LOCUS       c00065_gnlPro..        13781 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|OKHBBMGF_65.
ACCESSION   c00065_gnlPro..
VERSION     c00065_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-05 02:30:04
            Original ID  :: gnl|Prokka|OKHBBMGF_65
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13781
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             complement(1..414)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg65_1"
                     /sec_met_domain="OAD_beta (E-value: 4.1e-38, bitscore:
                     121.8, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQESFLSFLGDNLQLFLTYTGVYNATPGHIIMILVGLLFIFLAIK
                     YEFEPMLLIPIGFGILIGNIPFKDAGLQVGIYEQGSVLNILYQGVTSGWYPPLIFLGIG
                     AMTDFSALISNPKLMLIGAAAQFGIFGAYIIALQ"
     protocluster    1..13781
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[0:3781]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      1..3781
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..13781
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..13781
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             complement(419..850)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 63.9; E-value:
                     3e-20)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg65_2"
                     /sec_met_domain="Biotin_lipoyl (E-value: 1.1e-20, bitscore:
                     63.9, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKSFKYTINGNVYKVHINSVVDDIAEVEVNGTPYNVKMEKPAKKQ
                     MVTLKRPAQAPTTASGEPVVTRPAASTTQGAVKTPLPGVILQIKCNVGDTVKRGQTLLI
                     LEAMKMENNINADRDGKIIEIKVHKGDSVLEGADLVVIG"
     CDS             complement(873..1757)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg65_3"
                     /sec_met_domain="OAD_gamma (E-value: 3e-12, bitscore: 37.7,
                     seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTNKRFGVLLLFILLVSFGAQAQRATSMRINEVLVINEDNFVDDY
                     GKRHGWIELFNTSAGTVNIAGCFLTDDKNNPKKYPIPKGDVLTQIPPHQHTLFWADGEP
                     NRGTFHVNFTLDPSKENYIALYDADGKSLIDEITIPAAQKPDVSYGRIIDGKEEWAQLT
                     KVTPSTNNLTLDSNEKIENFKTNDSLGIGMTITAMAVVFLGLLLLFLIFKQVGKAAIAA
                     SKRNAQKAGAPVNVNTPDEVSGEVFAAIATALYEMSDDNHDIEHTVLTIRKVRRAYSPW
                     SSKIYSLRETPRK"
     CDS             complement(1780..3333)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Btheta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg65_4"
                     /sec_met_domain="CT_Btheta (E-value: 1.9e-292, bitscore:
                     960.5, seeds: 72, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNQLEKVKELIALREQARLGGGEKRIESQHKKGKYTARERIAML
                     LDEGSFEEFDMFVQHRCTNFGIEKTKFLGDGIVTGYGTIDGRLVYIFAQDFTVFGGALS
                     ESLAMKICKVMDQAMKMGAPVIGLNDSGGARIQEGVNALAGYAEIFQRNILASGVVPQI
                     SGIFGPCAGGAVYSPALTDFNIMTRGTSYMFLTGPKVVKTVTGEDVTQEQLGGASVHTT
                     KSGVAHFAVDTEEEGLQLIRKLLSFLPQNNLEETPLIECKDPIDRLDDVLNDIIPDNAN
                     QSYDMYEVIGTIVDNNEFLEVHADYAKNIIVGFARFNGQSVGIVANQPKVMAGCLDSNA
                     SRKAGRFVRFCDAFNIPLVTLVDVPGFLPGTGQEYNGVILHGAKLLYAYGEATVPKITV
                     TLRKSYGGAYCVMSSKHLRGDMNYAWPTAEIAVMGPSGAVEVIFAKEVAASEDPAKATA
                     EKEAEYKKAFANPYNAAQYGYIDDVIEPRNTRFRIIRALQQLQTKKLSNPAKKHDNLPL
                     "
