LOCUS       c00057_gnlPro..        14109 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|LNBCGMOJ_57.
ACCESSION   c00057_gnlPro..
VERSION     c00057_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-05 01:25:34
            Original ID  :: gnl|Prokka|LNBCGMOJ_57
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14109
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14109
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[2058:6300](+)"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /neighbourhood="10000"
                     /product="Others_HGD_unassigned"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      2059..6300
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /neighbourhood="10000"
                     /product="Others_HGD_unassigned"
                     /protocluster_number="1"
     cand_cluster    1..14109
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /kind="single"
                     /product="Others_HGD_unassigned"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14109
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Others_HGD_unassigned"
                     /region_number="1"
                     /rules="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D, HleuD1,
                     HleuD2, HleuS1, HleuS2, Lactoyl-CoA1, Lactoyl-CoA2]) and
                     minimum(1, [ACP_syn_III, ACP_syn_III_C, AcetylCoA_hyd_C,
                     AcetylCoA_hydro, Acyl-CoA_dh_1, Acyl-CoA_dh_2,
                     AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG, Biotin_lipoyl,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_6_Glutaconate, CoA_transf_3, ECH_1, ECH_2, ETF,
                     ETF_alpha, FGGY_C, HCDH, HCDH_N, Hacid_dh, Hacid_dh_C,
                     Mal_decarbox_Al, Peptidase_M22, Peptidase_M23, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and not (minimum(2,
                     [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /tool="gutsmash"
     CDS             complement(134..433)
                     /locus_tag="ctg57_1"
                     /transl_table=11
                     /translation="MDASSGMGMVGAIVWMVVLFGIMYFLMLRPQKKEQKRLQAMLNDM
                     EVGDSIVTTSGFYGVIIDMTEEDVIVEFGNNKNCRIPMRKQAIAEVEKAGSAAE"
     CDS             complement(491..619)
                     /locus_tag="ctg57_2"
                     /transl_table=11
                     /translation="MMYSDALIRLLCMKTRFHTEGNGDYKWIAKQLFSMSSRQDGL"
     CDS             complement(682..1833)
                     /locus_tag="ctg57_3"
                     /transl_table=11
                     /translation="MAEYKLLKTEGRAKRAEFHTVHGTIQTPVFMNVGTIGAIKGAVST
                     MDLQQIGTQVELSNTYHLHVRPGDKIVKQLGGLHKFMVWDKPILTDSGGFQVFSLAKLR
                     KIKEEGVYFNSHIDGHKIFMGPEESMQIQSNLASTIAMAFDECPSSVADRDYVQKSVDR
                     TTRWLARCKAEMARLNSLPDTINKEQLLFGINQGAVYEDIRIEHAKAISEMDLDGYAVG
                     GLAVGETHEEMYRILDAVVPYLPQNKPTYLMGVGTPANILEGVERGIDFFDCVYPSRNG
                     RHGHVYTNHGKMNLFNAKYELDTRPIEEGCQCPACQHYSRAYIRHLLKAKEMLGMRLCV
                     LHNLYFYNHMMEEIRDALDAGNFAEYKKMRLEGFEEGKINSKR"
     CDS             2059..6300
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: BcrAD_BadFG"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: HGD-D"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg57_4"
                     /sec_met_domain="HGD-D (E-value: 8.2e-64, bitscore: 205.8,
