LOCUS       gnlProkkaADLKOMBC_17   12580 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|ADLKOMBC_17.
ACCESSION   gnlProkkaADLKOMBC_17
VERSION     gnlProkkaADLKOMBC_17
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-12-01 21:04:10
            Original ID  :: gnl|Prokka|ADLKOMBC_17
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 12580
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..786
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR04085"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) SPASM"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg17_1"
                     /sec_met_domain="TIGR04085 (E-value: 4.9e-11, bitscore:
                     35.0, seeds: 281, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 1.3e-07, bitscore: 24.2,
                     seeds: 166, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEKEIQGLNRLSKDKKNSFDIVYNNIRKIQLNNTRYFEQYVTINS
                     VYSINITSSLSEFTNYLEAHFKNKFAINIQSSEINDEYTKFHNNFTKSFLSIYENIHIQ
                     GFENSSPPLFIISSDLHKKMMFFSRRSNNILQEETRFIPIKSCLPYLNKIYISPTGDIF
                     MCSDLYYIKGFNIGNIDKSIELNKLQDIMTQYTNFRNKTCKKCWVYRFCDFCFYTLYAS
                     KERKGINKYCKIIKYDYAQVIKSYIKILKSNGSAFDIYY"
     protocluster    1..12580
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[1023:2580]"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      1024..2580
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
     cand_cluster    1..12580
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /kind="single"
                     /product="ranthipeptide"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..12580
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="ranthipeptide"
                     /region_number="1"
                     /rules="(TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085
                     or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /tool="antismash"
     CDS             1024..2580
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: Ranthipeptide_rSAM_RRE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: PF04055"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: TIGR04085"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg17_2"
                     /sec_met_domain="Ranthipeptide_rSAM_RRE (E-value: 4.9e-08,
                     bitscore: 25.2, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 1.6e-15, bitscore: 49.9,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 9.5e-10, bitscore: 31.0,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 7.8e-09, bitscore:
                     27.9, seeds: 281, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEKLEYKNSPVLGFILNSKYYLYDRYSNSIFTVPRIFFEYLDDLI
                     SLDTDEFTQKYHNIFSKEEIIDLFKTLDYCQNDKKLIKPNRIPKFTISSIYSNAKKVEK
                     KLKKELTFLCINITEECNLRCEYCIFSGKYTKSRRHNSNNQIEWNYIEKGVNLFLEHST
                     DSNIRKIGFYGGEPLLYFDIIRKTINYVRSKCDNAIFTITTNATLLKDKILSFFVENNV
                     EITISLDGPQNIHDKNRIFPNGVGSFNTVIKNIESIKRLHHDFFENNIKFSATLSPGKY
