LOCUS       c00016_gnlPro..        13700 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|MMLGHMIM_16.
ACCESSION   c00016_gnlPro..
VERSION     c00016_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-05 01:53:52
            Original ID  :: gnl|Prokka|MMLGHMIM_16
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13700
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13700
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[210:3700]"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      211..3700
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
     cand_cluster    1..13700
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /kind="single"
                     /product="Fumarate2succinate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..13700
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Fumarate2succinate"
                     /region_number="1"
                     /rules="(Succ_DH_flav_C and FAD_binding_2 and (Fer2_3 or
                     Fer4_7 or SucD_FumR))"
                     /tool="gutsmash"
     CDS             complement(211..1041)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Fer2_3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_8"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052:Succinate dehydrogenase-2Fe-2S iron-sulfur
                     cluster binding domain (Score: -1.6; E-value: 9.2)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg16_1"
                     /sec_met_domain="Fer2_3 (E-value: 2.5e-23, bitscore: 74.1,
                     seeds: 38, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_8 (E-value: 8.2e-11, bitscore: 34.2,
                     seeds: 153, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 4.5e-06, bitscore: 19.0,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LPSAATSKDSQYINTQKKDYNMAKTLNLTLKVWRQENREAKGRIE
                     TYAAKDIPVDASFLEMLDIVNEGLVKEGKEPIHFDHDCREGICGMCSLTINGIPHGPER
                     QVTTCQLHMRKFKDGDTVWIEPFRAKAFPILRDLMVDRSALDRIIAAGGYIDVRTGSAP
                     NANNIAVEKVKADAAFDAAACIGCGACVASCKNASAMLFTSAKIAHLNLLPQGQPERSK
                     RVLAMMKQMEAEGFGNCTNQYECEAACPKGISVDNIARLNRDFMRANAKEGLCF"
     CDS             complement(1019..2977)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: FAD_binding_2"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Succ_DH_flav_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1027:FAD binding domain (Score: 176.1; E-value:
                     4.2e-54)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg16_2"
                     /sec_met_domain="FAD_binding_2 (E-value: 3.9e-54, bitscore:
                     176.1, seeds: 62, tool: rule-based-clusters)"
                     /sec_met_domain="Succ_DH_flav_C (E-value: 1.1e-37,
                     bitscore: 120.8, seeds: 739, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINFPVSDWMPDAKIPSGPIQDKWSKYKLESKLINPNNKRKYTVL
                     VVGSGLAGASAAATLAELGYNVKCFCYQDSPRRAHSIAAQGGINAAKNYQNDGDSVYRL
                     FYDTVKGGDFRAREANVYRLAEVSSNIIDQCVAQGVPFGREYGGLLDNRSFGGAQLKRT
                     FYARGQTGQQLLLGAYQALEKEVAKGHIEMFSRHEMMDLVLVDGEAKGIVTRNLVTGEI
                     KSYAGDTVLLCTGGYGNVFFLSTNAMGCNVTAAYKAYKRGAFFANPCFTQIHPTCIPVK
                     GDYQSKLTLMSESLRNSGRIWVPKSRETAEKIRKKEIKPSDVPEEERDYYLERKYPSFG
                     NLAPRDISSRAAKEACDDGRGVAVTGKGVFLDFADEIKRMGREWIDGQYGNLFDMYEEI
                     TDDDPHETPMMIYPASHYTMGGLWVDYNLMSNVKGLHVLGEANFSDHGANRLGASALMQ
