LOCUS       c00147_gnlPro..        12644 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|EPOHAHHM_147.
ACCESSION   c00147_gnlPro..
VERSION     c00147_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-07 05:25:42
            Original ID  :: gnl|Prokka|EPOHAHHM_147
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 12644
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12644
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[7727:12644]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /neighbourhood="10000"
                     /product="TPP_fatty_acids"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      7728..12644
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /neighbourhood="10000"
                     /product="TPP_fatty_acids"
                     /protocluster_number="1"
     cand_cluster    1..12644
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /kind="single"
                     /product="TPP_fatty_acids"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..12644
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_fatty_acids"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /tool="gutsmash"
     CDS             complement(3..1022)
                     /locus_tag="ctg147_1"
                     /transl_table=11
                     /translation="MRISLALLFAVVLQLSAEDGYAQRTRVAISMNNVSVEQVLNKIEE
                     TSDYVFLYNDKTIQKNRIVSVRNNSGKILNILDEVFKGTNITYTVVDKQIILSTNKLNV
                     TEQEPTIQVKGTVKDTKGEPLIGVNVKVKGTTTGAITDFDGNFQIQAKKGAVLEISYIG
                     YASQEVKVTDNKSLSIVMTEDTKVLNEVVVTALGIKRETKSLTYNVQQIGGDEVAKAKD
                     MNVMSSLAGKVAGVNINASSSGIGGGARVVMRGTKSISGNNNALYVVDGVPLANISGEQ
                     PDDQYTGAGQSGDGLANFNADDIESISVLSGSAAAALYGSAAANGVVLITTKKGAVDKT
                     "
     CDS             1123..1293
                     /locus_tag="ctg147_2"
                     /transl_table=11
                     /translation="MNYGLIPASVCETLYRESGKFGGRQLLVAAFFLSFILLCYSMGFY
                     FKGYYSNINLL"
     CDS             complement(1274..2185)
                     /locus_tag="ctg147_3"
                     /transl_table=11
                     /translation="MSPESLLRKAQALGDDIKEMESIDVLGAYYQAQTKIKTNRRKNMY
                     NQLMRYAAFLTIPLFLSSLVLGYLYFSGTETDEKYAEVVTATGSVIRYELPDHSVVWLN
                     AGSTLRYPTTFKKDNRLVELKGEAYFEVQADKDRPFYVNTPNGLGIYVYGTKFNVAAYE
                     DDNYIETVLEKGKVNVITPDQETIALAPGEQLLYDKQSQKSEKNKVDVYGKIAWKDGKL
                     IFRNASLEEILKRLERHFNVEIQFNNRSGKEYKYRATFRTETLSQILDYLARSADLKWK
                     VEEPQQQADDTLSKTKIRVDLY"
     CDS             complement(2290..4281)
                     /locus_tag="ctg147_4"
                     /transl_table=11
                     /translation="MKNKFFLLAITFCLPIHSQGVSKSFIPMAEIPAGSFYMGSDGLGE
                     DFDEAPIHQVIISRPFRMGITEITNAQYESFRPEHRALRGKNGVSLEDDEAVVNVSYSD
                     AVAFCEWLSRKEGKNYRLPTEAEWEYACRAGTYTLFSTGDGLPAVYHRNQKVVRDFDPV
                     SLKVAQTPPNTFGLYDMHGNVEEWCLDWYAPYSAEKQKDPAGPLAGEFRVTRGGSHHTP
                     EKYLRSANRLAMLPEDKHSQTGFRIVEADTRLNVSGTSAPVPFNQESVKNASIKWKKVS
