LOCUS       c00019_gnlPro..        13974 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|DHNHCICD_19.
ACCESSION   c00019_gnlPro..
VERSION     c00019_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-07 08:04:18
            Original ID  :: gnl|Prokka|DHNHCICD_19
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13974
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..93
                     /locus_tag="ctg19_1"
                     /transl_table=11
                     /translation="IVALFRFSVNKNLFENFCYFKNMRIYSMRK"
     protocluster    1..13974
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[484:3974]"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      485..3974
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
     cand_cluster    1..13974
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /kind="single"
                     /product="Fumarate2succinate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..13974
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Fumarate2succinate"
                     /region_number="1"
                     /rules="(Succ_DH_flav_C and FAD_binding_2 and (Fer2_3 or
                     Fer4_7 or SucD_FumR))"
                     /tool="gutsmash"
     CDS             complement(485..1315)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Fer2_3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_8"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052:Succinate dehydrogenase-2Fe-2S iron-sulfur
                     cluster binding domain (Score: -1.6; E-value: 9.2)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg19_2"
                     /sec_met_domain="Fer2_3 (E-value: 2.5e-23, bitscore: 74.1,
                     seeds: 38, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_8 (E-value: 8.1e-11, bitscore: 34.2,
                     seeds: 153, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 4.4e-06, bitscore: 19.0,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LPSAATSKDSQYINTQKKDYNMAKTLNLTLKVWRQENREAKGRIE
                     TYAAKDIPVDASFLEMLDIVNEGLVKEGKEPIHFDHDCREGICGMCSLTINGIPHGPER
                     QVTTCQLHMRKFKDGDTVWIEPFRAKAFPILRDLMVDRSALDRIIAAGGYIDVRTGSAP
                     NANNIAVEKVKADAAFDAAACIGCGACVASCKNASAMLFTSAKIAHLNLLPQGQPERSK
                     RVLAMMKQMEAEGFGNCTNQYECEAACPKGISVDNIARLNRDFMRANAKEGLCF"
     CDS             complement(1293..3251)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: FAD_binding_2"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Succ_DH_flav_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1027:FAD binding domain (Score: 176.1; E-value:
                     4.2e-54)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg19_3"
                     /sec_met_domain="FAD_binding_2 (E-value: 3.9e-54, bitscore:
                     176.1, seeds: 62, tool: rule-based-clusters)"
                     /sec_met_domain="Succ_DH_flav_C (E-value: 1.1e-37,
                     bitscore: 120.8, seeds: 739, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINFPVSDWMPDAKIPSGPIQDKWSKYKLESKLINPNNKRKYTVL
                     VVGSGLAGASAAATLAELGYNVKCFCYQDSPRRAHSIAAQGGINAAKNYQNDGDSVYRL
                     FYDTVKGGDFRAREANVYRLAEVSSNIIDQCVAQGVPFGREYGGLLDNRSFGGAQLKRT
                     FYARGQTGQQLLLGAYQALEKEVAKGHIEMFSRHEMMDLVLVDGEAKGIVTRNLVTGEI
                     KSYAGDTVLLCTGGYGNVFFLSTNAMGCNVTAAYKAYKRGAFFANPCFTQIHPTCIPVK
                     GDYQSKLTLMSESLRNSGRIWVPKSRETAEKIRKKEIKPSDVPEEERDYYLERKYPSFG
