LOCUS       c00106_gnlPro..        13618 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|DDGAJHJB_106.
ACCESSION   c00106_gnlPro..
VERSION     c00106_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-05 02:29:36
            Original ID  :: gnl|Prokka|DDGAJHJB_106
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13618
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13618
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[7626:13607]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      7627..13607
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..13618
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..13618
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             complement(264..1607)
                     /locus_tag="ctg106_1"
                     /transl_table=11
                     /translation="MKKEYLIYKLSEEMKEATRIDNELFPKFDVKRGLRNEDGTGVLVG
                     LTKIGNVVGYERIPGGGLKPIPGKLFYRGYDVEDISHAIIKEKRFGFEEVAYLLLSGRL
                     PDKEELASFRELINDNMALEQKTKMNIIELEGNNIMNILSRSVLEMYRFDPDADDTSRD
                     NLMRQSIDLISKFPTIIAYAYNMLRHATFGRSLHIRHPQEKLSIAENFLYMLKKDYTEL
                     DARTLDLLLILQAEHGGGNNSTFTVRVTSSTGTDTYSAIAAGIGSLKGPLHGGANIQVA
                     DMFHHLQENIKDWKSVDEIDTYFTRMLNKEVYNKTGLIYGIGHAVYTISDPRALLLKEL
                     ARDLAREKGKEEEFAFLELLEERAIATFGRVKNNGKTVSSNIDFYSGFVYEMIGLPQEI
                     FTPLFAMARIVGWCAHRNEELNFEGKRIIRPAYKNVLDDLAYIPIKKR"
     CDS             complement(1633..2808)
                     /locus_tag="ctg106_2"
                     /transl_table=11
                     /translation="MQKDGTLSVPDVPVVPYITGDGVGAEVTPSMQSVVNAAVQKAYGG
                     KRRIEWKEVLAGERAFNETGSWLPDETMKAFQEYLIGIKGPLTTPVGGGIRSLNVALRQ
                     TLDLYVCLRPVRWYQGVHSPVKAPEKVNMCVFRENTEDIYAGIEWEAGTPEAEKFYQFL
                     KNEMGVTKVRFPETSSFGVKPVSREGTERLVRAACQYALDHHLPSVTLVHKGNIMKFTE
                     GGFKKWGYELAQREFGDALADGRLVIKDCIADAFLQNTLLIPEEYSVIATLNLNGDYVS
                     DQLAAMVGGIGIAPGANINYKTGHAIFEATHGTAPNIAGKDVVNPCSIILSAVMMLEYL
                     GWKEAAALIEKALEQSFLDARATHDLARFMPGGTSLSTTAFTREIVERIEK"
     CDS             complement(2838..5081)
                     /locus_tag="ctg106_3"
                     /transl_table=11
                     /translation="MVYDLTMLEAFYSAYKGKVEHVRAVLKRPLTLAEKILYAHLFNEG
                     DLKNYKRGEDYVNFRPDRVAMQDATAQMALLQFMNAGKEKVAVPSTVHCDHLIQAYKGA
                     KEDIATATKTNEEVYDFLRDVSSRYGIGFWKPGAGIIHQVVLENYAFPGGMMVGTDSHT
                     PNAGGLGMVAIGVGGADAVDVMTGMEWELKMPRIIGVRLTGKLSGWTSPKDVILKLAGI
                     LTVKGGTNSIIEYFGPGTASLSATGKATICNMGAEVGATTSLFPFDGRMATYLRATGRD
                     RIVELAEAVDCELRADQQVTDEPEKYYDRVIDIDLSTLEPYINGPFTPDAATPISEFAE
                     KVLLNGYPRKMEVGLIGSCTNSSYQDLSRAASLARQVKEKNLSVASPLIINPGSEQIRA
                     TAERDGMMDDFMQIGAVIMANACGPCIGQWKRHTDDPTRKNSIVTSFNRNFAKRADGNP
                     NTYAFVASPELTMALTIAGDLCFNPLKDRLMNHDGEKVKLAEPVGDELPLRGFTSGNEG
                     YITPGGTKTAINVNPASQRLQLLTPFPAWDGQDILNMPLLIKAQGKCTTDHISMAGPWL
                     RFRGHLENISDNMLMGAVNAFNGETNNVWNRSTNTYGTVSGTAKMYKSEGIPSIVVAEE
                     NYGEGSSREHAAMEPRFLNVRVILAKSFARIHETNLKKQGMLALTFADKADYDKIQEHD
