GCA_948441415.1 - 4 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

gnlProkkaOPEJBGJG_1 (original name was: gnl|Prokka|OPEJBGJG_1)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1.1	NRPS,HR-T2PKS	85,619	169,591	leucomycin	Polyketide	3%

gnlProkkaOPEJBGJG_2 (original name was: gnl|Prokka|OPEJBGJG_2)

Region	Type	From	To	Most similar known cluster		Similarity
Region 2.1	ranthipeptide	217,622	239,229

gnlProkkaOPEJBGJG_6 (original name was: gnl|Prokka|OPEJBGJG_6)

Region	Type	From	To	Most similar known cluster		Similarity
Region 6.1	RRE-containing	33,905	54,168

gnlProkkaOPEJBGJG_14 (original name was: gnl|Prokka|OPEJBGJG_14)

Region	Type	From	To	Most similar known cluster		Similarity
Region 14.1	RiPP-like,cyclic-lactone-autoinducer	9,475	30,887

No secondary metabolite regions were found in these records:: gnlProkkaOPEJBGJG_3 (original name was: gnl|Prokka|OPEJBGJG_3); gnlProkkaOPEJBGJG_4 (original name was: gnl|Prokka|OPEJBGJG_4); gnlProkkaOPEJBGJG_5 (original name was: gnl|Prokka|OPEJBGJG_5); gnlProkkaOPEJBGJG_7 (original name was: gnl|Prokka|OPEJBGJG_7); gnlProkkaOPEJBGJG_8 (original name was: gnl|Prokka|OPEJBGJG_8); gnlProkkaOPEJBGJG_9 (original name was: gnl|Prokka|OPEJBGJG_9); gnlProkkaOPEJBGJG_10 (original name was: gnl|Prokka|OPEJBGJG_10); gnlProkkaOPEJBGJG_11 (original name was: gnl|Prokka|OPEJBGJG_11); gnlProkkaOPEJBGJG_12 (original name was: gnl|Prokka|OPEJBGJG_12); gnlProkkaOPEJBGJG_13 (original name was: gnl|Prokka|OPEJBGJG_13); gnlProkkaOPEJBGJG_15 (original name was: gnl|Prokka|OPEJBGJG_15); gnlProkkaOPEJBGJG_16 (original name was: gnl|Prokka|OPEJBGJG_16); gnlProkkaOPEJBGJG_17 (original name was: gnl|Prokka|OPEJBGJG_17); gnlProkkaOPEJBGJG_18 (original name was: gnl|Prokka|OPEJBGJG_18); gnlProkkaOPEJBGJG_19 (original name was: gnl|Prokka|OPEJBGJG_19); gnlProkkaOPEJBGJG_20 (original name was: gnl|Prokka|OPEJBGJG_20); gnlProkkaOPEJBGJG_21 (original name was: gnl|Prokka|OPEJBGJG_21); gnlProkkaOPEJBGJG_22 (original name was: gnl|Prokka|OPEJBGJG_22); gnlProkkaOPEJBGJG_23 (original name was: gnl|Prokka|OPEJBGJG_23); gnlProkkaOPEJBGJG_24 (original name was: gnl|Prokka|OPEJBGJG_24); gnlProkkaOPEJBGJG_25 (original name was: gnl|Prokka|OPEJBGJG_25); gnlProkkaOPEJBGJG_26 (original name was: gnl|Prokka|OPEJBGJG_26); gnlProkkaOPEJBGJG_27 (original name was: gnl|Prokka|OPEJBGJG_27); gnlProkkaOPEJBGJG_28 (original name was: gnl|Prokka|OPEJBGJG_28); gnlProkkaOPEJBGJG_29 (original name was: gnl|Prokka|OPEJBGJG_29); gnlProkkaOPEJBGJG_30 (original name was: gnl|Prokka|OPEJBGJG_30); gnlProkkaOPEJBGJG_31 (original name was: gnl|Prokka|OPEJBGJG_31); gnlProkkaOPEJBGJG_32 (original name was: gnl|Prokka|OPEJBGJG_32); gnlProkkaOPEJBGJG_33 (original name was: gnl|Prokka|OPEJBGJG_33); gnlProkkaOPEJBGJG_34 (original name was: gnl|Prokka|OPEJBGJG_34); gnlProkkaOPEJBGJG_35 (original name was: gnl|Prokka|OPEJBGJG_35); gnlProkkaOPEJBGJG_36 (original name was: gnl|Prokka|OPEJBGJG_36); gnlProkkaOPEJBGJG_37 (original name was: gnl|Prokka|OPEJBGJG_37); gnlProkkaOPEJBGJG_38 (original name was: gnl|Prokka|OPEJBGJG_38); gnlProkkaOPEJBGJG_39 (original name was: gnl|Prokka|OPEJBGJG_39); gnlProkkaOPEJBGJG_40 (original name was: gnl|Prokka|OPEJBGJG_40); gnlProkkaOPEJBGJG_41 (original name was: gnl|Prokka|OPEJBGJG_41); gnlProkkaOPEJBGJG_42 (original name was: gnl|Prokka|OPEJBGJG_42); gnlProkkaOPEJBGJG_43 (original name was: gnl|Prokka|OPEJBGJG_43)

Compact view

gnlProkkaOPEJBGJG_1 - Region 1 - HR-T2PKS,NRPS

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Location: 85,619 - 169,591 nt. (total: 83,973 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX))
HR-T2PKS: (hr-t2pks-ksa and (t2fas or APE_KS2 or ketoacyl-synt))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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resistance

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Gene details

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Gene overview

NRPS/PKS domains

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Detailed domain annotation

Selected features only

Show module domains

Similar known gene clusters from MIBiG 3.1

Module view

Legend

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 85618 - 169591:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Ile - X)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 85618 - 132950:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Ile - X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ctg1_94

Search NORINE for peptide: strict or relaxed

AMP-binding (457..845): Ile

nrpys: Ile

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DASFLGGVYK
Nearest Stachelhaus code(s):: Ile DALFMGGVYK (56% 8Å match)
Stachelhaus code match:: 80% (moderate)

AMP-binding (1479..1869): X

nrpys: Asp, Asn, Glu, Gln, Aad

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DMKNLGTVSK
Nearest Stachelhaus code(s):: Asp DMKDLGMVDK (53% 8Å match)
Stachelhaus code match:: 70% (weak)

gnlProkkaOPEJBGJG_2 - Region 1 - ranthipeptide

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Location: 217,622 - 239,229 nt. (total: 21,608 nt) Show pHMM detection rules used

Region on contig edge.

ranthipeptide: (TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085 or SPASM)) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716 or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or (YcaO or TIGR03604))))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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Gene overview

KnownClusterBlast

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Similar known gene clusters from MIBiG 3.1

No matches found.

gnlProkkaOPEJBGJG_6 - Region 1 - RRE-containing

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Location: 33,905 - 54,168 nt. (total: 20,264 nt) Show pHMM detection rules used

RRE-containing: minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE])

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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Gene overview

KnownClusterBlast

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Similar known gene clusters from MIBiG 3.1

No matches found.

gnlProkkaOPEJBGJG_14 - Region 1 - RiPP-like,cyclic-lactone-autoinducer

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Location: 9,475 - 30,887 nt. (total: 21,413 nt) Show pHMM detection rules used

Region on contig edge.

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))
cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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Gene overview

KnownClusterBlast

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Similar known gene clusters from MIBiG 3.1

No matches found.