                     AVTPMFLPPIPFVVRPACDSNIPFYLHNHQPAVTWCDNGDLLAIWFSANEENGRGMAVL
                     GSRLRAGHTDWDVASLFFKVPDRNMTGSALLNDGKGKLYHINGVEASGDWQNLAMVLRT
                     STDNGASWSTPKLIAPEHTKRHQVIAGTIRTREGWLVQACDAGPGSHDGAAVQISKDEG
                     KTWCDPWDGAPLPDFKEGGTGSTIAGIHAGIVQLENGSLMAMGRGNSIRNKEGKLRMPM
                     SISDDMGKTWKYVASELPPIDGGQRLVLMRLNEGPLLLVSFTDHPQRTPLEERGLEFKD
                     KNGNVKKGYGMYAALSYDEGKTWPVRKLLTDGEYRFLNGGAWTGYFEMDENHAEPRGYL
                     AGTQTPDNVVHILSSRLHYRFNLAWLEK"
     CDS             4455..5018
                     /locus_tag="ctg147_5"
                     /transl_table=11
                     /translation="MKISFSKQTKERAFKQLYEEYYAPFCLYAKRFVDDKETREDIVSD
                     VFTSLWDKLDTDSFDLQSNTALAYIKMCVKNSCLNFLKHQEYEWSYAENIQKKAPVYET
                     EPDSIYTLDELYRMLYETLNKLPENYRTVFIKSFFEGKTHTEIAEEMNLSVKSINRYKQ
                     KTMELLRNELKEYMPLLLLLFLRA"
     CDS             complement(5356..6498)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1025:AMP-binding enzyme (Score: 54.9; E-value:
                     1.9e-17)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg147_6"
                     /sec_met_domain="AMP-binding (E-value: 3.3e-18, bitscore:
                     54.9, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIFDRQQQRLLLEGKEYTFEEISQLIVGGAEAHSPAYWDLYLFLN
                     EWFNDSPVITVHTSGSTGIPKELMVRKDQMMQSARLTCEFLNLKKGESALLCMNLRYIG
                     AMMVVVRSLVAGLNLIIRPASGHPLADIKEPLRFVAMVPLQVYNTLQVPEEKERLKQTD
                     ILIIGGGAVDEALETEIKHLPTAVYSTYGMTETLSHIALRRLNGASASEHYYPFPSVKL
                     SLSAENTLIIDAPLVCDETLQTNDIARIYPDGSFMILGRKDNVINSGGIKIQAEEMEKL
                     LRPFIPVSFVITSVPDQRLGQAVTLLLADQPDTEEIGNKLHEILEPYYRPKHILTIESI
                     PQTENGKINRAECRILAKQMLMTFYPHTLIQSLYSSVFQV"
     CDS             complement(6530..7555)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MR_MLE_C"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg147_7"
                     /sec_met_domain="MR_MLE_C (E-value: 4.5e-30, bitscore:
                     94.4, seeds: 401, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNCKIEIIPRLLHFKQPAGTSRGTYTTRKVWYLHFTSPDFPGRVG
                     IGECAPLPALSCDDLPDYEDILKRFCRQVEKEQGMWDKDVLCQYPSILFGLETAIWHFF
                     AGSWALSDTAFSRGEVGIQINGLIWMGDFDHMLSQIEKKMEAGFRCVKLKIGAIDFEKE
                     LALLRHIRTHFSSKEIELRVDANGAFSPGDAMEKLKRLSEFDLHSIEQPIRAGQWEEMA
                     RLTSESPLPVALDEELIGCNTLEEKKKLLATIRPQYIIIKPSLHGGICGGDEWIMEAEK
                     QHIGWWITSALESNIGLNAIAHWCATFNNPLPQGLGTGMLFTDNIEVPLEIRKDCLWFC
                     K"
     CDS             complement(7728..8552)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: ECH_1"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg147_8"
                     /sec_met_domain="ECH_1 (E-value: 1e-82, bitscore: 266.7,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPTQREWTTIREYDDILFDYYNGIARITINRERYRNAFTPTTTAE
                     MSDALRICREEADIDVIVITGAGDKAFCSGGDQNVKGRGGYIGKDGVPRLSVLDVQKQI
                     RSIPKPVIAAVNGFAIGGGHVLHVVCDLSIASENAIFGQTGPRVGSFDAGFGASYLARV
