LOCUS       c00075_gnlPro..        12689 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|OMKAEKNI_75.
ACCESSION   c00075_gnlPro..
VERSION     c00075_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-05 02:46:24
            Original ID  :: gnl|Prokka|OMKAEKNI_75
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 12689
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12689
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[8175:12687]"
                     /cutoff="10000"
                     /detection_rule="(not (POR or POR_N or PFOR_II) and
                     minimum(4, [Acyl-CoA_dh_1, Acyl-CoA_dh_2, ECH_2, ETF,
                     ETF_alpha, HCDH_N, Thiolase_N, ketoacyl-synt]) and HCDH and
                     minimum(1, [EC1_2-faecali, ECH1_Enoyl_CoA_DH1,
                     ECH1_Enoyl_CoA_DH2, ECH1_Enoyl_CoA_DH3, ECH1_Enoyl_CoA_DH4,
                     Thiolase_C]))"
                     /neighbourhood="10000"
                     /product="acetate2butyrate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      8176..12687
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(not (POR or POR_N or PFOR_II) and
                     minimum(4, [Acyl-CoA_dh_1, Acyl-CoA_dh_2, ECH_2, ETF,
                     ETF_alpha, HCDH_N, Thiolase_N, ketoacyl-synt]) and HCDH and
                     minimum(1, [EC1_2-faecali, ECH1_Enoyl_CoA_DH1,
                     ECH1_Enoyl_CoA_DH2, ECH1_Enoyl_CoA_DH3, ECH1_Enoyl_CoA_DH4,
                     Thiolase_C]))"
                     /neighbourhood="10000"
                     /product="acetate2butyrate"
                     /protocluster_number="1"
     cand_cluster    1..12689
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(not (POR or POR_N or PFOR_II) and
                     minimum(4, [Acyl-CoA_dh_1, Acyl-CoA_dh_2, ECH_2, ETF,
                     ETF_alpha, HCDH_N, Thiolase_N, ketoacyl-synt]) and HCDH and
                     minimum(1, [EC1_2-faecali, ECH1_Enoyl_CoA_DH1,
                     ECH1_Enoyl_CoA_DH2, ECH1_Enoyl_CoA_DH3, ECH1_Enoyl_CoA_DH4,
                     Thiolase_C]))"
                     /kind="single"
                     /product="acetate2butyrate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..12689
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="acetate2butyrate"
                     /region_number="1"
                     /rules="(not (POR or POR_N or PFOR_II) and minimum(4,
                     [Acyl-CoA_dh_1, Acyl-CoA_dh_2, ECH_2, ETF, ETF_alpha,
                     HCDH_N, Thiolase_N, ketoacyl-synt]) and HCDH and minimum(1,
                     [EC1_2-faecali, ECH1_Enoyl_CoA_DH1, ECH1_Enoyl_CoA_DH2,
                     ECH1_Enoyl_CoA_DH3, ECH1_Enoyl_CoA_DH4, Thiolase_C]))"
                     /tool="gutsmash"
     CDS             complement(487..1056)
                     /locus_tag="ctg75_1"
                     /transl_table=11
                     /translation="MKKTAVLLYDSFCNFEISVAMEVLVLGGKEVVVFGATKEPIRSED
                     GLLVIPQKELSELDIEEYDSLLLPGAMDIREAIENPRVIDFIKQFDNKIIGAISIAPIM
                     LVRAGILLGKAFMAGVNKEEIMGEGFSEEELSQMIGWDDNLKNPVQMGFVVTDNVVTSV
                     SYNFVRFGLKFGAMLGIDLPPETFGI"
     CDS             complement(1214..1345)
                     /locus_tag="ctg75_2"
                     /transl_table=11
                     /translation="VKTYIEERAMEIARYIIDNNTTVRQAAKHFGISKSTVHIDVTM"
     CDS             complement(1414..1710)
                     /locus_tag="ctg75_3"
