LOCUS       gnlProkkaMIEDEGKM_26   11162 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|MIEDEGKM_26.
ACCESSION   gnlProkkaMIEDEGKM_26
VERSION     gnlProkkaMIEDEGKM_26
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-18 01:06:47
            Original ID  :: gnl|Prokka|MIEDEGKM_26
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 11162
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..11162
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[2593:6162]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      2594..6162
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..11162
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..11162
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             complement(3..608)
                     /NRPS_PKS="Domain: NAD_binding_4 (10-144). E-value:
                     1.4e-07. Score: 22.7. Matches aSDomain:
                     nrpspksdomains_ctg26_1_NAD_binding_4.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010:NAD-dependent epimerase/dehydratase (Score: 92.1;
                     E-value: 7.1e-28)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg26_1"
                     /sec_met_domain="Polysacc_synt_2 (E-value: 4.5e-80,
                     bitscore: 260.3, seeds: 77, tool: rule-based-clusters)"
                     /sec_met_domain="RmlD_sub_bind (E-value: 1.1e-08, bitscore:
                     25.9, seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSVFKDKVLLITGGTGSFGNAVLRRFLDSDIKEIRIFSRDEKKQD
                     DMRHHLQNPKVKFYIGNVRDRQSVDGAMMGVDYVFAAAALKQVPSCEFFPLQAVQTNVI
                     GTDNVLESAIAHGVKNVVVLSTDKAAYPINAMGISKAMMEKVAIAKGRALGEEAGTTIC
                     CTRYGNVMASRGSVIPLWVEQIKNGRPITVTDPNMTRFM"
     aSDomain        complement(177..578)
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg26_1_NAD_binding_4.1"
                     /evalue="1.40E-07"
                     /label="ctg26_1_NAD_binding_4.1"
                     /locus_tag="ctg26_1"
                     /protein_end="144"
                     /protein_start="10"
                     /score="22.7"
                     /tool="antismash"
                     /translation="ITGGTGSFGNAVLRRFLDSDIKEIRIFSRDEKKQDDMRHHLQNPK
                     VKFYIGNVRDRQSVDGAMMGVDYVFAAAALKQVPSCEFFPLQAVQTNVIGTDNVLESAI
                     AHGVKNVVVLSTDKAAYPINAMGISKAMME"
     CDS_motif       complement(525..581)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg26_1_0001"
                     /evalue="7.90E-04"
                     /label="PKSI-KR_m1"
                     /locus_tag="ctg26_1"
                     /protein_end="28"
                     /protein_start="9"
                     /score="12.1"
                     /tool="antismash"
                     /translation="LITGGTGSFGNAVLRRFLD"
     CDS             complement(623..1738)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_1"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg26_2"
                     /sec_met_domain="Glycos_transf_1 (E-value: 2.1e-12,
                     bitscore: 38.5, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNILINCSNLKKGGGLQVADSVCSCLNTIPQHDFFLVLSSCMDDT