                     VGQKKAREIWFLCRKYNAQEALDMGLVNKVVPLEQLEDEYVQWAEEMMLLSPLALRMIK
                     AGLNAELDGQAGIQELAGDATLLYYLTDEAQEGKNAFLEKRKPNFKQYPKFP"
     CDS             complement(8556..10223)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg147_9"
                     /sec_met_domain="TPP_enzyme_C (E-value: 7.1e-08, bitscore:
                     22.0, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYTDKKNILQLVALLEAHGITKVVLCPGSRNTPIVHTLSNHPNFT
                     CYAVTDERSAGYFAIGLALNGGKPAAVCCTSGTALLNLHPAVAEAFYQNVPLVVISADR
                     PAAWIGQMDGQTVPQPGVFQTLVKKSVNLPEIHTEEDEWYCNRLVNEALLETNHHGKGP
                     VHINVPISEPLFQFTVDALPEVRVITRYQGLNVYDRDYNDLVDRMNKYQKRMIIIGQMN
                     LIYLFEKRYIKLLYKHFAWLTEHIGNQTVPGIPVKNFDAALYAMPEEKIDQMVPELLIT
                     YGGHVVSKRLKKFLRQHPPKEHWHVSPEGEVVDLYGSLTTVIEMDPFEFLEKIASLLDN
                     RTPDYPRVWENYCKIIPEPDFAYSEMLAVGTLLKALPESCALHLANSSVVRYAQLYSIP
                     PTIEVCCNRGTSGIEGSLSTAVGYAAASDKLNFIAIGDLSFFYDMNALWNINVRSNLRI
                     LLLNNGGGEIFHTLPGLDMSGTSHKFIAAVHKTSAKGWAEERGFLYLQAQNDEELTEAM
                     KTFTQPETMEQPVLLEVFTNKNKDARMLKNYYHQLKQK"
     CDS             complement(10243..11358)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Chorismate_bind"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg147_10"
                     /sec_met_domain="Chorismate_bind (E-value: 8.2e-58,
                     bitscore: 185.5, seeds: 119, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDEEISNLTTIDAFIQRKQPFAVYRIPGEKVPRLLTQAEGAVCL
                     IYDLKELNGQRGFVIAPFQVSETCPVVLIQPDQWGQPLPIDNDTAEEREVALRMQGQES
                     FLTSSTEEYASCFHTFINALRDNTFDKLVLSRHLTIDKVSGFSPLSIFRAACRRYIHSY
                     IYLCYTPQTGIWLGSTPEIILSGEKDEWNTVALAGTQPLQDGKLPQIWDEKNRKEQAYV
                     ASYIRRQLLSLGIHSTENGPYPAYAGALSHLKTDFQFSLKDNKGLGDLLKVLHPTPAVC
                     GLPKEEAYRFILQNEGYDRRYYSGFIGWLDPEGRTDIYVNLRCMHIEDEQLTLYAGGGL
                     LASSELNDEWLETEKKLQTIKRLIATPPLKS"
     CDS             complement(11355..12644)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: HBT"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg147_11"
                     /sec_met_domain="HBT (E-value: 1.8e-18, bitscore: 56.4,
                     seeds: 132, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LSVVHSISYLCNLNQNRVIMKYKLLVLDVDGTLLNDAKEISKRTL
                     AALLKVQQMGVRIVLASGRPTYGLMPLAKMLELGNYGGFILSYNGCQIINAQNGEILFE
                     RRINPEMLPYLEKKARKNGFALFTYHDDTIITDSPENEHIQNEARLNDLQIIKEEEFSA
                     AVDFAPCKCMLVSDDEEALLGLEDHWKRRLNGALDVFRSEPYFLEVVPCAIDKANSLGA
                     LLEVLGMKREEVIAVGDGVCDVTMIQLAGLGIAMGHSQDSVKACADYVTASNEEDGVAV
                     AVEKAIISEVRVAEIPLDQLNAQARHALMGNLGIQYTYADEDRVEATMPVDHRTRQPFG
                     ILHGGATLALAETVAGLGSMILCQPDEIVVGMQVSGNHISSAHEGDTVRAVGTVVHKGR
                     SSHVWNVDVFTSTNKLVSSIRVVNSVMKKR"
ORIGIN
        1 ctggttttat ctacagcccc tttcttcgtt gtgataagta ccacaccatt ggcagcagcc
       61 gaaccgtata gtgcagcggc ggccgatccg ctaagtactg aaattgattc tatatcatca
      121 gcgttgaagt tagccaatcc gtcaccggat tgtccggcac ccgtatactg atcgtcgggt
