LOCUS       gnlProkkaADHMCKEM_33   12326 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|ADHMCKEM_33.
ACCESSION   gnlProkkaADHMCKEM_33
VERSION     gnlProkkaADHMCKEM_33
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-18 00:20:22
            Original ID  :: gnl|Prokka|ADHMCKEM_33
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 12364
            Orig. end    :: 24690
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12326
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[10000:10354]"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10354
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..12326
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..12326
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             complement(196..1641)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg33_15"
                     /sec_met_domain="Polysacc_synt (E-value: 3.9e-42, bitscore:
                     135.6, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRTSIKKNFLYNATLNVVNVLFPIITIPYVSRILGVEQIGVFSFV
                     VTIVSYFSLFAALGMPLYGTREIAKVMGDNLKLNKLFNELFSINVISSIFFTVVFCISI
                     NVIPIFIENRTYLFISGISLYFCALNIDWFYSGTENFKLITFRSIVVKLLMIISLFLFV
                     RTKDDLSIYVLLNALSLLGNQIWNVLALRYTGFNIKFTVHSLRKHLKSLCILLFSAIAM
                     QIYLMIDTLMLGFMSTYTEVGLYSSAIKSIRIVMPVTIALSVVLLPRLSYLAENGSKED
                     ATTLLNKAFDVIMLFAIPLAFFFFFISDKFVPFFFGVGYDGAIIPMKICSFLILVSNMS
                     YFASVQILAMYSFEKEFLLSTIAGMLFNIVGNFCLISTYGAIGASIASLIGELAVTFVS
                     FYFVYRNGLYKLRWSYLFKCVFSGISFFMIYRFMIPAGLTPLCWLIVFSLLSWCCYFLI
                     QLLVFKNTYCLMIIKTFQYNMLK"
     CDS             complement(1642..2190)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) dTDP_sugar_isom"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg33_16"
                     /sec_met_domain="dTDP_sugar_isom (E-value: 1e-74, bitscore:
                     240.9, seeds: 19, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNIIKTAIEGLVILEPQLFKDDRGYFFESFNQREFEEKVCKTTFV
                     QDNESKSSYGVIRGLHFQKPPFAQSKLVRVIKGAVLDVAVDIRKGSPTFGKHVSVELTE
                     DNHRQFFIPRGFAHGFSVLSEEVIFQYKCDNFYHPEAEGAIAWNDPDLEIEWRIGEDEI
                     TLSKKDCNHLCLRELCVYI"
     CDS             complement(2206..3093)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064:glucose-1-phosphate
                     adenylyl/thymidylyltransferase (Score: 279.7; E-value:
                     4.3e-85)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg33_17"
                     /sec_met_domain="NTP_transf_3 (E-value: 5.2e-13, bitscore:
                     40.6, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKGIVLAGGSGTRLYPITKGVSKQLLPIFDKPMIYYPISVLMLAG
                     IREILIISTPDDLPGFQRLLGDGSDFGVRFEYAEQPSPDGLAQAFIIGEKFIGDDSVCL
                     VLGDNIFYGQGFTRMLNEAVRIAESESKATVFGYWVSDPERYGVAEFDENGNVFSIEEK
                     PQKPKSNYAVVGLYFYPNKVVEVAKSIRPSSRGELEITTVNQNFLSDKELRVQLLGRGF
                     AWLDTGTHDSLSEASTFIEVIEKRQGLKVACLEGIALRKGWISPEKMKALAQPMLKNQY
                     GQYLLKVIDELCVK"
     CDS             complement(3096..3488)
                     /locus_tag="ctg33_18"
