LOCUS       c00019_gnlPro..        14699 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|OMKAEKNI_19.
ACCESSION   c00019_gnlPro..
VERSION     c00019_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-05 02:46:24
            Original ID  :: gnl|Prokka|OMKAEKNI_19
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14699
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14699
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[442:4699](+)"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /neighbourhood="10000"
                     /product="Others_HGD_unassigned"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      443..4699
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /neighbourhood="10000"
                     /product="Others_HGD_unassigned"
                     /protocluster_number="1"
     cand_cluster    1..14699
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /kind="single"
                     /product="Others_HGD_unassigned"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14699
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Others_HGD_unassigned"
                     /region_number="1"
                     /rules="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D, HleuD1,
                     HleuD2, HleuS1, HleuS2, Lactoyl-CoA1, Lactoyl-CoA2]) and
                     minimum(1, [ACP_syn_III, ACP_syn_III_C, AcetylCoA_hyd_C,
                     AcetylCoA_hydro, Acyl-CoA_dh_1, Acyl-CoA_dh_2,
                     AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG, Biotin_lipoyl,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_6_Glutaconate, CoA_transf_3, ECH_1, ECH_2, ETF,
                     ETF_alpha, FGGY_C, HCDH, HCDH_N, Hacid_dh, Hacid_dh_C,
                     Mal_decarbox_Al, Peptidase_M22, Peptidase_M23, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and not (minimum(2,
                     [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /tool="gutsmash"
     CDS             complement(3..188)
                     /locus_tag="ctg19_1"
                     /transl_table=11
                     /translation="MNWLNKLERKIGRYAVPNLIIWLIGAYTIGYVFGTVSPGILSYLT
                     LSPYHILHGQIWRLVTW"
     CDS             443..4699
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: HGD-D"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: BcrAD_BadFG"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg19_2"
                     /sec_met_domain="HGD-D (E-value: 6.7e-60, bitscore: 194.4,
                     seeds: 370, tool: rule-based-clusters)"
                     /sec_met_domain="BcrAD_BadFG (E-value: 3.7e-38, bitscore:
                     122.4, seeds: 18, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MENNTLHKLGIDIGSTTVKVAVLDEHDNLLFSDYERHFANIRETL
                     SSLIQKAFDQLGDRKVAPMITGSGGLTLAKHLDVPFVQEVISVSTALQHYAPQTDVAIE
                     LGGEDAKIIYFEGGNVEQRMNGICAGGTGSFIDQMASLIQTDASGLNEYAKNYKAIYPI
                     AARCGVFAKTDIQPLINEGATREDLSASIFQAVVNQTISGLACGKPIRGHVAFLGGPLH
                     FLSELKVAFIRTLNLDDEHAITPDNSHLYAAIGSALNCKPEQNTTLSSMLEKLNSDIHM
                     EFEVARLDPLFKYQAEYDTFRARHDGHNVKTGDLSTYEGNCYLGIDAGSTTTKIALVGE
                     DGSLLYSFYSNNNGSPLSTAIRSIKEIYEKLPANAHIVHSCSTGYGEALLKAALMLDDG
                     EVETVAHYYAAAFFDPEVDCILDIGGQDMKCIKIKNQTVDSVQLNEACSSGCGSFIETF
                     AKSLNFSVQDFAKEALFAKNPIDLGTRCTVFMNSKVKQAQKEGASVADISAGLAYSVIK
                     NALFKVIKLSDASELGKNIVVQGGTFYNDAVLRSFEKISGCECVRPDIAGIMGAFGAAL
                     IARERHEADYQTTMLSIDEINALTFDTKLARCQGCTNHCLLTINRFSGNRQYITGNRCE