      181 tgttcacctg atatattagc caaaggaact ccatctacta catatagagc gttgttatta
      241 ccggatatag acttcgtacc acgcattacc acacgggcac cacctccaat accggatgaa
      301 cttgcattga tattcacacc cgccacctta ccggcaagac tgctcatcac attcatatct
      361 ttcgcctttg ccacttcgtc gccgccaatc tgctgcacat tgtatgtcaa ggacttggtt
      421 tcgcgtttaa tgcccaaagc cgttacaaca acctcattca agacttttgt atcttccgtc
      481 atcacaatgg aaagcgattt attatctgta accttcacct cttgagaagc atatccaata
      541 taagagatct ccaataccgc tcccttttta gcttgaatct gaaagtttcc gtcgaaatct
      601 gtaatagcac cggtagttgt tccttttact ttcacattca ctccgatcaa aggttcacct
      661 tttgtatctt tcactgtacc ttttacctga atagtcggtt cttgctctgt tacattcaat
      721 ttattggtag acaagataat ctgcttatca accactgtat aagtaatgtt ggttccttta
      781 aacacctcat caagaatatt caggatctta cctgaattgt ttctcacaga aacaatacgg
      841 ttcttctgaa ttgttttatc attataaagg aaaacatagt cggacgtctc ctctatttta
      901 ttcagtacct gttctacaga tacattgttc attgaaatgg caacccgtgt tcgctgggca
      961 tagccatctt cggcagaaag ttgtaatact actgcgaaaa gtagtgctag actaatcctc
     1021 ataactaaag gaagttttag atttaaagca tatttaggac ataatgctgt aaatgaatga
     1081 ttttttttca tacatttgtg gctaactaaa gtttattact aaatgaacta tggtttgatt
     1141 ccggctagtg tttgcgagac cttgtaccgt gaatctggaa aattcggagg aagacagctg
     1201 ttggtagcag ctttcttcct ttcttttatt ctcttgtgtt attccatggg cttttatttt
     1261 aagggttact actctaatat aaatctactc taattttagt ctttgataat gtatcatctg
     1321 cctgttgctg cggttcttca actttccatt ttaaatcggc agacctggcc agataatcca
     1381 atatctgcga cagagtttca gtccggaaag tagcccggta cttatattct tttccagacc
     1441 tattgttaaa ctgaatttct acattgaaat gtcgttccag gcgcttcagg atttcttcta
     1501 atgaagcatt tctgaaaatt agttttccat ctttccaagc tatctttcca tagacatcca
     1561 ctttattttt ttccgacttt tgactctgtt tgtcgtaaag caactgttct ccaggagcca
     1621 atgctattgt ttcctgatcg ggagttatca catttacctt acccttttcc aatactgttt
     1681 ctatataatt atcatcctca taagcagcta cattaaattt agttccatac acatatatgc
     1741 ccaagccatt cggagtattt acatagaaag gacgatcttt gtctgcctgc acttcgaaat
     1801 atgcttcacc cttcagttct accaaccggt tgtctttctt gaaagtggta ggataacgca
     1861 atgtactacc tgcattcaac catactacag aatgatccgg aagttcataa cgtatgacag
     1921 aaccggtagc ggttaccacc tctgcatatt tctcgtcggt ttctgttcca ctaaaatata
     1981 aatatcccaa aaccagagaa gagagaaata aaggtatagt cagaaatgct gcataacgca
     2041 tcagttgatt atacatgttc tttcttctat tagtttttat tttggtttgt gcttgataat
     2101 aggcacccaa tacatcaatg gattccattt ctttaatatc atctcccaat gcttgtgctt
     2161 tacggagcaa tgattccgga ctcatatttt ccatattttc tttcaaaatc ttatctttta
     2221 attgtaatta cacttataat acaactgaag taattggaaa aggacagcaa aaacaaactt
     2281 ttttttattt tatttttcga gccatgccaa attgaagcgg taatgcaatc ggctactaag
     2341 gatatgaacc acattatcag gagtttgtgt tcctgcaaga tagccacgtg gttcagcatg
     2401 attttcatcc atttcgaaat atcccgtcca tgctccaccg tttaaaaagc gatattcacc
     2461 gtccgtcagt agttttctta ccggccatgt ttttccctca tcgtaggaaa gagccgcata
     2521 catgccatat cctttcttca catttccatt tttatcttta aattccagac cacgttcttc
     2581 caaaggcgta cgttgcggat ggtctgtaaa agaaaccaat agcaaaggtc cttcattcag
     2641 tctcattaaa acaagacgct ggcctccgtc aataggagga agttcacttg ctacatattt