                     /transl_table=11
                     /translation="MKDNRNRYNEEIEKYQSMDQFQVGIAVFDPGTTETHFYDNVRSVC
                     EMMNNNISISVGVTWAEHGKEFNEKIMEADWRMYEQKNAYHQQQQAAQQELLQ"
     CDS             complement(1713..1982)
                     /locus_tag="ctg75_4"
                     /transl_table=11
                     /translation="MCRADLTERAAEEKDMLVLAKEEENIVVNKPALSQIRSICELATL
                     ECYYHNVEKSAKTKGTGLAHVGEKEKNSGSNTPELLRLKSTCRM"
     CDS             complement(2198..4498)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) FMN_bind"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg75_5"
                     /sec_met_domain="FMN_bind (E-value: 1.5e-16, bitscore:
                     50.8, seeds: 891, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNISGIVPVILAAVVGIGAVVSLSDYTAPVYGSESEDELTETET
                     IIESAGMESVEETEVENTEAAVVLDGAFDLADGTYEGSANGFSGKIKVSVVIKNQTIRS
                     INILSNSDDAAFFNRAKEGVTASILAKQSTDVDTVSGATYSSRGIINAVNAGVSVCLCS
                     AELDMGAFDTVSRATTNHGLHRGSYQCTSEITKKDGTKLKVAYYTGAATGVLTNGETFS
                     YDKNEIESYVVTGLKYVPVKVKTEDYEAFKAAYTVVENGSTLSGGFSEENLKNYTDLVA
                     EVTENTNGLKTVTQNEDGSFSFAARVNNGTDSGIKDAALKTAENITTTVKEANGSYGEF
                     LRVDLTGEGYGALGADMQAVEWTYYGSDSTYTDPLQSYGTKFASDNWMHKAQGIQLGLT
                     DSLRCKLPAGTDGTGYWTITVYALGYNDYTVKFKVTDANIVKDEEETVDTTALEAAIKS
                     AENLTESDYTAASWSDLCVELKEAKDELAAPHTQSTVDEATEHLNAAIKALVKAETKEE
                     TKTDVTKLNAVIEKAEALKQSDYTAESWKNLQTALDAAKKLTDATAEQTVVDQAASDLE
                     TAILALVKADTENTGTTDKKKKPAVGTVKTVGQIKYKVTGKNTVTVNKYAKKNITKASI
                     PATVKINGYTFKVTAIADSAFSGCSKLTKVTVGSNVKAIGNKSFYKCTKLTTFTASSTG
                     LNKIGKEAFSGDKKLANITLKTTKLKKSGVGKDAFKNIKKNATFKVPAKKVSDYKAIFK
                     SKGAGKNIKVKKL"
     CDS             complement(4525..5565)
                     /locus_tag="ctg75_6"
                     /transl_table=11
                     /translation="MSEGKVKRKIIFLIFAAVMVVAGGCGTDGGDTEASRDLFAMDTYM
                     TVTAYGKGATEAVDQAADEISRLDQLLSTGNEDSEIYKINQSGDGILSEETAYLVERSL
                     DLYEATDGAFDIAIYPVMKVWGFTDDNFRVPDADELKDLLTLTDASDISYDKETSQIVF
                     KKDGMQIDFGGIAKGYTSARIMDIFRACGIKSGLVNLGGNVQALGTKKDGSSWRVAVQD
                     PQDTDQYLGVFSIQDKAVITSGGYERYFEQDGRTYHHIIDPKTGYPVENGLISVSIVTA
                     DGTLADGLSTSVFIMGKEAATEYWRNHSDEFDMILMTDDREIYVTEGIADSFESEMDTK
                     IIEKKV"
     CDS             complement(5761..6444)
                     /locus_tag="ctg75_7"
                     /transl_table=11
                     /translation="LRNEHASVILNNVVKLHITRKEEETMTQKKFSTKYLVEMALLVAI
                     ILIMAFTPIGYIRTAGLEITLIVVPVAVGAVTLGPAAGAILGGVFGVTSFIQCFGMSPF
                     GAALLGINGFLTFLVCVPTRILMGWLTGLIYKGLRKTKLPSGVSVTISNLCCPLLNTTF
                     FMGMLVIGFYNTEYIQSFVSALGAKNALLFILAFVGVNGLVEAIVCFVVGTAISAALKK
                     ALKYN"
     CDS             complement(6515..7123)
                     /locus_tag="ctg75_8"
                     /transl_table=11
                     /translation="MNKKKFSTKFLVEMALLVAIILIMAFTPLGYIKTAGIEITLIVVP
                     VAVGAVTLGPAAGAILGGVFGLASFLRCFGLNAFGAMLLSINPFLAFLLYVPTRILTGW
                     LTGLIYQGIRKTKIPSNVSITIANLCCPLLNTTFFMSMLVFGFYQTEYIQSFVQTLGVS
                     NPFLFVIAFVGINGLVEAVVCFIVGTAISAALKKALKYS"
     CDS             7426..7821
                     /locus_tag="ctg75_9"