                     KIKDLIDFFTYDMFPTLKRADLPLSLNYINYEENKYLSEVKYLDWTKKTENEIFKLYKK
                     IHIKGINKTSEIPAVLRALPIHREMMYINLRSNIAFDEFKFFWPNGACIPGMRSIFLNS
                     KGIFLPCEKLNSETEFCIGDVSTGFDIKKISQLIADYSREIAPLCSNCWAFRFCGECWT
                     TAVKNGQISKDFRSQYCSYIKSYWARRLFLYTEIIEKNPKAFSYQGSIDYPEFMSHMIN
                     E"
     CDS             2593..3720
                     /locus_tag="ctg17_3"
                     /transl_table=11
                     /translation="MNKYITYLFLLLLSCGKPQDNNGIFTMDLSKDDLPKTTVSLDDYT
                     TKWTRIDLETTEDCLLDPSFNIYPTDHFIVAYSFNRILVFDHTGHFIREISHFGEGPDE
                     HGLLFNCTVNPTSEQLVFVEMGNTEEIIRYDLSSGKQLTAIPIVAKKQLCDLLFIKDST
                     LVCFPYAGNQKQMAYKQNLAGEWIGTPPIPISEPAGPYNPIPISLFQVDNQWIYKGIYE
                     DTLYLVNNLEPFARFSRKDISPSKTELEVQNSSFINHLFTSNGMSLFGYPQYQLKEVSE
                     GIFDLVLVDFRAFLFNHADKQILEIEKMNCPPLSIIYEQKNLNDLFMLISSRNPKKLVL
                     KVPAEFMGKEEDENPVLFISDLIYPKKKQPTRGKP"
     CDS             complement(3883..6387)
                     /locus_tag="ctg17_4"
                     /transl_table=11
                     /translation="MRSIMSKWGKHIAAIAVFLVLTVIYFSPAVFEGKVVRQGDTEKAI
                     GMGNSQMDEYEKTAQPGEFSAWSDAMFGGMPYVSGYGNPAPRFPGYLLVEKPLKALGYM
                     DAGMVFTGFVCFYILMCVMGVNWWLAIAGAIAFALASYNLIIIEAGHVTKAYVIAYMPL
                     TLAGMALLFKRKYLWGAVVFLLGVAFSIANTHLQITYYLLLLCFFVYLGYLFNKLKEKA
                     YKELGTVTAIMAGCVILAVLPNAQNMYAQWDLGQNSIRGATELTTTTPSGEKISSGLDK
                     DYAFAWSYGKGELLTLLVPNAYGGSSGGMLGPDSELYKELRAKGAQVGKEVQAPTYWGE
                     KTFTSGPVYFGALVCFLFVLGMFVIRNPMKWWLFGGSVFLILLALGRNFDSFNDFMFHY
                     LPMYNKFRTVEMALVIPGMVFPIIAIWGLKEVLSETVSDALLKKGLIAALAITGGISLI
                     LWLMPSMLLDFRSSFDAQYQLPDWYYNALLMDRASLASADALRSLVFILLGAALLFWFY
                     TSKDRKKVATFVGIGVAVLMLVDLWTVDKRYLNDSNFIRQKPTEVYKETVADQEIMKDK
                     DLSYRVLNLNNPFLETTTSYYHHSVGGYYAAKLRRYQELIDHRLQGELNSVIEAFQKAQ
                     IAEDLMGAFAACPSLNMLNTRYIIYNPEQPPLRNPFAFGNAWFVDKVEVVENADAEIAA
                     LNTINPLTTAVVDKRFADEVKGFTPQLDSTATITLDSYRPNKLVYTTKTNSEQLAVFSE
                     IYYQPGWEATIDGKPAPHFRADWILRAMLVPAGEHQIVFEFRPQGYITAAYITSFSSLI
                     ILLLLIGAIGYSIWRAKKDKTA"
     CDS             complement(6411..7172)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg17_5"
                     /sec_met_domain="Glycos_transf_2 (E-value: 3.1e-30,
                     bitscore: 97.3, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNQQPTFSIITITYNAERWLERTILSVLSQSYPNIEYILIDGASK
                     DKTVEIIKQYESGIASWISEPDKGLYDAMNKGLKRATGDYVWFLNAGDTLYTADTVQRI
                     VASLKKKVSLPDVIYGETQIVDAEGRSLGMRRLKAPEKLTWKSFRMGMLVCHQSFISKR
                     EIAPLYNTEYRLTADYDWCIQCLRRSKRIHNTRLTLSNFLEEGLSSVNRKASLKERYEV
                     MCKYYGKVSTILLHGWFAVRFYFAKWFKGRV"
     CDS             complement(7185..9047)
                     /locus_tag="ctg17_6"
                     /transl_table=11
                     /translation="MDDQHKPEWIKVDEWDFVEYVDSLLRSQEAVDLEFKTARAGFPNS
