LOCUS       c00058_gnlPro..        13274 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|BKBIDGBN_58.
ACCESSION   c00058_gnlPro..
VERSION     c00058_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-05 01:13:43
            Original ID  :: gnl|Prokka|BKBIDGBN_58
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13274
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13274
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[257:6339]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      258..6339
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..13274
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..13274
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             258..2060
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ILVD_EDD"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg58_1"
                     /sec_met_domain="ILVD_EDD (E-value: 1.7e-219, bitscore:
                     718.9, seeds: 918, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKHQLRSSFSTQGRRMAGARALWTANGMKKEQMGKPIIAIVNSFT
                     QFVPGHVHLHEIGQFVKEEIEKLGCFAAEFNTIAIDDGIAMGHDGMLYSLPSRDIIADS
                     VEYMVNAHKADAMVCISNCDKITPGMLMAAMRLNIPTVFVSGGPMEAGEWNGQHLDLID
                     AMIKSADESVGDKEVAQIEQHACPTCGCCSGMFTANSMNCLNEAIGLALPGNGTIVATH
                     ENRKKLFEDAARLIVENAFRYYEEGDESVLPRSIATREAFLNAMTLDIAMGGSTNTVLH
                     LLAVAHEAGADFKMDDIDMLSRKTPCLCKVAPNTQKYHVQDVNRAGGIIAIMDELAKGG
                     LVDTNVRRVDGMTLAEAIDRYSITSPDVCKEAIKKYSSAAAGKFNLVLGSQNASYQELD
                     TDRATGCIRDLEHAYSKDGGLAVLKGNIAQDGCVVKTAGVDESIWKFTGPAKVFDSQDA
                     ACDGILGGKVVSGDVVVITHEGPKGGPGMQEMLYPTSYIKSRHLGKECALITDGRFSGG
                     TSGLSIGHVSPEAAAGGNIGKIKDGDIIEIDIPNRSINVKLTDEELAARPMTPVTRNRE
                     VSKALKAYASMVSSADKGAVRLID"
     CDS             2152..3903
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg58_2"
                     /sec_met_domain="TPP_enzyme_C (E-value: 7.6e-48, bitscore:
                     151.4, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MADNNKKSNFSSLSQGEGRGEALITGAEALMRSLEHQGVKTIFGY
                     PGGSIMPVFDALYDHRKELNHILVRHEQGATHAAQGFARVSGEVGVCLVTSGPGATNTI
                     TGIADAMIDSTPIVVIAGQVGTNFLGTDAFQEVDLVGITQPITKWSYQIRRAEDVAWAV
                     ARAFYVAKSGRPGPVVLDFAKNAQVEKTEYAPTKVDYVRSYLPVPEMEPEAIRQAAELI
                     NGAERPLVLVGQGVELGEAQQELRAFIEKAGMPAGCTLLGLSALPTNHPLNKGMLGMHG
                     NLGPNINTNKCDVLIAVGMRFDDRVTGKLETYAKQAKIIHFDIDPAEIDKNVKTDVAVL
                     GDCKETLAAVTQLLEPANHQEWIDSFRQYEEVEEEKVIRPELHPAGKALSMGEVVRAVS
                     EATHNEAILVTDVGQNQMMSARYFKYSKERSIVTSGGLGTMGFGLPAAIGATFGRPDRT
                     VCVFMGDGGLQMNLQELGTIMEQKAPVKMILLNNNFLGNVRQWQAMFFNRRYSFTPMMN
                     PDYMKIASAYDIPARRVMTREELAKAIDEMIATDGPFLLEACVEEEGNVMPMTPPGGSV
                     NQMLLEC"
     CDS             3936..4496
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg58_3"
                     /sec_met_domain="ALS_ss_C (E-value: 5.4e-20, bitscore:
                     60.8, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKKLYTIIVHSENFAGLLNQVTAVFTRRQINIESLNVSASSIKG
