LOCUS       gnlProkkaOMKAEKNI_4    13120 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|OMKAEKNI_4.
ACCESSION   gnlProkkaOMKAEKNI_4
VERSION     gnlProkkaOMKAEKNI_4
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-18 00:25:10
            Original ID  :: gnl|Prokka|OMKAEKNI_4
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13120
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13120
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[2868:3120]"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      2869..3120
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..13120
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..13120
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             3..686
                     /locus_tag="ctg4_1"
                     /transl_table=11
                     /translation="MNPIGFPGLKMAITSDESKMINFNDNPKVIISASGMCEAGRIRHH
                     LKHNLWRKDSTILFVGYQVPGTLGFSLLNGAKEVRLFGETIEVAARIENLPGISGHADV
                     EQLTKWAAAFENKPKKVFVVHGEDKVTEQFADHLKDTLGYEAYAPFPGDAFDLATGEQV
                     REGSRERAEKKITEKSRASSNVFARLLAAGQRLLTVINKCEGMPNKELGKFADQINALC
                     NKWDR"
     CDS             complement(683..1462)
                     /locus_tag="ctg4_2"
                     /transl_table=11
                     /translation="MASYKVEICGVNTAKLPILKEEEKDALFARIKQGDTAARETYIKG
                     NLRLVLSVIKRFSGNHENVDDLFQIGCIGLIKSIDNFDPTIGVKFSTYAVPMIIGEIRR
                     YLRDNNSIRVSRSLRDTAYKAIHTKEILSKTENKEPTLDEIAAESGISKEDIVFALDAI
                     QSPLSLYDPVYTDGGDTLYVMDQISDKKNREENWIEELSLNDALDRLNERENYILKLRF
                     FEGKTQMEVADEIHISQAQVSRLEKSALKSIRHYLSL"
     CDS             1604..1927
                     /locus_tag="ctg4_3"
                     /transl_table=11
                     /translation="MMMKDMIDKRNERERIARSIIKYWNVNYIPRTQADSGMQKQTAEA
                     ENAQDQTMDPNMQEDYNKATNAYSGKYGQEKDLDEVTKDQIDKILHEKAEHIHQLFENG
                     GVE"
     CDS             1983..2828
                     /locus_tag="ctg4_4"
                     /transl_table=11
                     /translation="MSEIILRKYHGVGNDYLIFDPKKNDVVLNERLIRQLCRRNIGVGA
                     DGILYGPVMEDKKIKVRIFNPDGSEAEKSGNGIRIFSRYLKDAGYVKERQYYLTTKAGE
                     TLVTFLDDAGSCMRVDMGYAVFEAEQIPALGFEGEVVGESIFFCDNFYNATCVSMGNPN
                     CVIMLERVDREKALHLGPYVENAKYFPNRINMQLCQIVDEKNIQVEIYERGAGYTFASG
                     TGACAAAAASHRLGLVEDAVTVHMHGGDLFIEFEKDGRIFMTGPVVYIGKITVAEQFFA
                     "
     CDS             2869..3120
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg4_5"
                     /sec_met_domain="PF05402 (E-value: 7.6e-15, bitscore: 46.9,
                     seeds: 461, tool: rule-based-clusters)"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 9.1e-11,
                     bitscore: 33.6, seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKEWYQLRQAAGAYWLLDMEQGEQYKKPFMLNECGAYIYRAYISG
                     MSEDEITQAFAKEYGLSFSCAQSDVGQFMMELRQQGII"
     CDS             3134..5311
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010:NAD-dependent epimerase/dehydratase (Score: 80.1;