                     GLSDGYFVIPATLPAYLTTTKPGAVTTAAPEFKAAEDEVKERINKLLNVKGTKTVDSFH
                     RELGLIMWEDCGMARTEESLTHAIERIPQLRKEFWENVRVTGTADGINAELEKACRVAD
                     FLEFAQLLCYDALNRQESCGAHFRVEYQLPDGEAKRNDDEYAYVAAWEYTGVDSLPVLH
                     KEPLTFENVHLAIRSYK"
     CDS             complement(2999..3700)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: SucD_FumR"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg16_3"
                     /sec_met_domain="SucD_FumR (E-value: 2.4e-13, bitscore:
                     42.0, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNALVKTICTFVTSSIGRKIIVALTGLCLVLFLAGHLAGNLLIFG
                     GPEWINTYAHGLHSMPEAALWGIRAGLAVIFIIHVWLTIQLKLENHAAREPYVFKNTIK
                     ATLSSRYMIYTGLTVLVFLIYHLYQYTLRVGYDPAQFTTFISDGTVETFDVYKMIVTGF
                     SNVWCSAFYILAVLMLFSHLRHGVQSIFQTVGVDSRKIRPFYNFIAIAYGAIICLGFIS
                     VPVSVLLGIIK"
     CDS             3901..4173
                     /locus_tag="ctg16_4"
                     /transl_table=11
                     /translation="MKRSKKEVLDADFAAARAGVLDVAAFLDRVDRGEGEADFRYHALM
                     DVLPLLSASGPGRVRAILEALSYRDDTVPETAAAKAACGAPNLSK"
     CDS             4176..4991
                     /locus_tag="ctg16_5"
                     /transl_table=11
                     /translation="MMAFIEPHIHMVCRTTDEYRAMAQAGCLAVGEPAFWAGYDRSSAD
                     GFRDYFVQLTECEPARAAKFGMDHYTWLCINPKEAQDVAFARDVMKLIPEFIDRPNVLG
                     IGEIGLNRNTSHEMTIFEEHLDLAVRLNQLVLIHTPHLEDKLKGTVMILSALKNRPDLD
                     PCRVLVDHCEEHTFPLVKEAGYWAGLTLYPTSKLNPKRAADILELYGMDRVWANSAADW
                     GDSDPLALTALACELRRRGFSRQETERLLLENPETFMGQSPKFRKVSSR"
     CDS             complement(5025..5432)
                     /locus_tag="ctg16_6"
                     /transl_table=11
                     /translation="MQSPASLSIRNSPSFQQSISPHGPDRCGSVRRQQTPSPKQGKGVG
                     KWLSLNLYPPFPSMNLQKQQLLLRLFRYFKSRKGEPRFFNKRNICLLAAAGAYILTPDE
                     FLFDGIGRLGLLDDAAVILGAVLTVFFPDGD"
     CDS             complement(5687..6394)
                     /locus_tag="ctg16_7"
                     /transl_table=11
                     /translation="MKKLLSTLILSAGMSLSATANTTLLDSSIVGYSDFTSQTADFGTL
                     KDSVSITSDDSNLTLSGITFNGYGTNNRDVMSVTMVLDLSKINTPETYTALFNAKNSSV
                     SWGVGLNTDRKLQGLWNNTSYSGPVVDTPLGMEGSLTISVVTGDLGTRIYFGDSATYYS
                     NSGLKFGNQQIDQILMDAGLAESIEQLYIHDSLLSQEQVGQLMSEIASIPEPATASLGL
                     LGLAALMMRRRRA"
     CDS             complement(6425..6514)
                     /locus_tag="ctg16_8"
                     /transl_table=11
                     /translation="MNYKYNILTLNIFNCLRIPNSLFKRKCIH"
     CDS             6689..7429
                     /locus_tag="ctg16_9"
                     /transl_table=11
                     /translation="MKKTLTFLIAMGSFAVSSEAATVFNYYTPGTDNYNSTIHGFYLGL
                     GSSSLAPSDSSSPSSLSGEIRLDSFTLRGAANNLGANVTYGFLVLNGSDNSVIGWSTNT
                     GTTAAGINLTFSFSSLDGSPLLLDAALTYRFLAVSQSVMDLMQDTSKTYLYAAGGTAAP
                     TANTEGDTVTISGGLTAPGIRGHYDAEGAPGDSVVITGANGTNTFSLLSPIFTEIRGEM
                     VPEPATVSLGLLGLAALMMRRLRA"
     CDS             complement(7647..7781)
                     /locus_tag="ctg16_10"
                     /transl_table=11
                     /translation="MYAAALQVCELQRGSLSGLKGHYVKAAVYHMDEKRAAEFDGISR"
     CDS             complement(7893..8093)
