LOCUS       c00164_gnlPro..         5974 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|HEOKPEHK_164.
ACCESSION   c00164_gnlPro..
VERSION     c00164_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-05 02:45:20
            Original ID  :: gnl|Prokka|HEOKPEHK_164
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 5974
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..5974
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[1019:5258]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      1020..5258
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..5974
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..5974
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             complement(2..220)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg164_1"
                     /sec_met_domain="IlvN (E-value: 6.4e-17, bitscore: 50.3,
                     seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAQLNFGGVIENVMTREEFPLEKAREILKDETIAVIGYGVQGPGQ
                     ACNLRDNGFNVIVGQRPGKTYEKAVADG"
     CDS             complement(271..1023)
                     /locus_tag="ctg164_2"
                     /transl_table=11
                     /translation="MMSENNKIGTYKFVAEPFHVDFTGRLTMGVLGNHLLNCAGFHASD
                     RGFGIATLNEDNYTWVLSRLAVELDEMPYQYEDFSIQTWVENVYRLFTDRNFAIIDKEG
                     KKIGYARSVWAMISMNTRKPADLLALHSGSIVDYVCDEPCPIEKPSRIKVASKEPVAAL
                     VAKYSDIDINGHVNSIRYIEHILDLFPIEMYKEKRIRRFEMAYVAESYYGDELTLFMDD
                     AGEGVYDVEVKKNGSEVVCRSKVIFTEK"
     CDS             complement(1020..1580)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg164_3"
                     /sec_met_domain="ALS_ss_C (E-value: 3.6e-20, bitscore:
                     60.8, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKKLYTIIVHSENFAGLLNQVTAVFTRRQINIESLNVSASSIKG
                     VHKYTITAWTDKDTIEKVTKQITKKIDVLQAHYFTDDEIYQHEIALYKITTPTLEEKPE
                     VSKVIRKYNARIVEVNAVFAIVEKNGMSEEITNLYEELRQLDCVLQFVRSGRVAITTSC
                     FERVNEYLADREAKYRQSKHQES"
     CDS             complement(1613..3364)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg164_4"
                     /sec_met_domain="TPP_enzyme_C (E-value: 5.1e-48, bitscore:
                     151.4, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MADNNKKSNFSSLSQGEGRGEALITGAEALMRSLEHQGVKTIFGY
                     PGGSIMPVFDALYDHRKELNHILVRHEQGATHAAQGFARVSGEVGVCLVTSGPGATNTI
                     TGIADAMIDSTPIVVIAGQVGTNFLGTDAFQEVDLVGITQPITKWSYQIRRAEDVAWAV
                     ARAFYVAKSGRPGPVVLDFAKNAQVEKTEYAPTKVDYVRSYLPVPEMEPEAIRKAAELI
                     NGAKRPLVLVGQGVELGEAQQELRAFIEKAGMPAGCTLLGLSALPTNHPLNKGMLGMHG
                     NLGPNINTNKCDVLIAVGMRFDDRVTGKLETYAKQAKIIHFDIDPAEIDKNVKTDVAVL
                     GDCKETLAAVTQLLEPANHQEWIDSFRQYEEVEEEKVIRPELHPAGKALSMGEVVRAVS
                     EATHNEAILVTDVGQNQMMSARYFKYSKERSIVTSGGLGTMGFGLPAAIGATFGRPDRT
                     VCVFMGDGGLQMNLQELGTIMEQKAPVKMILLNNNFLGNVRQWQAMFFNRRYSFTPMMN
