LOCUS       c00017_gnlPro..        16607 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|LNBCGMOJ_17.
ACCESSION   c00017_gnlPro..
VERSION     c00017_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-05 01:25:34
            Original ID  :: gnl|Prokka|LNBCGMOJ_17
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16607
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16607
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[1494:6607]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      1495..6607
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..16607
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..16607
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             485..874
                     /locus_tag="ctg17_1"
                     /transl_table=11
                     /translation="MPSRLQRQFHVTGTQYISTDKVQSQTLNTGGTAETFSPWANKPRA
                     FFTIFIYQGQKVVRACFNLSHQTRRPTLGRISAAPFCPTLYWPTHSSEIYLFSGAFAGV
                     VVTLSAWKSALFRKISLSEPHLRRV"
     CDS             1495..2718
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg17_2"
                     /sec_met_domain="TPP_enzyme_C (E-value: 6.2e-49, bitscore:
                     156.5, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAELGSAEYPKNVNIRGYKPNTDVHIGQLKRAIKLLNKAKRPLFL
                     AGGGVVISRAHEIFREVVEKTKVPVVTTVMGKGSIPTDHPLYIGNLGMHGAYAANMAVS
                     NCDVLFSIGTRFNDRITGKLHEFAPHAQIIHIDIDTASISRNIQVDIPIVADAKEAITK
                     MNEYVQECSTDKWLNLIKNWKEEHPLKMRPNDLLSPMDILKEINEQFENSIIVTDVGQH
                     QMLVSQYAEITEGKQMIMSGGLGTMGYGLPGGIGAKIGNPDRPVIVISGDGGVQMNIQE
                     LATAVLEELPVILCIFNNEYLGMVRQWQKLFYGKRYAMTNLRAGALSRRTEGMEYPQYT
                     PDFIRLAESYRAKGIRVTKKEEIAAAFEEAKKNTKAPTVIEFIIDPEEMVYPMIKPGGT
                     LEDMIMDC"
     CDS             2736..3245
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg17_3"
                     /sec_met_domain="ALS_ss_C (E-value: 1.2e-22, bitscore:
                     70.9, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKGMKKRWISLYVENQVGVLSKISGLFSGKSYNLDSLTVGTTED
                     PTVSRMTIATVSDDETFEQIKKQLNRMIEVIKVIDFTDVFVRMKEILYIKVFNCSKEDK
                     VELFQIAETFKAKVIDYGKDSLLLEFVQTATKNDAVVKLIKEEFHRIEVVRGGSVGIES
                     ISMMER"
     CDS             complement(3314..4570)
                     /locus_tag="ctg17_4"
                     /transl_table=11
                     /translation="VKSTERLIFHIDVNSAFLSWESARRVSQGLPDLREIPSCVGGDPK
                     KRTGIVVAKSIPAKKYGIQTGEPVAMALRKCPNLVIVPSDFELYDKCSRAFKAICASFA
                     PVMESFSIDEVFLDMTGTSLIYPDPVAAAHELKGKIHRELGFTVNVGISTNKLLAKMAS
                     DFQKPDRVHTLFPDEIPEKMWPLPIRNLLFLGKASEQKLLNQGIRTIGDLARERASNVQ
                     YWLGEKTGHQLWQYARGIDDSPVKAVPDEAKGFSVETTFNDDITSIEQVFPILLEQCDV
                     LATRMRRKDKKCNCISVTFRTLDFRNRSHQTKLENATDLTDEIYINATRLFKEFWKGQP
                     LRLIGVALTGLTDGTYEQMSLFEDTENKERHRKLDAAMDEIRMKFGNDKITRASIMNSN
                     ARIGRKAKAQMKNEKMEEP"
     CDS             5333..6046
                     /locus_tag="ctg17_5"
                     /transl_table=11
                     /translation="MYLSDIHTHSIASGHGTTCTISDMAKAASKKGLKLLGISDHGPGT
                     LASGTSSYFRSLPFYPRKRFGIDILYGVELNILDSAGHTDLSDELLNNLDYAIISMHRQ
                     NYRSGSVSQNTEAYINAIKHPAVKILGHCDDTHFPVDYETLARAALRENVIFEINEASL
                     APGGYRGDTRANAARILYLCQKYQLPVILSSDSHGKEHVGDFTYAEEFVHQLMFPETLI
                     LNNQLPKLKVFLQTR"
     CDS             6248..6607
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg17_6"
                     /sec_met_domain="ALS_ss_C (E-value: 3e-23, bitscore: 72.8,
