LOCUS       c00022_gnlPro..        12989 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|OJDEPEII_22.
ACCESSION   c00022_gnlPro..
VERSION     c00022_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-07 07:17:40
            Original ID  :: gnl|Prokka|OJDEPEII_22
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 12989
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12989
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[1:2989]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      2..2989
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..12989
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..12989
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             2..1339
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg22_1"
                     /sec_met_domain="TPP_enzyme_C (E-value: 2.6e-47, bitscore:
                     151.1, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="NFVGITQAVTKWNCQVKRTEDIPAAIAKAFYIARSGRPGPVVVDI
                     TKDAQCGTAPFRYEKITSIRSYLPAPAPDAERIAEAARLIDQARRPLVMVGQGVILGNA
                     EAELRALLDKSGMPAASTLLGLSALPTDHPQNVGMLGMHGNYGPNIKNQECDLLVAVGM
                     RFDDRVTGNPAHFGANAKVIHLEIDPAKIGKIIPADVAVVGDVKRSLPLITERIRKRDH
                     SQWIAGFRACDQIEYEAVIRKAVHPAEGRIRMGEAVAAVARAYRNDAVLVTDVGQQQMN
                     AARYFGFRRTRSVVTSGGLGTMGFGLPAAIGAKLGAPDREVVLFAGDGGLQMTIQELGT
                     IFQSKIPVKIVLLNNSFLGMVRQWQELFYDRRYSFTEMVNPDFGLIARGNGLSYRCVER
                     REELDEAIAAMKASEGAFLLEVRVEGEENIFPMVPAGAPVSEIRFE"
     CDS             1353..1904
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg22_2"
                     /sec_met_domain="ALS_ss_C (E-value: 6.9e-19, bitscore:
                     58.7, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEQEYIITVFSENKVGLLSQITTVFTCRDVNIESLTTSESALQGI
                     HKFTIVVRTTPDQVDKLVRQVEKKIDVLKTFVYTPDEVVQQEIALYKVTRSRGVEQLVR
                     EHNVRILEIDDDYIVVEKTGHKADTQALFRLLQPYGVQQFVRSGTVAIIKSRRELLNEY
                     LEEIDRLRAESDEEGSKSEK"
     CDS             1943..2989
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: IlvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg22_3"
                     /sec_met_domain="IlvN (E-value: 2e-46, bitscore: 148.3,
                     seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="IlvC (E-value: 1.3e-45, bitscore: 145.9,
                     seeds: 295, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAKINFGGVEENVVTREEFPLEKALETLKDETIAVIGYGVQGPGQ
                     SLNLRDNGFRVIVGQREGSASWDKAVADGWVPGQTLFGIEEAAERATIIQYLLSDAGQI
                     AVWPSIKKHLTPGKALYFSHGFGITYKERTGIVPPADVDVILIAPKGSGTSLRRMFLQG
                     RGLNSSYAVFQDATGRAFERVVALGIGVGSGYLFETDFKREVYSDLTGERGTLMGAIQG
                     IFAAQYDTLRANGHTPSEAFNETVEELTQSLMPLVSENGMDWMYANCSTTAQRGALDWW
                     KKFRDATKPVFEELYREVAAGNEAQRSIDLNSKPDYREKLNEELREMRESEMWQTGAVV
                     RKLRPENN"
     CDS             3124..4230
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ROK"