                     /locus_tag="ctg16_11"
                     /transl_table=11
                     /translation="MTIALRTEQSSDHAETEHVTREAFWNYFVPGCHEHYLLHIMRVSP
                     SFIPELDAVAVHGSRIVGKHR"
     CDS             complement(8107..9312)
                     /locus_tag="ctg16_12"
                     /transl_table=11
                     /translation="MRGIFLVSCFLGGSALLAGCREENNSPRPATEDAARITSARQWGE
                     SRSALQKRELDRAAGPALPIPDDLPSRELVGTTRQIHQLIEASGNPARFESYTETVPVA
                     EASLRMVAIPGGTFLMGSPAEEPHRKPDEGPQHKVSISPFWISETEIPWELYTAFMENG
                     RPRAKDGQLLEEQPDDELWDSVTQPTAPYTAMNLGMGHGYEHGLPAISMSHHAASKFCE
                     WLSAQTGHYYRLPTEAEWEYACRAGSPGAYSYGNGEASLDQYAWYWNNSNDRYQKTGSK
                     KPNKWGLRDMHGNVAEWVLDSYVPDAYGKRSGLPAKDPLVIIPSAPHIVRGGSWEDDPD
                     SLRSAARRASTPAWNRQDPQNPKSIWYLTDGGMIGFRVVRPMNIPDIMTMHRLWNFSKG
                     EP"
     CDS             complement(9336..10265)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short_C2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg16_13"
                     /sec_met_domain="adh_short_C2 (E-value: 4.8e-75, bitscore:
                     244.0, seeds: 358, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKTGRPPVHSGKMKRPDSSPPPRFSPLFFHSRHAPSPYGFLRGQV
                     HFKLAGTVKNGFTVGSMQKLAGKTAIVTGAGRGIGNAVARRFASEGARVILISRSPSSC
                     GGAAEEINKEFPDSCKAYPCDVADYAAVQETMAAILKDFPQIDILVNNAGITRDSLMLR
                     MKEEDWDAVLDTNLKSAFNTVKALQRVLMKSPAGRIINMSSVIGLVGNIGQANYAASKA
                     GLIGFTKSLAQEFAPRKVTCNAIAPGFISTEMSNAIPDNLKEEIVKKIPLKEQGSVEDI
                     AALTAFLASDDARYITGQVIACDGGMTM"
     CDS             complement(10210..10728)
                     /locus_tag="ctg16_14"
                     /transl_table=11
                     /translation="MKAFLVPLLYSALLSGASLAFGETAAGTASPAAAAPAEKIPSAES
                     LINQAFSFAINIQQTLAGVQDKESVDNAVKTLQDIQKDIRHFLQLQDKLNDAEKEKEDA
                     LIEKMEKRMEMLDNRCRQEGKRLFEARYYGSAALKDILENSDEFSDLVEPDEDGAPPGA
                     LRENEEAGQ"
     CDS             complement(10792..12402)
                     /locus_tag="ctg16_15"
                     /transl_table=11
                     /translation="MLTIKNLTKSHAGRTLFRETEMTINWGERVALVGPNGAGKSTLFR
                     MILGEDTPDEGSISMDEYAIVGYLPQEASEPKDETVLEIALGITPEMEQAIHTIRTAEN
                     ANKTDTPEYAEAIDTFNAANGYQLEPKAKKILKGLAFRESDFHRPAREMSGGWIMRAYL
                     AKLLVLEPDLLMLDEPTNHLDLLSLLWLQRYLKNYPGAILMISHDRDFMDELVESVYDI
                     DNEELVEYRGNYSDFLQQKDVRFEQLQAAYRNQQKEIAHIQEFIDRFRSINSKAGQVQS
                     RIKQLEKMKIIQKPVARRKVFKFNFPQPPRSTQKVIELEKVCQSYGDRRVYENLDLLVE
                     RGERTVLVGPNGAGKSTLLKILAGIIPIDSGQRTPGTTTRIGYFSQARTENLNPENTVL
                     EEIMKCSAEIREEEARSILGSFLFRRLDVEKRVSVLSGGEKSRLSLVKFLVDPPNLLLM
                     DEPTTHLDLLSVEALVQALKHYEGTLVFISHDVHFIRSLAQKTLHVNRGTITAYAGGYD
                     YYLEKSGILDDEKGGITAE"
     CDS             12642..13232
                     /locus_tag="ctg16_16"
                     /transl_table=11
                     /translation="MSGLANAFLALLPPDQASLPAAGAEARWLADTAVVQSAAIARDNR
                     TVLFGWLNNILVNSNLRDRGLCWQVQQDLYRDLRRRPVKYFRIGLTIRDRGTGREHSCV
                     YVNAVGKGLQGSIVLDAWKNCGHLVTLTQKDREGGKWEEDWREPFVSKAFPEGHSYGME
                     HHLVWPGWARKRPMLVQRIFQSDQQNEAKAAAE"
ORIGIN
        1 gggcctgctt aggtttcgtc cggcatttcc aagtacggtt tcctggatta ctgggtgcct