                     seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTIATVSDDETFEQIKKQLNRMIEVIKVIDFTDVFVRMKEILYIK
                     VFNCSREDKAELFQIAETFQAKVIDYGKDSLLLEFVQTATKNDAVVKLIKEEFHRIEVV
                     RGGSVGIESISMMER"
     CDS             6982..7617
                     /locus_tag="ctg17_7"
                     /transl_table=11
                     /translation="MNTTTTTTTAATKRSSTLYMVELAMMIAIILLMSFTPLGYLRTPG
                     LSITLLTIPVAVGAIILGPKGGAVCGLAFGATSFYMAVTGSSAFAAALFNINPFGTFIV
                     CIVARVLEGWITGLIFAALYKSPAKKFSYYVASLACPLLNTFFFMGFLCLFFYNTDYIQ
                     GIVSSLGVSNPVVFVAAFVGVQGLIEAGFCFVVGSIVSKALSVALKRA"
     CDS             7952..8707
                     /locus_tag="ctg17_8"
                     /transl_table=11
                     /translation="LSGGSAYGLAAADGVMHYLESQNIGYNTGAALVPLVCQSCIYDLS
                     YGDPKIRPTAKMGEEACRQAFAGTDTRTGNIGAGTGATVGKLYGMKQSMKSGLGIAAVS
                     VKNFQMAAIVVVNALGDIFSPQNGQKIAGLKTPDRSGFLDSVHELYRFMTPHDQFTGNT
                     TIGAVITNGAFSKAELNKIASMTRCAYARCINPVATMADGDSIYAASIGDVSVDINMAG
                     TLAAEVMAQAIQNAIHTSRIQDEEFLKYV"
     CDS             complement(8779..8931)
                     /locus_tag="ctg17_9"
                     /transl_table=11
                     /translation="MWPLPVRNLLFLGKASEQKLLNQGIRTIGDLAREREANVQLWLGE
                     KPEHR"
     CDS             complement(9120..10304)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MFS_1"
                     /gene_functions="transport (smcogs) SMCOG1058:Major
                     facilitator family (Score: 80.2; E-value: 4.6e-25)"
                     /gene_kind="transport"
                     /locus_tag="ctg17_10"
                     /sec_met_domain="MFS_1 (E-value: 2e-25, bitscore: 80.2,
                     seeds: 192, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKTNYNRTVQACFIGYVVQAIVNNFVPLLFLTLQGSYGISLQKIT
                     LLVTFNFGIQLLVDLASIGFVDRIGYRASMILAHAMAAAGLILLTVLPECLGDPFVGLL
                     IAVMIYAIGGGLLEVLVSPVVEACPTDNKEKAMSLLHSFYCWGHVGVVLLSTLFFRIFG
                     IANWKYMALVWALIPIANGIFFTRVPIAPLLDEGEKGLTMGELFKKKIFWVLMLMMLCA
                     GASEQAVSQWASTLAEKSFGINKTIGDLAGPMAFAILMGSSRAFYGKFGDKINLERFMQ
                     YSAVLCMVSYLMIAFIPVPALGILGCAVCGLSVGIMWPGTFSMAAASVKRGGTALFALL
                     ALAGDVGCSSGPTYVGMISGALNDNLKLGIFAALIFPVLMIMGIKMIGSLQKYD"
     CDS             complement(10617..11381)
                     /locus_tag="ctg17_11"
                     /transl_table=11
                     /translation="MLNQFSRTELLLGKEAMDKLENARVAVFGIGGVGGYVCEALVRSG
                     VGAFDLIDDDKVCLTNLNRQIIATRKTVGQYKTEVMRDRILDINPKADVRIHNCFYLPE
                     NAADFDFSEYDYVVDAVDTVTAKIELIMRAKEAGTPVISSMGAGNKLDASAFRVADIYK
                     TKVCPLAKVMRRELKKRGVKKLKVVYSEEQPIRPIEDMAISCRSHCICPPGAAHKCTER
                     RDIPGSVAFVPSVAGLIIAGEVIKDLTAEYRR"
     CDS             complement(11375..11575)
                     /locus_tag="ctg17_12"
                     /transl_table=11
                     /translation="VEQVMKRLVIKNKRKIWLWFLFIVLLILACRAAYVTGNKNMQIRD
                     EAVEEQQVENVVGQDKVERLC"
     CDS             complement(11575..12993)
                     /locus_tag="ctg17_13"
                     /transl_table=11
                     /translation="MRKTKIICTMGPSTDKGDVMEQLVREGMDVARFNFSHGPHDEQRG
                     RIQKLRELRKKYDRPVAALLDTKGPEIRLGCFKDGKVSLEEGQIFTFTNKDIEGTNECV
                     SITYKELYKDVQPGGHILVDDGLVDLEVQDISGKDIVCKVINAGVIGDKKGVNVPGANL
                     KMPFISKKDHDDLLFGIQEGFDFVAASFTRTANDIREVRKILKENGGEEIQIIAKIENQ
                     QGVDNIDEIIEAADGIMIARGDMGVEIPPEYVPVIQQKIIQKVYTAGKPVITATQMLDS
                     MISHPRPTRAEATDVANAIFQGTSATMLSGETAAGKYPVQALQMMSRIAEHMEQNIDYN