                     /transl_table=11
                     /translation="MIQKKNVLNTVPVICLGALLLGSAYGQLHTPMTPPPITALASDIL
                     PTTGNVRALVVVVDFADAKYDTDRRLSDEEISSYLFGTDNTEFYPCESLTSYFDRASYG
                     SLHMTGNVFHYTAKGTIASYEKTADGS"
     CDS             complement(8176..9222)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: ETF"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: ETF_alpha"
                     /gene_functions="electron_transport (smcogs)
                     SMCOG1008:Electron-transferring flavoprotein (Score: 161.3;
                     E-value: 7.7e-50)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg75_10"
                     /sec_met_domain="ETF (E-value: 1.7e-50, bitscore: 161.3,
                     seeds: 129, tool: rule-based-clusters)"
                     /sec_met_domain="ETF_alpha (E-value: 7.4e-39, bitscore:
                     121.7, seeds: 511, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MALEEYKGVFVFAQQVDNVLDGVAFELLGKGKDLAKDLGTDVTAV
                     LIGSGVKGLADQLAEYGADKVIVVDDPELKDYRTEPYAHALASVINEFKPEIMLVGATA
                     IGRDLGPTVSARVKTGLTADCTSLEIGDFPLVAAPGKESEQKHNQLLMTRPAFGGNTIA
                     TIACPDNRPQMATVRPGVMQKIAPISGAKANVVEYNPGFTPNNRYVEILNIVKAVKSTA
                     NIMEAKILVSGGRGVGSKENFKLLEDLAEVLGGTVSCSRAVVENGWLPVDLQVGQTGKT
                     VRPQIYFAIGISGAIQHVAGMEDSDLIIAINKDEDAPIFDVADYGLVGDLNKIVPALTT
                     ALKAELGK"
     CDS             complement(9249..10031)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: ETF"
                     /gene_functions="electron_transport (smcogs)
                     SMCOG1008:Electron-transferring flavoprotein (Score: 159.1;
                     E-value: 3.7e-49)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg75_11"
                     /sec_met_domain="ETF (E-value: 8.3e-50, bitscore: 159.1,
                     seeds: 129, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNIVVCIKQVPDTKGGVKFNPDGTLDRAAMLAIMNPDDKAGLEAA
                     LRIKDETGAKVTVLTMGLPKADAVLREALAMGADEAVLVTDRVLGGADTWATSTTIAGA
                     LRNLDYDLIITGRQAIDGDTAQVGPQIAEHLGLPVISYAADIKVEGDSVVVKRQYEDRY
                     HELKAKMPCLVTALSELNEPRYMTPGGIFDAFDKEVTVWGRADLKDVDDSDLGLKGSPT
                     KIAKASDKVAKGAGEKVNLDPAESVAYLIGKFKEKHII"
     CDS             complement(10088..11242)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg75_12"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 7.7e-53, bitscore:
                     168.6, seeds: 49, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 2.8e-31, bitscore:
                     97.6, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 5.4e-40, bitscore:
                     126.6, seeds: 796, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDFTLDKKHEMARSLFKEFAETEVKPLAQETDETEAFPAETVKKM
                     QKYGFMGIPVPKEYGGQGCDPLTYVMCVEELSKVCATTGVVVSAHTSLCIDPIMTYGTE
                     EQKQKYVKPLATGEKLGAFALTEPGAGTDAQGAQTKAVLDGDEWVLNGSKCFITNGKVA
                     DVYIVIAITSITEDKRGRKKKNFSAFIVDKGAPGFSFGTKEKKMGIRGSSTYELIFEDC
                     RIPKENLLGPEGKGFPIAMHTLDGGRIGIAAQALGIAEGALDRAIAYTKERKQFGRSIA
                     QQQNTQFKLADMAARIEAAQLLVYKAAMAKATQKVYSVEAAKAKLFAAETAMAVTTEVV
                     QLFGGYGYIREYDVERMMRDAKITEIYEGTSEVQRMVISGALLK"
     CDS             complement(11272..12144)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: HCDH"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: HCDH_N"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg75_13"
