LOCUS       c00053_gnlPro..        14430 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|OMKAEKNI_53.
ACCESSION   c00053_gnlPro..
VERSION     c00053_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-05 02:46:24
            Original ID  :: gnl|Prokka|OMKAEKNI_53
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14430
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..921
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) OKR_DC_1_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) OKR_DC_1_7_arginine"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg53_1"
                     /sec_met_domain="OKR_DC_1_C (E-value: 4.7e-13, bitscore:
                     39.4, seeds: 113, tool: rule-based-clusters)"
                     /sec_met_domain="OKR_DC_1_7_arginine (E-value: 1.8e-62,
                     bitscore: 201.1, seeds: 39, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="DLRSIVRVAHEHHMLVLVDEAHGTHLYFGENLPVCAMDAGADMAS
                     VSMHKSGGSLTQSSLLLTGKGVNWEYVSQIINLTQTTSASYLLMSSLDISRRNLALRGK
                     ESFAKVAQMAEYARDEINSIGGFYAYGKDMVNGGSVYDFDVTKLSVYTRDIGLAGIEVY
                     DLLRDEYDIQIELGDIANILAYISIGDRIQDIERLVGALADIKRLYSKDPAKMLNTEYI
                     NPKVLVSPQVAFYSQKESLPVRQTAGRICGEFVMCYPPGIPILAPGEMITPEIIEYIVY
                     AKEKGCSMQGTEDPEVENLNVLAKK"
     protocluster    1..14430
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[988:4430]"
                     /cutoff="10000"
                     /detection_rule="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /neighbourhood="10000"
                     /product="Putrescine2spermidine"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      989..4430
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /neighbourhood="10000"
                     /product="Putrescine2spermidine"
                     /protocluster_number="1"
     cand_cluster    1..14430
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /kind="single"
                     /product="Putrescine2spermidine"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14430
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Putrescine2spermidine"
                     /region_number="1"
                     /rules="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /tool="gutsmash"
     CDS             989..1852
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Spermine_synth"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Spermine_synt_N"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg53_2"
                     /sec_met_domain="Spermine_synth (E-value: 3.5e-52,
                     bitscore: 166.3, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="Spermine_synt_N (E-value: 2.9e-13,
                     bitscore: 39.4, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MELWFSDYHTEKVKVSVKVQKQLFGLQTEFQRIDVFDSDEFGRFL
                     SSDGSIVFSEKDEFVYDEMIVHVPMAVHPHVKKVLVIGGGDGGVARELGYYDEIEQIDV
                     VEPDRVFVEVCKEFFPDNACGLSDERVTVYYEDGLKFLRMKHDEYDLIINDAIDPLGHT
                     AGLFTKEFYGNCFRALKDDGIMVYQHGSPFYDEDEESCRGMHRKASHSFPISRVYQAHI
                     PTCSSGYWLFGFASKKYHPLDDLDAKRWKERKIKTWYYTTNLHKGAFMLPRYVEDMLEE
                     EEGRKK"
     CDS             1950..3209
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Sacchrp_dh_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Sacchrp_dh_NADP"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Epimerase"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg53_3"
                     /sec_met_domain="Sacchrp_dh_C (E-value: 7e-45, bitscore:
                     143.9, seeds: 375, tool: rule-based-clusters)"
                     /sec_met_domain="Sacchrp_dh_NADP (E-value: 2.5e-35,
                     bitscore: 111.4, seeds: 81, tool: rule-based-clusters)"
                     /sec_met_domain="Epimerase (E-value: 1.1e-07, bitscore:
                     21.3, seeds: 96, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGRLLIIGCGGVAGVAIHKCCQNSKTFTEICIASRTKSKCDALKE
                     KLEKTTDTVITTAQVDADNTEELIALIKKYQPDAVLNVALPYQDLTIMDACLACKVDYI
                     DTANYEPEDTDDKEWRAIYEKRCKEEGFTAYFDYSWQWAYREKFKEAGITALLGSGFDP
                     GVTSVFTAYALKHYFDEIETIDILDCNGGDHGYPFATNFNPEINLREVSANGSYWENGH
                     WVETKPMEIKREYNFPQVGEKDMYLLHHEEIESLAKNVPGVKRIRFFMTFGQSYLTHMK
                     CLENVGMLSTSPIEYEGREIVPIQFLKALLPDPASLGPRTVGKTNIGCIFTGKKDGKEK
                     TIYIYNVCDHQECYKEVGSQAISYTTGVPAMIGAALVVDKVWDKDGVFNIEEFDPDPFM
                     DMLNQYGLPWVVDENPQTVA"
     CDS             3297..4430
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Orn_DAP_Arg_deC"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg53_4"
                     /sec_met_domain="Orn_DAP_Arg_deC (E-value: 3.7e-14,
                     bitscore: 42.7, seeds: 500, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKWQEIPTPCYVVDEKKLKQNLKILQNLEQETGCHVLLAQKAFSM
                     FSLYPLIGQYISGTTASGIFEARLGKEEMGKENHVFAPAYKEKDMEELVQICDHVIFNS
                     FAQYEKYQHYFLQQECTASAGIRVNPECSTQEGHEIYDPCGPGSRLGVVKSEFPDQLPE
                     GIEGLHFHTLCEQNADDLITTWHAFEEKFGSYLKQVKWLNLGGGHHITRADYQLDELKK
                     LICEIRRKYNVRVYLEPGEAIALNAGYLVTEVMDIVHNGMDILILDASAACHMPDVLEM
                     PYRPPLKDGYLPGEKPHTCRLSSMTCLAGDVIGDYSFAQKKQVGDRLVFEDMAIYSMVK
                     NNTFNGMPLPGIAVLREDGDVEMIKEFGYEDFKGRLS"
     CDS             4402..5625
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PAD_porph"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg53_5"
                     /sec_met_domain="PAD_porph (E-value: 4.7e-117, bitscore:
                     380.5, seeds: 436, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKISKADCPEMIKDTTPVQDGFFMPGEFEQHQGCIMIWPERPGSW
                     RNGAKEAETAFSAVIRAIAASETVYVAAGKKGIDHAKAFAESLKKEENLHPVVVFEMET
                     DDSWARDVAPTFLVNRTDGKISDLTAAGNGTAQTGDDVKNSQVRGVNWSFNAWGGEVDG
                     LYASYEKDNAFAWNFCRKFEFDCYDAEPFVLEGGSIHSDGEGTLLVTEPCLLSAGRNPS
                     LTKEQIEEQLKCYLGVEKVLWLPRGIYQDETNEHVDNVCAFLRPGEVVLAWTDNQNDPQ
                     YAMSKASFDYLSSVRDAKARKLIIHKLPIPDIPVCITKEELEGYEFEEGEDVREVGERL
                     AASYVNFYFSNNAVVMPVFGGENEESDLRAQQIMAKLCPDRKIIPVYARDILTGGGNIH
                     CITQQIPL"
     CDS             5703..6593
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) CN_hydrolase"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg53_6"
                     /sec_met_domain="CN_hydrolase (E-value: 1.1e-53, bitscore:
                     172.0, seeds: 52, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRQIKAAAIQMKCDLEHKKNLQKAEQMIRKAAAEGANIILLPELF
                     EREYFCQQRRYDFYSYARTVEESEAVAMGVRLAKELGVVLPISFYERDVNNLYNSIACI
                     DGDGTILGVYRKTHIPDDHYYQEKFYFTPGDTGFKVFDTKYGCIGIGICWDQWFPETAR
                     AMALLGAELLFYPTAIGSEPILECDSMPHWRRCMQGHAAANLMPVIAANRIGREVVQPC
                     AENGGQESALEFYGSSFLTDETGEVILSASRDKEEILSQTYELDELRAKRLEWGLFRDR
                     RPEYYGIIAGEKNGR"
     CDS             complement(6822..7832)
                     /locus_tag="ctg53_7"
                     /transl_table=11
                     /translation="MEHLIIPKDYHSELNLHDTQIAIKTVKDFFQNLLALRLNLSRVSA