       61 tccggtgtaa caatttttta cgctgcgcga cgatgaggaa gcaactgtct ggtattttat
      121 tcctggttca aggaaatctg gtaatgaaaa aactcccgac agccgatgcc gccgggagtt
      181 tttacagagc gtcttaagaa ggaatcttct ttagaaacag aggccttcct tggcgttggc
      241 ccgcatgaag tcgcggttga ggcgggcgat gttgtccacg ctgatgcctt tcgggcaggc
      301 ggcttcacat tcatactggt tcgtgcagtt gccaaagcct tccgcttcca tctgcttcat
      361 catggccagg acgcgcttgg aacgttccgg ctggccctgc ggcagcagat tgagatgggc
      421 gatcttggcg gaggtgaaca gcatggcgga agcgttttta caggaggcca cgcaggcgcc
      481 gcagccgatg caggcggccg cgtcaaaggc ggcgtccgcc ttcacttttt ccacggcgat
      541 gttgttggcg ttcggcgcgg aaccggtacg cacgtcaata tagcctccgg cggcgatgat
      601 gcggtccagg gcggagcggt ccaccatcag gtcccgcagg attgggaaag ccttcgcgcg
      661 gaagggttca atccagacgg tatcgccgtc cttgaacttg cgcatgtgaa gctggcaagt
      721 ggtcacctgg cgttccggcc cgtggggaat gccgttgatg gtcagggagc acatgccgca
      781 gatgccttcc cggcagtcgt ggtcaaaatg gatgggttcc ttgccttcct tgaccaggcc
      841 ttcattgacg atgtccagca tttccaggaa ggaggcgtcc accggaatgt ccttggcggc
      901 ataggtctca atgcggccct tggcttcccg gttttcctgg cgccagacct tgagagtgag
      961 attgagtgtt ttagccatgt tataatcttt cttttgagtg ttaatgtatt ggctatcttt
     1021 acttgtagct gcggatggca aggtgcacgt tctcgaaggt cagcggttcc ttgtggagaa
     1081 caggcaggct gtccacgcca gtgtattccc aggcggctac ataggcgtat tcatcgtcgt
     1141 tgcgcttggc ttcgccgtcc ggcagctggt attccacgcg gaagtgggcg ccgcaggatt
     1201 cctggcggtt cagggcgtca tagcagagca gctgggcgaa ttccaggaag tcggccacgc
     1261 ggcaggcttt ttccagttcc gcgttgatgc cgtccgccgt gccggttacg cgcacgtttt
     1321 cccagaattc cttgcggagc tggggaatgc gttcaatggc gtgggtcagg ctttcttccg
     1381 tgcgggccat gccgcagtct tcccacatga tgaggcccag ttcccggtgg aaggagtcca
     1441 ccgtcttggt gcccttcaca ttcaggagct tgttgatgcg ttccttcact tcgtcttccg
     1501 cagccttgaa ttccggggcg gcggtggtga cggcgccggg cttggtggtc gtcaggtaag
     1561 cgggcaacgt ggcgggaatg acgaagtagc cgtcagacag gccctgcatc agggcggagg
     1621 ctcccaggcg gttggcgccg tggtcggaga agttggcttc accgaggacg tgcagcccct
     1681 tcacgttgga catgaggttg tagtccaccc acaggccgcc catggtgtag tgggaggcgg
     1741 ggtagatcat catgggcgtt tcatgggggt cgtcgtccgt gatttcttcg tacatgtcaa
     1801 acagattgcc gtattggccg tcaatccatt cgcggcccat gcgcttgatt tcatccgcaa
     1861 aatccaggaa gacgcccttg ccggtgacgg ccacgccgcg gccgtcgtcg caggcttcct
     1921 tggcggcgcg ggaggaaatg tcgcgcggag ccaggttgcc gaaggaggga tacttgcgtt
     1981 ccaggtagta gtcccgttct tcttcgggaa catcggaagg cttgatttcc tttttacgga
     2041 ttttttctgc ggtttcacgg gacttgggca cccagatgcg gccactgttg cggagggatt
     2101 ccgacatcag cgtcagtttg gactggtagt cgcccttgac cggaatgcag gtggggtgga
     2161 tttgcgtgaa gcaggggttg gcgaagaagg caccgcgctt gtaggccttg taggcggcag
     2221 tgacgttgca gcccatcgcg ttggtggaca ggaagaacac gttgccgtag ccgcccgtgc
     2281 agagcaggac ggtatcccct gcgtaggatt tgatttcgcc ggtaaccaga ttgcgggtga
     2341 cgatgccctt ggcttcgccg tccaccagca ccagatccat catttcatgg cgggagaaca
     2401 tttcaatgtg tcccttggcc acttcctttt ccagggcctg gtaggcaccc agcaggagct
     2461 gctggcccgt ctgtccgcgt gcgtagaagg ttcgcttgag ctgggcgccg ccgaaggagc
     2521 ggttgtccag caggccgccg tattcacggc cgaagggaac gccctgggcc acacactggt
     2581 caatgatgtt ggaggagact tccgccagac ggtagacatt ggcttcacgg gcgcggaagt
     2641 cgccgccttt aacggtgtcg taaaacaggc ggtaaacgga gtcgccgtcg ttctggtagt
     2701 tcttggctgc gttaatgccg ccctgggccg caatggagtg ggcgcggcgg gggctgtcct