                     TIFKKTDRNENPDITNAIAHATCLTAIDLKASAILAVTKSGSTAHMMSKHRPGCLIGAC
                     TSSERVLRQLNLSWGVYPMLIKEEYSSEILCLRAIEAAQKHKLVKVGDTIVFAGGVPLG
                     IPGRTNLIRVCTVE"
     CDS             complement(13247..13777)
                     /locus_tag="ctg17_14"
                     /transl_table=11
                     /translation="MNYNRLETSLIDVIKEEQAKLGYMKEKISLYYPLSSLNHFFGNET
                     DAAGMMEILKDFPSYIEEKFGEVAVSHRGDRFCFTVSEKASEYVHNNMKENEFIKALIE
                     LVGRHGCTIEEIKELFHSYSDKIITEPMDNEEFDVMIRFDDGSDPYYYCFKDEGCHIIY
                     HRFLPEDYADFGF"
     CDS             complement(14109..15635)
                     /locus_tag="ctg17_15"
                     /transl_table=11
                     /translation="MAKETRIMGKRAAGILMPISSLPSDYGIGCFSKSAYEFVDWLKEA
                     GQTYWQILPLGPTSYGDSPYQSFSTFAGNPYFIDLDTLVEEGVLDKKDCEKVNWGKKPD
                     EVDYEKIYKGRYPLLRKAYENSDISKNPDYQKFVAENSWWLSDYALFMAVKDRFEGVEW
                     TKWAEDIRLRWNNAMDYYREELYFDIEFQQYMQFKFYEQWMKLKSYANSKGIQIIGDIP
                     IYVAMDSADAWAHPELFQLDQDNVPLAVAGCPPDGFSATGQLWGNPLYRWDYHRNTGYQ
                     WWISRMSYCFRLYDVVRIDHFRGFDEYFSIPYGDKDARGGHWEKGPGIDLFRKIEQALG
                     WKQVIAEDLGYMTDSVRHLVYESGFPGMKVLEFAFDSRDSGCASDYLPHNYPENCVAYT
                     GTHDNETIVGWWKSITAAERKLARDYLCDHATPEEELYKCFISLIMRSAARVCVIPMQD
                     YMGLDNRFRMNKPSTVGTNWKWRIKKRDLTKKLQKEIYDVTLRYGRKNWD"
ORIGIN
        1 tatttactca aagaatcaac tcctttcaat aatattctac tctaatatct tataaaactc
       61 aacatgtgct tatatgattt tataatttat atttaactgt taataacctt ccaaacatct
      121 gtattattta ttttttatat cagcaatata gaaatctgtc aattacatta ctgttcactc
      181 cgttctcagt aacgtagcca aaattcattc aggaacataa attttacagc aattatccaa
      241 aacccggttg acaatttcct ctctataaat gtataatgta acccaagaaa acatttgtcc
      301 accctattcg gacaatgaat atccctatat cagccaaatg ccatgacagg gaggagtaca
      361 caaccccggg aagcacagag agaaagcggt cggtgcgagc tttcgtgaac gaattgtgga
      421 agtagccccc gagcagtgaa ccaaaccgca tatccagtca gatgattcat agacccggac
      481 agacatgcca agtaggcttc aacgtcagtt ccacgttaca ggaacacagt atatcagtac
      541 tgacaaagtg cagagccaga ctctgaatac aggtggtacc gcggaaacat tttcgccctg
      601 ggcaaacaag cccagggcgt tttttactat atttatatat cagggtcaaa aagtcgttcg
      661 tgcttgcttt aatctgtcac atcaaacccg ccgccccaca ctcggcagaa tcagcgcagc
      721 gccattctgc cccaccctgt attggccaac acacagctcg gaaatttatt tgttttcggg
      781 tgcatttgca ggagtcgtag taactcttag tgcctggaaa tctgcgttgt tcagaaaaat
      841 ctcactgtct gagccgcatc tgcggcgagt ttgagatttt tctgaacggt tttagcagat
      901 tttcagacac ttagagttcc tagactccga aaccgcaccc gaaaacaaat aaatttccga
      961 gcgtccccat ccacataccc aaaggaggtt tacccaaata tgaaacaaat atccggcaac
     1021 aaactcttag tcaaagcctt aaaagaagaa ggcgtagaat acctcttcgg ctaccccgga
     1081 gcctgtacca tcgacatcag tgatgaactc tacaaacagg acgacgtcaa aatcatcctc
     1141 ccccgtcacg aacaggccct tgtccacgaa gcagacgcct acgccagaac caccggcaaa
     1201 gtcggcgtat gtctggtaac cagcggtccc ggagcaacca accttgtaac aggacttgca
     1261 accgccaact atgacagcgt acctcttgta tgcttcaccg gccaggtagc ccgccacctc
     1321 atcggcaacg atgcatttca ggaagtagac atcgtaggaa tcaccagaag catcaccaaa
     1381 tacggtgtta ctgtccgcag acgtgaagac ctgggacgta tcatcaaaga agccttctac
     1441 attgcccgca ccggccgtcc gggacctgtc cttatcgacc ttccaaagga cgtaatggca
     1501 gaacttggca gcgctgagta tcctaaaaat gtaaacatcc gcggatacaa gcccaacaca
     1561 gatgtccata tcggccagct caaacgtgcc atcaaacttt taaacaaggc aaaacgtcct
     1621 ttattccttg caggcggcgg tgtagtaatc tcccgcgccc acgaaatctt ccgggaagta
     1681 gtagaaaaaa caaaagtacc ggttgtcaca accgtaatgg gcaaaggttc cattcctact
     1741 gaccatccgc tttatatcgg aaacctcggc atgcatggtg cctatgcagc aaacatggca