                     VHKYTITAWTDKDTIEKVTKQITKKIDVLQAHYFTDDEIYQHEIALYKITTPTLEEKPE
                     VSKVIRKYNARIVEVNAVFAIVEKNGMSEEITNLYEELRQLDCVLQFVRSGRVAITTSC
                     FERVNEYLADREAKYRQSKHQEL"
     CDS             4493..5245
                     /locus_tag="ctg58_4"
                     /transl_table=11
                     /translation="MMSENNKIGTYKFVAEPFHVDFTGRLTMGVLGNHLLNCAGFHASD
                     RGFGIATLNEDNYTWVLSRLAVELDEMPYQYEDFSIQTWVENVYRLFTDRNFAIIDKEG
                     KKIGYARSVWAMISMNTRKPADLLALHSGSIVDYVCDEPCPIEKPSRIKVASKEPVATL
                     VAKYSDIDINGHVNSIRYIEHILDLFPIEMYKEKRIRRFEMAYVAESYYGDELTLFMDD
                     AGEGVYDVEVKKNGSEVVCRSKVIFTEK"
     CDS             5296..6339
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: IlvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg58_5"
                     /sec_met_domain="IlvN (E-value: 3.4e-47, bitscore: 149.3,
                     seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="IlvC (E-value: 3.1e-41, bitscore: 130.3,
                     seeds: 295, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAQLNFGGVIENVMTREEFPLEKAREILKDETIAVIGYGVQGPGQ
                     ACNLRDNGFNVIVGQRPGKTYEKAVADGWVPGETLFGIEEACQKGTIIMCLLSDAAVMS
                     VWPTIKPYLTPGKALYFSHGFAITWNDRTGVVPPKDIDVIMVAPKGSGTSLRTMFLEGR
                     GLNSSYAVYQDATGKAFDKTIALGIGIGSGYLFETTFIREATSDLTGERGSLMGAIQGL
                     LLAQYEVLRENGHTPSEAFNETVEELTQSLMPLFAKNGMDWMYANCSTTAQRGALDWMT
                     PFHDAIKPVVQKLYASVKSGNEAQISIDSNSKPDYREKLNAELKALRESEMWQTAVTVR
                     KLRPENN"
     CDS             complement(6401..8314)
                     /locus_tag="ctg58_6"
                     /transl_table=11
                     /translation="MITFATMKEQDSNSPIIHLQQQQLLLRMEYEYEKEEFKRQTENMG
                     IARKVKRGLCWYPATPGRSYYNSLNQLVIEITHTENTDIEHNFEFGRPVCFFRQSADGK
                     ITYMNFTATVSYADETRMVAIMPGAGAVMEVQETDNLGVQLYFDETSYRTMFEALEDTL
                     RSKGNRLAELRDILLGTSKAGFRELYPVRFPWLNSTQETAVNKVLCARDVAIVHGPPGT
                     GKTTTLVEAIYETLHREPQVLVCAQSNTAVDWISEKLVDRGVNVLRIGNPTRVNDKMLS
                     FTYERRFENHPLYPELWSIRKNLRELGSRARRGSYDEREGVRSRMSRLRDRATALEIQI
                     NSELFDGAHVIASTLVSSNHRLLNGRRFGTLFIDEAAQALEAACWIAIRKADRVVLAGD
                     HCQLPPTIKCYEAARGGLERTLMEKVVSNKPAVVSLLKVQYRMHEEIMKFPSQWFYNGE
                     LEAASEVRYRGILDWDTPIHWIDTSEMDFKEEFVGETFGRINKAEADLLLSELKIYINR
                     ISGNRILEEKIDFGIISPYKAQVQYLRNKIKADASLKPYRSLFTVNTVDGFQGQERDVI
                     FISLVRANEEGQIGFLNDLRRMNVAITRARMKLVILGEAETLKHHGFYRKLLEFIQNIG
                     NQ"
     CDS             8429..10672
                     /locus_tag="ctg58_7"
                     /transl_table=11
                     /translation="MVYDLTMLKTFYAAYSEKIERVRNVLQRPMTLAEKILYAHLYDGD
                     KVKNYRRGEDYVNFRPDRVAMQDATAQMALLQFMNAGREQVAVPSTVHCDHLIQAYKGA
                     KEDIATATKTNEEVYNFLRDVSSRYGIGFWQPGAGIIHQVVLENYAFPGGMMVGTDSHT
                     PNAGGLGMVAIGVGGADAVDVMTGMEWELKMPRLIGVHLKGKLSGWVAPKDVILKLAGI
                     LTVKGGTNAIIEYFGPGTASLSATGKATICNMGAEVGATTSLFPYDERMGTYLKATGRE
