LOCUS       gnlProkkaHNLMBNPC_15   12324 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|HNLMBNPC_15.
ACCESSION   gnlProkkaHNLMBNPC_15
VERSION     gnlProkkaHNLMBNPC_15
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-12-01 18:39:31
            Original ID  :: gnl|Prokka|HNLMBNPC_15
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 12324
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12324
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[3010:7324]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      3011..7324
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..12324
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..12324
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             3..1784
                     /gene_functions="transport (smcogs)
                     SMCOG1186:polysaccharide export protein (Score: 71.6;
                     E-value: 8e-22)"
                     /gene_kind="transport"
                     /locus_tag="ctg15_1"
                     /transl_table=11
                     /translation="MTSDIRLTLGNIRTIQINVMGEVVQPGTYALSSFSTVFHALYRAG
                     GVSDIGSLRNVQLVRNGKNIATIDVYEFIMKGNTQDDIRLQEGDVVIVPAYDVLVKISG
                     KVKRPMRFEMKKDENLATLIKYAGGFEADAYTRSLRVVRQNGEEYEVNTVKDMDYSIYT
                     MRNGDVVTAEAILNRFTNKLEIRGAVYRPGIYQLSGKLNTIRELVHEAQGLTGDAFLNR
                     AVLYRQREDLTSEVVQIDIRSIMDGTSPNLALMKNDILYIPSIHDLEDRGNVTVYGEVA
                     QPDSYPYADNMTLEDLIIQAGGLKEAASTVRIDVSRRIKNPRSTADNDTIGQMYTFSLK
                     DGFVIDGQPGFILQPYDEVYVRRSPGYQAQQNVVIDGEILFGGNYAMTNREERLSDLVN
                     KAGGPTNLAYLRGAKLTRVASAGEKKRMGDVIRLMSRQLGEAMIDSLGIGVEDTFTVGI
                     DLEKALTNPKGSADLVLREGDVVFIPKNTNTVTINGAVMVPNTVSYMKGKNVDYYLNQA
                     GGYSDNARKSKKFIVYMNGQVTKVKGSGKKQIEPGCEIIVPGKAKKKGNIANILGYATS
                     FSSLGMMIASIANLIKK"
     CDS             1799..2947
                     /locus_tag="ctg15_2"
                     /transl_table=11
                     /translation="MSEQRQDKNLLSEPHKTESDEIEIDLVDIFRKIIAIRKKLYKAVG
                     IGFIIGIIVAVSIPKQYTVKVTLSPEMGNAKGSNGLAGLAASFLGDGALIGESTDALNA
                     SLSADIVSSTPFLLELLEMEVSVSKKDDKMTLGSYLDEESSPWWDYLIGFPGIVIGGVK
                     SLFGEDTVPASGGRQGTIELTKEVNEKINFLKKKISASIDKKTAITSITVTLQNPQITA
                     VIADSVVHKLQEYIIGYRTSKVKEDCAYLERLFKERQQEYYAAQRKYADYVDAHDNVVL
                     QSVRAEQERLQNDMSLAYQIYSQVANQLQVSRAKVQEEKPVFAVVEPAVVPLKPSGMGL
                     KIYILLFVFLSVSGTLVWVFFGKSLLASLRKELKNKEIEQDK"
     CDS             3011..3730
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064:glucose-1-phosphate
                     adenylyl/thymidylyltransferase (Score: 56.8; E-value:
                     3.1e-17)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg15_3"
                     /sec_met_domain="NTP_transf_3 (E-value: 4.2e-16, bitscore:
                     52.9, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRTAMIMAAGMGTRFGQYTELIPKGFVKVGGIPMIVRSIDTLLS
                     CGIERIVIGTGYKQEVYEELKTDYPMLETCFSPRYAETNSMYTLYNTREILGNDDFLLL
                     ESDLIFEKQAIMSLLECPAADAMLIAPVTKFQDQYYVEHDDNFRLSSCSVNKNKLNAKG
                     ELVGIHKLSGSFYKIMCADYASIVDEQPNLGYEYELLRISCSQSPVYVHKVEGLKWYEI