                     seeds: 370, tool: rule-based-clusters)"
                     /sec_met_domain="BcrAD_BadFG (E-value: 8.5e-38, bitscore:
                     119.8, seeds: 18, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNYKTLGIDIGSTTVKIAILDENENLIFADYKRHFANIQETLADL
                     LQEAFDQYGEMTLHPVITGSGGLTLANHLGVPFTQEVIAVSTSLQKLAPKTDVAIELGG
                     EDAKIIYFENGNVEQRMNGICAGGTGSFIDQMASLLQTDATGLNEYAKDYKALYPIAAR
                     CGVFAKTDIQPLINDGATKPDLSASIFQAVVNQTISGLACGKPIRGHVAFLGGPLHFLS
                     ELRESFIRTLKLDEEHTIIPENSHLFAAIGSALNAKEDNSISLTEMKDRLRNSIKLDFE
                     VERMEPLFASQEEYDAFAKRQSSYKVKTGDLATYKGNCYLGIDAGSTTTKTALVGEDGT
                     LLYSFYSSNNGNPLKTTIRSIKEIYELLPEDAKIAYSCSTGYGEALIKAALILDEGEVE
                     TVSHYYAAAFFDPEVDCILDIGGQDMKCIKIRNKTVDSVQLNEACSSGCGSFIETFAKS
                     LNYTVQDFAKAAVFAQHPIDLGTRCTVFMNSKVKQAQKEGAEVSDISAGLAYSVIKNAL
                     YKVIKVSDASELGKHIVVQGGTFYNDAVLRSFEKIAGCEAIRPDIAGIMGAFGAALIAR
                     ERHQEGAETTMLSIDKINELKYTTSMANCRGCTNNCRLTINKFSGGRQYVSGNRCERGI
                     GKEKNKDHIPNLYEYKYKRIFSYTPLTADKATRGKVGIPRVLNMFENYPFWYTFFTELK
                     YEVVLSPTSTRKIYELGIESIPSESECYPAKLAHGHVTWLIRNGVKFIFYPCIPYERNE
                     FPDAVNHYNCPIVTSYAENIKNNVDELNDPSITFRNPFLAFTSEEILANRLVEEFKDIP
                     AGEVKAAVHKGWEEMAAARRDVQKKGEETLKYLEDTGRHGIVLAGRPYHIDPEIHHGIP
                     DLINSYGIAVLTEDSISHLAPVERPIRVNDQWMYHSRLYAAANYVKTRDDLDLIQLNSF
                     GCGLDAVTTDEVYEILDGSDKIYTCLKIDEVNNLGAARIRIRSLIAAIRAKKAQGQKRT
                     VKPASIDKVSFTKEMRKDYTILCPQMSPFHFSLLQAAFNSCGYNLEVLPNDNKHAVDVG
                     LKYVNNDACYPSLIVVGQIMDALLSGKYDLNKTAVVMSQTGGGCRASNYIAFIRRALKK
                     AGMEQIPVISVNLSGLESNPGFKLTLPLVKKVAYGAVFGDILMKCVYRMRPYELEEGIV
                     NRKHKIWEQRVISFLSGSSISHSQFKKMCREMVHEFDTIPISDVKKPRVGIVGEILVKF
                     LPAANNHLAELLESEGAEAVVPDLIDFMCYCFYNQNFKVENLGFKKSKATMANWGIKAI
                     EWVRKPASEALAQSRHFAPPADIRDLAKMASPIVSTGNQTGEGWFLTGEMMELIHGDVP
                     NIVCIQPFGCLPNHIVGKGVIKEIRREYPTANIVAIDYDPGASEVNQLNRIKLMLSTAQ
                     KNLKKAEEKNA"
     CDS             6326..6523
                     /locus_tag="ctg57_5"
                     /transl_table=11
                     /translation="MYFTLQYIRLRACLKNALRKMCVTICGRFCSDEGVVAGYDNRIRT
                     KYTAKHFSNALKKRVIFQKF"
     CDS             complement(6593..8179)
                     /locus_tag="ctg57_6"
                     /transl_table=11
                     /translation="MIAAMISKVIGLLYKSPLSNIIGSLGMGYTSLAQNAYMILLMIAS
                     FSIPQAVSKLISERIALKDYRNAHKFFKGAMIYAMVIGGVVGLFCLFGAGLIIPQNQKD
                     AIPALQILAPTIFLSGILGVFRGYFQAYRNMMPTSISQIIEQVFNAAVSLLAAWGFINA
                     FSDGTENSIAKWGAAGSTVGTGAGVVTALAFMLLVYGVNRRKILHRVERDHRHQEESYK
                     EIFRVIILVVSPIILSAFVYNVNAYINGYLFSDILGRRGGDAAQIGILYAEYATYFMTI
                     INIPLTLSSTAPTSMIPEVSALYATGDIEATRECIDQTVQLSMVVSAPCAMGLAVLAQP
                     IVFLLYGNSTGLAANLLILGSFSILLNGMSNISNGVLQAIGQQRIPVITAAIALVVDIV
                     VVVVLLFTTNLGVYALLIAMVIYSVVVCVLNDRAMKKYLQYKNPWKEGYLYPVLASVPM
                     GIVAGCICYGLNIFVKSNFICLIVSIPVAAVVYLFAYLIISKPSESQLRRIPGGSYLIR
                     IAEKLPFWQNN"
     CDS             complement(8267..8941)
                     /locus_tag="ctg57_7"
                     /transl_table=11