                     EVAKMAASVAADLRADDEVLANPEKYYDRIIEIDLSLLEPYINGPFTPDAATPISKFAE
                     VVITNNYPRRMEVGLIGSCTNSSYQDLSRAASLARQVKEKNLKVASPLIVNPGSEQIRA
                     TAERDGMIAAFEDIGATIMANACGPCIGQWKRHTDDPERKNSIVTSFNRNFAKRADGNP
                     NTFAYVASPEITMALTIAGDLCFDPLRDTLVNAKGEVVKLSEPVGEELPAHGFIGGKEG
                     YIAPGKGQTEITVNPHSQRLQLLTPFPAWDGMDLLNMPLLIKVQGKCTTDHISMAGPWL
                     RFRGHLENISDNMLMGAVNAFNGETNKVWNRSTNTYGTVSGTAKLYKAEGIPSIVVAEE
                     NYGEGSSREHAAMEPRFLNVRVILAKSFARIHETNLKKQGMLALTFTDKADYDKIRERD
                     LISVMGLKDFASGRTLKVVLHHEDGSKESFEVQHTYNEQQIAWFRAGSALNAR"
     CDS             10676..11836
                     /locus_tag="ctg58_8"
                     /transl_table=11
                     /translation="MEKITVPFISGDGVGAEVTPSMQAVVNAAVRKSYGDRRGIEWKEV
                     LAGERAFHETGSWLPDETMEAFRTYKVGIKGPLTTPVGGGIRSLNVALRQTLDLYVCQR
                     PVRWYKGIVSPLKEPQKVDMCVFRENTEDIYAGIEWEAGTPEAEKFYRFLHDDMGVTKV
                     RFPETSSFGVKPVSREGTERLVRAACQYALEHHLPSVTLVHKGNIMKFTEGGFKKWGYE
                     LAECEFGKELAEGRLVIKDCIADAFLQNTLLIPEEYSVIATLNLNGDYVSDQLAAMVGG
                     IGIAPGANINYKTGHAIFEATHGTAPNIAGKDIVNPCSIILSAVMMLEYLGWKEAASLI
                     ENALEESFTEARATADLARFMPGGVSLSTSTFTREIVRRIENGNNE"
     CDS             11849..13192
                     /locus_tag="ctg58_9"
                     /transl_table=11
                     /translation="MKKEYLIYKLSEDLKEATRIENELFRKFDVKRGLRNEDGTGVLVG
                     LTKIGNVVGYERIPGGGLKPIPGKLFYRGYDVDDLAHAIIKEKRFGFEEIAYLLLSGRL
                     PDKEELSSFRELINDNMPLEQKTKMNIIELEGNNIMNILARSVLEMYRFDPDADDTSRD
                     NLMRQSIELISKFPTIIAYAYNMLRHATHGRSLHIRHPQENLSIAENFLYMLKKDYTEL
                     DARTLDLLLVLQAEHGGGNNSTFTVRVTSSTGTDTYSSIAAGIGSLKGPLHGGANIQVA
                     DMFHHLQENIQDWTNVDEIDTYFTRMLNKEAYNKTGLIYGIGHAVYTISDPRAILLKEL
                     ARDLAREKGKEREFAFLELLEERAIDVFGRVKNNGKTVSSNVDFYSGFVYEMIGLPQEI
                     FTPLFAMARIVGWCAHRNEELNFEGKRIIRPAYKNVLDEVAYVPIKKR"
ORIGIN
        1 tcttattttt ttctttaatt tgtttggaga ttataaaaaa gcccttacct ttgcagcacg
       61 tttgaaacaa aaaagaagaa ttaagttatg aatttacata catctattaa cctggcagtc
      121 ctgcatatta ttcgcgtcgt ggtggtggca tcaagagcgt gagaaaggtt atgtatgtat
      181 tcgtacgtta gaagataatt tattaagcct ttctcactat agtgggagag gctttttcat
      241 taaaaggaga tttgaaaatg aagcatcagt tacgcagctc gttcagcaca caaggtcgcc
      301 gcatggcggg agcccgtgca ttgtggacgg cgaatggtat gaagaaggaa cagatgggta
      361 agcccattat cgctatagtc aattcattta cacaattcgt ccccgggcat gtacatctgc
      421 acgaaatagg ccagtttgta aaggaagaga ttgaaaaact ggggtgtttt gctgcggagt
      481 tcaatacgat tgccattgac gacggtatcg ctatgggaca cgacggtatg ctttattccc
      541 tgccttcaag agatatcatt gccgatagtg tggagtatat ggtaaatgcc cataaggcgg
      601 atgctatggt ttgcatcagt aactgtgaca agattactcc ggggatgctg atggcggcta
      661 tgaggctgaa tataccgact gtgtttgttt caggcggtcc gatggaagcc ggggaatgga
      721 acggacaaca tttggatttg attgatgcca tgattaaatc tgctgatgaa agtgtgggcg
      781 ataaagaggt ggcacagatt gagcaacatg cctgccccac ttgcggatgc tgctcaggca
