LOCUS       c00054_gnlPro..        15313 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|LNBCGMOJ_54.
ACCESSION   c00054_gnlPro..
VERSION     c00054_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-05 01:25:34
            Original ID  :: gnl|Prokka|LNBCGMOJ_54
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15313
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15313
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[8838:12087]"
                     /cutoff="10000"
                     /detection_rule="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /neighbourhood="10000"
                     /product="Putrescine2spermidine"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      8839..12087
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /neighbourhood="10000"
                     /product="Putrescine2spermidine"
                     /protocluster_number="1"
     cand_cluster    1..15313
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /kind="single"
                     /product="Putrescine2spermidine"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..15313
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Putrescine2spermidine"
                     /region_number="1"
                     /rules="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /tool="gutsmash"
     CDS             complement(2..130)
                     /locus_tag="ctg54_1"
                     /transl_table=11
                     /translation="LEKTNEKSLDILYNLCIKNNLFVRAYKLYPKYRREEDMTDNGK"
     CDS             complement(211..1098)
                     /locus_tag="ctg54_2"
                     /transl_table=11
                     /translation="MKKLRTFAVSMIIAAIGLLIYCAGFYIKSYEQNLAARQEYAELSQ
                     MAGVKNREGAGLLADGKKTDEDSRTKNSEKKRRKKQRRSSESKNKNCTDEIRESFGISW
                     ENLRKINSQTVAWITVPGADISYPVVQAADDEYYLKHNFRGEEDLFGCIFLEHDIKKNF
                     TDSHSILYGHNIEGNMMFANLNRYEQPEFLKKCPEIEITTPKRKFLYKIFSVEQASSQS
                     PAFEYGYKLSSPAYRRQLSILKNNSMYDTGVEPDERERMVTLITCNSRLDKEIRMAVHG
                     ICHECYGIEKAGPK"
     CDS             complement(1095..5804)
                     /locus_tag="ctg54_3"
                     /transl_table=11
                     /translation="MKHNFKLKERLGALLLAMLFILQAILGLVPVCVTQAAPLTVETWD
                     SDKVVDYGYRFNMKFQPGITTYESFGCDNLDREAFSDNGKSERDTECVRVGADYKAGSA
                     GMRYNNVGKDGNGNIVDVRLILVGVENAEPRYDLRTAESIVQNKGGATFAWKDNEAYPM
                     VGFSKNSIGVFIYSVGYAKVKFQFLKHGTEETLPISGHGTIRDIDAGQGVRIPSDSSLD
                     NAYVLKNNDYLTVDGNSVSSPLGSVEPDDPRGWLNLFYNTDNFTVEFCHQFRLDKWDKS
                     REDAIAKAGSQERWAEITRNKYLDPSGNSYCPNFKGQKYCKAYAYFDFTSYCFGDVEMK
                     KAPEKRVGEANCTWEQAAAASKEKPFGIRQGQEFQYMIRAEVTPNRLKSFVVQDILEDC
                     LTIEDASKVSIVNDAGQTVTDWFDVAVEGQKVTCRAKAESLQDEAFTDNQTYTFTLKVR
                     QRPESEINISKYLAEDGYSILVPNHASMSYERTNGSGDTMDTETVWVKGVIPPELEVKK
                     NTSQYEWKTGDIIDYEVLVSQTKQDVKAVNVVITDELPSCLQFLEGQYAVETSQGGENC
                     TLTGQGENGWKAECPSLKYGETITIRFKCQASAESNGQEWENIVTATADNLINPETGEQ
                     ESRKDMAEVWPNSPQLEIDKTADKYEWQAGEQVAYRIVVNNVTAGTIAKDVTITDIGLP
                     QGLVLAGGAQSMEVLGVQQQVNYPVPDKKTGQAYEARPVDSQLNADENGFSFYCSYVPY
                     SQPVTIIFHCIAQEEANGHESVNAATVKAANTDERSDDAEVYVNSGEFWIEKSADHYEW
                     QVGEQVQYNVVVENKKAGTVARNVTVWDTGMPAGLALSSAEDVSVSGIPQNITQLTAGT
                     KDVLNQLNPEFYNETSEKPVNYEFLQEGSGWRLNISDLPANTPVMISFLCTVTEAANGM
                     ESINVANVQAQNAPVSQDDAEVYVNTAVLSIEKSFQNPYLAAGDGRAENEFRVGEQVNY
                     QVTVNNLQKGSIARNLVISDLSLPEGLALDGAEDAVTVSGVPAVVQNPVAGTDDAGNQL
                     NPENYKETVEKPVSCQVTRQGTGWIVTISDLPYQTPVTVNFRCTAQESVNGMEIVNTAQ
                     AYADNAQKVKDSSKIWVNSPVLKVEKTTDKPFYKYGDIITYRIVLTQEQTGCVARNVTL
