LOCUS       c00045_gnlPro..        15566 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|KNCMLIPI_45.
ACCESSION   c00045_gnlPro..
VERSION     c00045_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-07 06:28:14
            Original ID  :: gnl|Prokka|KNCMLIPI_45
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15566
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..273
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ILVD_EDD"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg45_1"
                     /sec_met_domain="ILVD_EDD (E-value: 2.3e-32, bitscore:
                     102.2, seeds: 918, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="PTIFVSGGPMEAGNLDGRALDLIDAMIEAADDSISDEQVEKVERS
                     ACPTCGCCSGMFTANSMNCLNEAIGLALPGNGTVVATHANRTRLF"
     protocluster    1..15566
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[0:5566]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      1..5566
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..15566
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..15566
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             286..1416
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ILVD_EDD"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg45_2"
                     /sec_met_domain="ILVD_EDD (E-value: 1e-127, bitscore:
                     416.7, seeds: 918, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIVDNAFKYYRDGDDSVLPRSIATRQAFLNAMSLDIAMGGSTNTV
                     LHLLAVAHEAEVDFTMKDIDMLSRKTPVICKVAPSCSYHVEDVNRAGGIIGIMNELVKA
                     GLVDGSVKRADGLTLNEAIDQYCITSVNVTEEAINIYKSAPAHRFNLVLGSQESYYKEL
                     DTDRATGCIRDVEHAYVKDGGLAVLYGNIAQDGCVVKTAGVDESIFRFAGPAKVFDSQD
                     AACEGILKDQVVSGDVVVITYEGPKGGPGMQEMLYPTSYIKSKHLGKECALITDGRFSG
                     GTSGLSIGHISPEAAAGGAIGLVKDGDIIEINIPERTIHVKVTDEELAKRREAEEARGT
                     KAFTPPFRQRTVSKALKAYAKMVASADKGGVRIVED"
     CDS             1443..3143
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg45_3"
                     /sec_met_domain="TPP_enzyme_C (E-value: 5.1e-51, bitscore:
                     162.5, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKQKITGSEALLKALIAEGVDTIFGYPGGQAIPIYDSLYDYRDQ
                     LKHILVRHEQGATHAAQGYARVSGKVGVTVVTSGPGATNTITGIADALMDSTPMVVIAG
                     QVPSPLLGTDAFQEVDVIGITQPITKWAYQIRRPEEIAWAVSRAFYIASTGRPGPVVLD
                     LAKDAQVGLVDYEYQKVDYVRSYQPEPDIREERIEAAASLINNAKKPFCLVGQGVILGG
                     AEEELKEFLLKNDIPAGSTVLGLSALPSDFPLNKGMLGMHGNVGPNRKTNECDVLIAIG
                     MRFDDRVTGDLKTYAKQAKIIHLDIDNSEIGKNVPVDVKVLGNAKHTIPMITALLEERK
                     RPEWNAEFEPDEKEEYNKVIEKELYPTEGQLKMGEVVRKVSEATDNDAILVTDVGQNQM
                     MGVRYFKYKQTRSVVTSGGLGTMGFGLPAAIGAKLGAPDRTVCFFTGDGGIQMTIQELG
                     TIMQENLNVKIIVLNNNFLGMVRQWQELFFNERYSNTIMKNPDFVAIAKAFGIASRAVD
                     KREDLDEAIAEMLNHDGAYMLVANVETCGMVYPMVPAGGSVTNMILGDK"
     CDS             3156..3710
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg45_4"
                     /sec_met_domain="ALS_ss_C (E-value: 1.7e-18, bitscore:
                     56.7, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNTKQLYTVIIFSENTVGLLNQITVIFTRRQLNIETLSVSPSAIK
                     GIHKFTITTFADEDTIDKVVKQIDKRVDILKAYYNTDEDLVYQEIALYKLSTELFIKMG
                     TVEDLIRKYNARILEMNEDCVVLEKSGHYDETQALFKELSETIGVLQFIRSGRVAITKS
                     KVERLSDMLSAMEKKLQEKHV"
     CDS             3747..4478
                     /locus_tag="ctg45_5"
