LOCUS       c00079_gnlPro..        14568 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|MFJLCDGJ_79.
ACCESSION   c00079_gnlPro..
VERSION     c00079_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-07 05:06:35
            Original ID  :: gnl|Prokka|MFJLCDGJ_79
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14568
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14568
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[6:4568]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      7..4568
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..14568
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14568
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             complement(7..1167)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg79_1"
                     /sec_met_domain="OAD_beta (E-value: 2.8e-154, bitscore:
                     503.5, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGDFINFLGNNLADFWTYTGFANATVGHIVMILVGLFFIYLAVAK
                     EFEPMLLIPIGFGILIGNIPFNMDAGLKVGIYEEGSVLNILYQGVTSGWYPPLIFLGIG
                     AMTDFSALISNPKLMLIGAAAQFGIFGAYMIALEMGFDPMQAGAIGIIGGADGPTAIFL
                     SSKLAPNLMGAIAVSAYSYMALVPVIQPPIMRLLTTKHERVIRMKPPRAVSHTEKVIFP
                     IIGLLLTCFLVPSGLPLLGMLFFGNLLKESGVTRRLANTASGPLIDVITILLGLTVGAS
                     TQASEFLTLDSIKIFALGALSFIIATASGVIFVKIFNLFLKKGNKINPLIGNAGVSAVP
                     DSARISQVVGLEYDPTNYLLMHAMGPNVAGVIGSAVAAGILLGFLM"
     CDS             complement(1169..1603)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 66.7; E-value:
                     4e-21)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg79_2"
                     /sec_met_domain="Biotin_lipoyl (E-value: 1.2e-21, bitscore:
                     66.7, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKEYKYKINGNSYKVTIGDIEDNIAHVEVNGTHYKVEMEKQPKTA
                     PKPVVVRPMPNSPAAPTTPVVKPAAPSTGKSGVKSPLPGVILDIKVNVGDTVKRGQTII
                     ILEAMKMENNINADKDGKVTAINVNKGDSVLEGNDLVIIE"
     CDS             complement(1628..2548)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg79_3"
                     /sec_met_domain="OAD_gamma (E-value: 5.3e-15, bitscore:
                     46.2, seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKTKIGIFLSLLLLIGLTSCGEQKSNNKLLLNEVLIDNQNNFQD
                     DYGLHSAWIEIFNKSYGSADLAACLLKVSSQPGDTVTYFIPKGDILTLVKPRQHALFWA
                     DGEPNRGTFHTSFKLNPETANWVGLFDSGRKLLDQVVIPAGTLGPNQSYARISDGAADW
                     EVKGGSKDKYVTPSTNNKTLDSNAKMEKFEEHDSVGIGMSISAMSVVFCGLILLFIAFK
                     VVGKVAVNLSKRNAMKAKGIDKVEAKELSQAPGEVYAAISMALHEMQDEVHDVEETVLT
                     ITRVKRSYSPWSSKIYTLRENPNRK"
     CDS             complement(2580..4133)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Btheta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg79_4"
                     /sec_met_domain="CT_Btheta (E-value: 4e-290, bitscore:
                     952.6, seeds: 72, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNQLEKIKELIERRAVARIGGGEKAIAKQHEKGKYTARERLAML
                     LDEGSFEEMDMFVEHRCTNFGMEKKHYPGDGVVTGCGTIEGRLVYVFAQDFTVSAGSLS
                     ETMSLKICKIMDQAMKMGAPCIGINDSGGARIQEGINALAGYAEIFQRNILASGVIPQI
                     SGIFGPCAGGAVYSPALTDFTLMMEGTSYMFLTGPKVVKTVTGEDVSQENLGGASIHST
                     KSGVTHFTAQTEEEGFELIRKLLSYIPQNNLEEAPYVDCTDPIDRLEDSLNDIIPDSPT
                     KPYDMYEVIGAIVDNGEFLEIQKDYAKNIIIGFARFNGQSVGIVANQPKYLAGVLDSNA
                     SRKGARFVRFCDAFNIPIVSLVDVPGFLPGTGQEYNGVILHGAKLLYAYGEATVPKVTI