                     ADRVSEYKNVTVVRHDIRNSWYTLFWGRDKAMDNLVTRHNIGGVLTIFGPARWKPKCKH
                     LCGFARSHLVLNDSPYFQRMSWKELMIEKARNLYLYYYFKRGVTAFWTENPYISEKVKH
                     LFPTIKAYTVSNYYNQVFDDENTQIEHALPSFDGCTLLSINAPYPHKNLAIAIEVARYL
                     KKHYSEFSFRFVFTVTENDLPPIPSYLREHFCLIDKVSVAECPSLYRQADIMFQPTLLE
                     CFTATYVEAMRMQVPILTTDLPFAHGLCGNAAVYYSPLDAEDCAKSIYKMAVDTSFQDY
                     LVGEGIKQLKSFDNYNRRAEKLIDLISNLDD"
     CDS             complement(1797..1886)
                     /locus_tag="ctg26_3"
                     /transl_table=11
                     /translation="MKTNFNIRSIIVINKIIINFFFRQYRWYL"
     CDS             complement(1893..2609)
                     /locus_tag="ctg26_4"
                     /transl_table=11
                     /translation="MSRGISEKEQRWLLVLSQVIEVLDKNNLLYFIDTGTLLGAVRDKM
                     FIPWDNDIDLAVIGGDTSTTNLLKVSKLLYALGFYVTLTKKEIAICSRDGVNLGIKLYK
                     KQASHYEACMGKVYRHRLFYSINLYLSGEVLYKKGFSFKYKAISLFVKFSQVFKLKLSC
                     IWQMKLLFWAKYDEKTVIIPFEFVDAIIDYNFYNIIVKVPNKPERYLAYRYGENWKVPK
                     QDYDYMIDDKSIINID"
     CDS             complement(2594..3688)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Fe-ADH"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg26_5"
                     /sec_met_domain="Fe-ADH (E-value: 5.3e-76, bitscore: 247.2,
                     seeds: 218, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEQRFFLGESSIKELIPILQEYTPDHIFLVRGKKSYEKCGAQAVL
                     ESVFVKLACGVTEFFDFEANPKIEDMEKGLSLLKEYPTNMIIAIGGGSVLDMAKLLRFF
                     YSYSGNPTGGEFEKKRQLIPLITLPTTAGTGSEATHFSVLYKDKVKYSVEHDAILPDVA
                     IVYPKFTYGNSKYLTSCTGFDALAQAIEAYWNVNATEESDKYAAKAIKLLWPNLPLVVN
                     SPTAEARNKVSEGSYWAGRAINITKTTAPHAFSYSFTTDYGYPHGHAVALTFPFFMRYN
                     IGNSDILLNPNINPYLYKIKMQKMLQWLNMECVDVAIAMKEYIRNLGLDIDISQIDISK
                     IVSSVNIQRLINNPYKVEAICLEE"
     CDS             complement(3696..4826)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 69;
                     E-value: 6e-21)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg26_6"
                     /sec_met_domain="TPP_enzyme_N (E-value: 6.3e-17, bitscore:
                     53.2, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1e-20, bitscore:
                     65.5, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MISPNIFVDSLGAMQMDFFTGVPDSLLKNICAYLTDHLASEHNII
                     AANEGAAIGLATGYYLATRKIPVVYMQNSGLGNAVNPLMSLTDKEVYNIPLLLLIGWRG
                     EPGVKDEPQHIKQGKVTLPLLEAMGIRYAVLSQDEKKFISQLNVAKSYMDETREPFAFV
                     IQKDTFLEYSSENCEDERLSLKREAAIHFIAASLTEKDIIISTTGMISRELFEYRESTS
                     LEHERDFLTVGSMGHASQIALGIALKKRDCKVYCFDGDGSTLMHMGSLAIVGSLHPENY
                     VHVVFNNGAHDSVGGQPTVALDIDLCKIAQACGYEIVLSVSDNEGLCEALKKIQQIRGP
                     ILLEVKVRKGARKNLGRPANTPIQNKEAFMLFLDNL"
     CDS             complement(4858..6162)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 202.6;
                     E-value: 1.3e-61)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg26_7"
                     /sec_met_domain="CTP_transf_like (E-value: 1.1e-12,