                     /gene_functions="other (smcogs) SMCOG1034:Repressor, ORF,
                     Kinase (Score: 71.3; E-value: 3.1e-22)"
                     /gene_kind="other"
                     /locus_tag="ctg22_4"
                     /sec_met_domain="ROK (E-value: 1.2e-22, bitscore: 71.3,
                     seeds: 11, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYSHDNRVVITLDAGGTNLVFGAMQANKFIVEPITLPSHAENLDK
                     CLATMVEGFQAVIDRLSEKPVAISFAFPGPADYPNGIIGGYLPNFPSFREGVALGPFLE
                     AKFGIPVYINNDGDLFAYGEALGGALPEVNARLEALGSPKKYKNLVGYTFGTGLGVGLV
                     IDNRLNRGDNSCVETFCLRHKKMPEIIVEDGASIRAVKRVYGEASGDVNHTFEPKDICE
                     IAEGKRPGDVEAAKKAFAEMGEIAGDAMATAVTLVDGLIVIGGGITAARKWIMPSLLNE
                     LRSKMHQLNGNELNRVQMKVYDLDDETEFREFAKGAQRPLKVYGTDRYVAYDPQKRIGV
                     TISKLGASQAISVGAYAFALSQLDTENA"
     CDS             4243..5208
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PMI_typeI"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg22_5"
                     /sec_met_domain="PMI_typeI (E-value: 2.3e-13, bitscore:
                     40.7, seeds: 8, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYKFQPILKSLIWGGEKIAPYKGIATDQRNIGESWELSGVKDNES
                     VVAEGPEAGTSLPELIARHGAALLGKANYGRFGEEFPLLIKFIDARQDLSIQVHPNDEL
                     AWERHKSKGKTEMWYVVSADKDAHLRSGFSKQVTPAEYEASVGDNTITDILADYKIAPG
                     DVFFLPAGRVHSIGAGSFIAEIQQTSNITYRIYDFNRRDANGNTRELHTELAKGAIDYT
                     VLPDYRTHYEPAQDTRVELVSCPYFTTSLYDLTRPETLDLASLDSFVVAICIEGRGTLT
                     DDSGAAVPVHQGETVLIPASARSLAFTPDGGMKILTSWIG"
     CDS             complement(5287..7536)
                     /locus_tag="ctg22_6"
                     /transl_table=11
                     /translation="MKKYLILIFVALAAVFQSCDNNDDLWDAIDDLKSRVQALETQVDA
                     LNGNIEALQKLYGGATISKVETSDGKYLITLTNGETIELVQGSEAEAVIPIVSINDKGE
                     WQVSTDNGATFTSLGVKAVAEDGTTPRFRIDEATGYWQVSYDGGTSFENVKDTKGQPVK
                     AIGSGTVTDKFFEEVKVDGGDLYIRLLGGEELRIPIVSDFFCRIVTPTEGVQTFDAGAT
                     KRFVVEIRGVEQVKLSAPEGWSARLTDAVDERAELIVTAPAAVTRATADTSKDVAIEAF
                     AAGGLSTVAKIQVESTGTAPAAPTVAVTNSATVEPTQSALTFDVAPSANADGWKYLCLK
                     STETAPDAARVLAEGTAGTGTGVTVGNLEANTAYTIYVVAYAGDLTSEVASVGNTTAEA
                     PVTAEADYYQDYQDGKDIALGDLTINKTVYPEAQLLKPSELTAAIITAGGLIFVDNSDA
                     ADLSFTISGASINMGDIVLIGRYPERAQATISGPELRCKYNAAFKNLHIAASGNYNLFT
                     TTNATYDPTLHVEDCTVDAAYNVVYDSHNTQNFKSVYFGNSIVKMTVANKPFYSTKAKD
                     AHTQQLIRLDNNVFYAETPLQNYLINCGDRSQAFQTPRLQVEVTNNTIYNIYQPNIMIR
                     AYVLAGLTVTKNVGYYTGVTAKNYLTGVYDTAGFTADKAEVTYNYLYTAPVSDTNFWSA
                     KHTGSYTPANNQMGDGVEAPFSSMDAAKGYFPVDASVVKTGAGATYDTKAWFKTE"
     CDS             complement(7557..10118)
                     /locus_tag="ctg22_7"
                     /transl_table=11
                     /translation="LWIAAASAFVLQSCENTDGIRDEIGSLRDRVIALEAKIGSVNTSI
                     VALHKLMDESTIIVGIEPNAKGYEIELSDGTRLPVILGEKIEALVPVMGIDAEGYWTVS