     2701 ccaggtcttt cccatatcat ctgatatgct cattggcatt cggagttttc cttctttatt
     2761 ccgtatgcta ttaccacgcc ccatagccat caaacttccg ttctctaatt gtacaatccc
     2821 cgcatggata cctgcgattg tacttcccgt tcctccttct ttgaaatccg gcaaaggagc
     2881 gccatcccaa ggatcgcacc atgtttttcc ttcatcttta ctgatttgaa cagctgcccc
     2941 atcatgactg ccgggacccg catcacaggc ttgaaccagc catccctcac gtgtgcgaat
     3001 cgtaccagct attacctgat gacgtttggt atgttcggga gctatcagtt taggagtgct
     3061 ccatgaagca ccgttatctg tactggtacg tagtaccatt gcgagattct gccagtcacc
     3121 cgatgcttcc actccattga tatgatacaa ttttcccttc ccgtcattga gcaaagcgct
     3181 tcctgtcata ttccgatccg gaaccttaaa gaataaagaa gccacatccc aatcagtatg
     3241 cccggcacgc aagcgggaac cgagtactgc catccctctc ccattctctt catttgcaga
     3301 aaaccatatt gccagcaaat ctccattatc acaccacgta actgcaggct gatgattatg
     3361 cagataaaat gggatattcg aatcacatgc cggacgtacc acaaatggta tcggaggcaa
     3421 aaacatcggt gtgacagcag atactttttt ccattttata gatgcatttt ttacagattc
     3481 ctgattgaac gggacagggg cagatgttcc cgatacattc aaacgagtat cggcttccac
     3541 aattctaaat ccggtttggg aatgtttatc ttccggaagc atagccagtc gattggcact
     3601 tcgcaagtat ttctccgggg tgtgatgact ccctcctcta gtgacccgaa actctcctgc
     3661 caatggtcct gccgggtctt tctgcttttc tgcggaataa ggagcatacc aatccaagca
     3721 ccattcttcc acatttccat gcatatcata aagcccgaat gtattaggag gagtctgggc
     3781 tacttttaaa gataccggat caaagtcacg aaccactttt tgattccgat gataaactgc
     3841 aggtaacccg tctcctgtag aaaatagtgt gtatgtgcct gcccgacaag catattccca
     3901 ttccgcttct gttggcaaac gatagttttt gccttctttc cggctaagcc attcacaaaa
     3961 ggcaacagca tcggaataac tcacattgac aactgcttca tcatcttcca gcgaaacacc
     4021 gttttttcct cgtaatgccc gatgttccgg acggaatgat tcatattgcg cattcgttat
     4081 ttcagtgatt cccatacgaa acgggcgaga gattattacc tgatggatag gagcctcatc
     4141 aaaatcttcg cctaatccgt cacttcccat ataaaaactt ccggcaggta tttcagccat
     4201 cggaataaaa gacttggaaa ctccttgaga atgtattggc aaacaaaagg ttatagccaa
     4261 taaaaaaaac ttgtttttca tattttaatc ccgtttatat ataatacaat caacctatat
     4321 acaaaaggac agcctcatct gattattttc tattcattag tgttgaaagc aaaaaaaaga
     4381 atcgaaaatt aggctttgat aattatctta ttatatattt gcaacgaaat gaaaaactac
     4441 agaacctcaa aataatgaaa atatcttttt ctaaacagac taaagaacgg gctttcaaac
     4501 aactttatga ggagtattat gccccatttt gtttgtatgc aaaaaggttt gttgatgata
     4561 aagaaacacg tgaagacatc gtttcggatg tattcacctc attatgggat aaactggata
     4621 ctgattcttt tgatcttcaa tcgaacaccg cattagctta catcaaaatg tgcgtaaaaa
     4681 atagctgcct gaatttcctg aaacatcagg aatatgaatg gagctatgcg gaaaatatac
     4741 agaagaaagc tcctgtctat gaaacagaac cggatagtat atatactctt gatgagctat
     4801 acagaatgtt gtatgagaca ttaaacaaac ttcccgaaaa ctatcgaacg gtctttatta
     4861 aaagtttctt tgaaggcaaa actcatacag agattgcaga agagatgaat cttagcgtga
     4921 agtctatcaa tcgatataaa caaaaaacga tggaactttt acgtaatgaa ttaaaggagt
     4981 atatgccact attactcttg ttatttcttc gtgcataatc tacatcctca tgttctcttc
     5041 ctggtatatg cctttctttt gaaaaacagt cgtactctat atatgtatta gtcctgttgt
     5101 ttatatcact ctgcttaata gttagcaggg gcttacttgt gtggacagat aagctatcag
