LOCUS       gnlProkkaGGKPGPDI_16   13356 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|GGKPGPDI_16.
ACCESSION   gnlProkkaGGKPGPDI_16
VERSION     gnlProkkaGGKPGPDI_16
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 23:35:50
            Original ID  :: gnl|Prokka|GGKPGPDI_16
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 68963
            Orig. end    :: 82319
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13356
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[5000:8356]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..8356
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..13356
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..13356
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             1283..1639
                     /locus_tag="ctg16_68"
                     /transl_table=11
                     /translation="MVNKSENSVIFFYEDGSRGRDVLTRFIGEAGLKSGMSDGYNAYVF
                     IDDELKAAETGTRLGKTTHQVYLAHARAKFMKASEQAGDRNADIFIKYIGLLYDLERQY
                     DRDGIPPERRGKLR"
     CDS             2200..3405
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010:NAD-dependent epimerase/dehydratase (Score:
                     104.7; E-value: 1.1e-31)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg16_69"
                     /sec_met_domain="RmlD_sub_bind (E-value: 3.5e-11, bitscore:
                     35.1, seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKSSKIYVAGHRGLVGSAIWNNLMQRGYTNLVGRTHRELDLTDQ
                     CAVKKFFDEEQPDAVVLAAAFVGGIMANSLYRADFIMMNMKIQCTVISEAYVHGVKKLL
                     FLGSTCIYPKNASQPMKEGCLLTNELEYTNEEYAIAKIAGLKMCESYNLQYGTNYIAVM
                     PTNLYGPNDNFHLENSHVMPAMMRKVYLAKLINDGNWEAIRKDLSIRPVGANIKENDEK
                     VRYIIDGNSSEAEILKVLAFYGIENNKVSLWGTGLPLREFLWSEDMADASVHILLNVNF
                     SDIIGVEKYSSVHYGNKADGAVDRNHSIGRGGAIPNLGEIRNCHINIGTGKELAIRELS
                     ELVVKSVGFTGIVEFDTTKPDGTMRKLIDVSKLHSLGWTHKVEIEEGVQRLFYWYTESL
                     KT"
     CDS             3439..4536
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010:NAD-dependent epimerase/dehydratase (Score:
                     254.8; E-value: 2.1e-77)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg16_70"
                     /sec_met_domain="RmlD_sub_bind (E-value: 3.2e-12, bitscore:
                     38.5, seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSQNIALITGVTGQDGSYLSEFLLAKGYEVHGIIRRSSVDFRERI
                     AHLEGTPSFHLHYADLTDSMSLVKLVGMVQPTEIYNLAAQSHVQVSFDAPEFTADVDAI
                     GVLRVLEAVRTNHLEKTCKIYQASTSELYGKVEEVPQNENTPFHPYSPYAVAKLYGFWI
                     VKEYREAYNMFCCSGILFNHESERRGENFVTRKITLAAARIAQGKQDCLYLGNLDSLRD
                     WGYAKDYVECMWLILQHETPEDFVIATGVQHTVREFATLAFHYVGIELCWDGEGVNEKG
                     IDTATGKVVIAVSEDFYRPTDVVNLWGDPTKAKKELGWNPMTTTFEELVKIMVDYDMKK
                     IAADQAAFEIRKMNLAEYLEKGIVK"
     CDS             complement(4659..4901)
                     /locus_tag="ctg16_71"
                     /transl_table=11
                     /translation="MNYIQMPRMNDISTHPNINFFTHILFIILTFRFLYLLVRTQSFLH
                     ICKYSFSPIKKQNILHLFKSQSKVTTYDYITYFYI"
     CDS             5001..6134