                     TLRKSYGGSHIVMSCKQLRGDMNYAWPTAEIAVMGGAGAVEVLYAREAKDQENPAQFLA
                     EKEAEYTKLFANPYNAAKYGYIDDVIEPRNTRFRVIRALQQLQTKKLSNPAKKHGNIPL
                     "
     CDS             complement(4164..4568)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Glyoxalase_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg79_5"
                     /sec_met_domain="Glyoxalase_4 (E-value: 2e-24, bitscore:
                     76.4, seeds: 51, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKISHIEHLGIAVKSIEEALPYYENVLGLKCYNIETVEDQKVRTA
                     FLKVGETKIELLEPTCPESTIAKFIENKGAGVHHVAFAVEDGVANALAEAESKEIRLID
                     KAPRKGAEGLNIAFLHPKSTLGVLTELCEH"
     CDS             complement(4742..5740)
                     /locus_tag="ctg79_6"
                     /transl_table=11
                     /translation="MPLKLTTYYRGKDIPDLPGTNTFHSKELFQIYESTPGYTPLLIVA
                     TEEGRPVARLLAAIRKTKKWLPSSLVKQCVVYGAGEFLDTSLPASKEKEEEIFGEMLEH
                     LTQEASRTCILIEFRNLDNSMFGYRFFRKNDFFPVNWLRVRNSLHSTQKAEDRFSPSRI
                     RQIRKGLKNGAKVVEAHTVEEIKEFSRMLHKVYSSRIRRYFPANDFFRHMNSMLIRGKQ
                     AKIFIVKYKEKIIGGSVCIYSGENAFIWFSGGMRKTYALQSPGILAVWKALEDAHERGF
                     RHMEFMDVGLPFRKHGYRDFVLRFGGKQSSTRRWFRISWPWLNNLLVKFYV"
     CDS             5989..9183
                     /locus_tag="ctg79_7"
                     /transl_table=11
                     /translation="MRENAFVEAWKTQHRRVSMILGLTLLCAPSAISVYAENGVNDITV
                     QAVMQTKTVKGTVLDENGEPLLGVSIVVKGTSTGTITDFDGKFSINLPAGSKELVVSYI
                     GYKEQAIIVSGNAPLNIKMVPDTQALDEVVVIGYGTVKKRDLTGAVASVKSEDITMNPG
                     VNPMDALQGKIAGLDITNSSGQAGSSPTVQLRGTRSLQLDEDGNISSDAFKPTYIIDGM
                     PGDIATLNPNDIESIEVLKDASSTAIYGSSGANGVIIVTTKGSKSGKPVINFNAYAGTT
                     MGARVPKMRTGDSYINYIKDSYKPVGTTNEEEIFGERYDAIKNNQWVNWGDEVLHSGLK
                     QNYSISVAGGTEKTKAYFSLNYTDEKSMYENDDYKVYSTRVRIDQEINKWINAGINVQA
                     SFSNKNSRNAVLERALFATPLGVPYNEDGSITEFPIPGSSSDPNPLADEQDGVYKNNTK
                     AGRAYVDAYLEWKPVKGLSVKSQLGGSYSQSRAGKFMGEGSYNVLKGSTVAYGEATNKT
                     GYNYKWENIVTYHNTFNKAHDLTITGVTSWNYNQSEEYYVYGENPATNDMLWYALQNAD
                     NKKLNSKYLMSKGMGFIGRVNYSYKGKYLFSASSRYEADSRLSKDNRWNLFPAVSVGWR
                     ISDEAFMAGTKSWLDNLKLRVGYGVAGTTAGIAEYSSMASLENVTTSLGGMTVPSAKFT
                     EYITNRNLTWEKTHDLNIGIDASFLNNRIDLTVDLYRTKTTDVILSQALPTSIMGNYTG
                     STTYKMNKNAAETENRGIELALNTRNIVKKDFTWSSTVTFTANKEKIKSLIEGQDMMFN
                     AKKGDMVFKVGEGVGSFYRYKVLGIWQYSEKETAALFGCEPGDIKLDLPSVKKDGNGYY
                     YMNPEGERVDITAENPYGVRADYDRQVIGRNTPDWTLGFKNNFRYKDFDLSVFLYARWG
                     QMMNYGSVIGKYSPNPDYNIPTYFTYYDKTIEADQDVLFYAIDKSKDRSAYEGYDSMYY
                     VDGSFFKLKNVTLGYTLPGKLTKRFGISNLRVYATMTNLFTYSPNKYVKNYDPEMNGSI
                     NFPLSRDCIFGLNLTF"
     CDS             9195..11150
                     /locus_tag="ctg79_8"
                     /transl_table=11
                     /translation="MKKIYSLVLLVAGVFSWGSCSLDEVNPNNSGQFSDGSYTLETYKA
                     FTNSCYTALINNIYQSSDYLVCTEAGTDIWEEPKSGSSYQRYHSYNGMKTDDSYYYKVW
                     QYSYLCINSCNIVIDGAENVTGDENEINECVAQARCLRAYYYMNLVEQFGNVDLQLKAA
                     DSENISFDAHRSTVPEIYAAIIEDLKFAVENLPVSFSDYYSRVTKKSAMGLLARAYING
                     AGYDLKDTDGVSFLEKAYDTATTMINNKAIYEWYMHPAFADVFNENNNRNNEEALFIAA
                     GAERNSDAYTNGNYSQSEMFRHFLPSLGTYTDLGLVDKTSNFVYGRPNSNIFLPSKYLM
                     DCFAADMNDSRFRYSFISAYSSYSIPAWGATYEYGGSACAKEITSTLATKFGIPASNIG