                     PDYMKIASAYDIPARRVMTREELAKAIDEMIATDGPFLLEACVEEEGNVMPMTPPGGSV
                     NQMLLEC"
     CDS             complement(3456..5258)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ILVD_EDD"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg164_5"
                     /sec_met_domain="ILVD_EDD (E-value: 3.3e-219, bitscore:
                     717.3, seeds: 918, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKHQLRSSFSTQGRRMAGARALWTANGMKKEQMGKPIIAIVNSFT
                     QFVPGHVHLHEIGQFVKEEIEKLGCFAAEFNTIAIDDGIAMGHDGMLYSLPSRDIIADS
                     VEYMVNAHKADAMVCISNCDKITPGMLMAAMRLNIPTVFVSGGPMEAGEWNGQHLDLID
                     AMIKSADESVGDKEVAQIEQHACPTCGCCSGMFTANSMNCLNEAIGLALPGNGTIVATH
                     ENRKRLFEDAAKLIVANAFRYYEEGDESVLPRSIATREAFLNAMTLDIAMGGSTNTVLH
                     LLAVAHEAGADFKMDDIDMLSRKTPCLCKVAPNTQKYHVQDVNRAGGIIAIMDELAKGG
                     LVDTNVRRVDGMTLAEAIDRYSITSSNVCKEAIKKYSSAAAGKFNLVLGSQNASYKELD
                     TDRATGCIRDLEHAYSKDGGLAVLKGNIAQDGCVVKTAGVDESIWKFTGPAKVFDSQDA
                     ACDGILGGKVVSGDVVVITHEGPKGGPGMQEMLYPTSYIKSRHLGKECALITDGRFSGG
                     TSGLSIGHVSPEAAAGGNIGKIKDGDIIEIDIPNRSINVKLTDEELAARPMTPVTRNRE
                     VSKALKAYASMVSSADKGAVRLID"
     CDS             5749..5973
                     /locus_tag="ctg164_6"
                     /transl_table=11
                     /translation="METVENKYITVAYKLYSIENGEKDFEEEAPVEHPFQFISGLGMTL
                     EPFEAQIKDLQIGDKFDFTIPASEAYGEYD"
ORIGIN
        1 atccgtcagc cacagccttt tcgtatgtct tacccggacg ttgtcctaca atcacattga
       61 aaccgttatc acgcaagttg caagcctggc ccgggccttg tacgccataa ccgattactg
      121 caattgtttc atctttcaaa atctcacgtg ctttttccaa aggaaattct tcgcgggtca
      181 ttacattctc aataacaccg ccaaaattca attgtgccat tttttgtttt aatttttatt
      241 tgtggcttac gccaacgttg ataaatttat ttatttctct gtaaatatca ctttagagcg
      301 acagaccact tcgctgccat tctttttcac ctccacatcg taaacgccct caccggcatc
      361 atccatgaac aaagtcaact catccccata atagctttcg gctacatatg ccatttcaaa
      421 acgacggatg cgcttctcct tatacatctc tatcgggaac aaatcaagga tatgctcgat
      481 gtaacggatg ctgttcacat gcccgttaat gtcaatatca ctgtatttgg ctaccaaagc
      541 agcaaccggt tcctttgagg ccacctttat ccgcgaaggt ttttctatcg ggcaaggctc
      601 atcgcaaaca taatctacaa tgctgccact atgaagagcc agcaaatctg ccggcttacg
      661 ggtattcatg ctaatcatcg cccaaacgga acgtgcatac ccaatcttct taccctcctt
      721 atcgatgata gcgaaattac ggtctgtaaa aaggcgatag acattctcca cccaagtctg
      781 aatggagaaa tcttcgtact gataaggcat ttcatccagt tcgacagcca gacgggacaa
      841 tacccaagta taattgtcct cgtttagagt cgcgatgcca aaaccgcggt cgctggcatg
      901 gaaacccgca caattcaaca aatggttgcc caatactccc attgtcagcc gtccggtaaa
      961 gtcgacatga aacggttcgg caacaaactt gtaggtacct attttattgt tctcgctcat
     1021 catgattcct ggtgtttact ttgacgatat tttgcttcac ggtccgccag atattcattg
     1081 acacgctcaa agcagctggt cgtaatggct acgcgacccg aacggacgaa ctgaagtacg
     1141 caatccaact ggcgcaactc ctcataaaga ttggttattt cctcactcat gccattcttc