                     /translation="MSAISGDWLEALKGEFHQPYYAKLYKTVMTEYQTRKIFPPADDLF
                     NAFHFTPLNEVKVVILGQDPYHNDGQAHGLCFSVKRGVETPPSLVNIYQELHDDCGCYI
                     PNNGYLEKWAKQGVLLLNTVLTVRAHQANSHRGIGWEQFTDAAIQVLNEQDRPIVFLLW
                     GRPAQMKKSMLNNPKHLILEAPHPSPLSAYRGFFGCKHFSKTNEFLVANGLEPIDWQIE
                     NI"
     CDS             complement(8974..9732)
                     /locus_tag="ctg57_8"
                     /transl_table=11
                     /translation="MFTKRIIPCLDVNNGRVVKGVNFVQLRDAGDPVEIAKAYDAAGAD
                     ELVFLDITASCEQRDTVVDMVRRVAANVFIPFTVGGGIRTVDDFKKLLREGADKISVNS
                     AAIDRPELISEAADKFGSQCVVVAIDAKRREDGGWNIYKHGGRLDTGIDAIEWAKKVEA
                     LGAGEILLTSMDCDGTKAGYDLALTRAIADAVSIPVIASGGAGTLEHFYDALTEGGADA
                     ALAASLFHYKELEISQVKDYLSDRGISVRR"
     CDS             complement(9734..10372)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GATase"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg57_9"
                     /sec_met_domain="GATase (E-value: 4.1e-31, bitscore: 97.8,
                     seeds: 97, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIAIIDYDAGNIKSVEKALHYLGEETTVTRDPQTLLNADKVILPG
                     VGSFGQAMENLHTYGLVPVIHEIVEKKTPFLGICLGLQLLFESSEETPGVEGLGILKGK
                     IVKIPPAPGLKIPHMGWNSLHFQNNGRLFQGIPEQTYVYFVHSYYLQAEEPEIVKATTE
                     YSTCIHASVEKDNVFACQFHPEKSSKWGLKILENFAAVGKDGNTEKEGK"
     CDS             complement(10618..12162)
                     /locus_tag="ctg57_10"
                     /transl_table=11
                     /translation="MTGTGKTDKKFHTLQHQISVVFICLLLLSIFTITLINGLFLEKYY
                     VSKKVEVLEEAKEVLSQMNLDDILQYDTDIEEDKKGATDEISDEIERSSSRNNLTWIIV
                     NEENSGYYYWGENNMAKMLRSKLFGYINNLDQDMQHSRVLKKTDTCTMWQVHDRFAGME
                     YVECWGQFDNGYYFLIRSPLESIKESASISNSFYFIVGIIIIVISGIVILVMTNRITRP
                     ISELTKLSEKMSDLDFDARYQSRAGNEIDVLGDNFNKMSRKLESTISELKSANNKLQKD
                     IEDKIKIDEMRKEFLDNVSHELKTPIALIQGYAEGLNENISDDPESREFYCEVIMDEAS
                     KMNKLVKNLLTLNQLESGKDAPVMERFDIVSLIRGVLGSMHIMIEQKEAAVIFEETEPV
                     YVWADEFKIEEVVTNYTSNALNHLDGERKVEIKVLQEEDCVKVTVFNTGTPIPEEDIPN
                     LWNKFYKVDKARTREYGGSGIGLSIVKAIIESMNQKYGVCNYDNGVEFWFTLDCRQ"
     CDS             complement(12159..12863)
                     /locus_tag="ctg57_11"
                     /transl_table=11
                     /translation="MKKNGGDQMDTLKILVVDDESRMRKLVKDFLTKKNFQVLEAGNGE
                     EAMDIFYEEKDIALIILDVMMPKMDGWEVCREIRKNSKVPIIMLTARSDERDELLGFDL
                     GVDEYISKPFSPKILVARVEAILRRTGQNNPEDVISAGGIVIDKAAHLATVDGKPMELS
                     FKEFELLTYFLENQGIALSREKILNSVWNYDYFGDARTIDTHVKKLRSKMGDKGEYIKT
                     VWGMGYKFEVDE"
ORIGIN
        1 attgttatta taataacgca ctttccgaca gatttcaacc tattaaagtg aaaaaatgca
       61 aaagtgccaa tcaaaaaagc agaaccacag tcatcactga ctatgtgttc tgctttttat
      121 catttcactt tcattattct gcagcgcttc cggctttctc aacttcagcg attgcctgtt
      181 ttctcattgg aatacggcag tttttgttgt taccgaattc tacgatcacg tcttcctctg
      241 tcatgtcaat gatcacgcca taaaagccgc tggtagtaac aatgctgtca ccaacttcca
      301 tgtcatttaa cattgcctga agtctcttct gctctttttt ctgagggcga agcattaaga
      361 agtacataat tccgaacagt actaccatcc agacaatagc gccaaccata cccattccgc
      421 ttgatgcgtc cattttgatt cctcctgtaa cttttcctgt tattctgcat atttgcagtc
      481 catcatgtat ttacagaccg tcctgacggc tgctcatact gaagagctgc tttgcgatcc