     2761 ggtagcagaa gcatttgacg ttgtagccaa gttcggcaag cgtggcggca gcggaggcgc
     2821 cagccaggcc ggaacctacc acaagcaccg tgtacttgcg cttgttgttc ggattgatca
     2881 gtttggactc aagtttgtac ttggaccatt tgtcctgaat agggccggag ggaattttgg
     2941 catccggcat ccagtcgctt acgggaaaat taatcatgac tttgagagga gttgatggtt
     3001 atttgatgat acccagaaga accgagaccg gcacggagat gaagcccagg cagataatcg
     3061 cgccgtaggc gatggcgata aagttgtaga agggccggat tttgcgggaa tcgacgccca
     3121 cagtctggaa gatggactgt accccgtggc gtagatggct gaacagcatc agaacggcca
     3181 ggatgtagaa ggcggagcac catacgttgg agaatccggt cacgatcatc ttgtacacgt
     3241 caaaggtttc caccgtaccg tcggaaataa aggtggtgaa ctgggcgggg tcgtatccca
     3301 cgcgcagggt gtactggtac aggtggtaga tcaggaacac caggacggtc aaaccggtat
     3361 agatcatgta gcgggaggag agcgttgcct taatggtgtt cttgaacacg tagggttcgc
     3421 gggccgcatg gttttccagc ttcagctgga tggtcagcca gacgtggatg atgaagatca
     3481 ccgcaagccc cgcgcggatt ccccagaggg ctgcttccgg catggagtgc aggccgtggg
     3541 cgtaggtgtt gatccattca gggcctccga agatgagaag gttgcctgcc aggtgtcccg
     3601 caaggaacaa gaccaaacat aaccccgtca gagccacaat gattttgcgg ccgatggagg
     3661 atgtcacgaa tgtacatatg gtttttacta gtgcattcat aggcgctcta atgaaataaa
     3721 tgcgtcttca caggatgccc ggttcaagcc cggatggcaa gcctcttctt gaatttccgg
     3781 cgcttttcgg atttttgaaa aaccggggaa agaggttgct gtttatcagt ttggaatggt
     3841 tatcattttg ttgcctgttc cggcttgacg aggctttccg cataggcgta tcgtctgtgc
     3901 atgaaaagaa gtaaaaagga ggtgctggac gcggatttcg cagcggcgcg cgccggcgtt
     3961 ctggatgtgg ccgcatttct ggaccgggtg gaccgcgggg aaggggaggc ggatttccgc
     4021 taccatgccc tgatggatgt tcttcccctc ttgtccgcat ccggccccgg acgcgtccgg
     4081 gccattctgg aagccctttc ctacagggat gacaccgtgc cggaaaccgc cgcagccaaa
     4141 gcggcctgcg gagccccgaa cctcagcaaa taagaatgat ggctttcata gaacctcata
     4201 tacatatggt gtgccgcacc acggacgaat accgggccat ggcgcaggcc ggctgcctgg
     4261 cggtagggga accggcgttc tgggccggtt acgaccgttc gtccgcggac ggtttccggg
     4321 attatttcgt acagcttacg gaatgcgaac ccgccagggc ggccaagttc ggcatggacc
     4381 attacacatg gctgtgcatc aatcccaagg aggcgcagga cgtggctttc gcgcgggatg
     4441 tgatgaaact gattccggag ttcattgacc ggcccaatgt cctcggcatc ggggaaatag
     4501 ggctgaaccg gaatacttcc catgaaatga ctatttttga agagcatctg gatctggcgg
     4561 tgcgcctcaa ccagcttgtg ctgattcaca ctccccatct ggaagacaag cttaagggga
     4621 ccgtaatgat tctttccgcc ctgaaaaacc gtccggatct ggacccttgc cgcgtgctgg
     4681 tggatcactg tgaggaacat accttcccgc tggtgaagga ggccggttac tgggccgggc
     4741 tgacccttta tcccaccagt aagctgaatc ccaagcgggc ggcggatatt ctggaattgt
     4801 acggaatgga ccgtgtctgg gccaattccg cggcggactg gggggattcc gatcccctgg
     4861 cgctgacggc cctggcctgc gagctgcgca ggcgcggttt ttcccggcag gaaacggaac
     4921 gtcttctcct ggaaaatccg gagacattca tgggacagtc cccgaagttc cggaaagtgt
     4981 cgtcccgcta attccgcccg aggcgcggcg gagggtacgg ccctctagtc cccgtccggg
     5041 aaaaagacgg tgaggacggc gcccaggatg accgccgcgt catccagaag gcccagcctg
     5101 ccgattccgt caaacaggaa ttcgtcggga gtcaggatgt aggcgccggc ggcggccaga
     5161 aggcatatat tccgtttgtt gaaaaaacgc ggttctcctt ttctgctttt gaaataccgg
     5221 aacaggcgca gtagcagctg ctgtttttga aggttcatgg acgggaacgg gggataaagg
     5281 ttcaagctca gccattttcc cactcctttt ccctgtttcg gggaaggagt ctgttgccga
     5341 cggacggaac cgcagcgatc cggaccgtgc ggggaaatgg attgctgaaa ggatgggctg
     5401 ttccggatgc tgagggaagc cgggctttgc atgctccggt tccggctgtc ccggcatggg
     5461 aaaaaggggc gtgtacggaa gtggggcggg gccggaagct cttgaaatga ccctaccggg