                     /transl_table=11
                     /translation="MEKNKVGEFHFVTESYLMDFRGRITIPMIGTYLLHAASCHAADRG
                     FGYNDMTERHTAWVLSRLAIEMTSYPAMSESVTLYTWVDEVGKLFTSRCFELVNGEGKT
                     FGFARSIWAAIDMETRRPTLLDVEGLSAYITDRPCPIEKPGKIAPVENNTSGEPYRVKY
                     SDLDVNGHLNSIKYMEHLLDLFDISLFREKEISRFEIAYQSEGKYGMELTLHNQEVSPG
                     KYNMAICNDGKAISRAAVTWI"
     CDS             4520..5566
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: IlvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg45_6"
                     /sec_met_domain="IlvN (E-value: 1.8e-48, bitscore: 154.2,
                     seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="IlvC (E-value: 4.2e-44, bitscore: 140.3,
                     seeds: 295, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAVMNFGGVDENVVTREEFPLEKAREVLKDETIAVIGYGVQGPGQ
                     SLNLRDNGFNVIVGQRKGGKTWEKAVADGWVPGETLFDIEEACEKATIIQYLLSDAAQI
                     EVWPRIKKYLTPGKALYFSHGFGITYKERTNIIPPADVDVILVAPKGSGTSLRRMFLQG
                     RGLNSSYAIFQDATGKAWDRVIALGIGVGSGYLFETTFKKEVYSDLTGERGTLMGAIQG
                     LLLAQYETLRENGHEPSEAFNETVEELTQSLMPLFAENGMDWMYANCSTTAQRGALDWM
                     GPFHDATKPVFQKLYSEVACGNEAQRSIDTNSKPDYREGLEKELAALRESEMWRAGAVV
                     RKLRPENN"
     CDS             6068..9346
                     /locus_tag="ctg45_7"
                     /transl_table=11
                     /translation="MISVLLGAAGAIAANPTGPETMVVQQGNKVTGLVEDQMGPVAGAS
                     VVVKGTTIGTITDIDGKFTLDNVRRGAVIVISFVGLATQEITWNGQSILNVKLSDATQD
                     LDEVVVVAYGTAKKSTFTGSASVVKAEKLEKIMGSGFAEALQGMSAGVNVVNVQGNPGA
                     DARVEIRGIASMSGKADPLYIVDGMPYDGKLNQINPTDIESMTVLKDAAATSLYGSRAA
                     NGVVMITTKRGKSEKPRINFRGGWGTSDNAVKNPKKADPYQQLENTWYALYYDALLYDG
                     MNMQQAGDYASSQALTKQVKATKDSNGNLIYVTPFRHINENYVLHDGNGNPYMNPNLEY
                     VWDEDDWDVYKAIFSRKLRQDYSVDISGQANGGKTAYFFSGGYLDDQGYGNRQYYKRYS
                     FRTNLSTELFDWWKVAGSLSYSRHRQNLSGGASRAANFTTTLSSPWLRNEDNTGWVVSE
                     KTGERMYSYGKYTNNFFGAHILNNSGDYWDNPNDDSFDNNMGHILSAQVNTEFTLPFNL
                     KFRSALNIDDYWYRTMQYTSAVHGSGQTAPYGISILADGGYASRYNFNKRSTTWNNVLS
                     GEWMIGDHTISGLVGHEWYTWDSHYEQGWGEGIMELGKYELSNTTKNFGVSGGRDKYSL
                     LSFFGKVDYNFLNKYYLSASLREDGSSRFSSDHRWGTFWSTGGSWRISKEGFMEDLKWI
                     DNLSLRGSYGTTGNDKLIVRESNGKAGDEVLYGYQGTYESDDLYLKSGLKPSTYPTPDL
                     KWESNQQWNIGLDFSVFNRLSGTVEYYSRTSHDLLYYKELPLSAQVGSASGYNMNIGDL
                     RNSGIEITLNANILTTKDFRWDIDANMSTLKNEVTYLPTGPYTYSGTACTYKMEEGKSL
                     YEFIAPQYDGVNPETGVPGWLIRDGNGGWKRTEKQEEVTTDDFVYCGSAIPKVFGAITN
                     NFQFKGIDLSFMFYYSYGSKISDYTYKERIMNRPGVGVIQELVEDRWRQPGDADVLIPR
                     WSYNQYGATVKYADNFVFDNHYWRLRNLTLGYTLPKSLTRKALVENLRVYVTGNNLLTF
                     GPAKKRYTDPETGIMGNSYNGNAETDNGIQGSRRLYMVGIQITL"
     CDS             9365..10954
                     /locus_tag="ctg45_8"
                     /transl_table=11
                     /translation="MKRFINISFLSLVFAGMALTGCNDDLTTSSYVKVNDEDVLGNVSQ
                     LEKVLTSAYKQLYFNTDKGDRVYAGLPGFQMYVDASGADVISHTNMGGDQVTAYQYSNS
                     KTQADGNASKIWSMCYNVINRANIILTNVDAAAGDETQKKHIKGQALAMRGIQYFHLIQ
                     NYQQTYVIAKSKRGVILRTSSDDESHKGFSTVEEVYTQIVSDLTTAKTLLADYNPDDMW
                     LINSKICSGILARVYLVMQNWDGAYNEAKIVYDQHGQLMTREQYRSGFDDMISGNYAEV