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 205.4;
                     E-value: 1.8e-62)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg16_72"
                     /sec_met_domain="phosphonates (E-value: 2.3e-121, bitscore:
                     396.7, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 6.4e-64, bitscore:
                     208.1, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVVGSLKGVDEVIPQETLDYVPNLEKMRPDYVVHGDDWKEGVQKQ
                     TRQRVIDTIAAWGGKVVDIPYTKGISSTQLNCKLKEIGTTPEVRQKRLKRLIAAKSIVR
                     IMESHCGLTGLIIENTSVDVNGIKREFDGMWSSSLTDSTSKGKPDIEAVDLTTRLHDLN
                     DTLECTTKPIIFDGDTGGKIEHFVFTVRTLERLGISAIIIEDKIGLKKNSLFGTDAVQT
                     QDSIEGFCAKIKAGKHAQVADDFMIIARIESLIAGKPVADAIERAYAYVEAGADGIMIH
                     SKHKSGDDIKEFCQIFRKRYASIPIIVVPTTYNHITEEELSSWGVNVVIYANHMLRSAY
                     PAMVNTAKSILLHSRSYEANDMCMPVKEILELIPGTK"
     CDS             6144..7274
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 68.1;
                     E-value: 1.1e-20)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg16_73"
                     /sec_met_domain="TPP_enzyme_N (E-value: 5.3e-17, bitscore:
                     54.4, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 6.8e-21, bitscore:
                     67.1, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MISPRFFVDSLAAMQIDFYTGVPDSLLKNICAYITDCLPKESNVI
                     AANEGGAIGLAAGYYLATAKIPVVYMQNSGEGNAVNPLMSLTDREVYNIPILLLIGWRG
                     EPGVKDEPQHVKQGKVTLELLETMGIRYEVLSMNETECLNQLKKAKAYMEETSEPFALV
                     IKKGSFSDHLLQKKKDEGEEFVRETAIKIVASYMESDAVAVSTTGMISRELFEYRESVY
                     QSHQCDFLTVGSMGHASQIALGIALQKKNRKVYCFDGDGALLMHLGSIAIIASMHLDNY
                     VHVVFNNGAHDSVGGQPTVALEIDLPQIALACGYALVLSVADEGTLHEALEKIKGAHGP
                     VFLEIRVKKGARKDLGRPTTTPIQNKEALMRFLLEE"
     CDS             7490..8356
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Fe-ADH"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg16_74"
                     /sec_met_domain="Fe-ADH (E-value: 3.6e-63, bitscore: 205.9,
                     seeds: 218, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEKGLELLHTTNANVVVAIGGGSVLDMAKLIRFFYSYSGNPIGRN
                     FKKERELLPLIALPTTAGTGSEATHFAVLYKDRIKYSVEHDDILPDYAIIYSPFTYSND
                     KYLTACSGFDALAQAIEAYWNVNACEESDEYAEKAIYLLWQNLPLAVNAPTKDIRDKVS
                     EGAYWAGKAINITKTTAPHAFSYPFTTYYGYPHGHAVALVFPYIAALNLNIEAMNISKL
                     YSLLGINDSEMVEDIFLEFLSNIGLQKRECDIFDNKLILDNVNLSRLKNNPVVINKEMA
                     INLINRI"
     CDS             8378..9538
                     /locus_tag="ctg16_75"
                     /transl_table=11
                     /translation="MKVLVIFIDMVRTDLMFLYNNKAKATPFDLLIEQIGGTLFTNCYT
                     PAPDTPRSLACMQTGLLPTMNGCDSRIKWPQFYIDKSIDTMWDLLIRNNIEINYFNQKS
                     SYETGPISRKDKTKIKVYHLLDDFKKNILSGSTEDELDYLTLNDYHWCIDDYGGTINAT
                     IKAKCILAEILKEYFVQHDINEYDHIFIHSDHGHLLDKEIAIQKSDLEYLNDSRTKILM
                     FHHQKNDQKGRVSYNRNLHSVQDVFATMMEVFHIDTDKRNSCSLLSTQGHDFIVIEDHN
                     NFAVTLNQRILLWRYISKGGGSLYTNIYNTSILGDVDRESAVKCIKKYSPSYIDCEKQI