                     /sec_met_domain="HCDH (E-value: 2.3e-35, bitscore: 111.1,
                     seeds: 68, tool: rule-based-clusters)"
                     /sec_met_domain="HCDH_N (E-value: 1.7e-63, bitscore: 203.6,
                     seeds: 60, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKVGVIGAGTMGQGIAKAFAQVEGYEVALCDIKQEWAEGGKEKIK
                     KGYARLVEKGKMTQEAVDGILAKITPGLKEDLCKDCDLIVEAAFENMEVKKTTFKELDE
                     IAKPDCIFASNTSSLSITEIGNGLNRPMVGMHFFNPADRMKLIEVIAGVNTPDETVSAI
                     KKISEEIGKTPVQVNEAAGFVVNRILIPMINEAAFIKMEGVSDIAGIDAAMKLGANHPM
                     GPLELGDFIGLDICLAIMDVLYKETGDSKYRACPLIRKMVRGGNLGAKSGKGFYVYNAD
                     RTKTPVDAQ"
     CDS             complement(12238..12687)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: Thiolase_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg75_14"
                     /sec_met_domain="Thiolase_C (E-value: 1.6e-52, bitscore:
                     166.3, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="AGNASGINDGAAAIVVMSEEKAKELGVTPMATWVAGALGGVEPEI
                     MGVGPVASTRKVLAKTGLSIDDMDLIEANEAFAAQSIAVARDLKFDMSKVNVNGGAIAL
                     GHPVGASGCRILVTLLHEMQKRDAKRGLATLCIGGGMGCSTIVER"
ORIGIN
        1 gcgaaagcta caccccctta cctcgcctgt ccttctctcc catactatga gaaggcttct
       61 tagattagac cagacctttt tatttaatct aagcataatc catttgaaat caaattacgt
      121 tccccaaata ctagactttt gtccattccc accgtacttt ttcaaaaatt gcactgctcc
      181 aggctgcacc atttttcatt caaaatcatg aaataaaaag aaacgcttga aaagagtttt
      241 atgttacgaa tctttttcaa acgtttctat accaattcaa tatacaattt tatgattagc
      301 atccgcttct ttgccttgtt ctttctaatt tcaaatttaa ttttaattct atattcacaa
      361 cttggcaagc agtgcatttg tacacacaca atgcgttttt acttgttgag aatatctccc
      421 aatccctcaa aatcaatcag aaatctgatt gaaccatata attctttttt caatttcatc
      481 cgaaaattat attccaaatg tttcaggagg caaatcaatt cctaacattg ctccaaactt
      541 aagaccaaat ctcacaaagt tgtatgaaac agatgtgaca acattatctg ttaccacaaa
      601 acccatttgc actggatttt ttaaattatc atcccaacct atcatctgag ataattcttc
      661 ttctgaaaat ccttctccca taatctcctc tttatttacg ccggccataa atgcttttcc
      721 taataatatt cctgctctca caagcataat cggtgcaata gagatagcac caataatctt
      781 gttatcgaac tgcttaatga aatcaataac tctcggattt tctattgcct cccgaatatc
      841 catagccccc ggaagaagta aactatcata ttcttcaatg tctaattcgc tcaattcttt
      901 ttgtggtata acaagcaaac catcttcact tcttataggt tctttcgttg ctccaaaaac
      961 aactacttcc tttcccccca agaccaatac ttccatcgca acacttattt caaaattgca
     1021 aaaagaatca tataataata ctgccgtttt cttcatacgt tttcaccctc ctcatatttt
     1081 ttactcattg tcttctaaaa ttcacacttc catctcatac atattatatc aaaatcactc
     1141 tcagatttcc acctgagagt gatcctactt tatccctatt caatcaccca aacaatctta
     1201 cctttaaatc gttctacatt gttacgtcta tatgtaccgt actcttgcta atcccaaaat
     1261 gtttcgccgc ctgacgcacc gtcgtattat tatcaataat atatctggct atttccatag
     1321 ctctttcctc aatataggtt ttcacaaaaa ctcccctgca atacttgttt ttacattgta
     1381 tgcaggggag ttatatacta ttctttcaaa catttattgc agcagttcct gttgtgcagc
     1441 ctgctgctgt tgatgatatg catttttctg ttcatacatc cgccagtcag cttccatgat
     1501 cttctcatta aattcttttc cgtgctctgc ccaggtaact cccactgaaa tgctaatatt
     1561 gttgttcatc atttcacaga cagatcttac attatcataa aaatgcgttt ctgtcgtacc
     1621 cggatcaaat actgcaatgc caacctgaaa ctgatccata ctctgatatt tttctatttc
     1681 ctcattgtat ctgttacgat tatctttcat atttacatcc gacatgtcga tttcagtctt