      541 acttataatc tccgttacct tctgtatgaa atcttgtttt catgcataac aatctgatta
      601 aagcgtcact atacatcata cacaaaaaaa cgctttactt caagagtttt tggcatattt
      661 aataattatt ttatatacag attatctttt cgagttaatt tttccctctt caaagccttc
      721 cagccgcatt ttcttatatt ctgcgaagtt tcctgcatca agagcatctc ggatctcttc
      781 catcatatga ttgtagaaat acagattgtg aagtacacag agacgcattc ccagcatttc
      841 ctttgctttc agaagatgac ggatataggc tctgctgtaa tgctggcatg caggacactg
      901 acagccttct tcgataggac gtgtgtccag ttcatatttt gcattgaaca gattcatctt
      961 tccatgattg gtatatacat gtccatggcg gccgttacgg cttggatata cgcagtcaaa
     1021 gaaatcaatt cctctctcaa caccttccag aatatttgcc ggtgttccca cacccatcag
     1081 gtaagtaggt ttattctgag gaagataggg gactaccgca tccaggatcc tgtacatctc
     1141 ttcatgggtt tctccaactg ccagaccgcc gacagcatag ccatccagat ccatttcaga
     1201 gatcgctttg gcatgctcaa tacggatatc ttcataaaca gcaccctggt tgattccaaa
     1261 cagaagctgt tctttgttaa tggtatccgg caaactgttc agtctcgcca tttccgcttt
     1321 acagcgggca agccatcttg tggtcctgtc tacagatttc tgcacataat ccctgtcagc
     1381 cacactgctg ggacattcat caaatgccat ggcaatggtg gaggcaagat tggactggat
     1441 ctgcatactc tcttccggtc ccataaagat cttatgtccg tcaatatggg agttaaaata
     1501 gactccctct tctttgatct ttctcagctt tgcaagagaa aatacctgga atccgcctga
     1561 gtctgtaagg attggtttgt cccataccat aaatttatga agaccaccta actgctttac
     1621 tattttatca cccggacgca catgaagatg ataagtattt gataattcta cctgtgttcc
     1681 gatctgctgt aaatccatgg tggatacagc gcctttaatc gcaccgatcg ttcccacatt
     1741 cataaaaaca ggagtctgga tcgtgccatg cactgtatga aattctgcac gcttggcacg
     1801 gccttctgtt ttaagaagtt tatattctgc cattttttct ctcctcttga taaaaatcac
     1861 tttttctatt atatcccgaa atagctgaat tttcaactgc aaataaggta atcattggta
     1921 aactttcata ttgtcttttc cagaccatta gcgtataata ttacggaata ttcatatctg
     1981 gaaatagata ttttaatagg aaagaattac ttcaatattt tttcttttat acagaaagag
     2041 gaggcttgaa tttactttat gaattacaaa acacttggaa ttgacattgg ttccactact
     2101 gtaaagattg cgatcttaga tgagaatgaa aatctcattt tcgcggatta caagcgtcat
     2161 tttgcgaaca ttcaggaaac ccttgcagac cttcttcagg aggcctttga ccagtatggc
     2221 gagatgactc tccatcctgt gatcacaggt tccggcggtc tgacccttgc caaccatctg
     2281 ggcgttcctt ttacccagga ggttattgca gtttctactt ctctgcagaa gctggcacca
     2341 aagacagatg ttgccatcga gcttggcggt gaggatgcca agattattta tttcgaaaac
     2401 ggaaacgtag aacagcgtat gaacggtatc tgtgcaggcg gtaccggttc tttcatcgac
     2461 cagatggctt ctcttctcca gacagatgcc acaggtctga atgaatatgc caaagattac
     2521 aaggcactct acccgattgc tgcacgctgc ggtgttttcg ccaaaacgga tatccagccg
     2581 ctgattaatg acggtgcaac caaaccggat ctgtcagctt ctattttcca ggcagttgta
     2641 aaccagacca tctccggtct tgcctgtgga aaacccatcc gtggacatgt tgcattcctg
     2701 ggtggtccgc ttcacttcct gtccgaactg agagaatcct ttatccgtac tttgaagctg
     2761 gatgaggaac acaccatcat tccggagaac tcccatcttt ttgcagccat cggttctgca
     2821 ttaaatgcaa aagaagacaa ctccatttcc ctgacagaaa tgaaagacag actccgcaat
     2881 tccattaagc tggattttga agtagaacgt atggaaccac ttttcgcttc tcaggaagaa
     2941 tacgatgcat ttgcaaaacg tcagagttcc tacaaagtaa aaacaggaga tctggctaca
     3001 tataaaggaa actgctatct gggtattgat gcaggttcca ccacaaccaa aactgcactg
     3061 gtaggcgaag atggaacact tctctattct ttttacagca gcaacaacgg aaacccgtta
     3121 aaaactacca ttcgttctat taaagagatt tacgaactgc ttcccgagga tgcaaagatt
     3181 gcttattcct gttctacagg ttatggcgag gctctgatta aggctgctct gatcctggat
