LOCUS       c00062_gnlPro..        14332 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|OCHJEBBA_62.
ACCESSION   c00062_gnlPro..
VERSION     c00062_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-05 02:38:37
            Original ID  :: gnl|Prokka|OCHJEBBA_62
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14332
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14332
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[264:4332]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /neighbourhood="10000"
                     /product="TPP_fatty_acids"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      265..4332
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /neighbourhood="10000"
                     /product="TPP_fatty_acids"
                     /protocluster_number="1"
     cand_cluster    1..14332
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /kind="single"
                     /product="TPP_fatty_acids"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14332
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_fatty_acids"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /tool="gutsmash"
     CDS             complement(2..76)
                     /locus_tag="ctg62_1"
                     /transl_table=11
                     /translation="MLITIIILVLSAVFFVNGKIRSDLV"
     CDS             265..672
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: HBT"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg62_2"
                     /sec_met_domain="HBT (E-value: 9.1e-15, bitscore: 45.2,
                     seeds: 132, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMEEITCKPDYSNSMAEHLGIRFLPPTENAVHAEMPVDHRTSQPF
                     GMLNGGASLALAEIVAGHGSMSLCREGEYACGVQVSGNHLSAVPVGGKVFATGKLIHRG
                     RSSHIWNIDITSPQGQLVSTVRVVNFILKKK"
     CDS             669..1811
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Chorismate_bind"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg62_3"
                     /sec_met_domain="Chorismate_bind (E-value: 2.6e-57,
                     bitscore: 184.5, seeds: 119, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNLPDIHTQNLLDCLTHSRLGFALYRLPWTDECYLVLQTSGDVEQ
                     LADIQELNEKKGFVMAPFRISEEHPLVLIRPDVTAYDWNEISEALSSLECVDTLLTCKS
                     RQNELSPFVSEETDKEQYTRAFGRFITPLQEKQFQKLVLSRSSARHIGDDFSPLGAFVR
                     ACNNYPRMMIYLCHTPASGTWLGSTPEILLSGQGKEWHTVALAGTMPMQDEVMPTNWDK
                     KNQEEQGYVADYIRRIAKKFGNKMTEKGPYTARAGQLVHLKTDFYFLLKNTDHIGDLLQ
                     ELHPTPAVCGLPKEEAFRFILNNEGYDRSYYSGFTGWLDTEGHTDIYVNLRCMEIKPGE
                     AILYAGGGILASSEVESEWVETGDKMNTMRSILHPDFISK"
     CDS             1838..3511
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg62_4"
                     /sec_met_domain="TPP_enzyme_C (E-value: 2e-07, bitscore:
                     21.2, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYSDKKNILQLVALLKAHGVRKIVLCPGSRNAAIVHTLANIEDFT
                     CYSVTDERSAGFFAIGLSLQGGGPAAVCCTSGSALLNLHPAVAEAFYQQVPLIVISADR
                     PAAWIGQMDGQTLPQPHVFGTLVKMSVNLPEVHTEEDEWFCNRLINEAILETTHHGKGP
                     VHINVPISEPIYRFTAKTLPEARVITRYQGLSVYDRDYKELIERLNKYNKRMVVVGQMN
                     LIYLFEKKYVKPLYKHFAWLTEHLGNQTIPGIPIKNFDAAVYSMTPERQEDMAPEILIT
                     YGGHIVSKQLKKYLRNHPPREHWHVAADGKIADLYGCLTTVIEMDPFEFLEKIAFLLDN
                     KPTHYPLMWENYCKTIPMPDLAYSEISVIGKLIRALPEPCALHLANSSTVRYAQLFTVP
                     PRVEICCNRGVNGIEGSLSTAIGYAAASSKLNFIIIGDLSFFYDMNALWNQNYGANIRI
                     LLLNNEGGEIFHTLPGMDKSSRSREFITAEHYTTAKGWAEERGFIYMKVTGEEELEEAM