                     PLFVDPLSGLNDNLNGIERPVTFDIKEQNGKEAEVVQSLAKWKRYALKKYGFDYGEGLY
                     TDMNAIRRDEDTDNIHSIFVDQWDWEKIIHKEDRNIETLKETVNTVYNCLRKTEKYMAI
                     QYDYIEEILPHDIFFITTQELEEMFPDNTPKEREYYITKTKGAVCIMKIGDTLENGEPH
                     DGRAPDYDDWSLNADIVVYYPVLDIALEISSMGIRVDKKALLSQLKKAGCEERAKLPFQ
                     KAIINEELPYTIGGGIGQSRICMFFLRKAHIGEVQSSLWPEAIAKECEKNGIQLL"
     CDS             8100..10082
                     /locus_tag="ctg53_8"
                     /transl_table=11
                     /translation="MKKQKTVSIKAKLLGVIIPVVIAIVVVLVVAAYQISAGTIKKYSQ
                     NLLQSSVENQASQIEAWLNENLASFQMAKTTIEDLKPSDEELKTILDGYYGYNSNYPEG
                     LYVADSTGQLITASESTKKESDVTNSIWYKEGLTRVNMAVGSAYQNADGVNVISASGIL
                     NDGSDKVRVISADMTLDRIAIIVNSFIEMNDAEAFLVDKTSGVILANRDSSLISQTLGA
                     EGQSHFYQLTAEKVADKDYNFVTLDGNMTVFQEVEGTNWLLVSYIPTSTVLADLTQLRN
                     IMIVISVICIALLCVLIERVTHVVIKPVKEMTRVITAMTSGDFTVSIKTKGNDEIAVMS
                     QSVEKFIDSMKQMISEMGSVSGKLKNQADSSKGVSSEMSSAAGIQSQSMSELNATVDQL
                     SVSVNEIAENATQLAGVAADTKSDSDMVESKMQETVAVSEKGRKDMERVGEALSNIEVS
                     IHNLEEAVNKVGTASGEIVQIIKLIGDIADETNLLSLNASIEAARAGEAGRGFAVVATE
                     IGTLAKNSADSVAHITELITEINNLVEDAVRQAGNSAQDISGSAELIHTAVDTFDTIFK
                     NIQETSALIGNVVDKINQVDQVATNVAAISEEQAASSDEILATSESMLQQAKNISKNSD
                     QVEQEADNLAVSADQLADQVKQFRI"
     CDS             10098..11072
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peripla_BP_1"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg53_9"
                     /sec_met_domain="Peripla_BP_1 (E-value: 7.4e-13, bitscore:
                     38.3, seeds: 6, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKLISTIMCLALLVGCLAGCGGNTQTGAADGKGLKMLLSLSQAD
                     TFRNVLVAQAQQTAEECGVQLDVLDADNSIENQVEHIKKAVSENYDVILCGPVDADTAF
                     ELEALAGDIPIVFFNSCPDESRLQAGKYIYVGSDEYVAGQYQAEYILDKFASADEINVV
                     LLKGPKKHSATKGRSESLKDTLNASGKKINYVFEDNADWEQDRAKEMFNIFLKTGQKCD
                     VAVCNNDSMALGIIDACDAAGISDVTVLGIDATADGCKAIEDGKMDFTVYQSAVGQGES
                     AVYAAIALATGKDVTTLEGATEDGLYVWVPFEKVDSSNVKNYE"
     CDS             11087..11596
                     /locus_tag="ctg53_10"
                     /transl_table=11
                     /translation="MEYTHVKHTFLPVYNEESRILILGSFPSVKSRENQFYYGHPQNRF
                     WKVIAGIFKEPLPQTIDEKKDLLLRHRIAVWDVIDSCDIVGSSDSSIRNVVPNDMNLIL
                     SNAKIQGIFANGGKAHQLFVKYCHKEGMPPLGKLPSTSPANAAWNLERLTAEWKTAFGM
                     YLEITE"
     CDS             11554..12054
                     /locus_tag="ctg53_11"
                     /transl_table=11
                     /translation="MENGIWNVFRNNRIEDEEQHRKGINLKKEEMTNMDFLLEAVGIVA
                     AMIYLGLQIYYGIVYGVAFTGIILNAAILILVYVGLTLLARYPERVNNLPKEICSGKIR
                     KYTIHMVRAVKLIFVLSLLFTSICDVAGVQINKGYSLVTVALIAVVTVVYEGKIIKLLR
                     GKK"
     CDS             complement(12150..12353)
                     /locus_tag="ctg53_12"
                     /transl_table=11
                     /translation="VKFQRIQDLRIDNDLTIKEISAMLGLHRDVYSRYEKGLRDFPIDI
                     LIKLADIYHCSIDYLVGRVDTK"
ORIGIN
        1 gatctgcggt ctatcgtgag agtggcgcat gaacatcata tgctggtgct ggtggatgag
       61 gcacacggaa cgcatctgta ttttggggaa aatcttccgg tatgtgccat ggatgccggg
      121 gcggatatgg cgtctgtctc catgcacaag tcggggggaa gcctgacgca gagctctctt
      181 cttctgaccg gaaagggtgt gaactgggaa tatgtcagcc agatcatcaa tctgacgcag