     5521 ggagactgaa tgctattttt ccgtcaagtg ctggccgtga ggttgccgca gcaaatggaa
     5581 gcttttcccc tctgtttttt cggcagatgt ttgaacggat aaggaaaagg ccggctcacg
     5641 attttgtgag ccggcctttg aatataggga ggcggacggt acaggcttat gccctgcggc
     5701 ggcgcatcat cagcgcggcc agtcccagca ggcccaggga agccgtggcg ggttccggaa
     5761 tgctggcgat ttcactcatc agttgaccaa cttgttcctg ggaaaggagg gagtcgtgga
     5821 tgtagagctg ttcgatggat tcagccagtc ctgcgtccat gagaatctga tcaatttgct
     5881 ggttgccgaa tttcaggccg ctgttggaat agtacgtagc gctgtcgcca aaatagatgc
     5941 gggtgccaag atctccggtg actacggaaa tggtcaggga cccttccatg cccagcgggg
     6001 tgtcaacgac gggcccgctg tatgaggtgt tgttccataa tccctggagt ttccggtccg
     6061 tgttcaggcc cacgccccag cttacactgc tgtttttggc gttaaacaga gcggtatagg
     6121 tctccggagt gttgattttg gacagatcaa gaaccattgt cacagacata acgtcgcggt
     6181 tgttggtacc gtatccgttg aaggttatcc cggataacgt cagattgctg tcgtcagacg
     6241 tgatggaaac ggaatctttc agggtgccga aatccgccgt ttgggaggta aagtccgaat
     6301 atcccacgat agagctatcc agcagagtgg tattcgcggt ggcgctcagg ctcatgccgg
     6361 ccgaaagaat cagggtggat aataatttct tcatggtcag tatcttaata aaatgatgca
     6421 agattcaatg tatgcacttg cgcttgaata acgaatttgg aatccgcaag caattaaaaa
     6481 tattaagagt tagtatattg tatttataat tcattgaaaa taatgatttt ttaatatctc
     6541 tggtcctttt gtcaagatga cggggcaatc tttgttattc attggtttca tgattgattt
     6601 ggcctctttt tcattacttg acggattcca aatccgattg gggaattcca aattcgctac
     6661 aagttgccat ccaaaaggaa taataaatat gaagaaaaca ctgacatttt taatcgcgat
     6721 gggaagcttt gctgtttcct cggaggcagc gaccgttttt aattattaca ctcccggtac
     6781 ggataattac aatagtacca tccatgggtt ttatcttggc ctggggtctt cttccctggc
     6841 tccttccgat tcctcttctc cctcctccct gtccggagag atcagactgg acagttttac
     6901 gctgcgcgga gccgccaaca atttgggcgc taatgtcact tacggcttcc tggtgctgaa
     6961 tggctccgac aattcggtca tcggctggag caccaatacg ggaactactg cagcagggat
     7021 taatctgacg ttcagttttt cttccctgga tggttctccc ctgcttcttg acgcggcatt
     7081 gacataccgt ttcctggccg tgagccagtc cgtgatggac ttgatgcagg atacgtctaa
     7141 aacgtattta tatgctgcgg ggggaacagc cgcccctact gctaacacgg aaggagatac
     7201 cgtaacgatc agcggcggat tgactgctcc cggcatccgc ggccattatg acgccgaggg
     7261 agcgcctggt gattctgtcg ttattacggg agccaacgga accaatactt tcagcttatt
     7321 atccccgatt ttcacggaaa tccgagggga aatggtgccg gaaccagcca cggtttccct
     7381 gggcctgctg ggactggccg cgctgatgat gcgccgcctc agggcttgag cttcctgatg
     7441 gcgaaaaatc ggcggatgag agctgttctt gcggaacagc tcttgttttt tatatccaga
     7501 gaggaagaat tgcttatccg tatgcgggat tcatgccctc cggaaggtac ggaatttccg
     7561 ggggcagggg gccgtatccg gttttttcgg catggcggca atttgctgga aacgtttttg
     7621 agacgcagta ccggaaagct ttttctttac cgggaaatgc cgtcaaattc ggcagcgcgc
     7681 ttttcgtcca tatggtacac ggcagctttc acatagtggc ctttcaggcc ggatagggaa
     7741 cccctttgca gctcacagac ctggagggcc gccgcataca tattattcgc cgtcctattc
     7801 cccggcgctg gtatttcgga agaacggcaa tgggccccat gcccagcact tcatattctt
     7861 ttccatcgtc tgccctgatg acggacgttg catcaacgat gtttcccgac gatgcggctg
     7921 ccgtggacgg cgactgcatc cagctccggg atgaaggacg gactgacgcg catgatatgg
     7981 agcaggtaat gttcatggca gccggggacg aaatagttcc agaacgcttc tctcgtgaca
     8041 tgttccgttt cggcatggtc tgaggattgt tccgttctta atgcaatggt catgaaaggt
     8101 tgttctttac ggctccccct tggagaaatt ccagaggcgg tgcatcgtca taatgtccgg
     8161 aatgttcatg gggcgcacca cgcggaaccc gatcatgcct ccgtccgtca ggtaccagat