     CDS             complement(3371..3781)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Glyoxalase_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg65_5"
                     /sec_met_domain="Glyoxalase_4 (E-value: 2e-27, bitscore:
                     86.3, seeds: 51, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEITHIEHLGIAVKSIEACLPYYEEILGMKCYNIEEVADQKVKTA
                     FFKVGQTKIELLEPTSEDSTIAKFIEKKGEGIHHIAFAVPDVQAALDEAESKGVKLIDK
                     APRGGAEGLNIAFLHPKSTCSVLTELCMPGKK"
     CDS             complement(3982..4896)
                     /locus_tag="ctg65_6"
                     /transl_table=11
                     /translation="MFTLIGGIRGSYWSYNKEFIFSPRVSLGFIPNFDQNLTFRAATGI
                     YYQSPFYKELRTTVQDAAGNDIIELNKDIKSQRSIHFILGGDYTFRAADRNFKVSADLY
                     YKKLDDLIPYTVDNVKIRYYGENCAKGHAMGIDVKFFGEFVPGTDSWISFSLMKAEQTI
                     RDMVTVPMPNSQGYNVSLFFQDYFPGYKRVKLNLKGVLSGGLPFIAPRTKYEDVKSTFR
                     TPAYKRVDLGFSYQLAGGTDAIMDRGVFRHLKNIWIGVDVFNLFDIKNVSSYYWITNID
                     NQQYAVPNYLTGRQLNARLIVDF"
     CDS             complement(4992..6389)
                     /locus_tag="ctg65_7"
                     /transl_table=11
                     /translation="MKIRAIAALLFILVSISAFGQKHVKITGYVRDADGSPLELVLVQI
                     KNTLNGAMTNEKGYYSISTSPGDSVAVIFSCLGYNKAERILPSLQQDMRLNVQMNYTSI
                     DLGEVVAVGTRYQTSTLQTMNADRVKLLPDPAGGSIESLVVTFAGVSSSNELSSQYSVR
                     GGSYDENIVYVNGLEVFRPLLIRSGQQEGLSFITEAVNFAAGGFEARYGDKMSSVLDIT
                     YKKPKLFEGSASASLLGANAYVGSSIGKFTQITGVRYKTGRSLLKTMDTDAEYQPDFVD
                     LQSYMTYQLAPKWEVNFLGNLASNTFKFTPHKRETNFGTVENAQRFEVYFPNSRERDKF
                     QTIFGALTLKHNPNEKTELGLQASAFSSKEIETYDITGEYWLGDATTENDNNQNALEIA
                     RYHEHARNRLSSTIMNVGHYGSSKIKNNTLKWGATVQMXXXXXXXXXXXXXNATRQVTH
                     FLKQGTG"
     CDS             6536..7090
                     /locus_tag="ctg65_8"
                     /transl_table=11
                     /translation="MESFATLIKNRRSTRKFTDQLLSPEQVEMILKAALMAPASKRKNP
                     WQFVVVEDKEMLKKLAGCKPAGASFLEGCALAVVVMANVMDSDVWVEDASIASIYMQLQ
                     AEDLGLGSCWCQIRNRQTEDDADANVYVRSLLDIPYQLEVLSIIGFGYKDQERKPFDEA
                     HLQWEKIHLGTYKMPEENKEA"
     CDS             7087..7854
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) F420_oxidored"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg65_9"
                     /sec_met_domain="F420_oxidored (E-value: 6.1e-09, bitscore:
                     27.1, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIVFIGAGNLATRLSLAMQRVGMQIGQVYSHTEASARQLATRLG
                     CPWTNDLSALQEDGDLYVFSLKDTVLSDVISKVKPNNGMWVHTAGSMPMSVFEGYAQRF
                     GVLYPLQTFSKGRNVNFDVIPVFLEANTDKNADYLKNIASALSENVRFMSSEKRRSLHL
                     AAVFACNFTNHIYTLSYKLLENESIPADVLLPLIDETVSKIHSMPPAAAQTGPAIRYDE
                     NVINKHLAMLDDPDMQAIYRLLSQSIHKEAQNE"
     CDS             7847..8368
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HAD_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg65_10"
                     /sec_met_domain="HAD_2 (E-value: 3.5e-10, bitscore: 30.8,
                     seeds: 51, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSINYDLTKIKAFVFDVDGVLSCDVVSLHPNGDPMRTVHIKDGY
                     ALQLAVKKGYQVGIITGGYTEAVQIRFSRLGIEHIYMRSAVKIHDFNDFLQKTGLTPEE
                     VMYAGDDIPDYDVMKRVGLPVAPADAAPEIKQIAKYISLCKGGEGVARDVIEQTMKAQG
                     HWMSAEAFGW"
     CDS             8387..8752
