LOCUS       c00166_gnlPro..         9110 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|AGCANJKK_166.
ACCESSION   c00166_gnlPro..
VERSION     c00166_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-05 01:58:37
            Original ID  :: gnl|Prokka|AGCANJKK_166
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 9110
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             complement(1..939)
                     /locus_tag="ctg166_1"
                     /transl_table=11
                     /translation="MENMNPESLLRKAQALGEDIKEMESIDVMGAYQQAQTQIKTNRRR
                     SMYNQLMRYAAFLTIPLLLSSLILGYLYWGATDTEEKYAEVMAATGSVIRYELPDHSVV
                     WLNSGSTLRYPTVFKKDNRNVELKGEAYFEVEADRKRPFYVNTPAGLSVYVYGTKFNVN
                     AYEDDNSIETVLEKGKVNVISPDGKTTVQLAPGERLLYNKVDQKLLKGKVDVYEKVAWK
                     DGKLIFRNAELGEIFKRLARHFNVDIQFNNISGKEYKYRATFRNETLPQILDYLAKSAA
                     LKWRTEEAVQQADDTFTRSEEHTSELQSRDSI"
     protocluster    1..9110
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[3838:8695]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /neighbourhood="10000"
                     /product="TPP_fatty_acids"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      3839..8695
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /neighbourhood="10000"
                     /product="TPP_fatty_acids"
                     /protocluster_number="1"
     cand_cluster    1..9110
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /kind="single"
                     /product="TPP_fatty_acids"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..9110
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_fatty_acids"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /tool="gutsmash"
     CDS             1164..1733
                     /locus_tag="ctg166_2"
                     /transl_table=11
                     /translation="MKISFSRQTKERAFKQLYEDYYAPFCLYAKRFVDDKEVREDIVSD
                     VFTSLWDKLDTDSFDLQSETALGYIKMCVKNSCLNFLKHQEYEWSYAENIQKKAPLYET
                     ETDSVYTLDELYRMLYETLNKLPENYRTVFMKSFFEGKTHAEIAEEMNLSVKSINRYKQ
                     KTMELLRNELKDYLPLFLLFLSPEQL"
     CDS             complement(1707..2813)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1025:AMP-binding enzyme (Score: 52.9; E-value:
                     7.6e-17)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg166_3"
                     /sec_met_domain="AMP-binding (E-value: 1.1e-17, bitscore:
                     52.9, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMIFDRQKQRLLLEGKEYTPGDIHSLVAEGEGNHPSAIWDLYLFL
                     NEWFNDDPVITVHTSGSTGAPKELLVRKDQMIQSARLTCEFLDLKQGETALLCMNLRYI
                     GAMMVVVRSLIAGLNLIVRRASGHPLADVDTPLRFAAMVPLQVYNTFQIPEEKEKLKQT
                     EILIIGGGAVDKALEEKIRNLSNAVYSTYGMTETLSHIALRRLNGAAASDRYYPFSSVE
                     LFLSSENTLMINAPLVCDDTLQTNDIARIYPDGSFTILGRKDNVINSGGIKVQAEEIER
                     LLQSSIPVPFVITSVPDRRLGQAVTLLIEGQMEISALGTKLESVLASYYRPKYIYTVNH
                     IPQTGNGKINRKECRVLAESLQLLGRQE"
     CDS             complement(2810..3835)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MR_MLE_C"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg166_4"