                     RGVGGVKNKENIPNLFEYKNKRLFDYPSLKPEEALRGTVGIPRVLNMYENFPFWATFFK
                     KLGFSVVLSPQSTRKIYELGIDSIPSESECYPAKLAHGHVTWLIHQNVDFIFYPCVPYE
                     RNEFPDSNNHYNCPIVTSYAENIKNNVEDITSGKVRFYNPFMAFTSEETLSSQLVKTFG
                     APEFAIPESEIRDAVSEGYKELAVVRMEMQKKGEEVLAYMEKTGKRGIVLAGRPYHVDP
                     EINHGIPELINSYGIAVLTEDSVSHLHQVERPLIVMDQWMYHSRLYAAANFVKTRDDLD
                     LIQLNSFGCGLDAVTTDAVNDILTKSGKIYTCLKIDEVNNLGAARIRIRSLLSAIRVRE
                     KKQTKRTIIPSNYNRVVFTEEMRKNYTILCPQMSPIHFELLEPAFCAAGYNLVVPDVPS
                     RTCVDVGLKYVNNDACYPSLIVVGQLMSAVMSGNYDMNKTAILISQTGGGCRASNYIGF
                     IRRALEKAGYPNVPVISINLSGLESNPGFKLTPSLIQHGLYALEFGDIFLRCLYRTRPY
                     EAVKGSANALHEKWKKEVISFITQDKLLSHRKFKQMCRQIIRDFDNLDRVDVKKPRVGV
                     VGEILVKFHPAANNDLVGLLESEGAEAVVPDLTDFLLYCFYNTGFKADNLGFSKKSKRI
                     GRLGINFFEWLRSAARDEFEKSKHFDPPAHIDDLANYARDIVSEGNQTGEGWFLTGEMM
                     ELIHSGTPNIVCTQPFACLPNHVVGKGVIKELRHRFPESNIVAIDYDPGASEVNQLNRI
                     KLMLSTANKNLAKQSL"
     CDS             complement(4694..4804)
                     /locus_tag="ctg19_3"
                     /transl_table=11
                     /translation="MLSGNNIYRDTKEKQPHPISAAVKTVMHDDKSVCDL"
     CDS             complement(4788..5384)
                     /locus_tag="ctg19_4"
                     /transl_table=11
                     /translation="VKNMITMMIGIVIGAITILIILTVTGRMNYATELESQLPAVVENI
                     LCNVKIKQLYNVADNQEFTADVTEQIAKELDAQTGIVMRIMGADKEKGLFSVGVDRTFV
                     HPNGKNGTVKCSRTVLADKLQIVEIQKYYVQFYKDADNSECYKKYCVTEGDTISAPAVP
                     EYKDREFAGWQDDKGYEADFSQPVEQNRNYYAVWK"
     CDS             complement(5404..5856)
                     /locus_tag="ctg19_5"
                     /transl_table=11
                     /translation="MHEVIKVYGKTILQAIILVGVMWLVFRGVTDENGNKGIVEIVSGH
                     MDRQTENPADFETFYEESQKAPPHFETAITGYLKIGTYQMTDIIKAWDYAENELQIQLM
                     KVISPDGTVLENKLDFQMPGVYEVSVMTEDHDNRVRYAVVNIPVNE"
     CDS             complement(5866..6015)
                     /locus_tag="ctg19_6"
                     /transl_table=11
                     /translation="MEDIIEEFGSGFLTITVTLFLVGYWYENMRQGGAVYEFVQQFLNC
                     ICGG"
     CDS             complement(6158..6493)
                     /locus_tag="ctg19_7"
                     /transl_table=11
                     /translation="MRQIIGAFGILFIMMANIFICTGLIGASGQVAAAKEYKSQVVAEL
                     ENSNFNPGVIDACKKKAAEDGYELEISDCVYDAWQNMRAAQVALKYHYRIPVLGIYEEN
                     ITYAIAR"
     CDS             complement(6490..8013)
                     /locus_tag="ctg19_8"
                     /transl_table=11
                     /translation="VGWLTFWNPKNLQKKVDMYGYHFSWKTHAVMIFLALAGVIGIGAV
                     FRLKAGGVVIALTAVIMMLPVLVLDMYHKMYEQKRFADAAEYMEQMLYAFQKTGKILSA
                     LKETREIFEEGKMRSCIEQVILKLEFGDFSAGENVFESALEPIESQYQCPKIKMLHELL
                     INAEEHGGEMSESALLLLEDIELWKRRGYQLQAEKKKSHTDNIISVIVSVILCATALYV
                     LDSMKDLFVVKTDFNIFGVGIIQVSSLVFLLFLLWVFVKSSRNLTNDWLATEKVEKEQE
                     ISSSCEMVYHYNEKKEKRKSMLWALPAAGMMLAAVLAGKLILAGILFPVTLFLAMQHKV
                     GYQIAKRDVKEAVYLALPGWFMELALLLQNNNVQVSIEKSKNSAPPVLRYEIECLEERL
                     KKTPEKLSAYTEFCKEFDVPEAQNCMKMLHAVAEMGTGDAVTQMNHLIMHVNEMQNRAE
                     EIRNGKIAFRQKMIFSYPVIAATVKLLIDLTVGMIMMFHMLGSMGGAVQ"
     CDS             complement(8030..8677)
                     /locus_tag="ctg19_9"
                     /transl_table=11
