LOCUS       gnlProkkaJCOLNFCF_22   30971 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|JCOLNFCF_22.
ACCESSION   gnlProkkaJCOLNFCF_22
VERSION     gnlProkkaJCOLNFCF_22
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-18 00:28:46
            Original ID  :: gnl|Prokka|JCOLNFCF_22
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 30971
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..30971
                     /aStool="rule-based-clusters"
                     /category="PKS"
                     /contig_edge="True"
                     /core_location="[3365:10971]"
                     /cutoff="20000"
                     /detection_rule="(APE_KS1 or APE_KS2)"
                     /neighbourhood="20000"
                     /product="arylpolyene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      3366..10971
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(APE_KS1 or APE_KS2)"
                     /neighbourhood="20000"
                     /product="arylpolyene"
                     /protocluster_number="1"
     cand_cluster    1..30971
                     /SMILES=""
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(APE_KS1 or APE_KS2)"
                     /kind="single"
                     /product="arylpolyene"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..30971
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="arylpolyene"
                     /region_number="1"
                     /rules="(APE_KS1 or APE_KS2)"
                     /tool="antismash"
     CDS             complement(472..714)
                     /locus_tag="ctg22_1"
                     /transl_table=11
                     /translation="MKAFGTYLRDGGLYSDVVRCENLLDKIRFDMNNDNANLFPIYSRA
                     YRTEVFSLSQVVKGEVNRVVDVTKFVYIIESQLDR"
     CDS             1086..2609
                     /locus_tag="ctg22_2"
                     /transl_table=11
                     /translation="MIADKSINLDTLHKVLFDNEKLELSEECIRKVEESFDFLQSFSSD
                     KIIYGINTGFGPMAQYRIEDQSLIDLQYNIIRSHSTGAGKPLPELYVKAAMIARLYTFL
                     QGKSGVHLELVSLLCEFINRGIYPFIPEHGSVGASGDLVQLAHIALTLIGEGEVFYQGK
                     LCNAATVLQENGLKPFSMRIREGLSVTNGTSVMTGIGIVNLIYAKKLLRWSVAASVMMN
                     EIAASYDDFMAQALNEAKHHKGQQEIAAMMREWVAGSKCVLQRENELYNQVHKEKIFEH
                     KVQPYYSLRCVPQILGPIYDELENAEEVLINEINSACDNPIVDPDTQNIYHGGNFHGDY
                     ISFEMDKLKIAVTKLTMLCERQINYLFHDRINGILPPFVNLGVLGLNYGLQASQFTATS
                     TTAECQTLSNPMYVHSIPNNNDNQDIVSMGTNSALLAKTVIENSYQVMAIQFMGMAQAI
                     DYLKIQDRLSSKSRQVYEEIRSFFPVFTNDTPKYKEIEMMIDYLKKEDK"
     CDS             2611..3339
                     /NRPS_PKS="Domain: PKS_KR (3-169). E-value: 8.1e-16. Score:
                     50.3. Matches aSDomain: nrpspksdomains_ctg22_3_PKS_KR.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     214.9; E-value: 2.1e-65)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg22_3"
                     /sec_met_domain="adh_short (E-value: 1.1e-34, bitscore:
                     111.0, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKYALVTGGSRGIGRAVSCKLAEMGYFILINYQNNDAEAEKTLQL
                     VQEKGSNGELMKFDVTDPAAITLALGNWASQHPDEYIEVLINNAGIRKDNLMLWMTGEE
                     WSKVLDISLNGFFNVTQPLLKNMLVKRYGRIVNIVSLSGIQGMPGQTNYSAAKGGVIAA
                     TKALAQEVAKKKVTVNAVAPGFIRTDMTEGIDENEWKKHIPAGRFGTPEEVADLVGFLA
                     SPASSYITGEVISINGGLYT"
     aSDomain        2620..3117
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg22_3_PKS_KR.1"
                     /evalue="8.10E-16"
                     /label="ctg22_3_PKS_KR.1"
                     /locus_tag="ctg22_3"
                     /protein_end="169"
                     /protein_start="3"
                     /score="50.3"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="ALVTGGSRGIGRAVSCKLAEMGYFILINYQNNDAEAEKTLQLVQE
                     KGSNGELMKFDVTDPAAITLALGNWASQHPDEYIEVLINNAGIRKDNLMLWMTGEEWSK
                     VLDISLNGFFNVTQPLLKNMLVKRYGRIVNIVSLSGIQGMPGQTNYSAAKGGVIAATKA
                     LAQ"
     CDS_motif       2623..2685
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg22_3_0001"
                     /evalue="2.90E-04"
                     /label="PKSI-KR_m1"
                     /locus_tag="ctg22_3"
                     /protein_end="25"
                     /protein_start="4"
                     /score="13.5"
                     /tool="antismash"
                     /translation="LVTGGSRGIGRAVSCKLAEMG"
     CDS             3366..4589
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (65-404). E-value:
                     1.3e-53. Score: 174.2. Matches aSDomain:
                     nrpspksdomains_ctg22_4_PKS_KS.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     arylpolyene: APE_KS1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022:Beta-ketoacyl synthase (Score: 295.8; E-value:
                     9.1e-90)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg22_4"
                     /sec_met_domain="APE_KS1 (E-value: 1.9e-159, bitscore:
                     521.7, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRVVITGMGIYSCIGKNLDEVKDSLYHGKSGIGIDPVRKELGYF
                     SALTGILERPDLKKLLDRRKRLCLPEQGEYAYLATLEAFRNAGIDENFLESNEVGILYG
                     NDSSAAPVINAVDIIREKKNTALVGSGSIFQSMNSTVTMNLSVIFKLRGVNFTIAGACA
                     SGSHAIGMGYLLIKSGLQDCILCGGAQEVNPYAVGSFDGLSAFSTQEAAPEKASKPFDK
                     RRDGLIPSGGAASLVLESYESAVKRGAPILAEVIGYGFSSNGDHISVPNVDGPKRSLQM
                     AIKDAGIALEQISYINAHATSTPVGDLNEAKAIAEVFEGHHPYVTSTKSMTGHEMWMAG
                     ASEVIYSTLMMNNGFIAPNLNFEEPDEASAQLNIPTQRVNLEFDTFLSNSFGFGGTNST
                     LIIRKINP"
     aSDomain        3561..4577
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg22_4_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="1.30E-53"
                     /label="ctg22_4_PKS_KS.1"
                     /locus_tag="ctg22_4"
                     /protein_end="404"
                     /protein_start="65"
                     /score="174.2"
                     /tool="antismash"
                     /translation="RLCLPEQGEYAYLATLEAFRNAGIDENFLESNEVGILYGNDSSAA
                     PVINAVDIIREKKNTALVGSGSIFQSMNSTVTMNLSVIFKLRGVNFTIAGACASGSHAI
                     GMGYLLIKSGLQDCILCGGAQEVNPYAVGSFDGLSAFSTQEAAPEKASKPFDKRRDGLI
                     PSGGAASLVLESYESAVKRGAPILAEVIGYGFSSNGDHISVPNVDGPKRSLQMAIKDAG
                     IALEQISYINAHATSTPVGDLNEAKAIAEVFEGHHPYVTSTKSMTGHEMWMAGASEVIY
                     STLMMNNGFIAPNLNFEEPDEASAQLNIPTQRVNLEFDTFLSNSFGFGGTNSTLIIRK"
     CDS             4611..4862
                     /NRPS_PKS="Domain: PP-binding (7-75). E-value: 3.8e-14.
                     Score: 44.9. Matches aSDomain:
                     nrpspksdomains_ctg22_5_PP-binding.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg22_5"
                     /sec_met_domain="PP-binding (E-value: 2e-14, bitscore:
                     44.9, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTNEEIIEKIRTTLAEEFEVDIDVIQPDAPLMETLELDSLDLVDM
                     VVLVEKNFGFNVTGQDFAGIKTFQDFYDLVITRMQEAK"
     aSDomain        4632..4835
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg22_5_PP-binding.1"
                     /evalue="3.80E-14"
                     /label="ctg22_5_PP-binding.1"
                     /locus_tag="ctg22_5"
                     /protein_end="75"
                     /protein_start="7"
                     /score="44.9"
                     /tool="antismash"
                     /translation="EKIRTTLAEEFEVDIDVIQPDAPLMETLELDSLDLVDMVVLVEKN
                     FGFNVTGQDFAGIKTFQDFYDLV"
     CDS             4865..5776
                     /locus_tag="ctg22_6"
                     /transl_table=11
                     /translation="MSTWKGKTRGGTFGYLFFIYLIKYLGITAAYIFLSLVVLYFIPFA
                     PKATKSTWFYARHILKYNRIRSLGMLLRNYYRLGQILIDKVAIGNGKVDQYRFEFERYP
                     EFLQLLNSEQGVIMIGAHVGNWEIGVPFFDDYGKKINIVMYDAEHRRIKEILEKNGQDK
                     DFKIIPVNEDNLTHVFRITEALNKKEYVCFQGDRYLNKEKLLTGTLLGQKAPFPAGPFL
                     LGSRMKVPVVFYFAMREPGRTYRFHFIRTEPVIRTKEKKAETALLEQYTAALDQILKRY
                     PEQWFNYYSFWETTSDGSLSKG"
     CDS             5802..6872
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1042:O-methyltransferase (Score: 125.5; E-value:
                     4.6e-38)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg22_7"
                     /transl_table=11
                     /translation="MQQNQYDKEPLTAVEAQRLAQEIAFGPIVFQVSRLMLKFGIFQLL
                     ADERAGMTQEEISKACELSSYATQVLLEASLTIGTVLQHENRYRLAKAGWFLLNDKMVR
                     VNMDFNHDVNYLGMFHLEEALTNGRPEGLKVFGEWSTIYEGLSSLPSQVQKSWFGFDHY
                     YSDCSFDEALAIVFARHPKTLLDVGGNTGRWATKCVSYDDAVEVTIMDLPQQLEMMRQQ
                     TKELPGAMRIHGYGANLLDPEVPFPTGFDAIWMSQFLDCFSEEEVTSILTRAARSMSRE
                     SRLYIMETFWNRQKFDTAAYCLTQISLYFTAMANGNSKMYHSDDMERCIKAAGLEVEKI
                     DDHLGMGHSIVQCRLK"
     CDS             6857..7306
                     /locus_tag="ctg22_8"
                     /transl_table=11
                     /translation="MQIEMNNREVIIQGEGILNLIPQRPPIVMVDSFFGIEENHSYSGL
                     TVTADNIFCETRKLQEAGIIEHIAQSAAARIGFLYTRQGEKVPLGFIGSVDKLKIYDLP
                     KIGMKLFTEITVVQEVFDITLISAQVKVEDKLIAECRMKIFIKKE"
     CDS             7303..7746
                     /locus_tag="ctg22_9"
                     /transl_table=11
                     /translation="MKRKTNQQVATLTNRTTFRVRFSEIDSMQIVWHGEYVRYFEDGRE
                     AFGKQYGLDYMSIYREGYMVPIVDLTCQFKQSLSFGEEAIVETRYIACEAAKIKFEYVI
                     YRATDQSIVATGSTIQVFLNLNKELELMNPPFYLEWKKKWNIL"
     CDS             7731..9503
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (125-376). E-value:
                     3.7e-27. Score: 87.1. Matches aSDomain:
                     nrpspksdomains_ctg22_10_PKS_KS.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     arylpolyene: APE_KS2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022:Beta-ketoacyl synthase (Score: 169.9; E-value:
                     1.5e-51)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg22_10"
                     /sec_met_domain="APE_KS2 (E-value: 2.4e-108, bitscore:
                     353.5, seeds: 16, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEYPLNIYITAHTLISSLGFGIPENLEAIHNYRSGIRMQEAGLIS
                     DHPLLAGMIDSVELEKRAKLMQITDYTRMEQLFILAIQKVISQSGTDLREPDCALLLST
                     TKGNVDLLSELPADSPVFLWKMAERIGDFFGAANQVEVISNACISGVSALIVAKRWIES
                     GRYKRVIVAGGDILSHFITSGFLSFRSVSAHPCRPYDIQRDGLSLGEACGAVLLETQGN
                     ANHIILSGGAISNDANHISGPSRTGDGLALAINQAMEEAGALPEDISFINAHGTATVYN
                     DEMESKAIHLAGLAAVPVNSLKPYFGHTLGASGIIETILCIEQLKEGRYYGTLGYETLG
                     VPMPITVYATHQPIPMKCCIKTASGFGGCNAALVLSLPDAHLKQKANSQATDKASAPSV
                     YKAVVESGNMVTIRSGAVESKGTTVFSSSETDFAPFIREAYKHLGENNMKFYKMDNLCK
                     LGYVAAEYLLKDTNYHPKEIGIILANASSSLDTDCKHQAIISKEGDKAASPAVFVYTLP
                     NVVLGEICIRHKIQGENTFFVRRQSDAASLEDYARIVMAKGKLRTCIIGWCELLDGHYQ
                     AEFKQLNNISTIYG"
     aSDomain        8106..8858
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg22_10_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="3.70E-27"
                     /label="ctg22_10_PKS_KS.1"
                     /locus_tag="ctg22_10"
                     /protein_end="376"
                     /protein_start="125"
                     /score="87.1"
                     /tool="antismash"
                     /translation="MAERIGDFFGAANQVEVISNACISGVSALIVAKRWIESGRYKRVI
                     VAGGDILSHFITSGFLSFRSVSAHPCRPYDIQRDGLSLGEACGAVLLETQGNANHIILS
                     GGAISNDANHISGPSRTGDGLALAINQAMEEAGALPEDISFINAHGTATVYNDEMESKA
                     IHLAGLAAVPVNSLKPYFGHTLGASGIIETILCIEQLKEGRYYGTLGYETLGVPMPITV
                     YATHQPIPMKCCIKTASGFGGCNAALVLS"
     CDS             9496..9777
                     /NRPS_PKS="Domain: PP-binding (22-86). E-value: 1.4e-11.