     1801 gtcagcaact gcgatgtgct gttctccatc ggaaccagat tcaatgacag aatcaccgga
     1861 aaacttcatg aatttgcacc acatgcccag attatccaca ttgatattga tacagcatcc
     1921 atttcccgaa acattcaggt ggatatcccc attgttgctg atgcaaaaga ggctatcacc
     1981 aaaatgaacg aatacgtcca ggaatgttca acggacaagt ggcttaacct gatcaaaaac
     2041 tggaaagaag agcatccgct taaaatgcgt ccaaatgatc ttttaagtcc gatggatatc
     2101 ctgaaagaga tcaacgaaca gtttgagaac agtattatcg taacagatgt aggacagcat
     2161 cagatgcttg tctcccagta tgcggaaatc acagagggca aacagatgat catgtccggt
     2221 ggtctgggaa caatgggcta tggtcttcca ggcggcatcg gagccaaaat cggaaatccc
     2281 gacagacctg tcatcgttat ctccggtgac ggcggtgtgc agatgaacat tcaggagctt
     2341 gcaacagcag ttctggagga acttccagta atcctgtgta tctttaacaa tgaatatctt
     2401 ggaatggtac gccagtggca gaaactcttc tacggtaaac gctacgccat gaccaacctg
     2461 cgcgccggag cactttcccg ccgcacagaa ggcatggaat atccacagta cacaccggat
     2521 ttcatcagac ttgcagagag ctacagggca aaaggaatcc gtgtcacaaa gaaagaggaa
     2581 attgcagcag ccttcgagga agcaaaaaag aacacaaagg cacctacagt aattgaattc
     2641 atcattgacc ctgaggaaat ggtttatcct atgatcaaac caggcggaac tctagaagat
     2701 atgattatgg actgttgatc aggaggaaaa ttattatgga taaaggaatg aaaaaaagat
     2761 ggatttctct ctatgttgag aaccaggtag gtgttctgtc caaaatctcc ggacttttct
     2821 ccggaaaaag ctacaatctg gacagtctta ctgtaggaac caccgaggac cccacagtat
     2881 ctcgaatgac gatcgcaact gtcagtgatg atgaaacttt tgagcagatc aaaaaacagt
     2941 tgaaccgtat gatcgaggtt attaaggtta ttgatttcac agacgtattt gtccgcatga
     3001 aagagattct gtatattaag gtttttaact gttccaaaga agataaggtt gaactgtttc
     3061 agattgccga aaccttcaag gcaaaggtca ttgactatgg caaagacagc ctgctcctgg
     3121 aatttgtcca gacagcaacc aagaatgacg cagtagtgaa actgatcaag gaagaatttc
     3181 acagaattga agtggtacgt ggaggaagtg taggaatcga atctatcagt atgatggaac
     3241 gataaaactt tttctgaaat ttttataaag ggaggattgt cgcattgttc ttaatgctca
     3301 gtcctccctt tacttacggt tcttccatct tttcgttttt catctgtgct ttcgcttttc
     3361 gcccaatccg tgcattgctg ttcataatac tggcacgggt gatcttatca tttccaaatt
     3421 tcatccggat ctcatccata gctgcatcca gctttctgtg gcgttcttta ttttctgtat
     3481 cttcaaacag agacatctgt tcataagtgc catctgtaag gcctgtcagt gccacaccaa
     3541 tcagacgtag cggctgtcct ttccagaatt ctttaaaaag tcttgtagca tttatataaa
     3601 tttcatctgt aagatctgta gcattttcca gctttgtctg gtgtgaacgg tttctgaaat
     3661 ccaaagtacg gaaagtcacg gaaatacagt tgcatttctt atcttttctg cgcattctgg
     3721 ttgccagaac atcacactgc tccaaaagta tgggaaacac ctgctctatg gaagtaatat
     3781 catcgttaaa agtagtttcc acgctgaaac cttttgcctc atcaggcact gcttttacag
     3841 gggaatcatc gatacctctg gcatattgcc atagctgatg tcccgttttt tccccaagcc
     3901 agtactgcac attggatgct ctttctcttg ccagatcacc gatggtacgg attccctgat
     3961 tcagaagctt ctgctcggaa gcttttccca gaaacagcag attacggata ggaagaggcc
     4021 acattttctc cgggatttca tccgggaaca gagtgtgtac tctgtccggc ttttgaaaat
     4081 ctgatgccat ctttgccaaa agcttattgg tagaaattcc tacatttact gtaaatccca
     4141 gctctctgtg aatcttgcct ttcagctcat gagcagcagc tacagggtca ggatagatca
     4201 gagaagtacc tgtcatatcc agaaatacct catcaatgga aaaagattcc atcacaggtg
     4261 caaaggaagc acagattgct ttaaatgccc gggaacattt atcgtataat tcaaaatcac
     4321 tgggaacgat caccagattg ggacatttcc gaagagccat ggctactggc tcgccggtct
     4381 ggatcccgta tttttttgca gggatagatt tggcaaccac gatacctgtc cgtttctttg
     4441 gatctcctcc tacacaggaa ggaatttctc tgagatccgg cagcccctgg ctcacccttc
     4501 tggctgattc ccaggaaaga aatgcactgt tgacatcaat atgaaaaatt aatcgttccg
     4561 tacttttcac tgttcttcct ccaatatatg aattgcgctc ttcatatctg atgatttcat
     4621 tttaccctga tctgctctcc agggtaagaa cctcgtttgt ccaaaaaagt gtctttattt
     4681 acatcatctt gtctgagctg ttactgtatt tatatttgtt tgatttcact ctgctatcag
     4741 agttttgaac aacaacgccg cacttgccat acggcagtgc ggcgtctgta tttcgctacc
