LOCUS       gnlProkkaADHMCKEM_318   4661 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|ADHMCKEM_318.
ACCESSION   gnlProkkaADHMCKEM_318
VERSION     gnlProkkaADHMCKEM_318
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-18 00:20:22
            Original ID  :: gnl|Prokka|ADHMCKEM_318
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 4661
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..4661
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[2:2282]"
                     /cutoff="0"
                     /detection_rule="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      3..2282
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="0"
                     /detection_rule="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS-like"
                     /protocluster_number="1"
     cand_cluster    1..4661
                     /SMILES="NC([*])C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX))"
                     /kind="single"
                     /product="NRPS-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..4661
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NRPS-like"
                     /region_number="1"
                     /rules="cds((PP-binding or NAD_binding_4) and (AMP-binding
                     or A-OX))"
                     /tool="antismash"
     CDS             3..2282
                     /NRPS_PKS="Domain: AMP-binding (10-351). E-value: 2.1e-77.
                     Score: 252.3. Matches aSDomain:
                     nrpspksdomains_ctg318_1_AMP-binding.1"
                     /NRPS_PKS="Domain: PP-binding (459-518). E-value: 2.5e-10.
                     Score: 32.7. Matches aSDomain:
                     nrpspksdomains_ctg318_1_PP-binding.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRPS-like: AMP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRPS-like: PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     237.2; E-value: 4.7e-72)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg318_1"
                     /sec_met_domain="AMP-binding (E-value: 2.4e-87, bitscore:
                     281.5, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 2.2e-11, bitscore:
                     32.7, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDPSGLRNICIGVCMERNKILVPAILAIFRLGATYLPIDPSLPD
                     NRKRYMAENADMVLLLTDSSNEVGGIPSVRQLYLNGEQLSEPVVGDYTEVLPDDCAYII
                     YTSGTTGNPKGVRISYRNLDTFTRNLVDKKLYHLSDPANRYLAFASISFDASILELMMC
                     IPVGGTLILAGEDERRDISLLDELIRREKVNIAFFPPSLLGMFADLDFPSFKTLLFGAE
                     AIGEKLFNRLKQQPYRLMNVYGPTENTVLSTIRIVGKDTSYDDIGYPLKGTVCYVLSEN
                     LQQTTLGATGELCLGGPQVSLGYIGSVQLNEKSFISYDGERLYRTGDLVQQQPDGSIRF
                     IGRKDTQVKIRGFRIELTEIAERLNRDPDVERAHVVVVERNGRQLLGAYLQPSVSGNFH
                     PEEVKERLRAELPYYMIPNLWQVVDHFQRTINDKIDVRALPAFTSLELKYVPPVHPGEV
                     ILCGILKEMLGLPQVSVEADLIDDLGLTSLDMLRLVTEANKKGCPINVSAVYTARNLRR
                     LLLVPRQEPIYWYRQQNLKKPVIILVCGSAYFNHLYFNLADRLYPKYDFLVVDAIYDHF
                     NKVATDIPELLEYYVRTVQPMIRERTVYALTGFCMGAELAVGLAEMLHRSMGIMPKVFA
                     LDGQAWQNPALCQNYPLLVFPGDTDEMVRERNEIINNYFRTTPNLIYQGEVIVLLSGLF
                     HQQAGLSPEESWTEESYRIFRTEYDNCERLWNKYYPNAPVLRLPTDHWHFLEGESLEQL
                     ITVFLK"
     aSDomain        33..1055
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg318_1_AMP-binding.1"
                     /evalue="2.10E-77"
                     /label="ctg318_1_AMP-binding.1"
                     /locus_tag="ctg318_1"