                     LDGGATSERLKVGGEYVSAWPVSGGDHKPGAEGVTPQLKVSADGEWLVSLDGGATYAPL
                     LQNGQPVNALGDKVVVSYSSAFKSVTYDATTGLLAVELLDGEKLTLPVFDDFGLTVTAS
                     DNETFRLGETRAFEVVQNNVAEAVIDAPAGWTAVLGETTLTVKAPATFDAASQQAAVSV
                     TVYSDRKYRKLVTLNVTLLDEQVDANAALAWRNFKAGTADNVLLDYSYAGYKHGEEAPA
                     DVWGLGYKVYNVVDYGADPTGVRSSRGALTALLKELKLSGRSDAGANLANANARAVIYF
                     PEGRFVLHNDDDNVVDPTSANQKYTDSKGNNRSEEIFIRGGYFVLKGAGRGKTTLVMDT
                     PNLPNNSEQMWSSPMMINIKHNSGLSDLTTVTGDAARGTFSVEVASAAGIGKGDWVCLS
                     LSNNDPTLVAQELAPHRVEGNMTDIQTITVEDYHQVASVSGNRVTFAEPIMYAVEAKWG
                     WKIRKYPHYEHVGVEDLTFEGRSKENFGHHASWEDDGAYKPLNMMRLTDSWIRRVDFRG
                     VSEALSIVSSANCSAYDIEISGNRGHSGVRSQSSSRIFIGKVCDRSRGQAVSPPYTSTG
                     YFENAGQYHASGVSNTSLGAVLWNNTWGDDAFFESHSRQPRATLVDRCTGGFVQWRFGG
                     DETNVPNHLGDLTIWNLNATRAAHDFGAEPFKWWLSSDKWWKTMPPIIVGFHGAAVTFD
                     ESAEQVKYLESNGAAVEPLSLYEAQLRQRLGYVPAWLNSLK"
     CDS             complement(10147..11685)
                     /locus_tag="ctg22_8"
                     /transl_table=11
                     /translation="MLKIRIAIPFAGLALTACGQSEAGRPNVIYVFPDQYRNSSLGFWS
                     DPEFAAEVGWKGDPVATPNLDRFAREATVLTEAVSNFPVSSPHRGMLLSGMYPERNGVV
                     LNCMSERPESSLREDAECIGDVFSAAGYDCAYIGKLHADFPTKNNPQRPGTYVSDAVPE
                     WDAYTPPERRHGFNYWYSYGTYDVHKHPHYWDTDGNRHDVDEWSPRHEVSKAIEYIENK
                     GGVRDPEKPFLMMIGMNPPHSPYASTDDCDLEGYERYKDKSLTELLVRDNADTTMAKAA
                     AVRYYFANVSGIDREFGRLLAALDRAGLTENTIVVFASDHGETMTSHSTDDPKNSIWRE
                     SLNIPFLVRYPGRVPHRVDDLLLSTPDIMPTLLGLAGLGERIPASVEGRDYSAVLRQDA
                     VQPERPRAALYMRNLDGGRDADGLVRGFFAQARGVKTAAHTMELRIGRDGTLERVLMFD
                     DAADPYQLHNLAPEEHPALFAALCRELAVLLRDNDDVWFREGVLSDVVPYDTNN"
ORIGIN
        1 caatttcgtc ggcatcacgc aggccgtaac caaatggaac tgccaggtca agcgcaccga
       61 ggacattccc gcggccatcg ccaaggcctt ctacatcgcc cgctcgggcc gtccgggtcc
      121 cgtcgtggtc gacatcacca aggacgcaca atgcggaaca gctccgttcc gctacgaaaa
      181 aatcacctcg atccgcagtt acctccccgc gcccgcaccc gacgcggaac gcatcgccga
      241 agccgcacgg ctgatcgacc aggcccgccg tccgctggtc atggtgggcc agggcgtcat
      301 cctgggcaac gccgaagccg agctgcgggc actgctcgac aagagcggca tgcccgccgc
      361 ctcgaccctg ctgggtctct cggccctgcc gaccgaccat ccgcaaaacg tgggcatgct
      421 gggcatgcac ggcaactacg gacccaacat caagaatcag gagtgcgacc tgctcgtggc
      481 cgtgggcatg cgtttcgacg accgcgtgac ggggaatccc gcgcatttcg gcgccaacgc
      541 caaggtgatc cacctggaga tcgaccccgc gaagatcggc aagatcatcc cggccgacgt
      601 ggcggtcgtg ggcgatgtga aacgctccct gccgctcatc accgagcgta tccgcaaacg
      661 cgaccacagc caatggatcg ccggattccg cgcctgcgac cagatcgaat acgaagccgt
      721 catccgcaag gccgtgcatc ccgccgaggg gcgtatccgc atgggcgagg cggtcgccgc
      781 cgtggcccgg gcttaccgca acgacgcagt gctggtgacc gacgtaggcc agcagcagat
      841 gaacgccgca cgctatttcg gattccgccg cacgcgcagc gtggtcacct cgggcggtct
