LOCUS       gnlProkkaIMPIMKPL_36   13065 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|IMPIMKPL_36.
ACCESSION   gnlProkkaIMPIMKPL_36
VERSION     gnlProkkaIMPIMKPL_36
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-18 00:44:35
            Original ID  :: gnl|Prokka|IMPIMKPL_36
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13065
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13065
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[9113:9467]"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      9114..9467
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..13065
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..13065
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             2..940
                     /locus_tag="ctg36_1"
                     /transl_table=11
                     /translation="MENLNKRERIIPPVPVSTEWPLAIPKMKDSIHKYPIPSPFTGQTI
                     TNRQMAFASSPSLMPPTRKKKSRKWKLMLAGSLGPQLAQNLYKLIATPHTDGISSDFPQ
                     QVSTWEEYYSYLHTRYQQGTLGKDSIGLMQIAQNNSGRIVENQQHHAPIVVGLSLSKKL
                     NERWSLETGLQYTLLRSEFTTGEAFRIQDNQKLHYIGIPLRLSYRFWHYKRFSSYATAG
                     MQVDIPIKGTLQSFHVTDSIPHKLDSQPVSAPWQWSVNTSIGIQYHLTPQAGIYLEPTV
                     NYYIPDGSQLRTIRKEHPFTFTLPVGLRISW"
     CDS             1022..1819
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089:methyltransferase (Score: 55.3; E-value:
                     1.1e-16)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg36_2"
                     /transl_table=11
                     /translation="MQKRHTDRESYFDEQSQTSKNYYIPYIKEVIGHIPDKVLEVGCGE
                     GGNLLPFAKAGCRVMGVDIDAMRIEQARTFFTQRHQQGQFIATDIFQLKDKATNFPLIL
                     LHDVIEHIRDKERFLSGLQKHLSADGAVFVGFPAWQMPFGGHQQIAHSHIVSHFPFLHL
                     LPRTLYRWILRLCGEQERVITELLDIKSTGCTIELFNRIVRQANYQIIDRRLYLINPHY
                     KIKFGLSPRRLNGVIAAIPYIRNFFCTSCFYILKKGTKTVNHY"
     CDS             complement(2019..2504)
                     /locus_tag="ctg36_3"
                     /transl_table=11
                     /translation="MKIHEGKCTEKILKERERIGSRLAILRKKRNMTQEELANLCGVNR
                     VNIAKIEKGAYNVSIDILSKVTSALGFVIDIKVDSSVCPTHFSQRKPVKLVIGKDYYVS
                     FGNNEAHRCKLVDIPEMYQGQRIKIETPTPRGSITHILFADEIGTTPDEAVMNQVTM"
     CDS             3929..6757
                     /locus_tag="ctg36_4"
                     /transl_table=11
                     /translation="MKNLIALTLLLGGSTLLCAQKPAKTPATYKPVKSEMYRKGWIDFN
                     KNGVKDVYEDPSAPLEARIENLLQQMTLDEKTCQIVTLYGYKRVLKDDLPTPEWKELLW
                     KDGIGAIDEHLNGFQQWGLPPSDNAYVWPASRHAWALNEVQRFFVEDTRLGIPVDFTNE
                     GIRGVESYRATNFPTQLGLGHTWNRELIRQVGLITGREARMLGYTNVYAPILDVGRDQR
                     WGRYEEVYGESPYLVAELGIEMVRGLQHNHQVAATGKHFAAYSNNKGAREGMARVDPQM
                     SPREVENIHIYPFKRVIREAGMLGVMSSYNDYDGIPVQGSYYWLTTRLRGEMGFRGYVV
                     SDSDAVEYLYTKHGTAKDMKEAVRQSVEAGLNVRCTFRSPDSFVLPLRELVKEGGLSEE
                     VINDRVRDILRVKFLIGLFDAPYQTDLADADREVEKEENEAIALQASRESIVLLKNAGE