                     EILNKYKQLKSEQICYNNGTKRPGYGWRFATKVKNRIKRRMLKWFY"
     CDS             9526..10800
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg16_76"
                     /sec_met_domain="Polysacc_synt (E-value: 7.5e-15, bitscore:
                     47.5, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVLLNRWKNKIVEVGLVIMSTLIELITSLIIVKLAAMYLVKADYG
                     FYSLILSIFTLFSLLPFTSLHTGISRYIIDVKNKGYLSQLYIHFWGIHLSFFIIYSLLC
                     LFAYNFLSSAWKELMFFLFLFCCTKIYKQFLFCILNTRRKRGSVVLGRIIDLVIEVSLI
                     LLFVCDILTIKKLLFSSIIGSLCVILFFVYIEKSDLVVSNIRMTRFKYLLKEILSFSTP
                     LIIWGIFGWLQSMVARWFIDSYLSKEDVANFSALFSMALLPATALLSIVSNFFTPISYE
                     HEYRMKGTIRMYVHRVLIWGTLIWGMLLLFVYLLGDWMIVLFLDEKYLNVLPYLPYVMI
                     GTGIYAMGQIAVIEMYYYKLQYKLLFPTILPGCLTFIGCYLFIQDFGIKGAILNNAVTY
                     AIYGILYIIYAFYYSKKLRLNNYCI"
     CDS             10797..11756
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg16_77"
                     /sec_met_domain="Glycos_transf_2 (E-value: 1.3e-34,
                     bitscore: 111.9, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNERLISIVVPIYNAEKYFARCLKSLFEQDYLNIEYVFINDCTPD
                     NSMNILNDILEEYPMRQKKTNIIHNKKNKGIAETRNIGVAVATGDYILFVDSDDYIDTN
                     MVSRLCEVAIENDTDIVLCNQILIESVKGNDVLNISYTDKREYLNKVLHGQFPCCIWGK
                     LIKKALFVKHSVAAMPGVNHGEDLQVMIPLYYYAHNINVADTTYFYNKFNASSYTNTLK
                     TEGIVSMIKSYKMVADFLSIHNSFTSVADLQESTLIHKVSLLSVASAQDYSLVAKIYRD
                     IPIWTVNIGISYKILLMLVDWGWYNVAYGVVKLYLKIR"
     CDS             11761..12636
                     /locus_tag="ctg16_78"
                     /transl_table=11
                     /translation="MIIAKLFGGLGNQMFIYATAKALALKSGQDYSFDVVTGFKDDYKF
                     KRDLLLSYFPAALIEAPHKLSFQYFGGRLFRKISRFLGFCIPVFNIRFICEQRPYIYHC
                     EYFDMAKKGELYIEGYFQSYRYFHSIRKELLKDFSFSEDLKLSVSDEAKLICDDEFVPV
                     AMGVRRYQEMKGEFGELTIVPASFYEHAVNCIKKKIINPKLFIFSEDMNWVQSNLQFDI
                     PVYYVKPKSGKLSALQDMYLMSICNHHIISNSTFYWWGAYLSNKENNIVIVPNNFLNRD
                     CTLEEWIVIE"
ORIGIN
        1 ttgattgatg aatacgataa gcctttgctt cagactcttt cggataaaca gttgacggaa
       61 gaatatcgcc ggatattgaa agctttttat ggagtgctga aaagtgccga ccgttatttc
      121 cgttttgttt ttttgacggg tgtgacgaag tttgcgcaga ttagcgtgtt cagtgacttg
      181 aatcagttgc aggatatcag tacatggccc gattattcct ctttatgtgg tattaccaag
      241 gaagagttgg tcaagacatt tactccggag atagaacgtt tgggcatctc caatggtatg
      301 gactttgata caattctgga acagatgacc aagttatatg acggttatca tttttaccct
      361 cattgcgaag gggtctttaa tcctttcagt gtattgaatg catgcaagtc gaggattttg
      421 gataattttt ggtttcagac cggcactcct acctatctgg taaacttatt gaaagagagt
      481 gattatgatt tgcgccttct gatagagggg ggtgaagtga cggcttccgc tttttttgag
      541 tatcgtgcag aagtaaagaa tccgcttccc atgatttacc agagtggcta tctgaccatc
      601 aaggattacg acagggatgt tttattgtac actttggggt ttcccaatga tgaagtacgc
      661 tatggtttct tgaattttct ggtacgttct ttgccggtat accgtacgat ttaagtgata
      721 ataccgaacg tcattatcaa gctgtttttt atgtagtttt cactttgatg ggacaatttg