     1741 agcaactccg gtgtattcga tccagaattt ttttcttttt ctcccacatg tgccaatccg
     1801 gtaccttttg ttttcgcgga cttttccaca ttgtgataat aacattctag tgttgcaagt
     1861 tcacagatcg accggatctg tgacagggca ggtttattga caacaatatt ttcctcttcc
     1921 tttgccagca caagcatatc cttctcttct gctgcacgct ctgtcagatc cgctctgcac
     1981 atttcatacg cttcctgcga tatcgtttct gtttcatatt tttattttca aaaatataat
     2041 ccatagaacc aaaacctacc gccatgttct gtatctcact ctccggaagt gtgaggatga
     2101 ttgtttttgt ttcctcctca aaggttcaat tacacattcc attctacaat aaggtctctt
     2161 caccccctgt tttttaacaa aagaatattt tttcacccta cagtttcttt accttaatat
     2221 tttttccagc accctttgac ttaaaaatag ctttataatc agaaactttt tttgccggta
     2281 ctttaaaggt tgcatttttc ttaatgttct tgaatgcatc ctttccaaca cctgattttt
     2341 tcagttttgt tgtctttaat gtgatatttg caagtttttt atcaccggaa aacgcttcct
     2401 ttccaatctt gtttaatccg gtagaagatg ccgtaaatgt ggtaagtttt gtacatttat
     2461 aaaatgattt atttccgatt gcctttacat tagaaccaac cgtaactttc gtaagtttac
     2521 tgcatccgga aaatgcgctg tctgcaattg cagttacctt aaatgtatat ccgttgattt
     2581 taaccgttgc aggaatagat gcctttgtaa tgtttttctt tgcatattta tttacagtta
     2641 ctgtattttt tccggttact ttatacttga tctgtccaac tgttttcaca gttccaactg
     2701 ccggtttttt ctttttgtct gtagttccgg tattttccgt atcagctttt accagcgcca
     2761 aaatcgctgt ttccagatca cttgctgcct gatctactac agtctgttct gctgttgcat
     2821 ctgtaagttt ctttgcagca tcgagcgcag tctgtaaatt tttccagctc tctgctgtgt
     2881 aatcactctg ctttaatgcc tccgctttct cgattacagc gttaagtttt gtaacatctg
     2941 tttttgtttc ttcctttgtc tctgccttta ccagtgcttt gattgcagca ttcagatgct
     3001 ctgttgcctc atctacagta gactgcgtgt gcggagccgc aagctcatct tttgcctctt
     3061 tcaattcaac gcaaagatca gaccagcttg ctgccgtata atcactctca gttaagttct
     3121 ctgcactttt aattgcagct tcaagtgccg tcgtatccac cgtttcctct tcatccttaa
     3181 caatatttgc atcggttacc ttaaatttta ccgtgtaatc attgtaacca agtgcatata
     3241 ccgtgattgt ccagtatccg gttccgtctg ttcccgccgg cagtttacaa cgcagtgaat
     3301 ctgtaagacc aagctggatt ccctgtgctt tgtgcatcca gttatctgat gcaaacttgg
     3361 ttccataaga ttgaagtgga tcggtataag tactgtcgga tccataataa gtccactcta
     3421 ctgcctgcat atcagcacca agtgcaccgt agccctcccc agtcagatcg acacgaagaa
     3481 attctccgta agaaccgttt gcctctttta ccgttgttgt aatattctct gctgttttta
     3541 atgcagcgtc cttgattccg gaatccgttc cattgtttac tctcgcagca aacgaaaaac
     3601 ttccgtcctc attttgggta actgttttta gaccattggt gttttctgtt acttctgcaa
     3661 ccagatccgt atagtttttc agattttcct ccgaaaatcc accggataaa gtactgccat
     3721 tttccactac ggtatatgct gctttaaaag cttcataatc ttcagttttt actttgactg
     3781 gaacatattt aagtcctgtt accacatagc tttcaatctc atttttatca taggaaaaag
     3841 tctctccgtt cgtcagcaca ccggtggctg ctcctgtata atatgccact ttgagctttg
     3901 taccatcttt ttttgtaatt tctgacgtac actgataact tcccctgtgc agtccgtgat
     3961 tggtggttgc tctcgatacg gtatcaaatg cacccatgtc aagctcagcg ctgcataagc
     4021 atactgatac tcctgcgttt actgcattta tgattcctct tgaactgtat gttgcaccgg
     4081 aaaccgtatc cacatccgta ctctgctttg caaggatgct cgctgtcaca ccttcttttg
     4141 cacgattgaa aaaggctgca tcatctgaat tactcaaaat attgatcgac cggatcgtct
     4201 gattttttat cacaactgaa actttgatct taccggaaaa tccgttcgca ctgccttcat
     4261 aagttccgtc tgcaagatca aacgcaccgt ctaaaacaac agccgcttcc gtattttcaa
     4321 cttccgtctc ttctaccgac tccataccgg cactttcgat aatagtttcc gtctctgtca
     4381 gttcatcttc tgactctgaa ccataaaccg gtgctgtata atcactcagg gaaaccactg