                     /translation="MNLVFGGEPGAGKTECAKFFMQFIRKEERVITIEDSLEIHYANIN
                     PGADAVELRVGKGFDYTDAIKASLRQNPSWLMLSEARSVEVTSLLEQWSTGVHGFTTIH
                     LDDVRKLPDRILNMMNNVNDAQRMENRIYRYVNAAVLIRKIESSDGKVRRYIDQLCFFS
                     REEGKNRIYMIVDDGALVSKELPPDIKKRFRETGVEEPFVCRQFETYLKENR"
     CDS             complement(9138..9305)
                     /locus_tag="ctg19_10"
                     /transl_table=11
                     /translation="MEQVMKHYGNAILAVIVLLALGAIIVAALSSDGYVAMEFKNTLTG
                     FFDNMNALRP"
     CDS             complement(9293..9886)
                     /locus_tag="ctg19_11"
                     /transl_table=11
                     /translation="MSVKIAFWGMEESCHITENMIVMSWLLAKIRPAHSIFVHRENGWQ
                     CIFSGGKDRILFADCGCGRDKKTQNSLKNADVIVAGIHTYPSEWQEIIHNFTVRHKKVL
                     YLVEGYALHASRLKTDMMDRYRIAPEQIGYIPQNGELEWVSAQGKIDNFMKSWRQKSRT
                     ERNENFFEEMEHNLFLLMKQMEKNENGGYLLWNR"
     CDS             10428..11171
                     /locus_tag="ctg19_12"
                     /transl_table=11
                     /translation="MPVKEFYDKMRAGSLPTTSQANPEEAATLYESILKENDVDILHIA
                     FSSGLSGSFNSCRIAAADVCEKYPDRRIVVVDSLAATLGQGLLVYKAVQLKEAGKNLDE
                     IAAWLEENKYHLVHNFTVDDLFHLHRGGRLSKTAAIVGTMINLKPVLHVDDEGHLVMLS
                     KVRGRKKSLIGLVDCMEKQLGDWKDKNDIIFISHGDCPEDAQFVADLIKERFGYENFMI
                     DYIGATIGAHSGPGTVALFYMGDHR"
     CDS             complement(11247..11525)
                     /locus_tag="ctg19_13"
                     /transl_table=11
                     /translation="MKTISREEFEKRNVFGTGAENTGFAQYFIGNSYLNPLTDPKNCAV
                     FMANVTFEPGCRNNWHIHHAAKGGGQLLICTAGEGWYQEEGKEAFEK"
     CDS             complement(11631..11945)
                     /locus_tag="ctg19_14"
                     /transl_table=11
                     /translation="MILVNTDYISGKNLEMLGLVKGSTIQSKNIGKDITQSFKTLVGGE
                     LKAYNEMMNEARALATKRMVEEAESLGADAVVNIRYASSAVMQGAAEVIAYGTAVKFTN
                     "
     CDS             complement(11926..12159)
                     /locus_tag="ctg19_15"
                     /transl_table=11
                     /translation="MKKEHRNKMIAPIIIAAVLIVYYVAIAAVFMLIPDLTVIMKLLMV
                     IIPLALAGVAFAVTVERVQEIRSGEEDDLSKY"
     CDS             complement(12219..13490)
                     /locus_tag="ctg19_16"
                     /transl_table=11
                     /translation="MKPDYYEDFTCIADRCSFTCCREWKIGVDEDTFVKWKHTLTPDGM
                     YDTDRGQQAKKEKLSGYVRKKDGSRVIGLNKEKNCPFLNGKKLCRLVLTYGDEILSQTC
                     QLFPREIHTFNEDVTEYALMPSCPAVIDLLRKREHISFSGEMDTSAYRELAPLVNLRAF
                     LMKLMEDGAHTPEHNLMKIFYVLLDLYERVEDEQAKDGCMENKQVKDAAEDALGLDLTD
                     MAKMYPGGFLLELSETIDGIEQTLQYSIEERNELFLDLAENYRREGLYEKYLEPVAQLA
                     EQLSEQGIDEEVVKEWREFEVQFLKYQPLMRRFLLTELYADSLKPEGNLEEMVVQVQWI
                     AMEYATIRHAVFLHWLLSQGEGSFCEEGISTSCRRGISYEDVRDYMVVVSRMTGYEEDD
                     IYEYLENSFEHIIWDWGYFALICG"
ORIGIN
        1 acccatgtca ccagtctcca gatctgtcca tgtaaaatat gatagggact gagtgtcaga
       61 tagcttaaaa taccaggcga tacggttccg aatacatagc cgatcgtata ggctccgatc
      121 agccatataa taaggtttgg aacagcgtaa cgaccaattt tacgttctaa tttatttaac
      181 cagttcatcg gataaaaccc taacctttct ttgaaaacac tacttttttc agtatatccg
      241 tatgcctgtg ctttgtcaat ccaggctgat tttattcata aaaagtttat atttttcccc
      301 gatttgcaca ttgtcttttg taaaatcatg tcgtataatg tactttgctt ggcttttgcc
      361 cggcattctt tttaataaga agaaacagcc actttattta tatattatcc ggattttccg
      421 gagttactga ctggaggaaa ttatggaaaa taatacgctt cacaaacttg gaattgatat