                     bitscore: 39.8, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates (E-value: 2.9e-119, bitscore:
                     388.9, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 9.6e-64, bitscore:
                     206.6, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEKKKVYVGMSADIIHPGHLNIIHEASKLGHVTVGVLTDSAIASY
                     KRLPYLNFDQRSLIVLNLKGVDEVIPQTTLDYVPNLELIRPDFVVHGDDWKEGIQQETR
                     QRVIDTISKWGGKVIDVPYTKGISSTLLNTRLKEIGTTPEIRLKRLKRLIAAKSIVRIC
                     ESHSGLTGLIIENTSVEVNGVKREFDGMWSSSLTDSTSKGKPDIEAVDLTTRLHDLNDA
                     LECTTKPVIFDGDTGGKIEHFVFTVRTLERLGISAVIIEDKIGLKKNSLFGTDAVQTQD
                     TIEGFCDKIQAGKRAQITDDFMIIARIESFIAGKGLDDALGRALAYIKAGADGIMIHSK
                     DKSGEDIKNFCLALRKIHKSIPIVVVPTTYNHISEDELASWGVNVVIYANHMLRSAYPA
                     MLNTAKSILANARSYEANDLCMPIKEILELIPGTK"
     CDS             complement(6125..7327)
                     /locus_tag="ctg26_8"
                     /transl_table=11
                     /translation="MLLLINVWAFNWGFLCFGKIKKIRLKVTTDNSFYNLVIGNNKMIL
                     LLMLACIVTYYYAMKFALVIELYGAGEGRMMRFEAGELFTSNLEVYLYDFLIKPFTQFV
                     MLIVACMLLSKIKRRILLLSVLFLFLYASVGNGRGGLIVFLFYCFIIYYLRRELYYINL
                     LASKRKKWNFGVVSFVCLFVGVGIIVVVISYMTAQRMGFDTFSAEVVKIGFEELKSQAV
                     WYFLGPFRALDYSFRANYESITGFWYGRATMGGIDNLLKLVIHYLGGSYTIAHDEIGHL
                     LQNSKISVGNGIIFNYAYTNIIFHYLDFGYVGVLLFPFLYGFIVRYSIYKFTQKPTLLT
                     LGIMIYLVYISMFNIFSWEFQKPSSIIYVLLLLFFQYVYSHKFVILKLNGKKKGLCRHE
                     C"
     CDS             complement(7501..7968)
                     /locus_tag="ctg26_9"
                     /transl_table=11
                     /translation="MDVRLFHTASFLFKKEVLDYIKDFNSSLYAGDRFLFLACSLKGNI
                     LYMPDVMCCYRKNAMGVTSRVSYSLHVLDLKVPEYFHNKDLKFPYYRYLAFVHRAIFSE
                     SLDISLKKYIYHFTLFVKYSFSYFPKNLKDIYKALYVSFWWLTKGQKYRIK"
     CDS             8019..8243
                     /locus_tag="ctg26_10"
                     /transl_table=11
                     /translation="MEFHSHKKLKIDAHNLLTNDHSPLHLLVFVTSTDQSNNHPPHKAQ
                     HIYLLLKEIIFDVTEKYLENTGFESEELV"
     CDS             complement(8434..9429)
                     /NRPS_PKS="Domain: NAD_binding_4 (91-233). E-value: 3e-07.
                     Score: 21.7. Matches aSDomain:
                     nrpspksdomains_ctg26_11_NAD_binding_4.1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010:NAD-dependent epimerase/dehydratase (Score:
                     114.5; E-value: 1.1e-34)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg26_11"
                     /transl_table=11
                     /translation="MKKKIIIFGATGNTGSYLLEYALNFFNKEEYEIIASGRRETTFFS
                     KRGIPYYSVDITKEEDFDKLPMENIHAVMLLSAQIPSYMDTYCPIKYLDSIVIGGFNVL
                     EYCRKCHVDRIIYTQTVFDISLYSHDTILKPDMKPNFSYTGDHAIYVISKNTALDLIEH
                     YYQEYGLKKFIFRLPTIYSYSPYPYYFPNGVKTKRPIYQMIENAQKGLPIEIWGDPHYA
                     KDMVHVNDFSQMLCKAVEVEQESGFYNVGTGMPITLEEQIRTIISVFSPKESPSEVIYR
                     PDKVCGGGYIMNIENAKKELGYVPQYDCRKLFEDYKSEMEIKRFAELRLK"