                     KKVYPHFNLESNSTADANYCQLAIWNADGTAKTTQDKTDGNILHPAMPLDPAEAHQYAV
                     YCSLKTLTEEEKAQYPGLVLNVFDLYDENGTARATYDKPSAASALWLSIYPALSKFNMP
                     GNKFVGRDVQRKTVDVMIMRMAEVYLIAAEASVRLNKGDAAKYINVLRTRAGAGTVSES
                     QVDLNYVFDEYARELCGECGRWYLLKRNAAFETRLAAYNKRAAEHFKKEFYLRPIPTKY
                     LDAINNPAEFGQNAGY"
     CDS             11337..11879
                     /locus_tag="ctg79_9"
                     /transl_table=11
                     /translation="MIEEMLAYNREFVKNEGYKEYITNKYPDKKIAILSCMDTRLTALL
                     PAALGIKNGDVKMIKNAGGVISHPFGSVIRSLLVAIFELGVEEIMVIAHSDCGACHMHS
                     EEMLEKMKARGINADYIHMMSFCGVDFHSWLDGFEDTEKSVRGTVDFIVHHPLIPSDVK
                     VHGFIIDSTTGELTRIV"
     CDS             complement(11993..12178)
                     /locus_tag="ctg79_10"
                     /transl_table=11
                     /translation="MKKRITQDDYIKANRKASREAEIKEHGHPVCYKRVHESKKVYNRR
                     KIKAADKKLPYFFHLG"
     CDS             12278..12814
                     /locus_tag="ctg79_11"
                     /transl_table=11
                     /translation="MENFSELIKNRRSMRKFTDEELTQDEVVALMKAALMSPSSKRSNS
                     WQFVVVDDKEKLKELSHCKEQASSFIADAALAIVVMADPLASDVWIEDASIASIMIQLQ
                     AEDLGLGSCWVQVRERFTATGMPSDEFVHGILDIPLQLQILSVIAIGHKGMERKPFNEE
                     HLQWEKIHINKFGGK"
     CDS             12817..13152
                     /locus_tag="ctg79_12"
                     /transl_table=11
                     /translation="MGAVKANNNKDTYKATAVAFIVIGTLFLINKLLPFASIGLPWVMN
                     KDNLLLYASISFLIFKRDKSVGFVLLGLWLVMNIGLVMSLLGSLSGYLLPLALLIIGII
                     LFWVSKR"
     CDS             13160..13954
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Shikimate_DH"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) F420_oxidored"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg79_13"
                     /sec_met_domain="Shikimate_DH (E-value: 8.1e-11, bitscore:
                     32.5, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="F420_oxidored (E-value: 4.5e-13, bitscore:
                     40.1, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRSIEDTPVVFLGAGNLATNLAKALYRKGFRIMQVYSRTEESAR
                     TLANEVEAEYITDLKGVSNEARLYIISLKDAAFVELLPQITDGKQHALLVHTAGSIPMN
                     IWEGHAERYGVFYPMQTFSKQREVDFREVPFFIEAKRPEDAELLKAVAGTLSDKVYEAD
                     SEQRRSLHLAAVFTCNFTNHMYALAAELLEKYHLPFDVMLPLIDETARKVHELAPRDAQ
                     TGPAVRYDENVMNKHLSMLAGSQALQEIYKLMSKSIHEHHQL"
     CDS             13935..14456
                     /locus_tag="ctg79_14"
                     /transl_table=11
                     /translation="MSTINYDLSRIKALAFDVDGVLSSTTVPLHPSGEPMRTVNIKDGY
                     AIQLAVKKGLHIAIITGGRTEAVRIRFAALGVKDLYMGSAVKIHDYRDFRDKYGLSDDE
                     ILYMGDDVPDIEVMRECGLPCCPKDAVPEVKSVAKYISYADGGHGCGRDVVEQVLKAHG
                     KWMAEDAFGW"
ORIGIN
        1 ttgtccctac attaagaatc ctaacaggat accggcagca acagccgaac cgattacacc
       61 tgctacgttc ggacccatag cgtgcatcag caagtagttg gtaggatcat attccagacc
      121 aacaacttgt gagatacgtg cagagtcggg aacggcagat acacctgcat taccgatcaa
      181 cggattgatc ttattgccct tcttgaggaa gaggttgaag atcttaacga agatcacacc
      241 tgatgcggta gcaatgataa atgacagtgc accgagggcg aagatcttga tggagtcgag
      301 tgtcaggaac tcggaagcct gagtagaggc acctacggtc aaacctaaca ggatagtgat
      361 aacgtcaatc agcggaccgc tggctgtgtt agccagacga cgggttacac cactttcttt
      421 caacaggtta ccgaagaaca gcatacccag cagaggcaga ccggaaggaa ccaggaagca