                     E-value: 3.1e-24)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg4_6"
                     /sec_met_domain="RmlD_sub_bind (E-value: 9.3e-20, bitscore:
                     62.6, seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNILLVGNAGNFMRLMINRLNKEGHRVFVLTEEPKKGYSLKKVFE
                     VYHFSYEDACVREVLESIMPQVVVFLGAYDHNFSWNRVENTAASYAAGLTNILMNYTAL
                     KKGRFVYLSSESVFGGGSAQFMTEDDPTGAYSKKGQAIAIGEDICKNYARMGNDVVILR
                     LDHLYGEIRKKEDTDTICADMCLEAVQTGEIIASQNEKIMLLHEADAVEFIYQIMVAKD
                     HKHTLYQLSSGEKMSRYELAQAVAAGMENEVSIVEEENKKYREVMLSGKRYDEEFGSRV
                     LHHAETDVEKIAAYFSRHVSEFTDAGQKKGHLFRRLGSRTKEIITNLIPFMENLICFIP
                     FFMLNNRAVGSEYFQNIDFYLLYVLLFALVYGQQQATFSALLAVAGYCFRQMYHRSGFD
                     VMLDYNTYVWIAQLLILGLAVGYLRDQLRAMREEQRHEVSYLTKQLDDISDINVSNVRV
                     KEILANQIVNQNDSFGKLYEITSSLEQYEPCEVLFYAAEVLAKLMGSKDVAIYTVANRS
                     YARLFSATSEKARSLGNSINYSEMDAMYTVLAGKKVYINKNMDERYPLMANAIYSEDEM
                     QLILMIWGIPWERMTLGQANMLTVIGYLIQNAVVRANRYISALEQQRYIKGTNILEPEA
                     FLALVKAYLNARDKGLTQCALLSVDTKENDRDEVGKRLIKLLRQSDYVGELEGGKMYAL
                     LANTSAKDATMVKERFEKEGVSCQIQEDVFV"
     CDS             5308..6219
                     /locus_tag="ctg4_7"
                     /transl_table=11
                     /translation="MTVVEKRFCIVLLINTAVAVLYVIGNSRIRQKEKNTDILMKGIMM
                     FLCPVVGPLFFLAGLVFNKVFFRQNVDLEDVIFSKERVKTHLRADEEREGNLVPIEEAL
                     AISDKDSLRTLVMNVVRGDVQNSLASISLALNSEDTETSHYAATVLRDALNDFRKRAQE
                     LYLQMKQEGVDAAEAACILIEYMHGVLIQEVFHEKEQQTYIDMMEEACNFLDEKYQEKL
                     QASYIEGLCVLLLKIKDFKRMKYWCDKSRELYPAELSTYTCYLKLYFTEGNKKHFFDEL
                     EKLKNSDIVIDRETLELIRIFS"
     CDS             6234..8636
                     /locus_tag="ctg4_8"
                     /transl_table=11
                     /translation="MSMKVLTVLQFISIFTIYTGLFIAVPALLLHRRLKDEIFSVRFFF
                     YIVLGHFYLINLVLFLQLLHISGRFTLILGSALPVVISLVHTKRVSPKKIGHIIGNRTS
                     HVIRETLGIKLLLLEIVQWIGRKIKKLCGRMCGLIIRHFADGVLFVVFTATVLVMYGTN
                     MINTYGYCASDIPVHNYWINAMGQNDVFVAGIYPFGFHCVIYYIHTVTGIETYVLLRLF
                     YVVQVLYIHYALLAFLKACCRTSYCAWGAVFVYVLAAFFNRNTYSRYYSSLPQEFGMIF
                     ILPGIYFMYAFLKQRKIEVNQCNKERNAAGLKTWKCKSTRYLMGFIAGFGLTLIVHFYD
                     TMVAGLFCIGIAGGYLLRIFKKEYFFRVLATGLLSIFLAVLPMGIAFLQGTPLQGSLGW
                     GLNVINGSNNTGAEEEDEADIPGSEKEEINTNTQSVTDQSMTESTDTAGSITDQTMSEN
                     GVENAQMTEGTQVKTTRFGMLVEKIRFRITDITQNGLDYLWTGVHNVVMLQASVPWMLF
                     IFGCEGFCLIGGLLFTLIGKHDYGSMLMSAGFGLLLLMMFLSAWRFGLPHIMDASRCSI
                     YVAYMIPVAIGLGMDGMVTLVFGFFKRNIWMNLVSLMTSAALVATLVNGNQIRTPSILT
                     ALQSNAAITCLANIKRENEKYKYTICSANDELRMMEDYARHEETITFLRSMEGDAVNGN
                     LTLPTDRVYFFIEKIPLDYTVAYEGSGQLISEEGAKKPLPTAGDISVYEGENRWIVMSR
                     MYYWAQAFMELYGKEMQVYYETDDFICYVVEQNTYSLYDFSIDYGYN"
     CDS             8687..10504