                     Score: 36.7. Matches aSDomain:
                     nrpspksdomains_ctg22_11_PP-binding.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg22_11"
                     /sec_met_domain="PP-binding (E-value: 7.3e-12, bitscore:
                     36.7, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDNLDQTKRELMDEVKGKLIEELNLEEITPEDIDNEAPLFGDEGL
                     GLDSIDALEIILILEREYGIKIENPSEGKQIFYSVRTLADYIIANRKA"
     aSDomain        9562..9753
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg22_11_PP-binding.1"
                     /evalue="1.40E-11"
                     /label="ctg22_11_PP-binding.1"
                     /locus_tag="ctg22_11"
                     /protein_end="86"
                     /protein_start="22"
                     /score="36.7"
                     /tool="antismash"
                     /translation="LNLEEITPEDIDNEAPLFGDEGLGLDSIDALEIILILEREYGIKI
                     ENPSEGKQIFYSVRTLADY"
     CDS             9781..10971
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (77-388). E-value:
                     1.5e-37. Score: 121.3. Matches aSDomain:
                     nrpspksdomains_ctg22_12_PKS_KS.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     arylpolyene: APE_KS2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022:Beta-ketoacyl synthase (Score: 259.4; E-value:
                     1e-78)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg22_12"
                     /sec_met_domain="APE_KS2 (E-value: 7.2e-130, bitscore:
                     424.4, seeds: 16, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIYVTGLGVVSGIGIGVSENIEALRQRKHGIGKVTLFPTALDVP
                     VSEVKRSNEELKKLISLPPQRTVSRTALLGMIAAEEAMKDAGLTPSLRIGFISATSVGG
                     MDLSEHFYESFKKNPGQGRLREVISHDCGASTELIASYLGINDFITTISTACSSAANAI
                     MLGARMIKHGLLDAAIVGGTDALCRFTLNGFNSLMILDKTHCRPFDRSRTGLNLGEGAG
                     YLVLQSESSLQRTPYCELSGYANTNEAYHQTGSSPEGDGAFLSMSEAIASSGISPKEID
                     YINVHGTGTPGNDASEGMALRRIFGEHVPPFSSVKAFIGHTLGASEGIEAVYSVLSIDK
                     GLIYPNLNFTDAMPETGLIPETSFQEGIPIRHVLSNSFGFGGNDSSLLFSATNFPA"
     aSDomain        10012..10944
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg22_12_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="1.50E-37"
                     /label="ctg22_12_PKS_KS.1"
                     /locus_tag="ctg22_12"
                     /protein_end="388"
                     /protein_start="77"
                     /score="121.3"
                     /tool="antismash"
                     /translation="AAEEAMKDAGLTPSLRIGFISATSVGGMDLSEHFYESFKKNPGQG
                     RLREVISHDCGASTELIASYLGINDFITTISTACSSAANAIMLGARMIKHGLLDAAIVG
                     GTDALCRFTLNGFNSLMILDKTHCRPFDRSRTGLNLGEGAGYLVLQSESSLQRTPYCEL
                     SGYANTNEAYHQTGSSPEGDGAFLSMSEAIASSGISPKEIDYINVHGTGTPGNDASEGM
                     ALRRIFGEHVPPFSSVKAFIGHTLGASEGIEAVYSVLSIDKGLIYPNLNFTDAMPETGL
                     IPETSFQEGIPIRHVLSNSFGFGGNDSSLL"
     CDS             10996..11994
                     /locus_tag="ctg22_13"
                     /transl_table=11
                     /translation="MQPVYIQRIASIHPPKDHSPENNHPYLQACEPDYKDIITNATLRR
                     RMSRIVKMGVACGLECMGELSPEKIQGIITATGLGCLTDTEKFLNNLLDNEERMLNPTP
                     FIQSTFNTIGAQIALIHQIHAYNMTYVHRGLSFESALLDAMMKIGEGSENILVGAIDEM
                     TETSYTIQQRLGMLKGIAAGEGAQFFLLSREAGEHPLAEIQGIETFIGKQTTEEISSRI
                     IRFLQRNGLECQDIQWLVTGKNKKQHNQDDSHEQTVDNGNSIYEELETNLFPESAYLSF
                     KNECGEYPTATSYAVWKAVNESANCTTSTHILIYNHHHSINHSLILIRKSV"
     CDS             11991..12671
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1235:polysaccharide deacetylase (Score: 129.3;
                     E-value: 3.1e-39)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg22_14"
                     /transl_table=11
                     /translation="MIIVCLLLCLLLLLSFLVYASYSIQSGIYLRSFCKKHTAEKIVAL
                     TFDDGPDSLQTPKVLQVLKEYQVTACFFCIGHKVKGNEAILQKMVAEGHLIGNHSHTHS
                     GLFPLYGLSKMKKDLQTCQCELERVTSQPVSLFRPPFGVTNPTIAKAVRQLGYTSIGWS
                     IRTLDTQQPAPDKVLARIRKRLEPGAIILLHDRMPDSDQLVKQILDLLKEQGYTAVHPD
                     KLLA"
     CDS             12684..13319
                     /locus_tag="ctg22_15"
                     /transl_table=11
                     /translation="MRTLLIYLSLFFLSIASIHAQSMKKMAQKTEFESRLAKEAQTVES
                     IESDFTQVKYLDVFDEKVTSKGKFYYQKTHKICMEYFRPMDYLIVINGSKLKIVSDGKK
                     SIMNLSSNKMMAQMQDMLTACMIGDLSKMSSNYLLEYFEDARYYLVKIKPTNKAVQAYI
                     AGIEIYLDKKDMSVHKLRLSETATNYTEYEFYNKKFNSLKNETKFAIR"
     CDS             13294..13854
                     /locus_tag="ctg22_16"
                     /transl_table=11
                     /translation="MRRSLRFVSLTALLFLWIQIQTSCSPRMSGEGSTVPPAIELTQGE
                     SSQKYNIQLDFMKHHMSGMLIVRRMPDNEIRIVASTYFGLSLFDFSLRNDQFTVNNCIE
                     PMKKEKVLKLLEMDFRRLFLSGKDTRVKATKDSATEKRTSGKGFGKSVVYITGNTPGDP
                     AQIKIKHPWIRLTIRLDKLSKEI"
     CDS             13858..14292
                     /locus_tag="ctg22_17"
                     /transl_table=11
                     /translation="MLLDNFYTILSSESSDSTIWTIQIKLNPGHPVYQGHFPEHPVVPG
                     VCLLQLIKECVEDIRQQKLQVTQVSSCKFLSAINPIETPHISVALTFKETEEGTLQLQA
                     EGSVKKEAVKKSTVKESTVEENTVKDECFIKLKAALTPTV"
     CDS             14250..15479
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1123:polyprenol-monophosphomannose synthase ppm1
                     (Score: 78.5; E-value: 1.1e-23)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg22_18"
                     /sec_met_domain="Glycos_transf_2 (E-value: 5.4e-28,
                     bitscore: 88.9, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFHQTKSCTYPDSMKEQISTAYWHEKLKQLGIIVIIPSYNNGKTL
                     ADVIESVRFYAPDILVVNDGSTDETAEILSRESNLHIITHPVNQGKGVALRHGLSFAKK
                     QGFRYAITIDSDGQHFASDIPTLIEAIEKEPDTLLVGARNLASDNMPGKNTFANKFSNF
                     WFTLETGIKLQDTQSGYRLYPIQRMNVDKWYYTAKYEFELEALVFAVWGGITVKNIPVH
                     VYYPPQEERVSHFRPFRDFTRISILNTVLVLVTFLWIIPRNFFRKLTWKNCKQFFSDHV
                     THSPESNLRITAAITLGVFMGIVPVWGYQMLITLFLAHLFRLNKVIAIVAANISIPPMI
                     PFLLYGSYVTGCKVLGDPVNLHLNELSFENVKSVIEQYLIGSVIFAVVCSILAGTIAFI
                     LLTACRKKKI"
     CDS             15476..19333
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1035:MMPL domain-containing transport protein (Score:
                     45.2; E-value: 6.3e-14)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg22_19"
                     /transl_table=11
                     /translation="MTQFFIGLYDYFERHKILFYLSLISCVLLMGFFALQVRFEENITQ
                     FFPDTKDSQNTIKVFDNLKIKDKIIIMLSSADTCHRVEPDSLIEAAGQLQQTLTEKTGG
                     KLIKGIFAQVDQSLIQGATDFVYEHLPLFLTDTDYQRFDSLLTDKGIQAAMQKNYTNLL
                     SPAGIALRSYILRDPLGLGSETLKHLQDFQLEANYEIYDEHIFSKDGSTLLMFITPVFS
                     TGSTGKNDELIKMLEEELKHVQGESPTIRAEYFGGPSVGVYNARQIKKDTILTSSLALL
                     IIIVFISLVFKRKRSIPLIITPVLFGGLFALFLIFFIKGSISAIAVGAGSAVMGIALSY
                     SIHMLAHQNHVSTVQQLIKEIAYPLTVGSFTTIGAFLGLIFTSSDLLRDFGLFASLALV
                     GTTLFCLIYLPHFLKGQADVKQGRILRIIEKINAYSYEKNKWLVGGILLITVICLFTSQ
                     KVGFNNDMMSLNYEPRHLQQSEEKLLQLFDNDEKTVLFVSVGKDMNQATETYAMTNQKL
                     SALKEQGLIKEYASASQFLISPQEQQKRLKKWKDYWTDEKQQQVRKQLETAAAEYRFRS
                     GSFDSFYQWMNQPFGEYHYTAQGDDLSGKLLNEWQTSADSITMLISQIRISEPNKEAVY
                     QNFNKDPNVVIFDRSYFANKWVSAINDDFYLILYISSFLIFFALWFSYGRIELTLMSFL
                     PMLISWVIILGLMGILGIEFNIINIILSTFIFGIGDDFSIFIMDGLQNKYRTGQKVLNS