      241 acgacgagtg catcttatct tctgatgtcg agccttgata tttcgcggag aaaccttgcc
      301 ttgcgaggga aggaatcttt tgcgaaagtg gcacagatgg cggagtacgc gagggatgag
      361 atcaattcta tcggtggatt ttatgcgtat ggcaaagata tggtaaacgg tggcagtgtc
      421 tatgattttg atgtgacaaa actgtctgta tatacgagag atatcgggct tgcaggcatt
      481 gaggtttatg atctgctgcg ggatgaatat gatattcaga tcgagcttgg agatatcgca
      541 aatattcttg cctatatttc catcggtgac cggatacagg acattgagcg gcttgtgggt
      601 gcacttgcag acatcaaacg gctgtattcg aaagatccgg caaaaatgct gaatacggaa
      661 tatattaatc cgaaggtttt agtgtcgccg caggtggcat tttattcgca aaaggaatcc
      721 ctgccggttc gtcagacagc gggaaggatc tgcggtgaat ttgtcatgtg ctatccgcct
      781 ggaattccga ttttagcgcc gggtgagatg atcacgccgg agatcattga gtacattgtt
      841 tatgcaaaag aaaagggatg ctctatgcag ggaacggagg atccggaagt tgaaaatctg
      901 aatgtgcttg caaagaaata acagcataga tcagcaaaaa taaagattcc tgtgaaaaga
      961 agattttttc aaaagaaggg agaagatcat ggaactttgg ttttcggatt atcacacgga
     1021 aaaagtcaag gtgtcggtca aggtgcagaa acagttattt ggtttacaga ccgagtttca
     1081 gcggatcgat gtgtttgatt cggatgagtt tgggcgtttt ttaagttccg acggtagtat
     1141 tgttttttcg gaaaaagatg agtttgtcta tgatgagatg attgtgcatg ttccgatggc
     1201 ggtgcatccg catgtgaaaa aggtgttagt catcggcggc ggtgacggcg gcgtggcacg
     1261 ggagcttggc tattacgatg agatagagca gatcgatgtc gtggagccgg atcgtgtatt
     1321 tgtcgaggtc tgcaaggaat tttttccgga caatgcatgc gggttatcgg atgaacgcgt
     1381 gacggtgtac tatgaggatg gattgaaatt tttgcggatg aaacatgacg agtatgatct
     1441 gatcatcaac gatgcgattg atccgcttgg acatactgca ggactgttta ccaaggaatt
     1501 ttacggaaac tgcttccgtg ccttaaaaga tgacggaatc atggtatatc agcatggaag
     1561 tccgttttac gatgaagatg aggaatcctg ccgcggtatg caccggaaag cgagtcatag
     1621 ctttccaatc agccgcgtgt atcaggcaca tataccaacg tgttcttccg gatactggct
     1681 gttcgggttt gcgtcaaaga aatatcatcc gctcgatgat ctggatgcaa agcgctggaa
     1741 agagcggaag ataaaaacct ggtattatac caccaatctg cacaagggag catttatgct
     1801 gccgcgatat gtggaggata tgttagagga agaagaagga cgtaagaaat aataaaaatt
     1861 aaattaaaat ttattttttt acacgcaaga tttgtgcccc ggcacaaact tgagatgcgc
     1921 aaaaagacag cgcaggaaag gagattaaaa tgggaagatt attaattatc ggatgtggcg
     1981 gagttgcagg agttgcgatt cacaaatgct gccagaacag caaaactttt acggagatct
     2041 gcattgcgag cagaacaaaa tcgaaatgtg acgccttaaa agagaaactg gaaaaaacaa
     2101 cggacactgt catcacaaca gcacaggtgg atgcggacaa tacggaggaa ctgatcgccc
     2161 tgatcaaaaa atatcagccg gatgctgtgt taaatgttgc tttgccatat caggatttaa
     2221 caattatgga tgcctgcctt gcatgcaaag tagactatat cgataccgca aattatgagc
     2281 cggaggatac ggatgacaaa gaatggcgtg ccatctatga aaaacgctgt aaagaagagg
     2341 gatttacagc atattttgac tattcctggc agtgggcata ccgtgaaaaa ttcaaagagg
     2401 caggaattac ggcattgctt ggaagcgggt ttgatccggg agtgaccagt gtatttaccg
     2461 cttatgccct gaaacattat ttcgatgaga tcgagacgat tgatatctta gactgtaacg
     2521 gcggcgacca cggctatccg tttgcaacca attttaaccc ggagatcaac ctgcgtgagg
     2581 tttccgcaaa cggttcttac tgggagaatg gtcactgggt agaaacaaaa ccaatggaaa
     2641 ttaaaagaga atataatttc ccacaggttg gcgagaaaga tatgtatctg ctgcatcatg
     2701 aggaaattga gtcccttgca aaaaatgtac ctggagtaaa gcggatccgt ttctttatga
     2761 cctttggaca gagctatctg acacatatga aatgtttaga aaatgtcgga atgctctcaa
     2821 catcaccgat cgagtatgag ggcagggaga tcgtaccaat ccagttctta aaagcactgc
     2881 ttccggatcc ggcatcttta ggaccgcgca cggttggaaa aacaaatatc ggctgtatct
     2941 ttacgggaaa aaaagacgga aaagaaaaga cgatttatat ctataatgtc tgtgaccatc
     3001 aggaatgtta caaagaagtc ggttcccagg caatttctta tacaacaggt gttccggcta