                     LLSVIGLPDFAPGRNLTVVLHHEDGTKESFEAQHTYNEQQIAWFRAGSALNAR"
     CDS             5148..7094
                     /locus_tag="ctg106_4"
                     /transl_table=11
                     /translation="MKYIFVSGRRFITFASIMNNHPKSPIIDLQQQQLLLRMEYEHEKE
                     EFKRQTETMGVARKVKRGLCWYPASPGRSYYNSLNQLVIDITRTENKEIEHSFEFGRPV
                     CFFRQSFDGKVNYMNFIATVSYADDERMVVVLPSAGALLELQTEEVLGVQLYFDETSYR
                     AMFEALEDTIRAKGNRLAELRDTLLGTQKPGFRELYPVRFPWLNSTQETAVNKVLCTRD
                     VAIVHGPPGTGKTTTLVEAIYETLHREPQVLVCAQSNTAVDWICEKLVDRGVPVLRIGN
                     PTRVNDKMLSFTYERRFENHSAYPELWGIRKSIREMGSRMRRGSYSEREGMRSRMSRLR
                     DRATELEILINADLFDSARVIASTLVSSNHRLLNGRRFPTLFIDEAAQALEAACWIAIR
                     KADRVILAGDHCQLPPTIKCIEAARGGLDHTLMEKVVQQKPSAVSLLKVQYRMHEAIMR
                     FPSEWFYNGELEAAPEVRNRGILDFDTPMNWIDTSEMDFHEEFVGESFGRINKQEANLL
                     LQELEAYISRIGKARILDESIDFGLISPYKAQVQYLRSKIRGSSFLRPFRSLITVNTVD
                     GFQGQERDVVFISLVRANEDGQIGFLNDLRRMNVAITRARMKLVILGDATTLTKHAFYR
                     KLIQYIRQEAVSS"
     CDS             complement(7627..8706)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: IlvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg106_5"
                     /sec_met_domain="IlvN (E-value: 3.2e-47, bitscore: 149.4,
                     seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="IlvC (E-value: 1.7e-40, bitscore: 127.9,
                     seeds: 295, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAQVIKTKKQKKMAQLNFGGTVENVVIRDEFPLEKAREVLKNETI
                     AVIGYGVQGPGQALNLRDNGFNVIVGQRQGKTYDKAVADGWVPGETLFGIEEACEKGTI
                     IMCLLSDAAVMSVWPTIKPYLTAGKALYFSHGFAITWSDRTGVVPPADIDVIMVAPKGS
                     GTSLRTMFLEGRGLNSSYAIYQDATGNAMDRTIALGIGIGSGYLFETTFIREATSDLTG
                     ERGSLMGAIQGLLLAQYEVLRENGHTPSEAFNETVEELTQSLMPLFAKNGMDWMYANCS
                     TTAQRGALDWMGPFHDAIKPVVEKLYHSVKTGNEAQISIDSNSKPDYREKLEEELKALR
                     ESEMWQTAVTVRKLRPENN"
     CDS             complement(8735..9478)
                     /locus_tag="ctg106_6"
                     /transl_table=11
                     /translation="MSEENKIGTYQFVAEPFHVDFNGRLTMGVLGNHLLNCAGFHASDR
                     GFGIATLNEDNYTWVLSRLAIELDEMPYQYEKFSVQTWVENVYRLFTDRNFAVIDKEGK
                     KIGYARSVWAMINLNTRKPADLLALHGGSIVDYICDEPCPIEKPSRIKVTSNQPVATLT
                     AKYSDIDINGHVNSIRYIEHILDLFPIELYQTKRIRRFEMAYVAESYFGDELSFFCDEV
                     SENEFHVEVKKNGSEVVCRSKVIFE"
     CDS             complement(9487..10041)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg106_7"
                     /sec_met_domain="ALS_ss_C (E-value: 4.8e-20, bitscore:
                     61.0, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDKTLYTIIVHSENIAGLLNQVTAVFTRRQINIESLNVSASSIK
                     GVHKYTITAWTDKDTIEKVVKQIEKKIDVIQAHYFTEDEIYFHEIALYKVSTPAFQETP
                     EASKVIRRYNARIVEVNPVFSIVEKNGMSEEITSLYEELRALKCVLQFVRSGRVAITTS
                     CFERVNEFLDGQEAKYKQSKK"
     CDS             complement(10060..11757)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg106_8"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.4e-47, bitscore:
                     150.6, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKDLITGAEAMMRSLEHQGVTTIFGYPGGSIMPTFDALYDHQNT
                     LNHILVRHEQGAAHAAQGYARVSGKVGVCLVTSGPGATNTITGIADAMIDSTPIVVIAG
                     QVGTGFLGTDAFQEVDLVGITQPIAKWSYQIRRAEDVAWAIARAFYIASSGRPGPVVLD
                     FAKNAQVEKTKYEPTKQEFIRSYVPVPDTDEESVKAAAELINNAERPLVLVGQGVELGS
                     AQEELRTFIEKADMPAGCTLLGLSALPTDHPLNKGMLGMHGNLGPNINTNKCDVLIAVG
                     MRFDDRVTGNLATYAKQAKVIHFDIDPAEVNKNVKVDIAVLGDCKKTLAAVTGLLKKNR
                     HTEWVDSFKEYEAVEEEKVIRPELHPATDSLSMGEVVRAVSEATRHEAILVTDVGQNQM
                     ISARYFKYTKERSIVTSGGLGTMGFGLPAAIGATFGRPDRMVCVFMGDGGLQMNIQELG
                     TIMEQKAPVKIICLNNNYLGNVRQWQAMFFNRRYSFTPMLNPDYMKIASAYDIPSKRVF
                     SREELKAAIDEMLSTDGPFLLEACVVEEGNVLPMTPPGGSVNQMLLEC"
     CDS             complement(11805..13607)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ILVD_EDD"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg106_9"
                     /sec_met_domain="ILVD_EDD (E-value: 3.3e-218, bitscore:
                     714.6, seeds: 918, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKQLRSSFSTQGRRMAGARALWAANGMKKNQMGKPIIAIVNSFT
                     QFVPGHVHLHEIGQLVKAEIEKLGCFAAEFNTIAIDDGIAMGHDGMLYSLPSRDIIADS
                     VEYMVNAHKADAMVCISNCDKITPGMLMAAMRLNIPTVFVSGGPMEAGEWNGQHLDLID
                     AMIKSADDSVSDQEVANIEQNACPTCGCCSGMFTANSMNCLNEAIGLALPGNGTIVATH
                     ENRTKLFEDAAKLIVENAMKYYEEGDESVLPRSIATRQAFLNAMTLDIAMGGSTNTVLH
                     LLAVAHEAGVDFKMDDIDMLSRKTPCLCKVAPNTQKYHIQDVNRAGGIIAILAELAKGG
                     LIDTSVLRVDGMSLAEAIDQYSITSPNVTEKAMSKYSSAAGNRFNLVLGSQGAYYQELD
                     KDRANGCIRDLEHAYSKDGGLAVLKGNIAQDGCVVKTAGVDESIWKFTGPAKVFDSQEA
                     ACEGILGGRVVSGDVVVITHEGPKGGPGMQEMLYPTSYIKSRHLGKECALITDGRFSGG
                     TSGLSIGHVSPEAAAGGNIGKIVDGDIIEIDIPARTINVRLTDEELAARPMTPVTRDRY
                     VPKSLKAYASMVSSADKGAVRLID"
ORIGIN
        1 cgttaaaagg gcgtttctac ctgccaggct gtgccctttc taccaacgat aaatgcctta
       61 gcctccatcg gatgaaaaat acagcaaccg caaagtgtta aatgttaaat gaacatcgga
      121 tgttcttcct gaaacaagtc accccagacg tacaaccggg tactaccaag atgtacaact
      181 ggggattacc aagacgtaca tgcagggatt accgagatgt acgtctgagg ttagttatta
      241 ttgcataaaa ggatttgttc ttatcagcgt ttcttgatgg ggatataagc cagatcatca
      301 agaacatttt tataagccgg acggataatg cgtttgcctt cgaagttcag ttcctcattg
      361 cggtgcgcac accagccgac aatacgagcc atggcaaaca gcggagtgaa aatctcctgc
      421 ggcaaaccaa tcatctcata tacgaagccc gaatagaagt cgatattgct ggaaaccgtc
      481 tttccgttgt tcttcacacg tccgaaagta gcgatggcac gctcttcaag cagttcgagg
      541 aaagcgaact cctcttcttt tcctttctca cgggcaaggt cgcgagccag ttctttcagc
      601 aacagcgcac gaggatcgga aatcgtgtaa acagcatgac cgataccgta aatcaatccg
      661 gtcttattat acacttcctt attcagcatt cgtgtgaaat aggtatctat ctcgtccacg
      721 ctcttccagt ccttgatatt ctcctgcaag tgatggaaca tatcggccac ctggatattc
      781 gcgcctccgt gaagcgggcc tttcaacgaa ccgatacctg cggcgatggc cgaatatgta
      841 tctgttccgg tggaagaagt cacacgaacc gtgaaagtcg agttgttacc accgccgtgt