      781 ttgaaacgga aatccgcagt gcccgtggtc gtgccgatgc tgtggtgaaa acaaaagata
      841 ccatttatgt tttgagttta aactgaatgg aagtgccgag gaggcgttgc ggcagattga
      901 tgaaaaaggg tatcttattc cttttgcact ggacggaaaa cgtttggtga aggtaggggt
      961 gaatttcagc agggaaaaaa ggaatgtaga gagatatttg gtggaataaa agatttctta
     1021 gttgtcgatt gggctttact tggttattct tgacaaaccg tctggacact tataatatga
     1081 ttgggattca aggtcgggca aaagagtata aatcagactt gtcgaaagtc cccagtcgta
     1141 ttcttgaaag aaagatgatt ccggtgtttc atttggatgt aaaccttgtt gaggaacgtt
     1201 tcgggacggt ctattatgtg gaggcaggca agaaactcgt aaactgtgac atgaccatta
     1261 taagaaatgt tatatccggg tattggtcaa caagtctgag aattctgtta tcttctttta
     1321 tgaggacggt tcccgtggac gtgatgtgct gactcgtttc atcggtgagg ccgggttgaa
     1381 aagcggaatg tcggatggct ataatgccta tgtatttata gatgacgagc tgaaggcggc
     1441 agagactggc acaaggctgg gcaaaaccac ccatcaagtg tatctagccc atgcgagggc
     1501 aaagtttatg aaagcaagtg agcaggccgg agaccgtaac gcggacatat ttataaaata
     1561 tatagggctg ctgtacgatt tggagcggca atatgacagg gacggcattc caccggaaag
     1621 acggggaaaa ctcaggtagg gtctggaaac caaagatatt ctgataaatc tccggcagca
     1681 tcttggattt gaaaaaggaa aggagctgtc ctggagaatt cgttgaccac acagcgcaac
     1741 tctatgctcc acttcggcag tgacgaagtg gaggagatgg cggttgccta acatagcatc
     1801 atcagtacgg tgaagatgca gtgacgttcg gcatgggagt atctcggtaa gttttttact
     1861 aaaatcttta atggttacag gaattttttc agtctgctac ctgataagat aggattggca
     1921 atatgccaat agttaataaa tacgttgaat tttaacaact cactatatag gcacccgcaa
     1981 aagtgcctat ataaaggggt atgctccaat ttgagtacaa acgattctaa atctactgag
     2041 aatcgaaaat ctgaactgat tccgaaaaat tccgattcca tccgaaatat tcaattctca
     2101 gaggctttaa caatagtagt tctgcaatac cctcatattc taataaatta tagtgaaggt
     2161 atggcagagg attaaaaagg ctataaccag agatttttta tggataaatc aagtaaaata
     2221 tatgttgcag gtcatcgtgg acttgtaggc tctgctatct ggaataacct aatgcagaga
     2281 ggttacacta atctcgtagg tcgtactcat agggagctgg acctcaccga tcagtgtgct
     2341 gtcaagaaat tttttgatga agagcagccc gatgcagtcg tgcttgcagc cgcctttgtt
     2401 ggtggtatca tggccaattc gctctatcgc gctgatttta taatgatgaa catgaagatt
     2461 cagtgcactg tcatttcaga ggcatacgtt catggtgtca aaaaattact ctttctcggc
     2521 tctacctgca tctatccgaa aaatgcgtca cagccaatga aggagggttg ccttcttacc
     2581 aacgaactcg aatacaccaa cgaggagtac gccattgcta agattgcagg tctcaagatg
     2641 tgcgagtcat ataatctgca gtatggcact aattacattg ccgtaatgcc tacgaacctc
     2701 tacggtccga acgacaactt ccaccttgag aactctcacg ttatgccagc catgatgcgt
     2761 aaggtctatc tcgccaaact catcaacgat ggaaactggg aagcaattcg caaagatctc
     2821 agcatccgtc cagtaggagc taatatcaag gaaaatgatg agaaagttcg ttacatcatt
     2881 gatggcaata gttcagaggc agagattctt aaagttcttg ctttctacgg catcgaaaat
     2941 aacaaggttt ctctctgggg cacaggctta cctcttcgtg agtttctttg gagcgaggac
     3001 atggccgatg caagtgttca catccttctc aacgtcaact tttccgacat tatcggtgtt
     3061 gagaaatact catccgttca ctacggtaac aaggctgatg gagctgttga ccgtaatcac
     3121 tcaataggtc gaggaggagc catcccaaat cttggcgaga ttcgtaactg ccatatcaac
     3181 atcggcacag gtaaggaact tgctattcgt gaactttctg aacttgtagt caaatccgtt
     3241 ggtttcacag gaatcgtaga atttgatacc actaaacccg atggtactat gcgtaaactc