                     VWAMKYTADNNLGGSTQFNFWYNQDASYGEGYADGPIYSFLDYFVDEQFVKLFEEKEDR
                     YQFWKRTNNANTEINTKWAFDKYKHYGEDGGSVIQSATRPEVCLMRGAEMLLIMAEAAA
                     QKGNSGEALNLLNRLQVARNATPTTNAGGEALLEDIYVERRKELICEGQAGFYDLVRLQ
                     KRLVRIGESTTNPAGHYVWGMQYLNGYNALDPQPIGTLESNDYRFFCQIPQMEILNNDA
                     ISESDQNPWSGQ"
     CDS             11473..11604
                     /locus_tag="ctg45_9"
                     /transl_table=11
                     /translation="MSLRKIVSLSTDNSEHDISETVDANQSRMETSLPVTKQTEKSK"
     CDS             11623..11727
                     /locus_tag="ctg45_10"
                     /transl_table=11
                     /translation="MNIMSVNGLWRKQTYFLFVHSRKGKHTFINITDI"
     CDS             12589..13752
                     /locus_tag="ctg45_11"
                     /transl_table=11
                     /translation="MNKISLLFILSVLITFSAYAQDDIKITHAPYLQNLGENEVTVVWT
                     ANKPSIGWVELAPDDGTHYYQTERPKFFNAKNGIKLTSTVHSVHLTGLKPGTRYRYRVY
                     SQEVLSHVGWRVIYGNVAATSVYGKQPLTFLTSDHGRQSVNFAMVNDIHGKSDVLEKLV
                     SHCDLKKTDMFLFNGDMVSIFNNEKEIFEGFMDKATELFASEIPMYYTRGNHETRGSFA
                     TAFQDYFSPKQEHIYYMFRQGPVCFVILDSGEDKPDSDLEYAGITVYDQYRTEQAEWLK
                     KVLESKEYKEAPFKVVVCHMPPFGGWHGEQEVAEKFIPLLNNAGVDLMLCGHLHRYMRN
                     EPKDGVRFPVIVNSNNTVLKAEAGVKELNIRILDMEGKEVDKLTITK"
ORIGIN
        1 ccgacaatct ttgtatccgg cggtccgatg gaagccggta atctggacgg acgtgcactc
       61 gatttgatcg acgccatgat tgaagcggct gacgattcta tcagcgatga acaagtagaa
      121 aaggtggaac gttccgcttg cccgacctgc ggttgctgtt ctggtatgtt cacggctaac
      181 tctatgaact gtctgaacga agcgattgga ttggctcttc ccggcaacgg aacagttgtt
      241 gcaacacatg ccaaccgtac ccgcctgttc taaaaagccg cgaagatgat tgttgataat
      301 gcctttaaat attatcgtga cggcgatgat tccgtattgc ctcgcagtat tgccacccgt
      361 caggccttcc tgaatgctat gtcgctggat attgccatgg ggggatcgac gaatacagtc
      421 cttcacctgt tggccgtggc tcatgaagcg gaagtcgatt ttacaatgaa agacatcgat
      481 atgctttcac gcaaaacacc ggttatctgt aaagtggctc cgagttgttc ttatcatgtg
      541 gaagatgtga accgtgccgg aggtatcatc ggtattatga atgagctggt aaaagccggt
      601 ctggtggacg gttccgtgaa acgtgcggat ggtctgactt tgaatgaggc tatcgaccaa
      661 tactgcatta cctctgtaaa tgtaacggaa gaagcaatca atatttataa aagtgctccg
      721 gcccaccgtt tcaacctggt gctcggatcg caggaaagtt attataaaga actggatacc
      781 gaccgtgcaa ccggatgtat ccgcgatgtg gaacatgctt atgtgaaaga cggcggtctg
      841 gctgttctgt atggaaatat tgcacaggac ggttgtgtgg ttaaaacagc cggggtagat
      901 gaaagtatct tccgttttgc cggtcctgcc aaagtattcg attcgcagga tgccgcttgt
      961 gaaggtatcc tgaaagatca agtcgtctcc ggcgatgtcg tcgttatcac ctatgaaggt
     1021 cctaagggtg gtccgggtat gcaggaaatg ttgtatccta cctcttatat aaagagtaaa
     1081 cacctgggta aagaatgtgc gctaatcaca gacggacgct tcagcggtgg aacatcaggt
     1141 ttgtcaatcg gacatatttc tcccgaagcg gctgcaggcg gagcgattgg cttagtgaaa
     1201 gacggcgata ttatcgaaat taatattccc gaaagaacca tacatgtaaa ggtgacagac
     1261 gaagaactgg ccaaacgccg tgaagcggaa gaggcccgcg gaacaaaagc ctttacacct
     1321 cctttccgtc aacgtacggt atcgaaagca ctgaaagcat atgcaaagat ggttgcttcg
     1381 gccgataagg gcggtgtacg aatagtagaa gattaataaa caccaaatac tatattttag
     1441 agatggacaa acaaaagata accggttcgg aagctttgct gaaagcgctg atcgctgaag
     1501 gagtagatac tatcttcggt tatccgggtg ggcaggcgat accaatttac gatagtttat
     1561 acgattacag agatcagtta aaacatattc tggtgcgcca cgaacaaggt gcaacacatg
     1621 ctgcacaggg atatgcccgt gtttccggaa aagtgggagt aacggtggtt acttcgggtc