                     /transl_table=11
                     /translation="MKNSLCNSVSSVVKKLLEYGEDGTPVYVNELTALNQELRNLCADL
                     LLQKGESPEEEAEILVTLFKGYDTMLFNFSSENEQVIQELLDRSMTVLEKLPASVLKCQ
                     LLLECFEQTGDEELIREAKKNIERVI"
     CDS             complement(3671..4189)
                     /locus_tag="ctg33_19"
                     /transl_table=11
                     /translation="METTDSDKHWYVVLTRTNSERKVRDYFQLQEVDTFLPVQNRVIER
                     EGKRIERERLLLPRMVFVHISRQEMAAVRSTLNVYDFLRDRSTGAPTCIPDAQMADFRY
                     MLDYSQDQVILTGESIPKGTRVVVAKGDLQGLRGELVRYNNKYHILVRIDMFGSAMVTI
                     PASYVRKEK"
     CDS             complement(4570..4755)
                     /locus_tag="ctg33_20"
                     /transl_table=11
                     /translation="MLTSYSSLIKILLFDNQLLIFWMHSVVKFFSYVQDVRSCLFIKLP
                     LRLSIACLSTYFHILL"
     CDS             complement(4903..5454)
                     /NRPS_PKS="Domain: oMT (22-123). E-value: 6.9e-16. Score:
                     49.1. Matches aSDomain: nrpspksdomains_ctg33_21_oMT.1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089:methyltransferase (Score: 102.3; E-value: 5e-31)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg33_21"
                     /transl_table=11
                     /translation="MNTGHASLAQWGMSCLQWQPEWSVLDIGCGGGANLLQILQRCPQG
                     KAYGIDISPESVTFARKKNKKYLGTRCFIEQGGVHRLPYPDYAFDAVTAFETVYFWGNL
                     QHAFTEVARVLKPGGSFLICCEISDPANKAWTGLVEGMEIHSCDELKAILSKSGFTDTA
                     IFRTKKEELCLVSHRQTVRL"
     aSDomain        complement(5086..5388)
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg33_21_oMT.1"
                     /domain_subtypes="oMT"
                     /evalue="6.90E-16"
                     /label="ctg33_21_oMT.1"
                     /locus_tag="ctg33_21"
                     /protein_end="123"
                     /protein_start="22"
                     /score="49.1"
                     /tool="antismash"
                     /translation="SVLDIGCGGGANLLQILQRCPQGKAYGIDISPESVTFARKKNKKY
                     LGTRCFIEQGGVHRLPYPDYAFDAVTAFETVYFWGNLQHAFTEVARVLKPGGSFLI"
     CDS             complement(5619..5747)
                     /locus_tag="ctg33_22"
                     /transl_table=11
                     /translation="MNLLCCNVYVVFMKRKRKEHRTSGHLFVIILTGSRCIPANIF"
     CDS             complement(6179..6472)
                     /locus_tag="ctg33_23"
                     /transl_table=11
                     /translation="MAMSSAVGCGSRLSAYPNKASRGRATPPIRAGIQNSLMFKVSMTY
                     KPADLAVPELMTILTPSKLARMSVIRLPSIKLKMIPHIHPSESPFRNMAPIL"
     CDS             6638..6919
                     /locus_tag="ctg33_24"
                     /transl_table=11
                     /translation="MDVCTGRQRSNPHYSDNFRINGVRQKQLESTVDITGIDHCQHGSD
                     GSRFVWLRTIAAERHRLAIHPEPVSLSGFSHFPDYLLRPFYRLLQNSR"
     CDS             6921..7184
                     /locus_tag="ctg33_25"
                     /transl_table=11
                     /translation="MGFFIAMNDFLGYTGTVIVLAVKEFFSPDINWTAFYNLMAGYVGI
                     ICFVAFVCSFIYLHQRYRRENYGKTGVFRKKEEEKEVPDFVY"