     4441 caccaattcc caccaccgct gccagaatga cgggtacaat tcctgaaata tttttcatac
     4501 ttgtctccat accaaatcat tcgtttatac ttttttttca atgatcttcg tatccatttc
     4561 cgactcaaaa ctgtctgcga ttccctctgt gacatagatt tccctgtcat ccgtcatcag
     4621 aatcatgtca aattcatcac tgtgatttct ccaatattcc gttgcggctt ctttccccat
     4681 aataaaaacg gatgtagaaa gtccgtccgc aagcgttcca tctgctgtga caatggaaac
     4741 ggaaattaac ccgttctcca ccggataacc ggttttggga tctatgatat gatgatatgt
     4801 cctgccgtcc tgctcaaaat aacgttcata accgccggaa gtgatcaccg ccttatcctg
     4861 tatggaaaac accccaagat actgatctgt atcctgtggg tcctgcactg ccacgcgcca
     4921 gctgcttcca tccttctttg ttccaagtgc ctgcacattt ccaccaagat tgaccagtcc
     4981 gctcttgatc ccgcaggcac gaaaaatatc catgatacgt gcagaagtat aacctttcgc
     5041 gattcctcca aagtcgatct gcattccgtc ctttttaaaa acgatctgcg atgtctcttt
     5101 atcataagaa atatccgatg catctgtcag cgtgagcaga tccttaagtt cgtctgcgtc
     5161 cggcaccctg aaattgtcat ctgtaaatcc ccatactttc ataaccggat aaatcgcaat
     5221 atcaaatgca ccatctgtag cttcatacag atccagtgag cgttccacca gatatgctgt
     5281 ctcctccgag agtattccat ctccgctctg attgatttta tatatctcac tgtcctcatt
     5341 tcccgtagac aacaattgat ccagccggct gatctcatct gccgcctgat ccacggcctc
     5401 tgtggctcct ttgccataag cagttaccgt catatatgtg tccattgcaa agagatctct
     5461 gctcgcctcg gtatctcccc catcggtacc acagccacct gccacaacca tgactgctgc
     5521 aaaaatcaga aatataattt ttctttttac tttaccttcg ctcattttcc ctctaacttt
     5581 ggttagtatt ttctaatcat tttagcttac aatgcaccag acgcaaatgt caatctgcac
     5641 ttttgagact ttttctcatt ttgatctcca tttcccatgt taccgcaaaa aaatcccctc
     5701 acatacagac aacaacctgc atataagagg attcctcaat tatattatat ttcattcaat
     5761 ttaattatat ttcaatgcct ttttgagagc tgctgaaatc gccgttccca caacaaagca
     5821 gacaattgcc tcaaccagtc cgttgacacc tacaaatgct aaaatgaaca gcaatgcatt
     5881 ttttgcacca agagctgata caaatgactg gatgtattcc gtattgtaaa atccaatcac
     5941 taacattccc ataaaaaatg tggtgttcag cagcggacaa caaaggttgc tgatcgtaac
     6001 agatacacct gacggcagct ttgttttacg aagtccttta tagatcagac ctgtcagcca
     6061 tcccattaaa atacgggtag gtacgcatac taaaaatgtt aaaaatccgt tgattccaag
     6121 cagtgcagca ccaaatgggc tcatgccgaa gcactggatg aaacttgtaa caccgaacac
     6181 gccgcctaag attgcgcctg ccgccggtcc taacgtaaca gctcctaccg ctaccggaac
     6241 gacgatcagc gtgatctcaa gaccagctgt tctgatatat ccgatcgggg taaaagccat
     6301 gatgagaatg atagcaacta aaagtgccat ctccacaaga tactttgtgg aaaacttttt
     6361 ctgagtcata gtctcttcct cttttcttgt aatatgtaat tttacaacgt tattaagtat
     6421 aacacttgca tgctcattcc gcaatcccgc atccatattt acttcgtaat gtcatgtttt
     6481 tattttcatc caatttttac catattccat ccaattaact atatttcaat gctttcttca
     6541 aagccgcgga aattgcggtt ccgacgataa aacataccac cgcctcaacc agtccgttga
     6601 ttccgacaaa tgctatcaca aacaaaaacg gattgctgac accaagcgtc tgaacaaacg
     6661 actggatgta ctcggtctgg taaaacccaa ataccagcat gctcataaaa aacgtggtat
     6721 ttaaaagcgg acagcacaga ttcgcgattg tgattgatac attcgatggt atttttgttt
     6781 tgcggattcc ctgataaatc agtcctgtca gccagcccgt caggatacgg gtcggtacat
     6841 acagcaaaaa tgccagaaac ggattgatgc taagaagcat cgcaccaaat gcattcagtc
     6901 cgaagcagcg caaaaaactg gcaagtccaa atacacctcc taaaattgca ccagccgcag
     6961 gccctaaagt aacagctcct accgccaccg gaacaacgat cagtgtaatc tcaatacctg
     7021 ccgtcttaat gtatccgagt ggggtaaaag ccatgataag aatgatggca actaaaagtg
     7081 ccatttccac aagaaacttt gtggagaact ttttcttgtt catagtccct tcctcttttc
     7141 tcgtttttat gtaattttat acgaaacaca ggacgagcca tttgtagatc agtatgaatt