                     QDVIDTQGVRLLKDSVILMDEKGNVADADVQINDDNTFLMSTGRTLVRDSRYSICDNDK
                     GGLFEQVMYNPLDCQEQKSMIVEYQAAVIDAALAGQKVHNTAVADSSEKIPATGETETE
                     VHSPILEIVKESDKKEYAPGEKGYYKLTVRQLREDVTDQNIVIEDKLETQGASIVKDSI
                     FVKKNGIELKDAKIEADDTGFVIQTGASLSDMDKIEVCYEVVFKTESTEPEKIVNTAKA
                     RGDISPEIAAQQEVYVKTKAEPTATPTPSATPKPTETPKPTETPKPTEVPKPTEQPKAT
                     PTPSVPGTCPKMTPVPTKAPLASYNGGNNGGTTSGSGGSSYANSGGYSGGYGSYQGGSM
                     AGSSKTGDVRPFKMMAVLGLIGMGLLTGGVVIYRRTVSGKRNIKGMPRK"
     CDS             complement(6007..6468)
                     /locus_tag="ctg54_4"
                     /transl_table=11
                     /translation="MNRKEFLEILRSQLAGQMQEGKAAAHIRYYEDYIQSQVRGGRSEQ
                     EVLQELGAPHLIAKTLIDTDDGSTQEDYGEYSSYGSSYGNETELPHQQEKRWKKVIDLS
                     TWHGRAVVIAAAAVIIVLLILIIGVAIPFFIILAIILYFLSWLKKRNDQ"
     CDS             complement(6720..7598)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) CN_hydrolase"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg54_5"
                     /sec_met_domain="CN_hydrolase (E-value: 1.2e-56, bitscore:
                     181.4, seeds: 52, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRNVTVAAVQMKCSKSVEKNIAHAEELVRQAAAKGAEIVLLPELF
                     ERPYFCQERRYEYYEYAQTAEENPAVRHFSRVAAELGIVIPVSFYEKEVNNTYNSVAVL
                     DADGKNLGIYRKTHIPDDHYYQEKFYFTPGDTGFKVFDTRFGTIGVGICWDQWFPETAR
                     CMALQGAELLFYPTAIGSEPILECDSMEHWRRCMQGHAASNLIPVIAANRIGEETVEPC
                     PENGMQKSALNFYGSSFITDNTGALCAELPGGEEGVLVSTFDLDALKADRLNWGLFRDR
                     RPEMYAKIVGK"
     CDS             complement(7701..8891)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PAD_porph"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg54_6"
                     /sec_met_domain="PAD_porph (E-value: 5e-128, bitscore:
                     416.3, seeds: 436, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VRLSDISGTKTLRAGFPDICRAIKEKETDMEVTEKNRTKYRMPGE
                     FEPHEGCVMIWPERPGSWNYGAREAQKAFVKVAEAIGVSEKVYMLVSKAQMENAKNQLG
                     NVSGVTLLECETDDAWARDVGATMVLDEKGAVCGVDWQFNAWGGDFDGLYRNWEKDDRV
                     AAFICRTVGCPCLDARPFVLEGGSIHSDGEGTLIVTEACLLSQGRNPQMSREQIEEQLK
                     YWLGVHKIIWLPCGIYQDETNEHVDNVCAFVRPGEVVLAWTEDETDPQYAMSLADLKVL
                     EQETDAKGRKFKIHKLPIPQKPVCLTREDVDGFVFEEGEDERKAGERMAASYVNFYISN
                     GGIILPQFGDENDKRAVEILQKCFPERRIYPIDARAIIVGGGNIHCITQQIPGKNI"
     CDS             complement(8839..9960)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Orn_DAP_Arg_deC"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg54_7"
                     /sec_met_domain="Orn_DAP_Arg_deC (E-value: 3e-15, bitscore:
                     45.9, seeds: 500, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIDQLQTPCYVIDEKKMRENLEILKKVQEDTGCKILLAQKAFSG
                     FALYPMIGKYLAGTTASGLFEARLGYEEMGKENHVFSPAYRTEDIEELDRICDHIIFNS
                     TAQLKKFKEVCTGASLGLRINPECSTQGDHAIYDPCAPGSRLGVTRENFDGECLKWIDG
                     LHFHTLCEQNADDLEKTLQAVEEKFGEFLSEVSWLNMGGGHHITREDYDVKLLEKCIQH
                     MKETYDLDIYLEPGEAVALNAGYLVTEVMDIVENGIRTLILDASAACHMPDVLEMPYRP
                     PLKDSGEAGEKAYTYRLSSCTCLAGDVIGDYSFDREIRIGDKLYFMDMAIYSMVKNNTF
                     NGMPLPDIAVMHEDGECEVIRHFGYEDFKSRLS"
     CDS             complement(9950..11230)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Sacchrp_dh_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Sacchrp_dh_NADP"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg54_8"
                     /sec_met_domain="Sacchrp_dh_C (E-value: 4.2e-44, bitscore:
                     141.1, seeds: 375, tool: rule-based-clusters)"
