagaagaaag gcactcctgc tccgtcgacg gccggtgcgc cgtgcgaacg ggtggcctgg
    12241 tgcgagacag gctattacct gcccgaaagg ctttcgttca ccttcgatcc gctcttccat
    12301 gccggcgcct actacgtaca ggaagcgtcg tccatgtttc tcgaacaggc gatccgcagt
    12361 catgtgaaaa cgcctgtccg atgtctcgac ctatgtgcag ctccgggtgg taaatcaact
    12421 catctggcgg cgtgcctgcc ggaagggagc ctgctggtca gcaatgaagt gatccgtagc
    12481 cggagtcata tacttgcgga aaatatcgcc aagtggggaa atccgaattg catcgtgaca
    12541 aacaatgatc cgaaagagat cggctgcctt acgcatttct ttgatgtgat cgtcgccgac
    12601 gtaccctgtt ccggcgaagg catgttccgc aaagataccg acagcacagg cgaatggagt
    12661 gtcgcgaacg tcgaactctg tgccggacgc ggacgccgca tcatccacga tgtctggaac
    12721 gcactgaagc ccggtggtct gttgatctac agtacctgca cctacaacat ggaggaggat
    12781 gaagagaata tccattatat aacggaagaa ttgggagccg aaacactgcc catccccata
    12841 aaggacgaat ggcaaatcac cggcccattg aaatataacc atccggtcta ccgtttcttc
    12901 ccgcacaaga ccaagggcga aggtttcttc ctcgccgccc tgcgcaaagc ggatggcgag
    12961 acggaggaga tccggttcaa aaacaagaat aaaaaagaaa agggaaaaac agttcctgcc
    13021 gtcccggaag cagccagagc ctatctgttg gacaccacct ccttcacacc cgaatggagc
    13081 ggaagtaccc tctggatgct ccccgaaccc gtccgagacg tgtatcccct gctccgcgag
    13141 cacctgcgca ttctttcggc cggcatctgt atcggcgaga cgaaaggaaa agatttcatc
    13201 cctgccgaag aactggcact cagcacggct ctgtgcccag atgctttccc cgtggctgat
    13261 ttagattggg acgatgcgat ccggtatctg aaaaaagaag ctctcctcct gcctgccggc
    13321 acagagaaag gctacgtatt ggtccgttac aaaaagtttc cgctcggttt caccaaacat
    13381 ctcggcaacc gtgccaacaa cctctacccg caggaatggc gcatccgcac agggtatgtg
    13441 ccggagaagg tgaagacatt cgaaatgaag gtttagggac gtgacggccg cttgtgatag
    13501 acactattcg cttttcacca cctccgccgg attactgttg gccgccctca acacttgccc
    13561 cagcacggta aggagtacca ccgcgaccac tcccgttatc acgccggcca acaaccacca
    13621 ggggatgtcc gtacggtagg catacccttg cagccaacgg ctcatggcga tgtaagccaa
    13681 cgggaacgcg accgcgccgg caagcatcac ctgcaccgta tattcgcgga agaacatgcg
    13741 gatgatatcg cccaccctgg cccccaccac cttacggaca gcgacctcct tgcgccggcg
    13801 ctgcgtggag gctgaggcta cggcataaat gccgaacaac gagatcagca ggcaaacgac
    13861 cgccagaacg gaaaacatct tcagaccggc ttgctccgaa taattcagac ggtcatacat
    13921 ctcgcttaac cgtaccggat gaacatctac aaaagaggca tctatcgcgg gcaacactgc
    13981 gtttatccgc cggatcgcct cctgctcctg ccccggcaca gcacggacat acagactgtt
    14041 tgtcggataa accgatggga agaagatcgt tggaagaatg cggctacgaa gcgaaaagag
    14101 atggaaatcc ttcacaacac cgaccacccg gtattcttcc ggctcattca atgtcatgcg
    14161 gataacggtg cccaccggct cctcaagccc catcgcacgg acagcttcct cgttgagcac
    14221 gacattacgc tctccacctt cacccaacca ctccccttga agcatgttga ccttaaaggt
    14281 ttcggcaaac cggctgtcgg tcggcacgac acagaatgcc gatttttcgg attgcgtctt
    14341 ccccggccac tcgatatccg tttttatgtc ggaaggagtc gcactgtgct tcggcgtaaa
    14401 ataggtatcc gtcacattcc cgacttgcgg gatcgaagcc a
//