     CDS             complement(7210..7593)
                     /locus_tag="ctg33_26"
                     /transl_table=11
                     /translation="MIHRQGRRYKLCAYFAELHIIHHLYQLLVGLAVGRQFPFRVKQIG
                     FDLVFLFRQHSGYGKGISAIVARSGKYRDGSCDVPAFGDGFGQCLCGPLHQVDRCNRFM
                     FYGVSIQFLDAATWKNLHGELSF"
     CDS             7600..8739
                     /locus_tag="ctg33_27"
                     /transl_table=11
                     /translation="MDGLFGSGLNKPLSGGFAAVVKYINASPATVVAIDIPSGLMGEEN
                     TFNVKANIIRAQLTLSLQLPKLAFLFAENSEFVGEWKLLDINLSREAIEETESNYALLE
                     AEEIHALIKPRNTFSHKGNFGHALLIAGSYGMAGASILAARACMRSGVGLLTVHAPIRN
                     NDILQISVPEAIIESDASDTYFACPTDTDDYQAVGIGPGIGRSEETEAALLEQLSGCQT
                     PLVLDADALNILANHRHALTTLPKGSILTPHPKELERMVGKCQNSYERLMKACELARTA
                     KVHIILKGAYSAIITPSGKCYFNSTGNPGMATAGSGDVLTGVVLALLAQGYPAEEAAKI
                     GTYVHGLAGDFARKKQGVISMTAGDIISNLPLAWRLVSE"
     CDS             8812..9867
                     /locus_tag="ctg33_28"
                     /transl_table=11
                     /translation="MKKLIILTGLLLSTSAYAQTEVTAGVTRGKDYGVTYALPKTAINI
                     EVKVNKVTYTPGEFSKYADRYLRLTDVSGEPQEYWELVSVKAKSVGIPDSEHTYFVKLK
                     DKTVAPLIELTEDGIVKSINVPLSPKKSAPMQPATTQKKKINPRDFLTEEILMAGSTAK
                     MAELVAKEIYNIRESKNALVRGQADNMPKDGEQLKIMLANLEEQEAAMTEMFSGTLNKD
                     EKIFNIRLTPDKEMDNEVAFRFSKKLGIVANNDLAGEPVYITLKNLKTVNVPEDDGKKK
                     VDGIAYNVPGKAQVTLTEGKKQWFNGELPVTQFGTIEYLAPALFNKKSTVQVTFNPDTG
                     GLIKVDREEGE"
     CDS             complement(10001..10354)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg33_29"
                     /sec_met_domain="PF05402 (E-value: 4.6e-17, bitscore: 53.2,
                     seeds: 461, tool: rule-based-clusters)"
                     /sec_met_domain="PqqD_RRE (E-value: 6.5e-10, bitscore:
                     29.8, seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MADAKEKINLLDVIPFRSENITAEKGSDGTVTIAFPRFKYEWMRR
                     FLLPKGMSADIHVRLEDHGTAVWELIDGKRTVRRIIEELAEHFNYEENYESRITAYITQ
                     LQKDGFVKLVIEN"
     CDS             complement(10361..11749)
                     /gene_functions="transport (smcogs) SMCOG1106:major
                     facilitator transporter (Score: 97.1; E-value: 1.4e-29)"
                     /gene_kind="transport"
                     /locus_tag="ctg33_30"
                     /transl_table=11
                     /translation="MTEQLKNKLSDSKTLRWSVLALVAFTMLCGYFLTDVMSPLKPMLE
                     KELLWDSLDYGFFTSAYGWFNVFLLMLIFGGIILDKMGVRFTGMGACILMVLGCGLKYY
                     AISTTFPEGALIMGFKTQVFLAALGYAIFGVGVEIAGITVSKIIVKWFKGKEMALAMGL
                     EMATARIGTTLAMVLTVPIADYFGYTDESGSFHTNIPMPILLCLIMLCIGTIAFFIYTF
                     YDKKLDASLDAQGEEPEEPFRMKDVMLIVTNKGFWLIALLCVLFYSAVFPFIKYATDLM
                     VQKYNVDPKLAGNIPGLLPIGTIFLTPLFGTLYDRIGKGATLMIIGAVMLIGVHTLFAL
                     PILNVWWFATVIMIVLGIAFSLVPSAMWPSVPKIIPEKQLGTAYALIFWVQNWGLMGVP
                     LLIGWVLNTYCKGPVVDGAQTYDYTLPMAIFACFGVLALIVALMLKAEDKKKGYGLQEA
                     NIKK"