     aSDomain        complement(8731..9156)
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg26_11_NAD_binding_4.1"
                     /evalue="3.00E-07"
                     /label="ctg26_11_NAD_binding_4.1"
                     /locus_tag="ctg26_11"
                     /protein_end="233"
                     /protein_start="91"
                     /score="21.7"
                     /tool="antismash"
                     /translation="YLDSIVIGGFNVLEYCRKCHVDRIIYTQTVFDISLYSHDTILKPD
                     MKPNFSYTGDHAIYVISKNTALDLIEHYYQEYGLKKFIFRLPTIYSYSPYPYYFPNGVK
                     TKRPIYQMIENAQKGLPIEIWGDPHYAKDMVHVNDFSQ"
     CDS             complement(9426..10391)
                     /locus_tag="ctg26_12"
                     /transl_table=11
                     /translation="MMSIGGYFELEIREGEHFHQGAIKLSTARQCFEYILKARRYTKVY
                     IPYYTCDVIIEPLMKLNVKYEYYHINSLLDPVFDKKIESSEAFLYTNYFGLKQDTVLYL
                     SRFYPNLIVDNAQAFFAKPIEGVDTFYSARKFFGVPDGAYLYTTALLDIDFPIYNPIDN
                     INYLIGRITDSAEGYYKDFQESEERMSNQEIHRMSVLSDKILSSLDYVSIIERRRFNYH
                     LLYSALTAFNKFDFSISENQNVPLIYPFYTSKAGLRQQLILEHVYVPQYWQNVVNKIDA
                     KCLEYSIANNMIALPIDQRYDEKTMNILIEKISNLNNHLS"
     CDS             complement(10388..11077)
                     /locus_tag="ctg26_13"
                     /transl_table=11
                     /translation="MKLGIMQPYFMPYIGYFQLIKAVDKYVVYDDVNYIKGGWVNRNNI
                     LVNGEKKMFTITLKGASAYKHFNEIEIGDDFRKFMKTLELNYSKAPFYHETMELLYRII
                     MFPNRQLALFLANSFKEILDYLNIQTEILLSSDLPKDCSLKGKDKVLHICKLLSADTYY
                     NAIGGKQIYNKEDFMQNGINLKFVDTIIKRYPQQSKEFVPYLSIIDVLMNNSKEETCML
                     LDSFSLQ"
ORIGIN
        1 atcatgaaac gggtcatgtt ggggtccgtt accgtaatgg gcctgccgtt ctttatctgc
       61 tccacccaca agggaattac agaaccgcgg cttgccatca cattgccgta acgggtacag
      121 cagatggtcg taccggcttc ctcacccaac gcacggccct tggctatggc aaccttctcc
      181 atcatggcct tgctgatacc catggcattg atgggatagg cggccttgtc ggtagaaagc
      241 accaccacat tctttacacc atgcgctatg gcagattcca gtacattgtc cgtaccgatc
      301 acattggtct gcacagcctg caacgggaag aactcgcaac tgggaacctg cttcaaggcg
      361 gcagcggcaa atacataatc cactcccatc atggcaccgt ctacagactg gcggtcacgg
      421 acattaccaa tgtaaaattt tactttggga ttttgcaggt gatgacgcat gtcatcctgc
      481 tttttctcgt cacgactaaa aatacgaatc tccttgatat cagaatcaag gaaacgacgc
      541 aatacagcgt taccaaaact gccggtacct ccggttataa ggaggacttt gtctttaaat
      601 actgacataa atataatatg tattaatcat ccaaattcga tatcaaatcg attaattttt
      661 ctgctctccg attataatta tcgaaggact taagttgttt tattccttct ccgaccagat
      721 aatcttgaaa ggatgtgtct acagccattt tataaattga tttggcacag tcttctgcat
      781 ctaacggcga atagtacaca gctgcatttc cacataatcc atgagcaaat ggcaaatctg
      841 tagttaaaat tggcacttgc attcgcatcg cttcgacata tgtggcagtg aaacattcaa
      901 gtaaagttgg ttgaaacatt atatctgcct gacgatataa ggaagggcat tctgctacac
      961 taactttatc aatcagacag aaatgctctc gcaaataaga aggaataggt ggcaagtcat
     1021 tctctgtcac cgtaaaaacg aatcgaaaac taaattcgga ataatgtttt ttaagatatc
     1081 gagcgacttc gatagcaatt gctaaattct tatgaggata aggagcattt atggacagta