      901 cggcacgatg ggattcggac ttccggcggc catcggggct aagttgggcg cccccgaccg
      961 cgaagtcgtc cttttcgccg gcgacggcgg cctgcaaatg accattcagg agctgggcac
     1021 gatcttccag tcgaagatcc ccgtgaaaat cgtcctgctg aacaactcgt tcctcggcat
     1081 ggtgcgccaa tggcaggagc tgttctacga ccgccgctac tcctttacgg agatggtcaa
     1141 ccccgatttc gggctgatcg cccgcggcaa cggcctttcg taccgctgcg tcgaacggcg
     1201 cgaggaactc gacgaggcca tcgccgccat gaaggcctcc gaaggcgcct tcctgctgga
     1261 ggtgcgcgtc gagggcgaag agaacatttt cccgatggtc ccggcgggcg ccccggtatc
     1321 ggaaatccgg ttcgaataaa acgaaacagc gtatggaaca ggaatacatc atcaccgtgt
     1381 tttcggagaa caaggtgggc ctgctgagcc agatcaccac cgtcttcacc tgccgcgacg
     1441 tgaacatcga gagcctcacg acctcggaat cggcgttgca gggcatccac aaattcacca
     1501 tcgtggtccg caccacaccc gatcaggtcg acaaactcgt gcggcaggtc gagaagaaga
     1561 tcgacgtgct gaagaccttc gtctacaccc ccgacgaggt cgtgcagcag gagatcgccc
     1621 tctacaaggt gacccgcagc cggggcgtcg aacaactcgt cagggaacac aacgtccgca
     1681 ttctggagat cgacgacgac tacatcgtcg tcgagaaaac cggccacaag gccgacacgc
     1741 aggcgttgtt ccgcctgctg caaccctacg gcgtacagca gttcgtgcgc agcggcacgg
     1801 tggccatcat caagtcgcgg cgcgagctgc tgaacgagta ccttgaagaa atcgaccgtt
     1861 taagggccga atccgatgaa gaagggagca aaagcgaaaa ataactttca gaacatataa
     1921 caaactaaaa atcacgaaaa ccatggcaaa gatcaatttc ggcggcgtcg aagagaacgt
     1981 cgtaacccgc gaggaatttc ctctggaaaa agcgctcgaa acactcaagg acgagaccat
     2041 cgccgtcatc ggctacggcg tgcaaggccc cggacagtcg ctcaacctgc gcgacaacgg
     2101 attcagggtc atcgtgggcc agcgcgaagg ctccgcgagc tgggacaagg ccgtagccga
     2161 cggctgggtg ccgggccaga cgcttttcgg catcgaggag gccgccgagc gcgccacgat
     2221 catccagtac ctgctctccg acgccgggca gatcgccgta tggccttcaa tcaaaaagca
     2281 cctcacgccg ggcaaggccc tctatttctc ccacggcttc ggcatcacct acaaggagcg
     2341 cacgggcatc gtgcccccgg ccgacgtgga cgtgatcctg atcgccccga aaggctcggg
     2401 aacctcgctg cggcgcatgt tcctccaggg ccgcggactc aattcgagct atgcggtgtt
     2461 ccaggacgcc acgggccgcg ccttcgaacg cgtcgtggcg ctgggcatcg gcgtgggttc
     2521 gggctacctg ttcgaaaccg acttcaagcg cgaggtctac tccgacctca cgggcgagcg
     2581 cggcacgctg atgggcgcca tccagggcat cttcgccgcc cagtacgaca cgctgcgcgc
     2641 caacggccac accccctcgg aggccttcaa cgaaacggtc gaggagctga cccagtcgct
     2701 catgccgctg gtctcggaga acggcatgga ctggatgtac gccaactgtt cgaccacggc
     2761 ccagcgcggc gcgctggact ggtggaagaa gttccgcgac gccacgaagc ccgtcttcga
     2821 agagctgtac agggaggtgg ccgccggcaa cgaggcccag cgttcgatcg acctgaacag
     2881 caaacccgac taccgcgaga agctcaacga ggagctgcgc gagatgcgcg aaagcgagat
     2941 gtggcagacc ggcgccgtcg tgcgcaagct gcgtcccgaa aacaactgac acaaggcaag
     3001 gtcctgaaaa aggccggcgg cagcagtcgc cggccttttt cgcgcaattc ggttttgcac
     3061 ccgttcaatt tttatgtatc tttgcctgcc ggaacaccga caatccaaac aaaactactc
     3121 aatatgtaca gccatgacaa ccgggtggtc atcaccctcg acgccggcgg cacgaacctc
     3181 gttttcggcg ccatgcaggc caacaaattc attgtggagc cgatcaccct cccgtcgcat
     3241 gccgagaacc tcgacaaatg cctcgcgaca atggtcgaag ggttccaggc cgtcatcgac