     3301 atcgatgtta gcaaactcca ttcattaggt tggactcata aagttgagat tgaggaaggc
     3361 gtgcaacgcc tgttctattg gtacacagag agtttgaaaa cttaaacgta atcaataata
     3421 aaaaaacata acatatttat gtcacagaac attgcactta tcactggcgt taccggtcag
     3481 gatggcagct acctttcaga gttccttctc gctaaaggtt acgaagttca cggcattatc
     3541 cgtcgttcgt cagttgattt ccgcgagcgt atcgcacacc tcgaaggcac tcctagtttt
     3601 cacctgcact atgcagacct taccgattca atgtcgcttg ttaagcttgt aggtatggtt
     3661 cagcctaccg agatttataa ccttgccgct cagtcgcatg tacaagtttc attcgatgct
     3721 ccagagttta ctgcagatgt cgatgctatc ggtgttctcc gtgtgctgga ggctgttcgt
     3781 actaaccacc ttgagaagac ttgtaaaatc tatcaggcat caacctctga actctatggt
     3841 aaggtagaag aagtccctca gaacgagaac acaccttttc acccttactc cccttatgct
     3901 gtggcaaagc tttatggttt ctggattgtt aaagaatatc gtgaggctta caacatgttc
     3961 tgctgttcgg gtattctttt taaccatgag tctgagcgtc gtggcgaaaa cttcgtcact
     4021 cgcaagatta cgttggctgc agcacgtatt gctcagggga agcaggattg cctttacctt
     4081 ggtaatcttg attcacttcg tgattggggt tatgcaaagg actatgtaga gtgcatgtgg
     4141 ctcatccttc agcacgagac tcctgaggat tttgttatcg ctacaggtgt tcagcatacc
     4201 gtacgtgagt ttgctactct cgctttccat tacgtaggta ttgaactatg ttgggatgga
     4261 gaaggtgtaa atgagaaggg aattgataca gcaactggta aggtggtaat cgctgtaagc
     4321 gaagatttct atcgtcctac cgatgtcgtt aatctttggg gcgatccaac caaagctaaa
     4381 aaggaactcg gctggaatcc tatgactact accttcgaag aacttgtcaa gattatggta
     4441 gattatgaca tgaagaagat tgctgctgat caagctgctt tcgaaatccg caaaatgaat
     4501 cttgcagagt atctcgaaaa gggtatcgtt aaataaatct aatggataag taaggggagc
     4561 gatgctggtg attgaacagt tgcttgctac aaaatcaccc caaggattat tagtatgaag
     4621 aagaaataga gagaattctt gaatgtgtag gacatacttt aaatataaaa gtaggtgata
     4681 taatcgtaag tagtcacttt agactggctt ttaaatagat gcaaaatatt ttgttttttt
     4741 atggggctaa atgagtactt gcagatgtgg agaaaagatt gtgttcggac taataagtag
     4801 aggaacctga aagttaagat gataaatagt atatgagtaa aaaagtttat gttgggatga
     4861 gtgctgatat cattcatccg gggcatctga atataattca tgaagcttca aaattaggtc
     4921 gcgttatagt aggagtttta actgatgaag ctatcgcaag ttacaaacga cttccttatt
     4981 taaattatga acaacgctct atggtagtgg gtagtttgaa aggagtagat gaagtaatac
     5041 ctcaggagac tttggattat gttccaaatc ttgaaaaaat gaggcctgac tatgttgtgc
     5101 atggtgatga ttggaaagaa ggtgtacaga aacaaacgcg tcagcgcgtg attgatacaa
     5161 tagcggcgtg gggaggaaaa gttgtggaca taccttatac aaaaggtata tcttctactc
     5221 aattaaattg taaacttaag gagataggaa ctactccaga agtacgtcaa aagagattaa
     5281 agcgcttgat tgctgctaaa tctattgttc gtattatgga atctcactgt ggattgactg
     5341 gcttaataat agaaaataca agtgtggatg taaatgggat taaacgtgag tttgatggga
     5401 tgtggtcaag tagtttgact gattcaacat cgaaaggcaa accggatatt gaagctgttg
     5461 atttgactac ccgtttacat gacttgaatg acacattgga atgtaccaca aagccgatta
     5521 tttttgatgg tgatacaggt ggcaaaatag aacattttgt gtttacagtt cgtactttag
     5581 agaggttggg tatttccgct ataattattg aagataaaat cggattgaaa aaaaattcat
     5641 tgtttggaac agatgcagtc caaacacagg attcaatcga agggttttgt gcgaagataa
     5701 aagctggtaa gcatgctcag gtggcagacg actttatgat tatagcccgg atagaaagcc
     5761 ttattgctgg caagccagta gctgatgcta ttgaaagggc gtatgcctac gtggaagcgg