     1141 aagtacaacc gtcaaaagac ggtaaggcat gttctatttg agtattttca tcatcgaaaa
     1201 cctgattata ataattcgat acagtatagg cttttatggt agggaacaag tgctttactt
     1261 tctctgaaat ataaggattc tcagtccaaa aagcagtcac accacgtttg aagtaataat
     1321 ataaataaag atttctcgcc ttttctatca ttagttcctt ccaagacata cgttgaaaat
     1381 agggagaatc gttcaaaacg agatgggatc tggcaaatcc acatagatgc ttacatttcg
     1441 gcttccatct tgcaggtccg aatatggtaa gaactccacc aatattgtgt ctggttacca
     1501 aattatccat agccttatca cgtccccaaa acaatgtata ccaactgttt cgtatatcat
     1561 gacgcactac agtgacattt ttgtattccg ataccctatc agcagtatca tccatacatg
     1621 aggataatac taaaaaaaaa tcatgttggg gaattgtatt caaacaagaa caaaccgaat
     1681 cagcgacttg aagccctcca cctttcttga gattggagca atttattaga atgttcattt
     1741 gttccgagaa tataatatat aagtgcccaa ttttggtgta taaatgaaag tgctatttat
     1801 aaataccatc tatattgtct aaagaaaaag ttgattataa ttttattaat tacaataata
     1861 ctccttatgt tgaaatttgt tttcatattt ttttaatcaa tatttataat agacttgtca
     1921 tcaatcatat aatcatagtc ttgtttggga accttccaat tttcaccata tctatatgct
     1981 agatatcttt ctggcttatt tggcactttc acaattatat tataaaaatt ataatcaata
     2041 attgcatcta caaactcaaa aggaataatc accgtctttt catcatactt agcccaaaac
     2101 aataacttca tttgccaaat acaagacaat tttaacttaa agacttgact aaacttcaca
     2161 aagagtgaga tagctttata cttaaaagaa aagccttttt tatacaggac ctctccagag
     2221 aggtataaat ttatagaata aaatagtcta tgtctataaa cttttcccat acatgcttca
     2281 taatgacttg cttgcttttt atataattta attcctaaat ttaccccgtc tctagaacag
     2341 atagcaattt ctttctttgt caaagtgacg taaaagccta aagcatataa caattttgac
     2401 actttaagca aattagtagt agatgtatct cctccaataa ctgctaaatc aatatcatta
     2461 tcccaaggaa taaacatttt atctctaaca gctcctaaaa gagtaccagt atcaataaaa
     2521 tataataaat tatttttatc aagaacttca ataacttgtg ataatactaa caaccatcgt
     2581 tgctcctttt cacttattcc tctagacata tcgcttcaac tttatatgga ttgtttatta
     2641 atctttgaat attaacagaa gatacgattt tcgatatgtc aatttgagat atgtcaatat
     2701 ctaatcccaa gtttcttata tactctttca tagcgattgc aacatctacg cattccatat
     2761 ttaaccactg taacattttt tgcattttaa tcttatataa gtaaggattt atattaggat
     2821 tcaataagat atccgaattt ccaatattat atctcataaa aaagggaaat gttaatgcta
     2881 ctgcatgtcc atgcggatat ccataatcag ttgtaaatga atacgaaaaa gcatgtggag
     2941 ctgtagtctt agttatatta attgcacgac cagcccaata agagccttcc gaaaccttat
     3001 tcctagcctc cgctgtagga gaatttacaa ccaatggcaa attaggccat aagagtttaa
     3061 ttgctttcgc cgcatattta tccgactctt ccgtagcatt cacattccaa taagcttcta
     3121 tcgcctgcgc tagagcatca aagcctgtac aagatgttag atattttgaa tttccataag
     3181 taaattttgg atatacaatc gctacatccg gaagaatagc atcatgttct actgaatatt
     3241 ttactttatc tttatataaa acagaaaaat gagttgcttc actacctgta ccagctgtag
     3301 taggaagtgt tattaatgga attaattgtc gcttcttttc aaactccccc cccgtaggat
     3361 taccagaata ggaataaaaa aaacgaagca attttgccat atctaataca ctacctccac
     3421 ctatagcaat aatcatattt gtcggatatt ctttcaataa tgaaagtcct ttttccatat
     3481 cttcaatttt aggatttgct tcaaaatcaa agaattccgt cacgccacaa gctaatttaa
     3541 caaaaacaga ttctaacaca gcctgtgcac cacatttctc ataagacttt tttcctctta
     3601 caagaaatat atgatcagga gtatattctt gcaagatagg aatcaattct tttatagaag