     3301 cgtctgtccg aaaaacccgt agccatcagt tttgcattcc ccggcccggc cgactatccg
     3361 aacggcatca tcggcggtta tctgcccaac ttcccgtcgt tccgcgaagg cgtggcgctg
     3421 ggtccgttcc tcgaagcgaa attcggcatc ccggtataca tcaacaacga cggcgacctg
     3481 ttcgcctacg gcgaggcgct gggaggcgcc ctgcccgagg tcaacgcccg gctcgaagcg
     3541 ctgggaagcc cgaagaaata caaaaacctc gtcggctaca ccttcggcac gggactcggc
     3601 gtgggccttg tgatcgacaa ccggctgaac cgcggcgaca actcatgcgt cgagacgttc
     3661 tgcctgcgtc acaagaaaat gcccgaaatc atcgtcgagg acggggcgtc gatccgtgcc
     3721 gtgaaacgcg tctacggcga agcttcgggc gacgtgaacc acaccttcga accgaaagat
     3781 atctgcgaaa tcgccgaggg taaacgcccg ggagatgtcg aggccgcgaa gaaggctttt
     3841 gccgaaatgg gcgagatcgc cggcgacgcc atggctacgg ccgtgacgct ggtggacggc
     3901 ctgatcgtca tcggcggcgg catcacggcg gcccgcaaat ggatcatgcc cagcctgctg
     3961 aacgagctgc gttcgaagat gcaccagctc aacggcaacg agttgaaccg cgtgcagatg
     4021 aaggtttacg atctggacga cgagacggag ttccgcgaat tcgccaaggg cgcgcagcgg
     4081 cccctgaaag tctacggcac ggaccgctac gtggcctacg acccgcagaa acgcatcggc
     4141 gtgaccattt cgaaactcgg cgcgagccag gccatttcgg tcggagcata cgctttcgcc
     4201 ttgagccagc tcgacacgga aaacgcataa aatagatcga ccatgtataa atttcaaccg
     4261 attctgaaat ccctgatctg gggcggcgag aagatcgccc cttacaaggg aatcgccacc
     4321 gaccagcgca acatcggcga aagctgggag ctttcgggcg tcaaggacaa cgagtccgtc
     4381 gtcgccgaag gccccgaagc cgggacatcg ctcccggaac tgatcgcccg tcacggcgcg
     4441 gcgctgttgg gcaaagccaa ctacgggcgt ttcggcgagg agttcccact gctgatcaag
     4501 ttcatcgacg cccggcagga cctctcgatc caggtgcacc cgaacgacga gctggcatgg
     4561 gaacgccaca aatccaaggg caagaccgaa atgtggtacg tggtgtcggc ggataaggac
     4621 gcgcacctgc gttcgggctt ctcgaagcag gtaacgccgg ccgagtacga ggccagcgtc
     4681 ggggacaaca ccatcacgga catcctggcc gactacaaga tcgcaccggg cgacgtattc
     4741 ttcctgcccg cgggacgtgt gcactcgatc ggcgcggggt cgttcatcgc cgaaatccag
     4801 cagacctcga acatcaccta ccgcatctac gatttcaacc gccgcgatgc caacggcaac
     4861 acccgcgaac tgcacaccga actggcgaag ggcgccatcg actacaccgt gctgcccgat
     4921 taccggacgc attacgagcc ggcgcaggac acgcgcgtgg agctggtgtc gtgcccttat
     4981 ttcaccacgt cgctctacga tctgacccgc cccgagacgc tcgacctcgc gtcgctcgac
     5041 tcgttcgtcg tggcgatttg catcgagggc cgcggtacgc tcaccgacga cagcggcgca
     5101 gcggttccgg tgcaccaggg cgaaacggtc ctgattccgg cttcggcccg ttcgctcgcc
     5161 ttcacgcccg acggcggcat gaagattctg acaagctgga tcggctgatc cgcctcttcg
     5221 gctcaacgaa aaaaactccg gcctgcgaaa atgcaggccg gagtttttcg ttacggcaag
     5281 ccggaattac tccgtcttga accacgcctt cgtgtcgtag gtcgctcctg cacccgtctt
     5341 caccaccgaa gcgtcgaccg ggaaataccc cttcgccgca tccatcgaag agaacggagc
     5401 ttccacgccg tcgcccatct ggttgtttgc aggcgtgtag cttccggtat gcttcgccga
     5461 ccagaaattc gtatcgctga ccggcgcggt gtagaggtaa ttataggtta cctccgcctt
     5521 gtcagccgta aatccagccg tgtcatacac acccgtcaga taatttttcg cggtaacacc
     5581 ggtataatac ccgacattct tggtcacggt cagccctgcg aggacataag cccggatcat
     5641 aatgttcggc tggtaaatgt tataaatcgt attgttcgtc acctcgacct gaagccgggg
     5701 cgtctggaat gcctgcgacc tgtccccgca gttgatcagg tagttctgca aaggcgtttc