      901 tctgcctgca aaatcaatag caagtcgagc gtacgggcat ccagttccgt ataatctttt
      961 ttgagcatat agaggaaatt ctcggcaata gagagtttct cctgcggatg acggatgtgc
     1021 agggaacgac cgaatgtagc atggcggagc atattataag catacgcaat gatggtcggg
     1081 aacttggaga taagatcgat actctggcgc atcagattat cgcgggaagt atcgtcggca
     1141 tcgggatcga aacgatacat ttcgagtacg ctgcgcgaaa gaatattcat gatattattt
     1201 ccctccagct cgataatatt cattttcgtc ttctgttcga gcgccatatt gtcattgatc
     1261 agttcgcgga aagaagccag ttcttccttg tccggcaggc gaccggaaag cagcagataa
     1321 gccacttctt cgaagccgaa acgtttttcc ttgatgatgg cgtgggaaat gtcttccaca
     1381 tcgtagcccc gatagaacaa ttttcccgga attggcttca gaccgccgcc ggggatacgt
     1441 tcgtaaccta ccacattacc aatctttgtc agacctacca atacaccggt gccgtcttca
     1501 ttacgcagtc cacgcttcac gtcaaacttg gggaacaatt cattgtcaat ccgggttgcc
     1561 tctttcatct cctcggagag cttgtaaatc aaatactctt tcttcataat acttcgtttt
     1621 taatcgttac atttactttt cgattctttc cacaatttcg cgtgtgaaag cggtggtaga
     1681 cagggatgta cctcccggca taaagcgagc cagatcgtgc gtggcacggg catcgaggaa
     1741 actctgttcc aacgcctttt cgataagcgc ggccgcttct ttccatccca gatattcaag
     1801 catcatcacc gccgaaagaa tgatagaaca aggattcacg acatcctttc cggcaatgtt
     1861 gggggcggtt ccatgagtcg cttcaaaaat ggcgtgcccc gtcttgtagt taatatttgc
     1921 tcccggagca atgccgatgc cgcctaccat tgccgccaac tggtcggaaa cgtagtctcc
     1981 gttcaggttc agcgtggcaa tcacggaata ttcttcggga atcagtaatg tattttgcag
     2041 gaaagcatcg gcgatgcagt cctttatcac caaccggccg tctgccaagg cgtcgccgaa
     2101 ctcacgttgc gccagctcat agccccattt cttgaagcct ccttcggtga acttcataat
     2161 gtttcctttg tgcaccagtg tcacggaagg cagatgatgg tcgagcgcat actggcaggc
     2221 agcccgcaca agacgttccg tgccctcacg ggaaacaggt ttcactccaa aagaagaggt
     2281 ctcggggaag cggactttcg tcactcccat ctcgtttttc aggaattgat agaacttttc
     2341 ggcttcggga gtacctgcct cccactcgat tcctgcatat atatcctccg tattttcacg
     2401 gaacacgcac atgttcactt tttccggtgc tttcaccgga gaatgaacgc cttgatacca
     2461 acggaccgga cgcagacaaa catacaaatc cagagtttgg cgcaaagcca cgttcaaaga
     2521 acggattcca ccgccgacag gggtcgtcag cggccccttg atgccgatca gatattcttg
     2581 gaaagccttc atcgtttcat ccggcaacca cgaacctgtc tcgttgaaag cgcgttcgcc
     2641 cgccagcact tctttccatt caatccgacg tttgccgccg tatgctttct gaacagccgc
     2701 gttcacaacg gactgcatcg acggagtcac ttccgctcct actccgtctc cggtaatata
     2761 aggtacgaca ggcacatcgg gcaccgatag cgtaccatct ttttgcatgg ttattttgtt
     2821 catttctatc attttaatta tctggcattc aaggcagagc cggcacggaa ccaggcaatc
     2881 tgctgttcgt tgtatgtatg ttgcgcttca aaactctctt tcgttccgtc ttcgtgatgg
     2941 agaacgacgg tcagattccg tcccggagca aagtccggca agccgatgac tgaaaggagg
     3001 tcgtgctcct gtatcttgtc ataatccgct ttgtctgcaa aggtaagggc aagcatgccc
     3061 tgctttttca gattcgtttc gtggatacgg gcgaagctct tggcgagaat cacacgcaca
     3121 ttcaggaaac ggggttccat tgccgcgtgc tcgcgactgg agccttctcc atagttttct
     3181 tcggccacga caatagaggg gattccttcg gatttataca ttttggctgt gcccgaaacg
     3241 gttccgtagg tgtttgtcga acggttccac acgttgttcg tttcgccatt gaacgcattc
     3301 acggctccca ttagcatatt atccgaaata ttctccaaat gtccgcggaa acgcagccac
     3361 ggtcccgcca tcgaaatatg gtcggtagta catttgccct gcgccttaat cagcaggggc
     3421 atattgagta tatcttgtcc gtcccaagcg gggaaaggag tcagcagttg caggcgttga