     CDS             complement(11920..12324)
                     /locus_tag="ctg33_31"
                     /transl_table=11
                     /translation="MTLNQNNKMYLLLVILMVIAAILMCFIVLIQNSKGGGLASGFSSS
                     NQIMGVRKTTDFLEKATWGLAAFMVVMSIATAYVVPTSSSKTQDVIMEQAQQEEQTNPY
                     NLPVGTTAPKTDAAAPVEAPATETPATPAN"
ORIGIN
        1 aattatcacc aattgtcaca tatttacccc catttacaaa taatggagga caaatcctta
       61 tatgtttccc cgtggattta aaccagtgca tcactatttt cgaaaacaaa taatatttaa
      121 ttcttttaca ttgcccatat cttctttccg tgaaaaaaga ggcaatgaca aaaccaagtt
      181 tactcaataa gcatctcatt ttaacatatt atattggaaa gttttaatta tcattaagca
      241 ataagtattt ttaaacacca acaattgaat caaaaaataa cagcaccaag acaataacga
      301 aaaaactatt aaccaacaca atggcgttaa acctgcagga atcataaatc tataaatcat
      361 aaaaaaagag attccactaa acacgcattt aaaaagatag ctccatctca acttatacag
      421 gccatttcga taaacaaaat agaaagaaac aaatgtgaca gccaactctc ctattagaga
      481 tgcaatagac gcaccaatag caccatatgt ggaaattaaa caaaaatttc cgactatatt
      541 gaataacata ccagctatag tagataaaag aaattctttt tcaaaagagt acatagccaa
      601 aatttgaaca gaagcaaaat atgacatatt actcactaaa attaaaaatg agcatatctt
      661 catagggata atagcaccat cgtatcctac tccgaaaaaa aatgggacaa atttgtctga
      721 tataaagaaa aagaaaaaag ccagaggtat tgcgaataac ataattacat caaaagcttt
      781 atttaggaga gttgtagcat cttcctttga tccattttcc gccaaataag aaagtctggg
      841 taataagaca acgctcaaag ctatagttac aggcatcaca atccgaattg atttaatggc
      901 agaagaatat agtcccacct ctgtataggt agacataaat cctaacatta aagtatctat
      961 cattaaataa atctgcatag caatagctga gaaaagtaat atacacaaag atttaagatg
     1021 ttttcttaat gaatgaacag taaacttgat attaaaccca gtatacctca atgccaacac
     1081 attccatatt tgattcccta aaagcgacaa agcatttaat aaaacataaa ttgacaaatc
     1141 atctttggtc cttacaaaca aaaacaatga tataatcatt aataatttaa ctactataga
     1201 cctaaaagtt atcaacttaa agttttcagt accagagtaa aaccaatcta tatttaatgc
     1261 acaaaagtac aatgatattc ctgagataaa tagataagtc ctattttcta taaatatggg
     1321 aataacattt atagagatac aaaaaacaac agtaaaaaaa atagaagata taacatttat
     1381 agaaaataat tcattaaata atttattaag tttcaaatta tctcccataa ctttagcaat
     1441 ctcacgagtt ccatataaag gcattcccaa agctgcaaac aaagaaaaat agctaacaat
     1501 agtaactaca aaagaaaaca cacctatttg ttctactcct aaaatacgac tcacatatgg
     1561 tattgttatt ataggaaata gaacattgac aacattcaaa gttgcattat ataagaaatt
     1621 ttttttaatt gaggttctca tttaaatata aacacacaat tctcttaaac aaagatgatt
     1681 acaatccttc tttgaaagtg taatttcatc ttcgcctatt ctccattcga tttctaaatc
     1741 cggatcattc caagcaatag ctccttctgc ttccggatga taaaagttat cacacttata
     1801 ctgaaaaatt acttcttcgc tcagcacact aaaaccatgc gcaaagccac gtgggataaa
     1861 gaactgacgg tggttatctt ctgtaagctc tacagataca tgttttccaa atgtaggtga
     1921 acccttacga atatcaacag ctacatcaag aacagctccc ttaatcaccc gcactaactt
     1981 gctctgggca aaagggggtt tctgaaaatg taaaccacga ataacgccat agcttgactt
     2041 agattcatta tcctgtacaa aagtagtttt acagactttt tcttcgaatt ctctctgatt
     2101 gaaagattca aagaaatacc cacgatcatc tttgaagagt tgtggctcaa ggatcacaag
     2161 tccttcaata gctgttttta ttatattcat tggaagaaag tagttttatt ttacacacaa