      481 cggttctacc accgtaaagg ttgctgtgct cgacgagcat gacaatctgc tcttttccga
      541 ttatgaaaga cattttgcca acatacggga aacgctttct tctctgatcc agaaagcatt
      601 cgatcagctc ggtgaccgga aggttgctcc aatgatcacc ggttccggcg gacttacact
      661 tgcaaagcac ttagatgttc ctttcgtaca ggaagttatc tctgtgtcta ccgccttaca
      721 gcactatgct ccacagacag acgttgcgat cgagctcggc ggtgaagacg caaaaattat
      781 ttattttgag ggcggtaacg ttgaacagcg tatgaacggt atctgcgcag gcggtaccgg
      841 ttcttttatt gaccagatgg cttccctgat tcagacagat gcctccggtc tgaatgaata
      901 tgcgaaaaat tacaaagcaa tctacccgat tgcagcccgc tgcggtgttt ttgccaaaac
      961 agacatccag cctctgatca acgaaggtgc cacaagagag gatctctctg cttctatttt
     1021 ccaggcggtg gtaaaccaga cgatcagtgg tcttgcctgt ggtaagccga tccgcggcca
     1081 cgttgcattc ttaggtggtc cgctccactt tttatctgag ttaaaagttg catttatccg
     1141 caccttaaac ttagatgatg agcatgcgat cacgccggac aattcgcacc tttatgcagc
     1201 gatcggttct gccttaaact gcaaaccgga acagaatacc actctctctt ccatgcttga
     1261 gaaattaaac tctgatatac atatggaatt cgaggtagca cgtcttgatc cgttatttaa
     1321 atatcaggca gaatacgata ccttccgtgc ccgccacgac ggacacaatg taaagacagg
     1381 tgatctttcc acctacgaag gcaactgtta tctcggtatc gacgccggtt ccacaacaac
     1441 aaagatcgct ctcgtcggcg aggacggttc cctgttgtat tcattttaca gcaacaacaa
     1501 cggaagcccg ctttccactg cgatccgttc catcaaggag atctatgaaa aacttccggc
     1561 aaatgcacat atcgtacact cctgctctac cggttacggt gaagctctct taaaagcagc
     1621 gctgatgtta gacgatggtg aagtagaaac ggtagcacat tattatgcag cggcattttt
     1681 tgatcctgag gtagactgta tcttagacat cggtggtcag gatatgaaat gtatcaagat
     1741 caagaaccag acggtagaca gtgtacagtt aaacgaagcc tgttcttccg gctgtggttc
     1801 ttttatcgaa acatttgcaa aatccttaaa cttttctgta caggacttcg caaaagaagc
     1861 tttatttgcc aaaaatccga ttgatcttgg aacacgctgt actgtattta tgaactccaa
     1921 agtaaagcag gcacagaaag aaggagcttc cgtagcagat atctctgccg gacttgccta
     1981 ctccgtcatt aaaaatgctt tatttaaggt tatcaaactc tccgatgcaa gtgagctcgg
     2041 aaaaaatatc gtcgtacagg gtggtacttt ttacaatgat gccgtgctcc gcagttttga
     2101 aaagatttcc ggctgtgaat gtgtccgtcc ggatatcgca ggtatcatgg gtgctttcgg
     2161 agctgctctc atcgcaagag aacgtcatga agctgactat cagacaacga tgctttccat
     2221 cgacgagatc aatgcattaa cttttgatac caaacttgca agatgtcagg gttgtaccaa
     2281 ccactgtctg ctgacgatca accgtttctc cggaaaccgc cagtatatca cgggaaaccg
     2341 ctgtgagcgc ggtgtcggcg gcgtaaaaaa caaagaaaat attccgaact tatttgaata
     2401 caagaataaa cgcttattcg actacccttc cttaaagccg gaagaagccc tgcgtggaac
     2461 ggtaggtatc ccaagagttt taaatatgta cgagaatttc ccgttctggg ctactttttt
     2521 caaaaaactc ggattttccg ttgtactgtc accacagtcc accagaaaaa tctatgagct
     2581 cggcattgac tcaattccaa gtgaatccga gtgttatccg gcaaaacttg cacatggaca
     2641 tgtgacctgg ctgatccatc agaatgtaga ctttattttc tacccatgtg taccttatga
     2701 gcgcaatgaa tttccggatt ccaacaacca ttacaactgc ccgatcgtaa cctcctacgc
     2761 ggaaaatatc aaaaataacg tggaagatat cacttccggc aaggtacgtt tttataatcc
     2821 attcatggca tttaccagcg aagaaacttt atcttcccag cttgtaaaaa cctttggtgc
     2881 accggaattt gccatcccgg aatcagagat ccgtgacgct gtttccgaag gttacaaaga
     2941 acttgctgtt gtccgcatgg aaatgcagaa aaaaggtgaa gaagtcttag cttatatgga
     3001 gaaaaccggc aaacgcggta ttgtattagc aggacgtcca taccatgttg accctgagat
     3061 caaccacggt atcccggaac tgatcaattc ctatggtatt gccgtactga ctgaggactc
     3121 cgtttctcac cttcatcaag tggaacgccc tctgatcgtt atggatcagt ggatgtatca
     3181 ttcccgtctg tatgcggctg caaactttgt aaaaaccagg gatgaccttg atctgatcca
     3241 gttgaactcc ttcggttgtg gcttagacgc agttaccacc gacgcagtca acgacatcct