                     /locus_tag="ctg65_11"
                     /transl_table=11
                     /translation="MLTNLQHYRIVLGSNSPRRKELLAGLDLKFEVEVIPGIDESYPDD
                     LTADEIPAYIARKKAEAYLEKMTDNELLITADTIVVTYXXXXXXXVSWANRPTVRKQSR
                     CFATCRAMYMKSSPAFA"
     CDS             8698..8985
                     /locus_tag="ctg65_12"
                     /transl_table=11
                     /translation="MLCHLSGHVHEVITGVCLTTKQKTVSFSVSSAVAFSKLEKDDIIY
                     YVDKYRPYDKAGSYGIQEWIGYVGVEAINGSFYNVMGLPVQRLYQELKKF"
     CDS             9361..10320
                     /locus_tag="ctg65_13"
                     /transl_table=11
                     /translation="MNIPAQYNGQTIKSLGGIENFAYLEQLTCSDNTELTSLDLSKCSY
                     LKKADCHNCNISSLNLSGCSRLEELYCYSNSLNELNLSDFESLAYLYCDFNVLTSLDFT
                     NNPDLKEISCSGNKLQGDLNLSKCTKLEALLCEKNSIELIDITECTSLKTLICYSNKLT
                     AIDVYSKALEILSCSGNDISWLHVANCENLQELYCSENPSMQILGIKGCVSLKTLECYS
                     NNLSSLNMSDSKDLTHIDCHNNVLSSITLNSTLITYLDVSQNLLQTLDISLCPAIKCLY
                     FTLNRPLNNGGVSKLRHISFFILKIVVPLFLSMRLFLQ"
     CDS             complement(10298..11455)
                     /locus_tag="ctg65_14"
                     /transl_table=11
                     /translation="MDKIRILLEQVDEAIAQENSTKDTPVEFTPAMLSDIVNELKEVLE
                     HQPVTKDKEQKKVIREKKKQVRELEEHRDKLMEYDNHLDTLGERNSYSKTDPDATFMRM
                     KEDAMRNGQTKPGYNLQIGTQNQFLIDFRLFPNPTDTLTLIPFFHSFEQRYNRLPTVGV
                     ADSGYGSEENYRFMQDNGIEAFVKYNYFHKEQRPRYTPNPFHAESLHYNAEEDYYVCPM
                     GQHMNRIGTRSDKTASGYITESARYKAQRCEGCPLRGSCFKARGNRIIEVNHRLNQYKR
                     LARERLLSKEGFRHRGRRCIEPEAVFGQMKHNMAYKRFRHVGEDKVTMDFAFFAIAFNI
                     KKMCTKLLKAGKRRSTHIIFIFIRPRVAQHTRNIKPYLITEEIVA"
     CDS             complement(11520..11954)
                     /locus_tag="ctg65_15"
                     /transl_table=11
                     /translation="MAKLHFRPYIPNQTVLFPGRIDENIAANDPVRIVNTVVDNLNLDN
                     FKKLYKATGRCPYHPKMMLKVIIYAYMNNIYSCRKIEKLLLRDIHYIWLSGNEHPDFIT
                     INRFRNRVKEEINNVFTQLVLVLVDKGFISLDIEYRRYQD"
     CDS             11968..12075
                     /locus_tag="ctg65_16"
                     /transl_table=11
                     /translation="MPKDTKTLGNNKAWACESLGFVHKKRLCQRFDTTS"
     CDS             12231..12671
                     /locus_tag="ctg65_17"
                     /transl_table=11
                     /translation="MKRMIPLVLLVVFTACNNSFIDEKVSVDEVSELVDSATIAAESXX
                     XXXDVIPIMATSTKAEYEAIRLVNNPDSTNLVTVKEYSISTPLTKAGDYTIIKVEYNWI
                     EDMTYVTMQGVTNHEIVLNKTAVTISESVANKWGIDPCILGN"
     CDS             12653..12958
                     /locus_tag="ctg65_18"
                     /transl_table=11
                     /translation="VYSWKLTLVYNQSRSHEFVIGDYAGVKPSDENSYGYDLVQTGSNQ
                     WTVSTIYYRYEKRSIGPNSDSVIGVYCIPVYSLNEPGVDFNTFKWQYTLQGDYSSK"
     CDS             13320..13637
                     /locus_tag="ctg65_19"
                     /transl_table=11
                     /translation="MYVIVEINGQQFKAEEGKKLFVHHIQNAESGAVVEFDKVLLVDNN
                     GEVKVGVPTVEGAKVVCEVLSPLVKGDKVLIFHKKRRKGYRKLNGHRQQFTEVSIKEIV
                     A"
ORIGIN
        1 ctgaagagcg ataatataag caccgaagat accgaactgg gcggcagcac cgatcaacat
       61 cagctttgga ttggaaatca aagcggagaa gtcggtcatc gccccgatac cgaggaagat