     3241 gagggcgagg ttgaaaccgt atcccattac tatgcagcag cgttttttga cccggaggta
     3301 gactgtatcc tggatatcgg cggacaggat atgaaatgta tcaagatccg caacaagacc
     3361 gttgacagcg tacagttaaa tgaagcatgc tcctccggat gcggttcctt tattgaaacc
     3421 tttgccaaat ccctgaatta tacagtacag gatttcgcaa aagctgctgt ttttgcacag
     3481 catcctatag atcttggtac cagatgtact gttttcatga attccaaggt aaagcaggca
     3541 cagaaagagg gagctgaggt ttccgatatt tccgcaggtc ttgcttactc tgttatcaaa
     3601 aatgctctgt ataaggttat caaggtttct gacgcttccg aacttggcaa gcacatcgtt
     3661 gtacagggtg gtaccttcta caatgatgca gttcttcgaa gcttcgaaaa gattgcaggc
     3721 tgcgaagcca tccgtccgga tattgccgga atcatgggtg ctttcggtgc cgcactgatt
     3781 gcccgtgaac gccatcagga aggcgcagaa acgactatgc tctccattga taagattaac
     3841 gagctgaaat atacaacttc tatggcaaac tgtcgtggat gtaccaataa ctgccgtctg
     3901 actatcaaca aattctccgg aggccgccag tatgtaagcg gtaaccgctg tgaacgcggt
     3961 attggcaagg aaaagaacaa agatcatatt ccgaatcttt atgaatataa atataagcgt
     4021 attttctcct acacaccgct tactgctgat aaggcaacgc gaggtaaagt aggtatcccc
     4081 cgtgttctga acatgtttga gaattatcct ttctggtata ctttctttac agaactgaag
     4141 tatgaggttg tgctctctcc tacttccacc agaaagattt atgagctggg tattgagtcc
     4201 attccaagtg aatctgaatg ctatcctgcc aagcttgccc atggccatgt aacctggctg
     4261 atccgcaatg gcgtgaaatt tattttctac ccatgtatcc catatgaacg taacgagttc
     4321 ccggatgcag tcaatcacta taactgcccg atcgttacct cttatgccga aaatatcaaa
     4381 aataacgtag acgaattaaa tgatccgtcc attaccttcc gcaatccgtt ccttgcattt
     4441 acttctgagg aaattctggc aaatcgtctg gtagaggaat ttaaggatat cccggcagga
     4501 gaagtcaaag ctgctgtgca taagggctgg gaagaaatgg ctgctgcacg ccgcgatgta
     4561 cagaaaaaag gggaagaaac cctgaaatat ctggaagata caggacgcca tggtattgtc
     4621 cttgcaggac gcccatacca tattgacccg gaaatccatc atggtatccc ggatctgatc
     4681 aacagctatg gtattgccgt acttactgag gattccatct ctcatctggc acctgtggaa
     4741 cgcccgattc gcgtcaatga ccagtggatg taccactcca gactgtatgc tgctgcaaac
     4801 tatgtaaaga cacgcgatga cctggatctg atccagctca actcttttgg atgtggtctg
     4861 gatgcagtta ctactgacga ggtttatgaa atccttgacg gaagtgacaa aatctatacc
     4921 tgcttaaaga ttgacgaggt aaataacctt ggtgctgcaa gaatccgtat ccgttccctg
     4981 atcgcagcga tccgcgcgaa gaaagcacag ggacagaaac gtactgtcaa acctgcttct
     5041 attgataaag tatcctttac aaaggaaatg agaaaggact ataccatcct ctgcccgcag
     5101 atgtcaccgt tccatttcag cctcctgcag gcagcattca attcctgcgg atacaacctg
     5161 gaggtgcttc cgaatgacaa taagcatgca gtggatgttg gtctgaagta tgtaaacaat
     5221 gacgcctgct atccgtctct gatcgttgtg ggacagatca tggatgctct gctttccggt
     5281 aaatatgacc tgaacaaaac ggccgttgtc atgtcacaga caggtggcgg atgtcgtgct
     5341 tccaactata tcgcatttat acgacgcgca ttaaagaaag ccggtatgga acagattccg
     5401 gttatctctg ttaacttaag cggtctggaa agcaatcccg gattcaaact tacgcttcca
     5461 ttagtgaaga aagttgctta cggtgccgta ttcggagata tcctgatgaa atgcgtatat
     5521 cgtatgcgtc cttatgaact ggaagaggga atcgtaaaca ggaaacataa aatctgggaa
     5581 cagcgtgtga tctctttctt aagcggaagc agtatcagcc acagccagtt taaaaaaatg
     5641 tgccgcgaaa tggttcatga atttgatacc attcccatca gtgatgtgaa gaagccgcgt
     5701 gtcggcatcg taggtgagat ccttgtcaag ttcctgcctg ctgcaaataa tcatctggca
     5761 gagcttctgg aatctgaagg cgctgaggca gttgtaccgg atctgatcga tttcatgtgc
     5821 tactgcttct ataatcagaa ctttaaggta gaaaatcttg gattcaagaa gtccaaggca
     5881 accatggcaa actggggaat caaagcaatc gaatgggtga gaaagcctgc aagcgaagct