     3301 gacaaaatca ggcaagatct acacatgctt aaagattgat gaggttaaca acttaggtgc
     3361 tgcaaggatt cgtatccgtt ccctgctctc cgccatccgt gtgcgtgaga agaaacagac
     3421 aaaacggaca attattcctt ccaactataa cagagttgtt ttcacggaag aaatgcgtaa
     3481 aaattataca attctctgtc cgcagatgtc accgatccac tttgagctgt tagaacctgc
     3541 attctgtgca gccggttata acctggtggt accggatgtt ccaagccgca cctgtgtgga
     3601 tgtcggatta aaatatgtaa ataatgatgc ctgctatccg tcactgattg tggtcggaca
     3661 gcttatgagt gctgttatgt ccggaaatta tgacatgaac aaaaccgcga tcctgatctc
     3721 gcagaccggc ggaggctgtc gtgccagcaa ctacatcggt tttatccgtc gtgctcttga
     3781 aaaagcagga tatccgaatg taccggtaat ctccatcaac ttaagcggac ttgaaagcaa
     3841 tcctggcttt aaactgacgc cttcactgat ccagcacgga ctatatgcat tagagtttgg
     3901 cgatattttc cttcgctgtc tgtaccgcac acgtccttat gaagcagtaa aaggatctgc
     3961 gaatgcactg catgagaaat ggaaaaaaga agtaatctcc tttatcacac aagataaact
     4021 gttgtcccac cgcaaattta agcagatgtg ccgtcagatc atccgcgatt ttgacaacct
     4081 tgaccgtgta gatgtgaaaa aaccgcgtgt cggcgtcgtt ggagagatct tagtaaaatt
     4141 ccatcctgct gcaaacaacg atttagtcgg attgttagaa tccgaaggcg cagaagctgt
     4201 cgtgccggat ctgaccgact tcctgctcta ctgcttctat aacaccggat ttaaggctga
     4261 caacctcggt ttcagcaaaa agtccaaacg cattggacga cttggcatca atttctttga
     4321 atggttaaga agcgctgcca gagatgaatt tgaaaagagt aagcattttg atccgcctgc
     4381 tcatatcgac gatcttgcaa attatgcaag agatatcgta tccgaaggta accagaccgg
     4441 tgaaggatgg ttcttaaccg gcgagatgat ggagctgatc cacagtggta caccaaacat
     4501 cgtctgtaca cagccatttg cctgcctgcc gaaccacgtt gtaggaaaag gtgttatcaa
     4561 agagctgcgc caccgtttcc cggaatcaaa tatcgttgcc attgactacg atccgggtgc
     4621 aagtgaagta aaccagttga accgtatcaa actgatgctc tcaactgcaa acaaaaatct
     4681 tgcaaagcaa tctttataaa tcacacacag atttatcatc atgcattacc gttttcacag
     4741 ccgcgcttat agggtgcggc tgtttttctt ttgtgtctct gtaaatatta tttccagaca
     4801 gcataataat tccggttctg ttcgaccggc tgtgaaaaat ctgcctcata tcccttgtcg
     4861 tcctgccagc ctgcgaactc cctgtctttg tattccggca ctgcgggtgc actgatcgta
     4921 tctccttccg tcacacagta ctttttataa cattcactgt tatctgcatc tttataaaac
     4981 tgtacataat atttctgaat ttctactatt tgcaacttgt ctgccaatac agtccggctg
     5041 catttcacag taccgttttt tccattcgga tgcacaaacg ttctatctac tcccacagaa
     5101 aatagtccct tctccttatc agctcccatg atccgcatta caataccggt ttgggcatcc
     5161 agctcctttg caatctgttc tgtcacatcc gcggtaaatt cctgattatc ggctacatta
     5221 tacaactgtt ttatctttac attacaaagt atattttcta caaccgccgg aagctgactt
     5281 tccagctctg tagcgtaatt catacggccg gttaccgtta atattatcag aattgttatt
     5341 gcaccaatta cgattccaat catcatagtt atcatatttt tcacttttcc caccctttat
     5401 ctgtcattca tttaccggta tatttaccac ggcatatctg actctgttat catgatcttc
     5461 tgtcatcaca cttacttcat acacccccgg catctgaaaa tccagtttat tttccagcac
     5521 tgttccatcg ggtgaaataa ctttcatcaa ctgtatctgc aattcatttt ctgcataatc
     5581 ccacgccttt ataatatctg tcatctgata tgttccaatt ttcagatatc ctgttatggc
     5641 tgtttcaaaa tggggtggtg ctttttgtga ttcctcataa aacgtttcaa aatctgccgg
     5701 gttttccgtc tgccgatcca tatgaccaga tacgatctca acgattccct tatttccgtt
     5761 ttcatccgtc actcccctaa aaacaagcca cattaccccc acaaggatta tcgcctgaag
     5821 aattgttttc ccataaactt tgatcacttc atgcatatcc acctcctatc cgccacagat
     5881 acaattcaga aactgctgca caaattcata aacggctccg ccctgcctca tattttcata
     5941 ccagtaacca actaaaaaaa gtgtcacggt aattgtcaga aatccacttc caaattcctc
     6001 aatgatatcc tccatctgct ttccctttcc tgtgttcttt aaaaagatga cacataattt
     6061 aaaatttcat aaaacattct tatcactgca ctgccagcca aaatccccag aaacgctccg
     6121 ccaaattttt ccacgatcat cataaggctc aaatctatca cctcgcaatc gcatatgtaa