      481 ggtcagcaac agaccgataa tcgggaaaat cactttctct gtatgagaaa cggcacgtgg
      541 cggtttcata cggataacgc gttcgtgctt ggtggtgagc agacgcatga taggcggctg
      601 tatcaccgga actaacgcca tataagagta ggcggatacc gcaatggctc ccattaagtt
      661 aggtgccagc ttggacgaaa ggaagatagc cgtcggacca tctgctccac cgatgatacc
      721 gatagcaccg gcctgcatcg ggtcaaatcc catttccaat gcgatcatgt atgcaccgaa
      781 gataccaaac tgggcagctg caccgatcag catcagcttc ggattggaga tcagcgccga
      841 gaagtctgtc atggcaccga tacctaagaa gatgagcggt ggataccagc cggacgttac
      901 tccctgatac aatatgttca atacagaacc ttcttcatat ataccgactt ttagtccggc
      961 gtccatattg aagggtatat taccgatcag gataccgaat ccgataggaa ttaacaacat
     1021 cggctcgaac tctttggcta cagccaaata gatgaagaac aagccaacga ggatcatcac
     1081 gatatgacca actgtcgcgt tggcaaatcc cgtgtaggtc cagaagtcgg caaggttatt
     1141 tcctaaaaag ttaataaaat ctcccatatt attcaataat tacgaggtca ttaccttcaa
     1201 gaacagaatc tcccttgttg acattgatag cagtcacttt gccgtctttg tctgcattga
     1261 tattgttttc catcttcatg gcttccaata taatgatagt ctgtcctctt ttcactgtat
     1321 cacctacatt tactttgatg tcaaggataa cgcctggtag cggggactta acgcctgatt
     1381 tgcctgtaga aggagcagcc ggttttacta ccggtgtggt aggagcagcc ggtgagttag
     1441 gcataggacg tactactacc ggtttgggag cagttttcgg ttgtttctcc atttctactt
     1501 tgtagtgcgt accgttcact tctacatgag cgatattatc ttcaatatct ccgatggtta
     1561 ctttgtatga gttaccgttg attttatatt tatattcttt catcgtttta tctttttagg
     1621 gaatgattta ctttctgtta ggattttcac gcaaggtgta aatcttcgaa ctccacggtg
     1681 aataactgcg tttcacacga gtgatggtca gcaccgtttc ttctacgtcg tgtacctcat
     1741 cctgcatttc gtgtaatgcc attgaaatag cagcataaac ttcacccgga gcctgtgaaa
     1801 gctctttcgc ttcgacttta tcgatgcctt tagccttcat cgcattgcgt ttgctcaggt
     1861 tgacagcaac tttacctacc accttgaagg caatgaagag aagaatcaat ccgcagaata
     1921 ctacgctcat ggctgaaata gacataccga taccgactga gtcatgttct tcgaactttt
     1981 ccatcttggc attactgtca agggttttgt tgttcgtgct cggggttacg tatttgtctt
     2041 tgcttccgcc ttttacttcc cagtctgctg ctccgtcact tatgcgtgca taagactggt
     2101 tgggacctaa agttcctgct ggtatgacaa cttgatccag tagctttctg cctgaatcaa
     2161 aaagaccgac ccaattggct gtttcggggt tcagtttgaa gctggtatgg aaggttccac
     2221 gattaggttc gccatctgcc caaaataacg catgttggcg tggctttact aatgtaagta
     2281 tgtcaccttt cgggataaaa taggttactg tatcgcccgg ctggctgctt actttcaata
     2341 aacaagctgc taagtctgcg ctaccgtatg atttgttgaa tatttcaatc catgcactgt
     2401 gcaagccgta gtcatcctga aagttgtttt gattgtctat caggacttca ttcagcaata
     2461 gcttattgtt cgacttttgc tctccgcagg aagtcaatcc aatcagcaac agcagagaaa
     2521 ggaatattcc gattttggtt ttgttcataa tcgttcttgt tttaatgtga aaagtaggat
     2581 tacaacggaa tattaccatg cttcttagcc ggattactca atttcttagt ctgcaactgc
     2641 tgcaaagcac ggatgacgcg gaaacgtgtg ttgcgcggtt caatcacatc gtcgatgtag
     2701 ccatatttag ctgcattgta aggattggca aacagtttcg tgtattctgc ttctttctct
     2761 gcaaggaatt gagccgggtt ttcctgatct ttggcttcgc gtgcgtacaa tacttctact
     2821 gctcctgcac cacccattac tgcgatttcg gcagtaggcc atgcgtagtt catatcaccg
     2881 cgaagttgtt tacagctcat cacgatgtga gaaccgccgt aagatttacg caatgtgata
     2941 gtaaccttag gcacagtagc ttcaccgtaa gcatacaaca acttagcacc atgaaggata
     3001 acaccattgt attcctgacc tgttcccgga aggaatcccg gtacgtctac caacgatacg
     3061 ataggaatat tgaatgcatc gcagaaacgg acgaagcgtg cacctttacg agatgcgttg
     3121 ctatcgagca cgccagccag atatttaggc tgattagcaa cgatacctac cgactggccg
     3181 ttgaaacggg cgaaaccgat gatgatattc ttagcataat ctttctggat ttcaaggaat
     3241 tcaccgttgt ccacaatagc gccgatcact tcgtacatgt catacggttt ggtagggctg