     7201 tccggcatcc tgtatctctg caacgttact aagtataaca tctggcagaa ttttccgcaa
     7261 tcttagattg cgttaatcct aaaatcctaa aattgtgcca ttctaagaat tgtactacca
     7321 cttttttata tttttattgt ttccttaatt atcaataaat gccattgact ttctgctttt
     7381 tgcgtgcaaa gctaaccata tatttataag aaaagagttt ttaccatgat acagaaaaaa
     7441 aatgtactta acaccgttcc ggttatctgc cttggtgccc tgcttttggg gtcggcatac
     7501 gggcagcttc acacgccaat gacgccgcca ccgattacag ctctcgcctc agatattctg
     7561 ccgacgacag gcaatgtccg agcacttgtt gttgtggtcg attttgcgga tgcgaaatat
     7621 gatacagaca gacgcctgtc cgatgaagaa atttcctcct atctgtttgg cacagacaat
     7681 actgaatttt atccctgtga gagcctgact agttattttg accgtgcttc atacggatca
     7741 ctgcatatga ccggaaatgt atttcattac acagcgaaag gtacgatcgc atcctacgaa
     7801 aaaacggcag atggatctta agactggtca ataacggaaa tggcttttac cgggacggtg
     7861 acgtgatcgg aggcactgcc acaggctttg gctggtatga caacaacgga cagttgacca
     7921 ttgataccgg gtatacgatc acggtcgact ccgtatctga ggatcagaaa aactgtacca
     7981 taacgatttt gacaaacaac taagtatatt ttccctcaac tcctgaccaa gagcctcaaa
     8041 tttcctccaa ctccaaacaa gaagcctcaa attttctcca gctcccagca aaaagcccgt
     8101 ccttcctgtc agcttcctca cagaagccgc acacgaaaga cgggctttct atcttacagg
     8161 ttattcacct atgtattatt tgcctaactc agcttttaat gctgttgtta aagcaggaac
     8221 gatcttattc agatcaccaa ccagaccgta atcagctacg tcgaagattg gagcatcttc
     8281 atctttgttg attgcgatga tcaggtcaga atcttccata ccagctacgt gctggattgc
     8341 tccggaaata ccgattgcaa agtagatctg aggacgaaca gttttaccag tctgacctac
     8401 ctgtaaatca actggtaacc agccattctc tacaactgca cgggagcagc ttacagtacc
     8461 gccaagtacc tctgcaagat cttccaaaag tttgaagttc tctttggaac caactccacg
     8521 accaccggaa acaaggatct ttgcttccat aatgtttgct gtgctcttaa cagcttttac
     8581 gatgtttaag atctcaacat atctgttgtt tggtgtaaat cccgggttgt actctacaac
     8641 gtttgctttt gcaccgctga tcggagcgat cttctgcata acacctggac gtacagttgc
     8701 catctgagga cggttgtccg ggcaggcaat tgttgcgatg gtgttaccac caaatgcagg
     8761 acgtgtcatt aataactggt tgtgtttctg ctctgattct ttaccaggtg cagcaaccag
     8821 tgggaaatca ccgatctcaa gagatgtaca gtctgctgtc agacctgttt ttactcttgc
     8881 agaaacagta ggtcctaagt cacggccgat agcagttgca ccaactaaca tgatttcagg
     8941 tttgaactcg ttaattacag atgctaatgc atgagcatac ggctctgttc tgtagtcttt
     9001 taattcagga tcatctacta cgataacttt gtcagcacca tactcagcta actgatctgc
     9061 taatcctttt acaccagaac caattaatac agcagttacg tctgtaccta aatcttttgc
     9121 taagtctttg ccttttccaa gtaactcaaa tgcaacgcca tctaatacgt tatctacctg
     9181 ctgtgcaaag acaaatactc ctttatattc ttctaatgcc atgttattca ccacttttcc
     9241 tttttttatt agataatgtg tttctctttg aatttaccga tcaaatatgc tacggattct
     9301 gccggatcaa ggtttacttt ctcaccagca ccctttgcaa ctttatcaga tgcttttgca
     9361 atcttagtag gagatccctt taaaccaaga tcagaatcgt caacatcctt taagtctgct
     9421 ctgccccaaa cggttacttc tttgtcaaat gcatcgaaga ttccgcccgg tgtcatgtaa
     9481 cgcggctcat ttaattcaga aagagcagtt accagacaag gcatttttgc ttttaactca
     9541 tgatatctgt cttcgtactg acgttttaca acaacagaat caccctctac tttgatgtct
     9601 gctgcgtaag agataaccgg aagtccaaga tgctcagcga tctgaggacc aacctgtgca
     9661 gtatcaccat cgatagcctg acgtcctgtg atgatcaggt catagtctaa gttacgaagt
     9721 gcaccagcga ttgtggtaga tgttgcccat gtatcagctc cacctaatac gcggtctgtt
     9781 acaagaactg cttcatcagc acccattgct aatgcttcac gaagaactgc atcagccttt
     9841 ggaagtccca tggtaagaac tgtaactttt gctcctgtct catctttgat tctaagtgct
     9901 gcttcaagac cagctttatc atctgggttc atgatagcaa gcattgctgc tctgtcaagc