     2221 ttcatctata accttcaaca gatattgtcc atattgattc ttaagcattg gctgtgccaa
     2281 tgctttcatc ttttccggag aaatccagcc ttttcttaaa gcaatcccct ctaaacacgc
     2341 aacttttaag ccttgacgct tctcaataac ttcaataaaa gtacttgctt cggataaaga
     2401 atcatgtgta cctgtatcaa gccaagcaaa tccccgacct aataattgaa ccctcaactc
     2461 cttatctgat aaaaagttct gattgacagt cgttatttct aactcaccac gagaagaggg
     2521 tctaatactc ttagcgactt caaccacctt attaggataa aaatataatc ctacaacggc
     2581 ataattagat tttggcttct gaggtttttc ctctatgctg aaaacattcc cgttctcatc
     2641 aaactccgct acaccgtagc gttcgggatc acttacccaa tagccaaaaa cggttgcttt
     2701 actttctgat tctgcaatac gaacagcctc atttaacatt cgcgtaaacc cttggccata
     2761 aaaaatatta tcacctaaaa ccaaacagac agaatcatcc cctataaatt tttctcctat
     2821 gataaaagct tgtgccaaac catcaggtga aggttgctct gcatactcaa acctcacccc
     2881 aaaatcagat ccgtcaccca ataaacgttg aaatcccggc aagtcatctg gagtagaaat
     2941 aatgagaatt tcccgtatac ctgccaacat tagtacagaa ataggataat aaatcatagg
     3001 tttatcaaag ataggaagca actgcttact cactccttta gttataggat ataaccgtgt
     3061 ccccgaccca cctgctaaaa caataccttt cattgtcaga taactctctc tatgtttttc
     3121 ttagcttctc ttatcagttc ctcatctccc gtctgctcaa agcactccag cagcaactga
     3181 catttcaata cagaggctgg tagtttttct aaaacagtca ttgaacgatc caataattct
     3241 tgaataacct gttcattctc agaggagaaa ttaaacagca tggtatcgta acctttgaac
     3301 aaagtaacaa gtatttccgc ctcttcttcg ggagattctc ctttctgaag aagaagatcg
     3361 gcacacaagt tacggagttc ttgatttaac gcagtaagtt cattcacata gacaggagta
     3421 ccgtcctcgc catactccaa gagtttcttc actacggagg acacagaatt acacagagaa
     3481 tttttcattt taaaaaggaa tgaattatga ttcgtcgatt cttttcggtt tttatttgta
     3541 tagaagagta ataatatcca atagaattat atctaacgac gtaacggggc attacatata
     3601 ttgttatcac ccgttacata tattgttatc gccattacat ataatggtat tttctttaca
     3661 tatatacttt ttatttctct ttccggacgt agctagccgg aattgtaacc atagcgctac
     3721 cgaacatatc gatacgtact aaaatatgat atttattatt atagcggacc aattctcccc
     3781 gcaagccttg taaatcgccc ttggcaacta ctacacgagt acctttggga atggactctc
     3841 ctgtcaggat cacctgatcc tgggagtaat cgagcatata gcgaaaatca gccatttgcg
     3901 catcagggat acaggtagga gccccggtgg aacgatcacg aaggaaatcg tatacattca
     3961 gtgtacttcg gacggcagcc atttcctgac gggagatatg aacgaaaacc atacggggca
     4021 acaaaaggcg ctcacgctca atgcgttttc cttcacgctc tatgacacgg ttttgtacag
     4081 gaagaaaggt atctacctcc tgcaattgaa aataatcccg aactttacgt tctgagttag
     4141 ttcgtgtcag tacgacatac caatgtttat cgctatctgt tgtctccaag actacgttcg
     4201 taagaaaaag tttcagtaat gactaaggat gaaaatttgt taaaaacagg aatattcaaa
     4261 aaacacgcct tattttcagc aatttacaaa ttaagtttta tgataatcgg gtacagaaaa
     4321 agtattcgca ccggatttga atactatccg atacgttgaa ttattttatt ttaaacatat
     4381 atcggacata aagaaaagta tatttgtccg cctatatatt tacgggtgca aaggtaaaac
     4441 cttcttttga gtctccaaaa cttttcacag gttattttca tcataggaag ttatatgact
     4501 gaatatcaaa gatataattt atctctttgc aaataaggaa agcagcaata tacataatac
     4561 taatgtggct tataaaagaa tgtggaaata agtggagagg caggctatgg agagtcttaa
     4621 cggtaacttg ataaacagac aactacgcac atcttgaacg taagagaaga attttacgac
     4681 agaatgcatc cagaatataa gcaattgatt atcaaacaat aatatcttaa taagagaact
     4741 gtaggaagtt aacattaaca gtacgttaat attaacttcg taattgcaag atattaattc