     1201 tcaacaatgg caaatacagc attcacctcc acaatacggg cattgtactt acggattact
     1261 ttggacacct ccggtttttc ttccagcgta ggggtcgtta ttttataaag ggcaatctcg
     1321 tgctgataga tttcatcatc cgtgaaataa tgggcttgca gcacatctat tttcttggta
     1381 atctgcttgg tcaccttttc aatggtatcc ttatccgtcc aagcggtaat ggtatattta
     1441 tgtaccccct tgatggagga ggccgataca ttcaaactct cgatgtttat ctgccggcgg
     1501 gtaaacacag ccgtcacctg attcagcaaa ccggcaaagt tttccgaatg aacaatgatt
     1561 gtatatagtt ttttatccat agatagagta aattctttaa tttcgcatga cttcagcatt
     1621 ccaacaacat ctgattgacc gaaccgcccg gaggtgtcat cggcattaca tttccttctt
     1681 cctccacaca agcttcgagc aggaacggtc cgtcagtcgc tatcatctcg tcaatcgctt
     1741 ttgccagctc ctcgcgggtc attaccctgc gtgcaggaat atcatatgcc gaagcaatct
     1801 tcatataatc cggattcatc atcggagtaa acgaataacg acgattgaag aacatcgcct
     1861 gccattgacg aacattgccc aggaagttat tgttcaacag aatcatcttc accggagcct
     1921 tttgttccat gatggtaccc agttcctgca ggttcatctg caagccgccg tctcccatga
     1981 atacgcatac cgtgcggtcc ggacgtccaa aagtggcacc gatagctgcc ggaaggccga
     2041 agcccatagt acccagacca ccggaagtaa caatgctacg ttccttgctg tatttgaaat
     2101 aacgggcgga catcatctga ttctggccga catcagtcac caatatcgcc tcgttatggg
     2161 tagcctcact cacagcacgc accacctcac ccatgcttag cgcttttcct gccggatgta
     2221 attccggacg gattaccttt tcctcttcca cttcctcgta ttgccggaaa ctgtcaatcc
     2281 attcctgatg gttggcgggt tccagcaatt gggtaacggc agccagtgtc tctttgcaat
     2341 ctcccaggac agcaacatca gtctttacat tcttatctat ttcggcaggg tcaatatcaa
     2401 agtggataat cttcgcctgc ttggcatatg tttccaattt acccgtcaca cggtcatcaa
     2461 agcgcatgcc tacggcgata aggacatcac atttattggt attgatattg ggccccaggt
     2521 taccgtgcat accaagcatt cctttgttca acggatggtt cgtaggtaat gcggaaagtc
     2581 ccaataaagt gcatccggca ggcattccgg ctttctcaat gaaagcacga agctcttgct
     2641 gggcttctcc cagctccacg ccttgtccaa ccagcaccaa aggccgtttc gcaccattta
     2701 ttaattcagc agccttccgt atggcctccg gctccatttc gggaacggga agatagctac
     2761 ggacatagtc caccttagta ggcgcatatt ctgttttctc cacttgggcg tttttagcaa
     2821 aatccagcac gaccggtccc ggacgtccgc tctttgccac atagaaagca cgtgccactg
     2881 cccaggccac atcttctgca cgacgaatct ggtaactcca tttcgtgata ggctgagtaa
     2941 tgcctaccaa gtccacttcc tgaaatgcat ccgtacccaa gaagttcgtc cctacctggc
     3001 cggcaatgac aacgataggc gtactgtcaa tcatggcatc tgcaatgccc gtgatagtat
     3061 tggtagcacc cggtccactg gtaaccagac aaacgccaac ctcgcctgat acacgtgcaa
     3121 agccttgtgc cgcatgggtt gctccttgtt catgacgaac caagatgtgg ttcaattcct
     3181 tccgatggtc gtataaggca tcgaataccg gcatgatgct ccctcccgga taaccgaaaa
     3241 tagtctttac tccctgatgc tccagagagc gcatcaatgc ttctgcgcct gttattagag
     3301 cctcaccccg accctctcct tgggagaggg aggaaaagtt actcttttta ttattatcag
     3361 ccatacttta tctattcatt atatttaaaa gctcaatagt agcttgaaaa atttgtttca
     3421 ttctctcctc ccctcgcttt cggaaagggg ggcttttaat caatcagcct cacagcccct
     3481 ttgtcagcgg aactcaccat actggcatat gctttcaatg ctttggagac ttcacggttg
     3541 cgggttaccg gagtcatagg gcgtgctgca agctcttcat ccgtcaactt cacattgata