                     HKTAIFFSAFTTVVGMGALVFAKHPALQSISLISILGMIAVVLVAYTIQPLIFRFFIAG
                     PASKGLPPYTLIGLIRTVLLFLLFFIGCIVLRILIILLYPVPVRKSSKQRLVCRLIQIT
                     CKGILLLATAVKKEHINKANERFRHPAIIIANHQSFIDILVLLSLSSKILMVTNHWVWH
                     SPFFGAIIRYVDFYYIGEGYEQYMERMRKKVKEGYSIAIFPEGTRTYNGKMKRFHKGAF
                     YLAEALKLDILPILLYGNNKIIAKAQPFNIRKGIIYTEILPRIPLDDLSFGSTYQERTK
                     RISAYMKEVYARICREQNTTDNPAFYEALIQNYIYKGPVVEWYIRIKVKMEKNYRLFNR
                     LIPVQGQITDIGCGFGPLCYMLSLLSEDREILGIDYDEDKIALAQHGWLRNEHLQFKHG
                     NALEYPLPESDVFILNDMLHYMSYEHQQTLLLKCAGRLRSQGMIIIRDGNSANASKHRL
                     TRFTELLSTRIFNFNRTTGELYFTTETQLREIAVACGMAVEIIPNDKYTSNTIYIFRKP
                     N"
     CDS             19335..20825
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222:dehydrogenase (Score: 153.4; E-value: 1.8e-46)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg22_20"
                     /sec_met_domain="DAO (E-value: 3.1e-09, bitscore: 27.8,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKYDIIIIGSGLGGLECGAILSKEGFNVCVVEKNAQFGGCFQTY
                     QRKGHLLDTGIHYVGSLDEGQVMNQYFRYFGIMDKLKIKRLDDAAFDTIYYKGKTYDYA
                     MGYPKFIETICRSFPHEKENLKCYAEQLQAVGNLISVDHLKQGTLALEGMKYFCTSAAH
                     LIADITPDPALRNVLAGSALLYGGLKDVSTFYQHAMINHSYIEGAYRFVDGSMQVSLEL
                     INVIRANGGTVLNNSEATRIIVENEKVQGVIINGEERLESDFVISNMHPQRTLEILDKN
                     RSIKNAYISRIRSLENTYGIFTLYLVMKKKSTPYQNRNLYLHANNKVWYDKLLYPGRTT
                     NCMISMQASSEDSQYASVISILTPMYIDELSAWKDTTPEHRGEDYQSFKKEKAEQILRF
                     IRGHGIDLSENIEEMYTTTPLSYRDYTGTVDGSAYGIIKDYKCPQIGFVSTRSRLGNLF
                     LTGQNLNVHGALGVTLTAMLTCAEFVGQEYLAKKVGNA"
     CDS             20818..22515
                     /locus_tag="ctg22_21"
                     /transl_table=11
                     /translation="MHRIVKKTLQYTGFLFLLLIVLLIAGISYLYFSADMQTPKHEQSM
                     TTDKVIDIDSLHLRHYGDNFLRHSDSGLWELFVKGDAFQRGEAIGQLSSDLLHHQEKVF
                     VDQIREIVPSDSYLKFLRFFIVLFNRNLGENVLEEYRDEIYGISLSCTHEYDFIGTPYE
                     RQLNYHSAHDLGHAMQDYMLVGCSSFATWGTQSADSSLLIGRNFDFYVGDAFAENKQVA
                     FYVPEQGYRFASVGWPGMIGVLSGMNETGLTVTINAAKSAVPTGSATPISILTREILQY
                     AATIDEAFAIAQKRETFVSESILIGSAKDGKAAIIEKSPEKTVLFTGKEANRLICTNHY
                     QSEEFSKDERNMENIRTSDSPYRFARLTELINEDLPIDVSKAASILRDHKGLQNTDLGL
                     ANEMAINQFIAHHSVIFQPEKRLMWVSTSPWQCGKYIAYDLNKIFKDTIDWQHEIYSSA
                     LTIPEEKFIDTPEFQHLLTYKKLTPLLLKKIRKKEKIEESVLKTYQASNPSLYYVYEVI
                     GDYYETMQQPQQAIAYWQQALKRPIPKLQEKERIQQKIQKQSKDGKES"
     CDS             22499..23794
                     /NRPS_PKS="Domain: AMP-binding (46-308). E-value: 1.4e-14.
                     Score: 45.3. Matches aSDomain:
                     nrpspksdomains_ctg22_22_AMP-binding.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg22_22"
                     /sec_met_domain="AMP-binding (E-value: 2.6e-11, bitscore:
                     33.6, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEKNPEIQFRSPEDIKSYQEEQLAKALAYLQAHSKFYQQMFAEHH
                     IDINQIKTIEDLQQIPVTTKTDLQLHNDDFICVDKEEIIDYVTTSGTLGDPVTFVLTSE
                     DLDRLSYNEYLSFTTTGCTKQDILQLMTTIDRRFMAGLAYYMGARELGMGVIRVGNGIP
                     ELQWDTIRRIHPTCGMVVPSFLIKLIEFAEKNHIDHNTCSMQKCICIGEALRNQEFQLN
                     TLGQKIHDKWPALQLYSTYASTEMQSSFTECNEFHGGHLQPELIIVEFLDDNNRPVEEG
                     EAGEVTITTLGVKGMPLLRFKTGDICYHHTEPCGCGRNTIRLSSILGRKGQMIKYKGTT
                     LYPPALFDILDNIPSVKNYIIEVYTNELGTDEILIRIGSENRSEAFAKEIKDLFRSKVR
                     VAPSINFESAEYIAKIQMPPMSRKTIKFIDLR"
     aSDomain        22637..23422
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg22_22_AMP-binding.1"
                     /evalue="1.40E-14"
                     /label="ctg22_22_AMP-binding.1"
                     /locus_tag="ctg22_22"
                     /protein_end="308"
                     /protein_start="46"
                     /score="45.3"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="DINQIKTIEDLQQIPVTTKTDLQLHNDDFICVDKEEIIDYVTTSG
                     TLGDPVTFVLTSEDLDRLSYNEYLSFTTTGCTKQDILQLMTTIDRRFMAGLAYYMGARE
                     LGMGVIRVGNGIPELQWDTIRRIHPTCGMVVPSFLIKLIEFAEKNHIDHNTCSMQKCIC
                     IGEALRNQEFQLNTLGQKIHDKWPALQLYSTYASTEMQSSFTECNEFHGGHLQPELIIV
                     EFLDDNNRPVEEGEAGEVTITTLGVKGMPLLRFKTGDICY"
     CDS             23851..24420
                     /locus_tag="ctg22_23"
                     /transl_table=11
                     /translation="MKKLILFLFLSTSLFCFGQGKSALKDIQSIKFYGVDYSQVKVFGA
                     DESPVQFKDAFRRINELFITEAKKYNVGKQLKKEVTEISLDAVNQVNENIDLAELMTAK
                     REYTLSKEQIKAAINALPIQKTPGVGMVFIAQFLDKSNNRGTYEVVFFNTETKEIIEEW
                     ITDGKARGFGLRNYWAGSIYSALKKL"
     CDS             24437..25177
                     /locus_tag="ctg22_24"
                     /transl_table=11
                     /translation="MRKLLLVLTLLLSISTYVAAQNYTEVVYLKNGSIIKGVIIEQVPN
                     VSLKIKTGDGSLIICQMSDVTKITKEERYTRDYRKDTNDRKAARNTLKGYKGFVDFAYI
                     GDVSDYNASKIELSTTHGYQFNNYFFVGGGVAFNYYTDADLYAAPIYANFRANFINKKV
                     TPFADVKAGYSVGDIEGAYASIGVGVRFSLKGKKALNLALMYNFQDYDATTDYSYSYGG
                     HYYHNSWNDTWELHGVGARFGFEF"
     CDS             25296..25838
                     /locus_tag="ctg22_25"
                     /transl_table=11
                     /translation="MTSGTIDFIKDQQVIQFTFSYDEMLVGKLTENEYVEKKSSEYNAK
                     EEGKGDQWKAAWYGDRKERFEPKFLELFDKYMSEVGITAGSEGAQYRIEINTDFTEPGW
                     NVGVMRQNASVDLSCKVKKIETGEQVASIKIRNASANNFWGTDFTSGYRVQETYAKAGR
                     ELAKFFIKKAKLRKIKD"
     CDS             complement(26154..26999)
                     /locus_tag="ctg22_26"
                     /transl_table=11
                     /translation="MLIAILILCSIGIIKGQTVSDSLAIVSAQWKVESPQKGLIHKYAS
                     IPRLYQGPQSVSLIEVDPGAGLKVDVAVSGEMKETSRIASEHHAIAAINGSYFDMKRGN
                     SVCFLKVGDQVVDTTTLSESKWRVTGAIHLHKGKMKLIPWNRQTEKEYKEEAGTILASG
                     PLMLKDGQVCDWNSCEPNFIRTKHPRSAVATTKDGKILLITVDGRFPEQAGGVNIPELA
                     HLIRVLGGEDALNLDGGGSTTLWLSGASDNGVVNYPCDNGRFDHAGERKVPNILYITHQ
                     "
     CDS             27375..29093
                     /locus_tag="ctg22_27"
                     /transl_table=11
                     /translation="MNHKWNYRPITPEQAETSQTLAQELGISPILGQLLVQRGITKAAD
                     AKKFFRPQLPDLHDPFLMKDMDIAVERLNRAMGKKERILIYGDYDVDGTTAVALVYKFI
                     QQFYSNLDYYIPDRYNEGYGISKKGVDYAAETGVGLIIVLDCGIKAVEEITYAKEKGID
                     FIICDHHVPDDVLPPAVAILNAKRLDNTYPYTHLSGCGVGFKFMQAFAISNGIEFHHLI
                     PLLDIVAVSIASDIVPIMGENRILAYHGLKQLNSNPSIGMKAIIDVCGLSEKEITVSDI
                     VFKIGPRINASGRIQNGKEAVDLLTEKDFSVALEKAGQINQYNETRKDLDKSMTEEANN
                     IVANLEGLVDRRSIVLYNEEWHKGVIGIVASRLTEVYYRPAVVLTRTDDMATGSARSVS
                     GFDVYKAIEHCRDLLENFGGHTYAAGLSMKVENVNAFTKRFEEYVSQHILPEQTSAVIE
                     IDAEIDFRDISSKFFSDLKKFNPFGPDNTKPIFCTHHVYDYGTSKVVGRDQEHIKLELV
                     DNKSNNVMNGIAFGQSSHVRYIKTKRSFDICYTIEENTHKRGEVQLQIEDIKPIE"
ORIGIN
        1 gattaccatc aatattaggc aatttatgtg ccaaaagcat aacaaaagac tgatacaacg
       61 agacttgtca agtttaataa aagagattat atcactcatt ttcaaacaca taaacaattt
      121 gcaataaaga aaaaaagcat taatagccag attaagtttc aagcacgatc ctgtgcaaaa
      181 attccacaga aatgtggaca tattccacaa gataataagt taagaataat ccgtatttaa
      241 aagttccttt ccatccttct gattgtttcc acatatcaga agtcagaata aacgttccaa
      301 aactccagtt taaacgatta ttaactaatt tctcccccgt ctccgagaac agaatcagca
      361 gaaatatcta tctttgtccc aatttcaagc aagaaagcaa aagtgctatt tttgtgtcga