     4801 tttagagata cgaagttaat aagctattga caaggaggga aagcactttt acgggcatta
     4861 acattgttaa cgtattcgtt ggtaagagcg tcccggcatt ggttacaacc gcacagtttg
     4921 ccgatggctt accaggcaca gttcttcttt cttcgtccgg aatatggccg tatcggtaaa
     4981 accacttttg gaaagaatcg ccttcagttc atcacaggaa tgaatctcca tcccttcaac
     5041 aagtcccgtc caagccttat tggcaggatc gcttatctca caacagataa gaaacgatcc
     5101 accgggcttt aacacacgcg ccacttccgt aaaagcatgc tgcaggttac cccagaagta
     5161 gacagtctcg aaagcagtga ccgcatcgaa cgcataatca ggatagggaa gtcggtggac
     5221 tcctccctgc tcgataaagc agcgtgtacc gagatacttt ttattttttt tacgcgcaaa
     5281 ggtgacactc tccggtgaaa tatctatgcc atacgctttc ccttgcgggc aacgttgcaa
     5341 tatctgtagc aaattggcac caccaccgca accgatgtcg agtacactcc attccggttg
     5401 ccattgcaag catgacattc cccattgcgc caatgatgca tgtcctgtat tcatccccca
     5461 aagtatcatt cttccgaaaa aaccttcagg cttccggaaa ttctgtaaga tcttgcttac
     5521 aaagcctctc ttattcattt gtctgctgat ttaatatttc aggcaaaagt acagtttctg
     5581 cccaaacagg caatacccag aaatagggaa tttatttcct aaaagatatt tgcaggtatg
     5641 catctgcttc ccgttaaaat tatgacgaac agatgcccgg aagtgcgatg ctcttttcgt
     5701 ttccgtttca taaatactac ataaacatta caacataaca gattcattat caatatctat
     5761 taataataaa cattcatata ttcagtaaca ggtctgtaac actaccctcc tatttttgca
     5821 ccggaaaaca acaagcagat gttatgaaca atgtacagca agtaaaaact tattcgcaga
     5881 gaaaaatttc tgatttcctt ttcattcttt gggcaggcgg agcagcgctg ctctcctatt
     5941 cattggtata tgcactgaga aagccttata cagcagccgg atttgacgga cttgaagcgt
     6001 ttggaatgga ctacaaagtg gtagttacca tcgcgcaaat attaggatat gtactttcta
     6061 aattcatcgg aattaaatta atctccgaat taaaacggga aaaccggatg aagtttattc
     6121 tgatctccat aattctggct gaagcttcgt taatattgtt cggactgttg cccgcacctt
     6181 ataatatagg agccatgttt ctgaacggac tttcactggg atgtatgtgg ggaatcattt
     6241 ttagctttat cgagggaaga cgaatgacgg acattcttgc cagcttactc ggagtcagta
     6301 tggtcatcag ctcgggtacc gccaagtcgg ccggtttgta tgtcatggac actttgaaca
     6361 tcagcgaatt ctggatgcct gccctgatag gcggagttgc ccttcctcta cttgccttgt
     6421 tgggatatgc actcaaccgg cttccacagc caacagccga agacattgcc atgaaatcga
     6481 aacgggaaac actgaacggc aagcaacgat ggaagctatt taagaatttc atgcctttcc
     6541 tcactctgct ctttatagcc aatgtggtac tgactatctt gagagatata aaggaggact
     6601 tcctggtaaa aattatcgat gtctctcaat actcttcgtg gatgtttgca caggtagaca
     6661 gcgtagtaac cctcattatt ctgataattt tcggattaat ggtgttcgtc agaagcaact
     6721 tgaaagcact gtcgatatta ctgggattga tcattgccag catggtagtg atggcagtcg
     6781 tttcgtttgg ttacgaacaa ttgcagctga acgccatcgt ctggctattc atccagagcc
     6841 tgtgtctcta tctggctttt ctcactttcc agactatctt cttcgaccgt tttatcgctt
     6901 gcttcaaaat tcgaggtaac gtgggtttct tcattgctat gaatgatttt ctgggctata
     6961 cgggaacagt catagtattg gctgtcaaag aattcttttc accggacatt aactggacag
     7021 ctttctacaa tctgatggca ggatatgtgg gaataatctg tttcgttgct tttgtatgct
     7081 ctttcatcta cctgcaccaa cgctaccgca gggagaatta cggaaagaca ggggtattca
     7141 gaaaaaaaga agaagaaaaa gaagttcccg atttcgtata ttaattgcta tctttgtggg
     7201 tcaaaaaact taaaatgaaa gttcaccatg aagatttttc caagtagcag catcaagaaa
     7261 ctggatgctt acaccataga acatgaaccg attgcatcga tcgacctgat ggagcgggcc
