LOCUS       c00031_gnlPro..        14565 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|FIDHCELB_31.
ACCESSION   c00031_gnlPro..
VERSION     c00031_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-07 05:20:14
            Original ID  :: gnl|Prokka|FIDHCELB_31
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14565
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14565
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[6:4565]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      7..4565
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..14565
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14565
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             complement(7..1167)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg31_1"
                     /sec_met_domain="OAD_beta (E-value: 7e-153, bitscore:
                     500.7, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGDFINFLGNNLADFWTYTGFANATGGHIAMIIIGLGFIYLAVAK
                     EFEPMLLIPIGFGILIGNIPFNMDAGLKVGIYEEGSVLNILYQGVTSGWYPPLIFLGIG
                     AMTDFSALISNPKLMLIGAAAQFGIFGAYMIALEMGFDPMQAGAIGIIGGADGPTAIFL
                     SSKLAPNLMGAIAVSAYSYMALVPVIQPPIMRLLTTKHERVIRMKPPRAVSHTEKVIFP
                     IIGLLLTCFLVPSGLPLLGMLFFGNLLKESGVTRRLANTASGPLIDVITILLGLTVGAS
                     TQASEFLTLDSIKIFALGALSFIIATASGVIFVKIFNLFLKKGNKINPLIGNAGVSAVP
                     DSARISQVVGLEYDPTNYLLMHAMGPNVAGVIGSAVAAGILLGFLM"
     CDS             complement(1169..1600)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 67.6; E-value:
                     2.2e-21)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg31_2"
                     /sec_met_domain="Biotin_lipoyl (E-value: 2.3e-21, bitscore:
                     67.6, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKEYKYKINGNLYKVTIGDIEDNIAHVEVNGTHYKVEMEKQPKPV
                     AKPVTVRPMPNAPTAPTQVVKPTAPSTGKSGVKSPLPGVILDIKVNVGDTVKKGQTIII
                     LEAMKMENNINADKDGKVTAINVNKGDSVLEGNDLVIIE"
     CDS             complement(1625..2545)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg31_3"
                     /sec_met_domain="OAD_gamma (E-value: 1.9e-14, bitscore:
                     46.2, seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKTKIGIFLSLLLLIGLTSCGEQKSNNKLVLNEILIDNQSNFQD
                     DYGLHSAWIEIFNKSFGSADLAACLLKVSNQPGDTVTYFIPKGDILTSVKPRQHALFWA
                     DGEPNRGTFHTSFKLNPKTANWIGLFDSGKKLLDQIVVPAGTLGPNQSYARVSDGATEW
                     EVKSGSGDKYVTPSTNNKTLDSNAKKEKFEEHDANGIGMAISAMSVVFCGLILLFIAFK
                     IIGKAAVNLSKRNAMKSKGIDKHEAKELSQAPGEVYAAISMALHEMQDEVHDVEETVLT
                     ITRVKRSYSPWSSKIYTLRETPSRK"
     CDS             complement(2577..4130)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Btheta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg31_4"
                     /sec_met_domain="CT_Btheta (E-value: 5.4e-290, bitscore:
                     953.9, seeds: 72, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNQLEKIKELIERRAVARIGGGEKAIAKQHEKGKYTARERLAML
                     LDEGSFEEMDMFVEHRCTNFGMEKKHYPGDGVVTGCGTIEGRLVYLFAQDFTVTAGSLS
                     ETMSLKICKIMDQAMKMGAPCIGINDSGGARIQEGINALAGYAEIFQRNILASGVIPQI
                     SGIFGPCAGGAVYSPALTDFTLMMEGTSYMFLTGPKVVKTVTGEDVSQENLGGASVHST
                     KSGVTHFTAKTEEEGLALIRTLLSYIPQNNLEEAPYVDCTDPIDRLEDSLNDIIPDSPN
                     KPYDMYEVISAIVDNGEFLEIQKDYAKNIIIGFARFNGQSVGIVANQPKFLAGVLDSNA
                     SRKGARFVRFCDAFNIPIVSLVDVPGFLPGTGQEYNGVILHGAKLLYAYGEATVPKVTI