      421 atttaaaacg tttaagagaa aacaatggaa gaaatcgtat ttcatcacac attacctatc
      481 caattgcgat tcaatgatgt agacaaattt ggtcacgtca acaacacggt ttacttctcc
      541 ttttacgact tgggaaagac tgaatacttc ggttcggtat gcccgggagt agattgggaa
      601 aagattggca ttgtcgttgt tcatatcgaa gcgaattttg tcaagcaaat tttcgcatcg
      661 gaccacatcg ctgtacaaac cgccgtctct aagataggta ccaaaagctt tcatctggtt
      721 caacaagtca ttgatacgaa aaccaatgag gtgaaatgtg tttgcaagtc catcatggtt
      781 actttcgatc ttgaaagaca tgagtccatg ccactgacca aggaatggat agaagcgatc
      841 tgcaagtatg aaggacggga tttgcaaaaa gcatagattg atttttctcc ccaccgatga
      901 agacaccctc cggcaccaat gaaggcatcg agcggcaccg gggaacaaat ctcccacgaa
      961 tgagaaacaa aacaagcaaa accaattccc cagaaaaagt tttatcctga ttcatgtccg
     1021 ctatataaca gaaattgcct atttttgcac cttattatta aggcataaaa tatctagtac
     1081 agaaaatgat agctgacaaa agtataaatt tagataccct tcataaagta ttgtttgata
     1141 atgagaagct ggaactctct gaagaatgta ttcgaaaagt agaggaaagc ttcgattttc
     1201 tgcaatcctt ttccagcgat aagattattt atggtatcaa tacggggttc ggcccaatgg
     1261 cacaatacag aatagaagat cagtcattga tcgaccttca gtataatatc atccgaagcc
     1321 attccaccgg tgccggcaaa ccgcttcccg aactttatgt aaaagcagct atgattgccc
     1381 gtttgtacac ttttctacaa gggaagtcag gagtgcatct ggaactggtt tctctcctct
     1441 gtgaatttat caaccgcgga atttatccgt tcatacccga acacggaagt gtaggtgcca
     1501 gcggcgatct cgtacaactg gcccatatcg ccctgacgtt aataggggaa ggggaagttt
     1561 tttatcaggg taaattgtgt aacgcagcta cggtgcttca ggaaaacggc ctgaaacctt
     1621 tttccatgcg tattcgtgaa ggtttatccg ttacaaacgg tacttctgta atgacaggca
     1681 tcggtattgt caatctgatt tatgcaaaaa aactactccg ttggtcggtg gctgcctctg
     1741 taatgatgaa tgagattgcc gcctcttatg atgattttat ggcacaggca ttaaacgagg
     1801 ccaagcatca taaaggtcaa caagagatag ctgctatgat gagagaatgg gtggcaggca
     1861 gtaaatgcgt gcttcaaaga gagaacgagc tatacaacca ggtgcataaa gagaaaatct
     1921 tcgaacacaa agtacagccc tattattcct tgcgatgtgt tccgcaaata ctcggtccta
     1981 tttacgatga actggagaat gcggaagaag tattaataaa cgaaataaat tccgcctgtg
     2041 acaatccgat tgtcgatccg gatacacaaa atatttatca tggcggcaac ttccacggag
     2101 attacatttc tttcgaaatg gacaagttga aaattgccgt gaccaagctg actatgcttt
     2161 gcgaaagaca gattaactat ctgttccacg accgtatcaa tggcatcctg cctccgtttg
     2221 taaatttggg agtgcttgga ttgaactatg gtttacaggc ttcgcaattc actgcaacct
     2281 ccaccacagc ggagtgtcag acattatcaa atccgatgta tgtacacagt atccccaaca
     2341 acaatgataa tcaggatatt gtcagcatgg gaaccaactc ggctctatta gcaaaaacag
     2401 tcattgagaa ttcttatcag gtgatggcta tccagttcat gggaatggca caagctatcg
     2461 actacctgaa aatacaggat cgcctaagtt ccaaaagcag gcaggtttat gaagaaatac
     2521 gcagtttctt ccctgtattt accaatgaca cacctaaata taaagagata gaaatgatga
     2581 tagactatct caaaaaagaa gataaataaa atgaaatatg cattagtaac cggaggaagc
     2641 cgaggtatcg gccgtgctgt cagttgtaaa ctggcggaaa tgggctactt tatactgata
     2701 aattatcaga ataacgacgc agaagcggag aaaacgttgc agttagtaca ggaaaaagga
     2761 agtaatggcg agttgatgaa gttcgatgtg accgaccctg ccgctatcac ccttgctttg
     2821 ggcaactggg cttcccaaca ccctgacgaa tatatcgagg tactgataaa caatgcaggt
     2881 atccgcaaag acaacctgat gctctggatg acaggagaag aatggagcaa agtgctcgat
     2941 atcagcctga acggattctt caacgtgaca cagcctttat tgaagaatat gctggtcaaa
     3001 cgttatggac gtatcgtaaa tatcgtgtca ttgtcgggca ttcagggaat gcccggccaa
     3061 actaattact ccgcagccaa aggtggcgta atagccgcta ccaaagcact ggcacaggaa
     3121 gttgccaaga agaaagtaac agtcaatgca gtagctccgg gattcatccg tacggatatg
     3181 acggaaggaa ttgatgagaa cgaatggaag aaacatattc ccgcgggacg tttcggcact
     3241 ccggaagagg ttgccgacct ggtcggtttc ctggcatctc cagcctcatc ctacatcaca
     3301 ggagaagtga tttccatcaa cggaggacta tatacttaaa ataaaagcat agaatagaca
     3361 aaataatgaa aagagttgtt atcacgggaa tggggattta ctcttgcatc ggcaagaatc
     3421 tggatgaagt aaaagactca ctatatcatg ggaaatcggg aattggcata gacccggtac
     3481 ggaaagaatt gggctatttt tctgcattaa cggggatatt ggaacgtccc gacttgaaga
     3541 agttgttgga ccgccgtaaa cgtctctgtc taccggagca gggagaatat gcttatctcg
     3601 ctacattaga agctttccgt aatgcaggga ttgacgagaa ttttctcgaa tccaacgaag
     3661 tgggtatctt gtatggcaat gatagtagcg ccgctcctgt tattaacgca gtggacatca
     3721 ttcgtgaaaa gaaaaacact gcactagtgg gttccggttc tattttccag tcgatgaatt
     3781 ccaccgtgac aatgaaccta tcggttattt tcaaacttag aggggtcaac ttcactattg
     3841 ccggagcctg tgcaagcggt tctcacgcta ttggtatggg ttacctgctt ataaaatcgg
     3901 gattacagga ttgtattctt tgcggtggcg cacaagaagt caatccttat gcagtaggaa
     3961 gtttcgacgg actaagcgca ttttccaccc aggaagcagc ccccgagaaa gcctcgaaac
     4021 cttttgataa acgacgtgac ggactgattc cgagtggagg agccgccagt ctggtattag
     4081 agagttatga atcggctgta aaaaggggag ctcccattct ggccgaagtc atcggttacg
     4141 gtttttcatc caatggagat cacatctccg tgcctaatgt ggacggcccg aaacgttctc
     4201 ttcaaatggc tatcaaagat gcagggattg cactcgaaca gatcagttat atcaatgcac
     4261 acgccacctc aactccggta ggtgacttga acgaggcgaa agccattgcg gaagtatttg
     4321 aagggcatca cccgtatgtg acttccacga agtctatgac aggacatgaa atgtggatgg
     4381 ccggtgccag tgaagtgatt tattccaccc tcatgatgaa caacggtttc atcgctccca
     4441 acctcaattt cgaggaaccg gacgaggcct ctgcacaatt aaatatacct acccaacggg
     4501 taaacctgga atttgatacg ttcctttcca actcattcgg attcggagga accaattcca
     4561 cgctaatcat acgcaaaatc aatccataat ttactaaaga aaacagatat atgacaaacg
     4621 aagaaatcat cgagaaaata agaaccactc tggcagaaga gtttgaagta gacatcgacg
     4681 ttatccagcc ggatgcaccg ttaatggaaa ctcttgaact ggacagcctg gacttggtcg
     4741 atatggtggt actggtagaa aagaacttcg gtttcaacgt aaccggacaa gattttgcgg
     4801 gtatcaaaac cttccaggac ttctacgatc tcgttatcac ccgtatgcag gaagccaagt
     4861 aaatatgtcg acgtggaaag gcaaaacccg gggaggaaca ttcggatact tattctttat
     4921 ttacctgatt aagtatctgg gcattactgc cgcttatata tttctaagtc tggtagtatt
     4981 gtacttcata ccgtttgctc cgaaagccac caaaagcacc tggttttatg cccgccacat
     5041 tctgaaatac aaccgaatac gctctttggg tatgttgcta cgcaactatt accggttagg
     5101 gcaaatcctg attgacaaag tagctattgg caacggaaaa gtcgatcaat accggttcga
     5161 gttcgaacgg tatccggagt tcctgcaatt gctgaacagc gaacagggag tgattatgat
     5221 tggcgcccat gtgggaaact gggaaatagg cgttcctttc ttcgacgatt acggaaagaa
     5281 aatcaatatc gtgatgtatg atgccgaaca tcgtagaatc aaagagatat tggagaaaaa
     5341 tggtcaggac aaggatttta agattatccc cgtcaacgaa gataacctga cacacgtttt
     5401 ccgtattacc gaggcgttaa acaagaaaga atatgtatgc ttccagggcg accgttatct
     5461 gaataaagag aaactgctga caggaacact cttgggacag aaagctcctt tccctgccgg
     5521 tcctttcctg cttggttcgc gaatgaaagt tccggtggta ttctactttg ccatgagaga
     5581 gccgggcaga acctaccgtt ttcattttat aaggacggaa ccagtcatac gaaccaaaga
     5641 aaagaaagca gagacagctc tgctcgaaca atatacggcc gctttggacc agatactgaa
     5701 acgctatccg gaacaatggt ttaactatta ctcattctgg gaaaccacaa gtgacggttc
     5761 gctctcaaag ggttgaaata gaaagatata acaaaataaa gatgcaacag aatcaatatg
     5821 ataaggaacc gttgaccgcg gtagaggcac aacgcctggc acaagaaata gctttcgggc
     5881 ccatcgtgtt tcaggtatca cgccttatgc tcaaattcgg tatttttcag ttactggccg
     5941 acgaacgcgc tggcatgaca caagaagaaa tcagcaaggc ttgtgagttg tcttcttatg
     6001 cgacacaagt attgctggaa gcctcattaa ccatcggtac cgtattgcag cacgaaaacc
     6061 gttaccgcct tgccaaagcc ggatggttcc tgctcaacga caagatggta cgtgtcaata
     6121 tggatttcaa ccacgatgtc aactatctgg gaatgttcca tcttgaagag gctctcacca
     6181 acggacgtcc cgaagggctg aaagtattcg gcgaatggag taccatctat gaagggctgt
     6241 caagtctgcc ctcacaggta caaaagagct ggttcggttt cgatcattat tactcggatt
     6301 gctcgtttga cgaagctttg gcgattgttt tcgcccgtca tcccaagact ttactggatg
     6361 tgggaggtaa taccggtcga tgggcaacca agtgcgtaag ctatgacgac gcggtggaag
     6421 taactataat ggatcttccg caacaattgg agatgatgcg tcaacaaact aaagaactgc
     6481 ccggagcaat gcgtatccac gggtatggcg ccaatctgct cgatcccgaa gttcctttcc