     1681 ccggggcaac caataccatc actggtattg ccgatgcgct gatggacagt acaccgatgg
     1741 tggtgattgc cggccaggtt ccgtctccgc tgcttggaac agatgctttc caggaagttg
     1801 atgtaattgg tatcacacaa ccgattacca aatgggctta ccagatacgc cgcccggaag
     1861 aaattgcttg ggccgtttcc cgtgctttct atatcgcatc gaccggtcgc ccgggacctg
     1921 tggtattgga tttggcgaaa gatgcacagg tgggtttggt agattatgag tatcagaaag
     1981 tggattatgt tcgtagttac cagcctgaac cggatatcag ggaggaacgt atcgaggcgg
     2041 ctgcttcatt gataaataat gccaaaaagc cattctgtct ggtagggcag ggggttatcc
     2101 tgggaggagc cgaagaagaa ctgaaagaat tcttgttgaa aaacgatata ccagccggtt
     2161 ctaccgtatt gggcttgtct gcattacctt cggacttccc attaaataaa ggtatgttgg
     2221 ggatgcatgg aaatgtcgga ccgaaccgca agacaaacga atgtgacgtg ctgattgcta
     2281 tcggtatgcg tttcgatgac cgtgtaaccg gcgacctgaa gacttatgcc aagcaggcaa
     2341 agattatcca cctggatatc gacaattcgg agatcggaaa gaatgtgccg gtcgacgtga
     2401 aagtgctggg aaatgccaag catacgattc cgatgattac ggctttactg gaagaacgga
     2461 agcgtccgga atggaatgct gaattcgaac cggatgaaaa agaggaatat aataaggtaa
     2521 tagaaaaaga actctatcct accgaaggcc aactaaaaat gggcgaagta gtccgtaagg
     2581 tttccgaagc aaccgataat gatgcgattc tggttacgga tgtaggtcag aaccagatga
     2641 tgggtgttcg ctatttcaaa tataaacaaa cacgcagcgt agttacttca ggaggtttgg
     2701 gaacgatggg ctttggcctt cccgccgcca ttggagcgaa gctgggagcg cctgaccgta
     2761 cggtctgttt ctttaccggc gacggtggta tccagatgac tatccaggag ttgggaacta
     2821 tcatgcagga aaatctgaat gtaaagatca tcgttcttaa caacaatttc ctgggaatgg
     2881 tacgccagtg gcaggagctg ttcttcaacg aacggtattc gaataccatc atgaagaatc
     2941 cggattttgt agcgatagcc aaggcttttg gtattgcttc ccgtgcggta gataaacggg
     3001 aagacttgga tgaggcgatt gctgaaatgt tgaatcacga tggtgcctat atgttggttg
     3061 ccaatgtgga aacttgtggt atggtatatc cgatggttcc ggccggagga agcgtgacaa
     3121 acatgatttt gggtgataag taaggaggag aaactatgaa tacaaaacaa ttatataccg
     3181 ttattatctt ttcggaaaac actgttggtc ttctgaatca gataactgtt atctttacgc
     3241 gccggcaact gaacattgag acgctttctg tttctccctc tgctataaag ggaatacata
     3301 agtttacaat tactaccttt gccgacgagg atacgatcga caaggtcgta aaacagatcg
     3361 acaagcgtgt ggatatcctg aaagcctatt ataatacgga tgaagacctg gtttaccagg
     3421 aaattgctct ttataaactg agtaccgaac tctttatcaa gatggggacg gttgaggatc
     3481 tgatccgtaa gtacaatgcc cgtatccttg aaatgaatga ggattgtgtg gtgttggaaa
     3541 agagtggtca ttatgatgag acacaggctt tgtttaaaga attgagtgag acgatcggtg
     3601 tcctgcaatt tatccgttcc ggacgcgttg ctataacgaa gagtaaggta gaacgtctga
     3661 gcgacatgtt atctgcaatg gaaaagaagt tgcaggaaaa acatgtctga gaataataag
     3721 gaaacatttt gtaaataaag taaattatgg agaagaacaa agtaggagaa tttcatttcg
     3781 taacagagtc ttatctgatg gacttccggg gacgtattac aatccctatg atcggaactt
     3841 atttgttgca tgctgcttct tgccatgccg ccgaccgtgg attcggatat aacgatatga
     3901 ccgaaaggca taccgcctgg gttctttccc gtctggctat cgagatgact tcttatcctg
     3961 ctatgtctga atctgtaact ttatatacct gggtggatga ggtcggtaag ttgtttacca
     4021 gccgttgctt tgaactggtg aacggcgaag gcaagacctt tggctttgcc cgctctatct
     4081 gggcggctat cgatatggaa acccgccgcc cgaccttgct cgatgtggag ggcctgagtg
     4141 cttatatcac cgaccgtccc tgtccgattg aaaaaccggg taaaattgct ccggtggaaa
     4201 acaacacttc cggcgaacct taccgtgtga agtacagtga cctggacgta aacggccacc
     4261 tgaacagtat caaatacatg gaacacctgc tcgacttgtt cgatatcagc ctgttccgag
     4321 aaaaagagat aagccgtttc gaaatagctt atcagtccga aggaaagtat gggatggagc
     4381 tgactctcca taaccaggaa gtatcccccg gtaaatataa tatggcaatc tgtaacgacg