                     TLRKSYGGSHIVMSCKQLRGDMNYAWPTAEIAVMGGAGAVEVLYAREAKDQENPAQFLA
                     EKEAEYTKLFANPYNAAKYGYIDDVIEPRNTRFRVIRALQQLQTKKLSNPAKKHGNIPL
                     "
     CDS             complement(4161..4565)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Glyoxalase_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg31_5"
                     /sec_met_domain="Glyoxalase_4 (E-value: 7e-24, bitscore:
                     76.4, seeds: 51, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKISHIEHLGIAVKSIEEALPYYENVLGLKCYNIETVEDQKVRTA
                     FLKVGETKIELLEPTCPESTIAKFIENKGAGVHHVAFAVEDGVANALAEAESKEIRLID
                     KAPRKGAEGLNIAFLHPKSTLGVLTELCEH"
     CDS             complement(4739..5737)
                     /locus_tag="ctg31_6"
                     /transl_table=11
                     /translation="MPLKLTTYYRGKDIPDLPGTNTFHSKELFQIYESTPGYTPLLIVA
                     TEEGRPVARLLAAIRKTKKWLPSSLVKQCVVYGAGEFLDTSLPASKEKEEEIFGEMLEH
                     LTQEASRTCILIEFRNLDNSMFGYRFFRKNDFFPVNWLRVRNSLHSTQKAEDRFSPSRI
                     RQIRKGLKNGAKVVEAHTVEEIKEFSRMLHKVYSSRIRRYFPANDFFRHMNSMLIRGKQ
                     AKIFIVKYKEKIIGGSVCIYSGENAFIWFSGGMRKTYALQSPGILAVWKALEDAHERGF
                     RHMEFMDVGLPFRKHGYRDFVLRFGGKQSSTRRWFRISWSWLNNLLVKFYV"
     CDS             5986..9180
                     /locus_tag="ctg31_7"
                     /transl_table=11
                     /translation="MRENAFVEAWKTQHRRVSMILGLTLLCAPSAISVYAENGVNDITV
                     QAVMQTKTVKGTVLDENGEPLIGVSIVVKGTSTGTITDFDGKFSINLPAGSKELVVSYI
                     GYKEQAIIVSGNAPLNIKMVPDTQALDEVVVIGYGTVKKRDLTGAVASVKSEDITMNPG
                     VNPMDALQGKIAGLDITNSSGQAGSSPTVQLRGTRSLQLDEDGNISSDAFKPTYIIDGM
                     PGDIATLNPNDIESIEVLKDASSTAIYGSSGANGVIIVTTKGSKSGKPVINFNAYAGTT
                     MGARVPKMRTGDSYINYIKDSYKPVGTTNEEEIFGERYDAIKNNQWVNWGDEVLHSGLK
                     QNYSISVAGGTEKTKAYFSLNYTDEKSMYENDDYKVYSTRVRIDQEINKWMNAGINVQA
                     SFSNKNSRNAVLERALFATPLGTPYNEDGSITEFPIPGSSSDPNPLADEQDGVYKNNTK
                     AGRAYVDAYLEWKPVKGLSVKSQLGGSYSQSRAGKFMGEGSYNVLKGSTVAYGEATNKT
                     GYNYKWENIVTYHNTFNKDHDLTVTGVTSWNYNQSEEYYVYGENPATNDMLWYALQNAD
                     NKKLNSKYLMSKGMGFIGRVNYSYKGKYLFSASSRYEADSRLSKDNRWNLFPAVSVGWR
                     ISDEAFMAGTKSWLDNLKLRVGYGVAGTTAGIAEYSSMASLENVTTSLGGMTVPSAKFT
                     EYITNRNLTWEKTHDLNIGIDASFLNNRIDLTVDLYRTKTTDVILSQALPTSIMGNYTG
                     STTYKMNKNAAETENRGIELALNTRNIVKKDFTWSSTVTFTANKEKIKSLIEGQDMMFN
                     AKKGDMVFKVGEGVGSFYRYKVLGIWQYSEKETAALFGCEPGDIKLDLPSVKKDGNGYY
                     YMNPEGERVDITAENPYGVRADYDRQVIGRNTPDWTLGFKNNFRYKDFDLSVFLYARWG
                     QMMNYGSVIGKYSPNPDYNIPTYFTYYDKTIEADQDVLFYAIDKSKDRSAYEGYDSMYY
                     VDGSFFKLKNVTLGYTLPGKLTKRFGISNLRVYATMTNLFTYSPNKYVKNYDPEMNGSI
                     NFPLSRDCIFGLNLTF"
     CDS             9192..11147
                     /locus_tag="ctg31_8"
                     /transl_table=11
                     /translation="MKKIYSLVLLVAGVFSWGSCSLDEVNPNNSGQFSDGSYTLETYKA
                     FTNSCYTALINNIYQSSDYLVCTEAGTDIWEEPKSGSSYQRYHSYNGMKTDDSYYYKVW
                     QYSYLCINSCNIVIDGAENVTGDETEINECVAQARCLRAYYYMNLVEQFGNVDLQLKAA
                     DSENISFDAHRSTVPEIYAAIIEDLKFAVENLPVSFSDYYSRVTKKSAMGLLARAYING
                     AGYDLKDTDGVSFLEKAYDTATTMINNKAIYEWYMHPAFADVFNENNNRNNEEALFIAA
                     GAERNSDAYTNGNYSQSEMFRHFLPSLGTYTDLGLVDKTSNFVYGRPNSNIFLPSKYLM