     9961 gttccatccg ggttgaactt aacgccgccc tttgtatcag gaacctgttt aatacatact
    10021 acgatattca tgtatttttc actccttatg ttttatatgt ttaaatttta cgcggattga
    10081 ttcgaaatta ctttaacagt gcaccggaga ttaccatacg ctggacttcg cttgtaccct
    10141 cgtagatctc agtgatctta gcatcacgca tcatacgctc tacatcgtac tctctgatat
    10201 atccgtatcc accgaataac tgaacaacct cagttgtaac agccattgca gtctctgctg
    10261 cgaataattt cgcttttgca gcttctacag aatatacttt ctgagtagct tttgccattg
    10321 cagctttgta aactaaaagc tgtgcagctt cgattcttgc agccatatca gcaagtttga
    10381 actgtgtatt ctgctgctgt gcgattgaac gtccaaactg ttttctctct tttgtataag
    10441 cgatagctct gtctaatgca ccctcagcga taccaagtgc ctgagcagca ataccgatac
    10501 gtccaccatc aagtgtgtgc attgcgatcg ggaaaccttt tccttccggt cctaacagat
    10561 tctctttcgg gattctgcag tcttcgaaga tcagctcata agtagatgat ccacggatac
    10621 ccatcttctt ctcttttgtt ccgaatgaga agcctggagc tcccttatct acgataaatg
    10681 cagagaagtt cttcttcttt ctgcctctct tgtcctctgt gatgcttgtg atagcgatta
    10741 caatataaac atctgcaact ttaccattgg taatgaagca ttttgatcca tttaataccc
    10801 actcgtcacc atctaaaaca gcttttgtct gtgcaccctg tgcatcagta ccagcacccg
    10861 gctcagttaa tgcgaatgca cctaacttct cgcctgttgc aagtggtttt acatatttct
    10921 gtttctgctc ttctgtacca tatgtcatga tcggatcgat gcagagagat gtatgtgcag
    10981 atacaacaac acctgtggtt gcgcaaactt tagataactc ttctacgcac ataacgtatg
    11041 taagaggatc acaaccctgt ccaccatatt ctttcggaac cgggattccc atgaatccgt
    11101 atttctgcat tttcttaacc gtttctgccg ggaaagcttc tgtctcatct gtttcctgtg
    11161 caagcggttt tacttctgtt tcagcaaatt ccttgaataa ggaacgcgcc atttcatgtt
    11221 tcttgtctaa agtgaaatcc atgatctaat tttcctccat aaatatttat tttactgagc
    11281 atcgaccgga gtctttgtac gatcagcatt gtatacatag aatcccttgc cgctctttgc
    11341 tccaaggtta ccaccacgaa ccatcttacg gatcagtggg catgcacgat atttgctgtc
    11401 gcctgtctct ttgtaaagta catccatgat agcaaggcag atatcaagac cgatgaaatc
    11461 acctaactct aacggtccca ttgggtggtt agcaccaagt ttcatagctg catcgatacc
    11521 agcgatatcg gaaacacctt ccattttgat gaatgcagct tcgttgatca ttgggattaa
    11581 gatacggttt acaacgaaac cagcagcctc attaacctgt accggagttt ttccgatctc
    11641 ttcagaaatt ttcttaatag cggaaacagt ttcatccgga gtattcacac cagcgataac
    11701 ctcgatcagt ttcatacggt ctgccgggtt gaagaaatgc ataccaacca ttggacggtt
    11761 taatccgttt ccaatctctg taatagaaag actggatgtg ttggaagcga agatacaatc
    11821 tggttttgcg atctcgtcta attctttgaa agtagttttc tttacttcca tattctcgaa
    11881 agctgcctct acgatcagat cacagtcttt gcaaaggtct tcttttaaac ctggagtgat
    11941 ttttgcaagg atgccatcaa cagcttcctg tgtcattttt cctttttcta ctaatcttgc
    12001 ataacctttt ttgatcttct cttttccgcc ttcagcccac tcctgcttga tatcgcaaag
    12061 tgctacttca tatccttcta cctgagcaaa tgcttttgca atgccctgtc ccatagttcc
    12121 tgcaccaata acgccaacct tcatttcggt tacctcctga aaataattat gttaactgta
    12181 tgtttgaaaa atgcaatccc cgggaagtca ttccccggga attactataa aaaactatta
    12241 tctctcaacg attgtagagc atcccatacc accgccgatg caaagtgtag caagacctct
    12301 cttagcgtct ctcttctgca tctcatgcag taatgtaaca aggatacggc atccggaagc
    12361 acctaccggg tgtcctaatg cgattgcacc accgtttacg tttacttttg acatatcgaa
    12421 tttcagatct cttgctactg cgatagactg agctgcgaat gcttcgtttg cttcgattaa
    12481 gtccatatca tcaatagata aaccagtttt tgctaatact tttcttgtag aagcaacagg
    12541 tccaacaccc atgatctcag gctcaactcc gccaagagca cctgctaccc atgtagccat
    12601 tggtgtaaca ccaagctctt ttgctttttc ttcactcata acaacgattg ctgctgcacc
    12661 atcgttgata ccggaagcgt tacctgctg
//