                     /sec_met_domain="MR_MLE_C (E-value: 3.3e-30, bitscore:
                     94.5, seeds: 401, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDCKIDIIPRVLHFKQPAGTSRGTYTTRKVWYLHFTAPEFPNWVG
                     IGECAPLPNLSCDDLPDYEEVLAKICRQVENQGGKLDMEALCKYPSILFGLETAIRHFF
                     EGSWALWDTPFSRGEAGIPINGLIWMGDFNRMLAQIEKKMEAGFRCIKLKIGAINFEEE
                     LALLQHIRSHYSSKEIELRVDANGAFSPTDAMEKLKRLSELDLHSIEQPIRAGQWEEMA
                     RLTSESPLPIALDEELIGYNTWEEKQRLLSAIRPQYIIIKPSLHGGLAGGEEWIAEAEK
                     LNIGWWITSALESNIGLNAIAQWCATFQNPLPQGLGTGLLFTDNVEMPLEIRKDCLWFC
                     K"
     CDS             complement(3839..4663)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: ECH_1"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg166_5"
                     /sec_met_domain="ECH_1 (E-value: 1.6e-82, bitscore: 265.8,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTQREWTTIREYEDILFDYYNGIARITINRERYRNAFTPTTTAE
                     MSDALRICREEADIDVIVITGAGDKAFCSGGDQNVKGRGGYIGKDGVPRLSVLDVQKQI
                     RSIPKPVIAAVNGFAIGGGHVLHVVCDLSIASENAIFGQTGPRVGSFDAGFGASYLARV
                     VGQKKAREIWFLCRKYNAQEALDMGLVNKVVPLEQLEDEYVQWAEEMMLLSPLALRMIK
                     AGLNAELDGQAGIQELAGDATLLYYLTDEAQEGKNAFLEKRKPNFKKYPKFP"
     CDS             complement(4667..6334)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg166_6"
                     /sec_met_domain="TPP_enzyme_C (E-value: 4.4e-09, bitscore:
                     25.6, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYSDKKNILQLVALLEAHGITKVVLCPGSRNAPIVHTLSTHPGFT
                     CYAMTDERSAGYFAIGLALNGGHPAAVCCTSGTALLNLHPAVAEAYYQNIPLVVISADR
                     PAAWIGQMAGQTLPQPGVFQTLVKKSVNLPEIQTEEDEWYCNRLVNEALLETNHHGKGP
                     VHINIPISEPLFQFTVESLPEVRVITRYQGLNVYDRDYNDLIERLNRYQKRMIIVGQMN
                     LIYLFEKRHTKLLYKHFVWLTEHIGNQTVPGIPVKNFDAALYAMPEEKTGQMTPELLIT
                     YGGHVVSKRLKKYLRQHPPKEHWHVSADGEVVDLYGSLTTVIEMDPFEFLEKIAPLLDN
                     RVPEYPRVWENYCKTIPEPEFGYSEMSAIGALIKALPESCALHLANSSVIRYAQLYQVP
                     STIEVCCNRGTSGIEGSLSTAVGYAAGSDKLNFIVIGDLSFFYDMNALWNINVRPNLRI
                     LLLNNGGGEIFHTLPGLDMSGTSHKYITAVHKTSAKGWAEERGFLYQRVENEEQLAEAM
                     KTFTQPEAMEQPVLMEVFSNKNKDARILKDYYHQLKQK"
     CDS             complement(6354..7466)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Chorismate_bind"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg166_7"
                     /sec_met_domain="Chorismate_bind (E-value: 2.4e-58,
                     bitscore: 186.9, seeds: 119, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIDEKSNLTTIDALIQRKQPFAVYRVPGEKYPRLLTEDVGAVRLI
                     FDLKELNGQRGFVIAPFRIDKSCPIVLIQSDRTGQPLPMEIVAEEEQDLQSYPEESSHT
                     LCTGKYATCFHTFIEALRDATFDKLVLSRSLTIGKNPEFSPSAVFRAACQRYIHSYIYL
                     CYTPQTGVWLGSTPEIILSGEKNEWNTVALAGTQPLQNGKLPQVWDDKNRQEQDYVASY
                     IRRQLLSLGIRSTESGPYPAYAGALSHLKTDFHFSLKDNKNLGDLLKVLHPTPAVCGLP
                     KEEAYRFILENEGYDRKYYSGFIGWLDPEGRTDLYVNLRCMHIEDEQLTLYAGGGLLAS
                     SELNDEWQETEKKLQTMRRILVSAPIMMNH"