     5821 gtgctgatgg aattatgatt catagtaagc ataagtctgg tgatgatatt aaagaatttt
     5881 gccaaatttt ccgtaagaga tatgcatcca ttcctataat agtggtacct accacttata
     5941 atcacataac agaggaggag ttgtcttctt ggggagtaaa tgtagtcatt tatgccaacc
     6001 atatgcttcg tagcgcatat cctgctatgg tgaatacggc taaatctatt cttctccata
     6061 gtcgttctta tgaggctaac gatatgtgta tgcctgtcaa agagatatta gaattgattc
     6121 ccggaactaa atagtgtttt ataatgattt cacctcgttt ttttgtggat tcccttgctg
     6181 ctatgcagat tgatttttat acgggtgtgc cagattcttt attaaagaat atttgtgcat
     6241 atataacaga ttgtttgccc aaggaaagta atgttattgc tgccaatgaa ggtggtgcta
     6301 tagggttagc ggctggctat tatctggcta cagcaaaaat acctgtagtt tatatgcaaa
     6361 attccggtga aggtaatgca gttaatccat tgatgtcatt gacggacaga gaagtttata
     6421 atattcctat tcttttactt attggatgga gaggcgaacc aggtgtaaaa gacgagccac
     6481 agcatgttaa acaggggaaa gtgacacttg aattactaga gaccatggga atcagatatg
     6541 aagtactttc catgaatgag acggaatgct taaatcagtt gaagaaggcc aaagcatata
     6601 tggaagaaac ctcagaaccc tttgctttag tcatcaagaa aggttctttt agtgaccact
     6661 tgcttcaaaa gaaaaaagat gagggggaag aatttgttcg ggaaactgct ataaagatag
     6721 tcgcttctta catggaatct gatgcagtgg cagtatctac tactggtatg attagccggg
     6781 aactttttga atacagagag agtgtgtatc aaagtcatca atgtgatttt cttactgtcg
     6841 gatctatggg acatgcttcg cagatagcct taggcattgc tttgcaaaag aaaaacagaa
     6901 aggtttattg ttttgatggt gatggagctt tgctgatgca tttaggttct attgcaatta
     6961 ttgcgtctat gcatcttgat aactatgtac atgtggtttt caataatggt gcgcatgata
     7021 gtgtaggggg gcaacctact gttgctttgg aaatagactt gcctcaaata gcactggctt
     7081 gcggttatgc tttggtattg tctgtagcag atgagggaac gttacacgaa gctttagaaa
     7141 aaataaaggg agcccatggt cctgtttttt tggaaataag agttaagaaa ggtgctcgta
     7201 aagatttggg acgtcctacc actacaccta ttcagaataa ggaagctctg atgaggttct
     7261 tattagagga gtaatacaga tgaaacagca ggcttttata ggaacagatt cctttagtaa
     7321 attattttta tgtttacaag aatattctcc aaatgaattg tttcttgtga gaggaaagca
     7381 ttcttatgaa tgttgtgggg ctaaagatga agtggataga gtagtttcca ttttgggatg
     7441 tagagtaatt gagttttccg attttcaaga aaatcctaaa attgaagata tggaaaaagg
     7501 tctggaactt ttacacacta ctaatgccaa tgttgtagta gctattggtg gaggaagtgt
     7561 acttgatatg gctaagctta tacgcttttt ctattcttat tcaggtaatc ctataggaag
     7621 gaattttaag aaagaaagag aactgctccc tttaatcgcc ttgccgacta cagcaggtac
     7681 gggtagtgaa gcgactcatt ttgccgttct ttataaagat aggataaagt attctgttga
     7741 gcatgatgat atattgcctg attatgcaat tatctattct ccttttacgt acagcaatga
     7801 taaatatttg acggcttgtt ctggatttga tgctttggcg caggctattg aggcgtattg
     7861 gaatgtgaat gcttgtgagg agtctgatga atatgcagaa aaagcgattt atttgctttg
     7921 gcagaatctg cccttggcag tgaatgctcc tacaaaagat atacgtgata aagtttcaga
     7981 aggtgcctat tgggcgggaa aggctatcaa tataactaaa acaacagcac ctcatgcttt
     8041 ttcttatcca tttaccactt actatggtta cccgcatggg catgcagtgg ctttagtctt
     8101 tccctatatt gctgctctta atttgaatat agaagctatg aacataagca aattatattc
     8161 tttgttaggt ataaatgatt cggagatggt ggaggatatt tttttagaat ttctgtctaa
     8221 tattggatta cagaaaagag agtgtgacat ttttgataat aagttgattt tggataatgt
     8281 aaatttgagc agactaaaaa ataatccagt tgttattaat aaagaaatgg caattaatct