                     DCFAADMNDSRFRYSFISAYSSYSIPAWGATYEYGGSACAKEITSTLATKFGIPASNIG
                     KKVYPHFNLESNSTADANYCQLAIWNADGTAKTTQDKTDGNILHPAMPLDPAEAHQYAV
                     YCSLKTLTEEEKAQYPGLVLNVFDLYDENGTARATYDKPSAASALWLSIYPALSKFNMP
                     GNKFVGRDVQRKTVDVMIMRMAEVYLIAAEASVRLNKGDAAKYINVLRTRAGAGTVSES
                     QVDLNYIFDEYARELCGECARWYLLKRNAAFETRLAAYNKRAAEHFKKEFYLRPIPTKY
                     LDAINNPAEFGQNAGY"
     CDS             11334..11876
                     /locus_tag="ctg31_9"
                     /transl_table=11
                     /translation="MIEEMLAYNREFVKNEGYKEYITNKYPDKKIAILSCMDTRLTALL
                     PAALGIKNGDVKMIKNAGGVISHPFGSVIRSLLVAIFELGVEEIMVIAHSDCGACHMHS
                     EEMLEKMKARGINADYIHMMSFCGVDFHSWLDGFEDTEKSVRGTVDFIVHHPLIPSDVK
                     VHGFIIDSTTGELTRIV"
     CDS             complement(11990..12175)
                     /locus_tag="ctg31_10"
                     /transl_table=11
                     /translation="MKKRITQDDYIKANRKASREAEIKEHGHPVCYKRVHESKKVYNRR
                     KIKAADKKLPYFFHLG"
     CDS             12275..12811
                     /locus_tag="ctg31_11"
                     /transl_table=11
                     /translation="MENFSELIKNRRSMRKFTDEELTQDEVVALMKAALMSPSSKRSNS
                     WQFVVVDDKEKLKELSHCKEQASSFIADAALAIVVMADPLASDVWIEDASIASIMIQLQ
                     AEDLGLGSCWVQVRERFTATGMPSDEFVHGILDIPLQLQILSVIAIGHKGMERKPFNEE
                     HLQWEKIHINKFGGK"
     CDS             12814..13149
                     /locus_tag="ctg31_12"
                     /transl_table=11
                     /translation="MGAVKANNNKDTYKATAVAFIVIGTLFLINKLLPFASIGLPWVMN
                     KDNLLLYASISFLIFKRDKSVGFVLLGLWLVMNIGLVMSLLGSLSGYLLPLALLIIGII
                     LFWVSKR"
     CDS             13157..13951
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) F420_oxidored"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg31_13"
                     /sec_met_domain="F420_oxidored (E-value: 2.4e-13, bitscore:
                     42.7, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRSIEDTPVVFLGAGNLATNLAKALYRKGFRIMQVYSRTEESAR
                     TLANEVEAEYITDLKDVSNEARLYIISLKDAAFVELLPQITDGKQHALLVHTAGSIPMN
                     IWEGHAERYGVFYPMQTFSKQREVDFREVPFFIEAKRPEDTELLKAVAGTLSDKVYEAD
                     SEQRRSLHLAAVFTCNFTNHMYALAAELLEKYHLPFDVMLPLIDETARKVHELAPRDAQ
                     TGPAVRYDENVMNKHLSMLADSQALQEIYKLMSKSIHEHHQL"
     CDS             13932..14453
                     /locus_tag="ctg31_14"
                     /transl_table=11
                     /translation="MSTINYDLSRIKALAFDVDGVLSSTTVPLHPSGEPMRTVNIKDGY
                     AIQLAVKKGLHIAIITGGRTEAVRIRFAALGVKDLYMGSAVKIHDYRNFRDKYGLSDDE
                     ILYMGDDVPDIEVMRECGLPCCPKDAVPEVKSVAKYISYADGGRGCGRDVVEQVLKAHG
                     KWMAEDAFGW"
ORIGIN
        1 ttgtccctac attaagaatc ctaacaggat accggcagca acagccgaac cgattacacc
       61 tgctacgttc ggacccatag cgtgcatcag caagtagttg gtaggatcat attccagacc
      121 gacaacttgt gagatacgtg cagagtcggg aacggcagat acacctgcat taccgatcaa
      181 cggattgatc ttattgccct tcttgaggaa gaggttgaag atcttaacga agatcacacc
      241 tgatgcagta gcaataataa atgacaaagc accgagggcg aagatcttga tggagtcgag
      301 tgtcaggaac tcagaagcct gagtagaagc acctactgtc aaacctaaca ggatagtgat
      361 aacgtcaatc agcggaccgc tggctgtgtt agccagacga cgggttacac cactttcttt
      421 caacaggtta ccgaagaaca gcatacccaa cagaggcaga ccggaaggaa ctaggaagca
      481 ggtcagcaac agaccgataa tcgggaaaat cactttctct gtatgagaaa cggcacgtgg
