GCA_947569925.1 - 11 region(s)

Identified primary metabolite regions

c00002_gnlPro.. (original name was: gnl|Prokka|HCAEOLLB_2)

Region	Type	Class	From	To	Most similar known cluster		Similarity
Region 2.1	porA	SCFA	150,819	173,661	porA C. sporogenes	POR	60%

c00005_gnlPro.. (original name was: gnl|Prokka|HCAEOLLB_5)

Region	Type	Class	From	To	Most similar known cluster		Similarity
Region 5.1	TPP_AA_metabolism	Putative	8,182	34,275

c00006_gnlPro.. (original name was: gnl|Prokka|HCAEOLLB_6)

Region	Type	Class	From	To	Most similar known cluster		Similarity
Region 6.1	Pyruvate2acetate-formate	SCFA	75,060	97,206	Pyruvate to acetate-formate B. thetaiotaomicron	PFL_acetate	100%
Region 6.2	TPP_fatty_acids,Pyruvate2acetate-formate	SCFA	115,185	157,049	Pyruvate to acetate-formate B. thetaiotaomicron	PFL_acetate	100%
Region 6.3	TPP_fatty_acids	Putative	178,815	203,671

c00008_gnlPro.. (original name was: gnl|Prokka|HCAEOLLB_8)

Region	Type	Class	From	To	Most similar known cluster		Similarity
Region 8.1	NADH_dehydrogenase_I	E-MGC	61,208	91,273	NADH dehydrogenase I Bacteroides sp.	NADHD	66%

c00013_gnlPro.. (original name was: gnl|Prokka|HCAEOLLB_13)

Region	Type	Class	From	To	Most similar known cluster		Similarity
Region 13.1	fatty_acids-unassigned	Putative	62,131	92,866

c00018_gnlPro.. (original name was: gnl|Prokka|HCAEOLLB_18)

Region	Type	Class	From	To	Most similar known cluster		Similarity
Region 18.1	Fumarate2succinate	SCFA	29,121	52,634	Fumarate to succinate B. thetaiotaomicron	SUC	100%

c00022_gnlPro.. (original name was: gnl|Prokka|HCAEOLLB_22)

Region	Type	Class	From	To	Most similar known cluster		Similarity
Region 22.1	PFOR_II_pathway	SCFA	68,453	86,405	PFOR II pathway B. thetaiotaomicron	PFORII	100%

c00026_gnlPro.. (original name was: gnl|Prokka|HCAEOLLB_26)

Region	Type	Class	From	To	Most similar known cluster		Similarity
Region 26.1	succinate2propionate	SCFA	36,478	61,034	Succinate to propionate B. theta	PRO	75%

c00033_gnlPro.. (original name was: gnl|Prokka|HCAEOLLB_33)

Region	Type	Class	From	To	Most similar known cluster		Similarity
Region 33.1	Rnf_complex	E-MGC	34,690	59,907	Rnf complex C. sporogenes	RNF	83%

Compact view

c00002_gnlPro.. - Region 1 - porA

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Location: 150,819 - 173,661 nt. (total: 22,843 nt) Show pHMM detection rules used

porA: (Fer4_7 and TPP_enzyme_C and POR and POR_N and PFOR_II and not (EKR or Fer4_16))

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c00005_gnlPro.. - Region 1 - TPP_AA_metabolism

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Location: 8,182 - 34,275 nt. (total: 26,094 nt) Show pHMM detection rules used

TPP_AA_metabolism: (TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or PFOR_II))

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resistance genes

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c00006_gnlPro.. - Region 1 - Pyruvate2acetate-formate

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Location: 75,060 - 97,206 nt. (total: 22,147 nt) Show pHMM detection rules used

Pyruvate2acetate-formate: ((PFL_acetate1 or PFL_acetate2) and Radical_SAM)

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c00006_gnlPro.. - Region 2 - Pyruvate2acetate-formate,TPP_fatty_acids

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Location: 115,185 - 157,049 nt. (total: 41,865 nt) Show pHMM detection rules used

TPP_fatty_acids: (TPP_enzyme_C and (minimum(2, [ACD1_car, ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase, CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3, Carboxyl_trans, CoA_trans, CoA_trans_230_acto, CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1, ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C, Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or PFL_proline or PFL_toluene) and not (POR or POR_N))
Pyruvate2acetate-formate: ((PFL_acetate1 or PFL_acetate2) and Radical_SAM)

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c00006_gnlPro.. - Region 3 - TPP_fatty_acids

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Location: 178,815 - 203,671 nt. (total: 24,857 nt) Show pHMM detection rules used

TPP_fatty_acids: (TPP_enzyme_C and (minimum(2, [ACD1_car, ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase, CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3, Carboxyl_trans, CoA_trans, CoA_trans_230_acto, CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1, ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C, Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or PFL_proline or PFL_toluene) and not (POR or POR_N))

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c00008_gnlPro.. - Region 1 - NADH_dehydrogenase_I

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Location: 61,208 - 91,273 nt. (total: 30,066 nt) Show pHMM detection rules used

NADH_dehydrogenase_I: (Oxidored_q4 and Oxidored_q6 and Complex1_30kDa and Complex1_49kDa and NADHdh and Oxidored_q3 and Oxidored_q2 and minimum(4, [Fe-2S_thioredx, Fer2_4, Fer4_7, Molybdop_Fe4S4, Molydop_binding, NADH-G_4Fe-4S_3, NADH_4Fe-4S, Proton_antipo_M, Proton_antipo_N, SLBB]))

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c00013_gnlPro.. - Region 1 - fatty_acids-unassigned

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Location: 62,131 - 92,866 nt. (total: 30,736 nt) Show pHMM detection rules used

fatty_acids-unassigned: (not (EC1_2-faecali or baiH or baiCD or ECH1_Enoyl_CoA_DH1 or ECH1_Enoyl_CoA_DH2 or ECH1_Enoyl_CoA_DH3 or ECH1_Enoyl_CoA_DH4 or POR or POR_N or PFOR_II) and minimum(4, [AcetylCoA_hyd_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, EC1_2-faecali, ECH1_8_CARC, ECH_1, ECH_2, HBT, HCDH, HCDH_N, Thiolase_C, Thiolase_N, ketoacyl-synt]))

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c00018_gnlPro.. - Region 1 - Fumarate2succinate

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Location: 29,121 - 52,634 nt. (total: 23,514 nt) Show pHMM detection rules used

Fumarate2succinate: (Succ_DH_flav_C and FAD_binding_2 and (Fer2_3 or Fer4_7 or SucD_FumR))

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c00022_gnlPro.. - Region 1 - PFOR_II_pathway

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Location: 68,453 - 86,405 nt. (total: 17,953 nt) Show pHMM detection rules used

Region on contig edge.

PFOR_II_pathway: cds(POR and POR_N and PFOR_II and EKR and Fer4_16 and TPP_enzyme_C)

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c00026_gnlPro.. - Region 1 - succinate2propionate

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Location: 36,478 - 61,034 nt. (total: 24,557 nt) Show pHMM detection rules used

succinate2propionate: (minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not Cytidylate_kin)

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c00033_gnlPro.. - Region 1 - Rnf_complex

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Location: 34,690 - 59,907 nt. (total: 25,218 nt) Show pHMM detection rules used

Rnf_complex: (Complex1_51K and minimum(5, [FMN_bind, FeS, Fer4, Fer4_9, NQR2_RnfD_RnfE, Rnf-Nqr, RnfC_N, SLBB]))

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