                     /locus_tag="ctg4_9"
                     /transl_table=11
                     /translation="MVSRRNFAAITIMLMILLFMFQFTGVMKDKLSKYGINEYKESATT
                     ELTKQDMYLASGQNIQKTAGVLYIGNSEAVKNTVKWWCTYSKREFQTADSFDGIVSEDS
                     RLPDILVLDGTCLNTRDNIKAVSDAAEKGVNVIVSGLPDAEEIEKNDRLRKLLGIRYVE
                     QNEVTLDGIHLFEGFLLGGEVIYQAKDEEEEKNQDMDLKIPWYVTGEGTKSYMVGILSD
                     VRPDSGRQPAIIWRNGLENACVFCINGNYLKDNSGIGILDAMMAESYSFEIYPVINAQN
                     LVIANYPGFASENEDKMEKIYSQSQKALFREIIWPSLVAIERKIDAKLTCMMTPQFDYG
                     DENEPREGEVAYYLKLLKEEYGEAGLSSGNVSGTGLSEKMEKDETFWKKEAPDYCFQSL
                     YLQNEDELGDALECEELDGIRTIVTRESQTSDEPIVSFAGEEVTLQRATGDGVNHTFMD
                     DFRQRCIQTALGYSNTVWDLLAAAYPEKKDDAWEILSKEAASNICTYQKPFTAFDETTI
                     SKSDQRIRRFLALSYSAESEDNMISLHVDGLEEEAWFLLHTGTREAEDIQGGSFSVVED
                     GVYLICAEEDEVKIRLSEEEEKQLFYYED"
     CDS             10507..11949
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1045:glycosyl transferase group 1 (Score: 118.1;
                     E-value: 8.6e-36)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg4_10"
                     /sec_met_domain="Glycos_transf_1 (E-value: 1.4e-25,
                     bitscore: 81.7, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKVCIVAEGCYPYVVGGVSSWINSMIKAFPDIEFVVLAIVANRSY
                     RGKFVYELPENVSEVYELYLEDYDWVEQEKNKKLHLRQNEYEALRSLLLNRNVEWDTLF
                     TLFEKKNFSLNALLMGEDFLNAVRECYQLRYPQVVFSDFLWTMRSIYLPLFLTLKMELP
                     EADLYHCVATGYAGVIGSMAKKRYGCGLMVSEHGIYTREREEELIRAKWVGGIYKNIWI
                     EQFKKMSLLAYRYADQVTCLYKHAMELQIELGCPAEKIKITPNGIDDQRFVRCLEEERR
                     EDDTINIGAVLRIAPIKDVKTMIRAFAYAKKEAPKLALWIMGPSDEEKEYAKECFELVD
                     LLGVEDVIFTGKVDVTEYLGKMDMTILTSISEGQPLTILESFAAKKPVIATDVGNCRGL
                     IYGEGDSFGDAGIITHIMNVEEIAAAMVDLACHREKRIGMGKNGYRRLKSRYLVEDMKE
                     TYRQIYRQFEDEGRVQGKKGDV"
ORIGIN
        1 ggattaatcc gatcggattt ccgggactta aaatggcgat cacaagtgat gagtcaaaaa
       61 tgatcaactt taatgataat cccaaagtta ttatctctgc atccggaatg tgtgaggcgg
      121 gacgtatccg ccaccatttg aaacataatc tgtggagaaa agattccacg atcttatttg
      181 tgggatatca ggtgccggga acacttggct tttcactctt aaatggtgca aaagaggtaa
      241 ggctctttgg tgagacaatc gaggttgcgg caagaatcga gaacctgccg ggtatcagcg
      301 gccacgcaga tgtggaacaa ctgacaaaat gggcggcagc atttgaaaat aagccgaaaa
      361 aagtatttgt ggtacacggg gaagacaaag ttacggagca gttcgcggat catttgaaag
      421 atactttggg gtatgaggcc tatgcgccgt tcccgggaga tgcatttgac cttgcaaccg
      481 gcgagcaggt acgcgaagga tccagagaac gggcagagaa gaagataaca gagaagagcc
      541 gtgcatcgag caatgtattt gcaagactgc ttgctgcagg ccagagactt cttacggtta
      601 tcaataagtg tgagggaatg ccaaacaaag aacttggcaa atttgcagat cagatcaatg
      661 ctctgtgcaa taaatgggat cgttagagcg acagataatg acgaatggat tttaacgcag
      721 atttttctaa gcggctgacc tgagcctggg agatatggat ctcgtcagcc acttccatct
      781 gcgtttttcc ttcaaaaaag cgaagtttta agatataatt ttcacgttcg tttaaccggt