     4441 gcaaagccat cagccgcgct gccgttacct ggatctgaaa aacaaattat tttatataca
     4501 ttttaatagt aaaaagaaaa tggcagtaat gaattttggc ggcgttgacg aaaacgtagt
     4561 aacccgcgaa gaatttccgt tggaaaaggc aagagaagta ttgaaagacg aaacaatcgc
     4621 tgtaataggt tacggcgtac aaggtcctgg ccagagcctg aacctgcgcg acaacggttt
     4681 taacgtaatt gtaggacaac gtaaaggtgg taagacctgg gaaaaggccg ttgctgacgg
     4741 ttgggtaccg ggcgaaacac tgttcgatat cgaagaagca tgcgaaaaag caactatcat
     4801 ccagtatctg ctttcagatg ctgctcagat tgaagtttgg ccgcgcatca aaaaatacct
     4861 gactccgggt aaggctttgt atttctctca cggattcggt atcacttaca aagaacgtac
     4921 aaacatcatc cctcctgctg atgtagacgt aatcctggtt gctccgaaag gttcaggtac
     4981 ttcactgcgc cgtatgttct tgcagggtcg tggtctgaac tcaagctacg caatcttcca
     5041 ggatgcaaca ggcaaagcat gggatcgcgt gattgcactg ggtatcggtg ttggttctgg
     5101 ttacttgttt gaaacaacat tcaagaaaga agtttattct gacctgaccg gcgaacgtgg
     5161 tactttgatg ggagctatcc agggattact gttggctcag tacgaaactt tgcgtgaaaa
     5221 cggtcacgaa ccttctgaag cattcaatga aacagtagaa gaactgactc agtcattgat
     5281 gccgttgttc gcagaaaacg gtatggactg gatgtatgca aactgttcaa caactgcaca
     5341 gcgtggtgct ttggactgga tgggcccgtt ccacgatgct acaaaaccgg tgttccagaa
     5401 gttgtatagc gaagttgcct gcggtaacga agcacagcgt tctatcgaca caaacagcaa
     5461 gcctgactat cgtgaaggtc tggaaaaaga actggctgct cttcgcgaaa gtgaaatgtg
     5521 gcgtgcaggt gctgttgttc gtaaacttcg tcctgaaaac aactaataaa tggtgataca
     5581 ttaatagtta aacattttgt gatataaaaa cggcaatccg gcttttcggg ttgccgtttt
     5641 tttatggttt atgtaatgcg ttaatggtta aaaaatgttt ttgattgcaa ctgttattga
     5701 tttttcatcc caatatgtat gtcattgttt gaatgtggat tttagataaa aaaatcaatt
     5761 aaatggtggt taaaatatat ttattagagc aataaatata cataattatg cttgtattaa
     5821 ataatgataa gttatatttg ctgatggaga tactgtagtt tgtagagtgg aaatatagaa
     5881 ggatgttgtg tgtaatgatc agtatatctt tgttttagtt aactttattt tattgaaatg
     5941 tatgccagtc acttttatct tagaaaagtg taacctctaa tgaaatgaac gctattgtga
     6001 ttaattttat ttaattaaag acttgaattt agctatgtgg accaactcaa aactaattag
     6061 atcactaatg atttctgtat tattaggtgc ggcaggtgcg attgctgcca atcctacagg
     6121 tccggaaacg atggtagtac aacagggtaa taaggtaacc ggcctggtag aggaccagat
     6181 gggacctgtc gccggagctt ctgttgtagt gaaaggaacc actatcggta cgataaccga
     6241 tatcgatgga aagtttacgc tggataatgt tcggcgggga gcggttattg ttatttcctt
     6301 tgtcggcctg gccactcagg agatcacttg gaacggacaa tctattttaa atgtaaaatt
     6361 aagtgatgcg acacaggacc tggatgaagt cgttgttgta gcctatggaa cggctaagaa
     6421 atcaaccttc accggatcgg cctccgttgt aaaagctgaa aaactcgaaa agatcatggg
     6481 ctccggcttt gcggaagcat tgcaggggat gagtgccggt gtgaatgttg tgaatgtaca
     6541 gggtaacccc ggagctgatg cccgtgtgga gatccgtggt attgcttcca tgtccggaaa
     6601 ggccgatccg ttatatattg tggacgggat gccttacgat ggaaaactga atcagatcaa
     6661 tcctacggac atagaatcga tgacggtgct gaaggatgcg gcggccactt cgctttacgg
     6721 ttcgcgtgca gcaaacggcg tcgtaatgat tacaaccaag cggggtaaat cagaaaaacc
     6781 gcgtattaac ttccgcggag gttggggtac ttcggataat gctgtcaaga atccgaaaaa
     6841 agccgatccg taccagcagc tggaaaatac ctggtatgcc ttgtattatg atgcccttct
     6901 ttatgacggc atgaatatgc aacaggcggg cgattatgct tcgtcacagg cattgaccaa
     6961 acaggtaaag gctacaaaag attcgaatgg taatctgatt tatgtcactc cgttcagaca
     7021 tatcaatgaa aattacgtat tgcatgacgg caatgggaat ccttacatga atcctaatct
     7081 ggaatatgtc tgggatgaag atgattggga tgtctacaaa gctatcttct cccgtaaact
     7141 gcgccaggat tatagtgtgg atataagtgg tcaggccaat ggtggaaaaa cagcctattt
     7201 cttctccggc ggttatctgg acgaccaggg atatggtaac cggcagtatt ataaacgtta