      121 caacggcgga taccatccgg aggttacccc ttgatagagg atgttaagta cagacccttg
      181 ttcgtagata cctacctgaa gccctgcatc tttaaaagga atgttaccga tcaggatacc
      241 gaatccgata gggatcagca acatgggttc aaattcatat ttaatcgcaa ggaatataaa
      301 gagcaaacca accaatatca taatgatatg gcccggagtt gcattatata ctcctgtata
      361 ggtgaggaac aactgtaggt tgtcacccag gaatgataaa aaactctctt gcatactctt
      421 atccgattac gacgagatca gcaccttcca gtacggagtc tcccttatgt actttaattt
      481 caataatctt accgtcgcgg tcagcgttga tgttgttttc catcttcata gcctcgagga
      541 taagtaaagt ttgtcctctc ttcacagtgt cgcctacatt gcatttgatt tgcaggataa
      601 cacctggaag cggagtttta acggcgccct gggttgtaga tgctgccgga cgagtaacaa
      661 ccggttcgcc gctggctgta gtaggagcct gtgccgggcg tttgagtgta accatttgtt
      721 ttttcgccgg tttctccatt tttacattat aaggagtacc gtttacttct acttcagcga
      781 tatcgtcgac cactgaattg atgtgtactt tatatacgtt accgttgatg gtatatttaa
      841 aacttttcat tcttgtttgt ttttagagat aatcactttc tgggagtttc acgtaaacta
      901 tagatcttag aactccatgg agaatatgca cggcgaactt tgcggattgt aagcactgta
      961 tgttcgatgt cgtgattgtc atcactcatt tcatacaaag ctgtagcgat tgctgcaaaa
     1021 acttcgcccg aaacttcgtc cggtgtattt acattaacag gtgcccctgc tttctgagca
     1081 ttacgtttgc tggctgcgat agctgctttt ccgacttgtt tgaagatcag gaaaagaagg
     1141 agcaagccta gaaaaacaac agccatagct gtaatagtca taccgatacc caaagagtca
     1201 tttgtcttaa agttttcgat cttttcgtta gaatctaacg tcaggttgtt tgtgctggga
     1261 gtcacttttg tgagttgtgc ccattcttct tttccgtcaa taattctacc atagctaaca
     1321 tccggttttt gtgcagccgg aattgttatt tcgtcgatca aggatttacc atcggcgtca
     1381 taaagtgcta tataattttc ttttgacggg tctaacgtga aattgacatg aaaagtacca
     1441 cggttaggtt caccatccgc ccagaacaga gtgtgttgat ggggggggat ctgagttagt
     1501 acgtcaccct tggggatcgg atatttttta ggattgttct tgtcgtctgt caagaaacaa
     1561 cctgcaatat taaccgttcc ggcagaagta ttgaataatt ctatccagcc gtgacgtttg
     1621 ccatagtcgt caacgaaatt atcttcgttg atgaccagca cttcatttat tcgcatggag
     1681 gttgcacgct gtgcctgtgc cccgaatgat acgagcagga tgaacagcag caatactcca
     1741 aatcttttgt tagtcatatt cattttcctg ttttaagaat tatagaggca gattgtcatg
     1801 tttcttagca ggattgctta actttttcgt ctgcaattgt tgtaaagcac gaatgatacg
     1861 gaaacgggta ttacgcggtt cgatcacatc gtcgatataa ccgtattgag ctgcgttgta
     1921 cgggtttgcg aatgctttct tgtattctgc ttctttttcg gctgttgctt ttgcaggatc
     1981 ttcggatgcg gcaacttctt ttgcgaagat aacttctaca gcaccgctcg ggcccataac
     2041 tgcgatttct gctgtcggcc atgcgtagtt catatcgcca cgcaggtgtt tagaactcat
     2101 cacgcagtaa gcaccaccgt aagatttacg caatgtaaca gtgattttag gcacagttgc
     2161 ttcgccgtaa gcgtaaagca atttggctcc gtgaaggatt acaccattgt attcctggcc
     2221 tgttcccgga aggaatcccg gtacgtctac caatgttacc aaaggaatgt tgaaagcgtc
     2281 gcagaagcga acgaagcggc ctgccttacg ggaagcgttg ctgtccagac agcctgccat
     2341 tactttcggc tggttagcta cgataccaac agactggccg ttgaaacgtg cgaaaccaac
     2401 aataatattt ttagcataat cagcatgtac ttccaggaat tcgttgttgt caacgattgt
     2461 gccgattact tcatacatgt catatgactg gttagcgttg tcaggaatga tgtcgttcaa
     2521 tacatcgtcc agacggtcga tcgggtcttt gcattcgatc agcggagttt cttccaggtt
     2581 gttctgcgga aggaagctga gcaatttgcg gatcagttgc agaccttctt cttctgtgtc
     2641 gacagcgaaa tgggcaacac ccgatttggt tgtgtgtacg cttgcgccac ccagttgttc
     2701 ctgagttacg tcttcaccgg taacggtttt tactactttc ggacctgtca ggaacatgta
     2761 gctggtacca cgtgtcatga tgttaaagtc agtcagcgcc ggagaataaa ctgcgccacc
     2821 tgcacacgga ccgaagatac ctgaaatctg aggtacaaca ccggatgcaa ggatattacg