     3481 gaagccgggt tgacgttgat cgctgttttc gtcccgccgg gggtgatata gccttcattg
     3541 ccggaggtga aacctctcaa ggggagttca tctcctacgg gttcggccag tttcactttc
     3601 tcgccgtcat ggttcatcag tctgtctttc agcggattga agcaaagatc accggcaatg
     3661 gtcagtgcca tcgtcagttc gggagaagca acaaaggcgt atgtgttcgg attgccgtcc
     3721 gcacgtttgg caaagttacg gttgaaggat gtgacgatcg agttcttccg tgtcgggtcg
     3781 tccgtatgac gtttccactg accgatgcaa ggaccgcagg catttgccat gatcacggcg
     3841 ccgatctgca tgaagtcatc catcattccg tctctttcgg cagtagcgcg gatttgctcg
     3901 gaacccggat tgataatcag cggggaagcc acactcagat tcttttcctt cacctgcctt
     3961 gcaagggatg cggcacggct gagatcttgg taagaagagt tggtacacga accgatcagt
     4021 ccgacttcca tcttacgcgg atagccgttc agtaatactt tttctgcaaa ttcagagata
     4081 ggggtagcgg catccggtgt gaaagggccg ttgatataag gttcgagcgt ggacaagtca
     4141 atgtcgatga cacggtcgta gtacttttcc ggttcgtccg tcacctgttg gtccgcacgg
     4201 agctcacagt ccacggcttc cgccagttcc acgatgcgat ccctgccggt ggctctcaga
     4261 taagtagcca tgcgcccgtc gaacgggaaa agcgaagtgg tagctcctac ttccgcaccc
     4321 atattgcaaa tggtcgcttt gccggtagcc gacagggaag ctgttcccgg tccgaaatat
     4381 tcgatgatgg agttcgttcc tccttttacg gtcagaatcc cagcaagttt caggatcaca
     4441 tctttcgggg aagtccagcc gctcagtttt ccggtcaggc ggacaccgat aatccttggc
     4501 attttcagtt cccattccat acccgtcatc acgtctacgg catccgcacc gccgacgccg
     4561 atggccacca tgcccagtcc tccggcattc ggagtgtgag agtcggttcc taccatcatc
     4621 ccgccgggga aagcgtaatt ttcgagcact acctggtgaa tgattccggc gcccggcttc
     4681 cagaagccga tgccgtaacg agaggataca tcgcgcaaaa agtcgtaaac ttcttcgttt
     4741 gttttggttg ccgtagcaat gtcctccttt gctcctttgt acgcttgtat caagtggtca
     4801 cagtgcacgg tggagggaac agccactttt tcttttcctg cattcatgaa ttgaagcaat
     4861 gccatctggg cagtcgcgtc ctgcatagcg acgcggtcgg gacggaaatt tacgtagtct
     4921 tcaccccgct tgtagttttt cagatcgccc tcattgaaca gatgggcata cagaatcttc
     4981 tcggctaacg tcaatgggcg tttcaaaaca gcccgcacgt gttccacttt tcctttataa
     5041 gcagaataaa aagcctctaa catagtcaaa tcatacacca tattgctttt atttttttta
     5101 gtctatctat aaaaataacg aacggcgttc gaggaatgtt taacaaaatg aaatatattt
     5161 tcgtctcagg aagaagattt attacctttg cgtctattat gaataatcat ccgaaaagtc
     5221 caatcatcga ccttcagcaa cagcaactcc tgctacgcat ggagtatgaa cacgaaaagg
     5281 aggaattcaa gcggcagact gaaacaatgg gtgtcgcccg caaagtgaaa cgtggtctgt
     5341 gctggtatcc cgcctctccc ggtcgaagtt actataattc tctaaatcaa cttgtaatag
     5401 atattacacg caccgaaaat aaagaaatcg agcattcctt cgaattcggt cgtcccgtct
     5461 gctttttccg gcagtcattt gacggaaaag tgaattacat gaatttcatt gcaacggtga
     5521 gttatgcgga cgacgaacgg atggtggtcg tgcttcccag tgcgggcgcc ttgctggaac
     5581 tgcaaacgga agaggtgctg ggtgtacaac tttatttcga tgaaacgtcc tatcgtgcca
     5641 tgttcgaagc gctggaagac acaatccgcg ctaagggcaa ccgccttgcc gaactccggg
     5701 acaccttgct gggaacacaa aagccgggat tccgcgaatt atatcccgtc cgtttcccgt
     5761 ggctgaacag cacgcaggaa acagccgtaa acaaagtgtt atgcacacgc gatgtcgcca
     5821 tcgttcacgg ccctccggga accggaaaga ctaccacgct cgtggaagcc atttacgaaa
     5881 cgcttcaccg cgaaccgcag gtgctggtct gcgcccaaag taatacggct gtggactgga
     5941 tttgcgagaa actggtagac cggggtgtgc ctgtcctccg cattggtaac cctacacgtg