     CDS             complement(7463..8695)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: HBT"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg166_8"
                     /sec_met_domain="HBT (E-value: 1.6e-17, bitscore: 53.0,
                     seeds: 132, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKYKLLVLDVDGTLLNDAKEISKRTLAALLKVQQMGVRIVLASGR
                     PTYGLMPLAKSLELGNYGGYILSYNGCQIINAQNGEILFERRINPEMLPYLEKKARKNN
                     FALFTYHDDTIITDTPENEHIQNEARLNNLKVIKEEEFSVAIDFAPCKCMLVSDDEEAL
                     VSLEGHWKRRLNGALDVFRSEPYFLEVVPCAIDKANTLGALLEELDVKREEVIAIGDGV
                     CDVTMIQLAGLGVAMGHSQDSVKVCADYVTASNEEDGVALAVEKAIIAEVRAAEIPLDQ
                     LNAQARHALMGNLGIQYTYADEDRVEATMPVDHRTRQPFGILHGGATLALGETVAGLGS
                     MILCQPDEIVVGMQVSGNHISSAHEGDTVRAVATIVHKGRSSHVWNVDVFTSTNKLVSS
                     IRVVNSVMKKR"
     CDS             complement(8780..9082)
                     /locus_tag="ctg166_9"
                     /transl_table=11
                     /translation="VLVDKLWPRGIKKEWLKYDYWAKDITPSAALRRWFHEDIPGHWND
                     FVVMYQKELEASQAVADFLTLIKPHPVITLLYASKEPVYNHARILRDYLEMHLKE"
ORIGIN
        1 gatggaatct cgtgactgga gttcagacgt gtgctcttcc gatcttgtga atgtatcatc
       61 tgcctgttgt accgcctcct cagttctcca cttcaaggca gcagacttag ccagataatc
      121 caatatctgt ggcagtgttt cattacggaa ggtcgcacga tatttatatt cttttcccga
      181 tatattatta aactgaatat ctacattaaa atgccgtgcc agccgtttga atatttcacc
      241 caactcggca ttgcggaata tcaacttacc gtctttccat gccacctttt cataaacatc
      301 cacttttccc ttcaacaatt tctgatctac cttattataa agcaatcgtt ctcctggagc
      361 taactgaact gttgtttttc cgtccggtga aataacgttt actttaccct tttctaatac
      421 cgtttctata ctattatcat cttcgtaagc attcacatta aatttggttc cgtacacata
      481 gacacttaac ccggcaggag tattgacgta aaaaggccgt ttcctgtccg cttctacttc
      541 aaaataggct tcacctttta attcaacatt acgattatct ttcttaaaaa cggtaggata
      601 acgtaaagta ctaccggagt ttaaccagac aaccgaatgg tcaggaagtt cgtaacgaat
      661 gactgaacct gtagccgcca tgacttctgc atacttctct tcagtatccg ttgctcccca
      721 atataaatat cccaaaatca aagaagaaag taataaaggt atagtcaaga atgcagcata
      781 acgcatcaac tgattataca tactccttct tctgtttgtc tttatttggg tctgtgcttg
      841 ttgataggca cccattacat caatagactc catttcctta atatcctctc ctaatgcctg
      901 cgcttttcgg agcaatgatt ccggattcat attttccata ttctctttca aaatcttatc
      961 ttttaattgc aattacacta atagtacaac tgaggtaatc gaaaagggac aggtataaca
     1021 tacttttttt tattttattt tttaagctat cttattttcc acagcttcat accaaaaacg
     1081 aaaaaagaaa gaaaatttta ggaaatgctg attttcttat tatatatttg aagtaaaatg
     1141 aaaaactaca gaatctcaaa ataatgaaaa tatctttttc cagacagact aaagaaagag
     1201 ctttcaaaca actttacgag gattattatg cccctttctg cctgtatgca aaaagatttg
     1261 tagatgataa agaagtccgc gaggacattg tttcggatgt attcacctcc ctatgggaca
     1321 agttggatac cgactctttc gatttgcaat cagagacagc attgggatat ataaaaatgt
     1381 gtgtaaaaaa cagctgtttg aactttctga aacatcagga gtatgaatgg agttatgccg
     1441 aaaatatcca aaagaaagct cctctatatg aaacagaaac agatagtgta tatacacttg
     1501 atgagttata ccgaatgcta tacgaaacat taaataagct tccggaaaac tatcgcaccg