     6181 tattctcttc gtaaattcca agtaccggta tgcggtaatg atactttaat gccacctgtg
     6241 cagccctcat attttgccat gcgtcataaa cacaatccga aatctccagt tcatatccgt
     6301 cctctgccgc cttcttttta caggcatcga tcacacccgg attaaaatta ctgttttcca
     6361 gttccgcaac cacctgtgat ttatactctt ttgcagcagc aacctgccca ctcgccccga
     6421 tcagacctgt acatataaaa atatttgcca tcattataaa taaaatacca aatgccccga
     6481 ttatctgcct cattgcactg cacctcccat acttccaagc atatgaaaca tcattatcat
     6541 tccaactgtc agatcgatca gaagttttac ggttgccgct ataacaggat aagaaaatat
     6601 cattttctgt ctaaatgcga tttttccatt tcggatttct tctgcccggt tctgcatttc
     6661 attcacatgc atgatcagat gattcatctg tgtcactgca tccccggttc ccatctccgc
     6721 aacagcatga agcattttca tgcaattctg tgcttccggc acatcaaatt ctttgcaaaa
     6781 ttctgtatat gcactcagtt tttccggcgt tttttttaat cgctcctcca gacattcaat
     6841 ctcatatctg agcaccggcg gtgcactatt ttttgacttt tcgattgaaa cctgtacatt
     6901 attattctgc aataacagag caagttccat aaaccagccc ggaagagcca gataaacagc
     6961 ctccttcaca tctctttttg caatctgata ccccacctta tgctgcatgg ctaaaaaaag
     7021 cgtcaccggg aataaaattc ctgcgagaat aagttttccg gccaatacag cagctaacat
     7081 cataccagcc gccggcaatg cccataacat actttttctt ttttcctttt tctcattgta
     7141 atggtacacc atttcacagc ttgaactgat ttcctgttct ttctccacct tctctgtggc
     7201 tagccagtca ttcgtcagat tcctcgaact ctttacaaat acccataata ggaaaagcag
     7261 aaatacaagt gatgagacct gaatgatccc tactccaaaa atattaaaat ccgttttcac
     7321 cacaaaaaga tctttcatgg aatctaacac atacaatgcc gtcgcacaca aaataacgga
     7381 tacaatcaca gaaataatgt tatccgtatg actttttttc ttctctgcct gaagctgata
     7441 gcctctgcgc ttccacaatt cgatatcttc taacaggagc agtgcagact cactcatctc
     7501 tcccccatgt tcctcggcat tgatcaaaag ctcatgaagc atttttattt tagggcattg
     7561 atattgactt tcaatcggtt ctaatgctga ttcaaagaca ttttctcctg cagagaagtc
     7621 tccaaattcc agtttcagaa tcacctgctc aatacaggaa cgcatcttcc cttcttcaaa
     7681 tatttctctg gtttccttta atgcacttaa aatttttcct gttttctgaa atgcatataa
     7741 catctgctcc atatattccg cagcatccgc aaatcgtttc tgctcgtaca tcttatggta
     7801 catatccagc accagaaccg gaagcatcat gataaccgcg gtcaacgcga tcacaacgcc
     7861 gcccgcttta agccggaaca cggcacctat gccaatcacc cctgcgagtg ccagaaaaat
     7921 catcactgca tgggttttcc acgaaaaatg atacccatac atatccactt ttttctgcag
     7981 atttttcgga ttccaaaaag tcagccaccc cacgatacat cctctccttt catcggttct
     8041 ctttaagata cgtttcaaac tgtctgcata caaaaggctc ctccacgcct gtttccctga
     8101 accttttttt gatatccggc ggcaattcct tcgatacaag cgccccatca tcgacgatca
     8161 tataaattct gtttttccct tcttcacgcg aaaaaaaaca tagctgatct atataacgtc
     8221 tgacctttcc atcggaagat tcgatttttc ggatcagaac tgctgcattc acataacggt
     8281 aaatccgatt ttccatacgc tgtgcatcat tgacattatt catcatattt aatatccgat
     8341 ccggaagttt tctcacatca tccagatgga tcgtcgtaaa tccatgaacg ccggtgctcc
     8401 attgctccaa caatgatgtt acctccacag agcgcgcctc cgagagcatc agccagcttg
     8461 gattctgacg cagtgaggct ttgattgcat ctgtataatc aaatcccttt ccgacacgaa
     8521 gttcaaccgc atctgcaccg ggattgatgt tcgcataatg gatctccaac gaatcttcta
     8581 tcgtgataac acgctcttcc tttctgataa actgcataaa aaattttgca cattctgtct
     8641 tgcctgcccc cggctcccct ccaaaaacaa gattcatctt cgcctgcaca caatttaaca
     8701 gcagatgcag cacttctttc tcacagtact tctgatccag cagattctct aaggtatttc
     8761 ttacaaaaca cggggattta cggatacaga tgctgatccc cgatatcgcc gccgactcat
     8821 gaataatact gattctcagt tcttttgtat ccgcttccag tattttgttt gcattattaa
     8881 attgtttatt gatacaattt gagatattgt gtgtaaatgt actgataaaa tattccggta
     8941 tctcctcatt tgcacagtac ctcccctctt tcagatctgt gatccataat ttttgcccat