     5761 ggcataaaat acgttgttat ccagacgaat caactgctgc gtatgcgcgt ccttcgcctt
     5821 ggtcgaatag aacggcttgt tggcgacggt catcttcaca atcgaattcc cgaaatagac
     5881 actcttgaaa ttctgcgtat tgtgcgaatc gtaaaccaca ttgtaggcag catccacggt
     5941 acaatcctcg acatgcagcg tcggatcata ggtggcattg gtcgtcgtaa agaggttgta
     6001 attgcccgaa gccgcgatat gcaggttctt gaaagccgca ttgtacttgc aacgcagttc
     6061 cggcccggag atcgtcgcct gcgcacgttc gggataacgg ccgatcagca cgatgtcgcc
     6121 catattgatc gacgcgcccg aaatcgtgaa cgacagatcg gcagcatcgg agttgtcgac
     6181 gaaaatcaaa cctccggccg taatgatcgc agcggtcagt tcggagggct tgagcagctg
     6241 cgcttccgga tagaccgtct tattgatcgt caggtcgccc agcgcgatgt ctttcccgtc
     6301 ctgataatcc tggtagtagt ccgcctcggc ggtaacggga gcctccgccg tcgtgttccc
     6361 gacgcttgcc acctcgctcg tcagatcgcc ggcataggcg accacgtaga tcgtataggc
     6421 cgtattggct tcgagattcc cgaccgtcac gcccgtaccc gtaccggccg tgccttcggc
     6481 aagaaccctg gcggcgtcgg gagccgtttc cgtcgatttg aggcagaggt atttccagcc
     6541 gtcggcattg gccgagggcg caacgtcgaa ggtcagcgcc gactgcgtgg gttcgaccgt
     6601 cgcggagttg gtcaccgcaa ccgtcggagc ggcgggagcc gttccggtgc tctcaacctg
     6661 gattttggcc accgtcgaaa gcccgccggc cgcaaaggcc tcgatcgcca cgtccttcga
     6721 cgtgtcggcc gtggcgcggg tcacggctgc gggggccgtc acgatcagtt cggccctctc
     6781 atccacggca tcggtcaggc gtgccgacca gccctcggga gccgacagtt tcacctgctc
     6841 gacacctcgg atctccacca cgaaacgttt ggtggccccg gcgtcgaacg tctgcacacc
     6901 ctcggtcggc gtgacgatcc ggcagaagaa atcgctcacg atcggaatgc gcagttcctc
     6961 gccgccgagc agcctgatat agaggtcgcc gccgtcgacc ttcacctcct cgaagaactt
     7021 gtcggtcacc gtacccgagc cgatggcctt gacgggctgg cccttggtgt ccttcacatt
     7081 ttcgaaggag gtgccgccgt cgtagctcac ctgccagtag ccggtggcct cgtcgatgcg
     7141 gaaccggggc gtcgtgccgt cctcggccac ggccttcacg ccgagcgagg tgaacgtggc
     7201 tccgttgtcg gtcgacacct gccactcgcc cttgtcgttg atcgagacga tcggaatcac
     7261 ggcctcggcc tcgctgccct gcaccagttc gatggtctcg ccgttggtca gcgtgatgag
     7321 atatttgcca tcggaggtct cgaccttgga gatcgtggcg ccgccgtaga gtttctgcaa
     7381 cgcctcgatg ttgccgttca gcgcgtcgac ctgcgtttcg agcgcctgca cgcggctctt
     7441 caggtcgtcg atcgcatccc acaggtcgtc gttgttgtcg cacgactgga aaaccgcagc
     7501 cagcgcgacg aagatcagga tcagatactt tttcataata tgtttggttt tttattctat
     7561 ttcaatgaat tgagccatgc ggggacatac cctaaccgct ggcgcagctg cgcttcgtag
     7621 agcgacagcg gctcgacggc cgcgccgttg ctttcgaggt atttcacctg ttcggcgctc
     7681 tcgtcgaagg tgaccgccgc gccgtggaat ccgacgatga tcggcggcat ggtcttccac
     7741 cacttgtccg aggagagcca ccacttgaac ggttcggccc cgaaatcgtg cgccgcacgc
     7801 gtggcgttca gattccagat cgtcaggtcg cccaggtggt tgggcacgtt ggtttcgtcg
     7861 ccgccgaaac gccattgcac gaatccgccc gtgcagcggt cgacgagcgt ggcgcgcggc
     7921 tgcctggagt gcgactcgaa gaaggcgtcg tcaccccacg tgttgttcca cagcacggcc
     7981 cccagcgagg tgttcgacac acccgaggcg tggtactgtc cggcgttttc gaaatacccc
     8041 gtgctcgtat agggcggcga gacagcctgc ccgcggctgc ggtcgcagac cttgccgatg
     8101 aagatgcgcg acgaggactg cgagcgcacg cccgagtggc cgcggttgcc gctgatctcg