                     NLAPRDISSRAAKEACDDGRGVAVTGKGVFLDFADEIKRMGREWIDGQYGNLFDMYEEI
                     TDDDPHETPMMIYPASHYTMGGLWVDYNLMSNVKGLHVLGEANFSDHGANRLGASALMQ
                     GLSDGYFVIPATLPAYLTTTKPGAVTTAAPEFKAAEDEVKERINKLLNVKGTKTVDSFH
                     RELGLIMWEDCGMARTEESLTHAIERIPQLRKEFWENVRVTGTADGINAELEKACRVAD
                     FLEFAQLLCYDALNRQESCGAHFRVEYQLPDGEAKRNDDEYAYVAAWEYTGVDSLPVLH
                     KEPLTFENVHLAIRSYK"
     CDS             complement(3273..3974)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: SucD_FumR"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg19_4"
                     /sec_met_domain="SucD_FumR (E-value: 2.4e-13, bitscore:
                     42.0, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNALVKTICTFVTSSIGRKIIVALTGLCLVLFLAGHLAGNLLIFG
                     GPEWINTYAHGLHSMPEAALWGIRAGLAVIFIIHVWLTIQLKLENHAAREPYVFKNTIK
                     ATLSSRYMIYTGLTVLVFLIYHLYQYTLRVGYDPAQFTTFISDGTVETFDVYKMIVTGF
                     SNVWCSAFYILAVLMLFSHLRHGVQSIFQTVGVDSRKIRPFYNFIAIAYGAIICLGFIS
                     VPVSVLLGIIK"
     CDS             4175..4447
                     /locus_tag="ctg19_5"
                     /transl_table=11
                     /translation="MKRSKKEVLDADFAAARAGVLDVAAFLDRVDRGEGEADFRYHALM
                     DVLPLLSASGPGRVRAILEALSYRDDTVPETAAAKAACGAPNLSK"
     CDS             4450..5265
                     /locus_tag="ctg19_6"
                     /transl_table=11
                     /translation="MMAFIEPHIHMVCRTTDEYRAMAQAGCLAVGEPAFWAGYDRSSAD
                     GFRDYFVQLTECEPARAAKFGMDHYTWLCINPKEAQDVAFARDVMKLIPEFIDRPNVLG
                     IGEIGLNRNTSHEMTIFEEHLDLAVRLNQLVLIHTPHLEDKLKGTVMILSALKNRPDLD
                     PCRVLVDHCEEHTFPLVKEAGYWAGLTLYPTSKLNPKRAADILELYGMDRVWANSAADW
                     GDSDPLALTALACELRRRGFSRQETERLLLENPETFMGQSPKFRKVSSR"
     CDS             complement(5299..5706)
                     /locus_tag="ctg19_7"
                     /transl_table=11
                     /translation="MQSPASLSIRNSPSFQQSISPHGPDRCGSVRRQQTPSPKQGKGVG
                     KWLSLNLYPPFPSMNLQKQQLLLRLFRYFKSRKGEPRFFNKRNICLLAAAGAYILTPDE
                     FLFDGIGRLGLLDDAAVILGAVLTVFFPDGD"
     CDS             complement(5971..6678)
                     /locus_tag="ctg19_8"
                     /transl_table=11
                     /translation="MKKLLSTLILSAGMSLSATANTTLLDSSIVGYSDFTSQTADFGTL
                     KDSVSITSDDSNLTLSGITFNGYGTNNRDVMSVTMVLDLSKINTPETYTALFNAKNSSV
                     SWGVGLNTDRKLQGLWNNTSYSGPVVDTPLGMEGSLTISVVTGDLGTRIYFGDSATYYS
                     NSGLKFGNQQIDQILMDAGLAESIEQLYIHDSLLSQEQVGQLMSEIASIPEPATASLGL
                     LGLAALMMRRRRA"
     CDS             complement(6709..6798)
                     /locus_tag="ctg19_9"
                     /transl_table=11
                     /translation="MNYKYNILTLNIFNCLRIPNSLFKRKCIH"
     CDS             7003..7713
                     /locus_tag="ctg19_10"
                     /transl_table=11
                     /translation="MGSFAVSSEAATVFNYYTPGTDNYNSTIHGFYLGLGSSSLAPSDS
                     SSPSSLSGEIRLDSFTLRGAANNLGANVTYGFLVLNGSDNSVIGWSTNTGTTAAGINLT
                     FSFSSLDGSPLLLDAALTYRFLAVSQSVMDLMQDTSKTYLYAAGGTAAPTANTEGDTVT
                     ISGGLTAPGIRGHYDAEGAPGDSVVITGANGTNTFSLLSPIFTEIRGEMVPEPATVSLG
                     LLGLAALMMRRLRA"
     CDS             complement(7931..8065)
                     /locus_tag="ctg19_11"
                     /transl_table=11
                     /translation="MYAAALQVCELQRGSLSGLKGHYVKAAVYHMDEKRAAEFDGISR"