                     QPFTSPETRMQPMLLEVFTDKEKDTTLLREYYHGLKNKNE"
     CDS             3511..4332
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: ECH_1"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg62_5"
                     /sec_met_domain="ECH_1 (E-value: 1.1e-85, bitscore: 277.1,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="METRKWKTIKEYQDILFDFYNGIAKITINRPRYRNAFTPTTTSEI
                     SDALYYCRECQDINVVVLTGAGDKAFCSGGDMHVKGHGGYIGTDGVPRLNVLDVQKQIR
                     SLPKPVIAMVNGYAIGGGHVLHVVCDLTIASENAIFGQTGPKVGSFDAGFGSSYLARIV
                     GQKKAREIWFLCRQYSAQEALEMGLVNTVVPFDRLEDETVAWAEKMMEHSPLALRMIKA
                     GLNAELDGQAGIQELAGDATMLYYMTEEAQEGGKAFLEKRKPRFQDYPKFP"
     CDS             4353..4736
                     /locus_tag="ctg62_6"
                     /transl_table=11
                     /translation="MDIEEFRKYCLSLGDVSEKMPFGKFAARYDSILAFYVYGHMFCFI
                     DIDNFTFVNVKSTSDEIEYIKERHVSVGNPINQSLKHWLQLNFDGDIPDTSIYTWVQRA
                     FEIVRDKYTKPTTHKKKCSKPKL"
     CDS             4715..5770
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MR_MLE_C"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg62_7"
                     /sec_met_domain="MR_MLE_C (E-value: 1.4e-29, bitscore:
                     93.4, seeds: 401, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFQTQIIKKQLHFKQPAGTSRGVYTTRDVWYILLTDTGSRHYGVG
                     ECAPLPALSCDDIPSYDEVLATACKNLEKNGEIDREALLPYPSILFGMETALLHFRARS
                     LQFWHTPFSKGKEGIPINGLIWMGNFDEMYRRIGEKMQQGFRCIKLKIGAIDFEKELEL
                     LAHIRRHFTPAQIELRVDANGAFSPTDALEKLHRLSEFQLHSIEQPIRAGQWDEMARLC
                     AATPFPIALDEELIGINRRNRKIELLETIRPQYIILKPSLHGGISGSEEWMELAAERGI
                     GSWVTSALESNIGLNAIAQWCATLQPALPQGLGTGLLFTDNIDYPLHIEGDCLWFHPEE
                     QEPDLLNWLKQ"
     CDS             5767..6852
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1025:AMP-binding enzyme (Score: 56.8; E-value: 5e-18)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg62_8"
                     /sec_met_domain="AMP-binding (E-value: 1.5e-18, bitscore:
                     56.8, seeds: 145, tool: rule-based-clusters)"
                     /sec_met_domain="AMP-binding_C (E-value: 1.9e-08, bitscore:
                     25.5, seeds: 272, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTKFCTNRNKQTILIESIPYSNWEIEMVRMNIPADNRSFRQELFS
                     FLSEWFDPADTLLVHTSGSTGKPKELHVEKEHMMESACLTCSFLGLQKEDSALLCMPLQ
                     YIAGKMVVVRALVAGLDLLPVTPSGHPLKDLTKAPVFAAMIPMQVYNSLQVPEERAILQ
                     QIRHLIIGGGPIDSQLNAALKDFPHAVWSTYGMTETLSHIALRRLNGPEASDWYTPFES
                     IQIRLSKENTLVIYAPEICGKELVTNDIAEINGQNQFRILGRKDNTINTGGVKVQIEQV
                     EAALKEHLSVPFLITSAPDEKFGEIIVLLAEGQLPDDIEQTCTHQLPPYWRPKRFVPVF
                     KLPLTETGKPDRAIAKLLAQK"
     CDS             7108..7995
                     /locus_tag="ctg62_9"
                     /transl_table=11
                     /translation="MLYNTPKPQDTKEGLSDQDFSIYMDAHTVPFSKYPSYLPEGVLGM
                     CTEGNAEIQIGLRKYVICANDILIFMPGFLVSFIKSSLTFTIDYCTFSNALFYDVINGS
                     IKRFPTGFHTYTQTHCIYSLSQEKAEQFSLYFRLLYNRATSPTYLFTKESITNLLKLPF
                     LELYADYYSTVKEHKVTTLHKEEIGYFFLDLLLKHYKENKEVAFYAEKLHVSSKYLTEA
                     LTLVSGKSPKEWIIHYTLQEIYALLENPSISIQEIVQRTRFANLATLRRFFKRHTGTSL
                     LQYRKQDLYKNNQQ"
     CDS             complement(8058..8234)
                     /locus_tag="ctg62_10"
                     /transl_table=11