     3661 actctcctaa aaaaaaacgc tgttccataa ttactctata aattatctaa gaaaagcatg
     3721 aatgcctctt tattttgtat aggagtgttg gctggtcttc ccaaattctt acgagctccc
     3781 tttcgaacct ttacttccaa caaaataggg ccgcgtattt gctgtatctt tttaagagct
     3841 tcacataaac cttcgttatc agaaacagac aatactattt cataaccaca agcttgagca
     3901 attttacata aatcaatatc taaagcgact gttggttgtc cccccacaga atcgtgagcg
     3961 ccattattaa agactacgtg tacatagttt tccggatgta aagaaccgac aattgctaac
     4021 gaacccatat gcatcaaagt ggaaccatct ccatcaaagc aataaacttt acagtctctc
     4081 tttttaagag ctattcccaa tgctatctgc gacgcgtgcc ccatagaacc tacagtcaaa
     4141 aaatctctct catgttctaa agaagtagat tcacgatatt caaataattc acgtgatatc
     4201 atacctgttg tcgatattat aatatctttt tctgttaatg aagctgctat gaaatgaata
     4261 gcagcttcgc gtttcaaaga caaccgttca tcttcacaat tttcagaact atactctaag
     4321 aaagtgtctt tctgaattac aaaagcaaaa ggctctcttg tctcatccat gtaagatttt
     4381 gcaacattaa gttgagatat aaacttcttt tcatcttgag ataaaacagc atatctgata
     4441 cccattgcct caagtaatgg aagtgtgact tttccctgct taatatgttg tggctcatct
     4501 ttcacaccag gttcaccacg ccaaccaatt agcaataaca atggaatatt ataaacttct
     4561 ttatccgtca atgacattaa aggatttact gcatttccaa gacctgaatt ctgcatataa
     4621 acaactggaa ttttcctcgt agccaaataa tatcctgtag ccaaacctat agcagcacct
     4681 tcattagcgg caataatgtt atgttcagaa gcaaggtgat ctgttaaata tgcacatata
     4741 ttcttcaata aagaatcggg aactccagta aaaaaatcca tctgcatagc gccaagagag
     4801 tctacaaaaa tattaggaga aatcataata ataagaattt aattttaaag agtctattta
     4861 cttagtccct ggaatcaatt ccagaatttc tttaataggc atgcataagt cattggcttc
     4921 ataagagcgt gcattggcaa gaatggactt cgccgtatta agcatagcgg gatatgcact
     4981 tctaagcata tgatttgcat atattacaac atttactccc caagaagcca attcatcttc
     5041 tgatatatgg ttataagtag ttggaacaac cactatcgga atggatttat gtattttgcg
     5101 taaagcaaga cagaagttct ttatatcctc accagactta tctttgctat ggatcataat
     5161 cccatccgca cctgctttaa tatatgctaa tgcacgtcct aaagcatcat ctaaaccttt
     5221 tccagcaata aaactttcaa tacgagctat tatcataaaa tcatccgtta tctgagcacg
     5281 tttacccgct tgaattttat cacaaaaccc ttcaattgta tcctgggtct gaacagcgtc
     5341 tgttccaaaa agcgagttct tcttcagacc tattttatcc tcgataataa cagctgatat
     5401 ccctaaacgt tccagcgtgc gaacagtaaa tacaaaatgt tctattttac cacctgtatc
     5461 accatcaaaa attactggtt tggtagtaca ctccaaagca tcattcaaat catgaagacg
     5521 agttgtcaag tcaacggctt caatatcagg cttaccttta gaagtcgaat cagtaagact
     5581 actggaccac atcccatcaa attcacgctt aactccgttg acttctacac tggtattttc
     5641 tattatcaaa cctgttaacc cactatgaga ttcacagata cgaacaatac ttttagcagc
     5701 aattaagcgt ttaagtcgct tcaaacgaat ttcgggagtg gttcctattt ccttcaacct
     5761 agtattcaat aaagtggaag aaataccttt cgtataagga acatctatca cttttccacc
     5821 ccatttagag atagtatcaa tcacacgctg gcgagtttct tgttgaatac cctctttcca
     5881 gtcatcacca tgtactacaa agtcaggcct aatcaattcc aaattcggaa cataatcaag
     5941 agtagtttga ggtattactt catcaacacc cttcaaattc agaactatca atgagcgctg
     6001 atcaaaattc aagtaaggca aacgcttgta actggcaata gctgaatctg ttaatacacc
     6061 aaccgttaca tgccccaatt ttgaagcctc atgaatgata ttcaaatgac ctggatgaat
     6121 aatatcagca ctcatgccga cataaacctt ttttttttcc atttaatttt aatattacga