     6001 ttaatgacaa aatgctttct ttcacttacg aacgccgctt tgagaatcat tcggcctacc
     6061 ccgaactttg gggaatccga aaatcgatcc gtgaaatggg cagccggatg cgtcggggaa
     6121 gttactccga aagggaagga atgcgcagcc ggatgagccg cctccgcgac cgtgccaccg
     6181 aactggaaat cctgatcaac gccgatcttt tcgacagtgc ccgtgtgatt gcttccacgc
     6241 tggtcagcag caatcaccgt ttgctcaacg gacggcgttt ccccacctta tttatcgatg
     6301 aagccgccca ggcactcgaa gccgcctgtt ggatcgccat ccgaaaggcc gaccgtgtga
     6361 ttcttgccgg cgaccattgc cagctccctc ctacaatcaa atgtatcgaa gccgcccgtg
     6421 gcggactgga ccacactcta atggaaaagg tcgtgcagca aaaaccttct gccgtctcgc
     6481 tgctcaaagt gcaataccgg atgcacgaag caatcatgcg ctttccctcc gaatggttct
     6541 acaacggaga actggaagcc gcaccggaag tgcgcaaccg gggtatcctt gacttcgaca
     6601 ctcccatgaa ctggatagat acctcggaaa tggacttcca cgaagagttt gtaggcgaga
     6661 gcttcgggcg catcaacaag caggaagcca acttgttact gcaagaactg gaagcctata
     6721 tcagccggat cggcaaagca cgcatcctgg acgagagcat cgactttggt ctgatttcgc
     6781 cctacaaggc gcaagtgcaa tacctgagaa gtaaaatcag aggaagcagt tttctccgcc
     6841 ctttccgcag cctcatcacg gtcaacacgg tagacggctt tcagggacag gaacgggatg
     6901 tcgtctttat cagcctcgtc cgggcgaacg aggacggaca gatcggtttt ctgaatgatt
     6961 taagacgaat gaacgtagcc attacccgcg cccggatgaa acttgtgatt ttgggagatg
     7021 caaccactct taccaagcat gcgttctacc ggaaactgat acagtatatc cggcaggaag
     7081 cggtatcctc ctgaatcatc gggataaaaa aagaagcccc ctttctcacg aaagaggact
     7141 cccatttaca aacaaaacaa acaatgttat tttcccacta aattctgttc caaaagctct
     7201 gtcttaaatt caatttaacg catacttttt cctgctacag aataaaattc tgcatcatat
     7261 caacgaatca ctaatggaac acgaaatata aaaaggactt gaaatggtat tacagctacc
     7321 attcggtaga gaataactta aatatctttt aatgtaacat tctgatatac tatttattaa
     7381 agaagaaatc atcttcatac gtatcgatct tctgtaagta aaaagtttct tcattgccta
     7441 ttctgtttta tttgttgccg taaaggtaat cataaatgct ctttttcacc tatattatca
     7501 gtatctttta atcttttttt ctactttcat cctttttcta ttactcaaaa gaccggtatc
     7561 tacatagaaa aagcgggaaa atacgctttt cccgcctttt gaaaaactta tatagtataa
     7621 gtctgattaa ttattttccg gacgaagttt acgaactgtc acggcagtct gccacatttc
     7681 gctttcgcgc aatgctttca gttcttcttc cagtttctca cgataatccg gtttggagtt
     7741 agagtcgatt gaaatctgtg cttcgttacc agtcttcaca ctgtgataca acttttcaac
     7801 taccggtttg atagcatcgt ggaaggggcc catccagtcg agagcaccac gttgagctgt
     7861 agtagagcag ttagcataca tccagtccat accgttcttt gcaaacaacg gcatcaatga
     7921 ctgagtcagc tcttctacag tttcgttgaa tgcttcggaa ggagtgtgac cgttttcacg
     7981 taacacttcg tattgtgcca gcaacagacc ctggatagct cccatcaatg aaccacgttc
     8041 gcctgtcagg tcggaagtag cttcgcggat gaaagttgtt tcgaacaaat aacctgaacc
     8101 gataccgata cccaatgcga ttgttctgtc catagcgttg cctgttgcat cctgatagat
     8161 agcgtaagaa gagttcaagc cgcgaccttc aaggaacata gtacgcaagg atgtacccga
     8221 acctttagga gcaaccatga ttacgtcgat atctgcagga ggaactacac ctgtgcgatc
     8281 actccatgta atagcaaaac catgagagaa ataaagagct tttcctgcag tcaggtaagg
     8341 cttgatagta ggccatacag acattaccgc tgcatcagac aacaggcaca taatgatcgt
     8401 acctttttcg caagcttctt caataccgaa caaagtttca cccggaaccc atccgtcagc
     8461 taccgctttg tcatatgtct ttccctggcg ttgaccaacg attacattga aaccgttatc