                     DDISDLEYAEKYIVPYC"
     CDS             3751..5052
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 208.9;
                     E-value: 1.5e-63)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg15_4"
                     /sec_met_domain="CTP_transf_like (E-value: 2.2e-12,
                     bitscore: 40.6, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates (E-value: 2.3e-120, bitscore:
                     394.2, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 2.6e-62, bitscore:
                     203.6, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKTVYIGMTADIMHPGLIRIINEATKYGDVIIGLLTDKAIAEHK
                     RLPYLTYEQRKEVVQNIKGVCKVVPQEEWSYVENLKRIKPDYIIHGDDWKTGPLREERV
                     RVFEVMNEQGGKVIEIPYTLGINSSSLDKDIKAIGTTPDVRLKSLRRLINAKPVVRILE
                     AHDGLCGLIIENQEILKGDKREVFDGMWSSSLTDSTSKGKPDIEAVDLTTRLQDLNNIL
                     ECTTKPIIFDGDTGGKIEHFVFTVRTLERHGISAIIIEDKVGLKKNSLFGTDVIQTQDT
                     IEGFCNKIKAGKASQITDDFMIIARIESLIAGKPVSDALERAFAYVQAGADGIMIHSKN
                     KSGEDIKEFCLAFRKQYAHVPIVVVPTTYDHIYESELCDWGVNIIIYANHMLRAAYPAM
                     MNVAKIILENERALEVRELCMPIKEILELIPGTK"
     CDS             5069..6193
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 58.1;
                     E-value: 1.1e-17)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg15_5"
                     /sec_met_domain="TPP_enzyme_N (E-value: 1.2e-19, bitscore:
                     63.7, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.1e-19, bitscore:
                     64.0, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLSVEKVYETFLSHDVDFFTGVPDSLLKNICAYITDHTSREKHII
                     AANEGAAVGIASGYYMASGKVPVVYMQNSGLGNTVNPLLSLADEQVYSFPMLLMIGWRG
                     EPGTKDEPQHKKQGEVTLDLLKAMRIPYIILDSNENDAFIQLHDIIQSAKTKNIPHAII
                     IRKDVFGKYKLQKEFGCNYPLSREDALQIVVDYLPENSVVVSTTGKLSRELFEYREMKE
                     QGHEHDFLTVGSMGHSSSISLGIAIAKQDRPVYCLDGDGAFIMHLGAISNIGDLSPKNY
                     YHILFNNGAHESVGGQPTLGFSLDIPAIVRGSGYKHTYTVCTKVEIEEAMKQLPKLCGP
                     VLLEIKVKIDSRENLGRPTTTPIENKEHFMDFLK"
     CDS             6203..7324
                     /NRPS_PKS="Domain: Aminotran_5 (30-366). E-value: 2.9e-34.
                     Score: 110.4. Matches aSDomain:
                     nrpspksdomains_ctg15_6_Aminotran_5.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139:aminotransferase class V (Score: 76.3; E-value:
                     3.6e-23)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg15_6"
                     /sec_met_domain="Aminotran_5 (E-value: 1.8e-30, bitscore:
                     99.3, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIERKILLNPGPATTTDSVKMAQVVPDICPREKEFAGMMKQLRD
                     DLVRVAHGNLEKHTAVLFCGSGTINIDICLNSLLPEDKRVLIVNNGAYSTRAVEVCQYY
                     GLPHINLEFSVYERPDLSVVENVLQENPDIAMVYTTHHETGTGILNPIREMGAIAHKYQ
                     AKFVVDTTSSLGMIPFDIEKDNVDFCMASAQKGLQAMTGLSFIIGNEEQIKFSKKYPKR
                     SYYCNLYLQYENFERTGEMHFTPPVQTIYATRQALNEYFEVGEEAKFARHKRVFEAIHS
                     GINEIGLKSVIKREWQSGLVVSVQYPEDPNWDFEKIHDYCYERGFTIYPGKISTEDTFR
                     ICALGEIEVDDIENFFKVLKAALNHYNVTLPMS"