     7321 gcacaggcac tgaccaaagc catcaccgaa cgctgggaca tcacaactcc cgtcacggta
     7381 tttgccggac cgggcaacaa tggcggagat gcccttgccg tagcccgaat gttggcggaa
     7441 aaggaataca aggtcgaagc ctatctgttt aacccgaaag gggaactgtc tgccgactgc
     7501 cagaccaaca aggagctggt agagatgatg gataatgtga agttcagcga agtaagcaca
     7561 cagtttgtac ctcctaccct gacgatggat catctggtag tggacggact ttttggttcg
     7621 ggacttaata agccgctaag tggcggtttt gcggcagtag tgaaatatat caatgcatcg
     7681 cctgccaccg tagtcgccat cgatatcccc tcgggactga tgggagaaga gaacacattt
     7741 aatgtaaaag ccaatatcat ccgtgcccaa ttgacattga gtctgcaatt gccgaaactg
     7801 gctttcctct ttgccgaaaa ttccgaattc gtaggcgaat ggaaactgtt ggatatcaac
     7861 ctcagtcgtg aagcgattga ggagacggaa agcaattatg ccttattgga agcggaagaa
     7921 atacacgctc tgatcaaacc ccgtaacact ttctcacaca aaggaaactt tgggcatgct
     7981 ctgctgattg ccggttcgta cggcatggca ggcgcgtcga tactggcagc ccgcgcctgt
     8041 atgcgttcgg gtgtaggctt actgacagtc catgcaccta tacgcaacaa tgatatcctg
     8101 cagatttcgg ttccggaggc aattatcgaa tcggatgcca gcgataccta ctttgcctgc
     8161 cctacagata cggatgacta tcaggctgta ggaatcggtc cgggcatcgg acgctcggaa
     8221 gagaccgaag ctgcactgct tgaacaactc agtggttgcc agacacctct ggtactggat
     8281 gccgatgcac taaacatatt ggccaaccac cgccacgcac tgaccacatt gcccaaaggc
     8341 tctattctga ctccccatcc caaagaactg gaacgcatgg tgggcaaatg ccagaactca
     8401 tacgaacgac tgatgaaggc ctgtgaactg gcccgaaccg ccaaagtaca tatcatatta
     8461 aaaggagcct attcggcaat tatcaccccc tcgggcaagt gctatttcaa ctctacgggt
     8521 aatccgggta tggcaacagc cggaagcgga gatgtattga caggtgtcgt gctggctttg
     8581 ctcgcacagg gatatccggc tgaagaagct gccaaaatcg gtacttatgt acatggcctg
     8641 gcaggtgatt tcgcacgcaa aaagcaaggc gttatcagca tgacggcagg agacattatc
     8701 agtaatctgc cattggcttg gcgtctggta agcgaataaa agttaacaac ttatgatttt
     8761 ccaaataact tcattaactt tgttttttaa accagttaaa ataaaccgga aatgaaaaag
     8821 ctaattatac tgacagggct gttactctct acctcggctt atgcccagac cgaagttaca
     8881 gcgggagtta cccggggaaa agattacgga gtaacctatg cacttcctaa aacagcaatc
     8941 aatattgaag tcaaagtcaa taaagtgaca tatactccgg gagaattcag caagtatgcc
     9001 gaccgttatc tccggttgac cgatgtgtcg ggtgagcctc aggaatattg ggaactggtc
     9061 agcgtcaaag caaaatctgt cggtatcccc gatagcgaac atacctattt tgtcaagctg
     9121 aaagataaaa cagtagctcc gctaatagaa ttgaccgaag atggtatcgt aaaatcaatc
     9181 aacgtaccgc tatctcctaa aaaatcggct ccgatgcaac ccgccacgac acagaaaaag
     9241 aagataaatc cacgtgattt tctgaccgaa gagattctga tggcaggttc tacagctaaa
     9301 atggcggagt tggttgccaa agagatttat aacattcgtg aaagtaaaaa tgccctggta
     9361 cgcggacagg cagacaacat gcccaaagat ggggagcaac tgaagattat gcttgccaac
     9421 ctggaagagc aagaggctgc catgaccgaa atgttctcgg gtaccttgaa taaagacgaa
     9481 aagatattca acatccgcct cactccggat aaggaaatgg acaacgaagt agccttccgc
     9541 ttttcgaaga agctgggcat agttgctaat aacgatcttg caggagagcc ggtttatatc
     9601 acgctgaaga atctgaaaac cgtcaacgta ccggaagacg atggcaaaaa gaaggtggac
     9661 ggcattgcct ataatgtgcc cggcaaagca caagtaacac taacggaggg gaaaaagcaa
     9721 tggtttaacg gagaacttcc tgtcacacaa ttcggtacca tcgaatatct ggctccggcg
     9781 cttttcaata agaaatcgac tgttcaggtt actttcaacc cggatacagg aggcttgatc