     2881 ctggaagatt tcagcatatc ctgccagagc gttaacgcct tcctggatac gtgctccacc
     2941 tgagtcgttc aagccgatga caggggcacc catcttcatg gcctgatcca ttaccttaca
     3001 aatcttcatg gccagtgatt ctgacaaagc tcctccgaat acggtgaagt cctgtgcgaa
     3061 gatgtagacc aaacggccgt cgatcgtacc atatccggtt acgataccat cacccaggaa
     3121 ttttgttttt tcaataccga agttagtaca acggtgctga acgaacatat caaactcctc
     3181 gaaactacct tcgtcaagca acatggcgat acgttcgcgt gctgtgtact tgcctttctt
     3241 gtgctgagat tcgattcttt tttctccacc acctaaacgg gcttgttcgc gaagagcgat
     3301 aagctctttt actttttcaa gttggttact cattgtattt ctgatttgtt gttagaaatg
     3361 aactgattaa ttatttttta cccggcatgc aaagttcagt caatacgctg caagttgatt
     3421 tcgggtgaag gaatgcaatg ttcagacctt ctgcaccacc gcggggagct ttgtcgatca
     3481 gtttgacacc ttttgattca gcttcgtcca atgcagcctg tacatcaggt acagcaaatg
     3541 cgatatggtg aataccttcg cctttctttt cgatgaattt ggcgatagtg ctgtcttcgc
     3601 tggtcggttc aagtaattcg atttttgttt ggcctacttt aaagaacgca gtctttactt
     3661 tttggtcagc aacttcttcg atgttgtagc atttcatgcc taaaatttct tcataatacg
     3721 gcagacaagc ttcgatgctt tttactgcaa ttcccagatg ttcaatatgt gtaatttcca
     3781 tgtcaataag aatttaataa ttgataaatg ctttttgttt tgatggcaaa ggtacattct
     3841 ttttgaagaa tcaagaaata tttcattaat aataatttgc caatttgcca atatgcaaaa
     3901 ttgccaatga aagccttgac ttctcattgg caaatcctgt tttttatcgg catattggca
     3961 aattatctta ttggcatatt tttagaaatc gacaatcagt cgtgcattga gttgtcggcc
     4021 tgtcaggtaa ttcggtacag catattgctg gttgtcgatg ttggtgatcc agtaatagga
     4081 actgacattt tttatatcga acaggttaaa tacgtccact ccgatccaga tatttttcag
     4141 gtgacgaaag actccgcggt ccatgatcgc atcggttcct ccggccagct ggtaagagaa
     4201 accgaggtcg acacgtttgt aggccggcgt gcggaaagta ctcttcacat cttcgtattt
     4261 cgtgcgtggt gcaataaaag gaagtccgcc ggagaggacg cctttcagat tcagttttac
     4321 acgtttgtat ccgggaaaat aatcctgaaa gaataacgat acgttatatc cctggctgtt
     4381 gggcatggga acggttacca tgtcacggat tgtttgctct gctttcataa gcgagaagct
     4441 gatccatgaa tcggttccgg gtacaaattc accgaagaat ttaacatcga tacccattgc
     4501 atggcctttg gcacagttct ctccgtagta ccggatcttt acgttgtcga cggtgtaagg
     4561 aatcaggtcg tccagtttct tgtaatagag gtcggcactg actttaaagt tacggtcggc
     4621 tgcccggaac gtataatcgc caccgagaat gaaatggatg gaacgttgcg atttgatatc
     4681 cttgttcagt tcgataatat cattgcctgc ggcatcctgc acggtggttc gtaattcttt
     4741 atagaacggt gactggtagt agatacctgt cgctgcacga aaggtcagat tctgatcgaa
     4801 attagggata aaacctaaag aaacgcgtgg gctgaaaatg aattctttgt tatagctcca
     4861 gtagcttccg cggataccgc cgatgagtgt gaacatacct tgcttggtac ggaacttgaa
     4921 aacgtcctgc aaatatcccg atatccgggt agtcgacaaa tcattgtccg aataaagatt
     4981 ggagatcacg tttaccccgt tccctgtttg aggaagtgag taacctgccg agtcgcgttt
     5041 tnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnncca tctgtacggt ggctccccat
     5101 ttcagcgtgt tgtttttgat cttgctactg ccgtaatgtc ccacattcat gatggttgaa
     5161 cttaaacggt tgcgggcatg ctcatggtag cgggctattt caagggcatt ctggttattg
     5221 tcgttttctg ttgtagcatc gcccagccag tattcgccgg tgatgtcata ggtttctatt
     5281 tccttgctgg agaaagcgga tgcctggagg cccagttctg ttttctcgtt cggattgtgt
     5341 ttcaaggtca gtgcgccgaa gattgtctgg aacttatccc gctcgcggct gttggggaaa
     5401 tacacttcaa accgttgggc gttttctacc gtaccgaagt ttgtctcccg tttatgcggg
     5461 gtgaatttga acgtgttgga cgccaggttc cccagaaagt ttacttccca tttcggagct
     5521 aactgataag tcatgtatga ttgcagatcg acgaaatccg gctggtattc ggcgtccgta
