LOCUS       c00129_gnlPro..         9150 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|DOPIIBCM_129.
ACCESSION   c00129_gnlPro..
VERSION     c00129_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-07 05:24:45
            Original ID  :: gnl|Prokka|DOPIIBCM_129
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 9150
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..9150
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[164:6258]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      165..6258
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..9150
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..9150
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             165..1547
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ILVD_EDD"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg129_1"
                     /sec_met_domain="ILVD_EDD (E-value: 8.1e-149, bitscore:
                     485.5, seeds: 918, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKHQLRSSFSTQGRRMAGARALWTANGMKKEQMGKPIIAIVNSFT
                     QFVPGHVHLHEIGQFVKEEIEKLGCFAAEFNTIAIDDGIAMGHDGMLYSLPSRDIIADS
                     VEYMVNAHKADAMVCISNCDKITPGMLMAAMRLNIPTVFVSGGPMEAGEWNGQHLDLID
                     AMIKSADESVGDKEVAQIEQHACPTCGCCSGMFTANSMNCLNEAIGLALPGNGTIVATH
                     ENRKRLFEDAAKLIVANAFRYYEEGDESVLPRSIATREAFLNAMTLDIAMGGSTNTVLH
                     LLAVAHEAGADFKMDDIDMLSRKTPCLCKVAPNTQKYHVQDVNRAGGIIAIMDELAKGG
                     LVDTNVRRVDGMTLAEAIDRYSITSSNVCKEAIKKYSSAAAGKFNLVLGSQNASYKELD
                     TDRATGCIRDLEHAYSKDGGLAVLKGNIAQDGCVVKTAXXXXXXXXXXXXXXXXXXXXX
                     XX"
     CDS             1624..1968
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ILVD_EDD"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg129_2"
                     /sec_met_domain="ILVD_EDD (E-value: 1.4e-45, bitscore:
                     144.9, seeds: 918, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQEMLYPTSYIKSRHLGKECALITDGRFSGGTSGLSIGHVSPEAA
                     AGGNIGKIKDGDIIEIDIPNRSINVKLTDEELAARPMTPVTRNREVSKALKAYASMVSS
                     ADKGAVRLID"
     CDS             2060..3811
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg129_3"
                     /sec_met_domain="TPP_enzyme_C (E-value: 6.8e-48, bitscore:
                     151.4, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MADNNKKSNFSSLSQGEGRGEALITGAEALMRSLEHQGVKTIFGY
                     PGGSIMPVFDALYDHRKELNHILVRHEQGATHAAQGFARVSGEVGVCLVTSGPGATNTI
                     TGIADAMIDSTPIVVIAGQVGTNFLGTDAFQEVDLVGITQPITKWSYQIRRAEDVAWAV
                     ARAFYVAKSGRPGPVVLDFAKNAQVEKTEYAPTKVDYVRSYLPVPEMEPEAIRKAAELI
                     NGAKRPLVLVGQGVELGEAQQELRAFIEKAGMPAGCTLLGLSALPTNHPLNKGMLGMHG
                     NLGPNINTNKCDVLIAVGMRFDDRVTGKLETYAKQAKIIHFDIDPAEIDKNVKTDVAVL
                     GDCKETLAAVTQLLEPANHQEWIDSFRQYEEVEEEKVIRPELHPAGKALSMGEVVRAVS
                     EATHNEAILVTDVGQNQMMSARYFKYSKERSIVTSGGLGTMGFGLPAAIGATFGRPDRT