                     /translation="MELPDDPMMLFSMVNMKLRDCYHSLDELCDDMNVDKELLVKKLKA
                     AGFEYSKENNKFW"
     CDS             complement(8341..10629)
                     /locus_tag="ctg62_11"
                     /transl_table=11
                     /translation="MLRDYQIEMKTRLMEAWKAHRSVMVQMPTGTGKTHLLASVVSEFV
                     SSAGSGVWLIAHRRELVAQMEETLAKYGIRREDTPVRVMSVQWLSRHWNEAGDAPGLIV
                     IDEAHHALAASYTEMWKRYPAAKKLGVTATPCRLNRRGFTELFEVLVTSWSIAEFIEKG
                     VLSVFDYVSIRPGSEEQRLIDGLEKRGADGDYQVKEMDAVLNRRPGIERLYRSVRQFAS
                     GKKGMVYAISIEHARRIAEYYSRRGVNAVAVDSKTPAMERKRMVEEFRHGKIEVLVNVD
                     VFSEGFDCPDVEFVQLARPTLSLAKYLQQVGRGLRRSEGKEACMLIDNVGLYRIFGLPT
                     QRWNWDAMFRGRMAGKGSLPGRMNCDASVTAFPVVERPAEAGGDLVMVMEHGRLLSSIR
                     EQALPDEKEQSPSCRLRAFVDKETGLWGLEKGDEMLPDVSFKEILSIKGRFAVGRLRNG
                     CVRVLDDTGALVAELGHCCEVRLLKDDLLQVRHAGNSVSYVDLRNGRCYAVRPRVLRYG
                     SIELLQVNRTYYSRTRQVYTNTCGLPSSSIVWMGFYVKMYDGRVPSRCRRMEDGGFCCE
                     PQVCLLEGDEERAYYLSGRLPDQSIVVMDEEGRYYHVEKGHGKRYVACNRPSDRSEDFD
                     EAVALLRRQADERVEKHLQEEKCETERKRQRIISRSVEAVPFQIGVKWGLRTAEQILIP
                     PVYRRILRPVGGYCAYQDSSCQWGGADCRRKDHYPGPVYGGGDRQGWNGASYFGSGEDG
                     NGEADGLIG"
     CDS             complement(10685..11134)
                     /locus_tag="ctg62_12"
                     /transl_table=11
                     /translation="MMINIYGGNNLIAPVASSAIQNFYGDRGDEAADQPEDSEKTENTE
                     SVADEKPAQEPAELSDDEFYVSVYIPDIKVMRAYKILLGECTTARELAVVVGKMLADEN
                     CRNVDKHTVVKAAFIKSLLPFAKRLVSGGTIANIRAQINNMLASK"
     CDS             11338..11907
                     /locus_tag="ctg62_13"
                     /transl_table=11
                     /translation="MKEYIMSFFNAPVTNKIPTCICSVAGLHTYISTNPQLEELTHKVR
                     AGLGDKQVFRKNKQTLLPYVTPAGIFSYCKEQCMQVPSGLFVIDIDELASTEEAAMWRD
                     RLFADEVLHPVLSFVSPGNQGVKLFIPYRINPFLSVEESFDNALHTAWEYLEWKYELKV
                     DRANADLSRACFLSHDGEAKINNHKY"
     CDS             11911..13854
                     /locus_tag="ctg62_14"
                     /transl_table=11
                     /translation="MNDSISILEQLVTAIEQAGVNVAPTYQEYMPLAFAIANTCGEEGR
                     TRFHRICRISEKYHHDEADKLYGHALTKGTGRNSLGTVFHLAEVAGVKMDPKLANLQNL
                     QSLHTHTRARVSYNAHPDASDGTPPDAVFTDPASPLSDGVPKAILPARLPSFPDYRWPA
                     FLQGIIDCGNSPAQRDILLLGAATVLGSTLNKLVSFVYGRKHKYPCLQVFVTAPPASGK
                     GALTWVRRLAEPIHNALLDTYREKIKTYRMEKTKWDTLGKEKVNTPEPEQPQLKMLLIA
                     GDNTGTGIQENLMDSGGVGLICETEADTVSTAIGGDHGHWSDLLRKCFDHDRLAYNRRT
                     NHEYRECNVTFLCVLLSGTPAQIKPLIPSAENGLFSRQLFYYMPAIEEWEDQFNEADTD
                     YDSRFLEWGAQWKEVLNAITASVSNINMKLTHEQKEIFNFHFARVFGRASAIHGNQMKS
                     AVTRIAINIFRIISIIALLRSLESLLPGGERSGEPQENIVRTLLNCPGLTPSAHIPQEN
                     IADGIVPQFNLSIRTDDFYAVLALVEPLYRHACHILSLLPAGTPTAPSANMTPETLFDC
                     LPLRFTRNEAIDKGEQVGVPAGSVDSLLKRMTERGQLVKVGRGEYEFNARMHTRTCVGV
                     RESASFASLQDS"
     CDS             13872..14096
                     /locus_tag="ctg62_15"
                     /transl_table=11
                     /translation="MKDFLYFPSMTKGSLALLYFPGSNPRIATRHLMRWINGCPPLMEE
                     LSATGYYTSQKVFTSRQVTLINRHLGSPG"
ORIGIN
        1 ccacaagatc cgaccgtatc ttgccattta caaaaaatac tgcggacagt acaaggataa
       61 taatcgtaat gagcataggt attaaattat tgttttattc attcgttgtt gcatttgtac
      121 gaattctttt tgcaaaataa aaaatatatt ccgaaaatag aaacaaaccc cgaatgtttt