     CDS             complement(8177..8377)
                     /locus_tag="ctg19_12"
                     /transl_table=11
                     /translation="MTIALRTEQSSDHAETEHVTREAFWNYFVPGCHEHYLLHIMRVSP
                     SFIPELDAVAVHGSRIVGKHR"
     CDS             complement(8391..9596)
                     /locus_tag="ctg19_13"
                     /transl_table=11
                     /translation="MRGIFLVSCFLGGSALLAGCREENNSPRPATEDAARITSARQWGE
                     SRSALQKRELDRAAGPALPIPDDLPSRELVGTTRQIHQLIEASGNPARFESYTETVPVA
                     EASLRMVAIPGGTFLMGSPAEEPHRKPDEGPQHKVSISPFWISETEIPWELYTAFMENG
                     RPRAKDGQLLEEQPDDELWDSVTQPTAPYTAMNLGMGHGYEHGLPAISMSHHAASKFCE
                     WLSAQTGHYYRLPTEAEWEYACRAGSPGAYSYGNGEASLDQYAWYWNNSNDRYQKTGSK
                     KPNKWGLRDMHGNVAEWVLDSYVPDAYGKRSGLPAKDPLVIIPSAPHIVRGGSWEDDPD
                     SLRSAARRASTPAWNRQDPQNPKSIWYLTDGGMIGFRVVRPMNIPDIMTMHRLWNFSKG
                     EP"
     CDS             complement(9620..10549)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short_C2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg19_14"
                     /sec_met_domain="adh_short_C2 (E-value: 4.7e-75, bitscore:
                     244.0, seeds: 358, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKTGRPPVHSGKMKRPDSSPPPRFSPLFFHSRHAPSPYGFLRGQV
                     HFKLAGTVKNGFTVGSMQKLAGKTAIVTGAGRGIGNAVARRFASEGARVILISRSPSSC
                     GGAAEEINKEFPDSCKAYPCDVADYAAVQETMAAILKDFPQIDILVNNAGITRDSLMLR
                     MKEEDWDAVLDTNLKSAFNTVKALQRVLMKSPAGRIINMSSVIGLVGNIGQANYAASKA
                     GLIGFTKSLAQEFAPRKVTCNAIAPGFISTEMSNAIPDNLKEEIVKKIPLKEQGSVEDI
                     AALTAFLASDDARYITGQVIACDGGMTM"
     CDS             complement(10494..11012)
                     /locus_tag="ctg19_15"
                     /transl_table=11
                     /translation="MKAFLVPLLYSALLSGASLAFGETAAGTASPAAAAPAEKIPSAES
                     LINQAFSFAINIQQTLAGVQDKESVDNAVKTLQDIQKDIRHFLQLQDKLNDAEKEKEDA
                     LIEKMEKRMEMLDNRCRQEGKRLFEARYYGSAALKDILENSDEFSDLVEPDEDGAPPGA
                     LRENEEAGQ"
     CDS             complement(11076..12686)
                     /locus_tag="ctg19_16"
                     /transl_table=11
                     /translation="MLTIKNLTKSHAGRTLFRETEMTINWGERVALVGPNGAGKSTLFR
                     MILGEDTPDEGSISMDEYAIVGYLPQEASEPKDETVLEIALGITPEMEQAIHTIRTAEN
                     ANKTDTPEYAEAIDTFNAANGYQLEPKAKKILKGLAFRESDFHRPAREMSGGWIMRAYL
                     AKLLVLEPDLLMLDEPTNHLDLLSLLWLQRYLKNYPGAILMISHDRDFMDELVESVYDI
                     DNEELVEYRGNYSDFLQQKDVRFEQLQAAYRNQQKEIAHIQEFIDRFRSINSKAGQVQS
                     RIKQLEKMKIIQKPVARRKVFKFNFPQPPRSTQKVIELEKVCQSYGDRRVYENLDLLVE
                     RGERTVLVGPNGAGKSTLLKILAGIIPIDSGQRTPGTTTRIGYFSQARTENLNPENTVL
                     EEIMKCSAEIREEEARSILGSFLFRRLDVEKRVSVLSGGEKSRLSLVKFLVDPPNLLLM
                     DEPTTHLDLLSVEALVQALKHYEGTLVFISHDVHFIRSLAQKTLHVNRGTITAYAGGYD
                     YYLEKSGILDDEKGGITAE"
     CDS             12926..13516
                     /locus_tag="ctg19_17"
                     /transl_table=11
                     /translation="MSGLANAFLALLPPDQASLPAAGAEARWLADTAVVQSAAIARDNR
                     TVLFGWLNNILVNSNLRDRGLCWQVQQDLYRDLRRRPVKYFRIGLTIRDRGTGREHSCV
                     YVNAVGKGLQGSIVLDAWKNCGHLVTLTQKDREGGKWEEDWREPFVSKAFPEGHSYGME
                     HHLVWPGWARKRPMLVQRIFQSDQQNEAKAAAE"
ORIGIN
        1 atagtagcat tattcagatt tagcgtcaat aagaatttat ttgaaaattt ctgttatttt