                     VCVFMGDGGLQMNLQELGTIMEQKAPVKMILLNNNFLGNVRQWQAMFFNRRYSFTPMMN
                     PDYMKIASAYDIPARRVMTREELAKAIDEMIATDGPFLLEACVEEEGNVMPMTPPGGSV
                     NQMLLEC"
     CDS             3844..4404
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg129_4"
                     /sec_met_domain="ALS_ss_C (E-value: 4.8e-20, bitscore:
                     60.8, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKKLYTIIVHSENFAGLLNQVTAVFTRRQINIESLNVSASSIKG
                     VHKYTITAWTDKDTIEKVTKQITKKIDVLQAHYFTDDEIYQHEIALYKITTPTLEEKPE
                     VSKVIRKYNARIVEVNAVFAIVEKNGMSEEITNLYEELRQLDCVLQFVRSGRVAITTSC
                     FERVNEYLADREAKYRQSKHQES"
     CDS             4401..5033
                     /locus_tag="ctg129_5"
                     /transl_table=11
                     /translation="MMSENNKIGTYKFVAEPFHVDFTGRLTMGVLGNHLLNCAGFHASD
                     RGFGIATLNEDNYTWVLSRLAVELDEMPYQYEDFSIQTWVENVYRLFTDRNFAILDKEG
                     KAVGYAXXXSVWAMISMNTRKPADLLALHSGSIVDYVCDEPCPIEKPSRIKVASKEPVA
                     ALVAKYSDIDINGHVNSIRXXXXXXXXXXXXXXXXXXXXXXXLKWHM"
     CDS             5215..6258
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: IlvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg129_6"
                     /sec_met_domain="IlvN (E-value: 3.1e-47, bitscore: 149.3,
                     seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="IlvC (E-value: 2.8e-41, bitscore: 130.3,
                     seeds: 295, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAQLNFGGVIENVMTREEFPLEKAREILKDETIAVIGYGVQGPGQ
                     ACNLRDNGFNVIVGQRPGKTYEKAVADGWVPGETLFGIEEACQKGTIIMCLLSDAAVMS
                     VWPTIKPYLTPGKALYFSHGFAITWNDRTGVVPPKDIDVIMVAPKGSGTSLRTMFLEGR
                     GLNSSYAVYQDATGKAFDKTIALGIGIGSGYLFETTFIREATSDLTGERGSLMGAIQGL
                     LLAQYEVLRENGHTPSEAFNETVEELTQSLMPLFAKNGMDWMYANCSTTAQRGALDWMT
                     PFHDAIKPVVQKLYASVKSGNEAQISIDSNSKPDYREKLNAELKALRESEMWQTAVTVR
                     KLRPENN"
     CDS             complement(6320..8233)
                     /locus_tag="ctg129_7"
                     /transl_table=11
                     /translation="MITFATMKEQDSNSPIIHLQQQQVLLRMEYEYEKEEFKRQTENMG
                     VARKVKRGLCWYPATPGRSYYNSLNQLVIEITHTENTDIEHNFEFGRPVCFFRQSADGK
                     ITYMNFTATVSYADETRMVAIMPGAGAVMEVQETDNLGVQLYFDETSYRTMFEALEDTL
                     RSKGNRLAELRDILLGTSKAGFRELYPVRFPWLNSTQETAVNKVLCARDVAIVHGPPGT
                     GKTTTLVEAIYETLHREPQVLVCAQSNTAVDWISEKLVDRGVNVLRIGNPTRVNDKMLS
                     FTYERRFENHPLYPELWSIRKNLRELGSRARRGSYDEREGVRSRMSRLRDRATALEIQI
                     NAELFDGAHVIASTLVSSNHRLLNGRRFGTLFIDEAAQALEAACWIAIRKADRVVLAGD
                     HCQLPPTIKCYEAARGGLERTLMEKVVSNKPAVVSLLKVQYRMHEEIMKFPSQWFYNGE
                     LEAAPEVRYRGILDWDTPIHWIDTSEMDFKEEFVGETFGRINKAEADLLLSELKIYINR
                     IGGNRILEEKIDIGIISPYKAQVQYLRSKIKADASLKPYRSLFTVNTVDGFQGQERDVI
                     FISLVRANEEGQIGFLNDLRRMNVAITRARMKLVILGEAETLKHHGFYRKLLEFIQNIG
                     NQ"