     5161 ttgtgaacaa atccgtttac ggttgtaaac agatttgttc acatgggtga gcccttgtaa
     5221 aacattagag cttaacaaaa gaatacctaa gtatcaatgt atgatatata gggaaatata
     5281 gtataaatta gctgggagca agacgagcca gggtgagggt aactttttac cctcaccctg
     5341 gcctcacctc taccctcaca cttgaaacac cgatgaataa agggattgaa tcaaggtgtg
     5401 agggtaaaac gtcatcaaca tttgtttggc taagatgcga cactctgccc ggtttatttt
     5461 tccgttctct gtttgcggaa tggattctat tgtcaatata tgcttgggac gataataagg
     5521 ttccagtatt tcatgtagtt tatttccgat ttcttctgtg tcgggctgat ctgccaataa
     5581 taaagtgaca gcctgcccta agcgctgatc cggaactgaa gtaatgacaa aggacacagg
     5641 aataaacggg cggagcaact tctccatctc ctctgcttga atcttaattc ctccactgtt
     5701 aatcacattg tctttccggc ctagaatcat aaaacttcca tcgggataga tacgtgcaat
     5761 gtcattggtc tgcaatgttt cgtcacatac caaaggggca tcaatgatta atgtattctc
     5821 tgcggataaa gacaatttta ctgaaggaaa tggataataa tgttctgaag ccgatgctcc
     5881 gttcagacga cgaagggcaa tatgcgacaa agtttcagtc atgccataag tggagtaaac
     5941 agcagtcgga agatgtttta tctccgtttc cagagcctca tcaacggctc cgcctcctat
     6001 aatcagaata tccgtttgtt ttaatcgctc tttttcttcg ggaacctgca acgtgttata
     6061 aacttgcaat gggaccattg caacaaatct caaaggttct tttatatccg ccaacggatg
     6121 gccggaagca ggacgaataa tcaaattcaa acctgcaacc aatgaacgta cgaccaccat
     6181 cattgcaccg atataacgga gattcataca taataatgcc gactcacctt tcttcaaatt
     6241 cagaaattca caagtcagac gtgcactttg catcatttga tccttgcgta ccatcagttc
     6301 tttaggtata cccgtggagc ccgatgtatg aactgtaata acaggagaat cattaaacca
     6361 ttcgttcagg aaaagatata aatcccaata agcaggagaa tgagcttctg ctcctcctac
     6421 tatcagttgg cttatttctt caaaagtgta ttcttttcct tccagtagca agcgctgttg
     6481 ttgtcgatcg aatatcatca gaatatcctt taaataccac taaataccat catttacaaa
     6541 accacaggca atcttttctg atttcaagag gcacttctat attgtcagta aagagcatac
     6601 ccgttcccaa tccttgtggt aacggattat tgaatgttgc acaccaatgg gcgatagcat
     6661 tcaaaccaat gttggactcc aaagcggaag tgatccacca gccgatatgt tgcttttccg
     6721 cttccataat ccattcatcc cctccacata ttcctccgtg gagagatggt ttaatgatga
     6781 tatattgcgg acggatggtt gccagcagtt tctttttttc ttccagcgtg ttgcatccta
     6841 tcagctcttc atccaatgct actggcaacg gagattcaga agtgagccga gccatttctt
     6901 cccattgtcc ggcacgaatc ggctgttcga tagaatgtaa atcaaattct gacagacgtt
     6961 tcagtttttc cattgcatca cccggagaga aagcaccgtt tgcatctaca cgcaactcta
     7021 tttctttaga agagaaatgg gtacgaatat gacgtaacaa cgccaattct ttttcaaaat
     7081 cgatagcacc aatctttagt ttgacacaac ggaatccggc ttccatcttt ttctcgattt
     7141 gggataacat gtgatcaaaa tctcccatcc aaatcaaacc attaatttga atccctacct
     7201 ctccacgaga aaaagccgta tcggacaaag cccaactccc tgcaaagaaa tgccagatag
     7261 ccgtttccaa gccaaataag atggaaggat actggcataa aacatcctta tcccacattc
     7321 cttgttcttt ctctacttgc cgacaaaatc tttttaatat atcttcataa tcaggaagat
     7381 cgtcacaact taaagcgggc aaaggcgcac actcccctat tcctactctg ccagggaagt
     7441 caggcgaggt aaaatgaaga taccaaactt tacgcgtagt atatgttcct ctggaagtcc
     7501 cggcaggttg cttgaaatgg agcaatcggg gaataatttc tattttacaa ttcatcgtga
     7561 ataatttttc aattcaccac agaataacac agagcctcac gaagttttaa taagttatat
     7621 ctcttgcagt tctcctacca ttctctcctc cacagtcttg ctttgcagaa aatcaggctt