     4801 ggtcacattg ttcccggtaa ctttttttac ttaattctga ggattcattt cctctcgata
     4861 tatacttatc gattagtcat aaaggttagg agcaatttct tcgctgtcca tatttgtgga
     4921 atcataccag tatccagttc agcctccagc cattcataag agaattccgg gaatgtctga
     4981 tgtttgaaat ttttccatgt tactcctttc tcatgaagta actgtctaca cataagcaaa
     5041 cagtgccatc gctgtcattg atcagcaata agcccccgtg ttttcatata gttccattat
     5101 accttctcat tttcccgaag tcaacataat ttaacatgta tcagccgttt atttgtgttg
     5161 ctttttattt gatttttgtt gtatttcagt tgtttttatt ttgtttcctc attgacattt
     5221 aaatcctcat ctgtcatact tgaatataac gaatgtacca tcaaacagca gctttgcatc
     5281 ttccgtaagg ctcttatcat atatagaaac cgctctggaa aggagacaaa caatgtatct
     5341 ttctgacatc cacacacatt ctatcgccag cggtcacgga accacctgta ccatctctga
     5401 catggcaaaa gcagccagca aaaaaggact gaaactcctt gggatttctg accacggccc
     5461 gggaactctg gcttccggaa cttcttctta tttcagaagc cttccttttt atcccagaaa
     5521 aagattcggc atagatattc tttacggagt tgaactaaac atcctggaca gtgcaggaca
     5581 tacagatctg tcagatgaac tgctgaacaa cctggattac gctatcatca gtatgcatcg
     5641 gcagaactac cgttcaggct ctgtatctca gaatacagaa gcttacatca atgcaataaa
     5701 acatcctgct gtaaaaatac tcggccactg cgacgataca catttccctg tagattatga
     5761 aacgctggca agagcagctt tacgggaaaa tgttattttt gaaataaacg aagcttccct
     5821 cgcacccgga ggatatcggg gagacacaag agccaatgcc gccagaatcc tgtatctctg
     5881 tcagaaatat cagcttcctg ttattttgtc cagcgacagc cacggaaaag aacatgttgg
     5941 agatttcacc tatgccgaag aattcgttca ccagctcatg tttccggaaa ctcttatcct
     6001 taacaaccag cttcccaaat taaaagtttt ccttcagaca cgttaaaaga atgttcctca
     6061 aagggacatt cttttatttt atgcattgtt ttttgcattg tgttattttg tttattttct
     6121 ataatttctt atcaaaaaag atgatatttt agtacatttt aactaacaaa actcacttaa
     6181 ccatttacat atctcgtgat agatcagtct tactgtagga actaccgagg accccacagt
     6241 atctcgaatg actatcgcaa cagtcagcga tgatgaaacc tttgaacaga tcaaaaaaca
     6301 gttaaaccgc atgatcgagg ttatcaaggt aatcgacttc acagatgtat ttgtcagaat
     6361 gaaagaaatt ctctatatca aggttttcaa ctgctccagg gaagataaag cagaactgtt
     6421 tcagattgca gaaaccttcc aggcaaaagt cattgactat ggcaaagaca gtctgcttct
     6481 ggaatttgtc cagacagcca ccaagaatga tgcagttgtt aaactgatca aggaagaatt
     6541 ccacagaatt gaagtggtcc gcggtggaag cgttggaatt gaatccatca gcatgatgga
     6601 acgctaaatc tcataatcaa tattttttgc aggatataga aacacctcta tatcctgtat
     6661 ttattttcaa acatactata aaatattgca gtttttaatc aaatgtgtta ttgtttacgg
     6721 gagcgttatt cgaaagaaaa tgcatctgat ttccacatct gacagtctgg tggataaagt
     6781 catccacttc acagtctggt taaatttgtg aggcgacctg taaggcgtct acacaccgga
     6841 aacttttacc ggaagatatt tcttgtttca tatcttttgt tctgatgtat atttttcata
     6901 acgcctgatc cccatactct aaactgtctg aaaagcaggg gacgcattgc gccgttttat
     6961 cagaccaaaa ggagaattca tatgaacaca acaacaacta ctacaacagc tgccacaaaa
     7021 agaagcagca ctctttacat ggtagagctg gctatgatga ttgccattat tctgctcatg
     7081 tcctttaccc cgctgggcta ccttcgtact cccggcttat ccatcactct tctcaccatc
     7141 ccggtagctg taggagctat catcctcgga ccgaaaggtg gtgctgtatg cggacttgct
     7201 ttcggtgcaa ccagcttcta tatggctgtc acaggaagtt cagctttcgc tgccgcactt
     7261 ttcaacatca atccatttgg tacttttatt gtgtgtatcg tggcacgtgt gctggaagga
     7321 tggatcacag gacttatttt cgcagcatta tataaatcac cggcgaagaa attttcctat
     7381 tacgttgctt cactggcatg cccgttactg aatactttct tcttcatggg ctttttatgt
     7441 ctcttcttct acaacacaga ttacattcag ggtattgttt ccagtcttgg agtaagcaat
     7501 cctgttgtct tcgttgctgc ttttgtgggc gttcagggac tgatcgaagc gggcttctgc
     7561 tttgtagtgg gaagcatcgt ttccaaggca ctttctgtgg cactgaaacg tgcataatct
     7621 ttaaaagaac agccgtttac caaacaaccc tgactacatt gtcactgtag tcaggatttt
     7681 tttatccggc acatttaaag caggaaccct acctgattcg gttaatacaa aggagatttt