                     LLPLDINSTKKIAVCGPNANEEGYALTHYGPLAVEVTTVLEGIQEKTKGKAEVLYTKGC
                     DLVDAHWPESEIIDYPLTDDEQAEIDKAVENARQADVAVVVLGGGQRTCGENKSRTSLD
                     LPGRQLQLLQAIQATGKPVVLILINGRPLSINWADKFVPAILEAWYPGSKGGTALADIL
                     FGDYNPGGKLTVTFPKTVGQIPFNFPCKPSSQIDGGKNPGPTGNMSRINGALYPFGYGL
                     SYTTFEYSDLDITPRVITPNESATVRLKVTNTGKRAGDEVVQLYIRDVLSSITTYEKNL
                     AGFQRIHLEPGEAQELSFTIDRKHLELLDADMKWVVEPGDFVLMAGASSEDIRLNGTLT
                     VEDYQTRAKAIEAQKPAKRVSASTNPEDAENVLDEKINTAWQGNKGDYITFALKNGAKV
                     DKVAIAFTRDNNLPATFEIQLSGGGGQFLTVYSGTVSEYGKLISYPFKGTTASDLRIVL
                     NDDRVSIAEVKF"
     CDS             6859..7986
                     /locus_tag="ctg36_5"
                     /transl_table=11
                     /translation="MKTLLFCMLGLGLTACGSSPKGTNGDQDELAMLIGTYTNGSSKGI
                     YTFRFNQETGTAVPLSSAALPNPSYLVPSEDGEFVYAVSEMNDSTAALSSLAFDRETGE
                     LRLLNTVPTFGADPCYVATNGREVLTANYSGGTMSVFPLQKDGTLAPADTLFQGSATGP
                     DAIRQATPHIHCTVFSPDGKYIFATDFSADRILRFVMHPDDPIPHASLEAVDIEADSGP
                     RHLTFSPNGKFAYLITELSGKVIAFSYDDGCLEQIQTITADTVAARGSADIHLSPDGKY
                     LYASNRLKEDGIAIFAVNPENGTLAKVGYQPTGIHPRNFNITPNGKYLLAACRDSNVIQ
                     VYKRNEVTGLLEDTHQDIVVDMPVCVQFVSSVNNL"
     CDS             8057..9106
                     /locus_tag="ctg36_6"
                     /transl_table=11
                     /translation="MKKNILMLSALFLSITAMAQTDVTTGVMRGKDYGVTYMLPKTEIE
                     IVLQATKHTYTPGEFCRYADRYLRLNNVSAEPEEFWTLDKIETRIAGVPDKDNVYFVKM
                     KDKTVAPLMELTEDGIVRSINIPFSGKPAAKTPEAKATESSIDPRSFLTEEILMSNSSA
                     KMAELVAKEIYSIRESKNALLRGEADNMPKDGAQLKLMLDNLNQQETAMTEMFSGKIKK
                     EPKTFTIRLTPKEMKDEVAFRFSRKLGVVANNDLAGEPYYISVTDLKSPDVSATEEGKK
                     KVDGVAYNLPGKAQVTLMYNNKKLFDDQLPITQFGTVEYLAPVLFNKNSTIKVLFDTAT
                     GGLIKVDRE"
     CDS             complement(9114..9467)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg36_7"
                     /sec_met_domain="PqqD_RRE (E-value: 1.1e-10, bitscore:
                     30.9, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 1.9e-17, bitscore: 53.1,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMEIPEGKVSLLDAVPVRCGHITTEWEGECAVLAYPRFKYEWMRR
                     FLLPKGMSPDIHVRLEEHGTAVWNLIDGHRTVREIISLLARHFGEEENYIPRVTAYVMQ
                     LRKDGFIQLTIRN"
     CDS             complement(9487..10878)
                     /gene_functions="transport (smcogs) SMCOG1106:major
                     facilitator transporter (Score: 102; E-value: 4.6e-31)"
                     /gene_kind="transport"
                     /locus_tag="ctg36_8"
                     /transl_table=11
                     /translation="MTEQLKLKLNDSKATRWGALVIVAFTMMVAYYVNDVVAPLKTMLE
                     TDLAWSSTDFGFFTGGYSFLNVFFLMLIWGGLILDRFGIRFTGKLATILMVGGTALEYY
                     AMTGLAGADATLFGINEIFGYKTGVFVAFAGYSIFGVGAEVAGITVSKIIAKWFKGKEL
                     ATAMGVQVALARIGSQAGYAVAIPLARAFGISTPVLLGLVLLLGGMIAFFIFAVMDKKL