      841 cgagagcatc gtttagggac agctcttcaa tccagttttc ttcccggttt ttcttgtcac
      901 tgatctggtc catgacatag agtgtgtcac cgccatcggt gtagaccggg tcataaagac
      961 tgagaggact ctggatggca tcgagggcga aaacgatgtc ctctttagaa atgccggatt
     1021 cggcggcaat ttcgtcgaga gtcggctctt tgttttccgt ctttgagagt atttctttgg
     1081 tgtggattgc cttgtaggca gtgtcgcgca gggaacggct gacgcggata gagttattgt
     1141 cgcgcaggta acgtcttatc tcacctataa tcatgggaac tgcgtaagtg gaaaacttaa
     1201 ccccgatcgt cggatcgaag ttgtcgatgg acttgatcag accgatacag ccgatctgaa
     1261 acagatcatc tacattttcg tgattgccgg aaaaacgttt gatgacactt aataccagcc
     1321 tgagattgcc tttgatataa gtttctctgg cggcggtatc tccctgtttg atccgtgcaa
     1381 acagagcatc tttttcctct tctttcaaaa tggggagttt tgcggtgttg acgccgcaga
     1441 tttctacttt ataagaagcc atgctgttta tcctccggaa ttttatcttt accataaaga
     1501 gcatgcttca aaaggatgaa ttttattcag aaattaactt tttttccaat gggtttcgtg
     1561 ctaaaataaa aaggtatcaa aaatcagaac agagtgtggt gcagtgatga tgaaagacat
     1621 gatcgataag agaaatgaac gggaacgtat cgcaagaagt attatcaagt actggaatgt
     1681 gaactatatt ccgagaacgc aggctgattc cgggatgcag aagcagactg cggaggcaga
     1741 aaatgcgcaa gaccagacta tggatccaaa tatgcaggaa gactacaata aggcaacgaa
     1801 cgcatattcg ggtaaatatg gtcaggagaa agacttagac gaagtgacga aagatcagat
     1861 tgataagatc ctccatgaga aggcggaaca tattcaccag ttgtttgaaa atgggggagt
     1921 agagtaacca tttcctgtta ttctgcatat gatatcacaa ggaaaatggc agaggaatca
     1981 agatgtctga gatcatactt cgcaaatacc atggagttgg caatgattat ctgatctttg
     2041 atccgaagaa aaatgatgta gttttaaatg agagattgat aaggcagctt tgtagacgca
     2101 atattggtgt cggtgcagat ggaattttgt acggaccggt tatggaagat aaaaaaatta
     2161 aagtacgaat ttttaatccg gatggaagtg aagctgaaaa aagcggcaat ggcatccgga
     2221 ttttttcaag atatttaaaa gatgccggat atgtaaaaga aaggcaatat tatctgacca
     2281 cgaaagcggg ggaaacactg gtaacatttt tggatgatgc tggaagctgt atgcgtgtgg
     2341 atatgggata tgcggtcttt gaggcagaac agatcccggc acttggattt gagggagaag
     2401 ttgtgggaga atcgatattt ttctgcgaca atttttataa tgcgacctgt gtatccatgg
     2461 gaaatccaaa ttgtgttatt atgcttgaga gggtagatcg tgagaaagca ctgcatttag
     2521 gaccatatgt ggaaaatgca aaatattttc caaaccgtat caatatgcag ctttgtcaga
     2581 tcgtagatga aaaaaatata caggttgaaa tttatgaacg tggggcgggg tatacatttg
     2641 cttccggcac cggagcctgt gcggcagcag cggcttctca ccgtctggga ttagtcgaag
     2701 atgcagtgac cgtacatatg cacggtggag atctttttat cgaatttgaa aaggatggaa
     2761 gaattttcat gacaggaccg gtcgtatata taggaaagat tactgtggca gaacagtttt
     2821 ttgcctgaca gaaaacgaaa gtggcgaaaa gaggggaaat aagttacaat gaaagaatgg
     2881 tatcaattac gccaggcagc gggggcatac tggcttttgg atatggagca gggggaacaa
     2941 tataaaaagc cattcatgtt gaacgagtgc ggtgcatata tatatcgtgc gtatatttca
     3001 ggaatgtctg aggatgagat cacgcaggca tttgcaaaag aatatggatt gtcattctcc
     3061 tgcgcacaaa gcgacgtagg gcagtttatg atggagttaa gacaacaggg aattatttga
     3121 gaatggagca ggtatgaata tattgctagt tgggaatgcc ggcaatttta tgcggcttat
     3181 gatcaacaga ctgaataagg aaggacacag ggtctttgtg ctgacagaag aaccaaagaa
     3241 gggatacagc ctgaagaaag tatttgaagt gtatcatttt tcgtatgagg atgcctgtgt