     8161 atgtcgtagg ccgagcagtt ggcgctcgac acgatcgaca acgcctcgct gacgcccctg
     8221 aaatcgacgc ggcgaatcca cgaatcggtc agacgcatca tgttgagcgg cttgtaagcc
     8281 ccgtcgtcct cccacgaagc gtggtggccg aagttctcct tcgagcgacc ctcgaacgtg
     8341 aggtcctcga caccgacatg ttcataatgg gggtatttgc ggattttcca gccccatttg
     8401 gcctccacgg cgtacatgat cggttcggcg aaggtcacgc ggttgccgct tacggaagcc
     8461 acctggtgat agtcctcgac cgtaatggtc tgaatatcgg tcatgtttcc ctcgacccgg
     8521 tgcggcgcca gctcctgcgc caccagcgtc gggtcgttgt tcgaaagcga aaggcacacc
     8581 cagtcgccct tcccgatgcc ggccgccgaa gccacctcca ccgagaacgt gccgcgtgcg
     8641 gcgtcgcccg tcaccgtcgt gaggtccgaa agtcccgaat tgtgcttgat attgatcatc
     8701 atgggcgacg accacatctg ctccgagttg ttcggcaggt tgggcgtgtc catgacgagc
     8761 gtcgtcttgc cgcggcccgc gcccttgagc acgaaatacc ccccgcggat gaaaatctcc
     8821 tcgctgcggt tgtttccctt cgaatcggtg tatttctggt tggcggaggt tgggtccacc
     8881 acgttgtcgt cgtcgttgtg gaggacgaaa cgcccctcgg ggaaatagat caccgcccgg
     8941 gcattggcat tcgcgaggtt cgcccccgca tcgctccgcc cggaaagttt cagctccttg
     9001 agcagcgcag tcaacgcccc gcgcgaggac ctgacgcccg tgggatcggc gccgtagtcg
     9061 acgacgttgt aaaccttgta gcccagtccc cagacatcgg ccggagcctc ctcgccgtgc
     9121 ttgtaaccgg catacgaata atcgagcagg acgttatccg cagttccggc cttaaaattc
     9181 cgccatgcca gagcggcgtt ggcatccacc tgctcgtcga gcagcgtcac gttcagcgtg
     9241 acgagtttcc ggtatttcct gtccgaatag accgtcaccg agaccgccgc ctgctgcgaa
     9301 gcggcgtcga acgtcgcggg agccttgacc gtcagcgtcg tctcgccaag cacggccgtc
     9361 cagcccgcag gcgcgtcgat caccgcctcg gcgacgttgt tctgcacgac ctcgaaagcc
     9421 cgggtctccc cgaggcggaa agtctcgttg tcggaagccg tcaccgtcag tccgaaatcg
     9481 tcgaagacgg gaagcgtgag tttttcgccg tcgagcagtt cgaccgccaa aagtccggtc
     9541 gtcgcgtcgt aagtcaccga cttgaaagcc gaactgtaac tgacgacgac tttatccccc
     9601 aaggcattga ccggctgtcc gttttgcaaa agcggcgcgt aggtcgcccc gccgtcgagg
     9661 ctcacgagcc actccccgtc ggccgaaacc ttcagctgcg gggtgacgcc ctcggcgccg
     9721 ggcttatggt cgccgcccga aacgggccat gccgaaacgt actctccgcc gaccttcagc
     9781 cgctcggaag tggctccgcc gtcgaggctc acggtccagt agccctcggc gtcgatgccc
     9841 atgacgggaa ccagcgcctc gatcttctca ccgaggatga cgggcagccg ggttccgtcg
     9901 ctcaactcga tctcgtaccc ctttgcgttg ggttcgatcc cgacgatgat cgtcgactcg
     9961 tccatcaact tgtggagcgc cacgatggag gtgttcacgc tgccgatctt cgcctccagc
    10021 gcaatcaccc gatcgcgcag gctcccgatc tcgtcgcgga tgccgtcggt gttctcacac
    10081 gattgcagca caaaagccga ggccgctgca atccacaaaa acaatttatt catatccgat
    10141 tgattgttag ttattcgtat catagggaac cacgtcggac aagacgccct cgcggaacca
    10201 cacgtcgtcg ttgtcgcgca gcaacacggc cagttcgcgg cacagcgcgg cgaacagcgc
    10261 gggatgctcc tccggcgcga ggttgtgcag ctggtaggga tcggccgcat cgtcgaacat
    10321 cagcacgcgt tcgagcgtcc cgtcgcggcc gatacgcagc tccatcgtat gcgctgcggt
    10381 cttcacgccg cgcgcctggg cgaagaagcc gcggaccagt ccgtcggcat cgcgcccgcc
    10441 gtcgaggttg cgcatgtaaa gggcagcgcg cgggcgttcg ggctgcacgg cgtcctgccg
    10501 cagcacggcc gagtagtcgc gcccctcgac actcgcggga atccgctccc cgaggcccgc