                     DKQMEAAAIAAGTEDEEEKFSFKDVKNILVNPGFWLIALLCVLFYSCVFPFQKFASELM
                     IIKYGINENVAGTFAGLPALGALILTPVFGGFIDKRGKSASIMLLGSAMLICVHFIYAI
                     PDINYWLVAIVLMIILGIAFSLVPSAMWPAVAKIFPVSQLGTAYALIFFIQNIGLWGIP
                     TLIGWVLDAYCISGKKPDGTNMYDYTVPMCIFTGIACLSLIVALLLKKADKKYGYKLEE
                     PNIQK"
     CDS             complement(11032..11421)
                     /locus_tag="ctg36_9"
                     /transl_table=11
                     /translation="MYLLLVILMLIASVLMCFIVLIQNSKGGGLASGFSSSNQIMGVRK
                     TTDFLEKATWTLAAVMVVFSIVSAYTIPSSTGKGGDVILEQAQQEEKTNPYNMPVGTEA
                     PQSEAPAATTPAETPAPAAEAPAAE"
     CDS             complement(11426..12199)
                     /locus_tag="ctg36_10"
                     /transl_table=11
                     /translation="MTPTHLQQWIQHPETLNRDTLYELRTLVARYPYFQSLRLLYLKNL
                     YLLHDINFGAELRKAVLYVADRRVLFYFIEGDRYTLKSRKVSSLFSGDLEKEPSVDRTL
                     SLIDAFLATVPEEHSQHTELDYAVDYTAYLMQEEPGVDAEDESEVPKLRGHELIDDFIQ
                     KSESSDASDTRREFLVEKEEETEEEEEPSVSPVTEELDDSCFTETLAKIYIKQHRYDKA
                     LEIIKKLSLNYPKKNAYFADQIRFLEKLIINAKSK"
     CDS             complement(12204..12728)
                     /locus_tag="ctg36_11"
                     /transl_table=11
                     /translation="MDWIKKAAFASLLVSLLFLVNSCSMKLGLAPISSIDYTKVKTISI
                     ADFQNRAEYVYAPLATEFNQKMKDMFIQQTRLQLVNSGGDLEIDGEITGYNQYNESVDA
                     SGYSSKVKVTLTVNVRYTNNTNHEEDFEQQFSAFQTYDSSKLLTEVQDQLITLMVKDIA
                     EQIFNATVANW"
     CDS             complement(12715..13065)
                     /locus_tag="ctg36_12"
                     /transl_table=11
                     /translation="MLKKLVHEIMAERGTVANSAVATSAYYTPATPAVVPPVTSSVPTI
                     IHPSVKPVTPVDDDFQDTEEYVEESLSLDEVEKEMIRKALEKHHGKRKSAAQDLNISER
                     TLYRKIKEYGLD"
ORIGIN
        1 caaagaaaat ctgaacaaaa gggaacgaat catccctccc gttcctgttt ccacagaatg
       61 gccccttgcc atacccaaaa tgaaagatag catccacaaa tatcccatac cttctccatt
      121 caccggacag accatcacca accggcagat ggctttcgcc tcctcccctt ccctaatgcc
      181 gccaacccgc aagaagaaat ccaggaaatg gaagttgatg ctggcaggtt cactcggacc
      241 gcaactggca cagaacttat ataagctgat tgccactcca cataccgacg gcatttcaag
      301 tgacttccct caacaagtca gcacgtggga agagtattat tcttatctgc acacccgcta
      361 tcagcagggt actctgggaa aagattccat cggactcatg cagattgccc agaataacag
      421 cggcaggatt gttgagaacc agcaacatca tgcccccatc gtcgtgggac tctctctcag
      481 caagaaattg aatgagcgtt ggagtctgga aaccggattg caatatacgc ttctcaggtc
      541 ggagttcact accggcgaag cattccgcat tcaagacaac cagaagttgc attatatcgg
      601 cattcctctc cggctttcct accgtttctg gcattacaaa cgtttctcca gttatgccac
      661 ggcaggcatg caggtggata tccccataaa agggacactc caaagcttcc atgtcacaga
      721 cagtattcca cacaagctcg acagccagcc ggtaagtgct ccctggcagt ggtcggtcaa
      781 cacaagtata ggcatacaat atcacctcac accccaggca ggcatctatc tggagccgac
      841 tgtaaactat tatatccccg acggcagcca actgcgcacc atccgaaagg aacacccgtt