     5581 tccattgttt ttagtagcga acgtcctgtc ttataacgaa caccggttat ttgtgtgaac
     5641 ttgccgatgg aactgcccac ataggcgttt gctcccagta agctggcgga ggccgatcct
     5701 tcaaataact tgggtttttt ataggtgatg tcaagaacag agctcatttt atctccgtac
     5761 cgtgcttcaa atcctccggc tgcgaagttg acagcttcgg tgataaagct cagaccttcc
     5821 tgctggccgg aacggatcag taacgggcgg aatacttcca ggccgtttac atatactatg
     5881 ttttcatcgt aactaccgcc gcgaaccgaa tactgggaac ttaattcgtt gctggatgaa
     5941 actccggcaa aagtgaccac gagactttcg atgcttcctc cggcagggtc ggggaggagc
     6001 ttgacacggt ctgcattcat ggtttgaagg gtactggttt ggtaacgggt acctacagca
     6061 acaacttctc ccaggtcgat acttgtgtag ttcatctgta cattcagccg catgtcctgt
     6121 tgcaaactgg gtagaatacg ttctgcctta ttatatccca gacaagagaa aataaccgct
     6181 acggaatcgc ccggcgacgt ggagatcgaa tagtaaccct tttcattggt cattgccccg
     6241 ttcagcgtat tctttatctg aacaagcaca agttcaagcg gactaccgtc ggcatcccga
     6301 acatatcccg tgattttaac atgcttttgt ccaaaagcgc tgattgaaac taatataaat
     6361 agcagtgcag ctatcgcacg aatcttcata attaataatg ttatagcttt actaacgcga
     6421 aaaatgaagg aagcgtatat tcagcgtgta aaaaaatatt tatctttgtc ctgttcagaa
     6481 atatcttcct tacagaatga agatgattaa ttaacagcta caaaataaga taaaaatgga
     6541 gagttttgca acactgataa agaatagaag aagcacgcgt aagtttaccg accagttgct
     6601 ttcacctgaa caagtcgaaa tgattttaaa ggcagctttg atggcacccg cttccaagcg
     6661 taaaaatccc tggcagttcg ttgtggtgga agataaggaa atgttgaaaa aactggctgg
     6721 ttgtaagccg gccggagctt cgtttcttga aggttgtgca ctggctgttg tggtaatggc
     6781 gaatgtaatg gatagcgatg tctgggtgga agacgcctcg atcgcttcta tctatatgca
     6841 actccaggcg gaagatctgg gtctgggcag ctgttggtgc cagatacgta accggcagac
     6901 ggaagatgat gcagacgcca atgtgtatgt ccgtagcctg ctggatattc cttatcagct
     6961 ggaggtgctc tcgattatcg gtttcggtta taaggatcag gaacgcaaac cgtttgacga
     7021 agctcatttg caatgggaaa agattcacct gggcacttat aaaatgccgg aagaaaacaa
     7081 ggaagcatga aaatagtttt tatcggagcc ggaaatctgg cgacacgttt gtcgctcgcc
     7141 atgcaacggg ttggtatgca gattggtcag gtgtacagcc atacagaggc gagtgcccgt
     7201 cagttggcaa cacgactggg gtgtccgtgg acgaatgatt tatccgcttt gcaggaagat
     7261 ggcgatctgt atgtcttttc actgaaggat actgtcttgt cggatgtaat atcgaaggtc
     7321 aaaccgaata acggtatgtg ggtccatacg gcaggaagta tgccgatgag cgtatttgaa
     7381 ggatatgccc aacgtttcgg agttctttat cctttgcaga cattcagtaa ggggaggaat
     7441 gtgaattttg atgtgattcc tgtttttctg gaagcaaaca cggataagaa tgcggattat
     7501 ctgaagaata tagccagcgc tctttctgag aatgttcgtt tcatgtcttc ggaaaaacgc
     7561 cggagtttgc atctggcggc tgtctttgcc tgtaatttta ccaatcatat ttatacatta
     7621 tcttataagt tactggaaaa cgaatccatt ccggcagatg tccttttgcc gcttatcgat
     7681 gagacagtat cgaaaataca ttccatgccg cctgctgcgg ctcagaccgg gccggcaatc
     7741 cggtatgatg aaaatgtgat caataaacac ctggctatgc tggacgatcc ggatatgcaa
     7801 gcgatctacc ggcttcttag ccaaagtata cataaggagg cccaaaatga gtagtatcaa
     7861 ttatgacctg acaaagataa aagcatttgt gtttgacgta gacggtgtgc tgtcgtgcga
     7921 tgtggtatca cttcatccca acggtgatcc gatgcgcaca gtccacatca aagacggtta
     7981 tgccttgcaa ctggctgtaa agaaaggtta ccaggtcggg attattaccg gtggctatac
     8041 ggaggctgtg caaatccgtt tttcccgctt gggtatcgaa catatatata tgcggagtgc
     8101 cgtaaagata cacgatttca atgatttcct gcaaaagacg ggattgacgc ctgaagaagt
     8161 catgtatgcc ggagacgata tccccgacta tgatgtgatg aagcgggtag gcttgccggt
     8221 tgctccggcg gatgcagccc cggaaatcaa gcaaatagcg aaatatatct ccttatgcaa
     8281 agggggtgag ggtgttgccc gcgatgtgat agaacaaaca atgaaagcac aaggccattg