                     /sec_met_domain="Sacchrp_dh_NADP (E-value: 2e-36, bitscore:
                     114.7, seeds: 81, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSRLLVIGCGGVASVAIRKCCQNSDVFTEIMIASRTKEKCDALKE
                     KIESTTKTKIETAKVDADNAAEVAELIRAYKPDAVLNVALPYQDLTIMDACLEAGADYI
                     DTANYEAEDTEDPTWRAIYEKRCKEKGFTAYFDYSWQWAYDEKFKEAGLTALLGTGFDP
                     GVTSVFSAYALKHYFDEIHTIDILDCNGGDHGYPFATNFNPEINLREVSANGSYWEDGH
                     WVETEPMEFKSVYDFPEVGKKDMYLLHHEEIESLAKNIPGVQRIRFFMTFGQSYLTHMK
                     CLENVGMLSTAPVEFNGQEIVPIQFLKALLPDPASLGPRTVGKTNIGCIFTGVKDGKEK
                     SIYIYNVCDHQECYKEVESQAISYTTGVPAMIGSMMVVTGQWKKPGVFNVEEFDPDPYM
                     EALNKWGLPWKVCEDPELVKVWKANED"
     CDS             complement(11227..12087)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Spermine_synth"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Spermine_synt_N"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg54_9"
                     /sec_met_domain="Spermine_synth (E-value: 3.4e-54,
                     bitscore: 172.6, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="Spermine_synt_N (E-value: 5.1e-16,
                     bitscore: 48.0, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MELWYSEFHTGNVKLSVRINRQLFSGESEFQRIDVFESEEFGRFV
                     ALDGEIVFSDKDEFIYDEMVTHVPMTVHPNVKNVLIIGGGDGGVARELIHYPQIESIDV
                     VESDKMFVDVCAEMFPDIAQGLKDERVNIYYEDGLRFLRNKKARYDLIINDSTDPLGHT
                     EGLFTKEFYGSCYKALRDDGIMVYQHGSPFYDEDEVECRKMHRKVFRSFPVSRVYQAHI
                     PTCPSGYWLFGFASKKYHPLEDFRPERFDNLNIETWYYTTNLHRGAFMLPKYVEDLLEE
                     EENSL"
     CDS             complement(12090..13547)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) OKR_DC_1_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) OKR_DC_1_7_arginine"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg54_10"
                     /sec_met_domain="OKR_DC_1_C (E-value: 2.8e-14, bitscore:
                     43.2, seeds: 113, tool: rule-based-clusters)"
                     /sec_met_domain="OKR_DC_1_7_arginine (E-value: 6.1e-127,
                     bitscore: 413.0, seeds: 39, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDYERQQHAPIYEALERFRKKRVVPFDVPGHKRGRGNPELAQLLG
                     EKCVGLDVNSMKPLDNLCHPVSVIREAEELAADAFGAAHAFLMVGGTTSAVQSMILSVC
                     KAGDKIILPRNVHKSAINALVLCGAIPVYVNPEVNAQLGISLGMEVSQVEKAMDENPDA
                     VAVLVNNPTYYGICSDLRTIVKKAHARGMKVLADEAHGTHLYFGRNLPVSGMAAGADMA
                     AVSMHKSGGSLTQSSLLLLNKSMNAEKVRQIINLTQTTSASYLLLSSLDISRRNLALRG
                     EESFEKVAGMAQYAREEINEIGGYYAYGMDLINGTSVFDFDVTKLSIYTLGNGLAGIEV
                     YDLLRDEYDIQIEFGDICNILAYISIGDRLQDIERLVGALADIERLYKKDSTGMLSGEY
                     IAPAVVASPQQAFYAEKESLPMEQAAGRISGEFVMCYPPGIPILAPGEMVTQEIVEYIL
                     YARDKGCSMQGMEDPKVERLQVLKGGI"
     CDS             14773..15312
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) FTHFS"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg54_11"
                     /sec_met_domain="FTHFS (E-value: 2.6e-95, bitscore: 309.1,
                     seeds: 408, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGFKSDIEIAQECEMLPITQIAEKAGIDDKYLEQYGKYKAKIDYN
                     LLKESDKKDGKLILVTAINPTPAGEGKTTTTVGLADGMQRLGKSVMVALREPSLGPVFG
                     VKGGAAGGGYAQVVPMEDINLHFTGDFHAIGAANNLLAAMIDNHIFQGNALNIDPRKIT
                     WRRCVDMNDRQLRNVVD"
ORIGIN
        1 gctttccatt atctgtcatg tcttcttccc tcctgtattt aggatacaac ttgtacgcac
       61 gtacgaacaa gttgtttttt atgcataaat tatacaaaat atcgagagat ttttcattag
      121 ttttttccaa aacacctcga gggatagtga tatgtgaaca gtaacagttc atcctttacg
      181 aaagttacca atatccgatt gatttcaaca tcacttcggc ccagcttttt ctataccata
      241 acattcatgg caaatcccat gtaccgccat acgtatttct ttatccagac gtgaattaca