     9841 aaggtagata gagaagaagg agaataaaac ataatcaaaa actccggccg atcttaaatg
     9901 aagtgcaccc caaaagttca tgtttaactt ttagggtgca cttcattttt aaatcagccg
     9961 gagtctcttt attatattcc aatagtatat cgtaatgcaa tcagttctca atcactaatt
    10021 tcacaaatcc gtctttctgc aactgagtga tataagccgt aatacgtgat tcgtaatttt
    10081 cttcataatt gaagtgttct gccagctctt caataatccg gcgtacggtt ctctttccgt
    10141 caatcaactc ccatacggca gtgccatgat cttccagccg gacatgaata tccgcagaca
    10201 ttcctttagg caacaagaat cgccgcatcc actcgtattt aaaccggggg aaagcaatgg
    10261 taacggtacc atcgcttccc ttttcggccg taatattttc actacggaaa ggaattacat
    10321 ccagaagatt tattttctct ttcgcgtctg ccatatactg ttattttttg atatttgctt
    10381 cctgcagtcc gtatcccttc ttcttgtctt ccgctttcaa cattaaagct acaatcagag
    10441 ccaaaacacc gaaacaagca aagatagcca taggcaaagt atagtcataa gtctgcgctc
    10501 catccacaac aggacctttg caataggtat tcaacaccca tccgatcaac agaggtaccc
    10561 ccatcaatcc ccagttctgc acccagaaaa tcaaagcata ggcagtaccc agttgtttct
    10621 ccggaataat tttcggaaca gaaggccaca tggccgaagg caccagtgaa aaagcaatac
    10681 ccagaacaat cataatcaca gtggcaaacc accatacgtt cagaatggga agcgcaaaca
    10741 aagtatgcac accaatcagc atgacggcac cgataatcat caacgtcgct cccttaccga
    10801 tacggtcata aagagtacca aacaacggag tcaggaagat ggtacctatc ggtagtaatc
    10861 ccggaatatt tccggccagc ttagggtcta cgttatactt ctgcaccatc aggtcggttg
    10921 catatttaat aaaggggaaa acagcagaat agaatagtac acacaataaa gcaatcagcc
    10981 agaagccttt attggtgaca atcagcataa cgtccttcat acggaacggt tcttccggtt
    11041 cttctccctg agcatctaaa gaagcgtcaa gtttcttatc ataaaaggta taaatgaaaa
    11101 aggcgatagt accgatgcac agcatgatca ggcacaacaa aataggcatc ggaatattgg
    11161 tatggaaact gccgctttca tccgtatagc cgaaataatc ggcaatggga acggtaagca
    11221 ccatagccaa agtggtaccg atacgtgcgg ttgccatctc aagtcccata gccaaagcca
    11281 tctctttacc tttaaaccat ttcacgataa tcttagagac agtgataccg gcgatctcta
    11341 cgccgacacc aaagatagcg tatcctaaag ccgccagaaa gacctgagtc ttgaaaccca
    11401 taatcaaagc tccctcagga aaagtagtag agatagcata atattttagt ccacaaccca
    11461 acaccatcag tatacaagct cccataccgg tgaaacgaac tcccatctta tcgagaataa
    11521 taccaccgaa aatcaacatg agcaggaata cattgaacca tccgtaagca ctggtaaaga
    11581 atccgtagtc caaactatcc cagagaagct ctttctcgag cataggcttt aaaggggaca
    11641 ttacatcagt gaggaaatag ccgcaaagca tagtaaacgc gaccagagcg agcacactcc
    11701 aacgaagtgt tttggagtca ctcaatttgt ttttcaattg ttctgtcatt gtaatattta
    11761 aactcagaaa ttagtaaaag tgttattgcg aacaaaggta actaaatctg ccttgtatgc
    11821 ctaacaaaaa gatgcatttt acggcaaaaa ataagcgaag ctgcaagttt cggtttgaaa
    11881 ttgcagcttc gcttatcgtt tcttaaaaag aatctgttgt tagtttgccg gagtagccgg
    11941 agtttctgtg gcaggtgctt caaccggagc agcagcgtct gtcttcggtg cagtagtacc
    12001 tacgggcagg ttataagggt tggtctgctc ttcctgctgt gcctgttcca taatgacatc
    12061 ttgtgtttta gaagaagaag tcggaacgac atacgcagta gcaatgctca tcacaaccat
    12121 aaatgcagct aagccccaag ttgctttttc cagaaagtct gtagttttgc gtacacccat
    12181 aatctggtta gatgatgaga accctgaagc aagaccaccg ccttttgagt tctgaatcaa
    12241 cacaatgaag cacatcagta tggctgcaat aaccattaag ataactaata ataagtacat
    12301 tttgttattt tgatttagcg ttaata
//