     3061 tgatcggtgc agcgttagtt gtcgataaag tctgggacaa agacggtgta ttcaatattg
     3121 aagagtttga tccggatccg tttatggata tgttaaacca gtatggtctg ccatgggttg
     3181 tggacgaaaa tccgcagacg gtggcataaa ataagaatat gtgtgaaacg ggttggataa
     3241 aattttaaat ttgtcagctt ttgcgcagcg gatttttgca gaaatggaga attatcatga
     3301 aatggcagga gattcctacc ccgtgttatg tggtagatga aaagaagcta aaacaaaatt
     3361 taaaaatatt gcagaatttg gaacaggaaa ccggctgcca tgtgcttctg gcacagaagg
     3421 cattttccat gttttcactg tatccgctga tcgggcagta tatcagcgga acgacggcga
     3481 gcggaatctt tgaggcgcgc cttggaaaag aggagatggg aaaggaaaat catgtatttg
     3541 caccggctta taaggaaaaa gatatggaag aactggtgca gatctgcgat cacgttattt
     3601 ttaattcctt tgcgcagtat gaaaagtatc agcactattt tttgcagcag gagtgcactg
     3661 caagtgccgg gatccgcgtg aacccggagt gctccacaca ggaagggcat gagatctatg
     3721 atccatgcgg accgggatca aggcttggtg tggttaaaag tgaatttccg gatcaactgc
     3781 cggagggaat cgaaggatta cattttcata cactctgcga gcagaatgcg gatgatctga
     3841 tcacgacctg gcatgcgttt gaggagaagt ttggcagtta tttaaaacag gtaaaatggc
     3901 tgaacttagg cggcggtcat catattacaa gagcagacta tcagttggat gaactaaaga
     3961 agttaatctg tgagatcagg cgaaaatata atgtccgggt ctacctggaa ccgggtgagg
     4021 cgatcgcatt aaatgcgggc tatcttgtca cggaggttat ggatatcgta cacaatggaa
     4081 tggatatcct gattctggat gcatcggcgg catgccacat gccggatgtg cttgaaatgc
     4141 catatagacc gccgctaaaa gacggttatc tgccgggcga aaagccgcat acctgccggc
     4201 tttcttccat gacctgcctt gccggggatg tgatcggtga ttacagcttt gcacagaaaa
     4261 aacaggtggg agaccgtctg gtctttgagg atatggcaat ttattccatg gtcaaaaaca
     4321 atacatttaa cgggatgccg ctgcccggaa ttgcagtctt acgggaagat ggagatgtcg
     4381 agatgataaa ggagtttggt tatgaagatt tcaaaggcag actgtcctga gatgataaaa
     4441 gatacaacac cggtacagga cggatttttc atgccgggtg agtttgagca gcatcaggga
     4501 tgtatcatga tctggccgga gcgtcccggt tcctggagaa atggcgcgaa ggaagcagaa
     4561 acagcgtttt cagctgtgat ccgtgcaatc gccgcgagtg agacagtgta tgtcgctgcc
     4621 ggaaaaaagg ggattgacca tgcaaaagca tttgcggaaa gtctgaaaaa agaagaaaac
     4681 ttacatccgg tggttgtctt tgagatggag accgatgatt cctgggcgcg ggatgttgcg
     4741 ccgacctttc tggtaaacag aacggatgga aagatttcag acctgacagc agcaggaaat
     4801 ggtacggcgc agacaggtga tgatgtaaaa aactcacagg tgcgcggtgt aaactggtct
     4861 tttaatgcct ggggcggtga agtggatgga ctatatgctt cttatgaaaa agacaatgcg
     4921 tttgcatgga atttctgcag aaaattcgag tttgactgtt atgatgccga accgtttgtg
     4981 ttagagggcg gttctatcca cagcgacgga gagggaacat tgcttgtcac ggagccctgt
     5041 ctgctcagcg cggggagaaa cccatcgctt acaaaggagc agattgaaga acagttaaag
     5101 tgttaccttg gcgtggagaa agttttatgg ctgccacgcg ggatctatca ggatgagacc
     5161 aacgagcatg tggacaatgt ctgtgcattt ctaagaccgg gtgaagttgt gcttgcatgg
     5221 accgataatc agaatgatcc gcagtatgcg atgtcgaaag cgagttttga ttatctaagt
     5281 tcggtgcggg acgcaaaggc cagaaagctg atcatccaca aacttccaat tccggatatt
     5341 ccggtctgta tcaccaaaga agaactcgaa ggatacgaat ttgaggaagg tgaagatgtc
     5401 agggaagtcg gagaacggct cgccgcctcc tatgtaaact tttatttttc caacaatgcg
     5461 gtagtcatgc ctgtatttgg cggagaaaac gaagaaagcg acctgcgtgc acagcagatt
     5521 atggcaaaac tctgcccgga cagaaaaatc ataccggtgt acgcaagaga catactgaca
     5581 ggcggtggaa acatccactg tattacacag caaattccct tatagggaat ttattgtaca
     5641 accttccata taggagaatt aattcactgt gcaaaaataa aaagaacaga aaggatacac
     5701 gcatgagaca gataaaagca gccgcaattc agatgaaatg cgacctggag cacaagaaaa
     5761 acttacaaaa ggcagaacaa atgatccgca aagctgccgc ggaaggcgca aatatcattt
     5821 tactgccgga actttttgag cgggaatatt tctgccagca gcgcagatat gatttttaca
     5881 gctatgcaag aactgtggag gagagtgaag ctgtggcaat gggagtacgt cttgcaaaag