     6541 cgacagggtt cgatgctatc tggatgagcc agttccttga ttgtttctcg gaagaagaag
     6601 taaccagcat actgacccgt gcagcccgct ctatgagccg ggagagccgc ctctatatca
     6661 tggaaacttt ctggaaccgg caaaagtttg acacagccgc ttattgcctg acacaaatca
     6721 gtctttattt cacagccatg gcaaatggta acagcaaaat gtatcattcg gatgatatgg
     6781 aacggtgcat caaagcagcg ggattggaag tcgaaaagat agatgaccat ttaggaatgg
     6841 gacacagcat tgtacaatgc agattgaaat gaacaacagg gaagttatca tacaaggaga
     6901 aggaatactc aatttgattc cacagcgtcc gcccatcgtg atggtggaca gtttctttgg
     6961 tatcgaagag aatcattctt attccggact gactgttact gctgataata ttttctgcga
     7021 aaccagaaaa ctgcaagagg cgggaattat tgaacatatc gctcaatcgg cagcagcacg
     7081 tatcggattt ctttataccc ggcagggtga aaaagtaccg ttaggattta tcggctcggt
     7141 agacaaactt aaaatctacg atttgccaaa gatcgggatg aaactattta cggagattac
     7201 cgttgtacag gaggtattcg acattacatt gatttctgca caagtgaaag tggaagacaa
     7261 gctgatagct gaatgcagga tgaaaatatt tataaaaaaa gaatgaaacg gaaaacgaat
     7321 caacaggttg caactttgac caaccggact accttcagag tgcggttcag cgaaatagac
     7381 tccatgcaga ttgtatggca tggtgagtat gtgcgctatt ttgaagatgg aagagaagct
     7441 tttggcaaac agtatggttt ggattatatg agtatttacc gggagggata catggttcct
     7501 atcgtggatt taacctgtca gttcaaacaa tcactatctt ttggtgaaga agcgattgtc
     7561 gagacgcgct atattgcctg tgaggcagcc aagataaaat ttgaatacgt tatctaccgg
     7621 gctaccgacc aaagtatagt agctaccgga agcaccatac aagtgttcct gaacctgaat
     7681 aaagaattgg agcttatgaa tcctccgttt tatctggaat ggaaaaagaa atggaatatc
     7741 ctttaaatat atacatcaca gcccatacgc tgattagttc gttaggtttc ggcatcccgg
     7801 aaaatctgga ggccatccat aactaccgaa gcggaatccg tatgcaagaa gccggcctaa
     7861 tttccgatca tcccctattg gcgggaatga ttgattctgt ggaactggaa aaacgggcga
     7921 agctgatgca gattacggat tatacccgga tggagcaatt attcatactg gctatccaaa
     7981 aggttatttc tcaatcggga accgacttgc gggagccgga ttgtgccttg ttattatcta
     8041 ccactaaagg aaatgttgat ttattgagtg aattacctgc tgacagtccg gtttttcttt
     8101 ggaaaatggc ggaacgaatc ggagatttct ttggagcggc aaatcaggta gaggtcatct
     8161 ccaatgcctg tatatcagga gtctcggcac taatcgtcgc taagagatgg atagaatcag
     8221 gacgttacaa acgagtgatt gtggcaggtg gggatattct ttctcatttc attaccagcg
     8281 gctttctatc gttccgatct gtcagcgcac acccctgccg accatacgat atacaacggg
     8341 atggattaag tctgggcgaa gcctgtggag ctgttctttt agaaactcaa ggaaacgcga
     8401 atcatattat tctctccgga ggagcaatca gcaatgacgc caaccatata tccggtcctt
     8461 cccgaacagg ggacggttta gctctagcca ttaatcaggc aatggaagaa gccggagcac
     8521 tccccgaaga cattagcttt atcaatgcac acggaacagc tacggtttac aatgatgaaa
     8581 tggaatccaa agccatacat ctggcgggat tagctgcagt tccggtgaat agcctcaagc
     8641 cctatttcgg tcatacatta ggagcttcgg gcattatcga aaccatactt tgcatagagc
     8701 aactaaaaga aggaagatac tacggaactt tagggtatga aacactcggt gttcccatgc
     8761 ctatcactgt ctatgccact catcagccga taccgatgaa atgctgcatc aaaactgctt
     8821 ccggtttcgg aggctgtaat gccgcactgg tattatccct ccccgatgct catctgaaac
     8881 agaaagcaaa ctcgcaggca accgacaaag cgagcgctcc gtcagtttac aaagcggttg
     8941 tggaatcggg caacatggtc acaatcagat caggagcagt agaaagtaaa ggaacaactg
     9001 tattcagctc ttcggaaact gactttgcac cgtttatccg ggaagcatac aagcatctgg
     9061 gagaaaacaa tatgaagttc tataagatgg acaacctctg taagctggga tatgtagctg
     9121 ccgaatattt actgaaagat acaaactacc atccgaaaga gattggaatc attcttgcca
     9181 atgcttcttc ctctctggat acggactgca aacatcaggc aatcatcagt aaagaaggag
     9241 acaaagcagc cagtcctgcc gtgtttgtct acactctccc caatgtagta ttgggagaaa
     9301 tctgtatccg gcacaagatt cagggagaga atacattctt tgtccgtcga caatccgatg
     9361 ctgcctcatt agaagattat gcaaggattg tgatggcgaa aggtaagtta cgcacctgta
     9421 tcataggctg gtgcgaacta ctggacggac attatcaagc agaatttaaa caacttaata
     9481 atatatcaac gatttatgga taatttagat caaaccaaaa gagaactgat ggacgaagtg
     9541 aaagggaaac taatcgaaga gttgaacctt gaagaaatca ctccggaaga tattgacaat
     9601 gaagcccctc tgtttggcga cgaaggtctt ggccttgact ccattgacgc actcgaaatc
     9661 atcctgattc tggaacgcga atacggtata aagatagaga accccagtga aggaaaacaa
     9721 atcttctact cggtacgtac actggcagac tacatcattg ctaatcgcaa agcttaaccg
     9781 atgaagatat acgtcaccgg attgggagtt gtttcgggca tcggtatcgg agtttccgaa
     9841 aatatagaag cgttgagaca aagaaagcat ggcatcggaa aagtaactct ttttccgact
     9901 gctctcgatg tgcccgtatc cgaagtgaaa cgtagcaatg aggaactaaa gaaactgatc
     9961 tctttaccac cgcaacgcac tgtatcacgt acagccttgt tgggaatgat agcagccgaa
    10021 gaagcaatga aagatgcggg actcacacca tcattacgta tcggttttat ttccgccact
    10081 tccgttggcg gcatggattt gagcgagcac ttctatgaat ctttcaagaa gaacccggga
    10141 cagggacggt tacgggaagt aatttcacac gactgcggag ccagcacaga attgattgct
    10201 tcgtatttgg gtatcaatga ttttataacc accatcagta cagcctgctc gtcagcagcc
    10261 aatgccatca tgctgggagc aagaatgatt aaacacgggc tactggatgc tgctatcgtg
    10321 ggaggcacag atgcactttg ccggtttacg ctcaatggat tcaactccct gatgattttg
    10381 gacaaaacac attgccgtcc ctttgaccgc tcacgtaccg gattaaatct gggagaaggt
    10441 gccggttact tagtacttca atcggaaagt tcacttcaaa gaactcctta ttgcgaactt
    10501 agcggttacg ccaatacaaa tgaggcttat catcaaacag gaagttctcc tgaaggggac
    10561 ggtgcctttc tgtcaatgag tgaagctatc gcctccagtg gcatttctcc caaagaaatc
    10621 gattatatca atgtacatgg aacaggtact cccggcaatg atgcgtcaga aggtatggca
    10681 ctccgaagaa tctttggaga acatgttccg ccatttagtt cggtaaaagc ttttatcgga
    10741 cataccttag gagcttccga aggaattgaa gctgtttact ccgttctttc aatagataaa
    10801 gggctgattt atcccaacct gaactttacg gatgcgatgc cggaaacagg actgataccg
    10861 gaaacctctt ttcaagaagg aatccccatc cgacatgtgt tatccaactc tttcggtttc
    10921 ggaggaaacg attcatcgct cctcttttcc gcaacgaatt ttccagcatg aacgcacctt
    10981 taagtattta agcctatgca gccagtttat attcaacgca tcgcttccat tcatccgcca
    11041 aaggatcatt caccagaaaa taatcaccct tatcttcagg cttgcgaacc cgattataag
    11101 gatattatca ccaatgcgac cttgcgcaga cgtatgagcc gtatcgtaaa aatgggggtg
    11161 gcctgcggat tggaatgtat gggtgaacta tctcctgaaa agatacaagg aatcatcaca
    11221 gcaacaggat tgggctgcct gacagatacg gaaaaattcc tgaacaacct attggataat
    11281 gaagagcgga tgctgaatcc tactcctttc atccagtcga cattcaatac aatcggtgca
    11341 caaatagctc tgattcatca aatacatgcc tacaacatga cttatgtcca ccgtggactt
    11401 agttttgaaa gtgctttatt ggacgctatg atgaaaatag gagaaggaag cgagaatata
    11461 cttgtgggag ccatcgatga aatgacagaa accagttaca cgattcagca acgactggga
    11521 atgctgaaag ggatagcagc cggagaaggt gctcaattct tcctgttaag tcgggaagcc
    11581 ggagagcatc cgttggctga aatacaggga atcgaaactt tcatcgggaa acagactaca
    11641 gaagaaatca gctcccgaat catccgtttt ttgcaacgaa atggtttaga atgtcaggat
    11701 attcagtggt tggttaccgg aaaaaacaag aagcaacaca atcaagatga ctctcacgag
    11761 caaactgtcg acaatggcaa ctctatttat gaagagcttg aaacaaacct tttcccggaa
    11821 agtgcttatc ttagttttaa gaatgaatgt ggtgaatatc ctaccgcaac atcgtatgcg
    11881 gtatggaaag cagtgaacga atcggccaac tgcactacct cgacccatat attgatttac
    11941 aatcatcacc actccatcaa tcattcattg attctaatcc ggaaaagcgt atgataatcg
    12001 tttgcctcct tctttgcttg ctcttgctcc tgtcttttct cgtttatgcc tcttatagca
    12061 ttcaatcggg aatttacctc cggtcatttt gcaaaaagca tactgcggaa aagattgtcg
    12121 ccctgacttt tgatgacggc cccgactccc tacagactcc caaagttctg caggtactaa
    12181 aagaatatca ggtaaccgcc tgtttcttct gtatcggtca taaggtaaaa gggaatgaag
    12241 caatcttgca aaaaatggtg gcagaaggtc atctgattgg aaatcattcg catacccatt
    12301 ccggtttatt cccgctatac gggctctcca agatgaaaaa agacttgcaa acttgtcagt
    12361 gtgaactaga acgagtaact tcgcagccgg ttagtttgtt tcgtccgccg tttggtgtca
    12421 ctaatccaac gattgcgaaa gccgttcgac agttaggata tacctctata ggatggagca
    12481 tccgtacact agatacacaa caaccagcac cggataaagt ccttgccagg attcggaaac
    12541 gtcttgaacc gggagccatt attctgttgc acgaccggat gccggacagc gaccagctag
    12601 tgaaacaaat cttggatttg ctgaaagaac aaggatatac tgctgtccat ccggacaaac