     aSDomain        6293..7300
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg15_6_Aminotran_5.1"
                     /evalue="2.90E-34"
                     /label="ctg15_6_Aminotran_5.1"
                     /locus_tag="ctg15_6"
                     /protein_end="366"
                     /protein_start="30"
                     /score="110.4"
                     /tool="antismash"
                     /translation="PREKEFAGMMKQLRDDLVRVAHGNLEKHTAVLFCGSGTINIDICL
                     NSLLPEDKRVLIVNNGAYSTRAVEVCQYYGLPHINLEFSVYERPDLSVVENVLQENPDI
                     AMVYTTHHETGTGILNPIREMGAIAHKYQAKFVVDTTSSLGMIPFDIEKDNVDFCMASA
                     QKGLQAMTGLSFIIGNEEQIKFSKKYPKRSYYCNLYLQYENFERTGEMHFTPPVQTIYA
                     TRQALNEYFEVGEEAKFARHKRVFEAIHSGINEIGLKSVIKREWQSGLVVSVQYPEDPN
                     WDFEKIHDYCYERGFTIYPGKISTEDTFRICALGEIEVDDIENFFKVLKAALNHY"
     CDS             7321..7464
                     /locus_tag="ctg15_7"
                     /transl_table=11
                     /translation="MIAEILLKIRHFYFSLRGIHFHPESVISGVPIRSFRLVGKYGNIN
                     LR"
     CDS             7667..9151
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg15_8"
                     /sec_met_domain="Polysacc_synt (E-value: 1.6e-30, bitscore:
                     99.7, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MENLKQKTVSGIMWSAIERFSLQGVQFIIQIILARLLLPSDYGMI
                     GMLAIFLQVAQVFIDSGFTNALIQKKDRTEEDFATVFYFNILVAVLFYGILFFSASLIA
                     DFYNMPTLVLVIRFIALSLIINALSAIHRTKLIISVNFKTQSKISLGAAFISGVIGIWM
                     AYVGCGVWALVWQTLLNSIILTILFYCLVHWKPLHTFSKSSFERLFNFGSKLLISSLIN
                     TVYRNLYTIVIGKKFSVVELGYYTRAEQFAIFPSNNLNALVSRVAYPILSSIQDDDKCL
                     TNAYRNYIRLSSYIIFPLMVGLLVLANPIISLLLTDKWSGVVILLQILCLDWMFDHLSQ
                     INLNLLWVKGRSDLSLRLEIIKKTIAIFILFVSIPFGLEVMCWGRVIYSLIATYLNTYY
                     TNSLIDLTLKLQVKDVFPSLILSFIMGGIVFICISFFETDIVKIVIGCITGMSFYILLS
                     FLFKLDSFFCILTLIIKTKNIDENIKKDFSSNSKDN"
     CDS             9105..10364
                     /locus_tag="ctg15_9"
                     /transl_table=11
                     /translation="MKILKKIFQVIVKIINHCVPVDSRSLYFIPHPNCRTDKYDIINYS
                     SDNVLVLLNYLLKKDSAEYYKIYVEIYDSSRISEYQEYIYGINPNIRCTFLCACVGRFF
                     FNKVSFKDMLYAFFCFCRASKCFTATFYYDFSFKKRSQQIICLGYYTPFKDDYHMGDHS
                     YDKFRNTTCNSFDYSIATSCLSARIISIDCGISYDKFKVLGFPRNDLLISKNNCNVIKR
                     EISKFAGYDVTKYIVYTPTFRDYETVTEGNLRSILGYVDCDLLKLSKILLKFNAALILK
                     LHPLQNKTVLKKDLPKGILVFEQTYKYGLYDLLSFSDGMITDYTSTYFDFLLVNKPVIF
                     NFYDIEEYRRVRGFSFEPIEFFCAGDIVYNYNELIDAVMGLLAGKDIHAEHRRHISLLM
                     NQFQDDNSTKRICDIFLNEI"
     CDS             10373..11119
                     /locus_tag="ctg15_10"
                     /transl_table=11
                     /translation="MNYAFVVQARLGSTRLPGKILKPFYGNQSILDLMVHKLSAISNIP
                     VIIATTNSVINEPIEKKALALGVKCFRGEENDVLKRFIDVAEYFDIQGIFRICSDNPFL
                     DVHAARQLVEIAMKSCNDYISFDIDGTPSIKTHFGFWGEFVTLDALKRVIGFTDDLLYR
                     EHVTNYIYSHPELFNIQWISGSPVVSKHHNIRLTIDTLEDFSVAQRIYRDLQEKRVEIS
                     IEVIVDYVRRHAEYIQLMKQQIKKKF"