      301 ggtgatcaga gtcaccattc tctccctttc atcaggctct actcctgtgt catacatgga
      361 attatttttc aatatagata attgtctcct gtatgcagga ctggataact tgtatccata
      421 ttcaaatgcc gggctttggg aagatgcctg ttccacagaa aaaattttgt acagaaactt
      481 tctttttggt gttgtgatct caatttcagg acattttttc agaaattcag gctgttcata
      541 acggttcaga tttgcaaaca tcatattacc ttctatatta tgcccgtaaa gaatactgtg
      601 ggaatctgta aaattctttt ttatgtcatg ttccagaaaa atacatccaa acagatcttc
      661 ctctcctctg aaattatgtt tcaggtaata ttcatcatct gccgcctgaa ctacaggata
      721 agaaatatcg gctcccggga cagtaatcca ggcaactgtc tgagagttga tttttcttaa
      781 attttcccag gaaatcccga aggattccct gatttcatct gtacagtttt tgttttttga
      841 ttcagaagat cttctctgtt ttttcctgcg ttttttttca ctgttttttg tcctgctgtc
      901 ttcatcagtt tttttgccat ctgccaataa tccggcacct tctctgttct tcacccctgc
      961 catttgggaa agctctgcat attcctgcct tgctgcaaga ttctgttcat aactttttat
     1021 atagaaaccg gcacaatata taagaagccc aattgctgct atgatcatac ttactgcaaa
     1081 tgttctgagt tttttcattt ccgcggcata ccctttatat ttcttttccc ggaaacagtt
     1141 cttctgtaga tcaccacacc tcctgtcagc agtcccattc cgataaggcc aagaacagcc
     1201 atcattttaa acggtctgac atctcctgtt ttagaacttc ctgccatgga accaccctga
     1261 tagcttccgt atccaccgga atatccaccc gaatttgcgt aactgctgcc tccgcttccg
     1321 gaagttgtgc ctccattatt tccaccattg taagatgcca acggtgcttt cgtcggtaca
     1381 ggagtcattt tcgggcaggt tcccggtaca gatggtgttg gtgtggcttt tggctgctcc
     1441 gtcggtttcg gtacttctgt aggttttggt gtctctgtcg gctttggtgt ttctgttggt
     1501 ttcggtgttg cagacggtgt tggtgtggca gtgggttctg cttttgtttt cacatatacc
     1561 tcctgctgcg ccgcaatttc cggtgaaata tctcctcttg ctttcgctgt gtttacaatt
     1621 ttttcaggct ctgtgctttc tgttttaaat accacttcat agcagacttc aattttatcc
     1681 atatctgaca acgatgctcc tgtctgaatt acaaatcctg tatcatctgc ctctattttg
     1741 gcatctttca gctctatgcc gtttttcttc acaaaaatgc tgtcttttac aatagaagcc
     1801 ccttgggttt ccagtttatc ttcgataaca atattctgat ctgtgacatc ctcacgcagt
     1861 tgtcttactg tcagcttata gtatcctttc tcaccgggcg catactcttt cttatctgat
     1921 tccttcacaa tttccagaat cggactgtgt acctctgtct ctgtttcccc ggttgcaggt
     1981 atcttttcac tgctgtctgc aactgcagta ttgtgcactt tctgtcctgc cagggctgca
     2041 tcaatcactg ctgcctgata ttccacgatc atacttttct gttcctgaca gtccagagga
     2101 ttatacatta cctgctcaaa aagaccgcct ttatcattat cgcagatact atatctgctg
     2161 tccctgacca gtgtcctgcc tgttgacatc aggaaagtat tatcatcatt gatctgtaca
     2221 tcagcatctg ccacatttcc tttctcatcc atcagaatca ccgaatcctt cagaagacgt
     2281 actccctgag tatcgatcac atcctgcaga gtaacattac gcgccacaca tccggtctgc
     2341 tcctgtgtca ggacaatgcg gtatgtaata atatcaccat atttgtaaaa tggtttgtcc
     2401 gtcgtcttct ctactttaag aacaggcgag ttcacccaga tttttgagga gtcctttact
     2461 ttctgtgcat tatctgcata cgcctgtgct gtatttacaa tctccatccc atttacgctt
     2521 tcctgcgcag tacagcggaa attaacagtc acaggtgtct gatacggaag atctgaaatc
     2581 gtcacgatcc atccggttcc ctgacgtgta acctgacagc tgaccggttt ttccactgtt
     2641 tctttataat tttccggatt cagctgattt cctgcatcat cagttcctgc caccggattc
     2701 tgaacaacag ccggaacacc gcttacagta acagcatctt cagctccgtc cagagccagc
     2761 ccttcaggaa gggaaagatc actgatcaca agatttcttg cgatagatcc cttctgaaga
     2821 ttattaaccg taacctgata attcacctgt tctcctaccc gaaattcatt ttccgcacgt
     2881 ccgtccccgg ctgccagata tggattctga aaacttttct caatagaaag aactgctgta
     2941 tttacataca cttctgcgtc atcctgtgaa acaggggcat tctgcgcctg cacattggca
     3001 acattaatgc tttccattcc atttgccgct tccgtaactg tgcaaaggaa agaaatcata
     3061 accggagtat ttgccggaag atctgaaatg ttcagtctcc atccgcttcc ctcctgaaga
     3121 aattcataat tcaccggttt ctctgatgtc tcattataaa attccggatt gagctggttc
     3181 aaaacatctt tggtccctgc tgtcagctgc gtaatattct gtgggattcc gcttaccgat
     3241 acatcctctg ccgatgaaag cgcaagtcct gccggcatac cggtatccca gacagttacg