     8341 gataaataga atatagaaat taatctgata aatagaaatg aaggttttag ttatatttat
     8401 agatatggtc agaacagacc ttatgttctt atataataat aaagcaaagg ccactccctt
     8461 tgatttatta attgagcaaa taggaggtac cttatttaca aattgctaca ctcctgcacc
     8521 tgatactcct cgaagccttg cttgtatgca aacaggactt cttcctacaa tgaatggttg
     8581 tgatagtaga attaagtggc cacaatttta tatagataaa tcaattgata caatgtggga
     8641 tttattgatt agaaataata tagaaataaa ttatttcaat caaaaatcgt cttatgagac
     8701 tggacccata tcgagaaaag ataaaactaa aataaaggtc tatcatttgt tagatgattt
     8761 taaaaaaaat atactttctg gctctactga agacgaatta gattatttaa cattaaatga
     8821 ttatcattgg tgtattgatg attatggtgg aacaataaat gcgactatta aggctaaatg
     8881 tatattagcg gagattctca aagagtattt tgtacagcat gatattaatg aatatgacca
     8941 tatttttata cattcagatc atggacattt attggacaag gaaatagcaa tacaaaaatc
     9001 agatttggaa taccttaatg atagtagaac taaaatatta atgtttcatc atcaaaaaaa
     9061 tgatcaaaaa gggcgtgtct cttataatcg taatttacac tctgtacaag atgtttttgc
     9121 aacaatgatg gaggtcttcc atatagatac agataagagg aattcatgtt ctcttttatc
     9181 tactcaagga catgatttta ttgtaataga agatcataat aattttgcag taacactgaa
     9241 tcagcgtatt cttctatgga gatatatttc aaaaggtggt ggttctttgt atacaaatat
     9301 atataatact agtatattag gtgatgtaga tcgagaaagt gccgtgaaat gcattaaaaa
     9361 gtattctcct tcatatattg attgtgaaaa gcaaatagaa atattgaata aatataaaca
     9421 attaaaatca gaacaaatat gttataataa tggaactaaa agacctggtt atggttggag
     9481 atttgctact aaagtgaaaa atagaataaa aagaagaatg ttaaaatggt tctattgaat
     9541 agatggaaaa ataagatagt agaagttgga ttagtaataa tgagtacttt aatagagcta
     9601 ataacttctc ttataattgt aaaactagcc gccatgtatt tagttaaggc tgattatggt
     9661 ttttattcac tgattctttc tatctttact ttgttctctt tattaccatt tacctctttg
     9721 catacaggta ttagtagata tattatagat gtcaagaaca aaggctattt gagccagcta
     9781 tatattcatt tttggggaat tcatctttca ttctttataa tctattcttt attatgttta
     9841 tttgcttata attttttatc ttccgcatgg aaagaactga tgtttttttt atttcttttt
     9901 tgctgcacaa aaatttataa acaatttctt ttttgtatct taaatacacg aagaaagagg
     9961 ggaagtgttg tattggggcg aataatagat ttggtaatag aagtttcatt aatattacta
    10021 tttgtatgtg atattttgac tataaagaaa cttctattct catcaatcat tggtagttta
    10081 tgtgttattt tattttttgt ttatatagaa aaaagcgatt tagttgtttc aaatataagg
    10141 atgactcgtt ttaaatacct tttaaaagaa atactctctt tttctactcc tttgattatt
    10201 tggggtattt ttgggtggtt acagtctatg gtggctagat ggtttatcga tagctatttg
    10261 tcaaaagaag atgttgcaaa ttttagcgct ttattctcta tggctttatt accagcaaca
    10321 gcacttttat ctattgtctc aaatttcttt actcctatat cgtatgaaca tgaatatcgt
    10381 atgaaaggaa caattaggat gtatgtacat agagtattga tttgggggac tttaatatgg
    10441 ggtatgctac ttttgttcgt atatctattg ggagattgga tgattgtttt atttttagac
    10501 gaaaaatatt taaatgttct accttattta ccctatgtga tgataggaac agggatatat
    10561 gctatggggc agatagctgt aatagaaatg tattattata aattgcaata taagcttctt
    10621 tttcctacaa tattgcctgg ttgcttaacg tttataggat gctatttgtt tattcaagat
    10681 tttggtatta aaggagccat tttaaacaat gcagtaacat atgctatata tgggatattg
    10741 tatataatat atgcttttta ttatagtaaa aagcttcgat tgaataacta ttgtatatga
    10801 atgaaagatt aattagtatt gttgttccaa tatataatgc agaaaaatat tttgctagat