     9001 tatagtctac atccgtcacc tccggtctgc ttaaatattt ccagaatatc ccgaactgtt
     9061 ccggtgtggg ttcaaaaata atcttttcac tcatcttttc cagattctat ctccttctcc
     9121 attttctttg cctcttccta aggacgaagc gcattcatat tgtcaaaaaa accggtaagt
     9181 gtattcttaa attccattgc aacatatccg tccgacgaca atgccgccac aatgatcgca
     9241 cctaatgcca ataatacgat taccgcaaga attgcatttc cataatgttt cattacctgt
     9301 tccataatag atatcctcca ttttcatttt tttccatttg tttcatgaga agaaacagat
     9361 tatgttccat ttcttcgaaa aagttttcat tacgttctgt tctcgatttc tgtctccatg
     9421 acttcataaa attatcaatt tttccctgcg ctgacaccca ctccaattcc ccgttttgcg
     9481 ggatatagcc tatctgttcc ggcgcaatac gatacctgtc catcatatcc gtctttaacc
     9541 ggcttgcatg caatgcatag ccttcgacca gataaagaac ctttttgtgt ctgactgtaa
     9601 aattgtgtat gatctcctgc cattcactcg gataggtatg gatccctgcg acaataacat
     9661 ctgcattttt taaactgttt tgtgtttttt tgtctctgcc acatccacaa tctgcaaata
     9721 aaattctgtc ttttccaccg gaaaaaatac actgccagcc attctcccta tgcacaaaaa
     9781 tactatgtgc cggtctgatt tttgccagaa gccatgacat cacaatcata ttttctgtta
     9841 tatggcagga ctcttccata ccccagaatg ctatttttac agacatgtcc gctccttttt
     9901 cccattacaa aaaaggcggg atatccctct gaaacagcct ttggcaataa aaattgttct
     9961 gtgaaataaa gtgacaataa ttgattctaa taagatggaa atccctgtct gatttccagc
    10021 gatacggtct gtcatacaac cgtaaaaatg tctgctgatc tgttcatcct gtttcaaaac
    10081 cgctccaatc tcctcaatat atagaacgat ctaagatgct tcacgcaaac ccgataaaaa
    10141 gatagtcata tattacttca ttttattatg tttgtaaaga ccttatttta tttttttctt
    10201 ttcttttagc catgtatcat ttataattgt gcatgaacat tggataatat ctgactgacg
    10261 ctatccaaaa atatttacaa tatgatctgg aggagttcat gaaagagttt gtaattgtaa
    10321 ctgatacaac cactgattta ccaagagaat atgttgaaaa acatcactta tacatgatgt
    10381 cccttcctta caccttagaa ggcacatcct acacctggga aaatccaatg ccggtcaaag
    10441 agttttatga taaaatgcgt gccggatcat taccgaccac ctcacaggcg aatcccgaag
    10501 aagctgctac tttgtatgaa tcgattctga aagaaaatga tgtggatatt ctccatatcg
    10561 cattttcttc cggtctcagc ggaagtttta acagctgcag gatcgccgca gcagacgtat
    10621 gtgaaaaata tccagaccgc cgtatcgtag ttgtggattc acttgccgca acattaggtc
    10681 aggggctctt agtctataaa gcagttcagt taaaggaagc tggaaaaaat ctggatgaaa
    10741 ttgctgcctg gttagaagaa aacaaatatc atctcgtaca taattttacc gtggacgatc
    10801 tttttcatct gcatcgcggc ggacgtctct ctaagacagc tgcaattgta ggtacgatga
    10861 tcaatttaaa accggtactt catgtcgatg atgagggaca tcttgtcatg ttaagcaaag
    10921 tgcgcggccg caagaaatca ctgatcggac tggtcgactg catggaaaaa caactcggtg
    10981 actggaaaga taaaaatgat attatcttta tcagtcatgg tgactgcccg gaagatgcac
    11041 agtttgttgc tgatctgatc aaagaacgtt ttggatatga aaatttcatg attgattata
    11101 tcggtgctac gattggtgca cattccggtc cgggtaccgt tgcactgttt tatatgggag
    11161 atcaccgtta acctctatag cagccatatc ttttacacct tataagtaat ctgttattcc
    11221 aaaagaggca ttttaaaaat gaaaaatcat ttttcaaatg cctcttttcc ttcttcctga
    11281 taccatccct ctcctgctgt gcagatcaaa agctgtccac cgccttttgc tgcgtggtga
    11341 atgtgccagt tattacggca tcccggttca aatgtcacat ttgccataaa tacagcacag
    11401 ttcttcggat ctgtcagtgg attcagataa gaattaccga taaaatactg tgcaaatcct
    11461 gtattctccg cacccgttcc aaatacgttc cgtttttcaa attcttctct acttatagtc
    11521 ttcataattg tattgctcct ttccgttgac ggattctatc atctgcttcc ccatcggaag
    11581 tacttataaa ttctacaact tgaagtgcac tataagtcaa gagctttttg ctagtttgta
    11641 aattttacag ccgtaccata tgcaatgact tctgctgccc cctgcataac tgcagaagat
    11701 gcataacgga tatttacaac cgcatcagca cctaagctct ctgcctcttc caccatgcgc
    11761 tttgttgcaa gtgctctagc ctcattcatc atttcattgt atgcctttaa ctctccgcca
    11821 actaatgttt tgaaactctg tgtaatatct tttccaatat ttttgctctg gatcgtgctt