       61 aagaacatga gaatttattc catgagaaaa taatattata attcttacgc tcagtgcatt
      121 cccttaatag acatcaatgt tgtctgtttg ttagaaaatg ttttcctctc atgctgagcc
      181 cttgacagga ggccatccct tccgggcatc agtctaattc ctgtaatcaa tgtttttctc
      241 tctcgaagaa agatggggcc gtcgctgtcg gacggggcct gcttaggttt cgtccggcat
      301 ttccaagtac ggtttcctgg attactgggt gccttccggt gtaacaattt tttacgctgc
      361 gcgacgatga ggaagcaact gtctggtatt ttattcctgg ttcaaggaaa tctggtaatg
      421 aaaaaactcc cgacagccga tgccgccggg agtttttaca gagcgtctta agaaggaatc
      481 ttctttagaa acagaggcct tccttggcgt tggcccgcat gaagtcgcgg ttgaggcggg
      541 cgatgttgtc cacgctgatg cctttcgggc aggcggcttc acattcatac tggttcgtgc
      601 agttgccaaa gccttccgct tccatctgct tcatcatggc caggacgcgc ttggaacgtt
      661 ccggctggcc ctgcggcagc agattgagat gggcgatctt ggcggaggtg aacagcatgg
      721 cggaagcgtt tttacaggag gccacgcagg cgccgcagcc gatgcaggcg gccgcgtcaa
      781 aggcggcgtc cgccttcact ttttccacgg cgatgttgtt ggcgttcggc gcggaaccgg
      841 tacgcacgtc aatatagcct ccggcggcga tgatgcggtc cagggcggag cggtccacca
      901 tcaggtcccg caggattggg aaagccttcg cgcggaaggg ttcaatccag acggtatcgc
      961 cgtccttgaa cttgcgcatg tgaagctggc aagtggtcac ctggcgttcc ggcccgtggg
     1021 gaatgccgtt gatggtcagg gagcacatgc cgcagatgcc ttcccggcag tcgtggtcaa
     1081 aatggatggg ttccttgcct tccttgacca ggccttcatt gacgatgtcc agcatttcca
     1141 ggaaggaggc gtccaccgga atgtccttgg cggcataggt ctcaatgcgg cccttggctt
     1201 cccggttttc ctggcgccag accttgagag tgagattgag tgttttagcc atgttataat
     1261 ctttcttttg agtgttaatg tattggctat ctttacttgt agctgcggat ggcaaggtgc
     1321 acgttctcga aggtcagcgg ttccttgtgg agaacaggca ggctgtccac gccagtgtat
     1381 tcccaggcgg ctacataggc gtattcatcg tcgttgcgct tggcttcgcc gtccggcagc
     1441 tggtattcca cgcggaagtg ggcgccgcag gattcctggc ggttcagggc gtcatagcag
     1501 agcagctggg cgaattccag gaagtcggcc acgcggcagg ctttttccag ttccgcgttg
     1561 atgccgtccg ccgtgccggt tacgcgcacg ttttcccaga attccttgcg gagctgggga
     1621 atgcgttcaa tggcgtgggt caggctttct tccgtgcggg ccatgccgca gtcttcccac
     1681 atgatgaggc ccagttcccg gtggaaggag tccaccgtct tggtgccctt cacattcagg
     1741 agcttgttga tgcgttcctt cacttcgtct tccgcagcct tgaattccgg ggcggcggtg
     1801 gtgacggcgc cgggcttggt ggtcgtcagg taagcgggca acgtggcggg aatgacgaag
     1861 tagccgtcag acaggccctg catcagggcg gaggctccca ggcggttggc gccgtggtcg
     1921 gagaagttgg cttcaccgag gacgtgcagc cccttcacgt tggacatgag gttgtagtcc
     1981 acccacaggc cgcccatggt gtagtgggag gcggggtaga tcatcatggg cgtttcatgg
     2041 gggtcgtcgt ccgtgatttc ttcgtacatg tcaaacagat tgccgtattg gccgtcaatc
     2101 cattcgcggc ccatgcgctt gatttcatcc gcaaaatcca ggaagacgcc cttgccggtg
     2161 acggccacgc cgcggccgtc gtcgcaggct tccttggcgg cgcgggagga aatgtcgcgc
     2221 ggagccaggt tgccgaagga gggatacttg cgttccaggt agtagtcccg ttcttcttcg
     2281 ggaacatcgg aaggcttgat ttccttttta cggatttttt ctgcggtttc acgggacttg
     2341 ggcacccaga tgcggccact gttgcggagg gattccgaca tcagcgtcag tttggactgg
     2401 tagtcgccct tgaccggaat gcaggtgggg tggatttgcg tgaagcaggg gttggcgaag
     2461 aaggcaccgc gcttgtaggc cttgtaggcg gcagtgacgt tgcagcccat cgcgttggtg
     2521 gacaggaaga acacgttgcc gtagccgccc gtgcagagca ggacggtatc ccctgcgtag
     2581 gatttgattt cgccggtaac cagattgcgg gtgacgatgc ccttggcttc gccgtccacc
     2641 agcaccagat ccatcatttc atggcgggag aacatttcaa tgtgtccctt ggccacttcc
     2701 ttttccaggg cctggtaggc acccagcagg agctgctggc ccgtctgtcc gcgtgcgtag
     2761 aaggttcgct tgagctgggc gccgccgaag gagcggttgt ccagcaggcc gccgtattca