     8221 gcttttaggg ttttgaggat cctgacggtt ccaggcgggg gtgctggcgc ggcgcgcagc
     8281 gcttctcagg ctgtccgggt cgtcttccca cgaaccgccg cgaacgatgt gaggggcgct
     8341 ggggatgatg accaaggggt ctttcgcggg caagccgctc cgtttgccgt aggcatccgg
     8401 aacgtaagag tccaaaaccc attccgccac atttccgtgc atgtcccgga gtccccactt
     8461 atttggtttt ttagagcctg ttttctggta gcggtcattg gagttgttcc agtaccaggc
     8521 gtactggtcc agagaggctt ccccgtttcc gtaagaatag gcgccggggg agccggcccg
     8581 gcaggcgtat tcccattccg cctccgtggg caggcggtag taatgcccgg tctgggcgct
     8641 cagccattcg cagaatttgc tggcggcgtg gtgggacatg gagatggcgg gcagaccgtg
     8701 ttcatagccg tggcccatgc ccaggttcat ggcggtgtag ggggcggtag gctgcgtaac
     8761 ggagtcccac agttcgtcat ccggctgttc ctccagaagc tggccgtcct tggcgcgcgg
     8821 acgcccgttt tccatgaagg ccgtataaag ttcccagggg atttccgttt ccgagatcca
     8881 gaagggggag atgctcactt tatgctgcgg accttcgtcc ggtttccggt gcggctcttc
     8941 cgcgggactc cccatgagga acgttcctcc cggtatggcg accatgcgca gggaagcttc
     9001 cgccacggga accgtttccg tgtaggattc aaaacgtgcc ggatttccgg aagcttcaat
     9061 gagctgatgg atttggcgcg ttgtgccgac cagctcccgg gacggcaggt catccggaat
     9121 gggaagggca ggaccggcag cgcggtccag ttcccgtttt tgcagcgcgg atcggctttc
     9181 tccccactgg cgtgcgctgg taatgcgcgc ggcatcttcc gtggccgggc ggggggaatt
     9241 attttcttcc cggcacccgg ccagcagggc gcttcctccc agaaagcagg aaacaaggaa
     9301 aatgccgcgc atggaatgga gaaaaccgga atgccctaca tcgtcatgcc tccgtcgcag
     9361 gcaatgacct gcccggtgat gtaacgggca tcgtcagagg caaggaaggc cgtcagggcg
     9421 gcgatatctt ccacggaacc ttgttctttc aaaggtattt tcttaacgat ttcttccttg
     9481 agattgtcgg gaatggcatt ggacatttcc gtggagatga agccgggagc aatggcgttg
     9541 cacgtgactt tgcgcggagc gaattcctga gccagtgatt tggtgaaacc gatgaggccc
     9601 gccttggaag cggcgtaatt ggcctgaccg atgttgccga cgagaccgat gacggagctc
     9661 atgttgatga tgcgcccggc cggggatttc atgagaacgc gctggagggc cttgaccgta
     9721 ttgaacgcgc ttttcaggtt ggtgtccaga acggcatccc agtcttcctc tttcatgcgg
     9781 agcatcaggg agtcccgcgt gatgccggcg ttgttcacca ggatgtcaat ctgcgggaag
     9841 tctttcaaaa tggcggccat ggtttcctga acggccgcgt aatccgctac gtcgcagggg
     9901 taggccttgc aggaatccgg aaattccttg ttgatttctt ctgcggcccc cccgcagctg
     9961 gatggactgc ggctgatcag gatgaccctg gctccttccg aagcgaagcg gcgcgcgacg
    10021 gcattgccga ttccgcggcc cgcgccggta acgatggctg ttttacctgc taacttttgc
    10081 atgctgccca cagtaaaccc gtttttcacg gttccggcaa gcttgaaatg gacttggccg
    10141 cgcaggaacc catacgggga aggggcgtgc cgggaatgaa aaaagagggg ggagaaacgg
    10201 ggcggggggc tactgtccgg cctcttcatt ttcccggagt gcaccggggg gcgccccgtc
    10261 ttcatccggt tctaccaggt cgctgaattc atccgaattt tccaaaatgt cctttaaggc
    10321 ggcggaaccg taatagcggg cctcaaacag gcgtttgcct tcctgcctgc agcggttgtc
    10381 cagcatttcc attcgttttt ccattttttc tatcaaggcg tcttctttct ccttttccgc
    10441 atcgttcaat ttatcctgaa gctggaggaa atgccggatg tccttctgaa tgtcctgcag
    10501 cgttttgacg gcgttgtcca cgctttcctt gtcctgaacg cctgccaacg tctgctggat
    10561 attgatggca aaggaaaagg cctggttgat cagggattcc gcggaaggaa ttttttccgc
    10621 cggagccgct gctgcggggg aagccgttcc ggcggccgtt tcaccaaatg caagagaggc
    10681 tccggacaga agcgcagaat ataagagagg aacaagaaaa gccttcatcc tgttctttta
    10741 aggcaggatg aaatccacgg caaggaaaaa ggggaaactg aaaaaagagc cttattccgc
    10801 cgtgatgccg cctttttcat cgtccagaat gcctgacttt tccagatagt agtcatatcc
    10861 acctgcgtag gcggtgatgg tcccccggtt cacatgcagg gttttttgtg ccagggaacg
    10921 gatgaagtgc acatcgtggg agatgaagac cagtgttcct tcataatgct tcagagcctg