    11881 ccctttacca gaccaagcat ttctaaattt ttgccgctga tataatcagt atttactaag
    11941 atcatcttct tctccactcc ttatctcctg cacacgttct acggttactg caaatgctac
    12001 tcctgccagt gccagcggaa taattaccat caataatttc atgatgacag tcagatccgg
    12061 gatcagcata aataccgcag caattgcaac ataatacacg atcagaactg ctgcaatgat
    12121 aatcggagcg atcattttgt ttcgatgttc ctttttcata acttttgcct cctttgtgta
    12181 ttatctagtt aatacaataa tacattcaac agaatatgtc aaccacaaat caacgcaaaa
    12241 tatccccagt cccagatgat atgttcaaaa ctgttttcca aatattcgta aatatcatct
    12301 tcctcatatc ccgtcatgcg ggagaccaca accatataat cacgcacatc ttcgtaggaa
    12361 attcctcttc ggcaggaagt tgaaattcct tcttcgcaga agctcccctc cccctgactt
    12421 aacaaccagt gcagaaaaac agcatgcctt attgtggcat attccattgc gatccactgc
    12481 acctgcacga ccatctcctc taaatttcct tccggtttta aagaatctgc atacaactct
    12541 gtcaaaagga accgccgcat caacggctgg tatttcaaaa actgtacttc aaactcccgc
    12601 cattctttta caacttcctc atcgattccc tgttcggata actgttctgc aagctgtgcc
    12661 acaggctcta agtatttttc atacaatcct tccctgcgat aattctctgc aaggtccaaa
    12721 aacagttcgt tgcgctcctc aatggaatac tgcagtgtct gttcaattcc atcaatcgtt
    12781 tctgaaagtt ctaaaaggaa tccacccgga tacatttttg ccatgtctgt caaatccagt
    12841 cccaacgcat cttctgccgc atcttttacc tgcttatttt ccatacaccc atcttttgcc
    12901 tgctcatctt ccacacgctc atatagatca agcagcacat aaaaaatctt catcagatta
    12961 tgctccggcg tatgcgctcc atcctccatc agcttcatta aaaatgctcg caagttcaca
    13021 agcggcgcaa gttcacgata agcagatgta tccatctctc cggaaaatga aatatgttct
    13081 cttttccgca acagatcaat gaccgccgga caagacggca tcagggcgta ttctgtgaca
    13141 tcttcgttaa aggtatggat ctctcttgga aaaagctgac aggtctgtga aagtatctca
    13201 tccccataag taagaaccaa tctgcacaat tttttgccat tcagaaatgg acaatttttc
    13261 tctttattta atccgatgac tctgctgcca tccttctttc ttacataccc actcagcttt
    13321 tctttttttg cctgctgtcc tctatctgta tcatacatcc cgtccggcgt cagagtgtgt
    13381 ttccacttta caaaagtgtc ctcatccacc ccgatcttcc attccctgca gcatgtaaaa
    13441 ctgcaccggt ctgctataca ggtaaaatct tcataataat ccggcttcat ttctctctcc
    13501 tggcttatga ataaatatag ggctgttttt tcaaagggta tttttacctt ttgaaatcca
    13561 gccctacatt ttttataaaa tcttcgtcgt ccactttgag cagtcccaca cggcgttcac
    13621 cacatcctga tagaaatccg gctcatgaca gatcaaaagt actgctccgc ggtattcgtt
    13681 taaagcacgc tttaattcgt cttttgcatc cacatccaga tggttcgtcg gctcgtccag
    13741 aagcaggatg ttagtcgtgc ggttcatcag tttgcacaga cgtactttcg cctgctcacc
    13801 accgctaagt acacgcacct ggctttcgat atgctttgtg gtcagaccgc attttgcaag
    13861 tgctgaacgc acttcgtact gggaaaaagc cggaaattct tcccagattt cttcgataca
    13921 ggtattttta ttttcccctt taatctcctg ctcaaaataa ccgatctcta aattttcccc
    13981 cagagtgact tcccctgata aagccggaac cagtcctaaa atgctgcgca gtaaagtcgt
    14041 ctttccgata ccgtttgcac cgactaaggc gatcttctga ccgcgttcca tagaaatatt
    14101 aagcggcttt gataacggtt catcgtaccc gatgacaaga tcttttgtct caaagatata
    14161 ttttcccggt gtccttccaa gtttgaaatc aaactccggc tttggacgct ctgcggcaag
    14221 ctcgatcaca tccattttat caagtttttt ctgacgggac atcgccatat ttctcgtagc
    14281 aacgcgggcc ttgttgcgcg ccacaaaatc ttttaactca ctgatctcct gctgctgttt
    14341 gcggtatgca gcctcaagct gtgatttttt cactgcataa acttcctgga acttatcgta
    14401 atttcctaca tagcggtcaa gtctctgatt ttccatatga taaatgatat ttaccacatc
    14461 atttaaaaac gggatatcgt gtgagatcag gataaacgca ttctcgtact cctgcagata
    14521 acgcgtcagc catgcaatgt gctctgcatc taaatagttt gtcggctcat ccaaaagaag
    14581 aatgtccggt ttctctaaaa gaagctttgc aagcagcacc ttcatacgct gtccaccgct
    14641 taaatctgaa acatcatggt caagtcccag ttccaataat ccaagtgctc gcgcaacct
//