                     VWETYSSFANTDGGTIVLGIKEKNGALFVEGLLPEQIVSYRQIICNQLNNPDCVNVNLL
                     TDKNIQEVDYRGKSLLLIYVPRASRSQRPVYLTRNPLNGHTYKRNNEGDYKCTDTEVRR
                     MIADADEEHPRDSRILCNYSMEDIDLDSLKQYRLLLSSRQPDHPWLTLDDMAFLRKLGG
                     YRQDRQTGQEGFTLAGILMFGRTESITDNECAPSYFPDYQEKMSVDENVRWTDRICMDG
                     TWEANLFQFYRRVYPKLSSVLPKPFRLENGVRLEDTTTHVALREAFVNTLVHCDYMEEG
                     NITIEQWKDRYVFKNPGTLLVSKAQYYAGGESICRNKSLQKMFMLIGFSEKAGSGVNKI
                     FMGWKNANWRPPFVEEQSHPDRVVLNLPMESLYPEEVLEELKRLFGREIERIPYDQFTV
                     LALCYSEKQVSNERLQYILNQHSSNITKLLKSMCNAGFLESIGNGRGTRYRLLFLEKDE
                     SKPQKDESKLKKDESKSQKDESKLEKDESKKYMRYEDLSRLILSVCEDYVALEIIAEAV
                     HREASYLINRVIPRMLEDGLLERLYPSSPKHPLQKYRVRQVGNL"
     CDS             complement(9146..10408)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1045:glycosyl transferase group 1 (Score: 121.7;
                     E-value: 6.9e-37)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg17_7"
                     /sec_met_domain="Glycos_transf_1 (E-value: 1.1e-25,
                     bitscore: 82.2, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKILILNTSELTGGAAVAANRLAKALGKSGVEVSMLVRDRKTDHV
                     KVFSVNNSWTSHRLNSFRFIWERLIIFICNFFSKKNLFQVSIANTGTDLSKHPLVQQAD
                     VIHLHWVNQGFLSLSDIKKLVNTGKPIVWTMHDLWPATAICHYPGGCEKYISNCYQCPM
                     LKRNPFFDLAASVFKEKGKIGLSKITFVGCSRWIMEEAQKGNWLRTACFTSIPNPIDVT
                     AFKRMEKRVARKRFDLPEGKFLLLFAAAKLSDTRKGAIFLIEACEKLKEKYQDRIEIVL
                     MGNSSEELISQFPFKVNTLGYISDQDSMISVYACADMFVIPSLEDNLPNTIMESMACGT
                     PCVGFETGGIPEMIDHLKNGYVAKYKDTNDLAVGIKWIIDNQETFRFSEACVRKVHDCY
                     RESVIAEKYIALYQSLCNKRK"
     CDS             complement(10405..11736)
                     /locus_tag="ctg17_8"
                     /transl_table=11
                     /translation="MEENQHTEFKESWHDEYTRYISAFCNTEGGVLYIGIDDKGEVVGI
                     EQPKKLIEKLPNFIAQKTGIMPLIHLREKAGKEYLEIEVQPSAMPISVHGRYYTRSGSV
                     TSELQGNQLNMFLAAKMGLTWESVIEEDFSLEDIDTDTVERFKLLAKDRVPSIEQETDL
                     LALMERLNLIVGGRFKRAAVVLFGKNVQRYVLQARIKIGKFLTDTEVLTTDIVEGNLIQ
                     QVDRALDILRTKYLLSYISYEGIHRREKLVYPYEALREALLNSIIHREYFVSSEIQVRV
                     YEDKLVIGNEARLHDITVEDLSRPHPSRPHNKLIADVFYKAGFIESWGRGTQRIIDNCL
                     AEGLSAPVYEHKMGFLYLTFFHERINERINERINERINELSDMEREVYQILREEPTIRQ
                     IDLANRLDLTEQYIRKLIKKLKEHGWIERIGARKNGYWKIIEKS"
ORIGIN
        1 ggagaaaaag aaattcaagg attgaacaga ttatcaaaag ataaaaaaaa cagttttgat
       61 atagtatata acaatatacg caaaatacaa ctaaacaaca caagatactt cgaacaatat
      121 gtaacaataa attccgtata ttcaatcaat ataacaagtt ccctttccga attcaccaac
      181 tatctagaag cacatttcaa aaataaattt gctataaata ttcaatcatc tgagataaac
      241 gatgaataca cgaaattcca taataatttc acaaaatcct ttttatcaat atatgaaaat
      301 atacacatac aaggattcga aaatagctcc ccccctttat ttataatttc cagcgactta
      361 cataaaaaga tgatgttctt ttcaagaaga tcaaacaaca tcctgcaaga agaaacaaga