     3301 tcggggataa tatcgttcaa agaatcttcc aggcggtcga ttgggtctgt gcaatctaca
     3361 taaggagctt cttcaaggtt gttttgagga atatagctca acagtttgcg aatcagctcg
     3421 aaaccttctt cttctgtttg ggcggtgaaa tgagtcacac ccgatttagt ggagtgaatg
     3481 cttgcgccac cgaggttttc ctggctgacg tcttcacctg taacggtctt caccactttc
     3541 ggtccggtga ggaacatata agaagtgcct tccatcatca gtgtgaagtc ggtcagagcc
     3601 ggagaataaa cagcaccacc ggcacaagga ccgaagatac cggaaatctg cggaataaca
     3661 cctgaagcaa ggatgttgcg ttggaagatt tctgcataac ctgccaaagc gttgatacct
     3721 tcctggatac gtgcaccacc cgagtcgttg ataccgatac aaggagcacc catcttcatg
     3781 gcctgatcca taattttaca aatcttcaat gacattgttt ctgacagtga accggcagaa
     3841 acagtgaagt cctgtgcgaa cacatatacc agacgtcctt cgattgtacc gcagccggtt
     3901 actacaccgt ctcccgggta atgctttttc tccatgccga agttcgtgca tctgtgctca
     3961 acgaacatgt ccatttcttc gaagctaccc tcgtcaagca gcatagccag acgctcgcgt
     4021 gctgtgtatt ttcctttttc gtgttgcttc gcaattgctt tttcaccgcc tccgatacgt
     4081 gctacggcac ggcgttcaat aagctcttta attttttcaa gttgattact catgagttct
     4141 tgttgttttt ttagagttta tgattagtgt tcgcagagtt ctgtcagcac acccagtgtt
     4201 gatttcgggt gaaggaaagc gatgttcaga ccttcggcac ctttgcgggg agccttgtca
     4261 atcagacgga tttctttgct ttctgcttct gccaaagcat tagctacgcc atcttctacg
     4321 gcaaatgcta cgtgatgaac acctgcacct ttgttttcaa taaatttagc aatggtgctt
     4381 tcggggcaag tcggctccaa caattcgatt tttgtttcac ctacctttaa aaaagcggtt
     4441 cttacttttt gatcttctac tgtttcgatg ttgtaacatt tcagacccaa tacgttttcg
     4501 tagtaaggaa gggcttcttc gatgcttttt acagcaatgc ccagatgctc aatgtgtgaa
     4561 atcttcataa ctatattttt ttatatggtt taattatgtg cttatatggc ataaaacagc
     4621 acaaagaaag acatttcttg tctaataaag aaatatttct gcatttaatt attggggaat
     4681 aaagcataaa aaatgctccg gatgggtgac aaagacgggt tttgtaatct tgagattaca
     4741 tttagacata aaacttgacc agaagattat tcagccatgg ccagctgata cggaaccagc
     4801 ggcgggtact gctttgtttg cctccgaaac ggagtacgaa atcacgataa ccatgcttgc
     4861 ggaagggaag tcctacatcc atgaactcca tgtgacggaa tccccgttca tgggcatctt
     4921 caagtgcttt ccatactgcc agtatgccgg gtgactgcag tgcataggtc tttcgcattc
     4981 ctcctgaaaa ccagataaaa gcattttcgc cggaatagat gcagacggag ccgccgataa
     5041 tcttttcctt gtattttacg atgaatattt ttgcctgttt tcctctgata agcatgctgt
     5101 tcatgtggcg gaaaaagtca ttggcaggga aatatctccg tattcgtgaa gaataaactt
     5161 tgtgcagcat ccgcgagaat tccttaatct cttccaccgt atgggcttct actactttgg
     5221 ctccgttttt gagccctttc cggatctgac ggatacgtga tgggctgaaa cggtcttccg
     5281 ctttctgcgt actatgcaga gagttacgga cacgcagcca gttgaccgga aaaaagtcgt
     5341 tctttcggaa gaaacggtaa ccgaacatgg aattatccag attgcggaat tcaataagaa
     5401 tgcaggtgcg tgatgcttct tgtgtgagat gctccagcat ttcaccgaaa atttcttcct
     5461 ccttctcttt acttgccggt agagaagtgt ccagaaattc acctgcacca tataccacac
     5521 attgtttgac aagagaggag ggaagccact ttttggtctt gcgtatggcg gcaagcaggc
     5581 gtgctacagg tctgccttct tctgttgcca ctatcagtag cggggtatat cccggagtcg
     5641 attcatagat ctgaaacaac tccttggaat gaaaagtatt ggttcccggt aaatcaggaa
     5701 tgtcttttcc gcgataatat gttgttagtt taagtggcat ccaaatacaa atttacactt
     5761 tttattcttc attcaacaat aaaaaagaga atttgttggc ttagcctaaa atttgtcttt
     5821 ttatcctttg catatatttg aggaaaaaaa ggcttggaaa agcgaatttt tgtattattg
     5881 tcgtcctttg tgagtacaga agtaaaatgg aaacgtctat gtaaaagatt atgctaattg
     5941 tattttacta aacaaaggaa aattaatatt aactttaaat taaaacgaat gagagagaat
     6001 gcatttgttg aagcgtggaa gacacagcat agacgcgttt ccatgatttt agggctgact
     6061 ttattgtgtg ccccttctgc catatctgtt tatgcagaaa atggtgtgaa tgatattact