     2821 cggccgaagg gaacgccctg ggccacacac tggtcaatga tgttggagga gacttccgcc
     2881 agacggtaga cattggcttc acgggcgcgg aagtcgccgc ctttaacggt gtcgtaaaac
     2941 aggcggtaaa cggagtcgcc gtcgttctgg tagttcttgg ctgcgttaat gccgccctgg
     3001 gccgcaatgg agtgggcgcg gcgggggctg tcctggtagc agaagcattt gacgttgtag
     3061 ccaagttcgg caagcgtggc ggcagcggag gcgccagcca ggccggaacc taccacaagc
     3121 accgtgtact tgcgcttgtt gttcggattg atcagtttgg actcaagttt gtacttggac
     3181 catttgtcct gaatagggcc ggagggaatt ttggcatccg gcatccagtc gcttacggga
     3241 aaattaatca tgactttgag aggagttgat ggttatttga tgatacccag aagaaccgag
     3301 accggcacgg agatgaagcc caggcagata atcgcgccgt aggcgatggc gataaagttg
     3361 tagaagggcc ggattttgcg ggaatcgacg cccacagtct ggaagatgga ctgtaccccg
     3421 tggcgtagat ggctgaacag catcagaacg gccaggatgt agaaggcgga gcaccatacg
     3481 ttggagaatc cggtcacgat catcttgtac acgtcaaagg tttccaccgt accgtcggaa
     3541 ataaaggtgg tgaactgggc ggggtcgtat cccacgcgca gggtgtactg gtacaggtgg
     3601 tagatcagga acaccaggac ggtcaaaccg gtatagatca tgtagcggga ggagagcgtt
     3661 gccttaatgg tgttcttgaa cacgtagggt tcgcgggccg catggttttc cagcttcagc
     3721 tggatggtca gccagacgtg gatgatgaag atcaccgcaa gccccgcgcg gattccccag
     3781 agggctgctt ccggcatgga gtgcaggccg tgggcgtagg tgttgatcca ttcagggcct
     3841 ccgaagatga gaaggttgcc tgccaggtgt cccgcaagga acaagaccaa acataacccc
     3901 gtcagagcca caatgatttt gcggccgatg gaggatgtca cgaatgtaca tatggttttt
     3961 actagtgcat tcataggcgc tctaatgaaa taaatgcgtc ttcacaggat gcccggttca
     4021 agcccggatg gcaagcctct tcttgaattt ccggcgcttt tcggattttt gaaaaaccgg
     4081 ggaaagaggt tgctgtttat cagtttggaa tggttatcat tttgttgcct gttccggctt
     4141 gacgaggctt tccgcatagg cgtatcgtct gtgcatgaaa agaagtaaaa aggaggtgct
     4201 ggacgcggat ttcgcagcgg cgcgcgccgg cgttctggat gtggccgcat ttctggaccg
     4261 ggtggaccgc ggggaagggg aggcggattt ccgctaccat gccctgatgg atgttcttcc
     4321 cctcttgtcc gcatccggcc ccggacgcgt ccgggccatt ctggaagccc tttcctacag
     4381 ggatgacacc gtgccggaaa ccgccgcagc caaagcggcc tgcggagccc cgaacctcag
     4441 caaataagaa tgatggcttt catagaacct catatacata tggtgtgccg caccacggac
     4501 gaataccggg ccatggcgca ggccggctgc ctggcggtag gggaaccggc gttctgggcc
     4561 ggttacgacc gttcgtccgc ggacggtttc cgggattatt tcgtacagct tacggaatgc
     4621 gaacccgcca gggcggccaa gttcggcatg gaccattaca catggctgtg catcaatccc
     4681 aaggaggcgc aggacgtggc tttcgcgcgg gatgtgatga aactgattcc ggagttcatt
     4741 gaccggccca atgtcctcgg catcggggaa atagggctga accggaatac ttcccatgaa
     4801 atgactattt ttgaagagca tctggatctg gcggtgcgcc tcaaccagct tgtgctgatt
     4861 cacactcccc atctggaaga caagcttaag gggaccgtaa tgattctttc cgccctgaaa
     4921 aaccgtccgg atctggaccc ttgccgcgtg ctggtggatc actgtgagga acataccttc
     4981 ccgctggtga aggaggccgg ttactgggcc gggctgaccc tttatcccac cagtaagctg
     5041 aatcccaagc gggcggcgga tattctggaa ttgtacggaa tggaccgtgt ctgggccaat
     5101 tccgcggcgg actgggggga ttccgatccc ctggcgctga cggccctggc ctgcgagctg
     5161 cgcaggcgcg gtttttcccg gcaggaaacg gaacgtcttc tcctggaaaa tccggagaca
     5221 ttcatgggac agtccccgaa gttccggaaa gtgtcgtccc gctaattccg cccgaggcgc
     5281 ggcggagggt acggccctct agtccccgtc cgggaaaaag acggtgagga cggcgcccag
     5341 gatgaccgcc gcgtcatcca gaaggcccag cctgccgatt ccgtcaaaca ggaattcgtc
     5401 gggagtcagg atgtaggcgc cggcggcggc cagaaggcat atattccgtt tgttgaaaaa
     5461 acgcggttct ccttttctgc ttttgaaata ccggaacagg cgcagtagca gctgctgttt
     5521 ttgaaggttc atggacggga acgggggata aaggttcaag ctcagccatt ttcccactcc
     5581 ttttccctgt ttcggggaag gagtctgttg ccgacggacg gaaccgcagc gatccggacc