      541 cggtttcata cggataacgc gttcgtgttt ggtggtgagc agacgcatga taggcggctg
      601 tatcaccgga actaacgcca tataggagta ggcggatacc gcaatggctc ccattaagtt
      661 aggtgccagc ttggacgaaa ggaagatagc cgtcggacca tctgctccac cgatgatacc
      721 gatagcaccg gcctgcatcg ggtcaaatcc catttccaat gcgatcatgt atgcaccgaa
      781 gataccaaac tgggcagccg caccgatcag catcagcttc ggattggaga ttagcgccga
      841 gaagtctgtc atggcaccga tacctaagaa gatgagcggt ggataccagc cggacgttac
      901 tccctgatac aatatgttca atacagaacc ttcttcatat ataccgactt ttagtccggc
      961 gtccatattg aaaggtatat taccgatcag aataccgaat ccgataggaa ttaacaacat
     1021 cggctcgaac tctttggcta cagctaagta aataaagcct aaaccgataa tgatcatagc
     1081 aatatgtcca cctgtcgcgt tggcaaatcc cgtgtaggtc cagaaatcgg caaggttatt
     1141 tcctaaaaag ttaataaaat ctcccatatt attcaataat tacgaggtca ttaccttcaa
     1201 gaacagaatc tcccttattt acgttgatgg cagtaacctt accgtcttta tccgcattga
     1261 tattgttttc catcttcatg gcttccaata tgataatggt ctgtcctttc tttacagtat
     1321 cgcctacatt cactttgatg tcgaggatca cacccggcag cggagatttc actcctgatt
     1381 ttccggtaga tggagcggtc ggtttcacta cttgagtagg agcagtagga gcattaggca
     1441 tcgggcgtac tgtcacaggt tttgcaacag gcttcggctg tttctccatt tctactttat
     1501 agtgtgtacc gttcacttct acatgagcga tgttgtcttc aatatctccg atggttactt
     1561 tatataagtt accgttgatt ttatatttat attctttcat cgtttttact ttttaaaagg
     1621 tgacttactt tctggaagga gtttcacgca acgtgtaaat cttcgaactc catggtgagt
     1681 agctgcgttt tacacgagtg atggtcagca ctgtttcttc tacgtcatgc acttcatctt
     1741 gcatttcgtg taatgccata gaaatagccg catacacttc gcccggagct tgtgacagtt
     1801 ccttagcttc atgcttgtcg atgcctttag atttcatagc gttgcgcttg ctcaaattaa
     1861 cggctgcttt tcctataatc ttgaaggcta taaaaagaag aatcaatccg cagaatacta
     1921 cactcatggc agaaatggcc attccaatac cattagcatc gtgttcttca aacttttcct
     1981 tcttggcatt gctgtcaagg gttttgttgt tagtgcttgg agtcacgtat ttgtcaccac
     2041 ttccactttt tacttcccat tcagttgctc cgtcgcttac acgagcgtat gattggttgg
     2101 gaccgagagt gcctgcgggc actacaatct ggtcgagcaa ctttttgccg gagtcgaaca
     2161 gaccaatcca gttggcggtt ttcggattca gcttgaagct ggtgtggaac gtaccgcggt
     2221 tgggttcgcc atctgcccag aatagcgcat gttggcgtgg tttcacagat gtaagtatat
     2281 cacctttcgg gataaagtaa gtaactgtat cgcccggttg gttgcttact ttcagcaagc
     2341 aagctgccaa gtcggcgcta ccgaatgatt tattgaatat ttcaatccat gcgctgtgca
     2401 atccgtaatc gtcctgaaaa ttactctgat tgtctatcag gatttcgttt agcaccagct
     2461 tattgttcga cttttgctct ccacaagaag tcagaccaat cagcaacagc aaagaaagga
     2521 atattccgat tttggttttg ttcataatcg ttcttgtttt aatgtgaaaa gttggattac
     2581 aacggaatat taccatgttt cttcgccgga ttagacagtt tcttagtctg caactgctgc
     2641 aaagcacgga tcacgcggaa acgtgtgtta cggggttcga tgacatcatc gatgtaacca
     2701 tacttagctg cattataagg gttggcaaac agttttgtat attctgcttc tttttcggca
     2761 aggaactgag ccggattttc ctggtctttg gcttcacgcg cgtacaatac ttctactgca
     2821 cctgcaccac ccattacagc gatttcagct gttggccaag catagttcat gtcaccacga
     2881 agttgtttac aactcatcac gatgtgagaa ccaccgtaag atttacgcaa tgtgattgtt
     2941 actttaggta cagtagcttc accgtaagca tacagcagtt tggcaccatg aaggataacg
     3001 ccattgtatt cctggcctgt tcccggaagg aatcccggta cgtctaccaa cgacacgata
     3061 gggatattga aagcatcgca gaaacgaacg aaacgtgcgc ctttgcgaga tgcgttgctg
     3121 tcgagtacac cggcaaggaa tttaggctga ttggctacaa tacctacaga ctgaccgttg
     3181 aaacgggcaa aaccgataat gatattcttg gcatagtctt tctggatttc caggaattcg
     3241 ccgttgtcta cgatagcgct gataacctcg tacatatcat acggtttgtt ggggctgtcg
     3301 gggataatat cgttcagtga atcttccaga cggtcgatcg gatctgtgca atccacatat