      841 tgtttaccgc taattccatg aattgcttga atgaagcgat tggattggca ctgcccggta
      901 acggcacgat tgtagccact cacgaaaatc gcaagaaact atttgaggat gcagccaggt
      961 tgattgtaga gaatgccttt agatattatg aagaagggga tgagagtgta ctcccgcgca
     1021 gtattgctac ccgcgaggca tttttgaatg ccatgacgct ggatattgcg atgggcggtt
     1081 ctactaatac agtacttcat ttgttggctg tggctcacga agccggagcg gattttaaga
     1141 tggatgacat tgacatgctc tcccgcaaga ccccctgctt atgcaaggtg gctcccaata
     1201 cccaaaagta tcatgtacaa gacgttaacc gtgccggtgg catcattgcc atcatggatg
     1261 agctagccaa gggcggattg gtcgatacga atgtccgccg tgtggatgga atgacgttgg
     1321 cagaggcaat cgaccggtat agtattacca gccctgatgt atgtaaagag gcaatcaaga
     1381 aatactccag tgcggcagcc ggaaagttca atctggtact tggctcacaa aatgcgtctt
     1441 atcaggaact cgatacggac cgtgcgaccg gttgtatccg tgatttggaa catgcataca
     1501 gcaaggatgg cggtctggcg gttttgaagg gaaatatagc tcaggacggt tgcgttgtca
     1561 agactgccgg tgtagacgag agtatctgga aatttacggg gccggcgaaa gtcttcgact
     1621 cacaagatgc ggcttgcgac ggtattctgg gtggaaaggt ggtcagtgga gacgtcgtcg
     1681 tcatcactca cgaagggccg aaaggtggac cgggtatgca agagatgctt tatcctactt
     1741 cttatatcaa atcccgccat ctgggtaagg agtgtgcatt gattaccgac gggcgtttca
     1801 gtggtggtac ttccggacta agtatcggac atgtttctcc cgaagcggct gccggtggta
     1861 atatcggcaa gattaaggat ggggacatta tcgaaattga tataccgaac cgttctatca
     1921 atgtgaagtt gacggatgaa gagcttgcag cacgccctat gactccggta acccgcaacc
     1981 gtgaagtctc caaagcattg aaagcatatg ccagtatggt gagttccgct gacaaagggg
     2041 ctgtgaggct gattgattaa aagcccccct ttccgaaagc gaggggagga gagaatgaaa
     2101 caaatttttc aagctactat tgagctttta aatataatga atagataaag tatggctgat
     2161 aataataaaa agagtaactt ttcctccctc tcccaaggag agggtcgggg tgaggctcta
     2221 ataacaggcg cagaagcatt gatgcgctct ctggagcatc agggagtaaa gactattttc
     2281 ggttatccgg gagggagcat catgccggta ttcgatgcct tatacgacca ccggaaggaa
     2341 ttgaaccaca tcttggttcg ccatgaacaa ggagcaaccc atgcggcaca aggctttgca
     2401 cgtgtatcag gcgaggttgg cgtttgtctg gttaccagtg gaccgggtgc taccaatact
     2461 atcacgggca ttgcagatgc catgattgac agtacgccta tcgttgtcat tgccggccag
     2521 gtagggacga acttcttggg tacggatgca tttcaggaag tggacttggt aggcattact
     2581 cagcctatca cgaaatggag ttaccagatt cgtcgtgcag aagatgtggc ctgggcagtg
     2641 gcacgtgctt tctatgtggc aaagagcgga cgtccgggac cggtcgtgct ggattttgct
     2701 aaaaacgccc aagtggagaa aacagaatat gcgcctacta aggtggacta tgtccgtagc
     2761 tatcttcccg ttcccgaaat ggagccggag gccatacggc aggctgctga attaataaat
     2821 ggtgcggaac ggcctttggt gctggtagga caaggcgtgg agctgggaga agcccagcaa
     2881 gagcttcgtg ctttcattga gaaagccgga atgcctgccg gatgcacttt attgggactt
     2941 tccgcattac ctacgaacca tccgttgaac aaaggaatgc ttggtatgca cggtaacctg
     3001 gggcccaata tcaataccaa taaatgtgat gtccttatcg ccgtaggcat gcgctttgat
     3061 gaccgtgtga cgggtaaatt ggaaacatat gccaagcagg cgaagattat ccactttgat
     3121 attgaccctg ccgaaataga taagaatgta aagaccgatg ttgctgtcct gggagattgc
     3181 aaagagacac tggctgccgt tacccaattg ctggaacccg ccaaccatca ggaatggatt
     3241 gacagtttcc ggcaatacga ggaagtggaa gaggaaaagg taatccgtcc ggaattacat