     6121 gtgcaagccg tcatgcagac aaagacagtg aaaggaactg ttttagatga aaatggagaa
     6181 ccgttgctcg gtgtttctat tgtggtgaaa ggtacaagta caggtacgat aactgatttt
     6241 gacggtaagt tctccattaa tcttccggcc ggaagtaaag aactggttgt ttcttatatc
     6301 ggatataaag aacaggctat cattgtgagt ggaaatgccc cgctgaatat aaagatggtt
     6361 ccggatacac aggctttgga tgaggtagtg gtcatcggtt acggtacggt aaagaaacgt
     6421 gatttgacag gtgcggttgc ttctgtgaaa tcagaggata tcaccatgaa tccgggcgtg
     6481 aatccgatgg atgcgctgca aggtaaaatt gcaggtctgg atatcactaa ttcttcaggt
     6541 caggcaggtt cgtcaccgac agttcagttg cgtggtaccc gctctttaca gttggatgag
     6601 gatggtaata tctcttcaga tgcatttaag ccgacttata ttatcgatgg tatgccgggt
     6661 gatattgcta ccttgaatcc caatgatatt gaatctatcg aagtactgaa agatgcatct
     6721 tctacagcta tctacggttc aagtggtgcg aatggtgtta ttatcgtgac tacgaaagga
     6781 tccaagagtg gaaaaccggt catcaatttt aatgcttatg ccggaacgac tatgggtgcc
     6841 cgagttccta agatgcgtac gggtgactca tacattaatt atataaaaga ttcttataag
     6901 cctgtcggta ctaccaatga ggaggaaatt ttcggtgaaa gatacgatgc catcaaaaac
     6961 aaccaatggg taaactgggg agatgaagta ttacactcag gcttgaagca gaactatagt
     7021 atttccgttg ccggaggtac tgagaagacg aaagcttatt tctcgttgaa ctatactgat
     7081 gagaagagta tgtatgagaa tgatgactat aaagtgtact ctacccgtgt ccgtatagat
     7141 caggaaatca ataaatggat taatgccggt attaatgttc aggcatcttt ctccaacaag
     7201 aattcacgta atgccgtttt agaaagagca ttgtttgcta ccccattggg tgttccttat
     7261 aatgaagatg gctctatcac ggaattcccg attccaggtt catcatcaga cccgaatccg
     7321 ttagcagacg aacaggatgg agtatataag aataatacta aagcaggaag ggcttatgtt
     7381 gacgcttatc tggaatggaa accggtaaaa ggattgtctg tcaagtcaca gcttggaggc
     7441 agttattctc aatctcgtgc cggtaaattt atgggagaag gctcttataa tgtgttgaaa
     7501 ggcagtacgg tggcatatgg cgaagctacc aataagacgg gatataatta caaatgggaa
     7561 aacatagtaa cttatcacaa tacatttaat aaagctcatg acctgacaat tacaggggtt
     7621 acttcctgga attacaatca gagtgaagaa tattatgtct atggtgaaaa cccggcgacc
     7681 aatgatatgt tgtggtatgc attgcagaat gctgataata agaaactgaa cagcaaatat
     7741 ctgatgtcga aggggatggg ctttatcggt cgtgtcaact actcatacaa aggtaaatac
     7801 ctgttctctg cttccagtcg ttatgaagcg gattcccgtt tgtcgaaaga caatagatgg
     7861 aatttattcc cggcagtttc tgtaggctgg agaatctcgg atgaagcatt tatggctggt
     7921 acaaaaagct ggttggataa cttgaaactg cgtgtaggct atggtgttgc cggaactact
     7981 gccggtattg ctgaatacag ttctatggca tctttggaaa atgtgacaac ctctttggga
     8041 ggaatgactg ttccgtcagc caagtttacg gagtatatca ctaaccgtaa tctgacatgg
     8101 gaaaagactc atgacttgaa tattggtatt gacgccagct tcctcaataa tcgtattgat
     8161 ctgacggtgg atttgtatcg gacaaaaaca acggatgtaa ttctttcgca ggcattgccg
     8221 acatctatta tgggtaatta cacaggtagc actacttata aaatgaacaa gaatgctgct
     8281 gaaacagaaa atcgcggtat tgaacttgct cttaataccc gtaatattgt gaagaaagat
     8341 tttacttgga gctcaacagt gacatttacc gccaacaaag aaaaaattaa atctttgatc
     8401 gaagggcagg atatgatgtt caatgcaaaa aagggtgata tggtgttcaa agtcggcgaa
     8461 ggagtcggtt ctttctatag atataaagtg ttgggtatct ggcaatatag cgaaaaggaa
     8521 actgctgctt tgttcggatg cgaaccgggc gatattaagc tggatttacc tagtgtgaag
     8581 aaggacggaa atggttatta ttatatgaat cctgaaggag agcgcgttga tattacggca
     8641 gaaaatcctt atggtgtacg tgcggattat gatcgtcagg taataggtcg taatactccg
     8701 gactggacat tgggctttaa gaataatttc agatacaaag attttgattt gtctgtcttc
     8761 ctttatgcac gttgggggca aatgatgaac tatggcagtg tgataggtaa atattcgcct
     8821 aatccggatt acaatattcc tacttatttt acttactatg acaagacgat cgaagcagat
     8881 caggatgtct tgttctatgc tatcgataaa tccaaggata gaagtgctta tgaaggatat