     3301 gcgggaggta ttagagagta ttatgccaca ggtagtagtt tttctggggg catatgacca
     3361 taatttttcc tggaacaggg tggaaaacac agcggcgtcc tatgcagcgg gacttacgaa
     3421 tatactgatg aattataccg ctttaaagaa aggcaggttt gtctatcttt cttcggagag
     3481 tgtttttggc ggtggaagcg cacagtttat gacagaggat gatcctaccg gggcatacag
     3541 caagaaaggc caggcgatcg ctatcggaga agatatctgt aaaaattatg caaggatggg
     3601 gaatgatgtt gtgattctcc gcctcgatca tttgtatggg gaaatacgaa agaaagagga
     3661 tacagatacg atctgtgcgg atatgtgcct cgaagcagtc cagaccggag agatcattgc
     3721 gtcgcagaat gaaaaaataa tgcttctgca tgaggcggat gcggtggagt ttatctacca
     3781 gataatggtg gcaaaggacc ataaacatac cctctatcag ttatcttccg gggagaaaat
     3841 gtcacggtat gagcttgccc aggctgttgc cgcaggaatg gagaatgagg tcagtatcgt
     3901 agaagaggaa aacaaaaaat accgggaagt tatgctttcc ggtaaaagat acgatgaaga
     3961 atttggaagc cgtgtgcttc atcatgcaga aacagatgtg gaaaagattg cggcttattt
     4021 cagcagacat gtatctgaat ttacagatgc agggcagaaa aagggacatc tgtttcgaag
     4081 attaggcagc aggacaaagg aaatcataac gaatctgatt ccttttatgg aaaacctgat
     4141 ttgttttatt ccgtttttca tgttgaataa ccgtgcagtc ggaagtgaat actttcagaa
     4201 tattgatttt tatcttctgt atgtgctgtt gtttgcactt gtatacgggc agcagcaggc
     4261 aacattttct gcattgcttg ccgtggcagg gtactgtttc cggcagatgt accacagaag
     4321 cggatttgat gttatgcttg actataatac ctatgtctgg atcgcacagc ttttgatctt
     4381 aggtctggca gtgggatatc tgagagacca gcttcgtgca atgagggagg aacagcggca
     4441 tgaagtatca tacttaacca agcagttaga tgatatttcg gatatcaatg tcagcaatgt
     4501 cagggtaaaa gaaattctcg caaaccagat cgtaaaccag aatgacagtt ttggaaaatt
     4561 atatgagatc acatccagtt tagagcagta tgaaccctgt gaggtacttt tttatgcggc
     4621 ggaagtactt gcaaaactga tgggaagcaa agatgtggca atctatacgg tggcaaaccg
     4681 ttcctatgca cgtctttttt ctgcaacatc ggagaaagca cgcagcctcg gtaattcaat
     4741 caattacagc gagatggatg ccatgtatac ggtgcttgcc gggaagaaag tttatattaa
     4801 taaaaatatg gatgaaagat atccgcttat ggcaaatgcc atttattcgg aagatgagat
     4861 gcagctgatt ctgatgatct ggggaattcc gtgggagcgg atgacgttag gacaggcgaa
     4921 tatgctgacg gttatcggtt atctgattca gaatgcggtg gtgcgtgcaa accgttatat
     4981 ttctgcctta gagcagcagc gttacataaa aggaacgaat atattagaac cggaagcctt
     5041 tttagcactt gtaaaggcgt atttaaatgc gcgtgataaa ggattgacac agtgtgcact
     5101 gctttccgtg gatacaaagg aaaatgaccg tgatgaggtc gggaaaaggc ttatcaaact
     5161 ccttagacaa agcgattatg tcggtgaact tgaaggtgga aaaatgtatg cgcttcttgc
     5221 aaataccagt gcaaaagatg caaccatggt aaaagaaaga tttgaaaaag agggtgtgtc
     5281 ctgccagata caggaggatg tatttgtatg acggttgtgg aaaagagatt ttgtatcgtt
     5341 cttctgatca atacggctgt tgctgtttta tatgtgatag gaaacagcag gatcaggcag
     5401 aaagaaaaaa atacagatat tctgatgaag gggatcatga tgtttctctg cccggtagtg
     5461 ggaccgttgt tttttttggc gggactggtg tttaacaagg tttttttccg gcagaacgtg
     5521 gatcttgagg atgttatttt cagcaaggag cgtgtaaaga cacatcttcg ggcagatgag
     5581 gaaagggaag gaaatttagt accgattgag gaggcacttg cgatcagcga caaagacagt
     5641 ttaagaacgc tggtcatgaa tgtggtccgt ggggatgtac agaattctct ggcatccatc
     5701 tcgcttgcgt taaacagtga ggacacggaa acatcacatt atgccgctac agtattaagg