     7261 ttctttccgt accaacctga gtacagagtt gttcgattgg tggaaagtgg ccggtagcct
     7321 ttcttattcg cgtcatcgcc agaacctttc cggtggtgcc agccgtgcgg ctaactttac
     7381 gacgactttg tcttcaccct ggttacgtaa tgaagataat accggttggg tcgtttctga
     7441 aaaaacaggg gaacggatgt acagttacgg taaatatacc aataacttct ttggtgccca
     7501 tatcctgaat aactcgggtg attattggga taatccgaac gatgacagtt tcgataacaa
     7561 tatggggcat atcctgtctg cccaggtaaa tacagagttt actcttcctt tcaacctgaa
     7621 attccgttcg gctttgaata ttgacgatta ctggtatcgt accatgcaat atacttccgc
     7681 cgtacatggc agcggacaga ctgcacctta tggtatttct atactggcag acggtggtta
     7741 tgccagccgt tataatttca ataaacgttc caccacctgg aataatgtat tgtctggtga
     7801 atggatgatt ggtgaccata cgatttcagg tctggtcgga catgagtggt atacctggga
     7861 ctcccactac gaacaaggtt ggggtgaagg tatcatggaa ctgggtaaat atgaattatc
     7921 gaataccacc aagaacttcg gtgtttccgg cggacgtgat aaatactctc tgctttcgtt
     7981 cttcggtaaa gtcgattata acttcttgaa taagtattac ttgtccgctt cgcttcgtga
     8041 ggatggttct tcccgtttca gctccgatca tcgctggggt acattctggt cgacaggcgg
     8101 ttcatggcga atatcgaaag aaggttttat ggaagacctg aaatggattg ataacctttc
     8161 gttgcgtggt agttacggta cgaccggtaa tgataagctg atcgtgcgtg aatcgaatgg
     8221 taaggcaggg gatgaagtcc tttacggata ccagggtact tatgaaagtg atgacctgta
     8281 tctgaaatcc ggtttaaaac catctaccta tccgacaccg gacttgaagt gggaaagtaa
     8341 tcagcaatgg aatatcggtt tagatttttc cgtattcaac cgacttagcg gtacagtgga
     8401 atattattcc cgtacttccc atgacttgtt gtattataag gaactgcctc tctctgccca
     8461 ggttggtagt gcatccgggt ataatatgaa tatcggtgac ctgcgtaata gcgggattga
     8521 aatcacattg aatgcgaata tccttacaac gaaagatttc agatgggata tcgatgccaa
     8581 catgagtacg ctgaaaaatg aggtgactta tttgcctaca ggtccttaca cttattctgg
     8641 taccgcctgt acctacaaga tggaggaagg caagtctctg tatgaattta tcgctcccca
     8701 gtacgacggt gttaatccgg aaaccggagt acccggctgg ttgatccgcg atggtaacgg
     8761 cggttggaaa cgtacggaaa agcaggaaga agtaacgaca gacgattttg tgtactgtgg
     8821 ctccgcgatt cccaaagtgt tcggtgctat caccaataac ttccagttca aagggatcga
     8881 cctgtcgttc atgttctatt attcttatgg ttccaaaata tcggactata catataaaga
     8941 acgtatcatg aaccgtccgg gtgtcggtgt gatacaggag ttggttgagg acagatggcg
     9001 tcagccgggc gatgcggatg tgcttatccc acgttggtcg tacaaccagt atggcgcgac
     9061 ggtaaaatat gcagataact tcgtattcga caaccactac tggcgtctga gaaacctgac
     9121 attaggctat acgctgccta agagccttac ccgcaaggcc ctggtagaaa acctgcgtgt
     9181 ttatgtaacc ggtaataacc tgttgacttt cggtcctgcc aaaaaacgct acacagaccc
     9241 cgaaacaggt ataatgggta acagttataa cggtaatgct gaaaccgata acggtattca
     9301 gggttcgaga agactgtata tggtcggtat tcaaatcaca ttgtaaacgt aaaaaatgat
     9361 atttatgaaa cgatttataa atatatcctt cctgtccctg gtttttgctg gtatggccct
     9421 gaccggatgt aacgacgacc tgacaaccag ctcctacgtg aaagtaaacg atgaagatgt
     9481 actggggaat gtctcccagt tggaaaaagt attgacttca gcctataagc agctgtattt
     9541 taataccgat aaaggcgacc gtgtgtatgc cggtcttccc ggattccaga tgtatgtcga
     9601 tgcgagtggt gccgacgtga tcagccatac caatatggga ggcgatcagg taacagcata
     9661 ccagtattcc aactctaaaa cacaggctga cggaaatgcc tcaaaaatct ggtcgatgtg
     9721 ctataatgtg atcaaccgtg ccaatatcat cctgaccaat gtggatgccg ccgccggtga
     9781 tgaaacacag aaaaaacata tcaaaggcca ggcgttggcg atgcgtggaa tccagtattt
     9841 ccatctgatc cagaattacc aacagaccta tgtgatagcc aaaagcaagc gtggggtgat
     9901 tctgcgtacc tcttccgatg acgaatccca taaaggtttt tctaccgtag aggaagtcta
     9961 tacccagatt gtgtccgacc tgacgacggc taaaacattg cttgccgatt ataatccgga