      421 tttattccca taaaaagctg ccttccttac ttaaacaaga tatatatatc accgacaggt
      481 gacattttca tgtgcagcga tttatattac ataaaaggat ttaatatcgg aaatattgat
      541 aaatctatag aattaaacaa gctacaagat ataatgacac aatacactaa cttcagaaat
      601 aaaacatgta aaaaatgttg ggtttataga ttctgcgatt tttgttttta tacattatat
      661 gcttctaaag aacgaaaagg aataaataaa tattgtaaaa taataaaata tgattacgcc
      721 caagtcatca aatcatatat taagatatta aaatcaaacg ggagtgcgtt tgatatatat
      781 tactaacata taaaattatt cagcgtatga aacaaaaaac gaagaaaatc tcatgggaaa
      841 actttaaaga cgagattaaa gtaatctctg ccggacagca aaagttactc accggaggtg
      901 gatgtgcttg ctgcatctgt agcccaggta atgggaatag cggtttagga ggctcaacca
      961 aagcttcaat ttcacattaa taacctgcgg ggagatttct ctccccgcat aagctttcac
     1021 tttatggaaa aactagaata caaaaatagc ccagtactag gtttcatttt aaattcaaaa
     1081 tattacctat acgatagata ttccaattcc atttttacag ttccaagaat attttttgag
     1141 tatttagacg atctaattag ccttgacaca gatgaattca ctcaaaaata tcataatatt
     1201 ttttcaaaag aggagattat agatctattt aagacattag attattgcca aaacgacaaa
     1261 aaactaataa aacctaatag aatacctaaa ttcaccattt catccatcta ttctaacgct
     1321 aaaaaagtag aaaagaaact caaaaaagaa ttaaccttcc tatgcataaa tataactgaa
     1381 gaatgtaatc tcagatgcga gtactgcata ttctctggga aatatacgaa atcaagaaga
     1441 cataacagca acaatcaaat cgagtggaat tatatagaaa aaggtgttaa tttattctta
     1501 gaacacagca cagactctaa tattagaaaa ataggtttct atggaggcga acctcttcta
     1561 tattttgaca taataagaaa aactatcaat tatgtccgaa gtaaatgtga taacgcaatt
     1621 ttcacaatta ccacaaatgc aactttacta aaagacaaaa ttttgtcttt ctttgtagaa
     1681 aataatgtag agatcaccat tagcctagat ggtcctcaaa acattcatga taaaaacagg
     1741 atttttccta atggcgttgg gagttttaac accgtcataa aaaacataga atctatcaaa
     1801 cgattacatc atgatttttt tgaaaataat ataaaattct cagcgacatt atcacctggg
     1861 aaatacaaaa tcaaagattt aattgacttt tttacatacg atatgttccc tacgctgaaa
     1921 agagcagacc ttccattaag tcttaattat ataaattacg aagaaaataa atatttaagc
     1981 gaagtaaaat atttagattg gacaaaaaaa actgaaaacg aaatttttaa gttatataaa
     2041 aaaatccata taaaaggaat caataaaact tctgaaatac cagcagttct aagagcccta
     2101 cctattcatc gagaaatgat gtatatcaat ttaagaagta atatagcttt tgatgaattt
     2161 aagttctttt ggcctaatgg agcctgcata cctgggatga gaagtatttt cttgaattct
     2221 aaagggatct ttttgccatg cgagaaacta aattcagaaa cagagttttg cataggtgat
     2281 gtatcaacag gatttgacat aaaaaaaata tcacaactca tagcagatta ctcaagagaa
     2341 atagctccac tatgttccaa ctgctgggca tttaggtttt gtggggaatg ctggacaacc
     2401 gcagtaaaga atggacaaat atcaaaagat tttagatcgc aatattgcag ttatataaaa
     2461 agttattggg caagaaggct atttttgtat acagaaataa tcgaaaaaaa tcccaaagca
     2521 ttctcttatc aaggaagtat agattatcct gaatttatgt ctcacatgat taacgaataa
     2581 actaaaacaa ccatgaacaa atacattaca tatctattcc ttttattatt atcttgcgga
     2641 aagccccaag ataataacgg tatattcaca atggatctat ccaaagatga ccttcccaaa
     2701 acaacggtat cattggatga ttatacaacc aaatggacaa ggatagatct tgagactact
     2761 gaagattgcc tacttgatcc atcgtttaac atctacccta cagatcattt tattgtcgct
     2821 tattccttta atcgaatcct cgtattcgac catacaggac attttatccg cgagatctcc