     CDS             11123..12163
                     /locus_tag="ctg15_11"
                     /transl_table=11
                     /translation="MKNTYIIGEIGQNHNGSVDLAKLIIELISRPVHEDVFGMDFMPMN
                     AVKMTKRDLSEELAVSQMNQIYDNPNSFGRTYGEHRAFLELDDQAHFEIYKYAKSLGLD
                     FIETLCAKGCLSLLKLFTPDRLKVASRDLTNLPLLEALAETHIPIILSTGMAGQRELDN
                     ALDVITRYHSNIAILHCVSQYPTHPNNLNLRTITYLKKHYNKFEIGFSDHTIGISAATA
                     AVAMGAEIIEKHVTIDRHMKGTDQLGSLGPDGVNRMIRDIRIAECWLGTEDLYIEKGVE
                     KSKIKLERSIATRKYIPAGSIIQESDIHLLSPGDGYKWIDKKNVIGHFAKQDISANEII
                     YPDFIE"
ORIGIN
        1 accctacttc cgacatccgt ctgactttgg gtaatatccg tactattcag atcaacgtga
       61 tgggagaggt cgtgcagccg ggtacctacg ccctttcttc cttctctacc gtcttccacg
      121 cgctttaccg tgcaggcggc gtgagtgata tcggcagcct ccgaaacgtt cagttggtac
      181 gcaacggaaa gaatatcgcc accatcgatg tttacgaatt tatcatgaaa ggcaacacac
      241 aggatgacat ccgccttcag gaaggtgacg tggttatcgt ccccgcctac gatgtcttgg
      301 taaagatcag cggcaaggta aaacgtccta tgcgttttga aatgaagaaa gacgagaacc
      361 ttgccacttt aatcaaatat gccggcggct ttgaagctga cgcctacacc cgttcattac
      421 gtgttgtccg tcagaatggt gaggaatacg aagtcaacac agtcaaggat atggactaca
      481 gcatctacac aatgcgtaac ggtgacgttg taacagccga agccatcctt aaccgcttca
      541 caaacaaact ggaaatccgt ggcgctgtct atcgtcccgg catctaccag ctcagcggta
      601 aactgaacac gatccgcgaa cttgtccatg aagcccaggg cctgaccggt gacgctttcc
      661 tgaatcgtgc cgtcctttat cgccagcgtg aggatttgac cagtgaagtt gttcagatag
      721 acatcaggtc tatcatggac ggtacttccc cgaacctcgc cctgatgaag aatgacatcc
      781 tttacattcc gagcattcac gatctggaag atcgtggcaa tgttacagtt tacggtgagg
      841 tcgcccaacc ggattcctat ccctatgctg ataacatgac acttgaggat ctgatcatcc
      901 aggccggtgg cttgaaagaa gccgcctcca ctgtccgcat tgatgtgtcg agacgaatca
      961 agaatccccg tagtaccgcg gataatgata ctatcggtca gatgtatacc ttctctttaa
     1021 aggatggttt tgtcatcgac ggtcagcccg gttttatcct tcagccttat gacgaagttt
     1081 atgtccgtcg cagtccgggt tatcaggcac aacagaatgt agtcattgat ggtgaaatcc
     1141 ttttcggagg aaattatgcc atgaccaacc gtgaggaacg tctttccgat ctggtgaata
     1201 aagcgggtgg tcctactaac cttgcctatc ttcgtggtgc gaaattgacc cgtgtggcaa
     1261 gtgccggtga gaagaaacgt atgggtgatg tgattcgcct gatgagcaga caattgggag
     1321 aggccatgat tgactctttg ggtattggtg ttgaggatac ctttacggta ggcattgatc
     1381 tggagaaggc tttgactaat cctaagggta gtgccgacct tgtcctacgt gaaggtgatg
     1441 tggtcttcat accaaagaat actaatactg taactatcaa tggtgctgtc atggttccga
     1501 atacggtttc ttatatgaag ggcaagaatg tggattatta cctgaatcag gccggtggtt
     1561 attctgataa tgcaaggaag agtaagaaat tcattgttta catgaatggt caggtgacga
     1621 aggttaaggg tagtggtaag aaacagattg agccgggatg tgagattatt gtgcctggta
     1681 aggctaagaa gaaagggaac atagctaata ttttaggtta tgctacttcc ttcagttctt
     1741 tgggaatgat gattgcttct attgctaatc ttataaagaa ataatagaat ttacttttat
     1801 gtcagaacaa cgacaggata aaaacttgct ctctgaacca cacaagacag aaagtgatga
     1861 gatagaaatt gatttggtcg atatctttcg caagattatt gctattcgta aaaaattata
     1921 caaagccgtt ggaattggtt ttattattgg aataattgta gcggtaagta tccctaaaca
     1981 gtatacagta aaggttaccc tttctcctga aatgggtaat gcgaagggga gtaatggttt
     2041 agccggactt gctgcctcgt ttttaggaga tggggctcta ataggggaaa gcacagatgc