     3301 ttccgggcca ctgtacctgc ttttttattc tccaccacca cattgtactg tacctgttct
     3361 ccgacctgcc attcataatg atctgcagat ttctcaatcc agaattctcc tgaatttaca
     3421 tatacttctg catcatcaga tctctcatct gtattagcag cttttacagt tgctgcattt
     3481 acgctttcgt gtccatttgc ctcttcctgt gcgatacaat ggaaaataat cgttacaggc
     3541 tgactgtatg gcacataaga acaataaaag gaaaatccgt tctcatctgc attcaactga
     3601 gaatccacag gtctcgcttc atatgcctgt cctgttttct tatccggtac gggatagttt
     3661 acctgttgtt gaactcccag tacttccatg ctctgtgcac cacctgccag aaccagtccc
     3721 tgcggcagac caatatcagt aatagttaca tcttttgcga ttgttcctgc cgttacatta
     3781 ttcactacga tccggtaagc tacctgctct cctgcctgcc attcatattt gtctgctgtt
     3841 ttatcaattt caagctgtgg actgttcggc catacttctg ccatatcctt tctggattcc
     3901 tgttctcctg tctcaggatt gatcagatta tccgctgttg cagtcacaat attttcccat
     3961 tcctgtccat tggactccgc agatgcctga catttaaaac ggattgtgat cgtctcccca
     4021 tacttcaggg acggacactc tgctttccat ccattttctc cctgtccggt aagcgtacag
     4081 ttctcgcctc cctgacttgt ctctacagca tactgccctt ccagaaactg cagacatgat
     4141 ggaagctcgt ctgtaataac aacatttact gcttttacat cctgttttgt ctgagaaacc
     4201 agaacctcat aatctatgat atctcccgtt ttccattcat actgagaagt atttttcttt
     4261 acttccagtt ccggtggaat cacacccttt acccacactg tttccgtatc cattgtatct
     4321 ccgcttccgt ttgtacgttc ataactcatg gatgcatggt ttggtacaag aatactgtat
     4381 ccatcctctg caaggtattt tgaaatgtta atttctgatt ccggtctctg gcgtactttt
     4441 aaagtaaatg tgtaagtctg attatctgta aatgcttcat cctgaaggct ctctgctttg
     4501 gccctgcagg tcactttctg tccttcaaca gcaacatcaa accagtctgt cactgtctgc
     4561 cctgcatcat tcacaatact gacttttgat gcatcctcta tagtaagaca atcctcaagt
     4621 atatcctgta ccacaaagga tttcagtcta ttgggtgtca cctctgcccg gatcatatac
     4681 tgaaattcct gtccctgacg aatgccaaaa ggtttttctt ttgatgcggc agctgcctgt
     4741 tcccatgtac agtttgcctc tcccacacgt ttttcaggcg cttttttcat ctcaacatca
     4801 ccgaaacaat aggatgtaaa atcaaaatat gcatatgctt tgcagtattt ctgtccttta
     4861 aagttcggac aataactgtt gcctgatgga tccagatatt tatttcttgt aatctctgcc
     4921 catctttcct gagaaccggc ttttgcaatg gcatcttcac gacttttatc ccatttatcc
     4981 agtctgaact gatgacagaa ttctaccgta aaattatctg tattataaaa aagattcagc
     5041 catcctctcg gatcatccgg ctcaacggaa ccaaggggtg agcttacaga attcccatct
     5101 accgtcagat aatcattgtt tttcagaaca tatgcattat ccagactgct gtctgacgga
     5161 atacggactc cctgtcccgc atcaatatca cgtatggttc catgaccact gatcggcagt
     5221 gtttcttctg ttccatgctt cagaaactga aacttaacct ttgcgtatcc tacagaataa
     5281 ataaatacac cgatactgtt tttggaaaaa ccaaccatcg gataagcttc attatctttc
     5341 caggcaaacg tagctccgcc tttattctga acaatcgatt ctgcagtgcg cagatcataa
     5401 cggggttctg cattctctac tcccacaaga atgagtctga catcaacaat atttccattt
     5461 ccatcttttc ctacattgtt ataacgcatc cctgcgcttc cggctttata gtccgctcct
     5521 acacgaacgc actctgtgtc acgttcgctt tttccattgt ctgaaaaagc ttccctgtcc
     5581 agattatcac acccaaaaga ttcatatgtg gtaattccgg gctgaaactt catgttaaag
     5641 cgataaccat aatctaccac cttgtcactg tcccatgttt ctacagttaa cggtgccgcc
     5701 tgagttacgc agacaggcac aagccccaga attgcctgca gaataaaaag cattgcaagc
     5761 agcaaagctc caaggcgttc tttcagtttg aaattgtgtt tcattttccg tctcctttcc
     5821 gaacaaaaaa tataaaaatg aatgtgggat ttttccctgc accaggcagg attaaagaat
     5881 agaaataagt tgaaatgtat gattataaat attcaagggg aattaatatc gtgaaacaag
     5941 aacgtttaca cttaagattt ttaagattct gcgcagggtt ccttttctga aaccctgcac
     6001 agattttcat tgatcatttc ttttcttcag ccatgaaaga aaataaagaa taattgcaag
     6061 aataataaaa aacggaatcg caactccgat tatcagtatc agtaaaacaa ttataacagc
     6121 cgccgctgca ataacaacag ccctgccatg ccaggtagaa agatcgatta cttttttcca
     6181 tcttttctcc tgctgatgag gaagctctgt ctcattgcca taactgcttc cgtaagaaga
     6241 atactctccg taatcttcct gtgtacttcc atcatctgta tcgatcagag tttttgctat