     3361 ggagcttctt cgaggttgtt ttgaggaata tagctcagaa gtgtgcggat caatgccaga
     3421 ccttcttctt ctgttttggc agtgaaatga gtaacacccg atttggtaga gtgaacgctt
     3481 gctccgccga ggttttcctg gcttacgtct tcaccggtta cagttttcac aactttcgga
     3541 cctgtaagga acatataaga agtaccttcc atcatcagtg tgaagtctgt cagtgccgga
     3601 gaataaacag caccgccggc acaaggaccg aagataccgg aaatctgcgg aatgacaccc
     3661 gaagcgagga tattgcgctg gaagatttct gcgtaacctg ccaaagcgtt aataccttcc
     3721 tggatacgtg caccgcccga gtcattgata ccgatacaag gagcacccat cttcattgcc
     3781 tgatccataa tcttacagat cttcagtgac attgtttccg acagtgaacc tgcagtaacg
     3841 gtaaagtcct gtgcaaaaag atatacgaga cgaccttcga tagtaccgca accggttact
     3901 acaccatcac ccggatagtg ctttttctcc atgccgaagt tcgtgcatct gtgctcaacg
     3961 aacatgtcca tttcttcgaa gctaccctcg tcaagcagca tagccagacg ctcgcgtgct
     4021 gtgtattttc ctttttcgtg ttgcttcgca attgcttttt caccgcctcc gatacgtgct
     4081 acggcacggc gttcaataag ctctttaatt ttttcaagtt gattactcat gagttcttgt
     4141 tgttttttta gagtttatga ttagtgttcg cagagttctg tcagcacacc cagtgttgat
     4201 ttcgggtgaa ggaaagcgat gttcagacct tcggcacctt tgcggggagc cttgtcaatc
     4261 agacggattt ctttgctttc tgcttctgcc aaagcattag ctacgccatc ttctacggca
     4321 aatgctacgt gatgaacacc tgcacctttg ttttcaataa atttagcaat ggtgctttcg
     4381 gggcaagtcg gctccaacaa ttcgattttt gtttcaccta cctttaaaaa agcggttctt
     4441 actttttgat cttctactgt ttcgatgttg taacatttca gacccaatac gttttcgtag
     4501 taaggaaggg cttcttcgat gctttttaca gcaatgccca gatgctcaat gtgtgaaatc
     4561 ttcataacta tattttttta tatggtttaa ttatgtgctt atatggcata aaacagcaca
     4621 aagaaagaca tttcttgtct aataaagaaa tatttctgca tttaattatt ggggaataaa
     4681 gcataaaaaa tgctccggat gggtgacaaa gacgggtttt gtaatcttga gattacattt
     4741 agacataaaa cttgaccaga agattattca gccatgacca gctgatacgg aaccagcggc
     4801 gggtactgct ttgtttgcct ccgaaacgga gtacgaaatc acgataacca tgcttgcgga
     4861 agggaagtcc tacatccatg aactccatgt gacggaatcc ccgttcatgg gcatcttcaa
     4921 gtgctttcca tactgccagt atgccgggtg actgcagtgc ataggtcttt cgcattcctc
     4981 ctgaaaacca gataaaagca ttttcgccgg aatagatgca gacggagccg ccgataatct
     5041 tttccttgta ttttacgatg aatatttttg cctgttttcc tctgataagc atgctgttca
     5101 tgtggcggaa aaagtcattg gcagggaaat atctccgtat tcgtgaagaa taaactttgt
     5161 gcagcatccg cgagaattcc ttaatctctt ccaccgtatg ggcttctact actttggctc
     5221 cgtttttgag ccctttccgg atctgacgga tacgtgatgg gctgaaacgg tcttccgctt
     5281 tctgcgtact atgcagagag ttacggacac gcagccagtt gaccggaaaa aagtcgttct
     5341 ttcggaagaa acggtaaccg aacatggaat tatccagatt gcggaattca ataagaatgc
     5401 aggtgcgtga tgcttcttgt gtgagatgct ccagcatttc accgaaaatt tcttcctcct
     5461 tctctttact tgccggtaga gaagtgtcca gaaattcacc tgcaccatat accacacatt
     5521 gtttgacaag agaggaggga agccactttt tggtcttgcg tatggcggca agcaggcgtg
     5581 ctacaggtct gccttcttct gttgccacta tcagtagcgg ggtatatccc ggagtcgatt
     5641 catagatctg aaacaactcc ttggaatgaa aagtattggt tcccggtaaa tcaggaatgt
     5701 cttttccgcg ataatatgtt gttagtttaa gtggcatcca aatacaaatt tacacttttt
     5761 attcttcatt caacaataaa aaagagaatt tgttggctta gcctaaaatt tgtcttttta
     5821 tcctttgcat atatttgagg aaaaaaaggc ttggaaaagc gaatttttgt attattgtcg
     5881 tcctttgtga gtacagaagt aaaatggaaa cgtctatata aaagattatg ctaattgtat
     5941 tttactaaac aaaggaaaat taatattaac tttaaattaa aacgaatgag agagaatgca
     6001 tttgttgaag cgtggaagac acagcataga cgcgtttcca tgattttagg gctgacttta
     6061 ttgtgtgccc cttctgccat atctgtttat gcagaaaatg gtgtgaatga tattactgtg
     6121 caagccgtca tgcagacaaa gacagtgaaa ggaactgttt tagatgaaaa tggagaaccg