     3601 gaacggttcg gtatatcaat ttcgataatg tccccatcct taatcttgcc gatattacca
     3661 ccggcagccg cttcgggaga aacatgtccg atacttagtc cggaagtacc gccactaaaa
     3721 cgcccgtcgg taatcaatgc acactcctta cccagatggc gggatttgat ataagaagta
     3781 ggataaagca tctcttgcat acccggtcca cctttcggcc cttcgtgagt gatgacgacg
     3841 acgtctccac tgaccacctt tccacccaga ataccgtcac aagccgcatc ttgtgagtcg
     3901 aagactttcg ctggccccgt aaatttccag atactctcgt ctacaccggc agtcttgaca
     3961 acgcaaccgt cctgagctat atttcccttc aaaaccgcca gaccgccatc cttgctgtat
     4021 gcatgttcca aatcacggat acaaccagtc gcacggtccg tatcgagttc cttataagac
     4081 gcattttgtg agccgagtac cagattgaac tttccggctg ccgcactgga gtatttcttg
     4141 attgcctctt tacatacatt agagctggta atactatacc ggtcgattgc ctctgccaac
     4201 gtcattccat ccacacggcg gacattcgta tcgaccaatc cgcccttggc aagctcatcc
     4261 atgatggcaa tgatgccacc ggcacggtta acgtcttgta catgatactt ttgggtattg
     4321 ggagctacct tgcataagca gggggtcttg cgagagagca tgtcaatgtc gtccatctta
     4381 aaatccgctc cggcttcgtg agccacagcc aacaaatgaa gtactgtatt agtggaaccg
     4441 cccatcgcaa tatccagcgt catggcattc aaaaatgcct cgcgagtagc aatactgcgc
     4501 gggagtacac tctcatcccc ttcttcataa tatctaaagg cattcgctac aatcaactta
     4561 gctgcatcct caaacagtct cttgcgattt tcgtgagtgg ctacaatcgt gccgttaccg
     4621 ggcagtgcca atccaatcgc ttcattcagg caattcatgg aattagcggt aaacatgcct
     4681 gagcagcatc cgcaagtggg gcaggcatgt tgctcaatct gtgccacctc tttatcgccc
     4741 acactttcat cagcagattt aatcatagca tcaatcaaat ccaaatgttg tccgttccat
     4801 tccccggctt ccatcggacc gcctgaaaca aacacagtcg gtatattcag cctcatagcc
     4861 gccatcaaca tccccggagt aatcttgtca cagttactga tgcaaaccat agcatccgcc
     4921 ttatgggcat ttaccatata ctccacacta tcggcaatga tatctcttga aggcagggaa
     4981 taaagcatac cgtcgtgtcc catagcgata ccgtcgtcaa tggcaatcgt attgaactcc
     5041 gcagcaaaac accccagctt ttcaatctct tcctttacaa actggcctat ttcgtgcagg
     5101 tgtacatgtc cggggacgaa ttgtgtaaat gaattgacta tagcgataat gggcttaccc
     5161 atctgttcct tcttcatacc attcgccgtc cacaatgcac gggctcccgc catgcggcga
     5221 ccttgtgtgc tgaacgagct gcgtaactga tgcttcattt tcaaatctcc ttttaatgaa
     5281 aaagcctctc ccactatagt gagaaaggct taataaatta tcttctaacg tacgaataca
     5341 tacataacct ttctcacgct cttgatgcca ccaccacgac gcgaataata tgcaggactg
     5401 ccaggttaat agatgtatgt aaattcataa cttaattctt cttttttgtt tcaaacgtgc
     5461 tgcaaaggta agggcttttt tataatctcc aaacaaattg aagaaaaaaa taagataaat
     5521 atgaataatc gtaagaaaaa atcgccctaa aatcctattt tatcacttaa cagttctaaa
     5581 tagaaccatt cagacagcca atgtaaatgt attgccaatc attgaaacca tttaataatc
     5641 tgaaaattac caaaggctct ctacatcccg aaacaaataa ttcgtatctt tgtctcttca
     5701 aatactcaaa aaaacagtat ttactaatta aataaagata gaaaattaat ggaaacagta
     5761 gaaaacaagt acatcaccgt agcatataag ctgtactcaa tcgaaaacgg agaaaaagat
     5821 ttcgaagaag aagcacccgt agagcatcct ttccagttta tctcaggtct gggaatgaca
     5881 ctcgaacctt ttgaagccca gataaaagac ttgcagatag gcgataaatt cgactttacc
     5941 attccggcat cagaagctta tggtgaatat gacg
//