     6301 cagatgcggg gctcccagtt cctgcagtac ctcctgctct gaacgtccac cacgtacctg
     6361 agactgtata taatcttcat aatacctgat atgtgccgct gctttgcctt cctgcatctg
     6421 cccggcaagc tggcttctca ggatttccaa aaattctttt ctgttcatct tctacactcc
     6481 attttgccag aaatacatgt caaaactcta ctgctctctc cgttatcagt aacgttcgta
     6541 ctcttatttt accatatata ccgcaggtag caactaatat aatcataaac tttttatgaa
     6601 attcttataa actcagttac tgttcactcc gttctcagta actgagccaa aattcgttcc
     6661 agattgcctg cggcaatgga attttgtagt ggtgtgtgaa caataactaa actcatacat
     6721 catttcccga caatttttgc atacatttca ggtctgcggt ctctgaaaag tccccagttc
     6781 agtctatctg cctttaatgc atccaggtca aaagtgctta caagcacccc ctcttcccct
     6841 ccgggcagtt ctgcacagag agcacctgtg ttgtctgtga taaaagagga accataaaaa
     6901 ttaagagcag atttctgcat tccattttcc ggacatggct ctactgtttc ctcaccgatt
     6961 ctgttggcag cgatcacagg gatcaggttg gaggcagcgt gtccctgcat acatcttctc
     7021 cagtgttcca tgctgtcaca ttccaggatg ggttcacttc cgatggcagt gggataaaag
     7081 agaagctctg cgccctgcag tgccatacat cttgccgttt ccgggaacca ctgatcccag
     7141 cagattccaa ctccaatggt tccaaatctg gtatcaaaaa ccttaaagcc ggtatctccc
     7201 ggtgtgaaat agaatttttc ctgataataa tggtcatccg gaatatgtgt tttccgataa
     7261 atgccgagat tctttccatc tgcatccaga accgcaacgc tgttataagt attattgacc
     7321 tctttttcat aaaagctgac cggaatcaca atccccaact ctgccgctac cctgctgaaa
     7381 tgacgcactg cagggttttc ctctgcagtc tgcgcatatt cataatactc atatctgcgc
     7441 tcctggcaga aatagggccg ttcaaaaagc tctggaagaa gaacaatctc agctcccttt
     7501 gctgctgcct gacgcaccag ttcctctgca tgggcaatat ttttctccac acttttactg
     7561 catttcatct gaactgctgc cactgttaca tttctcatcc tgtctgttcc tcctgctcct
     7621 gtttacataa gtaagttttt tcataacttt caggtaatac ccctcaaaca catgactctc
     7681 aaagtttttc tgcatcaagg tcagatattt tttccgggaa tctgctgggt aatacagtga
     7741 atatttccac cgccgacaat gatggctctg gcatcaatgg gataaatcct tctttcagga
     7801 aaacacttct gcagaatctc cactgccctt ttgtcatttt catccccaaa ctgtggaagg
     7861 ataatcccac cattggaaat atagaaattc acataactgg cagccatccg ttctcctgct
     7921 ttccgttcgt cttctccctc ttcaaacaca aagccatcca catcttcccg ggtaaggcag
     7981 accggtttct gaggaatcgg aagcttatga atcttaaatt ttctgccttt tgcatctgtt
     8041 tcctgttcca gcaccttcag atcagccaga gacatggcat actgcggatc tgtctcatcc
     8101 tctgtccatg caagcacaac ctctccgggc cttacaaaag cgcacacgtt atccacatgc
     8161 tcattggttt catcctgata gattccacat ggaagccaga taatcttgtg gacaccgagc
     8221 cagtacttca actgttcctc tatctgttcc ctgctcatct gaggattgcg tccctgactc
     8281 agaagacagg cctctgtaac gatcagagtc ccctctccgt cagaatggat ggaaccgccc
     8341 tcaagcacaa aaggtctggc atccagacat ggacaaccaa cagtcctgca gataaaggca
     8401 gccaccctgt cgtccttctc ccagttccgg taaagtccat caaagtctcc tccccaggca
     8461 ttaaactgcc agtcaactcc acagaccgcc cctttctcat ccagaaccat ggttgctccc
     8521 acatctctgg cccaggcgtc atctgtctcg cattccagca aagtcacacc ggaaacattc
     8581 ccaagctgat tctttgcatt ctccatctga gctttggaaa ccagcatata caccttttcg
     8641 ctcactccaa tagcctctgc aactttcaca aatgctttct gtgcttccct tgccccataa
     8701 ttccaggaac cgggacgttc cggccagatc atcacacatc cctcatgagg ctcaaattct
     8761 ccgggcatac gatattttgt tctgttcttc tctgtaactt ccatgtctgt ctccttttct
     8821 ttgatagccc ggcagatatc aggaaagccg gctcttaaag tcttcgtacc cgaaatgtct
     8881 gataacctca cactctccgt cctcatgcat aaccgcaata tccggcagcg gcataccgtt
     8941 aaatgtatta ttcttcacca tagaataaat cgccatatcc ataaaataca gcttgtcccc
     9001 gatccggatc tctctgtcaa aggaataatc tccgattaca tctcctgcca ggcaggtgca
     9061 ggaagataag cggtaggtat atgccttctc ccctgcttcc ccgctgtcct taagaggcgg
     9121 acgatagggc atctccagca catccggcat atggcaggct gcagaagcat ccaaaatcag
     9181 cgttctgatt ccattctcca caatgtccat aacctctgtc accagatatc cggcattcag
     9241 ggcaacagcc tccccgggct ccagataaat atccagatca taggtttcct tcatatgctg