     2881 catttcggag aaggtcccga cgaacatggt cttttattca actgtacagt caatcctacg
     2941 agtgaacaac ttgtcttcgt agaaatggga aataccgaag aaataattcg ttatgatcta
     3001 tcgagtggca aacaattgac tgcgatacca atcgtcgcaa aaaagcagtt atgtgactta
     3061 ttatttatca aggactctac acttgtctgc ttcccatacg caggcaatca aaagcaaatg
     3121 gcctacaaac aaaatctagc cggggaatgg attggaacac cccccattcc catctccgaa
     3181 ccggcaggtc catataatcc catacctatc agtctatttc aagtggataa tcaatggatc
     3241 tataaaggga tctacgaaga cacgctttac ttagtgaata atttagaacc tttcgctcgt
     3301 ttttcaagga aagacatcag tccatcaaaa acagaattag aggtacagaa cagctctttt
     3361 ataaatcatc tgtttacctc taacggaatg tcattattcg gatacccgca atatcagtta
     3421 aaagaagtat ctgaaggcat attcgattta gttttagttg attttcgagc cttccttttt
     3481 aatcacgcag acaaacaaat tcttgaaata gaaaaaatga actgcccacc tctgtcaatt
     3541 atttatgaac aaaaaaattt aaatgatcta ttcatgctga tctcctcccg gaacccgaag
     3601 aaattggtac taaaagttcc agcggaattc atgggaaaag aagaagatga aaacccagtc
     3661 ttattcatat ccgacttgat atatccaaag aaaaagcagc ccactcgtgg gaaaccctaa
     3721 cgagaaaact gcttggcttt atccataacg aataatcgtt accaatttcc acctagttgt
     3781 agagacgggg cgtgccccgt ctcatctcct caaaatggaa actttaaaat acccattagt
     3841 ctgtgccgag acggggcacg ccccgtctct acaactggat atttaggctg tcttgtcttt
     3901 tttagctctc cagatcgagt aaccgatcgc tccaatcaat aacaaaagga ttatcaatga
     3961 actaaatgag gttatataag ccgccgtaat ataaccttgc ggtctaaact caaatacgat
     4021 ctgatgctct cccgcaggaa ctaacatagc ccttaatatc caatccgccc ggaaatgagg
     4081 agcgggcttc ccatcaatcg tagcctccca tcccggttga taatagatct cagagaatac
     4141 tgctaattgc tcagaattag tcttcgtcgt ataaactaac ttattagggc gataactatc
     4201 caatgttatc gtagcggtag agtccaattg aggcgtgaaa cctttcacct catcagcgaa
     4261 acgtttatcg acaaccgccg tcgttaacgg attaatcgta ttcaacgccg ctatttccgc
     4321 atccgcattc tccacgacct ccactttatc cacaaaccaa gcgttgccga aagcgaacgg
     4381 attcctcaaa ggcggttgct ccggattata gataatataa cgtgtattta gcatattcaa
     4441 ggacgggcaa gcagcgaacg cccccatcaa atcctccgcg atctgcgctt tctggaaagc
     4501 ctcgataacc gagttaagct ctccttgcag acggtggtcg atcagttctt ggtaccgtct
     4561 cagcttcgcg gcataataac caccaacgga atggtgatag tacgaggtcg ttgtctccaa
     4621 gaaaggatta ttcaaattca agacacgata agaaaggtcc ttatccttca tgatttcttg
     4681 atcggctacc gtctctttat atacctctgt aggtttctgg cggataaagt tactatcgtt
     4741 caaataccgt ttatccaccg tccataagtc aaccaacatc aagaccgcaa caccgatccc
     4801 tacgaatgtc gccacctttt tccgatcttt cgaggtatag aaccagaaca acaaagccgc
     4861 ccctaataag ataaagacca aagagcgcaa cgcatccgcc gaagccaagg aagcacgatc
     4921 cattaacaag gcgttgtaat accaatctgg caactgatat tgagcgtcga aagaagaacg
     4981 gaaatccaac agcatactcg gcatcaacca aaggattaaa gaaatgcccc ccgtgatagc
     5041 caaagcagcg atcaatcctt tcttcaacaa ggcatcgctc acggtctcgg ataacacctc
     5101 tttcaatccc catatagcga taataggaaa taccataccc ggaataacca atgccatctc
     5161 tacggtacgg aacttattat acatcggcaa gtaatggaac ataaagtcat tgaagctatc
     5221 aaaattacgt cccaatgcca gcaatatcaa aaagacagaa cctccgaata accaccattt