    10561 cagccccagc agcgtcggca tgatgtcggg cgtcgagagc agcagatcgt ccacacggtg
    10621 cggcacccgc cccggatagc gcaccagaaa gggaatgttc agcgactcgc gccagatcga
    10681 gttcttaggg tcgtcggtcg aatggctggt catcgtctcg ccgtggtccg aagcgaagac
    10741 cacgatcgtg ttctccgtaa gccccgccct gtccagcgca gcgagcaggc ggccgaactc
    10801 gcgatcgata ccgctcacgt tggcgaaata gtaacgcacg gcggcggcct tggccatcgt
    10861 cgtgtcggcg ttgtctcgca cgagcagttc ggtcagcgac ttgtccttgt aacgttcata
    10921 cccctccagg tcgcagtcgt cggtcgaagc gtagggcgaa tgcggcggat tcatgccgat
    10981 catcatcagg aacggttttt cgggatcgcg cacgccgccc ttgttttcga tatattcgat
    11041 ggctttcgaa acttcgtgcc gcggcgacca ctcgtcgaca tcgtgacggt tgccgtcggt
    11101 atcccagtaa tggggatgct tgtgcacgtc gtaggtgccg taggagtacc agtagttgaa
    11161 cccgtggcgg cgttcgggcg gcgtgtaggc gtcccactcg ggaacggcgt cgctgacgta
    11221 ggttcccgga cgctgggggt tgttcttcgt cgggaagtcg gcgtgcagct tgccgatgta
    11281 ggcgcagtcg tagcccgccg ccgagaagac gtcgccgata cactcggcgt cctcgcgcag
    11341 cgaactttcg ggacgctccg acatgcagtt cagcaccacg ccgttccgct cgggatacat
    11401 gcccgaaagc aacatgcccc ggtgggggct gctcacgggg aaattgctca ccgcctcggt
    11461 cagcaccgtg gcttcgcggg cgaagcggtc gaggttgggc gttgcgaccg gatcgccctt
    11521 ccaccccacc tcggcggcga actccggatc gctccagaac cccagcgagg agttgcgata
    11581 ctggtccgga aatacgtaga tcacgttggg gcgcccggcc tccgactgcc cgcaggccgt
    11641 cagggcgagg cccgcaaacg gaattgcaat tctaattttc aacatcgtgt cttatttcat
    11701 ttcaatcagg ttcacttcgc gcgtcgcacc ttcgcggctc gtgaagatca aagcggtgtt
    11761 ttcgcccgcg ggttcgatcc ggcactccgg cctatcgtct gcggactgcc agcggccgcg
    11821 gatcacgacc tccagctgcg actctcccga gggattgtcg atccacttgc gggagtagac
    11881 gctccgctcg gcgcgcctgc cgtcggcatc gaacacctcg tcgctcggcc cctcgtagaa
    11941 acgcaggtcg gggtccgcag cgctcaccgt cagcccttcg ccatccccgc cgatcatcac
    12001 cagcgaaggc agcgaaacgc tttccagcaa cccctcgccc accttaccgg ccgcaaaaag
    12061 ggcatagccc gtaatgcccg acagcctgtc gcgcaggata tgcgccgagg cgtcgcggcg
    12121 cagcacctcg tagggaagtt cccgcgcgta gcgggccgcc tcttcgtccg aagcgtgcac
    12181 ggccagcatg tattcgtacc cgccgccgct gacggacccg ctgccgtgat ctatccacgc
    12241 cgttgcgaaa ttgttctgcg tcggggcgtc ggtctcctcg tcgagcgaac gctgaagtga
    12301 tttcgaaacg actaccctac ctttcggcac gaagtaagcg ttgcgcaggt tgtcgcgcag
    12361 gacggcgccg cccgcaagtt cggcccggta ggggaactgc gtcaccgcct cgccgttcac
    12421 gacgagcgga tcggccccgt ccgccagaaa attctggaac agcgtcgtat gcacaccgcc
    12481 ctcggccttg ttttcgatgt cggaacccat acagacgatg cggttgtcga agaaaaacca
    12541 cgacttgcgc gcccgcagcg aaccgttgta tttgtcgtgc tcgtggagtt ccatcgcgaa
    12601 caccccgtcg cggcccctgt ggctgacgcc tccggcgaag gcctcgtcgg agaggagcat
    12661 ctcctcgtag cccgacgcgg tgtcgacgtt ccggatatcg gccttcatcc gctccatcgg
    12721 gattttgagc gccgtcgtcc cgggaatgtg ccgccagtcc cagccctcct gccggaaccc
    12781 gctgccgaag gcgctcacgg gatcgccgtc tgcaagcagc tgcatgctgc cgtgcgtcag
    12841 gtagcggccg tagtggttgg ctccctggta aatctccgcc gaccagagat agcggctgtg
    12901 gcccgcgacg gtcaccagcc agtcggcgcg ccggtgcgac accgaggcat tgtagccgta
    12961 gacgcggttc cccgcaggcg aaggttcgg
//