     7741 tatgtcatta ttaaaagaga tttctattac agatctttca aatttacgca tcggtcatgc
     7801 ttccgattat aatgcccaga ccggggtaac cgttctttac ttcccactgg gtgcaaaggt
     7861 tggctgtgat atcagcggtg gcggtcctgc ttccagggaa actcctctca cctctcctgt
     7921 cactgccgac aatcccatca atgctattgt cttgtccgga ggttctgcct atggactggc
     7981 tgctgctgac ggtgtgatgc actatctgga atcacaaaat atcggttata acaccggtgc
     8041 agccctggtt cctcttgtat gccagtcctg tatctatgac ctctcttacg gagatcctaa
     8101 aatacgtcca actgcaaaaa tgggcgaaga agcctgccgt caggcatttg caggaacaga
     8161 taccagaacc ggaaatatcg gtgcaggtac cggtgcaact gtgggaaaac tttacggtat
     8221 gaaacaatcc atgaagtcag gtcttggtat tgccgctgta tctgtgaaaa atttccagat
     8281 ggccgcaatt gtcgttgtca atgcactggg agatatcttc agtccacaaa atggtcagaa
     8341 aattgcaggg ctgaaaacac ctgacagaag cgggtttctg gacagtgtcc acgaattata
     8401 ccgctttatg acacctcatg accagtttac cggcaatacc accatcgggg ctgtgatcac
     8461 caatggggca ttttcaaagg ctgaactgaa taaaattgcc tctatgaccc gctgtgccta
     8521 tgccagatgc atcaatcctg tagcaactat ggctgacggc gattccatct atgctgccag
     8581 cattggcgat gtttctgtag atatcaatat ggcaggaact ctcgccgcag aagtcatggc
     8641 tcaggctatc caaaatgcca tccatacttc ccggatccag gatgaagaat ttctgaaata
     8701 tgtataacag tccgctataa aagcgcagag aaaaagtatc atctctgcgc ttttattctt
     8761 cctgtctgtc ttcatttttc atctgtgctc tggtttttct ccaagccaga gctgtacatt
     8821 tgcttcccgt tcccttgcca gatcaccaat agtacggatt ccctgattca gaagcttctg
     8881 ctcggaggct tttcccagaa ataacaggtt acggacagga agtggccaca ttttctccgg
     8941 tatttcgtcc gggaacagcg tgtgtactct gtccgtttct ttggatctcc tcccacacag
     9001 gagggaatct ccctgagatc cggcagcccc tggcttaccc ttctggctga ctcccaggaa
     9061 agaaatgcgc tgtttacatc aatatgaaaa attaatcgtt ccatactttt taatatatct
     9121 caatcatatt tttgcagact tccaatcatc ttaatcccca ttatcatcaa cacagggaaa
     9181 atcagtgccg caaagattcc aagtttcaga ttatcattca gtgctcctga aatcatcccc
     9241 acataggttg gtccggatga acatcccaca tctccagcaa gggcaaggag agcaaacaag
     9301 gctgttccgc cacgctttac tgaggcagcc gccatgctga aggttcccgg ccacataata
     9361 cctacagaca gaccgcaaac cgcacatcca aggattccca acgcaggtac cgggataaat
     9421 gcgatcatca gataggaaac catgcacaga actgcactgt attgcataaa gcgttccaga
     9481 ttgattttat ctccaaattt cccataaaat gcccttgaac ttcccataag aattgcaaac
     9541 gccatgggac ctgccagatc tccgatagtt ttattgattc caaagctttt ctcagccaga
     9601 gtagaagccc actggcttac cgcctgctca ctggctcctg cacagagcat cattaacatc
     9661 agaacccaga agattttttt cttaaaaagc tctcccatag tcagcccctt ttcaccctca
     9721 tccagcagtg gagcaatggg aactctggta aaaaagattc catttgcaat gggaatcaat
     9781 gcccacacca gcgccatata tttccagttt gcaatcccga aaatacgaaa gaataatgta
     9841 gaaagaagta ccactcccac atgcccccaa cagtaaaagg aatgaaggag actcattgct
     9901 ttttccttat tatctgtagg gcaggcttcc accacaggac ttaccagcac ctccagcaat
     9961 ccgcctccga tggcatagat cataactgca atgagaagtc ccacaaacgg atctcccagg
    10021 cactccggca atactgtgag caaaatcaga cctgcagccg ccattgcatg tgccaggatc
    10081 atagatgcac gataacctat tctgtccaca aatccaatcg atgccagatc taccagcaac
    10141 tggatcccga aattaaaagt aaccagaagt gtgatcttct gcagcgaaat cccgtaactg
    10201 ccctgaagtg tcagaaacag cagaggaacg aaattgttca caatggcctg cactacatat
    10261 ccgataaaac aggcctgcac tgttctgttg taatttgttt tcatccgatg ttatatcctc
    10321 caatctgaaa tttattaagc tgacatcatt cagacattga cctaccaaac ttctatatct
    10381 ccacagttct aatagatttc tatccgtcaa taatggcagt gtatcacaga ttctctcctt
    10441 tttctttcat tatcttttga aaatcccata aatttttata ttattttgac tttttcccta
    10501 taacaattct ataaaatcca aaagtaatac ccccatccga ttccaaatat ttcccgcaaa
    10561 aaaagatgtg caccatacca tttctgacac catacacatc tcaaaataaa cacttcttat
    10621 cttctgtact ctgcagtcag gtctttaata acctctcctg caataatcag cccggcgaca