     1561 tatttatgaa aagtttcttt gaaggcaaaa cacatgcgga aattgccgaa gaaatgaatc
     1621 tcagcgtaaa atccattaat cggtataaac aaaaaacaat ggaactcctg cggaacgagt
     1681 tgaaagatta cctcccgctg tttttattat tcctgtctcc cgagcaactg taagctctct
     1741 gctaaaacac ggcactcttt acgattaatc ttcccatttc ccgtttgagg aatatgattt
     1801 accgtataaa tatatttagg acgataataa gatgctaaga ctgattccaa tttagtccct
     1861 agcgcactta tctccatctg cccttctatc aataaagtaa cagcctgccc caaacgccga
     1921 tccggaacgg aagtgatcac aaacggtaca gggatagacg actgaagtaa cctttcgatc
     1981 tcttctgcct gcactttaat tcctccgcta ttgattacat tatcctttct tcccagaatc
     2041 gtaaaactac cgtccggata aatgcgggca atatcatttg tctgcagagt atcatcgcaa
     2101 acaagcggag cattaatcat caaagtattt tctgaagaca aaaacaactc tacggatgaa
     2161 aaaggataat aacgatcgga tgctgctgcg ccattcagac ggcgaagagc gatgtgagaa
     2221 agggtttccg tcatcccgta agttgaataa acagcattgg acagatttct gattttttcc
     2281 tctaaagcct tgtcaactgc tccgcctcct ataattaaaa tctccgtttg ctttaatttc
     2341 tctttctctt cgggtatctg aaatgtatta tacacctgca aaggcaccat agccgcaaac
     2401 cttaaaggag tgtccacatc tgccaatgga tgaccggaag cccgacgtac tataagattc
     2461 aacccggcaa tcaaagaacg gacgactacc atcatcgccc cgatatagcg aaggttcata
     2521 cacaataatg ccgtttcacc ctgctttaaa tccagaaact cacaagtcag gcgtgcactc
     2581 tgtatcatct gatctttgcg aacaagcaat tctttaggtg cccccgtaga accggaagta
     2641 tgtacagtga tcacaggatc atcattaaac cattcgttta gaaaaagata caagtcccat
     2701 atagcagaag ggtggtttcc ctcaccttct gctacaaggc tatgtatatc gcccggagta
     2761 tattcctttc cctccagcaa caaacgctgt ttttgtcggt cgaatatcat catttacaaa
     2821 accacaaaca atcttttctg atttcaagag gcatctctac attatctgta aagagtaacc
     2881 cggtgcctaa cccttgcggc aatggattct gaaaagtagc acaccattga gcgatagcat
     2941 tcagaccgat attagactcc agagcagaag ttatccacca accgatattc agtttctccg
     3001 cttctgcaat ccactcctcg ccaccggcta atccgccatg aagagaaggt ttgataataa
     3061 tatattgcgg acggatagcc gaaagtaatc tttgcttttc ttcccaggta ttatagccta
     3121 tcagttcctc atccaaagct atcggcaaag gagattcgga agtaagacgt gccatttctt
     3181 cccattgtcc ggcacgaatg ggctgttcta tcgaatgtaa gtccagttcg gacaagcgtt
     3241 tcaatttctc catcgcatct gttggtgaga atgctccgtt ggcatctaca cgcaattcta
     3301 tttctttaga agaatagtga gagcggatat gttggagtaa agccagttct tcttcaaagt
     3361 tgatggcacc gatcttcaac tttatacagc ggaatcccgc ctccatcttc ttctctatct
     3421 gagcaagcat tctattgaag tcacccatcc agataagccc gtttatcgga atacctgctt
     3481 ccccacgtga gaagggtgta tcccacaaag cccagcttcc ttcaaaaaag tgacgaatgg
     3541 ctgtctccaa gccaaaaagg atggaagggt acttgcatag agcttccatg tccagcttac
     3601 ctccctgatt ctctacctgc cggcagattt tagccagcac ttcctcgtaa tcgggaagat
     3661 catcacagct aagatttggc agaggagcgc actccccgat ccctacccaa ttgggaaatt
     3721 cgggagcagt aaaatgaaga taccagactt ttcgcgttgt gtatgtgcct cgtgaagttc
     3781 cggccggctg cttgaaatga agcacccgcg gaataatgtc tattttgcaa tccattgttt
     3841 aagggaactt cggatatttc ttaaagttag gtttacgttt ctccagaaat gcattctttc
     3901 cttcctgagc ctcatccgtc agatagtaaa gcaaggtcgc atcccctgcc agctcctgaa
     3961 tacctgcctg gccgtccagt tcggcattca atccggcttt aatcatccgc aaggccaacg
     4021 gactgagcag catcatttct tccgcccatt gcacatactc atcctccagt tgctccaatg