     8941 gattcgatgt attatgtgga tggatcattc tttaaactta aaaacgtaac attgggttat
     9001 acgttacccg gtaaacttac aaaacgtttt ggtatcagta atctgagagt ttatgcgaca
     9061 atgaccaacc tgtttactta ttcgccaaac aaatatgtga agaattacga tccggaaatg
     9121 aacggaagca tcaacttccc attgtctcgt gattgcatat ttggtcttaa tttaactttc
     9181 taaaaaatag caatatgaaa aagatatata gtttagttct acttgttgcc ggtgtttttt
     9241 cttggggctc ttgcagtctt gatgaagtga accccaacaa ctcgggtcag ttctccgatg
     9301 gttcttatac attggaaact tataaggcat tcaccaactc gtgctataca gccttgatca
     9361 acaacatcta tcagagtagt gactatctgg tttgtacgga agcgggtact gatatttggg
     9421 aagaacccaa atcgggctcc agctatcagc gttatcatag ttataacggt atgaaaaccg
     9481 atgatagcta ttattataaa gtgtggcaat attcttatct gtgtatcaac agctgtaata
     9541 ttgtgattga cggagctgag aatgtgacag gggatgagaa tgaaatcaat gaatgtgtgg
     9601 cacaggccag atgtctgcgt gcttactatt atatgaattt ggtggagcag tttggaaatg
     9661 tcgatttgca gttgaaggct gccgatagcg agaatatttc ttttgatgct caccgttcta
     9721 ccgttcccga aatttatgct gccattatcg aagacctgaa gtttgccgta gagaatctgc
     9781 ccgtaagttt cagtgattac tatagccgcg ttacaaagaa atcggcgatg ggattattgg
     9841 cacgtgcata tattaatggt gccggttatg atctgaaaga taccgatggt gtcagctttc
     9901 tggaaaaagc ctatgatacg gcgacaacca tgattaataa taaagcgatt tatgagtggt
     9961 atatgcatcc tgcttttgcc gatgtattca acgaaaataa taatcgtaac aatgaagaag
    10021 ctctgttcat tgctgcgggt gccgaaagaa attcggacgc ttacaccaat ggtaactact
    10081 cacaaagtga aatgttccgt cacttcttac cttcgttggg aacatatacg gatctgggtt
    10141 tggtagacaa gacttcaaac ttcgtttacg gtcgtccgaa cagtaatatc ttcctgccat
    10201 ccaaatatct gatggactgt tttgctgctg atatgaacga ctctcgtttt cgttattcat
    10261 ttatctcagc ttactcgtct tattctatac cggcatgggg ggcgacttat gaatatggag
    10321 gttcagcgtg tgccaaagaa atcacaagca cacttgctac taaatttggt attcccgcat
    10381 ctaatatagg taagaaagtt tatcctcatt ttaacttgga atccaatagt acagccgatg
    10441 ctaattactg ccagctggct atctggaatg cagatggaac agcgaagact actcaggata
    10501 aaacagatgg taatattctt catcctgcta tgcctttaga tccggcagaa gctcatcaat
    10561 atgccgttta ttgttctttg aagacgctga cagaagagga aaaagctcaa tatccggggt
    10621 tggttcttaa tgttttcgat ctttacgatg agaatggaac agccagggct acctatgaca
    10681 agcctagtgc tgccagtgct ttgtggttat ctatttatcc ggctctttct aaattcaata
    10741 tgccgggtaa taagtttgtc ggcagagacg ttcagagaaa aactgtggat gtgatgatca
    10801 tgcgtatggc ggaagtttac ctgattgctg ctgaagcatc ggtacgcttg aacaagggag
    10861 atgctgccaa atatattaat gtactccgta cgcgtgccgg tgccggtacg gtcagtgagt
    10921 cgcaagtgga tctgaattat gttttcgatg aatatgcccg tgaactttgt ggcgaatgtg
    10981 gccgctggta tttgctgaaa cgtaatgctg cttttgagac tcgtttggct gcttataata
    11041 agcgtgctgc cgagcacttt aagaaagaat tctatttgcg tcctattcct acgaaatatc
    11101 tggatgcgat caataatccg gcagaattcg gacaaaacgc cggttattaa tcagttaatt
    11161 aataatcaag cataattaat aggagccggg caggagattt ctcttgtccg gctctttgtt
    11221 tccagacctg tatcctacgt aaaagtttaa aaaggatttc cggtatattt tcattatttc
    11281 ctgatacagc cttttattat tttctttatt tttgtgtgtc caaacaaaat agcgctatga
    11341 tagaagaaat gcttgcttat aatagagagt tcgttaagaa cgagggatat aaagaatata
    11401 taacgaataa gtatcccgat aaaaagattg ctatcttatc ctgtatggat acacgcctga
    11461 cagctttact cccggccgca ctaggcatta agaacggaga cgttaaaatg atcaagaatg
    11521 caggaggcgt catttcccat cctttcggta gtgtgattcg cagtctgctt gtcgctatct
    11581 tcgagttagg tgtggaggaa ataatggtga ttgcccattc tgattgtgga gcctgccata
    11641 tgcacagtga agaaatgctt gagaagatga aggcacgggg tattaatgcc gattatattc
    11701 atatgatgag tttttgtgga gtcgattttc attcttggct agatggcttt gaagatacgg