     6181 atttatgaga ataaacatat tgaaaaaata gcaacaacaa aacataaata attgaggaag
     6241 gcttctgaaa ttcccacgaa aaaatattga acattgatat atagaccaaa tatatcataa
     6301 taccaagagt cagtaatgtt ggtttttgag taaatttata aatactatat cgtacgataa
     6361 agccatataa aaatgggaat aaaagaacgc caacgtaacc aaaatccaaa taatgaaata
     6421 ttatattagt gtatgcataa ttaaagatga ttccattccc aactgaaatt tttgaatttt
     6481 gcaaaagatg acctatttca tcatgagcaa tggtataact tcctcctaaa taatggatta
     6541 caagttttaa taaattatca attccaccca ttgttgccct tccataccaa aacccggtta
     6601 tcgattcata attagctcta aatgaatagt ctaaagctct aaatggacct aaaaaatacc
     6661 atacggcctg actttttagt tcttcaaaac ctatttttac gacctcagca ctaaatgtat
     6721 caaatcccat tctttgagct gtcatatatg aaataaccac aactattatt ccaacgccaa
     6781 cgaacaagca tacaaaagaa actacaccaa aattccattt tttccttttg ctggctaaca
     6841 aattgatata gtacaattct cttcttaaat aataaatgat aaaacaataa aatagaaaaa
     6901 caatcaatcc cccacgccca ttaccaacag atgcgtataa aaacagaaaa agcaccgata
     6961 gcaacagaat tctacgttta atcttagaaa gtagcataca cgctacaatt agcataacaa
     7021 actgtgtaaa aggttttatt agaaaatcat atagatatac ttctaaatta ctcgtaaaaa
     7081 gttcaccagc ctcaaatctc atcatccgac cttcgcccgc tccatatagt tcaataacta
     7141 gagcaaactt cattgcgtaa taataagtaa caatacatgc caacataaga agtaatatca
     7201 tcttattatt gccaataacc agattataaa aactattatc tgttgtaacc ttcaatcgta
     7261 ttttttttat ttttccaaaa caaagaaatc cccaattaaa cgcccaaaca ttgatcaata
     7321 ataacatata tgttttcatt gacacagaat atagttcagc tggatcaaaa gtagaaataa
     7381 caatagcagt tccccaccac aataaatata tgaaacttat ttttcttgaa aaagaatcaa
     7441 ttataagcct attagatatc aaaatctgaa ttaagaatag aataagaaaa attatagcaa
     7501 tcatttgatt ctatactttt gtccctttgt caaccaccag aaagaaacat ataaagcctt
     7561 atagatatct ttcagattct taggaaaata agaaaaagaa tatttcacaa ataaagtaaa
     7621 atgatatata tatttcttta aggaaatgtc aagtgattct gaaaatatag ctctatgaac
     7681 aaatgccaaa tatctgtaat aaggaaattt caaatcttta ttatgaaaat attcaggaac
     7741 ttttaggtct aatacatgta atgaataaga aactctagaa gtaactccca ttgcattctt
     7801 cctataacaa cacattacat ctggcatata taaaatattt cctttcaacg aacaagccaa
     7861 aaacagaaaa cgatctccag catataaact actattgaaa tctttaatat aatcaagtac
     7921 ttctttttta aaaaggaaag acgctgtatg aaaaagtctt acatccaata agtctttagt
     7981 ttttaaaatc tgttttttca catgatgaaa catatgggat ggagttccat tctcataaaa
     8041 aactaaagat tgatgcgcac aacctgctaa cgaatgatca ctctccattg catttacttg
     8101 tttttgtaac ttcaacggat cagtccaata atcatccccc tcacaaagcg caacatattt
     8161 accttttact aaaggaaata atatttgacg taacggagaa ataccttgag aatactggtt
     8221 tcgaatctga agaattggtt taataagatt aggatatgcc acaacatatt cattaataat
     8281 actctgagta gcatcagaag acgcatcatc atgaacaaga atttcaaaat caaattctgt
     8341 tttttgcatt ataaggccat ctaaacactg ccttatatat ttttcatgat tatacgtcaa
     8401 gcaacatatg ctaactgtta ttgaaccgtt catttatttt aatcttaatt cagcaaaacg
     8461 ctttatttcc atttcacttt tataatcctc aaacaactta cgacaatcat attgaggcac
     8521 atatcctaat tctttctttg cattttcaat gttcattatg tacccaccac cacaaacttt
     8581 gtctggtcta tatataactt cagatggtga ctccttaggc gaaaaaacac taataatagt