    12661 tattggcata aaataaaaaa ggtatgagaa ctttattaat atatttatcg cttttcttct
    12721 tgtcaatagc ctctatccat gcccagagca tgaaaaagat ggcgcaaaag acagagtttg
    12781 aaagccgcct ggcaaaggag gcgcaaaccg tagagtccat cgaaagcgat tttacccaag
    12841 tgaaatatct cgatgtattc gatgagaaag ttacttccaa agggaagttc tactaccaga
    12901 agacccataa aatctgcatg gaatatttcc gcccgatgga ttatctcatc gtgataaacg
    12961 gcagtaagct caaaatcgtt tcggatggca agaaaagtat catgaatctt agttcgaaca
    13021 aaatgatggc acagatgcag gatatgctga ccgcatgtat gataggcgac ctgtctaaaa
    13081 tgtcgtccaa ctacctgctg gagtattttg aagacgcacg atactatctg gttaaaataa
    13141 aaccgaccaa caaagcggta caagcctata ttgccggtat agaaatctat ctggacaaga
    13201 aagatatgtc ggtacacaaa ctccgtctgt ccgaaacagc cacaaactat acagaatacg
    13261 aattctataa taaaaagttc aactccctga agaatgagac gaagtttgcg attcgttagt
    13321 ctgacggctc tgctattctt atggatacag atccagactt cctgctctcc acggatgagc
    13381 ggggaaggaa gtaccgtgcc ccccgctatc gaactaacac aaggagaaag ctcgcaaaaa
    13441 tacaatatcc aactggattt catgaaacat cacatgagcg gtatgctaat agtacgccgt
    13501 atgcctgata acgaaatccg gatcgtagcg tctacctact tcggactaag ccttttcgat
    13561 ttttctcttc gcaacgatca gtttactgtc aacaattgca ttgaacccat gaaaaaggaa
    13621 aaggtgctga aacttctgga gatggatttc agacgtctgt tcttaagtgg gaaagatact
    13681 cgtgtgaaag cgaccaaaga cagtgctact gaaaaaagaa ccagtggaaa aggctttgga
    13741 aagtcagtgg tctacatcac tggcaatact ccgggcgatc ccgcacaaat aaaaatcaaa
    13801 catccgtgga ttcggttaac gatccgtctg gacaaactat ctaaagagat ttaatatatg
    13861 ctacttgata acttctatac catcctttcc tccgaatcat cggactcaac gatctggact
    13921 atccagataa agttgaatcc cgggcatcct gtttatcagg gacatttccc cgaacatccg
    13981 gtagttccgg gagtttgcct gttacaactt atcaaggaat gtgtagaaga tattcgccag
    14041 caaaaattgc aagtaacaca agtgtcttcc tgcaagtttc tttcggctat caatcctata
    14101 gaaacaccgc acatttcggt ggcactgact tttaaagaga cagaagaagg tacacttcag
    14161 ttgcaagcgg aagggagtgt aaagaaggaa gctgtaaaaa agagtacagt gaaagagagc
    14221 actgtagagg aaaataccgt aaaggacgaa tgtttcatca aactaaaagc tgcacttacc
    14281 ccgacagtat gaaggaacaa ataagtacag cctattggca cgagaagttg aaacaattag
    14341 ggatcatcgt tatcatccca agttacaaca atggaaagac actggcggac gtcatagaaa
    14401 gtgtacgttt ctacgccccc gatatccttg ttgtcaacga cggttctaca gatgaaactg
    14461 ccgaaatact tagccgagaa tctaacttac atatcatcac ccaccctgtc aatcaaggaa
    14521 aaggagtagc tttgagacat ggactatcct ttgccaaaaa gcaaggattc cggtatgcaa
    14581 tcaccattga ttctgacgga cagcatttcg cttcggatat ccccacattg atcgaagcca
    14641 tagaaaaaga accggacaca ttattggtag gtgcccgtaa cctcgcctcg gacaatatgc
    14701 cgggaaagaa tacatttgcc aataagtttt ccaacttctg gtttaccctc gaaacaggta
    14761 tcaaactgca agatacacaa tccggctacc gcctgtaccc catccaacga atgaatgtgg
    14821 acaagtggta ttacaccgcc aaatacgaat ttgagttgga agcacttgtc tttgcagtct
    14881 ggggaggcat taccgttaaa aacattccgg tacatgttta ttatccgcca caggaagagc
    14941 gggtttctca tttccgaccg ttccgtgatt tcacccgtat cagtatcctg aacacagtac
    15001 tggtgctcgt cactttcctt tggatcatcc cccgaaactt cttccgtaaa ctgacttgga
    15061 agaactgcaa gcagtttttc tcggatcatg tcacccactc ccccgaatct aatctgcgga
    15121 tcacggctgc catcacactc ggcgtattca tgggtatcgt tccggtatgg ggatatcaaa
    15181 tgctaatcac gttatttctg gcacatttgt tcagactgaa taaagtcata gctattgtag
    15241 cagccaatat cagtatccct ccgatgattc catttttgct gtacggcagt tacgtaaccg
    15301 gctgcaaagt gctgggagat cctgtcaatc tgcatttaaa cgaactttct tttgaaaatg
    15361 taaaatcagt catagagcaa tatttaatag gaagtgttat ctttgcagtc gtatgcagca
    15421 tactggcagg aaccatcgcg ttcattctgc tcacggcgtg taggaaaaaa aagatatgac
    15481 ccagtttttt atcggactat atgattattt cgagaggcac aagattctgt tctatttgtc
    15541 actcatcagt tgtgtcctgt taatgggatt ctttgccctg caagtaaggt tcgaagagaa
    15601 catcacacaa tttttccccg acactaaaga ttcccagaac acaatcaaag tattcgacaa
    15661 tctcaagatt aaggataaga ttatcattat gttatcctcg gcagatacct gccaccgcgt
    15721 agaacccgac tccctgatag aagcagccgg acaactgcaa caaaccctga ctgaaaaaac
    15781 cggaggaaaa ctgattaaag gaattttcgc acaggtagac caaagcctca tccaaggagc
    15841 cacagacttc gtttatgaac atcttccgct tttcctgacc gatacggact atcaacgctt
    15901 cgattcctta ctgacggata aagggataca ggctgccatg cagaagaatt ataccaacct
    15961 cctctctcct gccggaattg cattaagaag ttatattctc cgggacccgc tcggactggg
    16021 aagcgaaacc ctgaaacatt tgcaagattt ccagttggaa gccaactacg agatttatga
    16081 cgaacatatc ttctccaaag acggctccac cttacttatg ttcattaccc cggtattcag
    16141 tacaggcagc accggaaaga acgacgaact gataaagatg ctcgaagaag agctcaagca
    16201 cgtacaggga gaatctccta ccattcgagc tgaatatttc ggcggtccct ccgtgggagt
    16261 ctacaacgcc cgtcagatta agaaagatac catcctgacc tcctccctgg cattgcttat
    16321 catcattgta tttatctcac tcgtttttaa acgaaagaga tcgataccgt tgattattac
    16381 tccggtactg ttcggaggat tatttgccct gtttctcatt ttctttatta aaggaagtat
    16441 ctccgccatt gcagtgggag ccggttcggc agtgatgggt attgcactaa gctattccat
    16501 tcacatgctg gcacatcaga accacgtttc caccgtacaa caacttatta aagagatagc
    16561 ctatccgctt acggtaggta gtttcaccac catcggcgca tttctgggat tgatattcac
    16621 cagttccgat ctgttacgcg acttcggttt gtttgcctct ctggcattgg tgggcaccac
    16681 cctcttctgt ctcatttacc tgcctcattt tctgaaagga caggcagacg ttaaacaggg
    16741 acgcatacta cgcatcatcg agaaaataaa cgcttattct tacgaaaaga ataaatggct
    16801 ggtaggcggc atcctcctca ttacagtgat ctgtttgttt acttcgcaaa aggtaggctt
    16861 caacaacgat atgatgagtc tcaactatga gccccgccat ctccaacaat cagaagaaaa
    16921 attactgcaa ctcttcgaca acgacgaaaa gaccgtgctt tttgtcagtg tgggcaaaga
    16981 catgaatcag gctaccgaaa cttatgcaat gaccaatcag aagttatcgg cactgaaaga
    17041 gcagggactc atcaaagagt atgcctccgc ctcacagttt ctgatctctc cgcaagagca
    17101 gcagaaacgc ctgaagaaat ggaaagatta ctggacggat gaaaaacagc aacaagtccg
    17161 taaacagctg gaaacagctg ccgccgaata tcgtttccgt tcgggaagct ttgattcttt
    17221 ttatcaatgg atgaaccaac ctttcggtga atatcattac accgcgcaag gagacgattt
    17281 atccggcaag ctattgaatg aatggcaaac ctctgccgat tccatcacca tgcttatcag
    17341 ccagatacgg atcagcgaac cgaataagga agctgtgtac caaaacttta ataaagaccc
    17401 gaatgtagtc atcttcgacc gttcctactt tgccaacaaa tgggtatcgg ccatcaatga
    17461 cgacttttac ctgattcttt acatctcttc tttcctgata ttctttgcac tatggttctc
    17521 ctacggacgt atcgagctta ccttgatgag ttttctcccg atgctaatca gctgggtaat
    17581 catcttagga ttaatgggaa ttctgggaat tgagttcaat attatcaaca tcatcctgtc
    17641 cacctttatc tttggcattg gagatgactt cagtatcttc attatggacg ggctacaaaa
    17701 caaataccgt acaggtcaga aggtgttgaa ttcccataaa acagccatct tcttctccgc
    17761 cttcaccaca gtggtcggta tgggagcact tgtgtttgcc aaacatccgg ctttgcaatc
    17821 catttccctg atttccattc tgggtatgat agcagtggta ctggtggcct ataccattca
    17881 gccactcatt ttccggttct tcatcgcagg ccccgcttcc aaaggattgc cgccttatac
    17941 gcttatcgga ttgatacgta ccgtgttgct cttcctgctt ttctttatcg gctgcatcgt
    18001 cctccgtata ttgattattc tgctttatcc ggtgcctgtg cgcaaaagca gcaagcagcg
    18061 tttggtgtgc cgcctgatac aaatcacctg caaaggaatt ttgctactgg ccaccgccgt
    18121 caaaaaagaa catatcaaca aagccaacga acgcttccgg catccggcaa ttatcattgc
    18181 caaccaccag tcgttcatcg acattctggt attgctgtct ctttcatcta aaatcctgat
    18241 ggtaaccaac cattgggtat ggcactctcc tttcttcgga gccatcattc gttatgtcga
    18301 cttctattat ataggcgaag gatacgagca atatatggaa cggatgcgga aaaaagtgaa
    18361 ggaaggctac tccatcgcca ttttcccgga aggcacacgt acctataacg gaaagatgaa
    18421 acgtttccac aaaggagcat tctatctggc agaagcattg aaactggata ttctcccgat
    18481 cctgctttac ggtaataaca aaatcattgc caaagcacaa cctttcaata tccggaaagg
    18541 aatcatctat acggaaatac ttccccgtat accattagac gatctgtctt tcggaagtac
    18601 ttatcaggag cgtaccaaac gcatatccgc ttacatgaaa gaggtttatg cccgtatctg
    18661 ccgtgaacag aacacgacgg acaatcctgc attctacgaa gctcttatcc agaactatat
    18721 ctataaaggt cccgtcgtag aatggtatat ccgtatcaaa gtaaaaatgg aaaagaatta