     5281 catcggattc cggatcacga acattcccag aacaaacaag aagcagacca atgccccgaa
     5341 ataaaccggc ccggaagtaa atgtcttctc tccccaatag gtaggagcct gtacctcttt
     5401 tccgacttga gcgcctttcg cccttaattc cttatatagc tcagaatccg ggcctagcat
     5461 tccacctgaa cttccaccat aggcattcgg gaccaacaag gtcaacaact ccccttttcc
     5521 atagctccaa gcgaacgcat aatccttgtc taagccggaa gaaatcttct cgcccgaagg
     5581 ggtcgttgtc gttaattccg tagccccacg gatagagttc tgtcccaaat cccattgagc
     5641 atacatattc tgggcattcg gcaacaccgc caatatcacg catccagcca taatagcggt
     5701 taccgtaccc agttctttat aagctttttc cttcagttta ttgaacaaat atcccaaata
     5761 aacgaagaag caaagtaata ataaataata agtgatttgc aggtgcgtat tcgcgataga
     5821 gaatgcgaca cccaacaaga acacgaccgc cccccataaa tacttacgct tgaacaacag
     5881 ggccataccc gccaacgtta atggcatata agcgattaca tacgctttcg tgacatggcc
     5941 ggcctctata atgatcagat tataagatgc taaagcgaaa gcgatagcac cagcgatcgc
     6001 caaccaccaa tttacgccca tgacacacat caagatatag aaacaaacga atccggtaaa
     6061 caccatcccc gcatccatat accccagcgc ttttaaaggc ttctccacta aaagatatcc
     6121 gggaaatcgt ggagccggat ttccatatcc cgacacataa ggcattccgc caaacatagc
     6181 atcagaccat gcgctgaatt ctcccggttg ggccgtcttc tcatattcat ccatctggct
     6241 attccccata ccgatagcct tttccgtatc cccttgccgg actaccttac cctcaaatac
     6301 ggccggagaa aaataaatca ccgtcaatac caagaatacg gctatcgctg cgatatgttt
     6361 tccccattta ctcattatac tccgcataaa acttatctat aatttattgt ttatactcta
     6421 cctttaaacc atttggcaaa atagaatctc acggcgaacc aaccatgcaa cagaatcgtc
     6481 gacaccttgc cataatactt acacatgacc tcatatcgct cctttaagga agctttccgg
     6541 ttcacactac ttaatccttc ctctaaaaaa ttagacaggg tcaaacgtgt attatgtatt
     6601 cttttcgatc gtctcagaca ttggatacac caatcataat ccgccgtcaa acggtattcc
     6661 gtattatata acggagcgat ctcccgtttt gatataaacg actggtgaca aaccaacatt
     6721 cccatccgga aacttttcca agtcagtttc tccggtgctt tcaatctgcg catccctaat
     6781 gatctaccct ccgcatcaac gatctgggtc tctccgtaaa tcacgtctgg caaagatact
     6841 ttctttttca aagacgccac aattctttgc acggtatctg cggtataaag tgtatccccc
     6901 gcattcagga accacacata atcccccgta gcccgcttca atcccttatt catagcatca
     6961 tacaagcctt tatcaggctc gcttatccaa gaagcgatac cggactcata ttgcttgatg
     7021 atctctacgg tcttatcctt cgacgctccg tcaatcaata tatactcgat attcggatac
     7081 gactggctaa gtacgctcaa tatcgtacgc tccaaccatc gctccgcatt ataggtgatc
     7141 gttatgatcg aaaatgtagg ttgctgattc atttccatta tctcttataa atttccgact
     7201 tgtctcacac gatatttttg taaaggatgc ttaggagaag acggatataa tctctctagt
     7261 agcccatcct ctaacattct tggtataacc cgattaatta aataagaagc ctctctatga
     7321 acagcttccg ctattatttc cagagctaca taatcctcac aaacagatag tattaacctc
     7381 gacaaatcct cataacgcat atatttctta ctttcatcct tctccagttt gctttcatct
     7441 ttttgagact tgctttcatc cttcttcagt ttgctttcat ccttttgagg cttgctttca
     7501 tccttctcca aaaacagcaa acggtaccta gttccccggc catttcctat agactccaaa
     7561 aaaccagcat tgcacatact ttttagtagc tttgtaatat ttgagctatg ttggttcaaa
     7621 atatattgaa gtctttcatt agatacttgt ttttcagagt aacaaagagc caaaaccgtg
     7681 aattgatcat atggaattct ttcaatttcc cgtccaaaca gacgcttaag ttcttctaag