      901 cacattcacc ctcccggtag gcctccgcat ttcctggtaa aaaaacgatg cgccacgcag
      961 tcttttaccc gactgattat ctatttatat ggataatcaa actcaagaag gaacaaagaa
     1021 catgcagaaa cgacataccg accgggaaag ctactttgat gaacagtcac agaccagcaa
     1081 gaactattat atcccctaca taaaggaagt catcggacac atccccgata aagtgctgga
     1141 agtgggctgt ggagagggag gcaatctgct tccctttgcc aaagccggtt gccgggtgat
     1201 gggcgtagac attgatgcca tgcgaataga gcaagccagg accttcttca cccaaaggca
     1261 tcagcaggga cagttcattg ccaccgacat tttccagctt aaggacaagg ctacgaattt
     1321 tcccctgatt cttctacacg atgtgataga gcatatcaga gacaaagaac ggttcctctc
     1381 cggcctacaa aaacatttgt ctgccgacgg agctgtattt gtagggtttc ccgcctggca
     1441 aatgccattc ggaggccacc agcagatagc acacagccac attgtttcac atttcccttt
     1501 tctccacctc cttccccgca ctttatacag atggatatta agactatgcg gtgagcagga
     1561 acgcgtaatc acggagctac tggatataaa gagcaccgga tgcaccatcg aactgttcaa
     1621 tcgcatcgtc cggcaagcca actatcaaat cattgaccgg agactgtacc ttataaaccc
     1681 acattataaa atcaaattcg gcttgtcccc acgaaggctc aacggagtta ttgctgctat
     1741 cccgtatata agaaacttct tttgtacaag ttgcttttac atattaaaga aagggactaa
     1801 aactgttaat cactactgat ttcccagctt tagaattgat tccgaaccat caatttaaga
     1861 ttatatattc agaagaaacc attaattttt tgaatagctc tgatgaaaga gtgggtgtag
     1921 aaaccctcat aaactaaaaa atccccctcg ctgcagatgg ttgtagcgaa ggtgatttca
     1981 ataaaagagg aacttgcact tcctcccttt taatgttttt acatcgttac ttggttcatt
     2041 acagcctcgt caggtgtcgt tcctatttca tcggcaaata atatgtgggt gatagaccct
     2101 ctcggggtcg gagtttcgat tttaattctt tgaccttggt acatctccgg aatatcaacc
     2161 agcttacatc tatgggcttc gttattgcca aaactgacat aatagtcttt ccctattacc
     2221 agctttacag gtttacgttg agagaaatga gtcggacaaa cagagctatc cacttttata
     2281 tctatcacaa aaccaagagc ggatgttacc ttagatagta tatcaatgct cacattataa
     2341 gcccctttct ctatcttggc tatattaaca cgattaacac cacaaagatt agccaattcc
     2401 tcttgggtca tatttctctt cttgcgaaga atggctaacc gactaccaat ccgttcacgt
     2461 tctttcaaaa tcttctctgt acattttcct tcgtgaattt tcataaatct gttgcagaat
     2521 ttaaagtgtt gcccccactt ctaatagtta ttgatttttg aacagacaaa agtagatatt
     2581 aattttgaat tgtagcacat ttactacaac tattttctaa atgaatataa aaggtagggg
     2641 gagtagaaga aaagaaaaag cccctgaatt actggaattc aaggacttac aaacttcttt
     2701 ttactatatc cgtggagctg gagggaatcg aaccctcgtc caaacgagga aatcataagc
     2761 tttctacatg cttatctttg cctaaatttt cgtgcagcgg cagaaccaaa gccatcaacc
     2821 gttgccttat cctctaaatt ttcacccgcg ccacgaggct gacacgaact atccccgatt
     2881 tgactgcacc actttatcgg aatgcttcgg agcaacagct tccgagtgat gtcacgtccc
     2941 agcacctggt gccgggatta agcttcaatc tactatactt cgattaagca gcgagagcgt
     3001 aacgagtttc gccagataaa attttgagga ctgagattaa agtgcaaatc aacgacgcac
     3061 tgcatgctta cttaccattt ctgcccgctg tcaaatccag tcaaccccat gactttgtaa
     3121 cggtctgaaa tttaaaagat tgcgtaactc attgctaagt agggagggtg aaaaagggat
     3181 aaatgctact ttatttttca tcctctaccg ctttctttgg cccaaagata catattcttt
     3241 tattagcaat caccatatat ttacaaatat tagctaatac tgacttttcg tgataaaaac
     3301 aataatcttc catacataga atatgtgcac cccattgtca tcaatgttca aacagctacc