    18781 ccggctattc aaccggttga ttcccgtcca agggcaaatc acagacatcg gttgcggctt
    18841 cggcccgtta tgctatatgc tgtctctgct ttccgaggac cgggaaatcc tgggtattga
    18901 ttacgatgaa gacaagatag cgctggcgca gcacggatgg ttacgcaacg agcatctcca
    18961 gttcaagcat ggcaatgcat tggaatatcc cctgccggaa agtgatgtct ttatcctgaa
    19021 cgacatgctt cactatatga gctacgaaca tcaacaaacc ctattgttga aatgtgccgg
    19081 tcgcttacgt tcacaaggaa tgattatcat acgcgacgga aattcagcca acgcttccaa
    19141 gcaccggtta acccggttca cagaattact atccacccgt attttcaact tcaaccggac
    19201 gaccggagag ctgtatttca ccactgaaac ccaattacgg gaaatagcag tcgcctgtgg
    19261 aatggctgtc gaaatcattc ctaatgacaa atatacatca aacaccattt acatatttag
    19321 aaaaccgaat tagtatgagc aaatatgaca tcatcattat cggcagcggc cttggcggac
    19381 tggaatgcgg agcgattctt agcaaagagg gattcaacgt atgcgtagta gaaaaaaatg
    19441 cgcaattcgg cggatgcttc cagacttacc aacgaaaagg gcatctgttg gatacgggta
    19501 ttcattatgt aggaagcctg gatgagggtc aagtgatgaa ccagtatttc cgctatttcg
    19561 gtatcatgga caagctgaaa ataaaacgct tggacgatgc tgcttttgat acgatctact
    19621 ataaaggaaa aacatacgat tatgcaatgg ggtacccgaa gtttattgaa accatctgcc
    19681 gttccttccc gcatgagaaa gaaaacttga aatgctatgc cgaacagctt caggctgtcg
    19741 gaaacctgat tagcgtagac cacctgaaac aaggcacact cgctttagag ggtatgaaat
    19801 acttttgtac ctctgccgcc catctgattg cggatatcac tccggacccc gccttacgaa
    19861 atgtactggc aggttcagct ttactctacg gaggtttgaa agatgtatcc actttctacc
    19921 agcatgccat gattaaccac tcctatattg aaggtgccta ccgttttgta gacggaagta
    19981 tgcaagtcag tctggagcta atcaatgtaa tccgggcaaa cggagggacc gtgctcaata
    20041 acagtgaagc cacccgcatc atcgttgaaa acgaaaaggt acaaggggtt atcatcaacg
    20101 gagaagagcg actggaaagc gacttcgtca tctccaatat gcatccccaa cggacattgg
    20161 agatactgga taaaaaccgt agcatcaaga atgcctatat ttcccgcatc cgttcgttgg
    20221 aaaataccta cggcatcttt acgctctacc tggtaatgaa gaaaaaaagc actccctatc
    20281 agaaccgcaa cctgtatctg catgcgaaca ataaagtgtg gtatgataaa ctgctctatc
    20341 cgggacggac caccaactgt atgatttcca tgcaagcgtc ttccgaggac agtcaatatg
    20401 ccagtgtcat ttccatcctg acaccgatgt atatagatga actgtctgcc tggaaggaca
    20461 cgactcccga acatcgggga gaagactacc aatccttcaa aaaggagaaa gcagaacaga
    20521 ttctccgctt catccgagga catggcattg acctttcaga aaacatagaa gagatgtata
    20581 ccactactcc attaagctat cgcgactata caggaacagt ggatggttcc gcgtatggga
    20641 ttatcaaaga ttataaatgt ccgcaaattg gtttcgtatc tacaagaagc cgcttgggaa
    20701 atctctttct caccgggcaa aacctgaatg tgcatggtgc attaggggta acactaactg
    20761 ccatgctgac ttgtgcggag tttgtaggac aagaatatct ggctaaaaaa gtaggaaatg
    20821 catagaatag tcaaaaagac actccaatac acgggcttcc ttttcctgtt gctcattgtt
    20881 ctattgatag ccggaatcag ctatctctac ttttctgcgg atatgcaaac gcccaaacat
    20941 gagcaaagca tgaccacaga caaagtgatt gatatagaca gtctccacct ccggcattat
    21001 ggagataact ttctccggca cagcgacagc ggcttatggg aattgtttgt gaaaggggat
    21061 gctttccaga gaggagaagc tatcgggcaa ctgtcttccg acctgctcca ccatcaagag
    21121 aaagtgttcg tggatcagat tcgtgagatt gttccttcag acagttatct gaaattcctc
    21181 cggttcttca ttgtattatt caaccgtaat ctgggtgaga acgtcctcga agaataccgc
    21241 gacgagatct acggaatctc gctatcatgt acacatgagt acgacttcat cggcactcct
    21301 tacgaacgcc agttgaatta ccattcggcg cacgacctgg gacacgccat gcaggattat
    21361 atgttagtgg gatgcagttc gttcgccact tggggaacac aaagtgcaga ttcatccctg
    21421 ctgattggac gtaacttcga tttctacgtt ggagatgcct tcgcagagaa caagcaggtg
    21481 gctttttatg taccggagca aggatacagg tttgcttctg tgggatggcc gggtatgata
    21541 ggagtgttat ccggcatgaa cgagacaggt cttaccgtga caattaatgc tgccaaatct
    21601 gctgtcccga caggttccgc tacccccatt tccatcctga ccagagagat tctgcaatat
    21661 gcagccacta ttgatgaagc ctttgccatc gcccaaaaac gggaaacatt cgtctccgaa
    21721 tccatattga taggttctgc caaagacggc aaggccgcga ttatcgagaa atctccggag
    21781 aaaacagtgc ttttcaccgg aaaagaagcc aatcgactca tctgcaccaa ccattaccaa
    21841 tcggaagaat tcagcaagga cgaacgaaac atggaaaata tccgcacttc cgacagccca
    21901 taccgttttg cacgattaac ggaactcatt aatgaggatc ttccgataga tgtctccaaa
    21961 gccgcctcta tcctgcgtga ccacaaaggc ttgcaaaaca cagacctggg actggccaac
    22021 gaaatggcca tcaatcagtt tattgcccat cattccgtca tcttccagcc ggaaaaacgg
    22081 ctgatgtggg tatctacctc tccctggcaa tgtgggaaat acatagccta tgacctgaat
    22141 aagatattca aggacacgat tgattggcaa cacgaaatat acagttccgc tctgaccatt
    22201 ccggaagaaa aattcatcga cacaccggag ttccagcatc ttctcactta taaaaaactg
    22261 actccgcttt tattgaagaa aatcagaaaa aaggaaaaga tagaggaatc tgttttaaaa
    22321 acataccaag cctccaatcc ttccctatac tatgtatatg aagtaatagg agattactac
    22381 gagaccatgc agcaacctca acaagctatt gcatactggc aacaggcatt gaagagacct
    22441 attcccaagt tgcaagagaa agaacgtatc cagcaaaaaa ttcaaaaaca atccaaagat
    22501 ggaaaagaat cctgaaattc agttccgctc accggaagat atcaaaagct atcaggaaga
    22561 acagttagcc aaagcgttag cctacctgca agcacattcc aagttctatc aacagatgtt
    22621 tgccgaacat cacattgata tcaatcaaat aaagacgatt gaagacttgc aacagattcc
    22681 tgtcactacc aagacggact tgcaactcca taacgatgat ttcatctgcg tagacaaaga
    22741 ggaaattatc gactatgtga cgacttcggg cacattggga gatccggtca ctttcgttct
    22801 cacctctgaa gacctggacc gtctctctta caacgaatac ctatctttca ccaccaccgg
    22861 atgcaccaag caggatattc ttcaattgat gactaccatc gaccgccgtt tcatggcagg
    22921 cttggcttat tatatgggag cccgcgaact gggtatggga gtgatccgtg taggcaacgg
    22981 catcccggaa ctgcaatggg acacgattcg acggatacat ccgacttgtg gaatggtggt
    23041 cccctctttc cttatcaaac tgatagagtt tgccgaaaag aatcatatcg accataatac
    23101 ctgttccatg cagaagtgta tctgtatcgg agaagcattg cgcaatcagg aattccagtt
    23161 gaatacgctc ggacagaaga tacacgataa atggcctgcc ttgcagttgt attccactta
    23221 tgcctccacc gaaatgcagt cgtcctttac cgagtgtaat gaattccacg gaggacattt
    23281 gcaaccggaa cttatcattg tagagtttct ggatgataac aatcgtcccg tggaagaggg
    23341 agaagcaggg gaagtaacga tcacgacgct cggagtcaaa gggatgccgt tgctccgttt
    23401 caagacaggc gatatttgct accaccacac cgagccctgt ggttgcggga gaaataccat
    23461 ccgcctaagc tccatcctcg gccggaaagg gcaaatgatt aaatacaaag gaacaacgtt
    23521 atatccgcct gcattattcg acattctgga taatatacct tcggtaaaaa actatatcat
    23581 tgaagtttat accaatgaat tgggaacgga tgagattctg attcgtatcg gaagcgagaa
    23641 ccgtagcgaa gcctttgcca aagagattaa agatctgttc cgttcgaaag tcagagtggc
    23701 gccaagcatc aattttgaat cggcagagta cattgccaag atacaaatgc ctccgatgag
    23761 tcgaaaaacg ataaaattca ttgatttacg ataattattt tctacttttg gaagttagta
    23821 accaactata tcactttaac attaacgtat atgaaaaaac ttattctatt cttattcttg
    23881 agcacgagcc tgttctgttt cggacaaggc aagagtgcat tgaaagacat tcagtctatt
    23941 aagttctatg gggtagacta ctcccaagta aaagttttcg gtgcagatga atcaccggta
    24001 caattcaaag atgctttcag acgtatcaat gagctgttca tcacagaagc taagaagtat
    24061 aacgtaggaa aacaattgaa aaaagaggtg acagagattt cactggatgc cgtcaatcag
    24121 gtgaacgaaa acatcgacct ggccgaacta atgactgcta aaagagaata tactcttagc
    24181 aaagagcaaa tcaaagcagc catcaacgca ttgcctatcc agaaaacacc cggagtaggt
    24241 atggtgttta tcgcacagtt cctggacaaa tcaaacaata gaggtacgta tgaagtcgta
    24301 ttcttcaata ccgaaacaaa ggaaatcatt gaagaatgga ttaccgacgg caaggcacgt
    24361 ggtttcggat tgcgcaacta ttgggcaggc tctatctata gcgcactcaa gaaactataa
    24421 acaataaaat acaagtatga gaaaactact attagtactg accttattat taagtatcag
    24481 tacgtatgtc gcagcacaga attacacaga agtagtgtat ttaaagaatg gcagcattat
    24541 taaaggagta atcattgaac aagtgcccaa tgtctcttta aaaatcaaaa caggtgatgg
    24601 cagcctcatc atctgtcaga tgagtgatgt gactaaaatc acaaaagaag agcggtacac
    24661 aagagattat cgtaaggata ccaacgaccg caaagccgca agaaatacat taaaaggcta
    24721 taagggtttc gtagactttg catatattgg cgatgtgagc gactacaatg cctctaaaat
    24781 tgaattatca accacacatg gttatcaatt caacaattat ttctttgtag gtggtggcgt