     6181 ttgatcggtg tttctattgt ggtgaaaggt acaagtacag gtacgataac tgattttgac
     6241 ggtaagttct ccattaatct tccggccgga agtaaagaac tggttgtttc ttatatcgga
     6301 tataaagaac aggctatcat tgtgagcgga aatgccccgc tgaatataaa gatggttccg
     6361 gatacacagg ctttggatga ggtagtggtc atcggttacg gtacggtaaa gaaacgtgat
     6421 ttgacaggtg cggttgcttc tgtgaaatca gaggatatca ccatgaatcc gggcgtgaat
     6481 ccgatggatg cgctgcaagg taaaattgca ggtctggata tcactaattc ttcaggtcag
     6541 gcaggttcgt caccgacagt tcagttgcgt ggtacccgct ctttacagtt ggatgaggat
     6601 ggtaatatct cttcagatgc atttaagccg acttatatta tcgatggtat gccgggtgat
     6661 attgctacct tgaatcccaa tgatattgaa tctatcgaag tactgaaaga tgcatcttct
     6721 acagctatct acggttcaag tggtgcgaat ggtgttatta tcgtgactac gaaaggatcc
     6781 aagagtggaa aaccggtcat caattttaat gcttatgccg gaacgactat gggtgcccga
     6841 gttcctaaga tgcgtacggg tgactcatac attaattata taaaagattc ttataagcct
     6901 gtcggtacta ctaatgagga ggaaattttc ggtgaaagat acgatgccat caaaaacaac
     6961 caatgggtaa actggggaga tgaagtatta cactcaggtt tgaagcagaa ttatagtatt
     7021 tccgttgccg gaggtactga gaagacgaaa gcctatttct cgttgaacta tactgatgag
     7081 aagagtatgt atgagaatga tgactataaa gtgtactcta cccgtgtccg tatagatcag
     7141 gaaatcaata aatggatgaa tgccggtatt aatgttcagg catctttctc caacaagaat
     7201 tcacgtaatg ccgttttgga aagagcattg tttgccaccc cgttaggtac tccttataat
     7261 gaagacggct ctatcacgga attcccgatt ccaggttcat catcagaccc gaatccgtta
     7321 gcagacgaac aggatggagt atataagaat aatactaaag caggaagggc ttatgttgac
     7381 gcttatcttg aatggaaacc ggtaaaagga ttgtctgtca agtcacagct tggaggcagt
     7441 tattctcaat ctcgtgccgg taaatttatg ggagaaggct cctataatgt gttgaaaggc
     7501 agtacggtgg catatggcga agctaccaat aagacgggat ataattacaa atgggaaaac
     7561 atagtaactt atcacaatac atttaataag gatcatgacc tgacggttac aggggttact
     7621 tcctggaatt acaatcagag tgaagaatat tatgtctatg gtgaaaaccc ggcgaccaat
     7681 gatatgttgt ggtatgcatt gcagaatgct gataataaga aactgaacag caaatatctg
     7741 atgtcgaaag ggatgggctt tatcggtcgt gtcaactact catacaaagg taaatacctg
     7801 ttttctgctt ccagtcgtta tgaagcggat tcccgtttgt cgaaagacaa tagatggaat
     7861 ttattcccgg cagtttctgt aggctggaga atctcggatg aagcatttat ggctggtaca
     7921 aaaagctggt tggataactt gaaactgcgt gtaggctatg gtgttgccgg aactactgcc
     7981 ggtattgctg aatacagttc tatggcatct ttggaaaatg tgacaacctc tttgggagga
     8041 atgactgttc cgtcagccaa gtttacggag tatatcacta accgtaatct gacatgggaa
     8101 aagactcatg acttgaatat tggtattgac gccagcttcc tcaataatcg tattgatctg
     8161 acggtggatt tgtatcggac aaaaacaacg gatgtaattc tttctcaggc attgccgaca
     8221 tctattatgg gtaattacac aggtagcact acttataaaa tgaacaagaa tgctgctgaa
     8281 acagaaaatc gcggtattga acttgctctt aatactcgta atattgtgaa gaaagatttt
     8341 acttggagct caacagtgac atttaccgcc aacaaagaaa aaattaaatc tttgatcgaa
     8401 gggcaggata tgatgttcaa tgcaaaaaag ggtgatatgg tgttcaaagt cggcgaagga
     8461 gtcggttctt tctatagata taaagtgttg ggtatctggc aatatagcga aaaggaaact
     8521 gctgctttgt tcggatgcga accgggcgat attaagctgg atttacctag tgtgaagaag
     8581 gacggaaatg gttattatta tatgaatcct gaaggagagc gcgttgatat tacggcagaa
     8641 aatccttatg gtgtacgtgc ggattatgat cgtcaggtaa taggtcgtaa tactccggac
     8701 tggacattgg gctttaagaa taatttcaga tacaaagatt ttgatttgtc tgtcttcctt
     8761 tatgcacgtt gggggcaaat gatgaactat ggtagtgtga taggtaaata ttcgcctaat
     8821 ccggattaca atattcctac ttattttact tactatgaca agacgatcga agcagatcag
     8881 gatgtcttgt tctatgctat cgataaatcc aaggatagaa gtgcttatga aggatatgat