    10861 gcttgaaatc tttgtttgag caagattatc taaatattga atatgtattt attaatgatt
    10921 gtactccaga taacagtatg aatatattaa atgatattct tgaagaatat cctatgcgtc
    10981 aaaaaaaaac taatattatt cataataaaa aaaacaaagg tatagctgaa actagaaata
    11041 ttggagtggc tgttgctacg ggagattata tattatttgt ggatagtgat gattatattg
    11101 ataccaatat ggtttcaaga ctttgtgagg tggcgataga gaatgataca gatatagtgc
    11161 tttgtaatca gattcttatt gaaagtgtaa aaggaaatga tgtgttaaat atatcttata
    11221 ctgataagcg tgaatacctt aataaagtcc ttcacggtca attcccttgt tgtatttggg
    11281 gaaaacttat caaaaaggcc ttgtttgtaa aacattctgt tgcggctatg ccaggcgtta
    11341 accatgggga ggatttgcag gttatgattc ctctttatta ttatgctcac aatattaatg
    11401 tggctgatac gacttatttt tataataagt ttaatgcatc ttcatatact aatactttaa
    11461 aaactgaagg aatagttagt atgataaagt catacaaaat ggtagctgat tttctatcta
    11521 ttcataatag ttttacatca gttgctgatt tgcaagaaag tactttaata cataaggttt
    11581 ctttactttc tgtggcttct gctcaagatt attcattggt tgctaaaata tatagagata
    11641 tacctatttg gacagttaat attggtattt catataagat tttattgatg ttggttgatt
    11701 ggggatggta taatgttgct tatggtgttg ttaaattgta tttaaaaata agataggatt
    11761 atgattattg cgaaattgtt tggcggcctt ggtaatcaaa tgtttattta tgcaacagca
    11821 aaagcacttg cactaaaaag cggtcaagat tattcgtttg atgttgtgac aggatttaaa
    11881 gatgattata aatttaagcg tgatttgttg ctgtcatatt ttcctgctgc tttaattgaa
    11941 gctcctcata aattatcatt tcaatatttt ggtggacgat tatttcgaaa aattagtcgt
    12001 tttcttggtt tttgtatccc tgtctttaat attcgattta tatgtgaaca acgtccatat
    12061 atttatcatt gcgaatactt tgatatggct aaaaaagggg aattatatat agaaggttat
    12121 tttcaatcgt ataggtattt tcattcgatt cggaaagaac ttttaaaaga tttttcattt
    12181 tcagaagacc tcaaattgtc tgtatcagat gaggcaaaac tgatttgtga tgatgaattt
    12241 gttccagtag ctatgggtgt acgtcgttat caagaaatga aaggtgaatt tggggaactg
    12301 actatagttc ctgcttcttt ttacgaacat gcagtaaatt gtataaagaa aaagattatt
    12361 aatcccaaat tgtttatttt tagtgaagat atgaattggg tacaaagtaa tctgcagttt
    12421 gatattcctg tttattatgt aaaaccaaaa tctggtaaac tttctgcatt gcaggatatg
    12481 tatcttatga gtatatgcaa tcatcatatt atatcaaata gtacttttta ttggtggggt
    12541 gcatatttat ctaataaaga aaataacata gttatagttc ctaataattt tttgaataga
    12601 gattgtacat tagaggaatg gatagtcatt gaatgacatt gaatgacatg gaatatattt
    12661 tgagtaatac aacttgcatt gtttcggcat tttgtcttct ttttctgaat agtatattta
    12721 gtaagcattg taggaaactg atattaagaa ggtctactaa ttcttttttt atagatttag
    12781 ttttttcact gtttgcactt cgtatattac tttattatgt cttaccatct atttctcgtg
    12841 taataattgg ttgggacaat caaaaacaag aaaatgttca gccatttgag gttagtatag
    12901 tctatcttgt agaactgatt tctcatttga tttattatta tactttttat tggttgtgta
    12961 aaagaacaaa atatgattat tcttttgtga accaaaatag tagttctctg aaagttattg
    13021 ttatttctat attattattg tatgcttgtt tcctagttca tggtacggga attatagtga
    13081 taccattttg tgactcgcta tggatgattc agcctttcgt tatgtcaacg ggctctgtag
    13141 catgttttta ttttttagct ataggtcgta aattgagtgg caagtgggtt cttgtagttt
    13201 cgtgtattgt cattattata tatatattga caggtttggc gagtggaatt agaggaaaat
    13261 tgttttggcc tgtcttttgg atgctttttt gtgcctacca tattaataga aaacgaatta
    13321 aaatgatgtt ttatttggga ggtggtatat tattgg
//