     5641 gtgcggggaa atggattgct gaaaggatgg gctgttccgg atgctgaggg aagccgggct
     5701 ttgcatgctc cggttccggc tgtcccggca tgggaaaaag gggcgtgtac ggaagtgggg
     5761 cggggccgga agctcttgaa atgaccctac cgggggagac tgaatgctat ttttccgtca
     5821 agtgctggcc gtgaggttgc cgcagcaaat ggaagctttt cccctctgtt ttttcggcag
     5881 atgtttgaac ggataaggaa aaggccggct cacgattttg tgagnnnnnn nnnnccggcc
     5941 tttgaatata gggaggcgga cggtacaggc ttatgccctg cggcggcgca tcatcagcgc
     6001 ggccagtccc agcaggccca gggaagccgt ggcgggttcc ggaatgctgg cgatttcact
     6061 catcagttga ccaacttgtt cctgggaaag gagggagtcg tggatgtaga gctgttcgat
     6121 ggattcagcc agtcctgcgt ccatgagaat ctgatcaatt tgctggttgc cgaatttcag
     6181 gccgctgttg gaatagtacg tagcgctgtc gccaaaatag atgcgggtgc caagatctcc
     6241 ggtgactacg gaaatggtca gggacccttc catgcccagc ggggtgtcaa cgacgggccc
     6301 gctgtatgag gtgttgttcc ataatccctg gagtttccgg tccgtgttca ggcccacgcc
     6361 ccagcttaca ctgctgtttt tggcgttaaa cagagcggta taggtctccg gagtgttgat
     6421 tttggacaga tcaagaacca ttgtcacaga cataacgtcg cggttgttgg taccgtatcc
     6481 gttgaaggtt atcccggata acgtcagatt gctgtcgtca gacgtgatgg aaacggaatc
     6541 tttcagggtg ccgaaatccg ccgtttggga ggtaaagtcc gaatatccca cgatagagct
     6601 atccagcaga gtggtattcg cggtggcgct caggctcatg ccggccgaaa gaatcagggt
     6661 ggataataat ttcttcatgg tcagtatctt aataaaatga tgcaagattc aatgtatgca
     6721 cttgcgcttg aataacgaat ttggaatccg caagcaatta aaaatattaa gagttagtat
     6781 attgtattta taattcattg aaaataatga ttttttaata tctctggtcc ttttgtcaag
     6841 atgacggggc aatctttgtt attcattggt ttcatgattg atttggcctc tttttcatta
     6901 cttgacggat tccaaatccg attggggaat tccaaattcg ctacaagttg ccatccaaaa
     6961 ggaataataa atatgaagaa aacactgaca tttttaatcg cgatgggaag ctttgctgtt
     7021 tcctcggagg cagcgaccgt ttttaattat tacactcccg gtacggataa ttacaatagt
     7081 accatccatg ggttttatct tggcctgggg tcttcttccc tggctccttc cgattcctct
     7141 tctccctcct ccctgtccgg agagatcaga ctggacagtt ttacgctgcg cggagccgcc
     7201 aacaatttgg gcgctaatgt cacttacggc ttcctggtgc tgaatggctc cgacaattcg
     7261 gtcatcggct ggagcaccaa tacgggaact actgcagcag ggattaatct gacgttcagt
     7321 ttttcttccc tggatggttc tcccctgctt cttgacgcgg cattgacata ccgtttcctg
     7381 gccgtgagcc agtccgtgat ggacttgatg caggatacgt ctaaaacgta tttatatgct
     7441 gcggggggaa cagccgcccc tactgctaac acggaaggag ataccgtaac gatcagcggc
     7501 ggattgactg ctcccggcat ccgcggccat tatgacgccg agggagcgcc tggtgattct
     7561 gtcgttatta cgggagccaa cggaaccaat actttcagct tattatcccc gattttcacg
     7621 gaaatccgag gggaaatggt gccggaacca gccacggttt ccctgggcct gctgggactg
     7681 gccgcgctga tgatgcgccg cctcagggct tgagcttcct gatggcgaaa aatcggcgga
     7741 tgagagctgt tcttgcggaa cagctcttgt tttttatatc cagagaggaa gaattgctta
     7801 tccgtatgcg ggattcatgc cctccggaag gtacggaatt tccgggggca gggggccgta
     7861 tccggttttt tcggcatggc ggcaatttgc tggaaacgtt tttgagacgc agtaccggaa
     7921 agctttttct ttaccgggaa atgccgtcaa attcggcagc gcgcttttcg tccatatggt
     7981 acacggcagc tttcacatag tggcctttca ggccggatag ggaacccctt tgcagctcac
     8041 agacctggag ggccgccgca tacatattat tcgccgtcct attccccggc gctggtattt
     8101 cggaagaacg gcaatgggcc ccatgcccag cacttcatat tcttttccat cgtctgccct
     8161 gatgacggac gttgcatcaa cgatgtttcc cgacgatgcg gctgccgtgg acggcgactg
     8221 catccagctc cgggatgaag gacggactga cgcgcatgat atggagcagg taatgttcat
     8281 ggcagccggg gacgaaatag ttccagaacg cttctctcgt gacatgttcc gtttcggcat
     8341 ggtctgagga ttgttccgtt cttaatgcaa tggtcatgaa aggttgttct ttacggctcc