     5761 gatgcattga atgatttcag aaagcgtgca caggaacttt accttcagat gaaacaggag
     5821 ggagttgatg cggcagaagc agcctgtatc ctgattgagt atatgcatgg ggtattgatc
     5881 caggaggtgt ttcatgaaaa ggaacagcag acctacatcg atatgatgga ggaggcatgt
     5941 aattttctgg atgaaaaata ccaggagaaa ctgcaggctt cctatattga gggactttgc
     6001 gttctgcttc ttaagataaa ggattttaag cgcatgaaat actggtgcga taagagcagg
     6061 gaactctatc cggcagaatt atctacctat acctgttatt taaaacttta ttttacagag
     6121 ggaaacaaaa aacatttttt tgatgaattg gaaaaattaa aaaattcaga tattgtgatc
     6181 gacagggaaa cattggaatt aattcgtatt tttagctaaa ggaggtgatg gcagtgtcga
     6241 tgaaagtcct gactgtgtta cagtttatca gcattttcac aatttatacg ggacttttta
     6301 tcgcagttcc ggcactgctt ctgcaccgca ggttaaaaga tgaaatattt agtgtacggt
     6361 ttttctttta tatcgtatta ggtcatttct atctgatcaa tctggtatta tttcttcagc
     6421 tgcttcatat ttcaggcaga tttacgctga ttttgggcag tgcacttcca gttgttatat
     6481 ccttggtaca tacgaaaaga gtttcaccta aaaaaatcgg acatatcata ggaaacagaa
     6541 catcccatgt gatccgggag acgcttggca ttaaattact tcttctggag attgtacagt
     6601 ggattggcag aaaaattaag aaactgtgtg gcagaatgtg tgggctgatc atcaggcatt
     6661 ttgcagatgg agtgctgttt gttgtattta ctgcaacggt tctggtaatg tatggaacca
     6721 atatgataaa tacatacggt tattgtgcat ccgatatacc ggtacacaat tactggatca
     6781 atgcgatggg gcagaatgat gtgtttgtag ctggaattta tccatttgga ttccactgcg
     6841 taatttatta tatccatacg gtaacaggga ttgaaacgta tgtgctgctc cggctttttt
     6901 atgtggtgca ggtcttatat atccattatg cacttctggc atttttgaaa gcgtgctgca
     6961 ggacatcgta ttgcgcatgg ggagctgtat ttgtctatgt acttgctgca ttttttaaca
     7021 ggaatactta ctcgcgttat tacagttcgc tgcctcagga atttggcatg atatttatcc
     7081 tgcccggcat ttattttatg tatgcctttt taaaacagcg gaagatagaa gtgaatcaat
     7141 gcaacaagga aagaaatgct gccggattaa aaacctggaa atgcaaaagt acccgttatc
     7201 ttatgggatt tattgcagga tttggactta cgctgatcgt acatttttat gatactatgg
     7261 tagcagggtt gttttgtatc ggtattgcag gaggatacct gttgcgtatt ttcaaaaagg
     7321 agtatttttt cagggttctt gcgactggtc ttttaagtat cttcttggca gtgcttccga
     7381 tgggaattgc ctttttacaa ggtacgcctt tacagggatc gctgggctgg ggactcaatg
     7441 taattaatgg cagcaataat acgggtgctg aggaggaaga tgaagcagat atccctggca
     7501 gtgaaaagga agaaataaat acaaatacac agagtgtgac ggatcagagc atgacggaaa
     7561 gtacggatac tgccgggagc ataacggatc agacaatgtc agaaaatggt gtggaaaatg
     7621 cacagatgac agaagggacg caggtaaaaa caacaaggtt tggtatgctg gtggaaaaga
     7681 tacgtttccg gattacggat attacccaaa acggattgga ttatctgtgg acaggagtgc
     7741 acaatgttgt aatgcttcag gcaagcgtgc catggatgtt gtttattttt gggtgcgagg
     7801 gattctgcct gatcggtgga ctattgttta cgctcattgg aaaacatgat tatggatcaa
     7861 tgctgatgtc cgcaggattt ggtctgctgc ttttgatgat gtttctttct gcatggcgtt
     7921 ttggactgcc acatatcatg gatgcaagcc ggtgcagtat ctacgtcgct tatatgatac
     7981 cggtagcgat aggacttgga atggacggta tggtaacatt ggtctttgga ttttttaagc
     8041 ggaatatctg gatgaatctt gtttcactga tgacgtcagc ggcacttgtt gcgacacttg
     8101 tcaatggaaa tcagatccgt acaccgtcaa tattgacggc actgcagtcg aatgcggcga
     8161 ttacctgtct ggcaaatata aagcgggaga acgaaaagta taaatataca atctgttctg