     9301 aatacatttt tccaggagct ttacatcata atcctctctg gtaatatgat gtccgccgcc
     9361 catattcagc caggaaacct cagatagaaa ttctccaaac ttctcctcta ccgcctgcaa
     9421 tgttttctcc aggtcatccg cattctgttc gcagagcgta tgaaaatgca gtccgtcgat
     9481 ccatttcaga cattccccgt caaagttctc tctggtaacc cccagcctgg aacccggcgc
     9541 acagggatca tagatcgcat gatccccctg agtggagcat tccggattaa tacggagtcc
     9601 cagactggct ccggtacaca cttctttaaa tttcttcagc tgtgctgtgg aattaaagat
     9661 aatatggtca cagatacgat ccagttcttc tatatcttct gtacggtaag caggggaaaa
     9721 aacatgattc tctttcccca tctcttcata tccaagcctt gcctcaaaca gaccgctggc
     9781 agtggtacct gccagatatt ttccgatcat gggatacagg gcaaagccgg aaaacgcttt
     9841 ctgcgccaga aggatcttac acccggtatc ctcctggact tttttcaaaa tctccagatt
     9901 ctccctcatc ttcttctcat cgatcacata gcagggagtt tgcagttgat caatcttcat
     9961 tggctttcca gacctttacc agttcaggat cttcgcagac tttccatgga agtccccatt
    10021 tgttcagtgc ttccatatat ggatccggat caaattcttc cacattaaat acacccggct
    10081 tcttccactg tccggtcact accatcatgg aaccgatcat agccggaaca cctgttgtat
    10141 aggagattgc ctgggattcc acctctttat agcattcctg atgatcacat acattataaa
    10201 tataaatact tttctctttt ccgtccttaa cacctgtgaa aatacagccg atatttgttt
    10261 tacccactgt tctcggaccc agagatgcag gatccggcag aagagctttc aaaaactgga
    10321 tcggcacgat ctcctgtcca ttaaattcca caggtgcggt ggaaagcatt cctacatttt
    10381 ccagacattt catatgtgtc agatagctct gtccgaatgt cataaagaaa cggatcctct
    10441 gtactcccgg aatatttttt gccagtgatt caatctcttc atgatgaaga agatacatat
    10501 ccttctttcc tacctcaggg aaatcgtaga cagatttaaa ttccataggc tctgtttcta
    10561 cccaatgtcc gtcttcccag taggaaccat ttgcggaaac ctctcgaaga ttgatctccg
    10621 ggttaaagtt tgtggcaaaa ggatatccat gatcaccgcc gttacagtcc agaatatcaa
    10681 tggtatggat ttcatcaaaa taatgcttca aggcataggc actgaataca ctggtaacac
    10741 ccggatcaaa accggttccc agaagagcag tcagtcctgc ttccttaaat ttctcatcat
    10801 aagcccactg ccaggaataa tcgaaatatg cagtaaagcc tttttcttta catctctttt
    10861 cgtagattgc acgccatgtg ggatcttctg tatcctctgc ttcataattg gcagtatcaa
    10921 tataatccgc accggcttcc agacatgcat ccatgatggt aagatcctga tatggaagtg
    10981 ccacattcag gacagcatcc ggcttatagg ctctgatcaa ttctgcgacc tctgctgcat
    11041 tatccgcatc tacctttgct gtctcaattt ttgtcttcgt tgtactttca atcttctctt
    11101 tgagtgcatc gcatttttcc tttgtcctgc ttgcgatcat aatctctgta aaaacatcgc
    11161 tgttctgaca gcatttgcga attgccactg aagctacccc accacatccg attaccaata
    11221 atctgctcat aaactgtttt cctcctcttc cagtaaatct tctacatatt ttggaagcat
    11281 aaatgctcct ctgtgaagat ttgttgtata ataccatgtt tctatattaa gattatcaaa
    11341 cctctccggc ctgaaatctt ccagtggatg atatttcttt gatgcaaatc caaaaagcca
    11401 gtatcccgag ggacaggtag ggatatgtgc ctgataaacc ctgctcaccg gaaatgaccg
    11461 gaaaaccttt ctgtgcatct ttctgcattc cacctcatcc tcatcataaa aaggacttcc
    11521 atgctgataa accataattc cgtcatctct gagagcctta taacagcttc cgtagaattc
    11581 ctttgtaaaa agtccctctg tatgtcccag cggatctgtg gaatcattga tgatcaggtc
    11641 atatctggcc tttttattcc gcaggaaccg aaggccgtct tcataataaa tgttgactct
    11701 ctcatccttc agtccctggg caatatccgg aaacatctcc gcacatacat ccacaaacat
    11761 tttatcggat tccaccacat caatgctctc aatctgtgga taatggatca gttctctggc
    11821 aactccaccg tcaccgccgc cgatgatcag aacatttttt acattgggat gtactgtcat
    11881 tggcacatgc gtaaccatct catcataaat aaattcatct ttatcagaga atacgatctc
    11941 accgtccaga gccacaaatc ttccaaattc ttcagactca aacacatcga ttctctgaaa
    12001 ttcactttcc cctgaaaata actgtcggtt aatccggaca gaaagcttta catttcctgt
    12061 atggaactcg gaataccata attccatgat cagatacccc ctttcaggac ctgaagacgt
    12121 tctaccttcg gatcctccat tccctgcatg gaacagcctt tgtctcttgc ataaagaatg
    12181 tattctacaa tttcctgtgt caccatttct ccaggagcaa gaatcgggat tcccggagga
    12241 taacacataa caaattcacc gctgatcctg cctgccgcct gttccatggg cagagattct