     8401 cccttggaga aattccagag gcggtgcatc gtcataatgt ccggaatgtt catggggcgc
     8461 accacgcgga acccgatcat gcctccgtcc gtcaggtacc agatgctttt agggttttga
     8521 ggatcctgac ggttccaggc gggggtgctg gcgcggcgcg cagcgcttct caggctgtcc
     8581 gggtcgtctt cccacgaacc gccgcgaacg atgtgagggg cgctggggat gatgaccaag
     8641 gggtctttcg cgggcaagcc gctccgtttg ccgtaggcat ccggaacgta agagtccaaa
     8701 acccattccg ccacatttcc gtgcatgtcc cggagtcccc acttatttgg ttttttagag
     8761 cctgttttct ggtagcggtc attggagttg ttccagtacc aggcgtactg gtccagagag
     8821 gcttccccgt ttccgtaaga ataggcgccg ggggagccgg cccggcaggc gtattcccat
     8881 tccgcctccg tgggcaggcg gtagtaatgc ccggtctggg cgctcagcca ttcgcagaat
     8941 ttgctggcgg cgtggtggga catggagatg gcgggcagac cgtgttcata gccgtggccc
     9001 atgcccaggt tcatggcggt gtagggggcg gtaggctgcg taacggagtc ccacagttcg
     9061 tcatccggct gttcctccag aagctggccg tccttggcgc gcggacgccc gttttccatg
     9121 aaggccgtat aaagttccca ggggatttcc gtttccgaga tccagaaggg ggagatgctc
     9181 actttatgct gcggaccttc gtccggtttc cggtgcggct cttccgcggg actccccatg
     9241 aggaacgttc ctcccggtat ggcgaccatg cgcagggaag cttccgccac gggaaccgtt
     9301 tccgtgtagg attcaaaacg tgccggattt ccggaagctt caatgagctg atggatttgg
     9361 cgcgttgtgc cgaccagctc ccgggacggc aggtcatccg gaatgggaag ggcaggaccg
     9421 gcagcgcggt ccagttcccg tttttgcagc gcggatcggc tttctcccca ctggcgtgcg
     9481 ctggtaatgc gcgcggcatc ttccgtggcc gggcgggggg aattattttc ttcccggcac
     9541 ccggccagca gggcgcttcc tcccagaaag caggaaacaa ggaaaatgcc gcgcatggaa
     9601 tggagaaaac cggaatgccc tacatcgtca tgcctccgtc gcaggcaatg acctgcccgg
     9661 tgatgtaacg ggcatcgtca gaggcaagga aggccgtcag ggcggcgata tcttccacgg
     9721 aaccttgttc tttcaaaggt attttcttaa cgatttcttc cttgagattg tcgggaatgg
     9781 cattggacat ttccgtggag atgaagccgg gagcaatggc gttgcacgtg actttgcgcg
     9841 gagcgaattc ctgagccagt gatttggtga aaccgatgag gcccgccttg gaagcggcgt
     9901 aattggcctg accgatgttg ccgacgagac cgatgacgga gctcatgttg atgatgcgcc
     9961 cggccgggga tttcatgaga acgcgctgga gggccttgac cgtattgaac gcgcttttca
    10021 ggttggtgtc cagaacggca tcccagtctt cctctttcat gcggagcatc agggagtccc
    10081 gcgtgatgcc ggcgttgttc accaggatgt caatctgcgg gaagtctttc aaaatggcgg
    10141 ccatggtttc ctgaacggcc gcgtaatccg ctacgtcgca ggggtaggcc ttgcaggaat
    10201 ccggaaattc cttgttgatt tcttctgcgg cccccccgca gctggatgga ctgcggctga
    10261 tcaggatgac cctggctcct tccgaagcga agcggcgcgc gacggcattg ccgattccgc
    10321 ggcccgcgcc ggtaacgatg gctgttttac ctgctaactt ttgcatgctg cccacagtaa
    10381 acccgttttt cacggttccg gcaagcttga aatggacttg gccgcgcagg aacccatacg
    10441 gggaaggggc gtgccgggaa tgaaaaaaga ggggggagaa acggggcggg gggctactgt
    10501 ccggcctctt cattttcccg gagtgcaccg gggggcgccc cgtcttcatc cggttctacc
    10561 aggtcgctga attcatccga attttccaaa atgtccttta aggcggcgga accgtaatag
    10621 cgggcctcaa acaggcgttt gccttcctgc ctgcagcggt tgtccagcat ttccattcgt
    10681 ttttccattt tttctatcaa ggcgtcttct ttctcctttt ccgcatcgtt caatttatcc
    10741 tgaagctgga ggaaatgccg gatgtccttc tgaatgtcct gcagcgtttt gacggcgttg
    10801 tccacgcttt ccttgtcctg aacgcctgcc aacgtctgct ggatattgat ggcaaaggaa
    10861 aaggcctggt tgatcaggga ttccgcggaa ggaatttttt ccgccggagc cgctgctgcg
    10921 ggggaagccg ttccggcggc cgtttcacca aatgcaagag aggctccgga cagaagcgca
    10981 gaatataaga gaggaacaag aaaagccttc atcctgttct tttaaggcag gatgaaatcc
    11041 acggcaagga aaaaggggaa actgaaaaaa gagccttatt ccgccgtgat gccgcctttt
    11101 tcatcgtcca gaatgcctga cttttccaga tagtagtcat atccacctgc gtaggcggtg
    11161 atggtccccc ggttcacatg cagggttttt tgtgccaggg aacggatgaa gtgcacatcg