                     /protein_end="351"
                     /protein_start="10"
                     /score="252.3"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="CIGVCMERNKILVPAILAIFRLGATYLPIDPSLPDNRKRYMAENA
                     DMVLLLTDSSNEVGGIPSVRQLYLNGEQLSEPVVGDYTEVLPDDCAYIIYTSGTTGNPK
                     GVRISYRNLDTFTRNLVDKKLYHLSDPANRYLAFASISFDASILELMMCIPVGGTLILA
                     GEDERRDISLLDELIRREKVNIAFFPPSLLGMFADLDFPSFKTLLFGAEAIGEKLFNRL
                     KQQPYRLMNVYGPTENTVLSTIRIVGKDTSYDDIGYPLKGTVCYVLSENLQQTTLGATG
                     ELCLGGPQVSLGYIGSVQLNEKSFISYDGERLYRTGDLVQQQPDGSIRFIGRKDTQVKI
                     R"
     aSModule        33..1556
                     /complete
                     /domains="nrpspksdomains_ctg318_1_AMP-binding.1"
                     /domains="nrpspksdomains_ctg318_1_PP-binding.1"
                     /locus_tags="ctg318_1"
                     /monomer_pairings="X -> X"
                     /starter_module
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       81..122
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg318_1_0001"
                     /evalue="3.30E-03"
                     /label="NRPS-A_a2"
                     /locus_tag="ctg318_1"
                     /protein_end="40"
                     /protein_start="26"
                     /score="11.1"
                     /tool="antismash"
                     /translation="LAIFRLGATYLPID"
     CDS_motif       303..359
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg318_1_0002"
                     /evalue="1.30E-08"
                     /label="NRPS-A_a3"
                     /locus_tag="ctg318_1"
                     /protein_end="119"
                     /protein_start="100"
                     /score="26.9"
                     /tool="antismash"
                     /translation="AYIIYTSGTTGNPKGVRIS"
     CDS_motif       861..947
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg318_1_0003"
                     /evalue="1.10E-08"
                     /label="NRPS-A_a6"
                     /locus_tag="ctg318_1"
                     /protein_end="315"
                     /protein_start="286"
                     /score="27.4"
                     /tool="antismash"
                     /translation="LGATGELCLGGPQVSLGYIGSVQLNEKSF"
     CDS_motif       1020..1082
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg318_1_0004"
                     /evalue="1.40E-11"
                     /label="NRPS-A_a8"
                     /locus_tag="ctg318_1"
                     /protein_end="360"
                     /protein_start="339"
                     /score="36.3"
                     /tool="antismash"
                     /translation="FIGRKDTQVKIRGFRIELTEI"
     aSDomain        1380..1556
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg318_1_PP-binding.1"
                     /evalue="2.50E-10"
                     /label="ctg318_1_PP-binding.1"
                     /locus_tag="ctg318_1"
                     /protein_end="518"
                     /protein_start="459"
                     /score="32.7"
                     /tool="antismash"
                     /translation="LCGILKEMLGLPQVSVEADLIDDLGLTSLDMLRLVTEANKKGCPI
                     NVSAVYTARNLRRL"
     CDS             2287..3180
                     /locus_tag="ctg318_2"
                     /transl_table=11
                     /translation="MQTENFTLGKKELLILLGLTLVLPFPINWALIELNPLTLMAGADD
                     VPTWIGFGGSYIGGIIGGIISIMILNKTLQQTGVLHHDLKLLQLDTIIYTQQQDWFTGF