     3361 aaagccagta tccgttgacg gaattacccc ctgcaagagg gaatatctat cttctgtaat
     3421 ggatatttgc acaaaagaga tgggaaatta acggaaaaag tctctgaagt taactgaaaa
     3481 accggaaaga attaaggaag caatctatcc caaactttgg ttttttcata cccagccttg
     3541 ggatgtctaa accaaggttt ggtttagaca tcccaaggtt gaaaagaaag ttcttccgta
     3601 caagcaacaa ttccgccaac agattcctat tatataaata caccctcgtt taacagatgt
     3661 agccgtaata cttgtataca ccgcgattgc atctactttt caggttatta tagtgttctc
     3721 tctttctttt taaaagtgaa tgatatgttt cgtctaataa tgatttgaat tccccggtag
     3781 cgtcttggag gatattttta gtaagaggaa gacccttcgg acaataaaag ccgatacttc
     3841 ggactatttt atccctttat ttcacacatt agccgtattt ttgtcaacaa aagaaacaat
     3901 aataaccaag agatttttag aacatatcat gaagaacctt attgccctaa ccctgctgct
     3961 tggaggaagc acactgctct gcgcacaaaa gcctgccaaa acaccggcaa cctacaagcc
     4021 ggtgaaaagt gaaatgtacc gcaaaggttg gatagacttc aacaaaaacg gagtgaaaga
     4081 cgtgtacgaa gacccctccg ccccgctcga agcacgcatc gaaaacctgc tgcaacagat
     4141 gacgctggac gaaaagacct gccaaattgt caccctctac ggttacaaac gtgtactgaa
     4201 agacgacctc cccacccccg aatggaaaga gctgctctgg aaagacggta tcggcgccat
     4261 cgacgaacac ctaaacggct tccagcaatg ggggctgcct ccctcggaca atgcctacgt
     4321 ctggcccgcc tcgcgccacg cctgggcact gaacgaggtg caacggttct ttgtggaaga
     4381 tacccgtctc ggtatccccg tagactttac caacgaaggc atacgcggcg tggaaagcta
     4441 ccgcgccacc aacttcccca cccaactggg actgggacat acctggaacc gtgaactgat
     4501 tcgccaagta ggactcatca ccggacgcga agcccgcatg ctgggctaca ccaacgtcta
     4561 cgcccccatc ctcgacgtag gacgcgacca gcgctgggga cgctacgaag aagtttacgg
     4621 cgaatctccc tacctcgtag ccgaactggg catcgaaatg gtgcgcggct tgcagcacaa
     4681 ccaccaagtg gccgccaccg gcaagcactt tgccgcttac agtaacaaca aaggcgcccg
     4741 cgaaggcatg gcacgcgtgg acccgcaaat gtcgccgcgc gaagtggaaa acatacacat
     4801 ctaccccttc aaacgcgtca tccgggaagc tggcatgctg ggcgtaatga gttcgtacaa
     4861 cgattacgac ggcatccccg tgcagggcag ctactactgg ctcaccaccc gcctgcgtgg
     4921 cgaaatggga ttccgtggct acgtcgtatc cgacagtgac gccgtagaat acctctacac
     4981 caagcacggc accgccaaag acatgaaaga agccgtccgc caaagcgtgg aagccggact
     5041 gaacgtacgc tgcaccttcc gctcgcccga ctccttcgtc cttcccctcc gcgaactggt
     5101 gaaggaaggc ggactgagcg aagaagtcat caacgaccgc gtgcgcgaca tccttcgggt
     5161 aaagttcctc atcggtctgt tcgatgcccc ctatcagaca gaccttgccg atgccgaccg
     5221 tgaagtggaa aaagaagaga acgaagccat tgccttgcag gcatcccgcg agtccatcgt
     5281 tctgctgaag aatgccggtg aactattgcc cttagacatc aactccacca agaagattgc
     5341 cgtctgtggt cccaatgcca atgaagaagg ctacgcgctg acccattacg gcccacttgc
     5401 cgtagaagtg accactgtgc tggaaggcat tcaagaaaag acaaaaggca aggcagaggt
     5461 gctctacacc aaaggctgcg acctggtgga cgcccactgg cccgaaagtg aaatcataga
     5521 ctatccgctg accgacgacg aacaagccga gatagacaaa gccgtagaaa atgcccgtca
     5581 agctgatgtt gccgtcgtag tattgggcgg cggacaacgc acctgcggcg aaaacaaatc
     5641 gcgcaccagc ctcgacctgc ccggtcggca gttgcaactg cttcaagcca tacaagccac
     5701 gggcaagccc gtcgtactga tactcatcaa cggacgcccg ctctccatca actgggcaga