    11221 tgggagatga agaccagtgt tccttcataa tgcttcagag cctgcaccag ggcttctacg
    11281 gacaaaaggt ccaggtgggt ggtcggctcg tccatcagca ggaggttggg cggatccacc
    11341 aggaatttga ccaggctgag ccgcgatttt tccccgccgg aaagaacgct gacgcgtttt
    11401 tccacatcca gcctccggaa caggaaggaa cccaggatgg aacgcgcttc ttcctcccgg
    11461 atttcagcgc tgcatttcat gatttcctcc agcacggtat tttccggatt caggttttcc
    11521 gttcgcgcct gggagaagta gccgatgcgc gtcgtggtac cgggagtgcg ttgtccggag
    11581 tcaatgggga tgatgcccgc caggattttg agaagagtgg atttgcccgc gccgttcggg
    11641 cctacaagaa cagtgcgctc cccgcgttct accagcaggt ccaggttttc ataaaccctg
    11701 cggtcgccat aggattggca gactttttcc agctcaatga ctttctgggt gctgcgcgga
    11761 ggctggggga agttgaattt aaatactttc ctgcgggcta ccggtttttg aatgattttc
    11821 atcttttcca gctgcttgat gcggctctgg acttgcccgg ctttggaatt gatggagcgg
    11881 aaacggtcaa taaattcctg aatgtgcgct atttccttct gctggttgcg gtaggccgcc
    11941 tgaagctgct cgaagcgcac gtccttttgt tggaggaagt ccgagtaatt gccgcggtat
    12001 tccaccagtt cttcgttgtc gatgtcgtac acgctttcca ccagctcatc catgaaatcc
    12061 cggtcgtggg aaatcatcag gatggctccg gggtagtttt tcaggtatcg ctggagccac
    12121 agcagggaca ggaggtccag gtggttggta ggttcgtcca gcatcaggag gtccggctcc
    12181 aggacaagga gcttggccag gtacgcgcgc atgatccagc cgccggacat ttcccgggcg
    12241 gggcggtgga agtcgctttc ccgaaaggcc agccctttga gaattttttt ggctttgggc
    12301 tccagctggt aaccgttggc ggcgttgaag gtgtcaatgg cttccgcgta ttccggcgta
    12361 tccgttttgt tggcgttttc cgccgtccgg atggtgtgga tggcctgttc catttccggc
    12421 gtgatgccca gggcgatttc cagaacggtt tcatccttcg gttcgctggc ttcctgggga
    12481 agatagccca cgatggcgta ttcatccatg ctgatggagc cttcgtccgg cgtgtcttct
    12541 cccagaatca tgcggaacag ggtggatttg cctgctccgt tggggccaac cagagccacc
    12601 cgttcccccc agttaatggt catttccgtt tccctgaaca aggtccgtcc ggcgtgggat
    12661 tttgtgagat ttttgatcgt cagcatggtg aagagaggat gtattctacc gggatggaaa
    12721 ggggaaggca agagccgtca gggcggaggc aggcattttt gaaagcttta ctggattttt
    12781 acgcgtagtc tgctagcctt ggcgcgccat gccgaccacg cagacattca ggcttttgct
    12841 tgctgccgcc cttttgtgcg gatggagttc ctgctgtact cctccggcgg aggattatat
    12901 acaacaacct tacgtgcagc agcaaatgtc cgggctggct aatgccttcc tggcgctgct
    12961 gccgccggat caggcctctc ttcccgctgc cggagcggag gccaggtggc tggcggacac
    13021 ggccgtggtc cagtccgcag cgattgcccg ggacaacagg actgtgctgt ttggctggct
    13081 gaacaatatt ctggtcaatt ccaacctgcg cgacaggggg ctgtgctggc aggtccagca
    13141 ggatttgtac cgggacctgc gccgccgccc cgtgaagtat ttccgcatag ggctgacgat
    13201 tcgagaccgt ggaacgggca gggagcacag ttgcgtgtat gtcaatgccg tggggaaggg
    13261 attgcagggc tccattgttc tggatgcctg gaagaactgc gggcatctgg tgacgctgac
    13321 ccagaaggac cgggaaggcg gcaaatggga ggaggactgg cgggaaccat ttgtttccaa
    13381 ggcctttccg gagggccatt cctacggcat ggaacatcac ctggtctggc ccgggtgggc
    13441 caggaaacgc cccatgctgg ttcagcggat atttcagtcc gatcagcaga atgaggcgaa
    13501 ggcggccgct gaataaaggg gaagcctgat ccggcaggaa ccggcacacg gtgctgcgcc
    13561 gcggcggttt gcggtatccg ccgtttttaa ggaaaatccc ggcgaatcgg caaatggcgg
    13621 agggaatccg gactcagggc aaataaaaac gcactcagtg cgtacaccga gtgcggatta
    13681 attggataat ttgctagtgt tgcagggcaa aaccccgctg caaacttact tgcccttggc
    13741 ctgcacaacc ggagcgggag caggagcggt ggtttgctgt tgctgctgct gctgggagca
    13801 agaagcgacc aggcaagcgg cgccggcgat ggcgaggata gcgatgttct tcataattcg
    13861 aattaaatac agtgtttgtt aactactgga acctccgcat ccacggaggt ttgctggcac
    13921 caatgtaaat ggtggcaagt agaaatcaag agattttctt gttccatgtc acgg
//