     8221 cgaatgatga actgcgaatg atggaagatt atgcacgtca tgaggaaaca attacatttt
     8281 tacggagtat ggaaggagat gcggtcaatg gaaatctgac gctgccgaca gaccgcgtat
     8341 atttctttat tgagaagata ccacttgatt ataccgtggc atatgaggga agcggacagc
     8401 tcatttcaga agaaggagca aaaaaaccgc tgccaacagc aggagatatt tcggtttatg
     8461 aaggtgaaaa ccgatggatc gtaatgtcaa gaatgtatta ctgggcacag gcatttatgg
     8521 aactgtatgg aaaagaaatg caggtgtatt atgaaacaga tgattttatc tgctatgtgg
     8581 tagaacagaa tacctacagt ttatatgatt tttcaatcga ttatggatat aattgacaga
     8641 aaaaataatg gctgcaggat gagatggatt tggaaaggaa aatgtgatgg tatcccgaag
     8701 aaattttgct gcaatcacga tcatgttaat gattttactg tttatgtttc aatttacggg
     8761 tgtgatgaag gataaattaa gtaaatatgg gatcaatgaa tacaaggaaa gtgccacaac
     8821 ggaactgaca aaacaggata tgtatctggc atccgggcag aatatacaga aaacagcagg
     8881 tgtgctgtat attggaaaca gtgaggcagt aaagaatact gtaaaatggt ggtgtacata
     8941 tagcaaacgt gaatttcaga cagcggactc ttttgatggt atcgtgtcgg aagacagcag
     9001 gctgccggat attttggttt tagatggaac ctgtctgaat accagggata atataaaggc
     9061 ggtcagtgat gcagccgaaa agggagtaaa tgttatagtt tcaggactgc cggatgcaga
     9121 ggaaattgag aagaacgacc gtttgagaaa gctgcttgga atccgatatg tggaacagaa
     9181 tgaagtgaca cttgacggca tacacttgtt tgaaggattt ctgctcggcg gggaagtgat
     9241 ctatcaggca aaagatgagg aagaagagaa aaatcaggat atggatctta aaattccatg
     9301 gtatgtgacg ggggagggca caaaaagtta tatggtcgga atactctcag atgttcggcc
     9361 ggacagcgga agacagcctg ccattatatg gagaaacgga ctggaaaatg cctgtgtgtt
     9421 ttgcattaat ggaaattatt taaaggataa ttccggtatt ggcattctgg atgcaatgat
     9481 ggcagaatcg tattcgtttg agatttatcc ggtgatcaat gcacagaatc ttgtgattgc
     9541 aaattatcct ggatttgcgt cggaaaatga agataaaatg gaaaaaatat acagtcagtc
     9601 acaaaaggca ttatttcgag aaatcatctg gccgtcgctg gtcgcaattg aacgaaagat
     9661 cgatgcaaaa ctgacctgta tgatgacacc gcagtttgat tatggagatg aaaatgagcc
     9721 acgggaggga gaagtggcat attatctgaa attattgaaa gaagaatacg gggaggcagg
     9781 actttcatcc ggcaatgtat ctggaaccgg gctgtcggaa aaaatggaga aagacgaaac
     9841 gttttggaaa aaagaggcac cagattattg ttttcagtca ttatacctgc aaaatgaaga
     9901 cgaactgggg gatgctttgg aatgcgagga acttgatgga ataaggacga ttgtaaccag
     9961 ggaatcacag accagcgacg aaccgatcgt ttcctttgca ggggaagagg tgacactgca
    10021 gcgtgctacc ggagatggtg tgaatcatac atttatggat gatttcagac agagatgtat
    10081 ccagaccgca ttggggtatt cgaatacggt atgggatctg cttgcagcag catatccgga
    10141 gaaaaaggat gatgcgtggg agatcctttc gaaggaagca gcgtctaata tctgtactta
    10201 tcagaaaccg tttacggcat ttgatgagac aacgatctca aagagcgatc agaggataag
    10261 gagatttctg gcactttctt attcagcaga atctgaagat aatatgattt ccctgcatgt
    10321 tgacggatta gaagaggaag cgtggttttt actgcatacg ggaacacgcg aagcagagga
    10381 tatacaggga ggaagttttt ctgtagtgga ggatggtgtt tacctgatct gtgcagaaga
    10441 ggatgaggta aaaatccggt tgagtgagga agaagaaaag caattgtttt attacgagga
    10501 ttgaaaatga aagtatgtat tgtagcagag ggatgttatc cttatgtggt gggcggtgtt
    10561 tccagttgga tcaacagtat gataaaagct tttcccgaca tagaattcgt ggtgcttgcg
    10621 attgtagcaa accgttcata cagaggaaaa tttgtttatg aactgccgga aaatgtgtcg