                     KQELAENLKSIDLYVLNTVVSSISMKNYAYAKEVLTEINKGLEYQMVAASFSFTSTHLS
                     SEEKKYMNLVRRVQTEYSSFIKDILYYIPLAETISSRKKLNYDQLMDYTLSQYDYLQGQ
                     EGESTASGAIIPRVMEIDPSDDIRKELERIMEERLTGRTYLYHLKSDLAEATHQLIIYE
                     ENRINSILHKPEREMN"
     CDS             3411..3755
                     /locus_tag="ctg318_3"
                     /transl_table=11
                     /translation="MGKNRNHYSFFLYFVFIIFVLLGCRPVRVQMPDGMYGRWKSSAGR
                     PDITLGTDSIGSFAIVHHRIYDGKICPVRYPLHLNSPTKGYIRAEGCILFYYDSLKCVL
                     YFSPGGDYTQ"
     CDS             3796..4197
                     /locus_tag="ctg318_4"
                     /transl_table=11
                     /translation="MKENSIKPYCYCGESESSLVDNAIFVYFGDEYRRVLLDEILWLEA
                     SGSYCVLCMENGAEITVSYPLDRIFNNDLPRGKFQRIHRSYAINVFKVTGFAGNYVHIG
                     KKMLPVSESHKKNFLACFHKIYSKRALGK"
     CDS             4331..4660
                     /locus_tag="ctg318_5"
                     /transl_table=11
                     /translation="MAVDKTPSQVATSALQAIPFGSIIGGPLKACVEAQALAAKTTWEF
                     IQNVGINVNPETGEKTAVNVSFSFIQGGRLVQLNIPLLTIVPIPYIAIREVDINFKANI
                     SASSST"
ORIGIN
        1 cggtaactga tccgtccgga cttcggaata tctgtatcgg agtttgtatg gaacgaaaca
       61 aaattttagt acctgccatt ctggctattt tccggttagg ggcaacttat ttaccgatag
      121 atccctcgct gccggacaat cgtaaacggt atatggctga aaatgcggat atggttttgt
      181 tgttgaccga ttcatcgaat gaagtaggtg gaattccgtc cgtccgccaa ctttacctga
      241 atggggagca actatccgaa ccggttgttg gtgactatac tgaagttctt cccgatgatt
      301 gcgcctatat tatatatact tccggaacaa caggcaatcc caaaggtgta cgtattagtt
      361 atcggaatct ggatacattt acgaggaatc tggtagataa gaaattgtat catttgtctg
      421 atccggcaaa caggtatctg gcgtttgcga gtatcagttt tgatgcttcc atattagaac
      481 tgatgatgtg tattccggtc ggaggaacat tgatcctggc cggtgaggac gaacgcagag
      541 atatttcttt actagacgaa ctgatcaggc gcgagaaggt gaatattgct tttttccctc
      601 cttcgttgct gggcatgttt gccgaccttg actttccatc ctttaagact ctgctctttg
      661 gtgcggaggc tattggtgaa aagttattta acaggctgaa acagcagcct taccggttga
      721 tgaatgtata tggaccgaca gagaataccg tactcagtac catacggatt gtaggcaaag
      781 atacgtcgta tgacgatatt ggctatccgc tcaagggaac tgtctgttat gttttgtctg
      841 aaaacctcca acagacaact cttggggcta caggagaact ttgcttggga ggacctcagg
      901 tttcgctggg atatattggg agtgttcagc tgaatgaaaa atcattcatc tcgtacgatg
      961 gagaacgatt gtacaggaca ggtgacctgg tacagcagca accggacggt tcaatacggt
     1021 ttatcgggcg aaaagatact caggtcaaaa tacgtggctt tcgtatcgaa ttgactgaaa
     1081 tagcagaacg attgaataga gatccggacg tggagagagc ccacgtagta gttgttgagc
     1141 ggaatgggcg tcaattattg ggagcttatt tgcaaccctc agtctccggt aactttcatc
     1201 cggaagaggt caaagagcgt ttgcgtgcag aacttcctta ctacatgata cccaatttat
     1261 ggcaggtggt agatcatttt cagcgtacta taaatgataa gattgatgtc cgggcgctcc
     1321 cggcttttac ttcattggag ttgaagtatg ttcctcctgt tcatccgggg gaggttatct
     1381 tatgtggaat tttgaaggaa atgttaggtt tgcctcaagt cagtgttgag gccgatttga
     1441 ttgatgatct gggattaact tcgctggata tgttgaggct tgttaccgag gccaataaaa
     1501 aaggatgtcc catcaacgta tctgcagttt atactgcccg taatctgcgc cgattattgc
     1561 tcgttccgcg gcaagaacct atctattggt acaggcagca aaacctgaag aaacccgtaa
     1621 tcattctggt ttgtggatct gcctatttta atcatttgta ctttaatttg gccgaccgcc
     1681 tttatcccaa atatgacttt ctagttgtag atgctatcta cgatcatttt aataaagtgg
     1741 ccacggatat tccggaactg ttggaatatt atgtccggac ggttcagcca atgatccggg
     1801 agcgtaccgt ctatgcgctt accggctttt gtatgggagc tgaactggct gtcggcctgg