     5761 caagttcgtc cccgctatcc tcgaagcctg gtatcccggc tccaaaggcg gaacagccct
     5821 ggccgacatc ctcttcggcg actacaaccc cggtggaaag ctgacggtga ccttccccaa
     5881 gaccgtaggg caaatcccct tcaacttccc ctgcaaacct tcttcacaga tagacggcgg
     5941 taagaatccg ggacctacgg gcaacatgtc acgcatcaac ggagcactct accccttcgg
     6001 ttacggcttg agctacacca ccttcgagta ctccgacctc gacatcaccc cccgagtcat
     6061 caccccgaac gagtctgcca ccgtccgcct gaaggtgacc aacaccggca aacgtgccgg
     6121 agatgaagta gtgcagctct atatccgcga cgtactgagc agcatcacca cctacgaaaa
     6181 gaatcttgca ggcttccagc gcatccacct cgaaccgggc gaagcccagg agctgtcctt
     6241 caccatcgac cgcaagcacc tggagcttct ggacgctgac atgaaatggg tggtggaacc
     6301 cggcgacttc gtgctcatgg ccggcgcctc ttccgaagac atccgcctga acggaacgct
     6361 gaccgtagaa gactaccaga cccgtgccaa agccattgaa gcccaaaaac cagcaaagcg
     6421 tgtgagtgcc agcaccaacc cagaggatgc cgaaaacgtg ctcgacgaaa aaatcaatac
     6481 cgcatggcaa ggaaataagg gagattatat tacctttgcc ttaaagaacg gagccaaggt
     6541 agataaagtt gccattgcct ttacacgtga caacaacctg ccggcaacct tcgaaatcca
     6601 gctctcgggc ggtggcggac agttcctcac cgtatattcg ggcaccgtca gcgaatacgg
     6661 caaactgatt tcctatccgt tcaaaggcac taccgccagc gacctccgca tcgtgctgaa
     6721 cgatgaccgc gtcagtattg ccgaagttaa attttaatgt gctaatgtgc caatatgcta
     6781 atgtaccaat gaccatgcag catatacagc gcagccaatt agcacattag catattggca
     6841 cattaacaca ttaaattaat gaaaacactt cttttctgta tgctcggatt aggtttgaca
     6901 gcatgtggct cttctccaaa gggcactaac ggtgaccagg acgaactcgc catgctaata
     6961 ggtacttaca cgaatggctc aagcaagggt atctatacct tccgctttaa tcaggagacg
     7021 ggaacagccg ttccgctcag ttcagcggca ttgcccaatc cctcctacct cgtcccctcg
     7081 gaagatggcg aatttgtcta tgccgtcagt gaaatgaacg acagcacagc agccctcagc
     7141 tcccttgcct tcgaccggga aacgggagaa ctgcgcctgc tgaacaccgt tcccaccttc
     7201 ggcgccgacc cctgctacgt ggccaccaat ggccgggaag tgttgactgc caactacagc
     7261 ggtggaacca tgtccgtctt tcctttacag aaagacggca ctttggctcc tgcagacacg
     7321 ctctttcaag gctctgccac cggtcccgac gccatacggc aagccactcc ccacatccat
     7381 tgcacggtct tttcaccgga cggaaaatac atctttgcca ccgacttcag tgccgaccgc
     7441 atcctgcgct ttgtgatgca ccccgacgac cctattcctc atgcttctct ggaagccgtt
     7501 gacattgaag cggattccgg cccgcgccat ctgacattca gccctaacgg gaagtttgcc
     7561 tatctcatca ccgaactgtc cggtaaggtc attgccttca gttacgacga cggctgcctg
     7621 gaacagatac agactatcac agccgacacc gtagccgccc gtggaagtgc agacatccac
     7681 ctcagtccgg atgggaaata cctctacgcc agcaaccgtc tgaaagaaga cggcatcgcc
     7741 atctttgccg tgaatcccga aaatgggacc ttggcaaagg taggttatca gcccaccggc
     7801 atccatcccc gcaacttcaa catcacgccc aacggcaaat acttgcttgc cgcctgccgc
     7861 gacagcaatg tcattcaggt atacaaacga aacgaagtta ccggactctt ggaagatact
     7921 catcaggaca ttgtagtcga catgccggtt tgcgtacagt tcgtcagctc tgttaataat
     7981 ttataaagca atatttagca aagataactt cattaacttt gtcccttagc taaatcagtc
     8041 taaacgaatg tacattatga agaagaatat attgatgctc tcagctctgt tcttgtctat
     8101 cactgccatg gcgcaaacag acgtaaccac cggtgtgatg cgtggcaaag actacggagt
     8161 gacttatatg ttgcccaaaa cagaaataga aatcgtattg caagccacca agcataccta