     7741 acttcctctg gatacaaact ttccatcggt aaattcaaca ccacccgatc cgggtgactt
     7801 tgctcctcca caaatggagg tctccaattc gcatttttcc aacccataaa aatcttattc
     7861 accccacttc ctgctttctc agagaagcca atcagcataa acatcttttg caagctctta
     7921 ttacggcata tactttcacc tccggcataa tactgggcct tactcactag cagtgttccg
     7981 ggatttttaa atacataacg atctttccat tgttctatcg ttatatttcc ttcctccata
     8041 taatcacaat gcaccaatgt atttacaaat gcctcacgta aagcgacatg cgtggtagta
     8101 tcttccaatc tcacaccatt ctccaaacgg aatggcttag gcagtacaga tgataattta
     8161 ggatacacac gccgataaaa ttgaaaaaga ttcgcttccc aagttccatc catacaaatg
     8221 cgatctgtcc atctaacatt ctcatctacc gacatttttt cctgataatc cggaaaataa
     8281 gatggagcac attcattatc cgttatactt tctgtccttc caaacattaa tatacccgct
     8341 aaagtaaacc cttcttgacc tgtttgccta tcttgtcgat atcctcccaa ttttctcaaa
     8401 aaagccatat catcaagtgt caaccaaggg tgatctggct gacgactaga aagtagcagt
     8461 cgatattgtt taagtgagtc caaatcaata tcttccattg aataattaca taaaatacga
     8521 gaatctctcg gatgttcctc atccgcatcg gcaatcattc tgcgaacttc cgtatccgta
     8581 catttataat ctccctcatt atttcgttta taagtatgtc cattcaaggg atttcttgtt
     8641 aaatatacag gacgttgtga acgagatgct ctcggaacat aaatcagcaa aagagatttt
     8701 cctctatagt ctacctcttg aatattcttg tcagtaagta aattaacatt aacgcaatcc
     8761 ggattattca attggttaca aatgatttgc cgataagaca caatttgctc tggaagaagt
     8821 ccctccacaa atagtgcccc atttttctcc tttattccca gaacgatagt tcctccatct
     8881 gtattcgcaa atgaagaata cgtttcccac acactatttg ggaatccggc acgagcggtc
     8941 ttaaactcta aatcgacagc ctcttgacta cgcaacaagc tatccacata ttctacaaaa
     9001 tcccactcgt ccaccttaat ccattcaggc ttatgctgat cgtccattta ttccattttt
     9061 ccacaaatgt agcaattttc atttgctttc aatcacttac cagcaagcat tcattcttac
     9121 ttcgatatgc tgatcttctt tcacgctatt ttctcttatt acacaggctc tgatacaaag
     9181 ctatatattt ttcggcaata accgattccc tatagcaatc atgcaccttg cggacgcaag
     9241 cctcactaaa tcgaaaagtc tcttggttgt caattatcca cttaatccct acagccaaat
     9301 catttgtatc cttatattta gctacatacc cattcttcaa atgatctatc atctccggaa
     9361 tccctcctgt ctcaaatccc acacaaggcg taccgcatgc catcgactcc ataatcgtat
     9421 tgggtaagtt atcctccaac gaaggaataa cgaacatatc ggcacaggca taaacggaaa
     9481 tcatagagtc ttgatccgat atatatccca gcgtattcac cttaaaagga aactggctaa
     9541 tcaattcttc cgagctattt cccatcaaca cgatttctat gcgatcttgg tatttctctt
     9601 ttagtttttc gcaagcctcg atcaaaaaaa tcgctccttt ccgggtatct gaaagcttag
     9661 cggcggcaaa aagaagaagg aacttacctt ccggcaggtc gaatcgttta cgggccaccc
     9721 gcttttccat acgcttaaag gctgtcacgt caatcgggtt aggaatcgag gtaaaacagg
     9781 ctgttctcaa ccaattgcct ttttgggcct cttccattat ccatcggcta caaccgacaa
     9841 atgtaatctt agataaccct attttccctt tctccttaaa aacagaagcc gctaaatcaa
     9901 aaaacggatt tcgtttcagc atcgggcact gataacaatt cgatatatac ttctcacatc
     9961 ctcccggata atgacaaata gccgtagctg gccacaaatc atgcatagtc cacacaatag
    10021 gttttccggt atttactaat ttcttaatat cagaaagaga caaaaatcct tgattcaccc
    10081 aatgcagatg aatcacatcc gcctgttgca ctaatgggtg cttcgataaa tccgtgcctg