     4081 gaactacttt attcaccaat cccatatcca acgcttcctg cgcattgtat ttccggcaaa
     4141 ggaaccatat ctcacgtgcc ttcttctgac cgacgacacg agccagataa gaggctccga
     4201 aacctgcatc aaagctacct acgcgaggac cggtctgtcc gaagatcgca ttctccgaag
     4261 caatcgataa atcgcaaact acatgaagca cgtgtccgcc accaatggca aatccattta
     4321 cggcagcaat taccggtttc ggaatgctgc ggatttgttt ctgtacatcc agaacactca
     4381 gacggggaac accgtccttg ccgatatagc cgccacgccc tttcacattc tggtcaccgc
     4441 ccgaacagaa agccttgtca ccagctcccg taatcacgat cacatcaata tccgcttctt
     4501 cccggcaaat gcgcaatgcg tcactcattt cagccgttgt agtcggagta aatgcatttc
     4561 gatagcgttc acggttaatg gtgatgcggg caatcccatt atagtaatca aagaggatat
     4621 cttcgtattc tctgatggtt gtccattctc tttgtgttga cataatctat ttttgtttta
     4681 gttgatgata ataatctttc agtatacgtg catctttatt tttattgctg aatacttcca
     4741 tcagaaccgg ttgttccatg gcttccggtt gtgtgaaggt tttcatcgct tcggcaagct
     4801 gttcttcatt ctctacccgt tgataaagga atccgcgttc ttccgcccat cctttggcag
     4861 atgtcttgtg aacggctgta atatacttgt gcgatgtacc cgacatatcc agtccgggta
     4921 atgtatggaa aatctcccct cctccgttat tcagcaaaag aatgcgtaga ttgggacgga
     4981 cattgatgtt ccacaaagca ttcatatcat aaaagaaact aaggtcacct ataactataa
     5041 aatttagttt atccgaaccg gcggcatatc ccactgccgt ggacaacgag ccttcgatgc
     5101 cgcttgtacc ccgattacag catacctcaa tcgtagaagg aacctggtat aactgagcat
     5161 agcggataac agaactattt gccagatgca atgcacatga ttccggcaat gcttttatca
     5221 aagcaccgat agccgacatt tccgaatatc cgaactccgg ttcgggaatg gtcttgcaat
     5281 aattctccca tacacgggga tactccggca cgcggttatc cagcaatgga gctattttct
     5341 ccagaaactc aaacgggtcc atttcgatga cggtagtcag agaaccgtaa aggtcaacca
     5401 cttctccatc agcagacaca tgccaatgtt ctttaggcgg atgctgccga agatattttt
     5461 tcaaccgctt ggaaaccaca tgtccgccat aagtaatcaa taactcggga gtcatctggc
     5521 cggttttctc ttcgggcatc gcataaagcg ccgcatcaaa attcttcact ggaataccgg
     5581 gtactgtctg attaccgata tgctcggtca gccacacgaa atgtttatat aacaatttgg
     5641 tatgccgttt ctcaaacaag taaatcaagt tcatctgtcc gacaataatc atccgcttct
     5701 gatatctgtt caagcgttcg atcaggtcat tgtaatcccg gtcgtataca ttcagcccct
     5761 gatagcgcgt aatgacacgt acttcgggaa gcgactccac cgtaaactgg aacaaaggtt
     5821 cggatatagg aatattaata tgtaccggac cttttccatg atggttggtt tccagcaagg
     5881 cttcattcac caagcggtta cagtaccatt catcctcttc tgtctgaatc tccggaaggt
     5941 ttaccgactt cttcaccaat gtctgaaaaa caccgggctg cggcaatgtc tgtcccgcca
     6001 tctgtccaat ccaggcagca ggccgatcgg cagagataac aactaaaggt atattctgat
     6061 aatacgcttc tgccacagca ggatgaagat tgagcaacgc tgtaccggaa gtacagcaaa
     6121 cggcagcagg atgcccgcca ttcagcgcaa gaccaatcgc aaaataaccg gcactccgtt
     6181 catccgtcat agcataacaa gtaaaacccg gatgagtaga cagcgtatgc acaataggtg
     6241 cattacggct accgggacat aacactactt tcgtaattcc atgcgcctca agcagcgcga
     6301 ccaactggag tatatttttc ttgtccgaat acatattgat agtgattagc ttgttagtga
     6361 ttcatcatta ttggagcaga cacaagaata cgcctcatgg tctgcaattt cttttccgtt
     6421 tcctgccatt catcattcaa ctctgaagag gctaacaatc cgccaccggc atacagtgtc
     6481 aattgctcgt cttcaatgtg catgcaacgc agattcacat acaaatctgt gcgtccctcc
     6541 ggatcgagcc aaccgataaa accggaataa tacttacgat cgtacccttc attttccaaa