    10021 cgatatgtgg ctgattaact ccaaaatatg ttcaggaatc ctggcccgtg tttacctggt
    10081 gatgcagaac tgggacggcg cttacaacga agccaagatc gtctacgacc agcacggcca
    10141 gttgatgacc cgcgaacaat accgttccgg tttcgacgat atgatctccg gcaattatgc
    10201 ggaagtggta tgggccatga aatataccgc cgataataac ctgggcggta gtacgcagtt
    10261 caatttctgg tataaccagg atgccagcta cggcgagggt tatgccgatg gtcctatcta
    10321 ctcgttcctt gactacttcg tggatgagca gtttgtgaaa ctatttgaag aaaaagaaga
    10381 ccgttaccag ttctggaaac gtacgaacaa tgcgaatacg gaaatcaata caaaatgggc
    10441 tttcgacaaa tacaagcatt atggtgaaga cggcggaagc gttattcaaa gcgccacccg
    10501 tccggaagtc tgcctgatgc gcggagccga aatgctgctg attatggcgg aggctgctgc
    10561 ccaaaagggt aactccggcg aggctctgaa tctgctgaac cgtttgcagg tggcgcgtaa
    10621 tgctaccccg acaaccaatg ccggaggcga agctttgctg gaagacatct atgtggaacg
    10681 ccgtaaagag ttgatctgtg aaggacaagc cggtttttat gacctggtgc gcctgcaaaa
    10741 gagattggtt cgtatcggtg aatcaactac caatcctgcc ggacattacg tatggggcat
    10801 gcagtatctg aacggatata atgcgctcga tccgcaaccg atagggacgc tggagtcgaa
    10861 cgattaccgt ttcttctgcc aaatcccgca aatggaaatc ctgaataatg atgcgatctc
    10921 cgaatcagat cagaatccgt ggagcgggca gtaagtttca tctgttgtaa ataaataaaa
    10981 gagagggagg tgtttattac atgcctccct ctcttttatt tgtaacattt gatgttcact
    11041 gttttacttt ttgtccttta gcacttcctg taacatggcc accttctcct gctccgcttt
    11101 caataaacgt tcgtataatt caacgacttt ttctaagggg ttaaatgtag gattataatt
    11161 ctggcaatta gcattatctt gccaggtgcc ggaaaagata ttaatggaag tggcttcgcc
    11221 tagttccgta attgcttctt cgggtatatc taatgctttg gcaatctttt cgattacttc
    11281 cggctccaga ttacttcttt tttcgtatgt cgaaagggtt ggtagaaaat aaatccggtt
    11341 tatctctcat aataaatatc ggaaagagtt gcctgataat atttgtacca cagaaaaaac
    11401 acatcaaagg tcaggcgctg gcgatgcgtg gaatccagta ttttcacctg atccagaatt
    11461 accagtaaac gtatgtcatt gcgaaaaata gtttctcttt caaccgataa tagtgaacat
    11521 gatatcagtg aaacggtcga tgcaaatcag agtcgtatgg aaacttcact tcctgtaacc
    11581 aaacagacgg aaaaatcaaa atgatataaa aatgaatgat atatgaatat tatgagtgta
    11641 aatggccttt ggaggaaaca gacttatttt ttatttgttc attctagaaa agggaagcat
    11701 acatttatta acataacaga tatctgatat cgacttttta tctcgtttaa accgaagaaa
    11761 attttagttt aaacagattt caatttcgtt taaactgaga taaatttcta ttgtagtgga
    11821 gtttttattc gtttagagaa ggaaaacacc tcaattagtg cttttaaaag agaaaatcat
    11881 atgtttttag acagttttta tttccagagc aaccgttttt tgatgtgtgt gtaaaatagc
    11941 aatatgttaa taaattatga atagatgtgg tatatgggta acaatcatag ataatataca
    12001 ttttttgtga tatgaatatt gcaacaatca ggtcaaagcg aataaaggta agtcggcgag
    12061 atttctataa aaacagatcg acatttccct ttgtccgtac aattccttca gcacatacat
    12121 aaaatatcat tttgacaatc ctttaacttc caggaactct cctgacgctt tgtatccaat
    12181 agtatgttct ccggatagga cttggctttt atatcccaaa aagtaaatca tcaatagtaa
    12241 acaaggcaac cgcagcaaaa ggatgtttca atatagaaat atttgaacta tcccgttccc
    12301 gtgctcgaca cgggatcgca aaagcacaaa ccgtatccta tatgtatctt ttgatactgc
    12361 ctgttcttct gcggccccgt gtcaagcacg gggacaggat agttcatatc tgataagaaa
    12421 tgaaccaaat tcttttggta tagtttaatc agtcataaaa ggagaggcgt gtctgtgaag
    12481 gtgtgcttct ttcctgtaga taacgggatt taatcccggt agggtttgcc ggaataaatg
    12541 aagaatgtat ctttgtagga gatcgttaac aacttaaaaa gatataccat gaataaaatc
    12601 agtttgctgt ttattttgtc tgtattaatc actttttctg cttatgccca ggatgatata
    12661 aagataacgc atgcccctta tctgcaaaat ctgggagaaa atgaagtcac tgttgtatgg
    12721 actgcaaaca agccttcgat cggttgggtg gaactggctc ccgatgacgg aactcattat