     8641 gcgaatttgt tcttctaatg taattggcat tcctgtaccc acattataaa agccactttc
     8701 ttgttccacc tcaacagctt tacacaacat ttgactaaaa tcgttaacat gaaccatatc
     8761 ctttgcataa tgaggatctc cccatatctc tataggtagt cctttctgag cattttcaat
     8821 catttggtaa ataggtcgct tcgtcttgac tccattagga aagtagtacg gataagggct
     8881 atagctatat attgttggaa gcctaaaaat gaattttttc aaaccgtatt cttgataata
     8941 atgctctatc aagtctaaag cagtattttt ggaaattaca tatatagcat gatcacccgt
     9001 atagctaaaa tttggtttca tatcgggttt taaaatagta tcatgagaat acaatgaaat
     9061 atcaaaaacg gtttgagtat aaattatcct atctacatga catttgcggc aatactctaa
     9121 tacattaaat cctcctatta caatagaatc taaatacttt atggggcaat aagtatccat
     9181 ataagaaggt atttgagcag agagtagcat aactgcatgt atattttcca ttggaagctt
     9241 atcaaaatct tcttccttcg taatgtccac agaataatat ggtattcccc ttttggaaaa
     9301 aaaagtagtt tcgcgacgtc ctgaagctat tatttcatac tcttccttat taaagaaatt
     9361 taatgcgtat tctaacaaat aagaccctgt attaccggtt gctccaaaaa taataatttt
     9421 ctttttcatg ataaatggtt atttaagtta gatatttttt caattaatat attcattgtt
     9481 ttttcatcat atctctgatc tataggcaat gcaatcatat tattcgcgat tgagtattcc
     9541 agacatttag cgtctatctt attcactacg ttttgccaat attgaggtac atatacgtgc
     9601 tctaatatta attgttggcg aagcccagct ttgctcgtat aaaaaggata tatcaacggg
     9661 acattttgat tttcagaaat actaaaatca aatttattaa atgcagttaa tgcactgtag
     9721 agaagatgat aattaaaacg acgcctttca attattgaga cgtaatccaa agaagacaaa
     9781 attttatcag acaatacaga cattctatgt atctcttgat ttgacatcct ttcttcagat
     9841 tcttgaaaat ctttataata cccctctgca gagtcagtta tacgccctat caagtagtta
     9901 atattatcaa taggattata aatcgggaaa tcaatatcca gtaacgcagt tgtgtacaaa
     9961 taagcgccat ctggaactcc aaaaaattta cgggcagaat aaaatgtatc taccccttca
    10021 attggttttg caaaaaaagc ttgtgcatta tcaactatta agttaggata aaaccgagat
    10081 aaataaagaa cagtatcttg ttttaagccg aaataattag tatatagaaa agcctctgag
    10141 ctttctattt ttttatcaaa cacaggatcc agtaaactat ttatatgata atattcatac
    10201 tttacattta atttcatgag aggttctatt atcacatcac aagtgtaata tggaatatac
    10261 acttttgtat accgtctagc ttttaatata tactcaaagc attgacgagc agtactcagt
    10321 tttattgcac cttgatgaaa atgttctcct tcacgtattt ccagttcaaa atagccacct
    10381 attgacatca ttgtaaacta aatgaatcta ataacataca agtttcttct ttagaattat
    10441 tcattagtac atctattatt gataaatatg gaacaaattc tttagattgc tggggatacc
    10501 tttttattat cgtatctaca aatttcaaat taataccatt ttgcataaag tcttccttat
    10561 tatagatttg ttttccacct atagcattat aataagtatc tgccgatagt aacttacaaa
    10621 tatgaagaac tttatccttt ccttttaaag agcaatcttt aggtaaatct gaagatagca
    10681 atatttcagt ctgaatattt agataatcta aaatttcttt aaaactatta gccaagaaga
    10741 gagccaattg tctatttgga aacataatta tcctatacaa caattccatt gtttcatgat
    10801 agaaaggagc tttagagtaa ttcaattcca atgttttcat aaatttacga aaatcatctc
    10861 ctatctctat ttcattgaaa tgtttatagg cactagcccc cttcaaagtg atagtaaaca
    10921 ttttcttttc accatttacc aatatattgt tacgattcac ccaccctcct ttaatataat
    10981 taacatcatc gtatacaacg tatttatcaa cagccttaat tagctggaaa taacctatat
    11041 aaggcataaa ataaggttgc attataccta atttcatttc aatatcagat ttaaaattct
    11101 ttcaacatct tcattcgaca atccacaata cattggcaag cagattacac tttttgccat
    11161 tt
//