    11761 agaagtcggt aaggggaacg gtcgatttta tagttcatca tcctttgatt ccgtcggacg
    11821 tgaaagtgca cgggtttatc atagactcca ctactggaga actgacgcga attgtatagg
    11881 aaatcgccct ttctgcctat caggaactgc ataaaacatg gtgtcactat cgcaacagga
    11941 tagtgtcact atcactgtct catggtgtca ctatgtcatt gggataccga cactatccca
    12001 aatgaaaaaa ataaggcagc tttttatcgg ctgcctttat ctttctgcgg ttatatactt
    12061 tctttgactc atgcactcgt ttgtaacaaa cggggtgtcc gtgctctttg atttctgcct
    12121 cacggctggc tttacgattc gctttgatgt aatcgtcttg tgtaattcgt tttttcataa
    12181 tgaatatatt tctcagtgca aagatacaat ttcatttctt attacgatcg gtttgcgcta
    12241 tctttgcata cataaatcaa atgaaaacgg aaataatatg gaaaatttca gtgaactgat
    12301 aaagaatcgc cgcagtatgc gcaaatttac ggatgaggag ttaacacagg atgaggttgt
    12361 ggcactgatg aaagctgcct taatgtctcc cagttccaaa cgtagtaata gctggcagtt
    12421 tgtggtagtc gatgataaag aaaagttgaa agaactgtct cactgcaaag aacaggcttc
    12481 ttctttcatt gcagacgctg ctttggcgat tgtcgtgatg gcagatccat tggcgagcga
    12541 tgtctggatt gaagatgctt ctattgcttc catcatgata cagttgcagg cggaagattt
    12601 ggggctggga agctgttggg tacaggttcg cgaacgtttc actgcaaccg gaatgccgtc
    12661 tgacgagttt gttcatggaa ttttggatat tcctttgcaa ctgcagattc tttccgtgat
    12721 tgccatcgga cataagggaa tggaacgtaa gcctttcaac gaagaacacc tccagtggga
    12781 gaaaattcat attaataagt tcggaggaaa ataacgatgg gagctgtcaa agcaaataat
    12841 aataaagata cttataaggc tactgccgtc gcttttattg ttatcggaac tcttttcctg
    12901 ataaataaac tgctcccctt tgcttctata ggtttgcctt gggtgatgaa taaggacaat
    12961 ttgttgttgt atgcctctat cagttttctt attttcaagc gtgacaagtc ggtcggcttt
    13021 gtgctgttgg gactgtggct ggtaatgaat atcggtttgg taatgtcatt gctcggttcc
    13081 ttgtccggtt atctgttgcc attggcactg ttgatcatcg gaattatttt attttgggtt
    13141 tcaaaacgtt aaagaaacaa tgaaaagaag tattgaagat acgcccgttg tgtttctcgg
    13201 cgccggaaat ctggcaacta atctggcgaa agcgctttac cggaaaggat tccgtatcat
    13261 gcaggtgtac agccgaacgg aagaatcggc tcgtacgtta gccaatgaag tggaagcgga
    13321 atatatcact gatttaaaag gcgtatcgaa tgaagcgaga ttatatatta tttcattgaa
    13381 agatgccgct ttcgtcgaac tgttgcctca gatcactgat gggaagcagc atgcgctgct
    13441 ggtacatacg gcaggtagca tcccgatgaa tatttgggaa ggtcatgcgg aacgctacgg
    13501 agtattttat ccgatgcaga cgttcagcaa acaacgtgaa gttgattttc gggaagtacc
    13561 tttctttatt gaggcaaaaa gaccggaaga tgccgagctg ctgaaagcgg ttgccggtac
    13621 gctctctgat aaggtgtacg aagccgattc ggagcaacgc agaagtcttc atctggcagc
    13681 cgtctttacc tgtaacttta ccaaccatat gtatgctctt gccgccgaat tgctggaaaa
    13741 atatcatttg ccatttgatg tcatgcttcc cctgattgac gaaacggcac gcaaagtgca
    13801 tgaactcgct cctcgtgatg cgcagaccgg accggctgta cgctatgacg agaatgtgat
    13861 gaacaagcat ctttctatgc tggcaggcag tcaggcattg caggaaattt ataaattaat
    13921 gagtaaaagt attcatgagc accatcaatt atgatctatc ccgcatcaaa gcgctggctt
    13981 ttgatgttga cggagtattg agttcgacaa cagtcccgtt gcatccttcc ggagaaccga
    14041 tgcgtacggt gaatattaaa gacggttatg ccattcagct ggcagtaaag aaaggactcc
    14101 atattgctat cattaccggt ggacggacag aagcggtacg tatccggttt gcagcattgg
    14161 gtgtgaagga tctgtatatg gggtctgcag tgaaaattca tgattaccgt gatttccgcg
    14221 ataaatacgg tctgtctgat gacgaaattc tgtatatggg cgatgatgtg cctgatatag
    14281 aagtgatgcg tgagtgtggg ttgccttgtt gtcccaaaga tgcagttccg gaagttaagt
    14341 cggttgcgaa gtatatatct tatgccgatg gcggtcatgg ctgtggacgt gatgtggtgg
    14401 aacaagtatt gaaagctcat ggtaagtgga tggcggaaga tgctttcggc tggtgagttg
    14461 taaatcacta aatgataaat aaaactatgc ttggaaattt agataaatat cagattatat
    14521 tagcctccaa ttctccccgc cggaaagaac tgatgtcagg cttgggag
//