     2101 cttgaacgct tctctttcag cagatattgt ttcttcaact ccttttttat tggaactttt
     2161 agaaatggaa gtctccgttt ctaaaaagga tgataaaatg actttggggt cttatctcga
     2221 tgaagagtca tctccttggt gggattatct tataggtttt ccgggcatag taataggagg
     2281 agttaaatca ttattcggag aagatacggt tcctgccagt ggagggcggc aaggaactat
     2341 cgaattgacg aaagaagtaa atgagaagat taattttctt aaaaagaaga ttagtgcatc
     2401 cattgataag aaaaccgcca taacgagcat tacggtcacc ttacaaaatc cgcagatcac
     2461 tgcggttata gcagattctg tcgttcataa attacaggaa tatattattg ggtatcgaac
     2521 ttcaaaagta aaagaagact gtgcgtattt ggaacggttg tttaaagaac gtcagcagga
     2581 atattatgct gctcaaagaa aatatgcgga ttatgtagac gcccatgata atgtggttct
     2641 tcaaagtgta cgtgctgagc aggagcgttt acagaacgac atgagtttgg cttatcagat
     2701 atatagtcag gttgctaatc agttgcaggt atccagagcc aaagtacagg aggaaaagcc
     2761 agtctttgca gtagttgagc ctgccgttgt acctttgaaa ccttcaggta tgggactcaa
     2821 aatttatatt ttattatttg tgttcctgtc cgtatctggt actctcgtgt gggtgttttt
     2881 tggcaaaagt ctgctggcta gcttgagaaa agaactgaaa aataaggaga tagaacagga
     2941 taaatgatgc taaaacgtcg tttacaacat tcttacatca attaaattca cttactatat
     3001 tattaaacga atgatacgta cagctatgat aatggctgcg ggcatgggaa cccgttttgg
     3061 ccaatataca gaattgatac ctaaagggtt cgtcaaagtg ggaggtattc caatgatagt
     3121 tcgttctatt gatactttgt tatcatgtgg cattgagcga attgtaatcg gtacaggata
     3181 taaacaagaa gtttatgaag aattgaagac agactatcct atgcttgaaa cctgttttag
     3241 tcctcgttat gctgaaacaa atagtatgta tactttatat aatacgcggg agattctggg
     3301 caatgatgat tttttattgt tagagtcaga tttgattttt gagaaacaag caataatgag
     3361 cttattggag tgtcctgcgg cagatgcaat gctaatagct ccagtgacaa agtttcaaga
     3421 tcagtattat gtggaacatg atgataattt tcgcctttct tcatgttctg tcaataagaa
     3481 taaactaaac gctaaaggcg aattggtcgg catccataaa ctatccggtt ccttttacaa
     3541 aataatgtgt gctgattatg cgagtattgt tgatgaacaa cccaatttgg gatatgagta
     3601 tgaattacta cgaatatctt gttctcaatc tcctgtttat gtgcataaag tagaagggct
     3661 gaaatggtat gaaatcgatg acatatcaga tttggaatat gcagagaaat atattgttcc
     3721 gtattgttaa ttaaaataat atatcaaatt atgagtaaga cagtttatat tgggatgact
     3781 gcggatatta tgcatccagg acttatccgc attattaatg aggctactaa atacggtgat
     3841 gttataattg gtcttcttac agataaagct attgcggagc ataaacgcct tccttatctg
     3901 acctatgaac aacgaaaaga ggtagttcag aatattaaag gcgtatgtaa agttgttcct
     3961 caagaagaat ggagctatgt tgagaatctc aaacgcatta aacctgacta tataattcat
     4021 ggtgacgact ggaaaaccgg gcctttacgt gaagaacgtg tgcgcgtatt tgaagtgatg
     4081 aatgaacagg gaggaaaggt tatcgaaatt ccatatactt tgggaattaa ttcatcttct
     4141 ttggataaag atattaaggc tataggtaca acccctgatg tacgtttaaa atcacttcgt
     4201 cgtttgataa atgccaaacc cgtagttcgt attttggaag ctcatgatgg actatgtggc
     4261 ttgataattg aaaatcagga aatattaaaa ggggataaga gggaagtatt tgacggaatg
     4321 tggtctagta gccttacgga ttcaaccagt aaaggtaaac ctgatattga ggcggttgat
     4381 ttaactaccc gattgcaaga tttgaataat attctggagt gtactactaa acctattatt
     4441 tttgatggag atacaggtgg taaaattgaa catttcgtat ttacagtacg cactttagaa
     4501 cgtcatggaa tttcagctat aataattgaa gataaagttg gattaaaaaa gaattcattg
     4561 tttggtacag atgttattca aactcaagat acaatcgaag gtttctgtaa taagatcaaa