    10141 tattggctat ggaaacttga aagaggttct tcttgctaaa gaagttacag ataaagatta
    10201 tcagtcgttc ccaaatgaag cgaaaagaat taagcctatg tgaagtccat gaattattta
    10261 cagagaaaac ttttacatgg tctgttttcc gatcacgtac taacatagaa acctctacac
    10321 cagatttacc caatgctttc gctagtcggt ttgcggcgac tgccgctcca ccggttaatt
    10381 cagaggtatt taatatcaat atcttcatga cttctctatt attttccaat aaccattttt
    10441 cctagctcca atgcgttcaa tccaaccatg ctctttcaac ttttttataa gcttccggat
    10501 atactgctct gtcaaatcca aacgatttgc taaatctatt tgacggatag taggctcctc
    10561 tcgcaagatc tgatatacct cccgttccat atccgacaat tcatttatcc gctcatttat
    10621 ccgctcattt atccgctcat ttatccgctc atgaaaaaaa gtcaagtata aaaaacccat
    10681 cttatgctca tatacaggag cggataatcc ttctgccaag cagttgtcaa taatacgttg
    10741 tgttccccgt ccccaactct cgataaagcc agctttgtaa aaaacatccg ctatcaactt
    10801 attatgaggt ctagaggggt gaggacgaga caagtcctca accgtaatat cgtgcaaacg
    10861 agcttcattc cctatcacca gcttgtcctc gtaaacacgt acctgaattt cggaagaaac
    10921 aaaatattct cgatggataa tcgaattcaa taaggcttcc cgcagagcct cgtagggata
    10981 aaccagtttc tcacgcctat gaatcccctc atacgatata taacttaata aatatttcgt
    11041 tcgcaatata tccaaagccc gatcaacctg ctgaatcagg ttcccctcga caatatcggt
    11101 tgtcagtacc tccgtatcgg taaggaactt tcctatttta atacgagctt gtaacacata
    11161 tctctgcaca ttctttccaa acaagactac agcggctctc ttgaaacggc ctcctacgat
    11221 caaattcaac cgctccatca aagccagcag atccgtttcc tgctcgatgg aaggaacccg
    11281 gtctttagcc aatagcttaa aacgttctac cgtatcggta tctatgtcct ccaatgagaa
    11341 atcctcctcg atcacacttt cccatgtcaa acccattttc gcagccaaaa acatatttag
    11401 ctgattccct tgtagctcgg aagtaacgct tccactccgg gtataatacc gtccatgcac
    11461 ggaaatcggc atggcagaag gttggacttc tatttccaaa tattctttac cggccttctc
    11521 cctcaaatgg ataagaggca taatacccgt tttctgagcg ataaagttcg gcagtttctc
    11581 aatcaacttc tttggctgct ctatccctac aacttctcct ttatcatcga taccgatata
    11641 taatacacca ccctccgtat tacagaaagc tgatatataa cgggtatatt cgtcatgcca
    11701 tgactctttg aattcggtat gttggttttc ttccataatc taaaattata tcaaactttt
    11761 tttctaaata tcctccgaac acaagtattt aatttaacta acaaggaata tggtaaacaa
    11821 tttaaaaaca aatgatagtt acaatccaaa ttcaataatc cccaaggcaa taaacgtata
    11881 tactccaaaa atgcactttt cttatcatta tcaaaaacaa agattacaaa tcttatcttg
    11941 taccaaagat aaacataatt atctaagtct tttatctgat aagagcagtt tagcctccaa
    12001 agctctatac caacatagtc ttcttttatt gctggctgca tatttttctt aacactcaaa
    12061 tagcaactgc tatctcttct atacaatgct aggtttgatt tcgaataagc tattttatac
    12121 aagcaagcta atttagccca aacgattaca tcttcaccta aagaaatgcc ctcagggaaa
    12181 caaccaatag ataaaatagc cttttttcga acagccacag ctgaagtcca aataggtcct
    12241 ctcgcttttg aggccatcgt aaaataatta tctaaaatac cctcattctc tttaaaagaa
    12301 taataatcaa ttgatgcggg agttatcata ttattcatct taaatgaata agctgtacca
    12361 aaaatatcac attccggata tttttcaacc aagaaagcga tagtttttaa ataatcaggt
    12421 aaccactcgt catcagcatc aagaaaggca ataatctcac ctctagcttc tttaatacct
    12481 tggttcctcg ctgcagaaac acctttgttc tcctgttcaa tcaatcgaac tgaattttta
    12541 aacacagctt cattttctga aagaaaatcc atcaaaacag
//