      181 tgttcttaaa agaacaacat tagcgacatt ttcatctaaa atttatgtat ttttgtagcc
      241 ctatagaaaa gaacagacat acaaatgatg gaagaaataa cctgcaaacc tgattattcg
      301 aattcgatgg cggaacatct gggtatccgg tttctccccc ccaccgagaa tgcggtacat
      361 gccgaaatgc ctgtagacca tcgtacttca caaccctttg gtatgttgaa cggcggcgcg
      421 tcactggctc tggccgagat tgtggcagga catggctcca tgtcgctatg ccgggaaggc
      481 gaatatgcct gcggagtaca agtaagtgga aatcatctgt cggccgtacc cgtcggaggc
      541 aaagtattcg ccaccggcaa actgattcac cgcggcagat cctcgcatat atggaatata
      601 gatatcacca gcccacaggg acaactggtt tctactgttc gtgtcgttaa tttcatactg
      661 aaaaagaaat gaatctacca gatatacata cgcaaaattt attagattgc ctgacacaca
      721 gccgcctcgg tttcgccctc taccggttac cttggacaga cgaatgctac ctggtattgc
      781 aaacctcagg cgatgtggaa caattagcgg atattcagga actgaatgaa aaaaagggat
      841 ttgtcatggc tcctttccgg atatcggagg aacatccctt ggtacttatc cgtccggatg
      901 tcacggcata cgactggaac gaaatcagcg aagcactgtc ttcactggaa tgtgtggata
      961 ccctgctcac ctgcaaaagc cggcagaatg aactctctcc ttttgtttcc gaagaaacgg
     1021 ataaagaaca atatacccgc gcattcgggc gtttcatcac tcccttacaa gagaagcagt
     1081 ttcaaaaatt ggttctgtca cgttcttccg ccagacatat cggagatgat ttttcaccac
     1141 ttggcgcttt tgtccgggcc tgtaacaatt atccgcgcat gatgatttac ctatgccaca
     1201 cccccgcttc cggaacctgg ctgggcagca caccggaaat cttattaagc ggacaaggca
     1261 aagaatggca caccgtggcc ctggctggta caatgccgat gcaggacgaa gtgatgccga
     1321 caaactggga caagaagaac caagaagaac agggctatgt ggctgattat atccgccgga
     1381 tcgccaaaaa attcggcaac aagatgacgg agaaaggtcc ctataccgcc cgtgccggac
     1441 aattggtaca cctcaagact gatttttatt tcttgttgaa aaatacagac catataggcg
     1501 atttattgca agaactccat cccactcccg ccgtctgcgg cctgcccaaa gaggaggctt
     1561 tccggtttat tctgaacaac gaagggtacg accgcagtta ttattccgga ttcaccggat
     1621 ggctggacac agaggggcat accgatatct acgtcaatct gcgctgcatg gaaataaagc
     1681 cgggtgaagc catcctgtat gcaggaggag gaatactggc ttcctcggaa gtagaatcgg
     1741 aatgggtgga aacgggagac aagatgaata cgatgcgaag catccttcat cctgacttta
     1801 taagtaaata aatggaaaca attaaagtag aagaataatg tattcagaca aaaagaacat
     1861 acttcagttg gtggcacttc tcaaagcgca cggtgtgcgg aaaatagtgc tttgtcccgg
     1921 cagccgtaat gctgccatcg tacacactct ggccaatata gaggacttca cttgttattc
     1981 tgtaaccgat gaacgcagtg ccggtttttt tgctatcggc ctatctttac aagggggagg
     2041 tcctgccgca gtatgctgca cctccggttc ggccctgctg aacctgcacc ctgccgtagc
     2101 cgaagctttt taccaacaag tacctctgat tgtcatttct gccgaccgcc ccgccgcctg
     2161 gataggacaa atggacggac aaaccctgcc ccagccccat gtgttcggaa cgttagtcaa
     2221 gatgtctgtc aacctgcccg aagtacatac agaggaagac gaatggtttt gcaaccgcct
     2281 catcaacgaa gccatactgg aaaccaccca ccacggcaaa ggacccgtac atatcaatgt
     2341 acccatttcc gaacccatct accgcttcac cgccaaaaca cttcccgagg cacgtgtcat
     2401 cacccgttat cagggactga gcgtgtacga ccgtgactat aaggaactga tcgaacggct
     2461 gaacaagtac aacaagcgca tggtcgtggt aggccagatg aatctgattt acctgttcga
     2521 aaaaaaatat gtgaaaccgc tttataaaca tttcgcctgg ttgacggaac atctgggcaa
     2581 ccagaccatc cccggcattc ctatcaagaa tttcgacgcc gccgtttatt ccatgacgcc
     2641 ggagcgccag gaagacatgg cccccgaaat actgattacc tacggcggac acatcgtatc
     2701 taaacaactt aagaaatacc tgcgcaacca tcccccgcgc gaacactggc atgttgccgc
     2761 tgacggaaag atagccgatt tatacggttg cctgaccact gtcatcgaga tggatccgtt
     2821 tgagttcttg gaaaaaatag ctttcctgct ggacaacaaa ccgacccatt atccgctgat
     2881 gtgggaaaac tattgcaaaa ccattccgat gccggacctt gcctattccg aaatctccgt
     2941 tatcggaaaa ctcatccggg cattgcccga accctgtgcc ctgcatctgg caaacagctc