     4621 gcaggaaagg catctcagat tactgatgat tttatgatta tcgctcgtat tgagagcctt
     4681 atagcgggaa agccggtaag tgatgcttta gagagagctt ttgcatatgt ccaagcggga
     4741 gcggacggta ttatgataca tagcaaaaat aagtcgggtg aagatataaa agaattttgt
     4801 ttggcgtttc gaaaacagta tgctcatgta cctatcgtgg ttgtgcctac tacatatgat
     4861 catatttatg agtctgaatt gtgtgattgg ggtgtgaata taattattta tgctaatcat
     4921 atgcttcgtg ccgcttatcc tgctatgatg aatgtcgcaa agataatatt agagaatgaa
     4981 cgtgctttag aggtgcgcga actgtgtatg cccataaaag aaatattgga actgattcca
     5041 ggtactaaat aaaaagagga atatcattat gttaagcgta gaaaaagttt atgaaacgtt
     5101 tctgagtcat gacgttgatt tttttacagg agttccagac tcattactaa aaaatatttg
     5161 tgcctatatc acagaccata cttcacgtga gaaacatatc atagctgcta atgaaggtgc
     5221 ggctgtagga attgcttcag gttattatat ggcatcaggt aaggttcctg tggtttatat
     5281 gcaaaattcc ggcttgggta atactgttaa tcctctgctg tctcttgcag atgaacaagt
     5341 atacagtttt ccaatgcttt tgatgattgg ctggcgtggt gaaccgggaa caaaagatga
     5401 acctcagcat aaaaaacagg gtgaggtaac tttagatttg ttgaaagcaa tgcggattcc
     5461 ttatataatt cttgattcaa atgagaatga tgcatttatt cagctccatg atatcataca
     5521 atcagcaaaa actaagaata ttcctcatgc aataattatt cggaaagatg tttttggcaa
     5581 atataaactt caaaaagagt tcggatgtaa ttatccttta tctcgtgagg atgctttgca
     5641 aatagttgtg gattatctgc ctgaaaattc agtggtcgtt tctactactg gcaagctttc
     5701 tcgtgagtta tttgaatatc gagaaatgaa agagcaaggt catgaacatg attttctcac
     5761 ggtaggctct atgggacata gttcatcaat ctctttgggt attgctatag caaagcaaga
     5821 tagacctgtt tattgcttgg atggtgatgg agcatttatt atgcatttag gggcaattag
     5881 taacattggc gatttatctc ctaaaaacta ttatcatatt ttgtttaaca atggtgctca
     5941 cgagtctgta ggaggacagc ctactttagg atttagttta gatattccgg ctattgtccg
     6001 ggggagcgga tataagcata cttatactgt ttgtacaaaa gttgaaattg aagaagcaat
     6061 gaagcagctt ccaaagttat gtggtcctgt tttgttggaa ataaaggtta aaatagattc
     6121 tcgggagaat ttgggacgtc ccacgactac tcctatagag aataaggagc attttatgga
     6181 ttttttaaaa taaatatatt cgatgaaaat agaaagaaaa atattattaa atcctgggcc
     6241 tgccactact actgacagtg taaaaatggc acaagttgtt ccggatattt gtcctcgcga
     6301 gaaagaattc gcaggtatga tgaaacaact tcgggacgat ttggtcagag ttgctcatgg
     6361 gaatttggaa aaacataccg ctgtattatt ttgtggctca ggaaccatca atattgatat
     6421 atgtctaaat tctcttcttc ctgaagacaa aagggtgctt atagtgaata atggggcata
     6481 tagtacccgt gctgtagaag tgtgtcaata ttatggtttg cctcatatta atttggaatt
     6541 ttccgtttac gaacgtcctg atttatcggt ggtggaaaat gtgttgcaag aaaatcctga
     6601 tatagctatg gtttatacta ctcatcacga gacgggtaca ggaattctga accctattcg
     6661 cgagatgggc gctatagctc ataaatatca ggctaaattt gtcgtcgata ctacttcttc
     6721 tttgggcatg attccttttg atatagagaa agataatgtg gatttttgta tggcatctgc
     6781 tcaaaaagga cttcaagcga tgacaggtct ttcttttatt ataggcaatg aggaacagat
     6841 taagttttca aaaaaatatc ccaagcgttc ttactattgt aatctttatt tgcagtatga
     6901 gaattttgag agaacaggtg aaatgcattt tactccaccg gtacaaacta tttacgccac
     6961 tcgtcaggca ttaaatgaat attttgaagt gggtgaagaa gctaagtttg cccgtcacaa
     7021 aagagttttt gaggctattc attcaggtat aaatgaaatt ggtcttaaaa gtgtaataaa
     7081 gcgtgaatgg cagtcaggac tggttgtctc agttcaatac ccagaagatc ccaactggga
     7141 ttttgagaaa atacatgatt attgttatga gcgtggattt acgatttatc caggtaagat