     5941 aattgggcgt ggtgcttcca atcagctttt atgagcgtga tgtcaataac ctctataatt
     6001 cgatcgcatg cattgatgga gatggaacga tcctcggtgt gtatcggaaa acccacatcc
     6061 cggatgatca ttattatcag gaaaaatttt attttacacc gggagatacc ggatttaaag
     6121 tgtttgatac aaaatacggt tgcatcggta ttggaatctg ctgggatcag tggttcccgg
     6181 agacagcgcg cgcgatggcg ctgctcggtg cagaattatt gttttacccg acagcgatcg
     6241 gctcggaacc gattttagaa tgtgacagta tgccgcactg gagacgctgc atgcagggac
     6301 atgcggctgc aaatctgatg cctgtcattg ccgcaaaccg gatcggcagg gaagtagtgc
     6361 agccatgtgc ggaaaatggc ggacaggagt cggcactgga attttatggt tcctcatttc
     6421 tgacggatga aacaggagag gtgatcttaa gcgcttccag agataaagaa gaaatcctga
     6481 gccagaccta tgaactggat gaacttcggg caaaacgact ggaatgggga cttttccggg
     6541 acagaagacc ggaatattac ggaatcatag caggagaaaa aaacgggaga tagtgagaac
     6601 cagacgggat tgaaaagacc ggaagattgt ggaaatcaca cgggactgaa aagaacggaa
     6661 gatagtggaa accgcacagg actgaaaaaa cagaaagatg aaaaaaacag gtatgttttt
     6721 gtcagcaggg aaagctcatt gctgacattt gaaacatacc tgttttttat caggcatcag
     6781 tgttgatgac aggatatctg cggagcatat gcccgttcct gttacaaaag ctgaataccg
     6841 ttcttttcac attcttttgc gatagcttcc ggccacaggg aagactgtac ctctccaata
     6901 tgtgccttgc gaaggaagaa catacagata cgggactgtc cgattccacc accaattgta
     6961 taaggaagct cttcgttgat gattgctttc tggaaaggaa gttttgcacg ttcttcacag
     7021 cctgcttttt tgagctggga gagaagcgct ttcttgtcaa cccggatacc catggaggaa
     7081 atctcaagtg cgatgtcgag taccggatag taaacaacga tatctgcgtt taaagaccag
     7141 tcatcgtaat ccggagcacg tccgtcgtga ggctctccgt tttccaaagt atcgccgatc
     7201 ttcatgatac atacggcacc cttggttttt gtaatataat attcacgttc ctttggtgtg
     7261 ttgtcaggga acatttcttc caattcctga gtcgtgataa agaagatatc atgtggaaga
     7321 atctcttcta tataatcgta ctggatcgcc atatattttt ctgtcttgcg caggcagtta
     7381 taaacagtgt taactgtttc ttttaatgtc tcgatatttc gatcctcttt atggatgatt
     7441 ttttcccagt cccactggtc tacaaagata gagtggatgt tatccgtgtc ttcatctctg
     7501 cggatcgcat tcatatcggt atacagacct tcaccgtagt cgaaaccgta tttctttaaa
     7561 gcgtagcgtt tccattttgc gagagactgt acaacttctg cctctttccc gttctgctct
     7621 ttgatatcga aagtaaccgg acgttcaata ccgtttaagt tgtcattgag accggataac
     7681 ggatcaacaa aaagcggtgc tgaaacgcgg gacagattca gacgaagtgc aagcaggttc
     7741 tggaaaaaat cttttactgt tttgattgca atctgtgtat cgtgcagatt taattctgaa
     7801 tgataatctt ttggaatgat taaatgttcc atctaaggtt ctcctctctg gtataaaccg
     7861 catgcagcgg catgatacca atcccgtgtg cctgatatat gtatgaaaaa gaaaatggca
     7921 cactaattta ttatagcaca gcaggtctca ttttcaagaa aagatcatac gatttcttga
     7981 aaaatacatg tatacaatat aaattttagc gaaaacggtt tgtgatacat attgacgaaa
     8041 aacgacgatg actttataat ttatgttgta aattttatgt aaaaaagaga ggacagctta
     8101 tgaaaaaaca aaaaacggtg tcgattaagg caaagttact tggtgtgatc ataccagtcg
     8161 taattgcgat cgttgtggta cttgttgtgg ctgcttatca gatatctgca gggacgatca
     8221 aaaaatattc ccagaattta ctgcagtctt cggtagagaa ccaggcatcc cagatagaag
     8281 catggctgaa tgaaaacctt gcttcatttc agatggcgaa gacaaccatt gaggatttga
     8341 agccgagtga tgaagagtta aagacaatac tggatggtta ttatggctat aacagtaatt
     8401 atccggaggg actttatgtg gcagattcca caggacagct cataacggca tcagaatcaa
     8461 caaaaaagga atcagatgta acaaacagta tctggtataa agaaggactt accagggtga
     8521 atatggcagt cggttcggct taccagaatg cagatggcgt gaatgtgatc agtgcctccg
     8581 gtattttaaa tgacggatct gataaagtgc gtgttatttc agcagatatg acattagacc
     8641 gtattgcaat tatcgtaaac tcttttattg aaatgaatga tgcggaagca tttctggttg
     8701 ataaaaccag cggtgtgatc ctggcaaacc gtgattcatc tcttatttct cagacgcttg