     3001 caccgtgcgc tatgcacagt tatttacagt tcctccccgg gtggaaatct gttgcaaccg
     3061 gggcgtgaac ggcatagaag gctccctgtc caccgccatc ggttatgccg ccgcttccag
     3121 caagctgaat ttcatcatca taggcgactt gagcttcttc tatgacatga acgctctgtg
     3181 gaatcaaaat tacggtgcca acatccgcat cctgttactg aataacgaag gaggagaaat
     3241 attccatacc ctgcctggaa tggacaaatc aagccgttcc cgggagttta tcacagccga
     3301 gcattacacc accgccaaag gctgggcgga agaacgtggc tttatttaca tgaaagtgac
     3361 cggagaagaa gagctggaag aagcgatgca gccattcacc tcacccgaga caaggatgca
     3421 acccatgctg ctggaggtgt ttaccgacaa ggaaaaagac accaccctat taagagaata
     3481 ttatcacgga cttaaaaata aaaatgaata atggaaacaa gaaaatggaa aaccatcaaa
     3541 gaatatcaag atattctgtt tgacttttac aacggaatag cgaaaatcac catcaaccgt
     3601 ccgcgttacc gcaacgcgtt cacccccacc actacttcgg aaatcagcga cgccctgtat
     3661 tactgccgcg agtgccagga tatcaatgta gtggttctga ccggagcagg tgacaaagcc
     3721 ttctgcagcg ggggagatat gcacgtaaaa ggtcatggcg gttatatcgg cacagatgga
     3781 gttccccgtc tgaatgtgct ggacgtacaa aagcaaatcc ggtcactgcc aaaaccggtc
     3841 atcgccatgg taaacggtta cgccatcggc ggcggccatg tgctgcatgt ggtatgcgat
     3901 ctgaccattg cctcagaaaa tgccattttc ggacagacag gtcccaaggt aggcagcttc
     3961 gacgccggat tcggctcttc ctatctggca cgcatcgtag ggcagaagaa agcccgtgaa
     4021 atatggttcc tttgccgtca atactccgca caggaagcac tggaaatggg attagtcaat
     4081 acagtcgttc ctttcgaccg cctggaagac gaaaccgtgg catgggcaga aaagatgatg
     4141 gagcacagcc cgctcgctct tcgtatgatc aaagccggac tgaatgccga actggacgga
     4201 caagccggca tacaagaact tgccggagat gccaccatgc tgtattacat gacagaggaa
     4261 gcgcaggaag gagggaaggc atttttggaa aaacgcaagc cacggttcca ggattatccg
     4321 aagttcccat aaacaaacta caaattcaaa gcatggacat tgaagaattc agaaaatatt
     4381 gtctttcgtt aggtgacgtt tccgaaaaga tgccatttgg caaatttgct gcaagatatg
     4441 attccatcct tgccttttat gtttatggac acatgttctg ttttatagac attgacaatt
     4501 tcacttttgt caatgtcaaa tctacttcgg acgaaattga gtatataaaa gagagacatg
     4561 tttcagtcgg caatcccatc aaccaaagtc tgaaacattg gcttcaactt aattttgatg
     4621 gtgatattcc cgacacgagc atatacacat gggtccaacg cgcctttgag attgtcaggg
     4681 ataaatatac caaaccaact acacataaaa aaaaatgttc caaacccaaa ttataaaaaa
     4741 acaattacac ttcaagcaac ctgccggtac ttccagagga gtatatacta cccgggatgt
     4801 atggtacatc ctcctcaccg acaccggcag ccgccactat ggcgtgggtg aatgcgcccc
     4861 tctccctgcc ctgagctgtg atgatatccc ctcatacgac gaggtgttgg ccactgcctg
     4921 caagaacctg gaaaagaacg gggaaataga ccgggaagcc ttgcttccct atccgtccat
     4981 cctgttcggt atggaaaccg ccctgctgca tttccgggca cgcagcctgc aattctggca
     5041 caccccgttc agcaaaggca aagagggtat ccccatcaac ggactcatct ggatgggaaa
     5101 ctttgacgag atgtaccggc gcatcgggga aaagatgcag caaggtttcc gctgcatcaa
     5161 actcaaaata ggcgctatcg actttgaaaa ggaactggag ctgctggcgc acatccgccg
     5221 gcatttcacc ccagcccaaa tcgaactgcg tgtagatgcc aacggtgctt tctctcctac
     5281 cgatgccctc gaaaagttac atcgtctttc cgaattccag ctccattcca tcgaacagcc
     5341 catccgtgcg ggacaatggg atgaaatggc ccgactctgt gccgccaccc cctttcccat
     5401 tgcactggat gaagagctga taggcatcaa ccggcgcaac cggaaaatag aattgctgga
     5461 aaccatccgt cctcagtaca ttatcctgaa accttctctg cacggaggaa tcagcggctc
     5521 cgaagaatgg atggaactgg cggctgaaag aggcatcggt tcatgggtca cttccgctct
     5581 ggagtccaat atcggactga atgccatcgc acaatggtgt gccaccttac agcccgccct
     5641 tccccaagga ctaggtaccg gtttgctgtt taccgacaat atagactatc cgcttcacat
     5701 cgaaggggac tgcctttggt tccaccccga agaacaagaa cccgacttac taaactggtt
     5761 gaaacaatga caaaattctg caccaataga aacaaacaaa ccattctgat agaaagtatc