     8221 cactcccgga gaattttgca gatatgccga ccgctatctg cgtctcaaca acgtgtctgc
     8281 cgaacccgag gagttctgga cactggataa gatagaaacc cgcatagccg gtgtaccgga
     8341 taaggacaac gtctatttcg tgaagatgaa agacaagacc gtagcacccc ttatggagct
     8401 taccgaagac ggaattgtcc gctccatcaa cattccgttc agcggtaagc ctgctgccaa
     8461 gacgcccgaa gccaaagcca ccgaaagcag cattgaccca cgcagttttc tgacggaaga
     8521 aatactgatg tccaactcca gtgccaagat ggccgagctg gtggccaagg aaatatacag
     8581 catccgcgaa agcaagaatg ccctcctgcg cggcgaagca gacaatatgc ccaaggacgg
     8641 cgcccaactc aagctgatgc ttgacaatct gaaccagcag gaaacggcta tgacggaaat
     8701 gttctcgggc aaaataaaga aagaacccaa gacattcacc atccggctga cgcctaaaga
     8761 gatgaaagat gaggtggctt tccgtttttc ccggaagctg ggagtggtgg ccaataatga
     8821 ccttgccggt gaaccgtatt atatcagcgt caccgacctc aaaagtcccg atgtatctgc
     8881 caccgaggaa ggcaaaaaga aagtggacgg tgtagcctat aaccttccgg gcaaggcaca
     8941 agtgacattg atgtataaca ataagaaatt gtttgacgac caacttccca ttacccaatt
     9001 cggcaccgta gaatacctcg caccggtact gttcaacaag aattctacca tcaaagtgct
     9061 gtttgatacg gcaacgggag gattgataaa agtagatagg gaataaagga attctaattc
     9121 cggattgtca actggataaa tccatcctta cgcaactgca ttacgtaggc ggtgacccgg
     9181 ggaatataat tctcttcctc cccaaagtgc ctggcaagta gagagatgat ttcgcgcacg
     9241 gtacgatgtc catctatcag attccagaca gctgtaccgt gttcttccag cctcacatgg
     9301 atgtcaggag acatcccctt cggcaataaa aaacgacgca tccattcgta tttaaaccgt
     9361 gggtaggcga gtacggcgca ctcaccttcc cattcggttg ttatatgtcc acagcggacc
     9421 ggaacagcgt ccaacagact tacttttcct tcgggtattt ccatcatacg gtatccgctt
     9481 ttcctattat ttctgaatat taggctcttc cagcttataa ccatacttct tgtctgcctt
     9541 cttcagcagt agagccacta taagggacaa gcaggcaata ccggtaaaaa tgcacatagg
     9601 caccgtatag tcatacatat tcgttccatc tggtttcttg ccggatatac aataggcatc
     9661 aagcacccac cctatcaatg taggaatacc ccaaagaccg atattctgga taaagaaaat
     9721 caatgcgtat gccgtaccca actggcttac cgggaatatc ttggccacag ccggccacat
     9781 ggcagaaggt accagcgaga aagcgatacc caaaattatc atcagcacaa tagctaccag
     9841 ccaatagttt atatcgggaa tagcataaat gaaatgcaca catatcagca tggccgagcc
     9901 cagcagcatg atagatgcgg acttgccccg cttgtcaatg aaaccaccaa agaccggagt
     9961 cagaatcagc gctcccaatg ccggaagtcc ggcaaatgta ccggccacat tctcattgat
    10021 accgtatttg ataatcatca actcggaagc aaacttctgg aatgggaata cacaagagta
    10081 gaacaataca cacagcaatg ctatcagcca gaaaccggga ttgaccagaa tattcttcac
    10141 atccttaaaa gagaacttct cttcctcatc ttccgtaccg gcagcaatgg cagcagcttc
    10201 catctgtttg tccagcttct tgtccatcac tgcaaagatg aagaaagcaa tcataccgcc
    10261 caacaacaga accaaaccca acaacaccgg tgtggaaata ccgaaagcgc gggccaaagg
    10321 aatggctacg gcataaccgg cttgcgaacc gatacgtgct aaagcgactt gtacccccat
    10381 agccgtggca agctctttcc ccttaaacca cttggctatg attttggaaa ctgtaatacc
    10441 ggcgacctcc gctcctactc caaaaatgga ataaccggca aaagcaacaa acacacccgt
    10501 tttatagcca aatatttcat tgattccgaa taaagtcgcg tcggcaccgg caagtcccgt
    10561 cattgcatag tattcaagtg ctgtaccacc taccatcagg atagttgcca gctttccggt