     7201 atcaactgag gatactttta gaatctgtgc tttaggagag atagaagtag atgatattga
     7261 gaacttcttt aaagtactaa aagctgcatt aaatcattat aacgtcacat taccgatgtc
     7321 atgattgcag aaatattatt gaagattcgt catttttatt tttcccttcg tggtatacac
     7381 ttccatccgg aaagtgttat ttctggagtg cctattcgta gctttcgctt agtaggcaaa
     7441 tatggcaata ttaatttgag gtgatgcatt aggagttctt tattcttata aaaaggcatc
     7501 ggtagttata ggagataatg tttgtgtagg gtaatttgct tttagtggga gagaccatat
     7561 tagaattgcg gtaaggggcg aagaagataa taaccaatta gtgagaatat tggaaaaata
     7621 taattgatat cggtaaatgt agttgttttt atactgtatt taagtaatgg aaaatctaaa
     7681 gcagaaaact gtatcaggaa taatgtggag cgctatagaa cgtttctctt tacaaggagt
     7741 acagtttata attcaaataa tattagctcg tttgttacta ccatcggatt atggtatgat
     7801 cgggatgtta gctatttttc ttcaagtcgc tcaagtattt atagatagcg gttttacaaa
     7861 tgctttaatc cagaaaaaag atagaactga agaggatttt gccactgtct tttattttaa
     7921 tattcttgtc gcagtattat tctatggtat attgtttttt tcggcttctt tgattgcaga
     7981 cttttataat atgccgactt tagttcttgt aattcgtttt atagcattgt cgttgataat
     8041 aaatgcttta tcggctattc acagaacgaa attaattatt tctgtaaact ttaaaactca
     8101 atctaaaatt tcattaggtg cagcttttat atcaggcgtg attggaatat ggatggctta
     8161 tgtcggttgc ggggtttggg ctttagtttg gcaaactctc ttaaatagta taattttgac
     8221 aattttgttt tactgtttag ttcattggaa acctttacat actttctcca aaagttcttt
     8281 tgaaagatta ttcaatttcg gatctaaatt attgatctca agtcttatca atacagtata
     8341 tcgtaatctg tataccattg taataggaaa aaagttttct gttgtagagc ttggttacta
     8401 tacaagagca gaacaatttg ctatttttcc ttccaataat ttaaatgctt tagtttctag
     8461 agtagcgtat cctattttaa gttccattca agatgatgat aaatgtttaa caaacgcata
     8521 tcgaaattat atcagattat cctcatatat aatttttcct ttaatggtag gtttacttgt
     8581 tttggctaat cctattatta gtctattgtt aacagataaa tggtctgggg ttgttattct
     8641 tttacagata ttatgtttgg attggatgtt tgatcatttg agccaaatta atttgaattt
     8701 attatgggtt aaaggaagat ctgatctgtc gttacgtctt gaaataataa aaaagacgat
     8761 tgctatattc attctttttg tgtcaattcc atttgggctt gaggtgatgt gttggggtag
     8821 agttatttac tctctgatag cgacatattt gaatacatat tatactaatt ctcttattga
     8881 tttgacctta aagttgcaag ttaaagatgt atttccaagt ttaatactct ctttcataat
     8941 gggggggatc gtttttatat gtatttcttt ctttgaaact gatatagtaa aaattgtgat
     9001 tggatgtatt actgggatgt ccttctatat tttactttct tttcttttta agctagattc
     9061 ttttttttgt attttaacat tgatcattaa aactaaaaac atagatgaaa atattaaaaa
     9121 agatttttca agtaatagta aagataatta accattgtgt gccagttgat agtagatcat
     9181 tgtattttat tcctcatcct aattgtagaa cagataaata tgatattata aattattcgt
     9241 cagataatgt tctcgttctg ttaaattatt tgctaaaaaa agatagtgct gaatattata
     9301 aaatatatgt tgaaatttat gattcttctc gtatttcaga atatcaagaa tatatttatg
     9361 gcataaatcc taatattagg tgtacttttt tatgtgcatg tgttggacgt tttttcttta
     9421 ataaagtatc ttttaaggat atgttgtatg cctttttttg tttttgtaga gcaagtaaat
     9481 gttttacagc tactttttat tatgattttt catttaaaaa acgctctcaa cagattattt
     9541 gtttggggta ttatactcca ttcaaagatg attatcatat gggagatcat tcttatgata
     9601 aatttcgtaa tacaacatgt aactcatttg attactctat tgctacttct tgtttaagtg
     9661 ctagaataat ttcaatagat tgtggaatct catatgataa attcaaagtc ttaggatttc
     9721 ccagaaatga tttgttgata tcgaaaaata attgcaatgt tattaaaaga gaaatttcga