     5821 ccctactcca attgggaaat tgaaatggta agaatgaata tccctgccga caaccgaagt
     5881 ttccggcagg aacttttctc ctttctttcc gaatggtttg acccggcaga caccctgctg
     5941 gtacatacct caggctccac cggcaaaccc aaggaactgc atgtagaaaa agaacacatg
     6001 atggaaagcg cctgcctcac ctgttccttc ctcggactac aaaaagaaga ttccgccctg
     6061 ctctgtatgc ccttgcaata cattgccgga aaaatggtgg tagtacgtgc cttggtagcg
     6121 ggactggact tgctgcctgt cactccatcc gggcatcctt taaaagacct gacaaaagcc
     6181 cccgtctttg ccgccatgat ccccatgcaa gtctataact cactgcaagt tcccgaagag
     6241 agagcgatat tgcaacaaat caggcacctc attatcggag gtggtcctat cgactcccaa
     6301 ttgaacgctg cgttaaaaga tttcccccat gccgtatggt ctacttacgg catgaccgaa
     6361 accttatcac acattgccct acgcagactg aacggtcctg aagcttcaga ctggtacacc
     6421 cctttcgaga gcatacagat ccgtctgagt aaagaaaaca ccttggtgat atacgctccc
     6481 gaaatttgcg gaaaagaact ggtgaccaat gacatagccg agataaacgg acagaaccaa
     6541 ttccgcattc taggcagaaa agacaatacg atcaataccg gaggagtgaa agtgcagata
     6601 gaacaagtag aggccgcatt gaaagaacac ctgtccgttc ctttcttgat cacctccgct
     6661 cccgacgaaa aattcggaga aatcattgtg ctgcttgccg aagggcaact gcccgacgac
     6721 atagaacaga cctgcacaca tcaattacct ccctactggc gtcccaaacg ttttgttccg
     6781 gtattcaaac ttcccctgac agaaaccggg aaacccgacc gtgccatagc caaattactg
     6841 gcgcaaaaat aactccgctc cattcataaa gggtgaattc aaaaacaaat caaacgatct
     6901 ttttgaattc acccttcttt ctgtaaaaaa gaataatttt ccgtgttctc ctacaactta
     6961 cgggaagcta aaattgttct cctatcatta tattaaaaaa atcaaataca cgtagttttt
     7021 ttccgtttta ttttccctta tgtccactac ttccggcgga atgtatcatt aaattctaat
     7081 tttgtgaacc tagagctgat acaaagtatg ttatataata ccccaaaacc acaggatacc
     7141 aaagaaggac tgtccgatca agatttcagt atttatatgg atgcgcacac agtgcctttc
     7201 agcaaatacc cctcttatct gccggaagga gttttgggta tgtgtactga agggaatgcc
     7261 gagatccaga ttggtctccg gaaatatgtt atttgtgcaa acgacattct tattttcatg
     7321 ccgggattct tggtttcatt tataaaatcc agtctgactt tcaccatcga ttattgtact
     7381 ttttcaaatg ccctttttta tgacgtgatc aatggaagta tcaaacgttt tccgaccggt
     7441 tttcatacct acacccaaac ccactgcatc tattcgctat cccaagagaa agcggaacag
     7501 ttctccctct atttccggtt actatacaac agagctactt ctccaactta tttatttaca
     7561 aaagaatcta ttaccaatct gctgaaatta ccttttctgg aactttatgc agactattac
     7621 agcacagtaa aagaacataa agtcaccacc ttgcataaag aagaaatcgg atactttttt
     7681 ctggatttgc tgttaaagca ttacaaagaa aacaaagaag tggcgttcta tgccgaaaag
     7741 ttgcatgttt cctccaaata cctgactgaa gccttgactc tggtaagtgg aaaatccccc
     7801 aaagaatgga ttatacatta taccctgcaa gagatttacg cattattgga gaatccatcc
     7861 atcagcatac aggaaatcgt tcaaagaacc cggtttgcca atcttgccac cttaagacgt
     7921 ttcttcaagc ggcataccgg aacatccctg ttgcaatacc ggaaacagga cttatacaaa
     7981 aataatcaac aataggtatc tcaataaaaa aatcagcccg tcccaagcat tcttccggaa
     8041 cgggctgatc cctctatcta ccaaaacttg ttgttttcct tactatactc aaatccggcc
     8101 gccttcaatt ttttcaccaa cagctccttg tctacattca tatcatcaca aagctcgtcc
     8161 agcgaatgat agcagtcacg aagtttcata ttcaccatgc tgaaaagcat catcgggtca
     8221 tcaggtaatt ccatatcaat atctcctttt ttaaaatcgg atgcaaagtt acaaaacttt
     8281 tcataatgat ccgtattcca tcgctaaata tcggtctgac aaaaagttat cccctgcttt
     8341 ttatcctatt aatccgtcag cttcaccgtt tccatcttcc ccggaaccaa agtaagacgc
     8401 gccgttccat ccctgtctat ctccacctcc atataccggg cccggataat gatccttccg
     8461 tctacagtca gcaccccccc actggcagga gctgtcctga taggcgcaat aaccacccac
     8521 cggacgcaat attctccgat agacaggtgg aatcaaaatc tgctccgctg tcctcaaccc
     8581 ccatttcact cctatctgaa aaggtacggc ctccacactc ctgctgatta tacgctgccg
     8641 tttccgttca gtctcgcact tttcctcctg caaatgtttc tccacacgct cgtccgcctg