    10621 gaaacggata ccaaagcggt cgaggattaa tcctccccaa atcaacatca ggaaaaaaac
    10681 attcagaaaa ctataaccac cggtaaagaa tccgaaatcg gtactcgacc aagccaagtc
    10741 cgtttccaac attgtcttca acggtgctac cacgtcgttt acataataag ctaccatcat
    10801 cgtgaaggca acaatcacca atgcccccca acgggtagcc ttggaatcat tcaatttaag
    10861 tttgagttgt tctgtcattg tactatttgg atttcaattt attaatcaga ttgcataaat
    10921 tgctgacaaa ggtaaataaa tacttcatca aaacgaaaaa aggctgacac cttttcagta
    10981 tcaacctttc tcttattttt ccaagcggga gtcatccgca atatccttat cttattctgc
    11041 tgcaggggct tctgctgcag gagcaggagt ttcagccgga gttgtagctg caggggcctc
    11101 cgattgcgga gcttctgtac ctacgggcat gttataagga ttagtttttt cttcttgttg
    11161 cgcctgttcc agaatcacat caccgccctt gcctgtggaa gaaggaatag tgtaagcaga
    11221 aacaatactg aagactacca tgacagctgc cagagtccag gttgcttttt ccaaaaagtc
    11281 cgtagtcttg cgcacaccca taatttggtt ggatgatgaa aagcctgatg ccagaccacc
    11341 tcctttagaa ttttgaatca atacaatgaa gcacatcagc acagatgcaa tcagcattaa
    11401 gataactaat aataaataca ttttgttatt ttgatttagc gttaataatc aatttctcca
    11461 aaaatctgat ttggtctgca aagtaagcat ttttttttgg ataattcaaa cttaattttt
    11521 taataatttc aagcgccttg tcatatcggt gctgttttat atagattttg gctaaagttt
    11581 ccgtaaaaca gctatcgtcc aactcttccg ttaccggcga tactgagggt tcttcctctt
    11641 cttcagtctc ttcctccttc tctacaagaa actcccttct cgtatccgag gcatccgaag
    11701 actcactctt ttggataaag tcatctatca attcatgccc gcgcagttta ggcacttccg
    11761 actcatcttc tgcatccaca ccgggttctt cctgcattaa ataggccgta taatccaccg
    11821 cataatccag ctccgtatgc tgtgaatgct cttcgggaac agtagccaga aatgcgtcaa
    11881 tcaaggaaag ggtacggtcc acactcggct ctttctccaa atcgccggaa aacagcgacg
    11941 agaccttccg ggatttcaaa gtatagcggt caccctctat aaagtaaaac agcacacgac
    12001 ggtctgccac atacaacaca gccttgcgca actccgcgcc aaagttgatg tcgtgcagca
    12061 gatagaggtt tttcagatag agcaaacgga gcgactggaa ataaggatag cgtgccacca
    12121 atgtgcgaag ctcgtacaaa gtatccctat tcagcgtctc gggatgctga atccattgtt
    12181 gcaaatgggt aggcgtcatg agtttaccag ttagctacag ttgcattgaa aatctgttcg
    12241 gcaatgtctt tcaccatcaa ggttatcagc tggtcctgca cttcggtcag caattttgag
    12301 gaatcatagg tctggaaagc cgagaactgc tgttcaaagt cctcctcatg gttcgtgtta
    12361 ttggtgtagc gcacgttgac agtcagcgtc accttcacct tcgaagagta gccgctggca
    12421 tccaccgatt cattatattg attgtagccg gttatttctc cgtctatttc caggtctcct
    12481 ccggaattca ccagttgcag gcgagtctgc tgaatgaaca tatccttcat tttctggtta
    12541 aattctgttg ccagcggtgc atatacatac tctgcccggt tctggaaatc ggcaatggaa
    12601 atcgttttta cctttgtata gtcgatagag cttatcggag caagtcccaa cttcatacta
    12661 catgaattca ccagaaataa caagcttacc aacaaggaag caaatgccgc ttttttaatc
    12721 caatccatat tcttttatct ttctgtataa cgtacgctca gagatattca aatcctgagc
    12781 cgcactctta cgcttgccgt gatgtttttc aagcgcctta cgtatcattt ctttctccac
    12841 ttcatccagg gagagtgact cctccacata ttcttccgta tcctggaaat catcgtccac
    12901 cggagtaacc ggctttaccg aaggatgtat aatggtgggg acactggatg ttaccggagg
    12961 taccaccgcc ggagtagccg gcgtatagta ggccgatgtg gcaaccgccg aattggctac
    13021 cgttcccctt tcagccataa tctcatgcac caactttttc aagtc
//