    12781 tatcagacgg aacgtccgaa gttctttaat gcgaagaatg gcatcaagct gacctctacc
    12841 gtccattctg tgcatctgac agggttaaag cccggcacac gttatcgcta ccgggtgtat
    12901 tcgcaggaag tgttaagcca tgtcggctgg cgggtgattt acgggaatgt ggcggcaacg
    12961 tctgtttacg gcaagcaacc gctgacgttc ctgaccagcg atcatggcag gcaatccgtg
    13021 aactttgcca tggtcaacga tatccacgga aaaagtgatg tgctggaaaa actggtttcc
    13081 cattgcgatc tgaaaaagac cgatatgttt ctgttcaatg gcgatatggt ctctattttc
    13141 aacaatgaaa aggaaatatt cgaaggcttt atggataagg caaccgagct tttcgcctcc
    13201 gagataccga tgtactatac ccgtggaaac catgaaaccc gcggttcctt tgctaccgca
    13261 ttccaggact atttctctcc gaaacaggag cacatctatt atatgttccg ccagggacct
    13321 gtctgctttg ttatcctgga cagtggcgaa gataaaccgg attcggatct tgaatatgcc
    13381 ggcataacag tctatgacca gtatcgtacg gaacaggcgg aatggttgaa gaaggtactt
    13441 gaaagcaagg agtataaaga agcaccgttt aaagtcgtag tttgccatat gcctccgttc
    13501 ggtggttggc atggtgagca ggaagttgcc gaaaagttta tccccttact caataatgcc
    13561 ggtgtcgatc tcatgctttg cggccacctt caccggtata tgcggaatga accgaaagac
    13621 ggtgttcgtt ttccggttat tgtaaactcc aataatacgg tgctgaaagc ggaagcaggc
    13681 gtaaaagaat taaacatcag gatactggac atggagggga aagaggtgga taagctgaca
    13741 ataaccaaat aagacatata gatgggagaa acatcctccg gctgaactat caaaaatagg
    13801 aagaatagaa tcagttttga aaataacctg ttgaagcaga ggttctatat ttgtacaatc
    13861 ataaaaacgg taatcattgg tataacctaa atagaatctt taatgaaagg tattttcttt
    13921 gtcatatgta tgtgttttgt ctcgtttgga gtatctgccc aggtcagtga gtcagctttt
    13981 gtaaatccgg agaataaata taagcctgtt cctttgtggt tttggaataa tgcgacggtc
    14041 aatgaaaacg aattgctgga ccaattccgt cagatgatcc gaaaagacgg gtatggcggt
    14101 tgtgcaatcc ttcctttcgg gcaagacttc aagccggaat atctgtcaga cgattatttc
    14161 aatctttata gcaagattat agaggaagcc aagaaactgg atgtgcatat gtccctgtat
    14221 gatgagtatg gttttccgag tggaagtatg ggagccatca acgcggatgg ggtacctcgc
    14281 ttcatgaaca aatatccgga tgccacgatc aagcggctgg acaaaatgga gtataaagta
    14341 gctgtcggcg aatcattcga acaggtcgtt cctgccggaa aactgatgtc ggtcgttgca
    14401 atggacacgc tgacgaagca tcggatttcg ctggaacaat atattcgttc cggtaaactc
    14461 aaatggaaag ttccggaagg agcctggaag atcatgtttt tcgtctgtgt gaaagatggc
    14521 gacccgaatg tggattatct ggaccctgaa gccgtcaggc tgtttgtaaa agaaactcat
    14581 caggcatatt atgaccgttt ctctccctat ttcgggaata cgatcataga aacttttttt
    14641 gatgaaccga ccctgtaccg ggctaaggga cgtatctgga cagacgcgtt taacgagaaa
    14701 tttatctccc gttacgggga atctcccgaa ttactgtatc cggcattatg gtatgacatc
    14761 ggggaggaaa cgcaatctgc gcggaaccgt ctgtttggct tgcgtgccca tttgtattcc
    14821 gaaggtttta tgaaaataat cggtgaatgg gcttctgccc atggcattta ctctaccggt
    14881 catcaggatc aggaagagat tgcaaatccg gtgggtactt ctggtgactt gatgttatgc
    14941 gggaaatata tggggattcc cggtattgac aaaattggcg gaggccgtcc gaccgaattg
    15001 ttttataaag tggtttcttc ttctgcctat aactgggaca aacgccaggt aatgtccgaa
    15061 acatacggcg ctatggggaa tatcagtgta aaagagcttt accacatagc catggaacaa
    15121 tatacgaaag gggtcaatac gcttatccca catgctgtct ggtataatga tcggaatgtt
    15181 actttcctgc ctgagttatc ctggcggaac gaactgtacc gcgattcact tccggcattt
    15241 aataagttcc tgtcccgtct caactatatt ttgcggcagg aaggaagaca tgtcgccgat
    15301 atagcagtcc tttatccgat cgaatctctt cagggagaac atgtgatgga tggggaactg
    15361 ggattttatg aaggcggggt aatgatcccg aatacggatt atacacatgt ctcggcttta
    15421 ttgactgata ccctcgggcg tgatttcact tatctgcatc cggaggtctt atctacaaaa
    15481 tgccgtgtga aaaaaggatt gttgcacctc gacaatcagg tgaacaaaga aactttccgg
    15541 ttgattatta ttcccggagt aaaaac
//