     8761 gcgcagaggg acagagtcat ttttaccagc ttacagcaga aaaagttgcg gataaagatt
     8821 ataattttgt aacactcgat ggaaatatga cggtatttca ggaggtagaa ggaacaaact
     8881 ggcttctggt atcgtatatt cctaccagca cagtattagc ggatctgaca cagcttcgca
     8941 atattatgat cgtgatcagt gtgatctgta ttgcattgct ctgtgtactg atcgaacgtg
     9001 taactcatgt tgtaatcaaa cctgtcaagg aaatgacaag agtgatcaca gcgatgactt
     9061 ccggtgattt cacggtttct attaagacaa aaggcaatga tgagattgca gtcatgagcc
     9121 aaagtgtgga gaagtttatt gattccatga aacagatgat ctccgagatg ggaagtgttt
     9181 ccggcaagtt gaagaatcag gctgactcaa gtaagggtgt ttccagtgag atgagttcgg
     9241 cagcgggaat ccagtcacag tccatgagtg agttgaacgc gacggttgat cagttgtctg
     9301 tatctgtaaa tgagatcgcg gaaaatgcaa cgcagcttgc aggtgtggca gcagatacca
     9361 agagcgacag tgatatggtt gaaagcaaga tgcaggagac ggttgctgtt tctgaaaaag
     9421 gacgtaagga tatggagcgc gttggtgagg cactctcaaa tatcgaagtt tccattcaca
     9481 atctggaaga ggctgttaat aaggtaggaa ccgcttcagg cgagattgtg cagatcatca
     9541 aactgattgg tgatattgct gacgagacga acctgttatc tttaaatgct tcgattgagg
     9601 ctgcacgcgc aggcgaagca ggaagagggt ttgcagttgt tgcaactgag attggtacac
     9661 ttgcaaagaa cagtgcggat tcggtagcac atatcacaga gctgatcact gagatcaaca
     9721 atctggtaga agatgccgtc agacaggcag gaaacagtgc acaggatatt tccggcagtg
     9781 cagagctgat ccatacagca gttgatacat ttgatacgat ctttaagaat atccaggaga
     9841 caagcgcact gatcggcaat gtggttgata agatcaatca ggtagatcag gttgctacga
     9901 atgttgcagc tatttcggaa gagcaggcgg caagttccga tgagatcctt gcaacatcag
     9961 aatccatgtt acagcaggca aagaatattt caaagaacag tgaccaggta gaacaggaag
    10021 cagataacct tgctgtttct gcagatcagc ttgcagatca ggtaaaacag ttccggatat
    10081 agagaggaga tcgtgcgatg aagaaattaa taagtactat catgtgtctg gcattgctcg
    10141 taggatgcct tgccggatgt ggtggaaata cacagacagg cgcagctgat ggaaaaggtt
    10201 taaaaatgct gctgtcgtta tcacaggcgg ataccttccg aaatgtactt gtggcgcagg
    10261 cgcagcagac tgcggaagag tgtggggtac agttggatgt gctagatgcg gacaattcca
    10321 ttgaaaatca ggtggagcat atcaaaaagg cggtcagtga gaattatgat gtgattttat
    10381 gcggaccggt tgatgctgat acggcattcg aattagaagc gcttgcaggt gatataccaa
    10441 tcgtattttt taacagctgc ccggatgagt cgagacttca ggctgggaaa tatatttatg
    10501 ttggatcgga tgaatatgtg gcaggacagt atcaggcaga gtatattcta gataaatttg
    10561 cttctgcgga tgagattaat gtggtgttgt taaaaggacc gaaaaaacat tccgcgacaa
    10621 aaggaagatc tgagtcatta aaggatactt taaatgcatc agggaaaaag atcaattatg
    10681 tctttgaaga taacgccgac tgggagcagg atcgtgcgaa agagatgttc aatatatttt
    10741 taaagacagg acagaagtgt gacgttgctg tctgcaacaa cgactctatg gcacttggta
    10801 tcattgatgc ctgtgatgca gcaggaatca gtgatgtgac ggtacttgga atcgatgcaa
    10861 ctgcagacgg atgcaaagcg attgaagatg gaaagatgga ctttaccgta taccagtccg
    10921 cagttggaca gggtgagagt gctgtctatg cagcaatcgc acttgcaacc ggaaaagatg
    10981 tcacgacctt agagggtgct acggaagatg gtttatatgt ctgggtacca tttgaaaaag
    11041 tagacagctc caatgtcaaa aattatgaat agaaagcggg tataaaatgg aatatacaca
    11101 tgtaaaacat acgtttttac ctgtatacaa tgaggaatcc aggatattga tcctgggttc
    11161 ctttccgtct gtaaagtcgc gggaaaacca gttctattac gggcatccgc aaaaccggtt
    11221 ctggaaggtg attgcaggga ttttcaagga acctctgcca cagacgatcg atgaaaagaa
    11281 ggatcttctg ctaagacatc gcatagcagt gtgggatgtg atcgattcct gtgatatcgt
    11341 tggatcttcc gacagctcta tcagaaatgt ggtgccaaat gatatgaatc tgatcttatc
    11401 aaatgcaaaa atacagggaa tttttgcaaa tggtggaaaa gcacatcagc tttttgtaaa
    11461 atactgtcat aaagagggaa tgccgccgct tggaaaactg ccgtccacaa gccccgcaaa
    11521 tgcggcgtgg aatttagagc ggctgacggc ggaatggaaa acggcatttg gaatgtattt