     CDS             8348..9148
                     /locus_tag="ctg129_8"
                     /transl_table=11
                     /translation="MVYDLTMLKTFYAAYSEKIERVRNVLRRPMTLAEKILYAHLYDGD
                     KVKNYRRGEDYVNFRPDRVAMQDATAQMALLQFMNAGREQVAVPSTVHCDHLIQAYKGA
                     KEDVATATKTNEEVYNFLRDVSSRYGIGFWQPGAGIIHQVVLENYAFPGGMMVGTDSHT
                     PNAGGLGMVAIGVGGADAVDVMTGMEWELKKPRLIGVHLKGKLSGWVAPKDVILKLAGI
                     LTVKGGTNAIIEYFGPGTASLSATGKATICNMGAEVGATTSLFPY"
ORIGIN
        1 ttacatacat ctattaacct ggcagtcctg catattattc gcgtcgtggt ggtggcatca
       61 agagcgtgag aaaggttatg tatgtattcg tacgttagaa gataatttat taagcctttc
      121 tcactatagt gggagaggct ttttcattaa aaggagattt gaaaatgaag catcagttac
      181 gcagctcgtt cagcacacaa ggtcgccgca tggcgggagc ccgtgcattg tggacggcga
      241 atggtatgaa gaaggaacag atgggtaagc ccattatcgc tatagtcaat tcatttacac
      301 aattcgtccc cggacatgta cacctgcacg aaataggcca gtttgtaaag gaagagattg
      361 aaaagctggg gtgttttgct gcggagttca atacgattgc cattgacgac ggtatcgcta
      421 tgggacacga cggtatgctt tattccctgc cttcaagaga tatcattgcc gatagtgtgg
      481 agtatatggt aaatgcccat aaggcggatg ctatggtttg catcagtaac tgtgacaaga
      541 ttactccggg gatgttgatg gcggctatga ggctgaatat accgactgtg tttgtttcag
      601 gcggtccgat ggaagccggg gaatggaacg gacaacattt ggatttgatt gatgctatga
      661 ttaaatctgc tgatgaaagt gtgggcgata aagaggtggc acagattgag caacatgcct
      721 gccccacttg cggatgctgc tcaggcatgt ttaccgctaa ttccatgaat tgcctgaatg
      781 aagcgattgg attggcactg cccggtaacg gcacgattgt agccactcac gaaaatcgca
      841 agagactgtt tgaggatgca gctaagttga ttgtagcgaa tgcctttaga tattatgaag
      901 aaggggatga gagtgtactc ccgcgcagta ttgctactcg cgaggcattt ttgaatgcca
      961 tgacgctgga tattgcgatg ggcggttcca ctaatacagt acttcatttg ttggctgtgg
     1021 ctcacgaagc cggagcggat tttaagatgg acgacattga catgctctct cgcaagaccc
     1081 cctgcttatg caaggtagct cccaataccc aaaagtatca tgtacaagac gttaaccgtg
     1141 ccggtggcat cattgccatc atggatgagc ttgccaaggg cggattggtc gatacgaatg
     1201 tccgccgtgt ggatggaatg acgttggcag aggcaatcga ccggtatagt attaccagct
     1261 ctaatgtatg taaagaggca atcaagaaat actccagtgc ggcagccgga aagttcaatc
     1321 tggtactcgg ctcacaaaat gcgtcttata aggaactcga tacggaccgt gcgactggtt
     1381 gtatccgtga tttggaacat gcatacagca aggatggcgg tctggcggtt ttgaagggaa
     1441 atatagctca ggacggttgc gttgtcaaga ctgcnnnnnn nnnnnnnnnn nnnnnnnnnn
     1501 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nntgtgacgg tattctgggt
     1561 ggaaaggtgg tcagtggaga cgtcgtcgtc atcactcacg aagggccgaa aggtggaccg
     1621 ggtatgcaag agatgcttta tcctacttct tatatcaaat cccgccatct gggtaaggag
     1681 tgtgcattga ttaccgacgg gcgttttagt ggcggtactt ccggactaag tatcggacat
     1741 gtttctcccg aagcggctgc cggtggtaat atcggcaaga ttaaggatgg ggacattatc
     1801 gaaattgata taccgaaccg ttctatcaat gtgaagttga cggatgaaga gcttgcagca
     1861 cgccctatga ctccggtaac ccgcaaccgt gaagtctcca aagcattgaa agcatatgcc
     1921 agtatggtga gttccgctga caaaggggct gtgaggctga ttgattaaaa gccccccttt