    10981 caccagggct tctacggaca aaaggtccag gtgggtggtc ggctcgtcca tcagcaggag
    11041 gttgggcgga tccaccagga atttgaccag gctgagccgc gatttttccc cgccggaaag
    11101 aacgctgacg cgtttttcca catccagcct ccggaacagg aaggaaccca ggatggaacg
    11161 cgcttcttcc tcccggattt cagcgctgca tttcatgatt tcctccagca cggtattttc
    11221 cggattcagg ttttccgttc gcgcctggga gaagtagccg atgcgcgtcg tggtaccggg
    11281 agtgcgttgt ccggagtcaa tggggatgat gcccgccagg attttgagaa gagtggattt
    11341 gcccgcgccg ttcgggccta caagaacagt gcgctccccg cgttctacca gcaggtccag
    11401 gttttcataa accctgcggt cgccatagga ttggcagact ttttccagct caatgacttt
    11461 ctgggtgctg cgcggaggct gggggaagtt gaatttaaat actttcctgc gggctaccgg
    11521 tttttgaatg attttcatct tttccagctg cttgatgcgg ctctggactt gcccggcttt
    11581 ggaattgatg gagcggaaac ggtcaataaa ttcctgaatg tgcgctattt ccttctgctg
    11641 gttgcggtag gccgcctgaa gctgctcgaa gcgcacgtcc ttttgttgga ggaagtccga
    11701 gtaattgccg cggtattcca ccagttcttc gttgtcgatg tcgtacacgc tttccaccag
    11761 ctcatccatg aaatcccggt cgtgggaaat catcaggatg gctccggggt agtttttcag
    11821 gtatcgctgg agccacagca gggacaggag gtccaggtgg ttggtaggtt cgtccagcat
    11881 caggaggtcc ggctccagga caaggagctt ggccaggtac gcgcgcatga tccagccgcc
    11941 ggacatttcc cgggcggggc ggtggaagtc gctttcccga aaggccagcc ctttgagaat
    12001 ttttttggct ttgggctcca gctggtaacc gttggcggcg ttgaaggtgt caatggcttc
    12061 cgcgtattcc ggcgtatccg ttttgttggc gttttccgcc gtccggatgg tgtggatggc
    12121 ctgttccatt tccggcgtga tgcccagggc gatttccaga acggtttcat ccttcggttc
    12181 gctggcttcc tggggaagat agcccacgat ggcgtattca tccatgctga tggagccttc
    12241 gtccggcgtg tcttctccca gaatcatgcg gaacagggtg gatttgcctg ctccgttggg
    12301 gccaaccaga gccacccgtt ccccccagtt aatggtcatt tccgtttccc tgaacaaggt
    12361 ccgtccggcg tgggattttg tgagattttt gatcgtcagc atggtgaaga gaggatgtat
    12421 tctaccggga tggaaagggg aaggcaagag ccgtcagggc ggaggcaggc atttttgaaa
    12481 gctttactgg atttttacgc gtagtctgct agccttggcg cgccatgccg accacgcaga
    12541 cattcaggct tttgcttgct gccgcccttt tgtgcggatg gagttcctgc tgtactcctc
    12601 cggcggagga ttatatacaa caaccttacg tgcagcagca aatgtccggg ctggctaatg
    12661 ccttcctggc gctgctgccg ccggatcagg cctctcttcc cgctgccgga gcggaggcca
    12721 ggtggctggc ggacacggcc gtggtccagt ccgcagcgat tgcccgggac aacaggactg
    12781 tgctgtttgg ctggctgaac aatattctgg tcaattccaa cctgcgcgac agggggctgt
    12841 gctggcaggt ccagcaggat ttgtaccggg acctgcgccg ccgccccgtg aagtatttcc
    12901 gcatagggct gacgattcga gaccgtggaa cgggcaggga gcacagttgc gtgtatgtca
    12961 atgccgtggg gaagggattg cagggctcca ttgttctgga tgcctggaag aactgcgggc
    13021 atctggtgac gctgacccag aaggaccggg aaggcggcaa atgggaggag gactggcggg
    13081 aaccatttgt ttccaaggcc tttccggagg gccattccta cggcatggaa catcacctgg
    13141 tctggcccgg gtgggccagg aaacgcccca tgctggttca gcggatattt cagtccgatc
    13201 agcagaatga ggcgaaggcg gccgctgaat aaaggggaag cctgatccgg caggaaccgg
    13261 cacacggtgc tgcgccgcgg cggtttgcgg tatccgccgt ttttaaggaa aatcccggcg
    13321 aatcggcaaa tggcggaggg aatccggact cagggcaaat aaaaacgcac tcagtgcgta
    13381 caccgagtgc ggattaattg gataatttgc tagtgttgca gggcaaaacc ccgctgcaaa
    13441 cttacttgcc cttggcctgc acaaccggag cgggagcagg agcggtggtt tgctgttgct
    13501 gctgctgctg ggagcaagaa gcgaccaggc aagcggcgcc ggcgatggcg aggatagcga
    13561 tgttcttcat aattcgaatt aaatacagtg tttgttaact actggaacct ccgcatccac
    13621 ggaggtttgc tggcaccaat gtaaatggtg gcaagtagaa atcaagagat tttcttgttc
    13681 catgtcacgg cattacagaa
//