    10681 gacggcacaa acgccacact gcccggaata tctctgcgct ccgtacactt atgcgcagca
    10741 cccggaggac aaatacaatg cgatctgcag ctgattgcca tatcttcaat cggtctgatc
    10801 ggctgttctt ccgaataaac aaccttcagt tttttcacac cacgcttctt cagctctctg
    10861 cgcataacct tcgccagcgg gcacaccttc gtcttataga tatctgccac ccgaaatgca
    10921 ctggcatcca gcttatttcc ggcacccata ctgctgataa caggagtccc tgcctctttt
    10981 gcacgcatga tcagttcaat cttcgcagtc actgtgtcca cagcatctac cacataatca
    11041 tactcactaa aatcgaaatc agcagcattc tccggaagat aaaaacagtt atggattctc
    11101 acatctgctt tcggattaat gtccaagatc ctgtcccgca tcacctctgt tttatattga
    11161 ccaacagttt tcctggtggc aataatctgt ctgttaagat tcgtcaggca tactttgtca
    11221 tcatcgatca gatcaaaggc ccctacgccg cttctgacca atgcttcaca tacataacct
    11281 ccaactcctc cgattccaaa tactgccaca cgggcattct ccagtttatc catcgcttct
    11341 tttccaagaa gaagctcagt tctcgaaaat tgattcagca taatctctcc actttatcct
    11401 gtcccactac attctctacc tgctgttcct ctactgcctc gtctcttatc tgcatattct
    11461 tatttcccgt gacatacgca gccctgcatg ccaagatcag aagcacgata aacagaaacc
    11521 agagccagat ttttctttta ttttttatga ctaaccgttt cataacctgc tccactattc
    11581 tactgtgcag acgcggatca ggtttgttct tcccggaatt ccaagcggta caccaccggc
    11641 aaatacaata gtgtcgccaa cttttacaag tttatgcttc tgtgctgctt cgattgctct
    11701 caggcaaagg atctcagaac tgtattcttc tttgatcagc atcgggtaaa caccccagga
    11761 cagattcagc tggcgaagaa ctctctcaga gcttgtacat gcaccgatca gacatcctgg
    11821 tctgtgtttg gacatcatat gagctgtact tccggatttt gtcactgcaa ggattgcact
    11881 ggccttcaag tcgattgcgg tcagacaggt tgcatgtgcg attgcatttg taatatccgg
    11941 attctcattt ctgtctgttt tcttaaagat tgtattgtaa tcaatattct gctccatatg
    12001 ttctgcaata cggctcatca tctgaagtgc ctgtaccgga tatttaccag ctgcggtttc
    12061 tcctgaaagc atagttgcac ttgttccctg aaaaatcgca ttggcaacgt ctgtagcctc
    12121 tgcacgggtt ggtctcggat gagagatcat ggagtcaagc atctgtgttg ctgtaataac
    12181 cggttttcct gctgtgtaaa ctttctggat gattttctgc tggataacag gtacatattc
    12241 cggcgggatc tcaacaccca tgtcacctct ggcgatcatg atgccatctg ctgcttcaat
    12301 aatctcgtcg atattgtcaa cgccctgctg gttctcaatc tttgcaatga tctgaatctc
    12361 ttcaccgccg ttttctttca ggatttttct tacttcgcgg atatcgtttg cagtacgtgt
    12421 aaaagatgct gcaacgaaat caaatccttc ctggataccg aagagaagat catcatggtc
    12481 ttttttactg atgaatggca tcttcaggtt tgcacccgga acattgacac ccttcttgtc
    12541 gccaatcaca cctgcattaa taaccttgca gacaatgtcc tttcctgaga tgtcctgaac
    12601 ctccaggtct acaagtccat catcaaccag aatatgtcca cccggctgca catccttata
    12661 aagctcttta taagtaatgc ttacgcactc attagttcct tcaatatctt tatttgtaaa
    12721 tgtaaaaatc tgtccttctt ccagagaaac cttgccatcc ttgaagcatc caagtctgat
    12781 ctccggtccc ttggtatcaa gaagtgctgc aacaggtctg tcatatttct tgcgaagttc
    12841 tctcagtttc tggatacggc ctctctgctc atcgtgaggt ccatgtgaga agttgaaacg
    12901 tgctacgtcc attccctctc tcacaagctg ctccataaca tcgcccttat cagtagacgg
    12961 tcccattgta cagataattt tggtttttct catttaatct ttccctccaa actgtcaact
    13021 caattttatc tattttattc ctgtaaaata atgtaataaa atgttacctg tttctataaa
    13081 tgaaaacatt aaatcaaata aaaattacca ttattgagac tatctgtcaa tatagaattt
    13141 cgacttattt ttgttgatat ttgacaaaaa aataacatac ttttgttgca aatgtcacat
    13201 atatttttgc cgatccgaca gttggaaaat ttttcactca ttcttatcag aatccaaaat
    13261 ctgcatagtc ttccggcaga aatctgtggt aaatgatatg gcatccttca tctttaaaac
    13321 aataataata aggatctgat ccatcatcaa agcggatcat cacatcaaac tcctcgttat
    13381 ccattggttc agtaatgatt ttatctgaat aagaatggaa cagttcttta atttcctcta
    13441 tcgtacatcc atgtctgcca accagttcga tcaatgcctt gataaattca ttctctttca
    13501 tattattatg tacatattcg gaagcttttt ccgaaacagt gaagcagaaa cgatctcctc
    13561 tgtgtgatac tgctacttca ccaaatttct cttctatata agaaggaaaa tcttttaaaa
    13621 tctccatcat gcctgcagca tccgtctcat tgccaaagaa atgattcagg gaactgagcg