     3301 ccggcaggaa aagcgctaag catgggtgag gtggtgcgtg ctgtgagtga ggctacccat
     3361 aacgaggcga tattggtgac tgatgtcggc cagaatcaga tgatgtccgc ccgttatttc
     3421 aaatacagca aggaacgtag cattgttact tccggtggcc tgggtactat gggcttcggc
     3481 cttccggcag ctatcggtgc cacttttgga cgtccggacc gcacggtatg cgtattcatg
     3541 ggagacggcg gcttgcagat gaacctgcag gaactgggta ccatcatgga acaaaaggct
     3601 ccggtgaaga tgattctgtt gaacaataac ttcctgggca atgttcgtca atggcaggcg
     3661 atgttcttca atcgtcgtta ttcgtttact ccgatgatga atccggatta tatgaagatt
     3721 gcttcggcat atgatattcc tgcacgcagg gtaatgaccc gcgaggagct ggcaaaagcg
     3781 attgacgaga tgatagcgac tgacggacca ttcctgctcg aagcttgtgt ggaggaagaa
     3841 ggaaatgtaa tgccgatgac acctccgggc ggttcggtca atcagatgtt gttggaatgc
     3901 tgaagtcatg cgaaattaaa gaatttactc tatctatgga taaaaaacta tatacaatca
     3961 ttgttcattc ggaaaacttt gccggtttgc tgaatcaggt gacggctgtg tttacccgcc
     4021 ggcagataaa catcgagagt ttgaatgtat cggcctcctc catcaagggg gtacataaat
     4081 ataccattac cgcttggacg gataaggata ccattgaaaa ggtgaccaag cagattacca
     4141 agaaaataga tgtgctgcaa gcccattatt tcacggatga tgaaatctat cagcacgaga
     4201 ttgcccttta taaaataacg acccctacgc tggaagaaaa accggaggtg tccaaagtaa
     4261 tccgtaagta caatgcccgt attgtggagg tgaatgctgt atttgccatt gttgagaaga
     4321 atggcatgag tgaggaaata accaatcttt atgaggagtt gcgccagttg gattgcgtac
     4381 ttcagttcgt ccgttcgggt cgcgtagcca ttacgaccag ctgctttgag cgtgtcaatg
     4441 aatatctggc ggaccgtgaa gcaaaatatc gtcaaagtaa acaccaggaa ttatgatgag
     4501 cgaaaacaat aagataggta cctacaagtt tgttgccgaa ccgtttcatg tcgactttac
     4561 cggacggctg accatgggag tattgggcaa ccatttgttg aattgtgcgg gtttccatgc
     4621 cagcgaccgc ggttttggca tcgcgactct aaacgaggac aattatactt gggtattgtc
     4681 ccgtctggct gtcgaactgg atgaaatgcc ttatcagtac gaagatttct ccattcagac
     4741 ttgggtggag aatgtctatc gcctttttac agaccgtaat ttcgctatca tcgataaaga
     4801 gggcaagaag attgggtacg cacgttccgt ttgggcgatg attagcatga atacccgtaa
     4861 gccggcagat ttgctggctc ttcatagtgg cagcattgta gattatgttt gcgatgaacc
     4921 ttgcccgata gaaaaacctt cgcggataaa ggtggcctca aaggaaccgg ttgctacttt
     4981 ggtagccaaa tacagtgata ttgacattaa cgggcatgtg aacagcatcc gttacatcga
     5041 gcatatcctt gatttgttcc cgatagagat gtataaggag aagcgcatcc gtcgttttga
     5101 gatggcatat gtagccgaaa gctattatgg ggatgagttg actttgttca tggatgatgc
     5161 cggtgagggc gtttacgatg tggaggtgaa aaagaatggc agcgaagtgg tctgtcgctc
     5221 taaagtgata tttacagaga aataaataaa tttatcaacg ttggcgtaag ccacaaataa
     5281 aaattaaaac aaaaaatggc acaattgaat tttggcggtg ttattgagaa tgtaatgacc
     5341 cgcgaagaat ttcctttgga aaaagcacgt gagattttga aagatgaaac aattgcagta
     5401 atcggttatg gcgtacaagg cccgggccag gcttgcaact tgcgtgataa cggtttcaat
     5461 gtgattgtag gacaacgtcc gggcaagaca tacgaaaagg ctgtggctga cggatgggta
     5521 ccgggtgaga ctttgttcgg catcgaagag gcttgtcaga aaggtactat catcatgtgt
     5581 ctgttgtctg acgcagctgt aatgtctgta tggccgacta tcaaacctta tttgactccc
     5641 ggaaaggctc tttacttctc tcatggtttt gctattacct ggaacgaccg taccggcgtg
     5701 gttcctccta aagatattga tgttattatg gttgctccca aaggttccgg tacttcactt
     5761 cgtaccatgt tcctcgaggg tcgtggcttg aactcatcat atgccgtcta tcaggatgct