     6601 atgaaccggt aggcttcttc tttaggcagt ccgcacacgg caggagtcgg atgcaggact
     6661 ttcagaaggt ctcccagatt tttattatct ttcaaagaga aatggaaatc agttttcaga
     6721 tgtgacaagg caccggcata agccggataa ggtccgctct ctgtggagcg aatgcccagc
     6781 gaaagaagct gccgacggat ataggacgcc acataatcct gctcctgacg gtttttgtca
     6841 tcccatactt gcggaagttt accattctgc aaaggttgag ttcctgccag ggcaactgtg
     6901 ttccattcat ttttttcgcc cgacaatata atttcggggg tacttcccag ccacacgccc
     6961 gtctgaggag tataacacag atagatatag gaatgaatat aacgttgaca agctgcacga
     7021 aaaacagctg aaggggaaaa ctccggattc tttccaatag tgagactacg ggaaagcacc
     7081 agtttatcaa aggtagcatc acgcaaggct tcaataaatg tatgaaaaca ggtcgcatac
     7141 ttcccagtac aaagggtatg agaagattcc tccggataac tttgcaagtc ctgctcttcc
     7201 tctgccacga tttccatagg caacggttgt ccagtcctgt cggactgtat caacacaatc
     7261 ggacatgact tatctatacg gaacggagca atcacaaatc ctctttgtcc attcagttct
     7321 ttcaaatcga aaatcaagcg gacagctccg acatcttctg tcaacagacg aggatacttc
     7381 tccccgggaa cacgataaac agcaaagggc tgtttccgct gaataagtgc atcaatagtt
     7441 gtcaagttac ttttttcgtc aatcatcttt ttttcatcac actgttgacc acccgtatag
     7501 aggacaccag tttattggtt gaagtaaaaa cgtccacatt ccatacatgg gaggaacgtc
     7561 ctttgtgtac aatcgtcgct actgcacgta ctgtatcacc ttcgtgcgca gaagatatat
     7621 gatttccgct gacctgcatt cctaccacaa tttcatccgg ctgacagaga atcatcgagc
     7681 cgagtccggc aactgtttct cccaatgcaa gcgtagctcc accgtgcaaa ataccgaacg
     7741 gctgacgggt acggtgatct accggcatcg tcgcctctac acggtcttcg tcggcatatg
     7801 tatattggat acccagatta cccatcaatg cgtgacgcgc ctgtgcattc aactggtcca
     7861 aaggaatctc tgcagcgcga acttccgcta ttatcgcctt ttcgacagcc agagccactc
     7921 cgtcttcctc attggaagct gtcacataat ccgcacagac ctttaccgaa tcctgcgaat
     7981 gccccatcgc cactcccagt cctgccagct gaatcatcgt tacatcgcac acaccgtctc
     8041 ctatagcgat gacttcttca cgcttcacat ccagttcttc caataaagct cccaatgtgt
     8101 tggctttatc aatcgcacac ggcactactt ccagaaaata aggttcggaa cggaaaacat
     8161 ccaaagctcc gttcaaccgt ctcttccagt gtccttccag actaaccaac gcttcctcgt
     8221 catcgctgac aagcatacac ttacacggag caaagtcaat tgctacagaa aattcctctt
     8281 ccttgatcac tttcaaatta ttcaagcgag cttcattctg gatatgttca ttctccggag
     8341 tgtcagtaat gatcgtatca tcatggtaag tgaacagtgc gaaattattt tttcttgcct
     8401 tcttttccag ataaggcaac atttccggat taatcctccg ctcaaacagt atttctccgt
     8461 tttgagcatt aattatctgg caaccattat aagaaaggat ataacctcca taatttccga
     8521 gttctaggga tttggctaaa ggcatcagac cgtaagtcgg tcggccggat gccaacacga
     8581 tacgtactcc catctgctga actttcagca aagcagccaa tgtacgttta ctaatttctt
     8641 ttgcatcatt gagaagcgtt ccgtctacat caagaactaa taatttatac ttcatggaca
     8701 cacgattttg atttagatta caaaggtagg aaattgagtg aacgactgaa agcggaaaga
     8761 gataaaaatt actttaattt cactctttca gatgcatttc caaataatca cgaaggattc
     8821 gggcatgatt ataaaccggt tctttggatg cataaagcaa agtgatcacc ggatgaggtt
     8881 tgataagagt cagaaaatcg gcaacagctt gagaagcttc cagttccttc tgatacatta
     8941 cgacaaaatc attccagtga cccggaatat cttcatgaaa ccatctgcgc agtgctgcgg
     9001 aaggcgttat atcttttgcc cagtaatcat atttcaacca ttcttttttg attccacgtg
     9061 gccagagttt atctaccagc acccgatatc cgtcggtcta tgaaaagtct
//