     8701 ccttcggagc aatgccaccg cctcatcaaa atcctcactc cggtccgacg gacggttaca
     8761 agccacataa cgctttccat gtcctttctc cacatgataa taccgtccct cctcatccat
     8821 caccacaata ctttgatccg gcaaccgtcc gctcagataa taagcacgct cctcatcccc
     8881 ttccaacaga caaacctgcg gttcacaaca aaagcctcca tcttccatgc ggcggcatcg
     8941 ggaaggcact ctgccatcgt acatcttcac ataaaacccc atccacacaa tggacgaaga
     9001 aggcaacccg catgtattgg tatacacctg ccttgtcctg ctgtaataag tacggttcac
     9061 ctgtaacaat tctatgctcc cgtatctgag gacacgcggg cggacagcat aacaccggcc
     9121 gttccgtaaa tccacataag acaccgaatt cccggcatga cggacttgca acaaatcatc
     9181 tttcagcaac ctcacctcac agcaatgccc cagttcggcc accaaagccc ccgtatcatc
     9241 cagtacccgg acacacccgt tccgaagcct ccctacggca aaacgtcctt tgatactcaa
     9301 aatctcttta aacgaaacgt ccggcagcat ctcatctccc ttttccaatc cccaaagacc
     9361 tgtttcctta tctacaaatg ccctcaacct gcatgacggt gactgctcct tctcatccgg
     9421 caaagcctgc tctctgatgg aagaaagcaa acgcccgtgc tccataacca tcaccaagtc
     9481 cccaccggct tcagccggcc tttccaccac cggaaaagcg gtaacggaag catcacaatt
     9541 catccgtccg ggcaaactcc cctttcccgc catccgtccc cggaacatag catcccagtt
     9601 ccatcgctgt gtaggaagcc cgaaaatgcg gtacagcccc acattgtcta tcagcataca
     9661 cgcctccttg ccctccgatc tccgcaatcc gcgtcctacc tgctgcaaat atttagccag
     9721 tgacaaagta ggacgggcca gttgtacaaa ctccacatcg ggacagtcga acccctcgct
     9781 aaatacatcc acattcacca gcacctcgat ttttccatgt ctgaactcct ccaccatccg
     9841 cttgcgttcc atagcaggag tcttgctgtc cacagccacc gcattcactc cccgcctgct
     9901 gtaatactcc gctatccgcc gggcatgttc aatgctgatg gcatacacca tccccttctt
     9961 gccggaagca aactgcctga cactgcggta caggcgctcg ataccgggac gcctgttcag
    10021 taccgcatcc atctctttca cctgataatc cccatcggcc ccccgtttct ccagaccatc
    10081 aatgagccgc tgctcctcgc tgccgggacg gatggataca taatcgaaca cagacaacac
    10141 gcctttttca ataaactcgg caatactcca cgaagtaacc agcacctcga acagttccgt
    10201 gaacccccta cggttcaggc ggcaaggtgt ggcagtcaca cccagtttct ttgcggcagg
    10261 ataacgcttc cacatctccg tgtaagaagc ggctaaggca tgatgagcct cgtctatcac
    10321 aatcagtccc ggagcatcac ccgcctcatt ccagtgccgg gatagccatt ggacagacat
    10381 taccctgacc ggagtatcct ccctccggat accatattta gccagcgttt cctccatttg
    10441 cgccaccagt tccctacgat gggcaataag ccatacccca ctgcctgcag aagacacaaa
    10501 ctcactgacc acagatgcca gcagatgtgt cttgcccgta ccggtaggca tctgcaccat
    10561 cacactccgg tgagctttcc acgcttccat cagacgtgtt ttcatctcta tctgataatc
    10621 ccgcaacata aataatttgc cgatttgcta acgtgccaat ggagtaagag gataatcgaa
    10681 aaaattattt actagccagc atattattaa tctgcgcccg tatattggct atcgtaccgc
    10741 ccgacacgag tcgtttggca aaaggtagca acgacttgat gaaagccgct ttcaccaccg
    10801 tgtgtttgtc tacattccta cagttctcat cggccagcat ctttcctacc accaccgcca
    10861 gttcgcgtgc cgtggtacac tctcccaaaa gtatcttgta agccctcatc acctttatat
    10921 cgggtatata gaccgatacg taaaattcat catccgacag ttccgccggt tcctgtgccg
    10981 gcttctcatc cgccacactt tctgtattct ccgttttctc agaatcttcc ggttggtcgg
    11041 cggcctcatc accccggtcg ccataaaagt tctgaatggc ggaagatgcc acaggagcaa
    11101 tcagattatt tccgccataa atatttatca tcatatcagg tttttcattc atatactatt
    11161 tcttttctct attctttaat tattatcaac agatcgttaa tcaaaatcca tatttcatca
    11221 atatataatc aatagcatgc actaatagta aacagatagt aaacggttat gaatcgattt
    11281 ccatacgtca ttccctaccc gtatatttgt gcagataaat caaaatcaat ttcttttatg
    11341 aaagaataca tcatgtcatt tttcaatgca cccgtcacca ataaaatacc cacatgtata
    11401 tgcagtgtgg cagggcttca tacctacatc agcaccaatc cgcaactgga agaactgacg
    11461 cataaagtca gagccggact cggagacaag caagtgttcc gaaagaataa acagaccctt