     1861 ccgaaatgtt acatcgctcc atggggataa tgccaaaagt ttttgctctg gatggacagg
     1921 cttggcaaaa tccggctctc tgtcaaaatt atcctttgtt ggtatttccc ggagataccg
     1981 atgaaatggt acgtgaacgg aacgaaatca taaataatta ttttcgaacc actcctaatc
     2041 tgatttatca gggagaggtt attgttttgc tgtccggatt gttccatcaa caggcgggat
     2101 tgtctcctga agagtcgtgg acggaggaaa gttatcgtat attccggaca gaatatgaca
     2161 attgcgaaag attatggaat aaatattatc cgaacgctcc tgttttgcga ttgccgacag
     2221 atcattggca ctttttagaa ggggaatcat tggaacaatt aataactgtg tttttgaagt
     2281 agatttatgc agactgaaaa cttcacttta ggtaagaaag agcttcttat tttgcttggc
     2341 ttgactcttg tactgccttt tccaatcaat tgggcattaa tcgaactgaa tccgttgact
     2401 ctgatggcgg gtgcagacga tgtgcccacc tggattggtt tcggcggcag ttatattgga
     2461 ggaatcatcg gagggatcat ctcaattatg attctgaaca agacacttca gcagacaggt
     2521 gtacttcatc acgatttgaa actcctgcag ttagatacca taatttatac tcagcaacaa
     2581 gattggttta ccggtttcaa acaagaactg gcagagaatc tcaaatctat tgatttgtat
     2641 gtgttgaata cggttgtttc gtctatatcc atgaaaaact atgcatatgc caaagaggtg
     2701 ttgacagaaa tcaataaagg gctcgaatat cagatggttg ccgcatcctt ttctttcact
     2761 tctacgcatt tatcatccga agaaaaaaag tatatgaatc tggtacgccg cgtacagact
     2821 gaatatagct cttttatcaa ggatattctt tactatattc ctttggcaga aacgatatct
     2881 tccaggaaaa aactaaacta tgatcagctg atggactata ctttgtccca atatgattat
     2941 ttgcaaggtc aggaagggga gtctacagct tcgggagcca tcataccgcg tgttatggaa
     3001 attgatccat ctgatgatat acggaaagaa ctagaacgga taatggaaga aagattaacc
     3061 gggcgtacct atttgtatca cctgaagtca gatcttgcag aggctacgca tcaattaatt
     3121 atttatgaag agaaccgtat aaactctatt ctgcataaac ctgagagaga aatgaattga
     3181 catatattaa tataatatgg tattttttta tttcagtatt aaaaatgaat ttatatttgt
     3241 ttttatttgg atgaaaagtt actttaaact tgatttatct tttatatagg aatagtttta
     3301 gaaaaaataa tccggtattc ggaaaaaaaa gagatctagt cagaatgtaa aatttccata
     3361 gattaataaa atcctatttt tgcactaaat gaaatttaaa agttttatat atgggtaaaa
     3421 ataggaatca ttacagcttt tttttgtatt ttgtctttat catatttgtg cttttgggtt
     3481 gtcgacctgt ccgggtacag atgccggacg gaatgtatgg aagatggaaa tcttctgcag
     3541 gccgtccgga tattacatta gggacagaca gcatagggag cttcgctata gttcaccacc
     3601 gtatttatga cggaaaaatt tgtcctgtcc gttatccgct tcatcttaat tcacctacta
     3661 aagggtatat ccgtgcagaa ggttgtatcc tgttttatta tgacagtttg aaatgtgttt
     3721 tatacttctc tcccggaggt gattatacac aataattaca tgcaaacact tcagttaact
     3781 aacaataaat aatttatgaa agagaattca atcaaaccgt attgttattg tggtgagtca
     3841 gaaagctcat tggtcgataa tgctattttt gtttattttg gtgatgaata cagaagagta
     3901 cttctggatg aaatcttatg gctggaagca tccggcagtt attgtgtact ctgtatggag
     3961 aacggtgcag agataacagt cagctatcct ttggatcgga tcttcaataa tgaccttcct
     4021 cgcggcaagt ttcagagaat tcatcgttct tacgctatca atgtgttcaa ggtgaccgga
     4081 tttgcaggta actatgtaca tataggaaag aagatgttgc cggtcagtga atctcacaaa
     4141 aagaattttt tagcttgttt ccataaaatt tactcaaagc gcgcattggg aaaataatgg
     4201 aggtaactaa aaagaaaacc agtttcgttt aaaattaaaa atttactacg caagggatgt
     4261 gcactacctt tgcatcgtaa gcttacaaaa gagaaaaaca attaagtaac aatttaaaaa
     4321 aacaattatt atggcagttg acaaaacacc gtcgcaggtt gcaaccagtg cgttgcaggc
     4381 gattccgttc ggttctatta ttggtggtcc gttgaaagca tgtgtggaag cacaggcttt
     4441 ggcagcaaaa acaacttggg aatttattca gaatgtaggt ataaatgtta atcccgaaac
     4501 cggtgagaag acagcagtca atgtttcttt ctctttcatt caaggcggac gtttggtcca
     4561 gttgaatatt ccgttgttga ccattgttcc tatcccttat attgcaatcc gtgaagtgga
     4621 tattaatttt aaggctaata tcagtgcttc ctcttcaaca a
//