     1981 ccgaaagcga ggggaggaga gaatgaaaca aatttttcaa gctactattg agcttttaaa
     2041 tataatgaat agataaagta tggctgataa taataaaaag agtaactttt cctccctctc
     2101 ccaaggagag ggtcggggtg aggctctaat aacaggcgca gaagcattga tgcgctctct
     2161 ggagcatcag ggagtaaaga ctattttcgg ttatccggga gggagcatca tgccggtatt
     2221 cgatgcctta tacgaccatc ggaaggaatt gaaccacatc ttggttcgtc atgaacaagg
     2281 agcaacccat gcggcacaag gctttgcacg tgtatcaggc gaggttggcg tttgtctggt
     2341 taccagtgga ccgggtgcta ccaatactat cacgggcatt gcagatgcca tgattgacag
     2401 tacgcctatc gttgtcattg ccggccaggt agggacgaac ttcttgggta cggatgcatt
     2461 tcaggaagtg gacttggtag gcattactca gcctatcacg aaatggagtt accagattcg
     2521 tcgtgcagaa gatgtggcct gggcagtggc acgtgctttc tatgtggcaa agagcggacg
     2581 tccgggaccg gtcgtgctgg attttgctaa aaacgcccaa gtggagaaaa cagaatatgc
     2641 gcctactaag gtggactatg tccgtagcta tcttcccgtt cccgaaatgg agccggaggc
     2701 catacggaag gctgctgaat taataaatgg tgcgaaacgg cctttggtgc tggttggaca
     2761 aggcgtggag ctgggagaag cccagcaaga gcttcgtgct ttcattgaga aagccggaat
     2821 gcctgccgga tgcactttat tgggactttc cgcattacct acgaaccatc cgttgaacaa
     2881 aggaatgctt ggtatgcacg gtaacctggg gcccaatatc aataccaata aatgtgatgt
     2941 ccttatcgcc gtaggcatgc gctttgatga ccgtgtgacg ggtaaattgg aaacatatgc
     3001 caagcaggcg aagattatcc actttgatat tgaccctgcc gaaatagata agaatgtaaa
     3061 gactgatgtt gctgtcctgg gagattgcaa agagacactg gctgccgtta cccaattgct
     3121 ggaacccgcc aaccatcagg aatggattga cagtttccgg caatacgagg aagtggaaga
     3181 ggaaaaggta atccgtccgg aattacatcc ggcaggaaaa gcgctaagca tgggtgaggt
     3241 ggtgcgtgct gtgagtgagg ctacccataa cgaggcgata ttggtgactg atgtcggcca
     3301 gaatcagatg atgtccgccc gttatttcaa atacagcaag gaacgtagca ttgttacttc
     3361 cggtggcctg ggtactatgg gcttcggcct tccggcagct atcggtgcca cttttggacg
     3421 tccggaccgc acggtatgcg tattcatggg agacggcggc ttgcagatga acctgcagga
     3481 actgggtacc atcatggaac aaaaggctcc ggtgaagatg attctgttga acaataactt
     3541 cttgggcaat gttcgtcaat ggcaggcgat gttcttcaat cgtcgttatt cgtttactcc
     3601 gatgatgaat ccggattata tgaagattgc ttcggcatat gatattcctg cacgcagggt
     3661 aatgacccgc gaggagctgg caaaagcgat tgacgagatg atagcgactg acggaccgtt
     3721 cctgctcgaa gcttgtgtgg aggaagaagg aaatgtaatg ccgatgacac ctccgggcgg
     3781 ttcggtcaat cagatgttgt tggaatgctg aagtcatgcg aaattaaaga atttactcta
     3841 tctatggata aaaaactata tacaatcatt gttcattcgg aaaactttgc cggtttgctg
     3901 aatcaggtga cggctgtgtt tacccgccgg cagataaaca tcgagagttt gaatgtatcg
     3961 gcctcctcca tcaagggggt acataaatat accattaccg cttggacgga taaggatacc
     4021 attgaaaagg tgaccaagca gattaccaag aaaatagatg tgctgcaagc ccattatttc
     4081 acggatgatg aaatctatca gcacgagatt gccctttata aaataacgac ccctacgctg
     4141 gaagaaaaac cggaggtgtc caaagtaatc cgtaagtaca atgcccgtat tgtggaggtg
     4201 aatgctgtat ttgccattgt tgagaagaat ggcatgagtg aggaaataac caatctttat
     4261 gaggagttgc gccagttgga ttgcgtactt cagttcgtcc gttcgggtcg cgtagccatt
     4321 acgaccagct gctttgagcg tgtcaatgaa tatctggcgg accgtgaagc aaaatatcgt