     8521 acgaaggttc agagcctgtc caggaccttg tacgccataa ccgattacag cgattgtttc
     8581 atttttcaat acttcacgag ctttttccaa tggaaattca tcacggataa ctacattttc
     8641 tacagttccg ccaaaattca actgtgccat ttttttttgt ttttttgttt tgatgacttg
     8701 cgccatctgt tattaattga ttttatactc tatattattc aaatatcact ttggaacggc
     8761 atactacctc gctgccgttt ttcttcacct ctacatgaaa ctcgttttca ctcacctcat
     8821 cacagaagaa agagagttca tctccgaaat aactttcagc cacatacgcc atttcaaacc
     8881 ggcggatacg tttcgtctga tacagttcta tcggaaacaa gtcaagtatg tgctcgatat
     8941 aacgaatact gtttacgtgt ccgttaatat cgatatcact gtattttgcc gtcagcgtcg
     9001 caacaggctg attgcttgtc accttgatac gcgaaggctt ttctatcggg cagggttcat
     9061 cgcatatata atcgacgatg cttcctccat gcaatgccaa cagatcggca ggcttacggg
     9121 tattcagatt gatcatcgcc catacggaac gggcatagcc gatcttcttt ccttccttgt
     9181 caatgacggc aaagttacgg tcggtaaaca gacgatagac attctctacc catgtctgaa
     9241 ccgagaactt ctcgtattgg taaggcatct catccagctc gatagccagg cgggaaagca
     9301 cccatgtgta attgtcctcg ttcagcgtag caataccaaa tccacggtcg ctggcatgaa
     9361 aacctgcgca attcagcaga tgatttccca gcacgcccat tgtcaggcgc ccgttaaaat
     9421 ctacgtggaa cggctctgcc acaaactgat aagtccctat tttattttct tcactcatta
     9481 ctcctgttac tttttacttt gcttatactt cgcctcctgt ccgtccagga actcattcac
     9541 acgttcgaag cagctggtag taatagccac acgacccgaa cggacaaatt gcaacacaca
     9601 tttcaaagcc cgaagttctt cgtaaaggga agtaatctct tcactcatgc cgttcttctc
     9661 gacgatagag aataccggat tcacctctac aatgcgggca ttatatctgc ggatcacttt
     9721 agatgcttcc ggagtctcct gaaaagcagg agtagatacc ttatataagg ctatctcatg
     9781 gaaataaatc tcgtcttccg taaaatagtg cgcctgaatc acatcaatct tcttttcgat
     9841 ctgcttcacc accttttcaa tagtgtcctt atcagtccac gctgtgatcg tatatttatg
     9901 tactccttta atggaagaag cagaaacgtt caaactctcg atgtttattt gccgacgggt
     9961 aaatacagcg gtcacctgat tcagcaatcc ggctatattt tcagaatgaa ctataatcgt
    10021 atataatgtc ttatcactca taactttcta aattaaggat taacattcca gcaacatctg
    10081 attgactgaa ccgcccggag gggtcatcgg caggacattg ccttcttcta ccacacaggc
    10141 ttcgagcagg aacggtccgt ctgtcgagag catttcgtcg atggccgctt tcagttcttc
    10201 ccgtgaaaag acacgtttgg aaggaatatc gtaggcggaa gcgattttca tgtaatccgg
    10261 attcagcatc ggagtaaatg aataacggcg attaaagaac atggcctgcc attggcgcac
    10321 gttgccgaga taattgttgt tcaggcagat aatcttcacc ggagctttct gttccataat
    10381 cgtacccagc tcctgaatgt tcatttgcag tccgccgtca cccataaata cgcataccat
    10441 gcggtcggga cggccgaaag tagctccgat agctgccgga aggccaaaac ccatcgtgcc
    10501 gagtccgccc gaagtaacga tactacgttc cttggtatat ttaaagtagc gggcagagat
    10561 catctgattc tgacctacat ctgtcaccaa tatggcttcg tgacgggtcg cttcgcttac
    10621 cgcacgcacc acttcgccca tactcagtga atccgttgca ggatgaagtt cgggacgaat
    10681 gactttttct tcctctaccg cttcatattc cttgaaacta tcgacccact cagtgtgccg
    10741 gttctttttc agcagtccgg tcacagcagc cagcgtcttt ttgcagtcgc ccaaaacggc
    10801 aatgtctacc tttacattct tatttacttc cgccggatca atatcaaaat ggatcacttt
    10861 cgcttgtttg gcgtaagtag ccagattacc ggtcacacgg tcgtcgaaac gcataccgac
    10921 agcaatcagt acatcacatt tgttagtatt gatattcggt cccagatttc cgtgcatacc
    10981 cagcattcct ttattcaacg gatggtcggt aggcaatgcg gaaagtccga gcaaggtaca
    11041 acctgcgggc atatccgcct tttcgataaa ggtacgcagt tcttcctgag cgcttcccag