     8341 gatgagcgca gaagcgttcg gatggtaata acaatgaaaa ataattatgc tgactaacct
     8401 acaacattac cgaatcgtgc tgggatctaa ctcaccccgg cgaaaagaat tattggccgg
     8461 acttgacctc aaattcgagg tcgaagtaat tcccggtatc gacgaatcat atcctgatga
     8521 cttgacggca gacgagatac ctgcttatat cgcccgtaaa aaggcagaag cgtatctgga
     8581 aaaaatgact gataacgaat tgctcattac ggctgacaca atcgttgtca cttatgnnnn
     8641 nnnnnnnnnn nnnntcgtat cctgggcaaa ccggccgacc gtgaggaagc aatcgagatg
     8701 ctttgccacc tgtcgggcca tgtacatgaa gtcatcaccg gcgtttgcct gacgactaaa
     8761 cagaaaacgg tttctttttc cgtctcttcg gcagtcgcct tttccaaact ggaaaaggat
     8821 gacattatct attatgtaga taaatatcgt ccgtatgata aagccggcag ttacgggata
     8881 caggaatgga tcggttacgt cggggtagaa gctatcaatg gctcattcta taatgtaatg
     8941 gggttgccgg tgcaacggtt gtatcaggaa ttgaaaaagt tttaagcgtt gtttccttgt
     9001 gaaaatattt agtgaacgat ggggctgatt tatgggcatg gccgataaat taagctgcct
     9061 catcgactga tatgtcccgt tggcggattt tattttgatt atctgaaaac atatgagata
     9121 tttgttcgta ttgaaatatg aacaatatta aatttcagat aaaatgaaaa acacaattat
     9181 ccttattcta cnnnnnnnnn nataattatt ttaggaatag tatcttcgtg tgagaagaat
     9241 gaagaaggca taacatttgt tgatttttct gacaatgttt tctatgaatg gtgtcttagc
     9301 tcttttgact tggacggaga tcaagaatta tcgtttcggg aactttatct cgtaacagaa
     9361 atgaatattc ctgctcagta taacggacaa acaataaaat cgttaggtgg gattgaaaat
     9421 tttgcatacc tggaacaatt aacatgtagt gataatacgg aattgacttc attagatctc
     9481 agtaagtgtt cttatttaaa aaaagcagat tgccataatt gtaatatttc ttcacttaat
     9541 ctgagtggat gcagtcgact ggaagagtta tattgttata gtaattcttt gaatgaactc
     9601 aatctttccg attttgaaag tttagcgtat ttgtattgtg atttcaacgt actgacatct
     9661 ttggacttta caaacaatcc cgatttgaaa gaaatttctt gttcaggaaa taaattgcaa
     9721 ggagatctta atttaagtaa atgtactaaa ctggaagctt tgctttgtga aaagaattct
     9781 attgaattga tagatataac agaatgtaca tcgttaaaaa cattgatttg ttattcaaat
     9841 aaacttaccg ctatcgatgt ttattcaaag gctttagaga tattgtcctg ttccggaaat
     9901 gatatatcct ggttgcatgt tgcaaactgt gagaatttac aggaattgta ttgttctgaa
     9961 aatccatcaa tgcaaatcct aggaattaaa ggctgtgtgt ccttgaaaac attggaatgc
    10021 tattcaaata atttgtcatc gttgaatatg tctgattcca aagatcttac acatattgat
    10081 tgtcataata atgttttatc ttccattact ttaaactcta ctctgatcac ttatttagat
    10141 gtatcacaaa atctgcttca aacgttggat atttcattat gtcccgccat caaatgtcta
    10201 tattttactt tgaatcgccc tttgaataat gggggtgtgt caaaactaag gcacatctcc
    10261 ttttttatct taaaaatagt cgttcctctt tttttgtcta tgcgactatt tcttcagtaa
    10321 ttaggtaagg cttaatattc ctcgtatgtt gagccacacg tggtctgata aagataaata
    10381 taatgtgtgt actccttctc tttcctgctt ttaatagttt tgtacacatc tttttgatat
    10441 taaaagctat agcaaagaag gcaaagtcca ttgtaacctt gtcttctccc acatgccgga
    10501 accttttgta tgccatgttg tgtttcattt gtccaaaaac tgcttccggt tctatacatc
    10561 gccttcccct atgcctgaag ccttctttcg agagtaacct ttcccgtgcc agccgtttgt
    10621 attggtttaa tcggtggttg acttctataa tacggttccc ccgggcttta aagcaactac
    10681 cacgtaaagg acacccttca catctttgtg ctttataccg ggcactttcg gtgatgtatc
    10741 cgctagctgt tttgtcactc ctggttccta tacggttcat gtgctgcccc ataggacaaa
    10801 cgtaataatc ctcttccgca ttgtaatgga gactctccgc atggaatgga ttgggggtat
    10861 aacggggacg ctgttcttta tggaagtagt tgtacttgac aaaggcttct atcccattat
    10921 cttgcatgaa tcggtaattt tcttccgagc cgtaaccgga atctgccaca ccgacagtcg
    10981 gtaagcggtt atagcgttgc tcaaaggagt ggaagaaagg tatgagggtc agtgtatcgg