     5941 cttgcacaga gccgccattt tgcaccgcct gctgatatca gagatctggc aaaaatggca
     6001 tctccgatcg tttccaccgg aaaccagaca ggtgagggat ggttcctgac aggtgagatg
     6061 atggaactga tccatggaga tgttccgaat attgtttgta tccagccttt cggatgtctg
     6121 ccgaaccaca ttgtaggtaa gggtgttatc aaagaaatcc gcagagaata tccgacagcc
     6181 aatattgtag ccatcgacta tgacccgggt gcaagtgaag ttaaccagct gaaccgaatc
     6241 aaactgatgc tctccacagc ccagaaaaac ctgaaaaaag cagaagaaaa aaatgcataa
     6301 ataataccgt aatggatata ttgcaatgta ttttaccttg caatatatcc gccttagagc
     6361 gtgtctgaaa aatgctttac gcaagatgtg cgtcacaatt tgtgggagat tttgttcgga
     6421 tgagggcgtc gtagcgggct acgacaaccg aattcggaca aaatataccg caaagcattt
     6481 ttcaaacgcg ctcaaaaaaa gagttatatt tcagaaattt taaatgtgtt tctatttcag
     6541 aactacattt aaaccatgaa atataactct tttgttttta taatttcagt gtttaattat
     6601 tctgccagaa cggaagtttc tctgcaatcc ttatcagata gcttccaccc ggaattcttc
     6661 taagctgtga ttctgacggc ttgctgataa tcaggtaagc aaacagataa acaaccgcag
     6721 caacaggaat ggaaacgatc agacaaatga aattggattt tacaaaaatg ttcagtccat
     6781 agcagataca gcctgcaaca attcccatgg gaacagatgc aagaacagga tacagatatc
     6841 cttctttcca tggattctta tactgcagat atttcttcat ggctctgtca tttaacacac
     6901 atacaaccac agaatagatc accattgcga tcagcagtgc ataaactcca aggtttgtag
     6961 taaacagtag cactaccact accacaatgt ccacaaccag tgcgattgca gccgtaatca
     7021 ccggaatcct ctgctgtccg attgcctgca gaactccatt ggaaatattt gacattccat
     7081 tgagcaggat cgaaaaagaa ccaaggatca gcaggttggc tgccagtcct gtggaatttc
     7141 cgtaaagcaa aaatacaatc ggctgtgcaa gcactgccag tcccattgca catggggcgg
     7201 aaactaccat agaaagctgt acggtctggt caatgcactc tctggtcgct tcaatatctc
     7261 cggtggcata tagagcggaa acttccggaa tcatggaagt aggtgccgta ctggacagcg
     7321 tcagaggaat attgataatt gtcataaagt aagtagcata ctctgcatat aaaataccaa
     7381 tctgtgccgc atctccacct cttcttccca gaatatccga gaaaagatac ccattgatat
     7441 aagcatttac attataaaca aaggcgctga gaatgatcgg cgaaacaacc aggatgatca
     7501 cacgaaaaat ctctttgtag gactcttcct gatgtctgtg atctctctct acccggtgca
     7561 ggatttttct gcggtttaca ccatatacca gaagcatgaa tgccaatgca gtcaccactc
     7621 cggctccggt tcctactgtg gaacctgctg ccccccattt tgcaatgctg ttctctgttc
     7681 catctgagaa tgcattgatg aatccccagg ctgccagaag actgactgct gcattaaata
     7741 cctgctcaat gatctgggag atagatgttg gcatcatatt tctgtatgcc tgaaaatatc
     7801 ctctgaatac cccaagaata ccggacaaaa aaatcgtcgg agccagaatc tgaagtgccg
     7861 gaattgcatc cttctgattc tgagggatga tcagtcctgc tccaaagaga cagaataaac
     7921 cgaccactcc gccaatcacc atggcataga tcatggcacc cttaaagaac ttatgtgcat
     7981 ttctgtaatc cttcagggca atacgctcgg agatcagttt ggataccgcc tgtgggatac
     8041 taaaggatgc gatcatcaga aggatcatat aggcattctg cgcaagactt gtatagccca
     8101 ttccaaggct tcctataata ttggaaaggg gactcttgta cagaagaccg atcaccttgg
     8161 agatcatagc tgcaatcatc agaaaggatg cattttttac taaattgttt ttctgattca
     8221 tgttatcact gtgtgtcttt tacctgacta cacattacct cttttcttat atattttcta
     8281 tctgccagtc gattggttcc agaccattgg caacaagaaa ttcgtttgtt ttactgaaat
     8341 gtttacatcc gaaaaatccc ctgtaagcag acagaggact tggatgaggt gcctccagaa
     8401 tcagatgctt cggattattc agcatggatt ttttcatctg cgccggacgt ccccatagca
     8461 gaaatacaat aggacggtcc tgctcattca gaacctggat cgcagcatcc gtaaactgct
     8521 cccagccgat ccccctgtgt gaatttgcct gatgggcgcg tacagtcaga actgtgttca
     8581 gaagaagcac tccctgcttc gcccacttct ccagatagcc gttattgggg atatagcatc
     8641 cacagtcatc atgaagctcc tgataaatat tcaccaggga cggcggagtc tccactcctc