    13681 gataataaag gctgatcttc tccttcatat atccaagctt cgcctgttcc tctttgatca
    13741 catcgatcag actggtttct aatctgttat agttcattta ttttccctcc tgaaaatcta
    13801 tccttttgct ttttctggtt aatattttat cagacattgc ccgaaaatca atgcatttct
    13861 ttttcaattg tacgcccgcc aaaacaattt caatgttttc tttttcatac aaaaataaag
    13921 agcttgcgaa actgtccttt ttttctccct ctgacaaata actctgactg gataaaacaa
    13981 aacagataaa accaaccact tcgttgcttt tttaaccaaa taactgcttg attcggttaa
    14041 aaaaacagcg ttccgaatat tatttatatc cgaaacgctg tcattattcc aattatttca
    14101 ttatgtattt aatcccaatt cttacgtccg taacgaagtg tcacatcata tatttccttc
    14161 tggagtttct ttgtaagatc tctcttcttg attctccact tccagttcgt accaactgta
    14221 gatggtttat tcattcggaa tctgttgtcc agtcccatat agtcctgcat tgggataacg
    14281 cagacacgcg cagcactgcg catgatcaga ctaatgaaac atttatacag ttcttcttcc
    14341 ggtgttgcat gatcacacag ataatctctc gccagttttc tctcagctgc tgtgatgctc
    14401 ttccaccatc ccacgatagt ttcattatca tgggttcctg tatatgccac gcagttctcc
    14461 ggataattat gtggcagata atcactggca catccggaat ctctggagtc aaacgcaaat
    14521 tccagaacct tcattcccgg gaagccgctc tcatatacca gatgacgtac agaatctgtc
    14581 atatatccta agtcctctgc gataacctgc ttccatccaa gcgcctgttc gatcttacgg
    14641 aacagatcaa ttccgggacc cttttcccag tgtccgcctc ttgcatcttt atctccgtat
    14701 ggaatagaga aatattcatc aaatccacgg aaatgatcga ttcgcacaac atcatacagt
    14761 ctgaagcaat aactcattct ggaaatccac cactgatatc ctgtatttct gtgataatcc
    14821 cagcgatata acggatttcc ccataactga ccggttgcag aaaatccatc cggagggcat
    14881 cctgctactg ccagtggtac attatcctga tccagctgga acagctccgg atgcgcccat
    14941 gcatcagcac tgtccattgc aacataaatc ggaatatctc caatgatctg gattcctttt
    15001 gaatttgcat aggatttcaa tttcatccac tgctcataga acttaaactg catatactgc
    15061 tggaattcaa tatcaaaata gagttcttca cgataataat ccatggcatt gttccagcgg
    15121 agtctgatat cctcagccca tttggtccat tctacacctt cgaaacggtc ttttactgcc
    15181 ataaacagag cataatctga cagccaccag ctgttctctg ctacgaattt ctgatagtca
    15241 ggattcttgc tgatatcact gttctcgtat gcttttctca gaagaggata acggcctttg
    15301 tagatttttt cataatctac ctcatcaggc ttctttcccc aattaacttt ctcgcagtct
    15361 ttcttatcaa gaactccttc ttccacaagt gtatccagat caataaaata tggattacct
    15421 gcaaatgtag agaaagactg atatggagaa tctccatagc tggtcggtcc caatggcaga
    15481 atctgccagt aagtctgtcc ggcttccttt aaccagtcta caaattcata tgcacttttg
    15541 gaaaaacatc cgatgccata gtctgatgga aggctgctga tcggcattaa tattcctgct
    15601 gctctttttc ccatgattct tgtctccttc gccattcttc acttttaccg cctatacttt
    15661 atctagtgta tatataagca gtttttctat accttatgcg caattgtttt ttttattata
    15721 tctatttttt gtgcaaattg caatacaact ttcatgttat ccattttttc gtgaaaatta
    15781 ctaatcattg cttatttctt ttcgtcatct tccatattaa acaccaatca tttccactca
    15841 gagcattgtc gtcaagcgga tattcgcaat ctgcttcgct acgcagctct ataccgaata
    15901 actgctccgc atttcatcag aaggagctta ttttttatcc atatcaaaaa cttataatta
    15961 caatgcaata tttctatttt acgtttcatt tctgatatga taggatgtgt tcagttaaaa
    16021 aacaacaaag taacactcca acttatctgt tgagaaacgt ttatcattaa ctaccatcag
    16081 aaaatttctt atacagatat cttcaacatc ttaagttata cacatcaaag acaaagaaag
    16141 aggtaagaaa atggaagaca acaaattatg tctggaaaag cagcctttaa atcaggaaat
    16201 gcttgacaaa atcgatgctt actggcgtgc agctaactat ctgtctgccg gacagctcta
    16261 tcttcttgac aatccgcttc tgagagagcc attaactatg gatcagatca agaaaaaaat
    16321 tgttggtcat tggggaactg taccgggaca gaacttcgtt tatgcacact gcaaccgtgt
    16381 catcaaacgt tatgaccttg atatgatcct gctttccggt cctggacatg gcggaaactt
    16441 catgattgcc aatacctatc tggaaggttc ctacagcgaa gtttatccta acatcagcca
    16501 ggatgaggaa ggtatgaaga aaatgttcaa acagttctcc ttcccatgcg gagtcccaag
    16561 ccactgcgca ccggaaacac ctggttccat taatgaaggt ggcgagc
//