    24841 tgctttcaac tactataccg atgcagatct ttatgcagcc cccatctatg ctaacttcag
    24901 agctaacttc atcaacaaaa aagtgactcc gttcgccgac gtaaaagccg gatattctgt
    24961 aggagacata gaaggagcgt atgcttcgat aggagtagga gtgcgttttt ctttaaaagg
    25021 gaaaaaggcc ttgaatttag ctttgatgta taacttccaa gattatgacg ccacaacaga
    25081 ttatagttac agctatggag ggcattatta tcataacagt tggaatgata catgggagtt
    25141 acatggagta ggagctagat tcggatttga attctaaccc cgttgtttac aacagacaaa
    25201 caaacgatta atcaaattcg aagatgaaaa agaccatcac aacacttcta ctattaagtt
    25261 gcattactac attctcattt gcacaaagta ttgtcatgac ttccggtact attgacttca
    25321 tcaaggacca gcaagtgata caatttactt tctcttacga tgaaatgctg gtaggcaaac
    25381 tgacagaaaa cgaatatgta gaaaaaaaga gttctgaata caacgctaaa gaagagggca
    25441 aaggagacca atggaaagcc gcctggtatg gtgaccgtaa agaacggttt gaaccaaagt
    25501 tcctggagct ttttgataaa tatatgagtg aggtaggcat cactgcaggt tcagaaggtg
    25561 ctcaataccg gattgaaatc aataccgatt tcaccgaacc gggttggaac gtgggtgtca
    25621 tgcgccaaaa tgcgtctgtc gatctaagtt gcaaggtgaa gaagattgaa accggcgaac
    25681 aagtagcctc catcaaaatt cgtaacgctt ctgccaacaa cttttggggt actgatttta
    25741 cttccggata tcgcgtccag gaaacgtatg ccaaagcagg aagagagctt gccaagttct
    25801 ttatcaaaaa ggcgaagttg cgcaagataa aagactaatg accttattac ttcagaaggg
    25861 tatggaaatg aattaaatct gtttgcaata cagataaatt tcctacccta ctattgcttt
    25921 tcactaatta attttgtatc tttagtaatt ttcatccttt tggagatagc tagtcacctt
    25981 atagaatgat aaatgtcacc ctataaggtg acatttgtct ttttacaaag tgcccattgt
    26041 cccgttacaa cgggacgact acccgactgc acaaaaagtc actagtttct gcactgaaaa
    26101 gtcttaatct atgcactgaa agaccttaaa tacaatgatg aataatggaa acgttattga
    26161 tgcgttatat aaagaatatt aggaactttc cgttctccgg catggtcaaa ccgcccattg
    26221 tcacaaggat aattaacgac tccattatcc gatgcaccgg acaaccaaag agtagtagat
    26281 ccacctccat ccaaatttaa tgcatcctca cctcctaaaa cacgaatcag atgtgccaat
    26341 tccgggatat tcactcctcc tgcttgttca ggaaaacgcc cgtctaccgt tatcaacagt
    26401 atttttccat ccttagtagt agcaacagca ctacgagggt gcttcgtccg gataaaattc
    26461 ggttcacacg agttccaatc acaaacctgt ccgtctttca acattaacgg accggaagca
    26521 agtatggtac ctgcttcttc cttatactcc ttttctgttt gcctgttcca gggaattaac
    26581 ttcatttttc ccttatgtag atgtatggct ccagtaacac gccatttaga ttcactcaaa
    26641 gtggtcgtat caacgacctg gtcaccaact ttcagaaaac aaaccgaatt tccccgcttc
    26701 atatcaaagt aggaaccatt aatggctgca atggcatgat gttcagaagc aatccgactc
    26761 gtctccttca tttcacccga aaccgctaca tcaaccttca agcctgcgcc gggatcaact
    26821 tctatcagac taacagactg gggtccctga tacaatcggg ggatagaagc atacttatga
    26881 ataagtcctt tttgaggact ttccaccttc cattgggcag agacaattgc cagtgaatcc
    26941 gatactgttt gcccttttat tattccgata gagcataaaa tcaggatagc aattaacaag
    27001 tttcttttta tcatagacag agaaatgaat catttaagcc gctaaagcta gtcaataatc
    27061 aacattcatc caaagattcc cgtacttttc cactctctca ctccattttc tctatcggcc
    27121 cttctctact atccagataa tcaatatcct ccgacgactt ccgatacaga atgaccagta
    27181 gccccttaag ctaacttttg gcagcttctt acttttaata tggtagcgtt tttcctgtct
    27241 tcgttttcta tggtcttgaa atattttcgt cttatctact atacacttcc gctttttttc
    27301 gtacttttac cccttgttgg aaagaagtgc cttttcaacc cttgagaaca gaaaaagaaa
    27361 aaacaatata taaaatgaat cacaaatgga attatcgacc cattacaccc gaacaggcag
    27421 agacaagcca gacattggcc caggaactag ggattagccc gatacttgga caacttttgg
    27481 tgcagcgggg aattacgaag gcagcagatg ccaagaagtt tttccgcccg caattgcccg
    27541 acctgcatga tccgttcctg atgaaggata tggatattgc agtagaacgt ctgaacaggg
    27601 cgatgggaaa gaaagaacgt attctaattt atggagatta tgacgtagac ggtactactg
    27661 ccgtagcatt ggtctacaag tttattcaac agttctattc gaaccttgat tattacatac
    27721 ccgaccgata caatgaaggg tatggcattt ctaaaaaagg agtggactac gccgcagaaa
    27781 ccggtgtagg attgattatt gtactcgatt gtggaattaa agcagtagaa gaaatcactt
    27841 atgccaaaga gaaagggatt gatttcatca tctgcgatca tcatgtaccg gatgatgtgc
    27901 ttccgcctgc cgtagctatt ctgaacgcca aacgcctgga caatacgtat ccgtacactc
    27961 acctttccgg ttgtggagtc ggtttcaagt ttatgcaggc attcgctatc agtaacggta
    28021 tcgagttcca ccacctgatt cctttgctgg atattgtagc tgtgagtatt gcatcggaca
    28081 tcgttccgat tatgggtgaa aaccgtatcc tcgcctacca cggtctgaag caactgaaca
    28141 gtaacccgag cattggcatg aaggctatta tcgacgtatg cggactttct gaaaaggaaa
    28201 tcaccgtcag cgatattgtg tttaaaatcg gaccgcgcat caatgcatca ggacgtattc
    28261 aaaacggaaa agaagccgta gacctgctga cggaaaaaga tttctcggta gcacttgaga
    28321 aagccggaca aatcaaccag tacaacgaaa cccggaaaga cctcgacaag agtatgacgg
    28381 aagaggcaaa caacatcgtt gccaatctgg aaggattagt ggatcgccgc tccatcgtgc
    28441 tctacaacga agaatggcac aaaggcgtga tcggcatcgt agcttcccgt ctgacagaag
    28501 tgtactaccg ccctgccgtg gtactgaccc ggacggatga tatggcaaca ggctccgcac
    28561 gttcagtttc cggcttcgac gtatataaag caatcgagca ttgccgcgac ctgctggaaa
    28621 acttcggggg acatacatac gccgccggac tgtcgatgaa agtggagaac gtgaatgcct
    28681 ttaccaaacg attcgaagaa tacgtttcac agcatatctt accggaacaa accagtgccg
    28741 ttatcgagat tgatgctgaa atagatttca gggatatttc atccaagttc ttcagcgacc
    28801 tgaaaaagtt caatcctttc ggtcctgata acacgaaacc tattttctgc actcatcatg
    28861 tttatgatta cggaacaagt aaagtggtgg gacgcgatca ggaacatatc aaactcgaac
    28921 tggtcgataa taaatcgaat aatgtaatga acggtatcgc gttcggacag agctcacacg
    28981 tacgttatat caaaacaaaa cgctcgttcg acatctgtta caccattgaa gaaaacacgc
    29041 acaagcgtgg tgaagtacaa cttcaaatcg aggatataaa gccgattgaa taagtatcag
    29101 gagatattaa aacaatattg gggatatgac tccttccgcg acttgcagga ggagatcatc
    29161 accagtatcg gcgaaggcaa agatacactg ggacttatgc cgaccggagg cggtaagtcc
    29221 atcacttttc aagtgcctgc tctcgcccag gaagggattt gcattgtcat tactcctctc
    29281 atcgccctga tgaaagacca ggtgcaaaat ctgcgtaaac gcggcatcaa ggcgcttgcc
    29341 gtctattcag gcatgacacg gcaggagatt ctcactgctc ttgaaaattg catcttcggt
    29401 aattataaat tcctctatat ttctccggaa cgtctggaca cggacatatt ccgtaccaaa
    29461 ctgcgatcaa tgaaagtctc catgattacg gtcgacgaaa gtcactgtat ctcacaatgg
    29521 ggatatgact tccgtcctgc ttacctgaaa attgccgaaa tacggacatt gctaccggga
    29581 attccggtac tggcacttac ggcgaccgcc actccggaag tagtgaagga tattcaagct
    29641 cgcttggatt tccgtgaaga gaatgttttc cgcatgagct tcgaacggaa aaacctggcg
    29701 tatatcgtcc ggcaaacgga taacaaaact caagagctgt tgcatatctt acgaaagata
    29761 cccggcagtg ccattatcta tgtccgcaac agacgacgca ccaaagaaat caccgagtta
    29821 ctggtaaacg aagatattac cgccgacttc tatcacgccg gactggataa tgccgtaaaa
    29881 gacctccggc aaaaacgctg gcaaagcgga gaagtccgtg taatggtagc gacaaatgcc
    29941 tttggaatgg ggattgataa acccgacgtg cgtatcgtat tgcatctcga tctccccgac
    30001 tctctcgaag cttacttcca ggaggccggt cgtgcaggaa gagacggtga aaaagcgtat
    30061 gctgtgatct tatacaccaa aacggacaga acgacgctgc acaggcgcgt tgtggatact
    30121 ttccccgaca aagagtatat tctcaatgtc tatgaacatc tgcagtatta ctatcagatg
    30181 gcaatgggcg acggtttcca atgtgtccgc gaatttaatc tggaagagtt ctgccggaag
    30241 ttcaaatact tcccggttcc ggtggacagt gcgctgaaaa tactgactca agccggttat
    30301 ctggaatata cggacgaaca ggataatgcc tcccgtattc ttttcacgat tcgccgggac
    30361 gaactataca aattgcggga aatgggaacg gaagccgaag cactgataca gacgattctc
    30421 cgctcttaca ccggagtatt caccgactat gcctatatca gcgaagcaac cttgtccata
    30481 cgtaccggac tgacccgcga acaaatttat aatatactgg tcacgcttac caaacgtcgt
    30541 atcgtggatt acattccgca caaaaagaca ccttatatta tatacacccg cgaacggcag
    30601 gaacttcgtt ttgtgcatat tcctccttcc gtctacgaag aacgcaaagc ccggtatgaa
    30661 gcccgcatca aggcgatgga agagtatgtc acttcggaga atgtgtgccg gagccggatg
    30721 ctgctccgtt acttcggaga gaagaacgag cacaactgcg gacaatgcga tgtttgtctt
    30781 agtcaccgtg caactggtgc cctgacagag aattctttcg atttcgagga actgaaaaag
    30841 aaaatatcag aattacttac ccagaaaccg ctgacaccgg tagaaatagc cgataagata
    30901 gaagcggaga aagagagcat cagcgaagtc atccaatatt tattggagga aggtgaatgg
    30961 aagatgcagg a
//