    11101 ttccactccc tgtcctacca agacaagcgg gcgttcggcg ttgttgatca gttcggcggc
    11161 agcctttacc gattcttcgt ctgtatcggg aaccggaaca tagctgcgga taaactcctg
    11221 ctttgtcggc tcgtatttcg ttttttcaac ctgcgcattc ttggcaaagt cgagtaccac
    11281 cggaccggga cgaccactac tggcaatgta gaaagcacgt gctattgccc aggctacgtc
    11341 ttcggcacgg cgaatctgat agctccattt agcgattggc tgagtgatac ctacgagatc
    11401 gacttcctga aaagcgtctg ttccaagaaa gcctgttccc acctgtcctg caatgacaac
    11461 gataggcgta ctgtctatca ttgcatctgc aatacctgtg atcgtattgg ttgctccagg
    11521 gccgcttgtc accaagcaaa caccgacttt acccgataca cgggcgtagc cttgtgccgc
    11581 atgggcagct ccctgttcat ggcgaaccaa gatatggttc aatgtatttt gatggtcgta
    11641 cagggcatcg aacgtaggca tgattgaacc gccgggataa ccgaaaatgg tagtcactcc
    11701 ctgatgttcc agagagcgca tcattgcctc tgcgcctgtt attaagtcct tactcatagt
    11761 tctttaatgg ataatggatg attcataatg gataatgaag tggatcagtc tattaatctc
    11821 actgctccct tatcggcaga gcttaccatg ctggcgtatg ctttcaggct cttcggcacg
    11881 taacggtcac gggtgacggg agtcatcggg cgggcagcca gttcttcatc tgttagtcgc
    11941 acgttaatcg ttcgggcggg aatgtcgatt tcgatgatat ctccatctac tatttttcct
    12001 atattacctc cggcagcggc ttcgggagaa acgtgtccga tactcaatcc ggaagttcca
    12061 ccactgaaac gtccgtcggt aatcaaggca cattctttgc cgaggtgacg ggatttgata
    12121 taagaagtcg ggtaaagcat ttcctgcata ccgggaccgc ccttcggacc ttcgtgcgtg
    12181 atgacgacaa cgtcgccgct gacgactcgg cctccgagga tgccttcaca ggctgcttct
    12241 tgtgagtcga atactttggc aggtccggta aacttccaga tgctttcgtc tacacccgcc
    12301 gtttttacta cgcaaccgtc ctgagcgata tttcctttca gtaccgccaa acctccgtcc
    12361 ttgctatagg cgtgctccag atcacggata catccgttcg cgcgatcttt atctaattcc
    12421 tgataataag ctccctgaga accaagtacg agattgaatc tgtttcctgc cgcacttgaa
    12481 tatttgctca ttgctttttc cgtaacgttc gggctggtaa ttgaatattg atcgatcgct
    12541 tccgccagcg acatgccatc cacacggaga acggaagtat caatcagacc gccttttgcc
    12601 aactctgcca ggatagcaat gatgccaccc gcacggttaa cgtcctgaat atgatatttt
    12661 tgagtattcg gagcgacttt acacaggcag ggtgtcttgc gtgacagcat atcgatgtcg
    12721 tccatcttga aatcgactcc tgcctcatgt gccacggcca acaggtgaag caccgtattg
    12781 gtagaaccgc ccatcgcaat atccagcgtc atggcattga ggaatgcctg acgggtagct
    12841 atgctgcgag gaagtacact ttcgtcacct tcttcataat atttcattgc attttccaca
    12901 atcagtttgg cagcatcttc aaacagtttc gtacgatttt cgtgcgtagc cacgattgtg
    12961 ccgtttcccg gaagagccaa gccgatagct tcattcagac agttcatcga gtttgccgta
    13021 aacattccgg aacaacatcc gcaggtagga caggcattct gttcgatatt cgctacttcc
    13081 tgatcgctta cactgtcgtc cgccgattta atcatggcat cgatcaagtc cagatgctga
    13141 ccgttccact ctccggcttc catcggtccg ccggatacaa atacggtagg gatattcagg
    13201 cgcatggcag ccatcagcat ccctggggta atcttatcgc agttgctgat acataccatt
    13261 gcatccgcct tgtgcgcatt gaccatatat tctacgctgt ccgctatgat atcacgggaa
    13321 ggaagcgagt aaagcattcc gtcatgtccc atagcgatac cgtcatcaat agcaatcgta
    13381 ttaaattccg cagcgaagca tcccagcttc tcaatttccg ccttcaccaa ctgcccgatt
    13441 tcatgcaggt gcacgtgtcc cggaacaaat tgtgtaaacg aattgacgat agcgataatg
    13501 ggttttccca tctgattttt cttcatgccg ttggctgccc ataatgcgcg ggctcccgcc
    13561 atgcgacggc cttgtgtact aaacgaactg cgtaattgct ttttcatttc aatctatc
//