     5821 acgggtaagg cttttgacaa gacgattgca ctgggtatcg gcatcggttc gggatatttg
     5881 ttcgagacaa ctttcatccg tgaagccact tccgacttga ccggtgaacg cggttccttg
     5941 atgggtgcta tccagggatt actgttggct cagtatgagg tattgcgcga aaacggccat
     6001 actccttctg aagcattcaa tgaaacagtg gaagagttga ctcaatcttt gatgccattg
     6061 tttgccaaga atggtatgga ctggatgtat gccaactgtt ctactacggc acagcgtggt
     6121 gcgctggatt ggatgacccc gttccatgat gccatcaagc cggttgtaca gaaattgtat
     6181 gcaagtgtga agtcgggtaa cgaagctcag atttctatcg acagtaactc caaacccgat
     6241 tatcgtgaga agctgaatgc agaattgaaa gccttgcgtg aaagcgaaat gtggcagaca
     6301 gctgttacag ttcgtaaact tcgtccggaa aacaattaat cagctttata taaataggtg
     6361 aaataccctc ttcggtgtta ccggaggggg tatttcttta ttattgattc cctatatttt
     6421 gaataaactc caatagcttc cggtaaaaac cgtgatgttt cagcgtctct gcctctccca
     6481 atatcaccag cttcatacgt gcccgggtga tggctacatt cattctcctt aaatcattca
     6541 ggaatcctat ctgcccttct tcgttggcac ggacaaggct gatgaagata acatcgcgct
     6601 cttgcccttg gaagccatcc accgtattta cagtgaacaa gctgcgataa ggcttgagtg
     6661 aagcgtctgc ctttatcttg ttgcggagat attgcacttg tgccttgtaa ggggagatga
     6721 tgccgaagtc tattttttct tccagaatgc ggttgccact gatacggttg atgtagattt
     6781 tcagttctga taggagcagg tccgcttccg ccttattaat gcgcccgaaa gtctctccca
     6841 caaattcttc tttgaaatcc atttcggagg tgtcaatcca gtggatgggg gtatcccagt
     6901 ccaggatgcc ccggtaacgc acttcggaag cggcttccaa ctcgccatta taaaaccatt
     6961 gggaaggaaa tttcatgatt tcctcgtgca tgcggtattg tactttcagc aaagagacaa
     7021 cggcaggttt gttggacacc actttctcca tcaatgttcg ttccagacct ccacgggcgg
     7081 cttcgtagca ttttatggtg ggcggaagtt ggcagtggtc acccgccaat accacgcggt
     7141 ctgcttttcg gatagctatc cagcaggcag cctctaaggc ctgggctgct tcatcaatga
     7201 aaagggtgcc gaaacggcgt ccgttcagta gccggtgatt gctgcttacc agcgtggagg
     7261 ctatgacatg tgccccatca aaaagctctg aattgatttg tatttccaat gcggtggcgc
     7321 ggtcgcgcag gcggctcata cggctgcgta ctccttcgcg ttcgtcatag ctgccacggc
     7381 gggcacggct gcccagttca cggagatttt tccggatgct ccacagttcc ggataaagcg
     7441 gatggttctc gaaacgacgc tcgtaggtaa aggaaagcat cttgtcgttg acacgggtcg
     7501 gattgccgat acgcaggaca ttgacgccac ggtccacaag tttttccgaa atccagtcga
     7561 cggcagtatt gctttgggca cataccagta cctgcggttc ccgatgcagg gtttcataga
     7621 tggcttccac taaggtggtc gtttttccgg ttcccggagg accatgtaca atggccacgt
     7681 cgcgggcaca cagcactttg tttacagctg tctcctgcgt ggagttcagc cagggaaacc
     7741 gtacggggta gagctctcgg aaaccggctt tcgaggttcc cagcaatatg tcccgcaatt
     7801 cggccaggcg gttgcctttg gagcgtaacg tatcttccaa ggcttcgaac atggtccgat
     7861 aggatgtttc gtcgaaataa agttgcacgc cgaggttgtc cgtttcctgc acttccataa
     7921 cggcaccggc tccgggcatt atcgctacca tccgtgtctc gtcggcatag cttacggtag
     7981 cggtgaagtt catataggtt atttttccat cggcagactg gcggaaaaaa catacgggac
     8041 ggccgaactc aaaattatgt tctatatcgg tattttctgt gtgtgtaatt tctattacta
     8101 attgattcag tgaattatag taacttcgtc ccggagtggc aggataccag caaagtcccc
     8161 gtttcacttt ccgggcaatc cccatgtttt cggtttggcg tttgaattcc tctttttcgt
     8221 attcgtattc catgcgcagc aaaagttgtt gctgctggag gtgaataata ggactatttg