     8941 tcgatgtatt atgtggatgg atcattcttt aaacttaaaa acgtaacatt gggttatacg
     9001 ttacccggta aacttacaaa acgttttggt atcagtaatc tgagagttta tgcgacaatg
     9061 accaacctgt ttacttattc gccaaacaaa tatgtgaaga attacgatcc ggaaatgaac
     9121 ggaagcatca acttcccatt gtctcgtgat tgcatatttg gtcttaattt aactttctaa
     9181 aaaatagcaa tatgaaaaag atatatagtt tagttctact tgttgccggt gttttttctt
     9241 ggggctcttg cagtcttgat gaagtgaacc ccaacaactc gggtcagttc tccgatggtt
     9301 cttatacatt ggaaacttat aaggcattca ccaactcgtg ctatacagcc ttgatcaaca
     9361 acatctatca gagtagtgac tatctggttt gtacggaagc gggtactgat atttgggaag
     9421 aacctaaatc gggctccagc tatcagcgtt atcatagtta taacggtatg aaaaccgatg
     9481 atagctatta ttataaagtg tggcaatatt cttatctgtg tatcaacagc tgtaatattg
     9541 tgattgacgg agctgagaat gtgacagggg atgagactga aattaatgaa tgtgtggcac
     9601 aggccagatg tctgcgtgct tactattata tgaatctggt ggagcagttt ggaaatgtcg
     9661 atttgcagtt gaaggctgcc gatagcgaga atatttcttt tgatgctcac cgttctaccg
     9721 ttcccgaaat ttatgctgcc attatcgaag acctgaagtt tgccgtagag aatctgcctg
     9781 taagtttcag tgattactat agccgcgtta caaagaaatc ggcgatggga ttattggcac
     9841 gtgcatatat taatggtgcc ggttatgatc tgaaagatac cgatggtgtc agctttctgg
     9901 aaaaagccta tgatacggcg acaaccatga ttaataataa agcgatttat gagtggtata
     9961 tgcatcctgc ttttgccgat gtattcaacg aaaataataa tcgtaacaat gaagaagctc
    10021 tgttcattgc tgcgggtgcc gaaagaaatt cggacgctta caccaatggt aactactcac
    10081 aaagtgaaat gttccgtcac ttcttacctt cgttgggaac atatacggat ctgggtttgg
    10141 tagacaagac ttcaaacttc gtttacggtc gtccgaacag taatatcttc ctgccatcca
    10201 aatatctgat ggactgtttt gctgctgata tgaacgactc tcgttttcgt tattcattta
    10261 tttcagctta ctcgtcttat tctataccgg catggggggc gacttatgaa tatggaggtt
    10321 cagcgtgtgc caaagaaatc acaagcacac ttgctactaa atttggtatt cccgcatcta
    10381 atataggtaa gaaagtttat cctcatttta acttggaatc caatagtaca gccgatgcta
    10441 attactgcca gctggctatc tggaatgcag atggaacagc gaagactact caggataaaa
    10501 cagatggtaa tattcttcat cctgctatgc ctttagatcc ggcagaagct catcaatatg
    10561 ccgtttattg ttctttgaag acgctgacag aagaggaaaa agctcaatat ccggggttgg
    10621 ttcttaatgt tttcgatctt tacgatgaga atggaacagc cagggctacc tatgacaagc
    10681 ctagtgctgc cagtgctttg tggttatcta tttatccggc tctttctaaa ttcaatatgc
    10741 cgggtaataa gtttgtcggc agagacgttc agagaaaaac tgtggatgtg atgatcatgc
    10801 gtatggcgga agtttacctg attgctgctg aagcatcggt acgcttgaac aagggagatg
    10861 ctgccaaata tattaatgta ctccgtacgc gtgccggtgc cggtacggtc agtgagtcgc
    10921 aagtggatct gaattatatt ttcgatgaat atgcccgtga actttgtggc gaatgtgccc
    10981 gctggtattt gctgaaacgt aatgctgctt ttgagactcg tttggctgct tataataagc
    11041 gtgctgctga gcactttaag aaagaattct atttgcgtcc tattcctacg aaatatctgg
    11101 atgcgatcaa taatccggca gaattcggac aaaacgccgg ttattaatca gttaattaat
    11161 aatcaagcat aattaatagg agccgggcag gagatttttc ttgtccggct ctttgtttcc
    11221 atacctgtat cctgcgtaaa agtttaaaaa ggatttccgg tatattttca ttgtttcctg
    11281 atacagcttt ttattatttt ctttattttt gtgtgtccaa acaaaatagc gctatgatag
    11341 aagaaatgct tgcttataac agagagttcg ttaagaacga gggatataaa gaatatataa
    11401 cgaataagta tcccgataaa aagattgcta tcttatcctg tatggataca cgtctgacag
    11461 ctttactccc ggccgcacta ggcattaaga acggagacgt taaaatgatc aagaatgcag
    11521 gaggcgtcat ttcccatcct ttcggtagtg tgattcgcag tctgcttgtc gctatcttcg
    11581 agttaggtgt ggaggaaata atggtgattg cccattctga ttgtggagcc tgccatatgc
    11641 acagtgaaga aatgcttgag aagatgaagg cacggggtat taatgccgat tatattcata
    11701 tgatgagttt ttgtggagtc gattttcatt cttggctaga tggctttgaa gatacggaga