     8701 tctttacgga aaaacaaagc ccatgagcct gcccgtcatt atgataggga tcctgtccca
     8761 ggattactac cttcacttcg tttaacggtg taaaatgaaa tgcattaaac agatcatccg
     8821 caggaggaaa aatcttcctg gtctgatatt ctgtcatcac cgttttatat aatttcgcat
     8881 aatacggctg gtgaaactcc cccttcaggg cttccagcca gtcacctgaa attgctgaca
     8941 taccttatcc ttcacctctt atatttttcg tggtcatcgt ctgacagaaa ttcccctgtc
     9001 agacagataa tccttcacct gagaaatctc cagttcttta taatggaaca aagacgcagc
     9061 cagtgcagca tctgctcccc cttcggtcag tgcatcataa aaatgctcca gtgtacctgc
     9121 accgcctgat gcgatcacag gaatggagac agcatcagca attgctctgg taagagccag
     9181 atcatatcct gcttttgtac cgtcacagtc catactggta agaaggattt cccctgcgcc
     9241 caaagcttcc actttctttg cccactctat ggcatcaatc cctgtatcca gtcttccgcc
     9301 atgtttgtaa atattccatc cgccgtcttc tctgcgcttg gcatcaatag ccacaactac
     9361 gcactggctt ccaaacttgt cagccgcctc actgatcagt tccggtctgt caattgctgc
     9421 agaatttacg gaaatcttat ctgctccttc tctcagcagt ttcttgaaat catctacagt
     9481 acggataccg ccacctactg taaacgggat aaatacattg gcagcaaccc gtcttaccat
     9541 gtcaactacc gtatctctct gttcgcagga tgctgtaata tcgagaaaca ccagttcatc
     9601 tgctcctgct gcatcatagg ctttggcaat ctccaccgga tcacccgcat cgcgaagctg
     9661 cacaaaattt acgcccttta ccacacgtcc gttatttaca tccaggcagg gaataattct
     9721 ctttgtaaac atcttatttt ccctccttct cagtattgcc gtcttttccc acagcagcaa
     9781 aattttcaag tatcttcagt ccccatttgc tgctcttttc cggatggaac tggcaggcaa
     9841 atacattgtc cttttctacg gaagcatgaa tacaggtgct gtattctgta gtagccttta
     9901 caatctcagg ctcctctgcc tgcagataat aagaatgcac aaaatataca taggtctgtt
     9961 ccgggattcc ttgaaacagt ctgccattat tctgaaaatg cagggaattc catcccatat
    10021 gtggaatctt aagcccgggc gcaggcggaa tcttaacaat tttccctttc aggattccaa
    10081 ggccttccac ccccggtgtc tcctcgctgc tttcaaaaag gagctgaagt cccaggcaga
    10141 ttccaagaaa tggcgtcttc ttctctacaa tctcatggat cacaggtaca agtccgtatg
    10201 tatgaagatt ctccatcgcc tgtccaaagc ttcccacgcc cggcaggatt actttatccg
    10261 catttaacaa agtctgcgga tcgcgggtta ctgttgtttc ttccccaaga taatgaagtg
    10321 ctttttctac acttttaata tttccggcat catagtcaat tattgcaatc atgttatcct
    10381 cctgatgtca ttatccgttt tcctcattat ggtaatccga aggttttccg gatcacatgt
    10441 cagaccggaa taaaatatcc gatcaaaacg ctccaataca gtataaccca aaaacagaca
    10501 gttgcaaagt gctttctttg cttctgtctg tttttattcc ggtcatacta ccggttactg
    10561 ttcactccat tcacagtaac acgcttctca ctacgttcac aatacccgga tatcttatca
    10621 ctgcctgcaa tccagagtga accagaactc cacgccatta tcataattgc ataccccata
    10681 tttctggttc atactctcaa tgattgcctt aacaattgaa agtccgatac cacttccgcc
    10741 atattctctt gtccgggcct tatctacttt atagaattta ttccagagat ttgggatatc
    10801 ctcttccgga atcggagtac ctgtgttaaa tacggttact ttcacacagt cctcttcctg
    10861 aagaacctta atttctactt ttcgttctcc gtccagatgg ttcagtgcat tgcttgtata
    10921 attggtcaca acctcttcaa tcttaaactc atccgcccat acatatacag gttctgtttc
    10981 ttcaaaaatc acagctgctt ctttctgttc gatcataata tgcatagaac caagtacacc
    11041 cctgatcaga gatacaatat caaatctttc catcaccggg gcatctttac cggactccag
    11101 ctgattcagc gtcagcaggt ttttgaccag cttgttcatc tttgaagcct catccataat
    11161 aacttcacag taaaattccc tgctttccgg atcatcggaa atattttcat tcagcccctc
    11221 tgcatatccc tggatcaatg caataggagt tttcagctca tgagaaacat tatcaagaaa
    11281 ttccttacgc atctcatcaa ttttaatctt atcttctatg tctttctgaa gcttgttatt
    11341 agccgatttc aactctgaga tcgtgctctc aagttttctg gacattttgt taaagttatc