    11041 ttggattggg aaacagtcgg aagtctatga ggaattggtt ctgggtacct atttgcagat
    11101 tatatccggg cttggtctgc ccgtttctca tggcgtcttc tttcatgcgc atgaaggtgg
    11161 catcaggatc ggtcttggaa taggagttgc gttctccaag agtgtcaaga tggttgtcgt
    11221 attccatcaa cttgtcacgg tgttcctcaa gttcccggac ttgtttcttc ttttcccgga
    11281 tgactttctt ttgttccttg tcctttgtta caggctggtg ttccagcacc tctttaagtt
    11341 cattcactat atctgagagc atggcgggag tgaactctac gggtgtgtct ttggtggagt
    11401 tctcttgggc tatggcttca tccacctgct ccaggagaat gcggatctta tccatcagct
    11461 ttgtacggtt cttttcgact gtcttgcgcc agacaaaagt atatttgttg gctctggact
    11521 caatcttggt accgtcgata ttctatgtca aggctgatga aacctttgtc gacaaggaca
    11581 agaaccaact gcgtgaatac attatttatc tcttctttta cacgattacg gaaacggttg
    11641 atggtaataa aatccggatg ttcattaccg gaaagccaga tataatgaat gtcacgtagg
    11701 agaagcttct ctattttgcg gcacgaatag atattgttca tgtaggcgta gataatcacc
    11761 ttaagcatca ttttaggatg ataaggacaa cgaccggttg ctttataaag cttcttgaaa
    11821 ttgtcaagat tgagattatc aacaactgta ttaactatgc gaaccggatc attcgctgct
    11881 atgttttcat caattcttcc gggaaaaaga actgtttggt tgggaatgta aggacgaaaa
    11941 tgtaactttg ccataatgaa aaactttatg cctaaagata caaaaacttt gggtaataac
    12001 aaagcctggg cttgtgaaag tctgggcttt gtgcataaaa aaaggttgtg ccagcgtttt
    12061 gacacaacct cgtaacaaat ttgcgtaatg taaatgggga agctatagat ttaggtggcn
    12121 nnnnnnnnnn nnnntaaatc tgtattacaa tataaataat gatttataga tattcaatat
    12181 caatttgctt ttgtaaatag tattagtatt gttattaatt agaatgtatt atgaaaagaa
    12241 tgattccctt agtgttatta gttgtgttta cagcttgtaa caattcattt attgatgaaa
    12301 aagtatcagt tgatgaagtt tctgaacttg ttgattctgc aacaattgct gccgaatcnn
    12361 nnnnnnnnnn nnaagatgtt atccctatta tggcaacatc gacaaaagct gaatatgaag
    12421 cgattcgctt agttaataat ccagattcga ctaatttagt tactgtcaaa gaatatagta
    12481 taagtacacc tcttacaaaa gctggtgact atactattat caaggttgag tataattgga
    12541 ttgaggatat gacttatgtt accatgcaag gtgttactaa tcatgaaatt gtattaaaca
    12601 aaacagctgt taccatcagt gaaagtgttg caaataaatg gggtattgat ccgtgtattc
    12661 ttggaaactg actttggttt acaatcaatc aagatcacat gagtttgtaa taggtgatta
    12721 tgcaggagtc aaacctagtg atgaaaattc ttatggttat gatttagtgc aaacgggaag
    12781 taatcaatgg actgtttcta ctatatatta tcgttacgaa aagcgtagta ttggtccaaa
    12841 ttcagatagt gttattggtg tctattgtat tcctgtatat tcattgaatg agccgggggt
    12901 agattttaat accttcaaat ggcaatatac tcttcaagga gattattcat caaagtgaat
    12961 gtttttaagg aaaaagaagg ttgaataaag ttctaaagta aacaatttga tataatagtc
    13021 ttattgttta ctttaggact tattgatatt gttgtgtatt tataatactt tggtagtagc
    13081 ttaacgtaaa agagtgttta aaaggtatga aaccataggt ctgttgttgc gtataatttg
    13141 tatttataat aaagtggttt tcttcttaga taggaaataa tcgaaaaaaa acgaatattt
    13201 cttgcataat atattcggaa acagtacttt tgcagtctga aattccgcag agggtaaaca
    13261 agtgatatgg aatatgtatc cacccccggg acataacctg tttaaatata aaaagacaga
    13321 tgtacgtaat cgtagaaatt aacggacaac agttcaaagc tgaagaaggt aagaagttgt
    13381 tcgttcatca cattcagaac gcagaaagcg gtgctgttgt tgagtttgac aaagtgttgt
    13441 tggttgacaa caacggagaa gttaaagtag gtgttcctac agtagaaggc gcaaaggtag
    13501 tatgtgaagt actgtctccg ctggtaaaag gtgataaagt gctgatcttc cacaagaaga
    13561 gaagaaaagg ttatcgtaaa ctgaacggtc accgtcagca gttcactgaa gtgagtatta
    13621 aagaaattgt tgcttaacgt ttaaaggaga aaagaagaaa tggcacataa gaaaggtgtg
    13681 ggtagttcaa agaacggccg tgaatcacaa agtaaaagat taggtgttaa gctttttggt
    13741 ggtgaagttg ctaaagctgg taacattttg gttcgccaga g
//