    11761 agtcggtaag gggaacggtc gattttatag ttcatcatcc tttgattccg tcggacgtga
    11821 aagtgcacgg gtttatcata gactccacta ctggagaact gacgcgaatt gtataggaaa
    11881 tcgccctttc tgcctatcag gaactgcata aaacatggtg tcactatcgc aacaggatag
    11941 tgtcactatc actgtctcat ggtgtcacta tgtcattggg ataccgacac tatcccaaat
    12001 gaaaaaaata aggcagcttt ttatcggctg cctttatctt tctgcggtta tatactttct
    12061 ttgactcatg cactcgtttg taacaaacgg ggtgtccgtg ctctttgatt tctgcctcac
    12121 ggctggcttt acgattcgct ttgatgtaat cgtcttgtgt aattcgtttt ttcataatga
    12181 atatatttct cagtgcaaag atacaatttc atttcttatt acgatcggtt tgcgctatct
    12241 ttgcatacat aaatcaaatg aaaacggaaa taatatggaa aatttcagtg aactgataaa
    12301 gaatcgccgc agtatgcgca aatttacgga tgaggagtta acacaggatg aggttgtggc
    12361 actgatgaaa gctgccttga tgtctcccag ttccaaacgt agtaatagct ggcagtttgt
    12421 ggtagtcgat gataaagaaa agttgaaaga actgtctcac tgcaaagagc aggcttcctc
    12481 gttcattgcg gatgctgctt tggcgattgt tgtgatggct gatccgttgg caagcgatgt
    12541 gtggattgaa gatgcttcta ttgcttccat catgatacag ttgcaggcgg aagatttggg
    12601 gctgggaagc tgttgggtac aggttcgcga acgtttcact gcaaccggaa tgccgtctga
    12661 cgagtttgtt catggaattt tggatattcc tttgcaactg cagattcttt ccgtgattgc
    12721 catcggacat aagggaatgg aacgtaagcc tttcaacgaa gaacacctcc agtgggagaa
    12781 aattcatatt aataagttcg gaggaaaata acgatgggag ctgtcaaagc aaataataat
    12841 aaagatactt ataaggctac tgccgtcgct tttattgtta tcggaactct tttcctgata
    12901 aataaactgc tcccctttgc ttctataggt ttgccttggg tgatgaataa ggacaatttg
    12961 ttgttgtatg cctctatcag ttttcttatt ttcaagcgtg acaagtcggt cggctttgtg
    13021 ctgttgggac tgtggctggt aatgaatatc ggtctggtaa tgtcattgct cggttccttg
    13081 tccggttatc tgttgccatt ggcactgttg atcatcggaa ttattttatt ttgggtttca
    13141 aaacgttaaa gaaacaatga aaagaagtat tgaagatacg cccgttgtgt ttctcggtgc
    13201 cggaaatctg gcaactaatc tggcgaaagc gctttaccgg aaaggattcc gtatcatgca
    13261 ggtgtacagc cgaacggaag aatcggctcg tacgttagcc aatgaagtgg aagcggaata
    13321 tatcactgat ttaaaagacg tatcgaatga agcgagatta tatattattt cattgaaaga
    13381 tgccgctttc gtcgaactgt tgcctcagat cactgatggg aagcagcatg cgctgttggt
    13441 gcatacggca ggcagcatcc cgatgaatat ttgggaaggt catgcggaac gctacggagt
    13501 attttatccg atgcagacgt tcagcaaaca acgtgaagtt gattttcggg aagtaccttt
    13561 ctttattgaa gcaaaaagac cggaagatac cgagctgctg aaagcggttg ccggtacact
    13621 ctctgataag gtgtacgaag ccgattcgga gcaacgcagg agtcttcatc tggcagctgt
    13681 ctttacctgt aactttacca accatatgta tgctcttgcc gccgaattgc tggaaaaata
    13741 tcatttgcca tttgatgtta tgcttcccct gattgacgaa acggcacgca aagtgcatga
    13801 acttgctcct cgtgatgcgc agaccggacc ggctgtacgc tatgacgaga atgtgatgaa
    13861 taagcatctt tctatgctgg cagacagtca ggcattgcag gaaatttata aattaatgag
    13921 taaaagtatc catgagcacc atcaattatg atctatcccg catcaaagca ctggcttttg
    13981 atgttgacgg agtattgagt tcgacaacag tcccgttgca tccttccgga gaaccgatgc
    14041 gtacggtgaa tattaaagac ggttatgcca ttcagttggc agtaaagaaa ggactccata
    14101 ttgctatcat taccggtgga cggacagaag cggtacgtat ccggtttgca gcattgggtg
    14161 tgaaggatct gtatatgggg tctgcagtga aaattcatga ttaccgtaat ttccgcgata
    14221 aatacggtct gtctgatgac gaaattctgt atatgggcga tgatgtgcct gatatagaag
    14281 tgatgcgtga gtgcgggttg ccttgttgtc ccaaagatgc tgttccggaa gttaagtcgg
    14341 tcgcgaagta tatatcttat gccgatggcg gtcgtggctg tggacgtgat gtggtggaac
    14401 aagtattgaa agctcatggc aagtggatgg cggaagatgc tttcggctgg tgagttgtaa
    14461 atcacttaat aataaataaa attatgcttg gaaatttaga taaatatcag attatattag
    14521 cctccaattc tccccgccgg aaagaactga tgtcaggttt gggag
//