    10681 gaagtttatg agctttatct ggaagattat gactgggtag agcaggaaaa aaataaaaaa
    10741 ctgcatctgc gtcagaatga atatgaggca ctgcggtcat tacttttaaa ccggaatgtt
    10801 gagtgggata cgttgtttac gttgtttgaa aagaaaaatt tttcattgaa cgcgcttttg
    10861 atgggagaag attttttaaa tgctgtgcgg gaatgttatc agctcagata tccacaggtt
    10921 gttttttctg atttcctctg gaccatgcgt tccatttatc tgccactgtt tctgaccttg
    10981 aaaatggaac tgcccgaggc ggatctttat cactgtgttg cgaccggata tgcgggagtg
    11041 atcggaagca tggcaaaaaa aagatatgga tgcggactaa tggtttcgga gcatggaatt
    11101 tataccaggg agcgggagga ggagctgatc cgtgcaaagt gggtaggcgg tatctataaa
    11161 aatatctgga tcgaacagtt taaaaaaatg tccctgctcg cataccggta tgcagatcag
    11221 gtaacctgtc tttacaagca tgccatggaa cttcagatcg aactcggatg tccggcagaa
    11281 aaaataaaga tcacaccgaa cggtattgat gatcagagat ttgtcagatg ccttgaagaa
    11341 gagagaagag aagatgacac catcaatatc ggagcggtgt taagaattgc gccgatcaag
    11401 gatgtcaaaa cgatgataag agcctttgct tatgccaaga aagaggcacc aaaactcgca
    11461 ttgtggatca tgggaccatc cgatgaggaa aaagaatatg ccaaagaatg ttttgaactg
    11521 gtggatcttc ttggcgtgga ggatgtgatc tttaccggaa aagtcgatgt gacagaatat
    11581 cttgggaaga tggatatgac catactcaca agcatcagtg agggacagcc actgacgatc
    11641 ttagagagtt ttgcggcaaa aaaaccggtg attgcaacgg atgtaggcaa ctgcaggggg
    11701 ctgatctacg gggaaggcga ttcatttggg gatgcaggga tcattacaca tatcatgaat
    11761 gtggaggaga ttgcggcagc gatggtagat ctggcatgcc acagagaaaa gaggattggc
    11821 atgggaaaaa acggataccg gagactaaag agccggtatc ttgtggagga tatgaaagaa
    11881 acataccggc agatttaccg gcaatttgag gatgaaggca gagtgcaggg aaagaaaggg
    11941 gatgtgtgat ctatggcagg aataggcgta aaacttcaga aaatttatga caggcgcacg
    12001 atccttgcaa atctggcagg attcggttac agtaccatgg tcacgatcgc ccccatgttt
    12061 gtcgtgatcg gaaatgtgat gttaatgagc cattttcttg gatacgagac agtagggtat
    12121 gcgagaagag gattattttc aggcacggta ctttatattt ttatattttc cctgctggtt
    12181 gcggcaccgt ttaatgctgt attatcgaga tatatgtccg atattattta tgaggaaaag
    12241 tacgaagata tcctgccatg ttatgatgtc ggattatttt taaatatttg tttcgggtgt
    12301 ctgtttgcaa tcccgttctg tatcagggag tatctgaagg ggcaggtgga tctggtgttt
    12361 gtgtttaccg ggttttgcgg ctttatatcg cttcttctgg tattttattc catgctgtat
    12421 ctgtcgatct gcaaggacta tcagaaaata tcattatttt tcctgatggg tatggcagcg
    12481 gcatttgggc ttgcgtggct gctcgtgaaa gtgtttcaca gggacatcat atacagcatg
    12541 cttctttcac ttacgatcgg atttttcctg acggcggcga tatcagcggc aacgattaag
    12601 agttatttta aaaggaacag ccgccagtac cgcaaggtgc ttcattattt caaaatttac
    12661 tggcacctta ttgcgacaaa cctattgtat acgttaggat tgtatataca taattttata
    12721 ttctggacga cggacttaaa gatgacggtg gcacatacgt ttgtctatgc gcctgcatat
    12781 gatatggcga cctgtctggc aatgtttacg aatctttcgt cgaccatcat ttttatcagc
    12841 cgcgtggaaa tgcattttca tgagaggtac aaggcatatt cggaggctgt tatcggtggc
    12901 agatgggaag atatcaataa tgcaaaaaac agaatgttcc gccagcttgc atctgaactt
    12961 atgaatcttg tgagaatcca gtttattgtc tcggtcgtgc tttatctgct ctgtgtgata
    13021 tttttgccgg gaatgggctt ttcaggactt gtgatgcaga tttatccgtg tcttgcagcc
    13081 ggttacttta ttcttttttt gctgtatgcg gaactgattt
//