     4381 caaagtaaac accaggaatc atgatgagcg agaacaataa aataggtacc tacaagtttg
     4441 ttgccgaacc gtttcatgtc gactttaccg gacggctgac aatgggagta ttgggcaacc
     4501 atttgttgaa ttgtgcgggt ttccatgcca gcgaccgcgg ttttggcatc gcgactctaa
     4561 acgaggacaa ttatacttgg gtattgtccc gtctggctgt cgaactggat gaaatgcctt
     4621 atcagtacga agatttctcc attcagactt gggtggagaa cgtgtatcgc ctttttacag
     4681 accgtaattt tgcaattttg gataaggaag gaaaagctgt cggatacgcn nnnnnnnnnt
     4741 ccgtttgggc gatgattagc atgaataccc gtaagccggc agatttgctg gctcttcata
     4801 gtggcagcat tgtagattat gtttgcgatg agccttgccc gatagaaaaa ccttcgcgga
     4861 taaaggtggc ctcaaaggaa ccggttgctg ctttggtagc caaatacagt gatattgaca
     4921 ttaacgggca tgtgaacagc atccgttnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     4981 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnttgaa atggcatatg tagccgaaag
     5041 ctattatggg gatgagttga ctttgttcat ggatgatgcc ggtgagggcg tttacgatgt
     5101 ggaggtgaaa aagaatggca gcgaagtggt ctgtcgctct aaagtgatat ttacagagaa
     5161 ataaataaat ttatcaacgt tggcgtaagc cacaaataaa aattaaaaca aaaaatggca
     5221 caattgaatt ttggcggtgt tattgagaat gtaatgaccc gcgaagaatt tcctttggaa
     5281 aaagcacgtg agattttgaa agatgaaaca attgcagtaa tcggttatgg cgtacaaggc
     5341 ccgggccagg cttgcaactt gcgtgataac ggtttcaatg tgattgtagg acaacgtccg
     5401 ggtaagacat acgaaaaggc tgtggctgac ggatgggtac cgggtgagac tttgttcggc
     5461 atcgaagagg cttgtcagaa aggtactatc atcatgtgtc tgttgtctga cgcagctgta
     5521 atgtctgtat ggccgactat caaaccttat ttgactcccg gaaaggctct ttacttctct
     5581 catggttttg ctattacctg gaacgaccgt accggcgtgg ttcctcctaa agatattgat
     5641 gttattatgg ttgctcccaa aggttccggt acttcacttc gtaccatgtt cctcgagggt
     5701 cgtggcttga actcatcata tgccgtctat caggatgcta cgggtaaggc ttttgacaag
     5761 acgattgcac tgggtatcgg catcggttcg ggatatttgt tcgagacaac tttcatccgc
     5821 gaagccactt ccgacttgac cggtgaacgc ggttcattga tgggtgctat ccagggattg
     5881 ctgttggctc agtatgaagt attgcgcgaa aacggccata ctccttctga agcattcaat
     5941 gaaacagtgg aagagttgac tcaatctttg atgccattgt ttgccaagaa cggtatggac
     6001 tggatgtatg ccaactgttc tactacggca cagcgtggtg cgctggattg gatgaccccg
     6061 ttccatgatg ccatcaagcc ggttgtacag aaattgtatg caagtgtgaa gtcgggcaac
     6121 gaagctcaga tttctatcga cagtaactcc aaacccgatt atcgtgagaa gctgaatgca
     6181 gaattgaaag ccttgcgtga aagcgaaatg tggcagacag ctgttacagt tcgtaaactt
     6241 cgtccggaaa acaattaatc agctttatat aaataggtga aataccctct tcggtgttac
     6301 cggagggggt atttctttat tattgattcc ctatattttg aataaactcc aatagcttcc
     6361 ggtaaaaacc gtgatgtttc agcgtctctg cctctcccaa tatcaccagc ttcatacgtg
     6421 cccgggtgat ggctacattc attctcctta aatcattcag gaatcctatc tgtccttctt
     6481 cgttggcacg gacaaggctg atgaagataa catcgcgctc ttgcccttgg aagccatcca
     6541 ccgtatttac agtgaacaag ctgcgataag gcttgagtga agcgtctgcc tttatcttgc
     6601 tgcggagata ttgcacttgt gccttgtaag gggagatgat gccgatgtct attttttctt
     6661 ccagaatgcg gttgccaccg atacggttga tgtagatttt cagttctgat aggagcaggt
     6721 ccgcttccgc cttattaatg cgtccgaaag tctctcccac aaattcttct ttgaaatcca