    12301 ttctccgcat aaaatgcctg ctgtggagac gccaccactg caggtgcgat atattccccg
    12361 gaaagcatac ctgtgctgtc cttcttatac agacgttcaa tatcagccaa tgcccctacc
    12421 agtctctcaa tatcctgaag cctgtctccg atggaaatgt aagccagaat attacagata
    12481 tctccaaact cgatctgaat atcatattca tctctgagaa gatcataaac ttcaatacct
    12541 gccagcccat ttcccagtgt ataaatagag agttttgtaa catcaaaatc aaaaacactg
    12601 gttccattga tcagatccat accatatgca taataaccgc cgatctcatt gatctcctct
    12661 ctggcatact gcgccatccc tgcaaccttt tcaaaggatt cctctcccct gagtgccaga
    12721 tttcttctgg agatatccag actggacaac agaagataag aagcgcttgt ggtctgagtc
    12781 agattgatga tctggcgcac tttctctgca ttcatactct tattcaaaag cagcagcgaa
    12841 ctctgtgtca gacttccgcc ggatttgtgc atggaaactg ccgccatgtc agcacctgcc
    12901 gccattccgg atacaggaag gtttctgccg aaataaagat gggttccatg agcctcatct
    12961 gccagcacct tcattcctct tgcatgagcc ttctttacga tagtccgcag atccgaacag
    13021 attccataat aggtagggtt atttacaaga actgccaccg catccggatt ctcatccata
    13081 gccttctcca cctgactgac ttccatgcca agggaaatgc ccagctgcgc attcacctcc
    13141 gggtttacat aaaccggaat tgcaccgcac agtaccaggg cattgatggc acttttatgt
    13201 acatttcgcg gcagaatgat cttatcccct gccttgcaga cagacaggat catgctctgc
    13261 actgcagatg tggttcctcc taccataagg aatgcatgcg ctgcgccaaa agcatctgct
    13321 gcaagctcct ccgcttctct gatcaccgaa accgggtggc agagattgtc cagcggcttc
    13381 atagaattaa catccagccc cacacatttc tctcccagca actgtgcaag ctccggattt
    13441 cctcttcctc ttttatgtcc cggcacatca aagggaacga ctctcttctt tcggaaacgt
    13501 tccagtgctt catatatggg cgcatgctgt tgtctttcat aatccatttg acatgttcct
    13561 cttttcctgt cgtcatgtac cggcaaatac agttctatca ttcagcaatt gtatactgcc
    13621 tcaaaccggc acaatgattc aattatttct atatatattt gctatatctg cacaaaaaaa
    13681 gaagcagata agttcattca ccatctgctt ctctcatgat ctatagaatt tctcaggctc
    13741 tgtctcttta tatactgacc ggatttcccg tataaatccg tctgtatcct gtgcctgttc
    13801 ccgtattctg aaatattcat gactgctgtc gtcttcaatc gctggcaaat atatgctatg
    13861 ctcttattga ccgtttcaca agatgatgtg tgcttacgca ctgattatta taaagtaatc
    13921 aacttataaa atttgagctt ctaactcaat caataatgtg gtgtctccca cccggcaact
    13981 gccccgcctg tccgtatggc ttaacattca gaaactgtct ctgaatgtga gcaaatattt
    14041 gcatgaaaac gatagtgtct tttcatacta aagatgagaa taacatatct tctgaactgt
    14101 tgtcaattcc attttccata ttttgcacta gagcgtgtct gaaaaaggct ttctgcaaga
    14161 tgtgcgtcac aatttgtggg atattttgcc cggatgaggg cgccgtagcg ggctacggca
    14221 actgaattcg ggtgaaatat cccgcaaagt gggggcgtac agattgcggg aatgattttt
    14281 cagacacgct ctagctttac ccgcttttta tattttcttc atttatcagg gaaaaatgtg
    14341 tttatttttt aacaatttct tcccttgaga aaacgtattt tctttcatta ccagggatta
    14401 cgattctctt ctcttatcaa tttgcacaac ttttatccag tttactcaca ttttttgacg
    14461 tttcagcaaa aattttcttg acattttttt ctcaaaatga tatattgtat tcatcaattg
    14521 aaagaacctt cgagtactga cggaaagagt ggagtgcaaa ccacgtggag tcggaggttt
    14581 gtgggagccg accgtctggg cagtatttga aatattcaga tactggcctt tttttataac
    14641 tttcagggca gaaatcagga ataccaggca gaccggccaa tacttctttc aattaataat
    14701 tgttgctgat cgcggagtga acagcaacag aagtttttca tgttatgcgg aaacgaaagg
    14761 agaaaaacaa ttatgggatt caaatcagac attgaaattg cacaggaatg cgagatgctt
    14821 ccaattactc agatcgcaga gaaagcaggt attgacgaca aatatctgga gcagtacgga
    14881 aaatacaaag caaaaatcga ctacaatctt ctgaaagaaa gtgataagaa ggacggaaaa
    14941 ttaatcctcg ttacagctat caacccaact ccagcaggag aaggtaaaac tactactact
    15001 gtaggtcttg cagatggtat gcagagactt ggcaagagtg ttatggtagc tcttcgtgag
    15061 ccatccttag gaccggtatt cggtgtaaaa ggtggtgcag caggcggcgg atatgcacag
    15121 gttgttccta tggaagatat taaccttcac ttcacaggtg acttccatgc cattggcgca
    15181 gctaacaact tactggcagc tatgatcgat aaccatatct tccagggcaa tgcattaaac
    15241 atcgacccac gtaagatcac atggagaaga tgtgtagata tgaacgaccg tcagcttcgt
    15301 aacgtagtag atg
//