    11521 ttaccgtatg tcactccggc aggtatcttc tcttactgca aagagcaatg catgcaagtt
    11581 ccttcgggcc tctttgtcat agatattgac gaactggctt ccaccgaaga agcggcaatg
    11641 tggcgcgacc gtctctttgc cgatgaagtg ctgcaccccg tactttcctt tgtcagcccc
    11701 ggaaatcagg gagtaaaact ttttatccct tatcgcataa accctttcct gagcgtagaa
    11761 gaatccttcg acaatgccct gcacaccgca tgggagtatc tggaatggaa atacgagctg
    11821 aaagtggaca gggccaatgc cgacttgtcc agagcctgtt ttctgtcgca cgacggagaa
    11881 gcgaaaatca ataaccataa atattaaaaa atgaacgatt ctatttctat cttggaacag
    11941 ctggtaacag ccatcgaaca agcgggagtc aatgtggccc ccacctatca ggaatatatg
    12001 ccgctggcct ttgccatagc caacacttgc ggcgaggaag gacgcacccg gttccaccgc
    12061 atctgccgca tatccgaaaa gtaccaccac gatgaagcag acaaactgta cggacatgct
    12121 ctgaccaaag gaacaggcag aaattccctg ggaaccgtct tccatctggc agaggtggcc
    12181 ggggtgaaaa tggacccgaa acttgcaaac ttgcagaact tgcagtctct ccacacccac
    12241 acacgtgcac gcgtatcgta taatgcccat ccggatgcct ccgacgggac tccgcccgat
    12301 gccgttttca cggacccagc ctcccccctg tccgacggcg tgcccaaagc catcctccct
    12361 gcccgacttc cctctttccc cgactaccgc tggcccgcct tcctgcaagg gatcatagac
    12421 tgcggtaact ctcccgccca acgggatatc ctgctgctgg gtgcagcaac cgtgctggga
    12481 agcaccctca acaaactggt aagttttgtg tacggacgaa aacacaagta tccctgtctg
    12541 caagtgttcg tcaccgcgcc tcccgcttcc ggcaagggtg cactgacctg ggtacgccgt
    12601 ctggcagaac ccatacacaa cgcgctgctg gacacctacc gggaaaaaat aaagacctac
    12661 cgcatggaaa agacaaaatg ggacactttg gggaaggaaa aggtaaatac ccctgaaccc
    12721 gaacagcccc agctgaaaat gctcctcata gccggtgaca ataccggtac aggcatacag
    12781 gaaaacctga tggactccgg aggcgtagga ctgatatgcg aaaccgaggc cgacaccgtg
    12841 agcaccgcca ttggaggcga tcacggacac tggagcgacc tcctccggaa atgtttcgac
    12901 catgaccggc tggcctacaa ccggcgcacc aatcacgaat accgcgaatg taacgtcacg
    12961 ttcctctgcg tgcttctcag cggcacgcct gcacaaatca agccccttat cccatcggcc
    13021 gaaaacggat tgttctcgcg ccagctgttc tactatatgc ctgccattga agaatgggaa
    13081 gaccagttca acgaagcgga tacagactat gactcccgtt ttctggaatg gggggcacaa
    13141 tggaaagaag tgctgaacgc catcaccgcc tcggtgagca acatcaacat gaagctcacc
    13201 cacgagcaaa aagagatatt caacttccac tttgcccgtg tattcggacg agcctccgcc
    13261 attcacggta accagatgaa aagcgctgta acccgtattg ccatcaatat cttccgcatc
    13321 ataagcatta tcgccctgct gcgctctctg gaatccctgc tgccgggagg cgaaaggagc
    13381 ggcgaaccac aggaaaacat cgtgcgtacc ctgctgaact gtcccggact gaccccgtcg
    13441 gcccatattc cacaagaaaa catagcagac ggaatcgtgc cgcaattcaa cctctccatc
    13501 cgcaccgacg acttttatgc cgtgctggcc ttggtggaac ctctgtaccg ccatgcatgc
    13561 cacattctct cgctcctgcc cgcaggaacc cccaccgcac catcggcgaa catgactccc
    13621 gaaaccctgt tcgactgcct tcccctgcgc ttcacccgca acgaagccat cgacaaagga
    13681 gaacaggtag gagttccggc aggctcggtg gactcgctgc tgaaacgtat gaccgaacgc
    13741 ggacagctgg tcaaagtggg gcgtggcgaa tacgaattca acgcgcgcat gcacacacgt
    13801 acgtgtgtgg gtgtgagaga gagtgcaagt tttgcaagtt tgcaagattc ctgaatttaa
    13861 aatgtataaa tatgaaagat ttcctttatt tcccatccat gacaaagggt agcctagctc
    13921 tgctctattt tcccggttca aatccccgga tagccacccg gcatctgatg aggtggataa
    13981 acggctgtcc ccctctgatg gaagagttat ccgcaacggg ttactatacc tcgcaaaaag
    14041 tcttcacgag ccgccaggtg acactgatca accggcatct gggcagcccc ggatagccct
    14101 gcaagctctt tggaacagga tgaaagccat aaagtgccac aaggtgtcat aaagcgtcag
    14161 cacgcatttc acagtaccta tctttgcaat gtcaacaatg agggagccga tacgttacta
    14221 accttcggcc tagcatgtta ctaacatgta accccatacg ttactaacct tcagccttac
    14281 acgttaccta cgtgcaatcc gcaagaaaag taaagtattc tccttcttca ct
//