     7681 aaacgcagga aaagcaaact ctgtggtact ctgtggcaaa gccgatttta agggaatttc
     7741 ggatattgtt tgaagttcgg tttacgtttc tccaggaacg cattctttcc ttcctgtgct
     7801 tcatccgtca ggtaataaag taatgttgcg tcacctgcca actcctgaat acctgcctgg
     7861 ccgtccagtt cggcattcaa tcccgcttta atcatgcgca aagccaatgg actaagcaac
     7921 atcatttctt ccgcccattg cacgtattca tcttccagct gttccaaagg tactacctta
     7981 ttcaccaatc ccatatccaa tgcttcttgt gcattatact tgcggcaaag gaaccaaatt
     8041 tcacgtgctt tcttctgtcc taccacacgc gccagataag atgcaccgaa tccggcatca
     8101 aaactaccca cgcgaggacc tgtctgaccg aaaatggcat tttccgaagc aatggataaa
     8161 tcacatacta catggagcac gtgtccgcca ccaatggcaa agccgttcac ggcagcaatc
     8221 acaggtttcg gaatactacg gatttgcttt tgtacatcca atacgctcaa acgaggcaca
     8281 ccgtctttcc cgatatatcc gccacgtcct ttcacattct ggtcgcctcc cgaacagaat
     8341 gccttatcac cggctccggt aattacaatc acatcaatat ccgcttcttc acggcaaatg
     8401 cgcaatgcat cactcatttc ggcagtggta gtcggggtaa atgcattccg ataacgttca
     8461 cggttgattg tgatacgggc aattccatta taataatcaa aaagaatatc gtcgtattct
     8521 ctgatggttg tccactctct ttgtgttggc ataatttatt tttgttttaa ttgatgataa
     8581 taattcttca acatacgtgc atccttgttt ttgttggtaa acacttccag gagcacaggt
     8641 tgttccatag tttccggctg ggtgaaagtt ttcattgctt cagtcagctc ttcatcattt
     8701 tgtgcctgca gataaaggaa accacgttcc tccgcccagc ctttggctga cgttttatga
     8761 actgctgcaa taaatttatg tgaggtgccc gacatatcca atcccggtaa agtatggaaa
     8821 atctctcctc ctccgttatt taataaaagg atacgcaggt tggaacggac gttgatattc
     8881 cacaacgcat tcatatcata gaagaaactt agatctccga tagctatgaa attcagtttg
     8941 tcggaagctg ccgcataacc gacagcggta gacaacgacc cttcaatacc acttgttccc
     9001 cgattgcaac aaacttcaat tgtaggagga atcgaatata gttgtgcata acgaactacc
     9061 gaactgtttg ccagatgcaa tgcacaggac tccggcaaag ctttcaataa tgtaccgaca
     9121 gccaacatct ccgaataggc aaaatccggt tcgggaataa tcttacaata attctcccat
     9181 acacggggat agtcaggagt ccggttatcc agcaggctgg cgatcttctc cagaaattca
     9241 aacgggtcca tctcgatcac tgtagtcaat gagccgtaca aatcgaccac ctcaccctcc
     9301 ggcgatacgt gccaatgctc tttaggcgga tgctgacgga gaaacttctt caatcgtttg
     9361 gaaacgacat gtcctccgta agtaatcagc aattcgggaa ccatctggtc tatcttctct
     9421 tcgggcatgg cataaagtgc cgcatcgaaa ttctttaccg gaataccggg aactgtctga
     9481 ttgccgatat gttccgtcaa ccaggcaaaa tgtttatata ataacttgat atatcttttt
     9541 tcaaacagat aaataaggtt catctgaccg atgataatca tgcgcttctg atatttattc
     9601 atccggtcga ccagatcatt ataatcacgg tcatagacgt tcaatccctg ataacgggtt
     9661 atcacacgta cttccgggag tgcatctacc gtgaattgaa acagcggttc ggaaatagga
     9721 acattgatat gcaccgggcc ttttccatga tgattcgtct ccagcaaggc ttcattcacc
     9781 aggcgattac aataccattc atcttcttcc gtatgaatct ccggaagatt gaccgacttc
     9841 tttaccagcg tttgaaacac acccggttgc ggcactgtct gtccatccat ctgtccgatc
     9901 caggcagcgg gacggtctgc tgaaatgaca actaaaggaa cattctgata aaatgcttcg
     9961 gctacagccg gatgaagatt taataatgca gtaccggaag tgcagcacac agcagcaggc
    10021 ttaccaccat tcaacgcaag accaatggca aaataaccgg cactccgttc atccgtcact
    10081 gcataacagg tgaagttcgg atgattagac aaagtatgta cgatgggcgt attacgacta