     8281 aatcttgttc cttcatggtt gcaaaggtaa tcattcttca cttccgacgg aaaaaatgct
     8341 ttattttgtt aaactattca gcctttttat ttgtttatga tattaatttg taatctttac
     8401 aataatgaaa aactaaaaaa tagtggttat ggtatatgat ttaacgatgc tcaaaacgtt
     8461 ttatgccgct tattcggaga agatagaacg cgtacggaat gtactacagc gtccgatgac
     8521 tttagcggag aaaattttgt atgctcattt gtatgatggg gataaagtga agaactacag
     8581 acggggagaa gactatgtga atttccgtcc cgaccgtgtg gccatgcagg atgcaacggc
     8641 ccaaatggcc ttattgcaat ttatgaatgc aggccgtgag caggttgccg tgccttccac
     8701 tgtgcactgt gaccatttga ttcaagcata taaaggtgca aaagaagata tcgcgactgc
     8761 tacgaagacc aacgaggagg tctataattt tctccgtgat gtttcttccc gctatggcat
     8821 aggtttttgg cagccgggag caggcattat tcaccaggtg gtattggaga actacgcatt
     8881 tccgggtgga atgatggtag gcacggactc tcatacgccc aatgccggag gtttgggcat
     8941 ggtggccatt ggtgtgggtg gtgccgatgc ggtggatgtg atgaccggca tggaatggga
     9001 attgaaaatg ccgcgtctga taggcgtaca cttgaagggt aaattgagtg gctgggtagc
     9061 tcccaaagat gttattctga agttggcggg tattcttact gtaaaagggg gaaccaatgc
     9121 catcattgaa tattttggac cgggaaccgc ttcattgtct gccactggaa aggctaccat
     9181 ctgcaatatg ggggcagagg tgggggcgac tacctccctt ttcccttacg atgagcgcat
     9241 gggtacttat ttgaaggcta ccggacgtga agaagtggca aaaatggctg cttccgtagc
     9301 tgccgacctt cgcgccgacg acgaagtgct ggcaaatccg gaaaaatatt acgaccgcat
     9361 cattgaaata gacctctcgc tgttggaacc gtatatcaat gggcccttta cgccggatgc
     9421 agcaacaccg atatcgaaat ttgccgaggt agtgataacc aataactatc cccgccggat
     9481 ggaagtcggc ctgatagggt cgtgtaccaa ttcgtcctat caggatttga gccgcgcagc
     9541 ctcccttgcc cggcaggtaa aggaaaagaa tttgaaggtt gcttctccgc tgattgtcaa
     9601 ccccggttcg gagcagatac gtgccactgc tgaacgcgac ggcatgattg ccgctttcga
     9661 agatattggc gcaacgataa tggcgaatgc ctgcggacct tgtattggcc agtggaagcg
     9721 ccatactgat gaccccgaac gaaaaaattc catcgtcacc tcttttaacc gtaattttgc
     9781 caaacgtgcc gatggaaatc ccaacacttt tgcttacgtc gcttccccgg agataacgat
     9841 ggcgctgacc attgccggtg acctttgttt cgacccgttg agggatacgc tggtcaatgc
     9901 caaaggagag gttgtgaaac tgtccgaacc ggtcggtgaa gaactgccgg cacacgggtt
     9961 tataggagga aaggaaggat acattgctcc aggcaaagga cagacggaaa ttacggtcaa
    10021 tcctcattca cagcgcttgc aactgctgac tcccttccct gcctgggatg gcatggactt
    10081 gctgaatatg cccttattga ttaaagtgca agggaaatgt accaccgacc acatctctat
    10141 ggcggggcca tggctccgtt tccggggaca tttggagaat atttcggaca atatgctgat
    10201 gggggctgtc aatgctttca atggagagac gaacaaggtt tggaaccgct ccaccaatac
    10261 ctatggaaca gtgtcaggca ctgcgaagct gtataaggcc gaaggtatcc cttccattgt
    10321 cgttgccgaa gagaattatg gtgaagggtc cagccgtgag catgctgcca tggaaccacg
    10381 cttcttgaat gtacgcgtca ttttggcgaa aagctttgcc cgtatccatg agacgaattt
    10441 aaagaaacaa ggcatgttgg cactgacctt tacggataag gccgattatg acaagattcg
    10501 ggaacgcgac ctgatttctg tcatggggtt gaaagatttt gcttcgggac gtacgttgaa
    10561 ggtggttctt catcacgagg acgggagtaa agaaagtttt gaagtacaac atacgtataa
    10621 cgaacagcag atagcctggt tccgggccgg ttctgcactt aatgcaagat agaatatgga
    10681 aaaaattact gtacctttta tttccggcga tggagtggga gcagaagtga ccccatccat
    10741 gcaggctgtc gtgaatgccg ctgtcaggaa atcctatggt gaccggcgtg gcattgaatg