     9781 aatttgcggg atatgatgta actaaatata tagtttatac tccaactttt cgtgattatg
     9841 agactgttac tgaaggtaat ttgcgttcaa tactcggata tgttgattgt gatttgttga
     9901 agttatcgaa aatactattg aagtttaatg cggctttaat tcttaaatta catcctttgc
     9961 agaataaaac agtcttaaaa aaagatttac ccaaaggtat acttgttttt gaacaaacat
    10021 ataaatatgg attgtatgat cttttgtcat tttcagatgg aatgattact gattatactt
    10081 ctacctattt tgatttttta ttggtaaata agccagtcat atttaatttc tacgatattg
    10141 aagaatatcg tagagtaaga ggtttctcat ttgagccaat agaatttttt tgtgcaggtg
    10201 atattgttta caattataat gaattgatag atgctgtgat gggacttctg gctgggaaag
    10261 atattcatgc tgaacatcga cgtcatattt ctttattgat gaatcaattt caagatgata
    10321 attcaacaaa gagaatatgt gacatatttt taaatgaaat ataataaata aaatgaatta
    10381 tgcatttgtg gtgcaggcac gtttaggttc tacacgtttg cctggaaaaa tattgaaacc
    10441 tttctatggt aatcaatcga ttcttgactt aatggttcat aagctttctg ctatatcgaa
    10501 tattccagta attattgcta caacaaattc tgttatcaat gaacctattg aaaagaaggc
    10561 acttgcatta ggggtaaagt gcttcagagg tgaggagaat gatgttttaa aacgattcat
    10621 tgatgttgct gaatattttg atatacaggg tatattccga atatgttctg ataatccatt
    10681 tttagatgta catgcggcaa ggcaattggt cgaaatagca atgaaatctt gtaacgatta
    10741 tataagtttt gatattgatg gtactccatc aattaaaact catttcggtt tttggggaga
    10801 atttgtaacg cttgatgcgc tgaagcgagt tataggattt actgatgatt tattgtatcg
    10861 tgaacatgtt actaattata tatatagtca tcctgaactt tttaatattc aatggatttc
    10921 aggatctcca gtcgtgtcaa aacatcataa tattcgactc acgattgata cgttagaaga
    10981 tttttctgta gcacagagaa tatataggga tttacaagaa aaaagagtgg aaatatcgat
    11041 agaagtgatt gtagactatg ttcgaagaca tgcagaatac attcaactga tgaaacaaca
    11101 aataaaaaaa aaattctaaa taatgaagaa tacttatatt attggtgaaa tagggcagaa
    11161 tcataatggt tctgttgact tggctaagtt gattattgaa ttaatctcac gacctgtaca
    11221 tgaggatgtt tttggtatgg atttcatgcc aatgaatgct gttaaaatga ctaaaagaga
    11281 tttatcagaa gaattggctg tttctcaaat gaatcaaata tatgacaatc ctaattcttt
    11341 tgggcgtact tatggtgaac atcgtgcttt tcttgagctt gatgatcaag cgcattttga
    11401 gatttataaa tatgctaagt cattaggatt agattttatc gagacgttat gtgccaaagg
    11461 atgtctgtct ttgcttaaac tgttcacacc ggataggcta aaagttgcta gtcgtgattt
    11521 gactaactta ccattgcttg aagcattagc agaaactcat attcctatta tattatcgac
    11581 aggaatggct ggtcaaagag aacttgacaa tgcattagat gtgataacga gatatcatag
    11641 taatatagct attctacatt gtgtatctca gtatccaact catccaaata atttgaatct
    11701 acgtacaata acatatttga agaagcatta caataagttt gagataggtt tttctgatca
    11761 tacaataggt atttctgctg ctacagctgc tgtagcgatg ggagcggaaa ttatagaaaa
    11821 gcatgtaaca attgatcggc atatgaaagg aacagaccag cttggctctt taggtccaga
    11881 tggggttaat cgtatgattc gagatattcg catagcagag tgttggcttg gtactgaaga
    11941 tctttatata gaaaaagggg tggagaagtc taagataaaa cttgaacgtt ctattgccac
    12001 tcgaaaatat attccagcag gtagtattat tcaagagtcg gacattcatt tactgagtcc
    12061 tggtgatggt tataaatgga tagataaaaa aaatgtaatt ggtcattttg ctaaacaaga
    12121 tatatcagcg aatgaaataa tatatcctga ttttattgaa tagatatatt cctactgcaa
    12181 cttgtattac ggtatagagt actgcctgct ataagctaag tagtgattaa taaataaggg
    12241 taaaatacta aaaaaatgaa agagataaag cttatactta cagatattga tggcgtttgg
    12301 actgatggcg gaatgtttta tgat
//