     6781 tttcggaggt gtcaatccag tggatggggg tatcccagtc caggatgccc cggtaacgca
     6841 cttcgggagc ggcttccaac tcgccattat aaaaccattg ggaaggaaat ttcatgattt
     6901 cctcgtgcat gcggtattgt actttcagca aagagacaac ggcaggtttg ttggacacca
     6961 ctttctccat caatgttcgt tccagacctc cacgggcagc ttcgtagcat tttatagtgg
     7021 gcggaagttg gcagtggtca cccgccaaca ccacgcggtc tgcttttcgg atagctatcc
     7081 agcaggcagc ttctaaggcc tgggctgctt catcaatgaa aagggtgccg aaacggcgtc
     7141 cgttcagcag ccggtgattg ctgcttacta gcgtggaggc tatgacatgt gccccatcaa
     7201 aaagctctgc attgatttgt atttccaatg cggtggcgcg gtcgcgcagg cggctcatac
     7261 ggctgcgtac tccttcgcgt tcgtcatagc tgccacggcg ggcacggctg cccagttcac
     7321 ggagattttt ccggatgctc cacagctccg gataaagcgg atggttctcg aaacgacgct
     7381 cgtaggtaaa ggaaagcatc ttgtcgttga cacgggtcgg attgccgata cgcaggacat
     7441 tgacgccacg gtccacaagt ttttccgaaa tccagtcgac ggcagtattg ctttgggcac
     7501 ataccagtac ctgcggttcc cgatgcaggg tttcgtagat ggcttccact aaggtggtcg
     7561 tttttccggt tcccggagga ccgtgtacaa tggccacgtc gcgggcacac agcactttgt
     7621 ttacagctgt ctcctgcgtg gagttcagcc agggaaaccg tacgggatag agctctcgga
     7681 aaccggcttt cgaggttccc agcaatatgt cccgcaattc ggccaggcgg ttgcctttgg
     7741 agcgtaacgt atcttccaag gcttcgaaca tggtccgata ggatgtttcg tcgaaataaa
     7801 gttgcacgcc gaggttgtcc gtttcctgca cttccataac ggcaccggct ccgggcatta
     7861 tcgctaccat ccgtgtctcg tcggcatagc ttacggtagc ggtgaagttc atataggtta
     7921 tttttccatc agcagactgg cggaaaaaac atacgggacg gccgaactca aaattatgtt
     7981 ctatatcggt attttctgtg tgtgtaattt ctattactaa ttgattcagt gaattatagt
     8041 aacttcgtcc cggagtggca ggataccagc aaagtccccg tttcactttc cgggcaactc
     8101 ccatgttttc ggtttggcgt ttgaattcct ctttttcgta ttcgtattcc atgcgcagca
     8161 aaacttgttg ctgctggagg tgaataatag gactatttga atcttgttcc ttcatggttg
     8221 caaaggtaat cattcttcgc ttccgacgga aaaaatgctt tattttgtta aactattcag
     8281 cctttttatt tgtttatgat attaatttgt aatctttaca ataatgaaaa actaaaaaat
     8341 agtggttatg gtatatgatt taacgatgct caaaacgttt tatgctgctt attcggagaa
     8401 gatagaacgc gtacggaacg tactgcggcg tccgatgact ttagcggaga aaattttgta
     8461 tgctcatttg tatgatgggg ataaagtgaa gaactacaga cggggagaag actatgtgaa
     8521 tttccgtccc gaccgtgtgg ccatgcagga tgcaacggct caaatggcct tattgcaatt
     8581 tatgaatgca ggccgtgagc aggttgccgt gccttccact gtgcattgtg accatttgat
     8641 tcaagcatat aaaggtgcaa aagaagatgt tgcgactgct acgaagacca acgaggaggt
     8701 ctataatttt ctccgtgatg tttcttcccg ctatggcata ggtttttggc agccgggagc
     8761 aggtattatt caccaggtgg tattggagaa ctacgcattt ccgggtggaa tgatggtagg
     8821 cacggactct catacgccca atgccggagg tttgggcatg gtggccattg gtgtgggtgg
     8881 tgccgatgcg gtggatgtga tgaccggcat ggaatgggaa ctgaaaaagc cgcgtctgat
     8941 aggcgtacac ttgaagggta aattgagtgg ctgggtagct cccaaagacg ttattctgaa
     9001 gttggcgggt attcttactg taaaaggggg aaccaatgcc atcattgaat attttggacc
     9061 gggaaccgct tcattgtctg ccactggaaa ggctaccatc tgcaatatgg gggcagaggt
     9121 gggggcgact acctcccttt tcccttacga
//