    11401 gccaagtaca tcaatctcat tacctgccct gctttgatat ctggcatcaa aatccagatc
    11461 agacatcttc tctgataatt tggtcagttc actgatcggg cgggtaatac gatttgtcat
    11521 cacaagaatc acaataccgc tgatcacaat tatgattatt cctacaatga agtaaaaact
    11581 gttggaaata gatgcacttt ccttaatact ttccagagga gaacggatca ggaaatagta
    11641 accattatca aactgtcccc agcattccac atattccatg cctgcaaagc gatcatgcac
    11701 ctgccacatg gtacaggtat ctgtcttttt gagcacacga ctgtgctgca tatcctgatc
    11761 cagattatta atatacccaa acagcttact gcggagcatt tttgccatat tattctctcc
    11821 ccagtaataa taaccgctgt tttcctcatt tactatgatc caggtaaggt tatttctgga
    11881 actgctcctc tcaatctcat ccgaaatctc atctgttgcc ccttttttgt cctcttctat
    11941 atctgtatca tactgcagga tgtcatccag attcatctga gacaacactt cttttgcctc
    12001 ctccagcact tctacttttt tggatacata atatttttca agaaaaagac cattgatcag
    12061 agtaatggta aagatcgaaa gcagtaacag acatataaac actactgaaa tctgatgttg
    12121 cagagtatga aattttttat ctgtttttcc ggttcctgtc attcgtctac ctcaaacttg
    12181 tatcccatac cccatacagt ctttatatat tcacctttat ctcccatttt acttctgagc
    12241 ttcttaacat gggtatcaat cgtacgggca tctccaaagt agtcataatt ccatacagaa
    12301 ttcagaatct tttctctgga aagtgcgatt ccctgattct ccagaaaata tgtcagaagt
    12361 tcaaattcct taaagctcag ttccataggc ttaccatcca cagtagccag atgtgctgct
    12421 ttatctataa caatgccgcc tgctgaaatc acatcttccg gattattctg acctgtacgt
    12481 ctcagaattg cctccactct tgcaacaagg attttcggac tgaatggttt ggagatgtat
    12541 tcatctaccc ccagatcaaa tccaagaagc tcatctctct catcacttct tgcagtcagc
    12601 ataatgatcg gaacttttga gttcttgcga atctcacggc aaacttccca tccatccatc
    12661 ttcggcatca tgacatccag aatgatcagt gcgatgtcct tctcctcata aaagatatcc
    12721 atggcttctt caccattacc ggcttccagt acctggaaat tcttctttgt caggaaatcc
    12781 tttaccagct ttctcatgcg gctctcatca tccaccacca ggatttttaa tgtatccatt
    12841 tgatcccctc cgtttttctt cattattttc cgaaacagtt tttacttttt atttatactg
    12901 ttttccgagt attgttaaaa tccacgactg ttcagcgcct ttacagccac agcgcaaaat
    12961 ccgggaaaat cgccctcagc aacagatttt atctttcata tggttactat agcagagatt
    13021 tatgtaagat ttgtgaacat atgacagaaa aattataagt attgctgttc acaacaccaa
    13081 atagccttaa atataaaaat cttcttgaca aattctgttt ttatttctat actgttaatc
    13141 agtcgatata tcttatataa tgaatgatat atcaatatta aaaagtgctt tcgtctcatc
    13201 accagtgctg ttttatgaaa aaacagcgtt gcagactcat tttcagggct tgtactggtt
    13261 tcgacggggg ctttgaagtt ggggaagcca tccgcagact cccagactgc gtaccaaccg
    13321 ggaaactaaa tataaacgca gacgaacagt acgcgttagc agcctaattg ctgctcgtca
    13381 gccctgatgc actcacactt caggaatctg acgtcgacca tgtgagaaac cttgccgggt
    13441 aagctttgcc ccggtagatg tatcatgaag ctactaaggt tgtaagcctg tcggtgggcg
    13501 tacatccaag ggaatgttaa aacagcgact gtgatgggag atgccttaat gaataggctt
    13561 tcggacgcgg gttcaattcc cgccaggtcc acttgaccac gacaaagcga accctgacaa
    13621 ttttgtacag taattgtata taagaatgtc ggaatgttag ttgtgtcgtt ggaacggtaa
    13681 acaaaaaaga gggtttttag ccctcttttt ttgtgtctgt ttctcttaat tgtaatgaga
    13741 cagcactatt taagtatcca cagtctcaaa aaaatcctca aaaaacttct ttttttcaaa
    13801 gcagggctgg cacagtttgt atgggtagcc aaatggcagg ttccttccgc agaccataca
    13861 cctccgtctt ttcaatttct tttccctgat cgtatctgtc agctcttttg agatttcctt
    13921 ttttctctta cgtatcagat tcttatccca gttttgtctc cccggcattc caaaaagacg
    13981 gacgaaactg tggaacatgt catatttctg atgcagaact tccagtgcct ggattttttt
    14041 gttgatgcgg tcgtgcttga atgaaaaagt aaattctaca ttctaatata ccttgatttt
    14101 atgcgggat
//