    10141 cccggacaca acacaacctt agtaatcccg tgcgcctcga gcaacgcaac caactggagt
    10201 atgttcttct tgtctgtata catgatgata attattagta gtttatgatt ttaaaggagg
    10261 cgttgcaata agccgtttga tggtttgcaa cttcttttcc gtttccagcc attcgtcatt
    10321 caattccgaa gaagccagta gtccaccgcc ggcataaaga gtcagttgtt catcttcaat
    10381 atgcatgcag cgcagattca catagatgtc agttcgccct tccgggtcca gccagccgat
    10441 aaagccggaa taatagcggc ggtcgtagcc ttcgttctgc aatataaacc gataggcttc
    10501 ttctttcggt aaaccgcata cagcaggcgt tggatgcaac actttcaaga gatctcccaa
    10561 acctttgtta tctttcaaag aaaactggaa atctgttttc aaatgtgaca aagcacctgc
    10621 ataagccgga taaggcccgt tctccgtaga atgaataccc aacgaaagga gttggcgacg
    10681 aatgtaagaa gctacataag cctgctcttt ccgattcttt tcatcccata tttggggcag
    10741 tttaccatct tgcaaaggct gtgtcccggc caacgctact gtattccatt catctttttc
    10801 acccgataaa atgatttcgg gagtgcttcc caaccagatt cctgtctgcg gagtgtagca
    10861 caagtatata tatgaatgaa tataacgcct gcaagctgca cgaaatatag ataaagggga
    10921 aaaaccggat actttatcaa tagtaagatg acgtgaaagt actaatttat caaaagtatt
    10981 atcacgcaaa gcatttataa aggtatgaaa gcaggaggca tattcctccg tagaagaagt
    11041 caggaacgat tcttgtcctt gcatccgcaa agcgacttcc cgttcttctg ccgtatcatt
    11101 gtcaatcggc aaaggttgcc cccactgatc gggttgaatc aatacgacag gacacgtctc
    11161 actcacctga aacggagcga tgacaaatcc tctctgtcca ttcagttctt tcaggtcgta
    11221 tatcagacat accgctcctt ccgcctgtgt caacagacgg ggaactttct ccccgggaat
    11281 acggtaaaca gcaaacggct gcttccgctg aataaatgca tcaatagttg tcaaattact
    11341 tatttcttcg tcggtcatct ctttttcatc acactgttga ctacccgtat ggaagacact
    11401 agtttgtttg ttgaagtaaa cacgtctaca ttccatacat gggaggaacg tcccttatgt
    11461 acaactgttc ctactgcacg cactgtatct ccttcatgtg cagaagatat gtggtttcca
    11521 ctgacctgca ttcctactac aatctcgtcc ggctggcaaa gaatcattga accgagtccg
    11581 gcaactgttt ccgccaatgc aagagtagcc ccgccatgca aaatgccaaa aggctgacgg
    11641 gtacgatggt ctaccggcat tgttgcttcc acacggtctt cgtcggcata ggtatattga
    11701 attcccaagt ttcccatcaa tgcgtggcgt gcctgcgcat tcagttggtc aaggggaatt
    11761 tcggctacac gcacttcgga tatgatagcc ttctccactg caacggccac tccgtcttcc
    11821 tcattcgaag cagtcacata atcggcacag gctttcaccg agtcttgtga atgtcccata
    11881 gctataccca gccccgccaa ttgaatcatt gttacgtcac acacaccgtc gcccacagca
    11941 atcacttcct cacgcttcat acctagcacc tccagcaaag cacccaaaga attggctttg
    12001 tcgatggcgc agggaactac ttccagaaaa tagggctccg aacggaatac gtccaacgcc
    12061 ccattcagtc gtctcttcca gtgatcttcc aaaccaagca atgcttcttc gtcatcgctc
    12121 accagcatac acttacaagg agcaaaatca acggcagcag aaaattcttc ttctttgatt
    12181 atttgcaggt cattcaaccg ggcttcattt tggatatgtt cattttcagg agaatccgtt
    12241 atgatcgtat catcatgata agtgaataaa gcaaaaccgt ttttacgggc tttcttttcc
    12301 agatacggca acatttcggg attaatccga cgttcaaaca gaatttctcc gttttgtgca
    12361 ttgataatct gacagccatt ataggaaagg ataaaacctc catagtttcc aagttcgagc
    12421 atcttggcca gcggcattag gccataagtc ggtctgccgg acgccagcac aatacgtact
    12481 cccatttgct gaaccttcaa cagggcagcc aatgtacgtt tactaatttc tttcgcatca
    12541 ttgaggagtg ttccgtctac atcaagaacc aataatttat acttcatgat tacacgattt
    12601 tgatttagat tacaaaggta ggaaattgag tgaacgacag aaag
//