    10801 gaaagaagtg ctggcaggag aacgtgcttt ccacgaaacc ggctcctggc tgccggatga
    10861 aacgatggaa gccttccgca cttataaggt gggcatcaaa ggtcctttga caacacctgt
    10921 cggcggaggt atccgttcgt tgaacgtggc attgcgtcag acgcttgatt tgtatgtctg
    10981 ccaacgtccg gtacgttggt ataagggtat tgtttctcca ctcaaagagc cgcagaaggt
    11041 ggatatgtgc gtattccgtg agaataccga ggatatttat gcaggcatcg aatgggaagc
    11101 cggaactccg gaggctgaaa agttctatcg ttttctccat gatgacatgg gggtgacaaa
    11161 agtccgtttt cccgaaacct cctcgtttgg cgtgaagccc gtttcaagag aaggaacaga
    11221 gcgcttggtg cgtgccgcct gccaatacgc gcttgagcat catctgcctt ccgtgacctt
    11281 ggtacacaaa ggaaacatca tgaaatttac ggaaggcggt ttcaagaagt gggggtacga
    11341 gctggcagaa tgtgagtttg gtaaagagct ggcagaaggg cgtctggtca tcaaggactg
    11401 cattgccgat gcattcttgc agaacacgtt gcttatcccc gaagaatatt ccgtgattgc
    11461 cacgttgaat ctgaacggtg attatgtgtc cgaccaactg gctgccatgg taggcggcat
    11521 cggcattgca ccgggtgcga atatcaacta taaaacgggg catgccattt ttgaggctac
    11581 tcacgggacg gctccgaaca ttgccgggaa agacattgtg aatccctgtt ccatcatcct
    11641 ttccgctgtg atgatgcttg aatatctggg ttggaaggaa gcagcctctc ttatagagaa
    11701 cgccttggag gaaagtttca cagaagcccg tgctactgcc gacttggcac gttttatgcc
    11761 gggtggcgtc tcgctgtcca cttcgacttt cacccgggag attgtaagga gaatagaaaa
    11821 tgggaataac gaataaaacg aaacgattat gaagaaggag tatctgattt acaagctttc
    11881 cgaagatttg aaggaagcta cccggattga gaatgaactg ttcaggaagt ttgatgtgaa
    11941 gcgcggtttg cgtaatgagg acggcacggg agtcttggtg gggttgacca aaataggcaa
    12001 tgtggtcggc tatgaacgca tccccggtgg agggctgaag cctattcccg gcaaattgtt
    12061 ctaccgcggt tatgatgtgg atgacttggc acacgccatc atcaaagaga agcgtttcgg
    12121 ttttgaggaa attgcctact tgttgctttc cggtcgcctg cccgacaagg aagaactctc
    12181 ttctttccgt gaactcatca acgacaacat gccgctggag cagaagacca agatgaatat
    12241 cattgaactc gaaggaaaca acattatgaa catcctggcg cgcagcgtgc tcgagatgta
    12301 tcgttttgac cctgatgcag atgacacttc ccgcgataat ctgatgcggc agagcattga
    12361 gcttatttcg aaattcccga ccatcattgc gtatgcctat aacatgcttc gccatgccac
    12421 ccatggccgt tcactgcata tccgccatcc gcaggaaaac ctttccattg ccgagaattt
    12481 cctctatatg ctgaagaagg actacacgga gctggatgcc cgcacgctcg acctgctgct
    12541 ggttcttcag gccgagcacg gtggtggtaa caactccact tttaccgtac gtgtcacttc
    12601 ttctaccggg acggatactt actcttcgat agcggcaggt atcggttcct tgaaagggcc
    12661 gcttcatgga ggtgccaata tccaggttgc cgatatgttc caccatctgc aggaaaacat
    12721 tcaggactgg acgaatgtgg atgagattga tacttacttc acccgcatgc tcaacaagga
    12781 agcctataac aagaccggct tgatatatgg tatcggacat gccgtctata ccatttccga
    12841 cccgcgcgcc attctgctga aagagcttgc ccgcgacctt gcccgcgaaa aagggaaaga
    12901 acgcgagttc gctttccttg aactgctcga ggagcgcgcc attgatgtgt ttggccgtgt
    12961 gaagaataat ggcaagacgg tttcgagtaa tgtggatttc tattcgggct ttgtctacga
    13021 gatgattggg ctgccgcagg aaatcttcac gcctttgttt gccatggcac gtattgtcgg
    13081 ttggtgtgca catcgcaatg aagaattgaa tttcgaaggc aagcgtatta tccgtcctgc
    13141 ctataagaat gttttggatg aggtggctta tgtgcccatt aagaaacggt aaggattaga
    13201 cttgtatctt ttaaatcgtt ccatcacggg gaaaaaatcg ttccaccatg gtggaacgat
    13261 tttttctcca tggt
//