    11581 agaaataaca gaatagaaga tgaagaacag cacaggaagg ggataaattt gaaaaaagaa
    11641 gaaatgacaa atatggattt cctgcttgag gcagtgggaa tcgtagctgc aatgatttat
    11701 ctgggactgc agatttatta tggaatcgta tatggagtgg catttaccgg aattatttta
    11761 aatgcggcaa tcctgatcct tgtatatgtt ggactgacgc tgcttgcacg ttatccggaa
    11821 agggtaaata acctgccgaa agaaatatgt agtgggaaaa taagaaaata tacgattcat
    11881 atggtgcgcg cagtcaagct gatcttcgtg ctcagtcttt tatttaccag tatctgtgat
    11941 gtcgccggag tgcagatcaa taagggatac agtctggtga cggtggcgct gattgctgtg
    12001 gtgacggtgg tgtatgaggg gaagatcatt aagctgctgc gtgggaaaaa ataagcatat
    12061 attataaaga aaagacgatt ctgagtggaa tcgtcttttc tttatatata gtgatcaatg
    12121 tctgcggagt aggcattttg tgtattatat tacttcgtat caacccgtcc aaccagataa
    12181 tcaattgagc aatgataaat atctgctaac tttatgagaa tgtcaattgg aaaatcacga
    12241 agcccttttt cataacggga ataaacatcc cggtgcagac caagcatggc agagatttct
    12301 tttatagtaa gatcgttgtc tattctcaag tcctgaattc tttgaaactt cacgtgagtg
    12361 tctcctctaa cttaatagac aaattataat caaaatgcta taatttaatt cataataaga
    12421 ccgtttagtc gtattaagag aaatgagata tctacgaaag gagaccagtt atgaaaaaac
    12481 gtatgatagc atggctgctt tgtgcctgca tgacgtttac ggcagcaccg gaaatgctgc
    12541 tggcggatgt ggcagggaat gcacagcaga cacaggaaga aaacagtttc aaagagaaag
    12601 ggactgtgga aacacagact gtagaacagg atgatgaaaa gtcagcagtg acagagaaaa
    12661 aagaaacaga ccaggcagat gaagaagatc ataatgccgg acgtctggca gaggaagagt
    12721 ccggggcggc cgggacggaa attgtcacgg aagagacaga agagccagag acgacgatcg
    12781 tcacggaaga gacagaagag ccagaaacga aggttgttac agaagaaaca gaggagactg
    12841 aaacaaagaa tgtcacagaa gagccagaac aggctgaaac agagaacgtt acggaagaaa
    12901 cggagagtac agaggagatt ttaaaaaggg cattatcagg tgatgagatc agccgtatcg
    12961 actgggtaca ggaactggta acattatttg atcttacggt agatgaggat aattatccgg
    13021 ataattatta cagtgacata tcaacggatg attcgtttta tcgtgatgtg atggtggcat
    13081 gcgagttcgg aatgatcgat cttgaggcag gagaagaatt tcgaccggaa gatgcagtga
    13141 cgcgtgaatt tgcagcgcag accatgaata cgatgcttgg ctttgtgccg gaaacagaca
    13201 gttatactta tcaggataca gcagatgtta catataagga agcagcacag atcgcaatcg
    13261 acagaggatg ggttacggtt gctgccggta aatttctccc ggaacagtca cttaccacgg
    13321 aagagcatga tgcaatgatc gcggatgcaa aaaaggtttt ggcagatgcg cagatagaga
    13381 ccggaaaaga aaatacctgt acatttgcgt ccggagtagt tgttgtacca aagggaacag
    13441 ccgtatctat tgatgtggat ggaatagtta tgatcgaaaa ctgtccggtt acgatcaaac
    13501 agggaacaac atttgccgtg tatgttaacg atattgtcat ggcatataag gcagaaagtg
    13561 tacggacaga cggaactaca acatatatta caacctcaga tgcggatgat ggcgcggttt
    13621 taaatgttga ccagcagggc gaactggatg ttgatatgac ggaatttatt ccggcagatg
    13681 aagaaacata tgtggtaaat ggtgttacag tcacagaagg tatgacaagg gggatatcct
    13741 ataaaaacaa taccctgcgt gcagataaaa cgatttccgt ctcagatgat gtcacagcga
    13801 cagtaagtgt tgtgatttca aacatgaaag taaattacag tctgaataat aatgactatt
    13861 atttttcagt cagcggagat atggaatact cctgcaatgt aaaaggggat gcatttaaag
    13921 atattaacca cacactgacg ttaggggcag tgccgctcgg cggtgttggt atgttgacac
    13981 tggcaatgga atataatctt tccggggaag caacgcttac cgtggaaaag gaatttgaag
    14041 ccggatttgc gtattcggac ggattccgta tagttggaaa cagtcataaa aaaggatttt
    14101 ccttttcagc agaagcagat ctgaccacag gtattgtact ctctgcaaaa gcaacgctcg
    14161 gaattgtcag cggagatatt tatgcaaaaa ccggtgcacg tatgaacatc aaatacgtaa
    14221 ggtacagttc cggaacaccg acatactgcg cgtcacaggc tgcatatctg tatgcatcgg
    14281 tgggggcaag tgcaaagatc ggagttggta ttgcatcaaa gacctttagc aaaagtatag
    14341 agatctgggg aaagaataac agtccggtgc gcgtgtacta tcatattgag gacggtgtac
    14401 ttcggacatc atgcacgcgt ggaaaagaat
//
