LOCUS       gnlProkkaAINFCCGJ_120  10629 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|AINFCCGJ_120.
ACCESSION   gnlProkkaAINFCCGJ_120
VERSION     gnlProkkaAINFCCGJ_120
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-12-01 19:09:44
            Original ID  :: gnl|Prokka|AINFCCGJ_120
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 10629
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             complement(1..414)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     arylpolyene: APE_KS2"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg120_1"
                     /sec_met_domain="APE_KS2 (E-value: 4.7e-28, bitscore: 87.9,
                     seeds: 16, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRKIYVTGLGVISGIGKGVEENLDSLKAGKHGMGKITLFPTALDV
                     PVSEVKQSNEELKKLLSLPSGKTYSRTALLGLWAAQEAARDAELDFTSPRIGLISSTSI
                     GGMDASERFYASFREDNRKGRLRDIISHDCGSST"
     protocluster    1..10629
                     /aStool="rule-based-clusters"
                     /category="PKS"
                     /contig_edge="True"
                     /core_location="[0:6544]"
                     /cutoff="20000"
                     /detection_rule="(APE_KS1 or APE_KS2)"
                     /neighbourhood="20000"
                     /product="arylpolyene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      1..6544
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(APE_KS1 or APE_KS2)"
                     /neighbourhood="20000"
                     /product="arylpolyene"
                     /protocluster_number="1"
     cand_cluster    1..10629
                     /SMILES=""
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(APE_KS1 or APE_KS2)"
                     /kind="single"
                     /product="arylpolyene"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10629
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="arylpolyene"
                     /region_number="1"
                     /rules="(APE_KS1 or APE_KS2)"
                     /tool="antismash"
     CDS             complement(411..668)
                     /NRPS_PKS="Domain: PP-binding (16-79). E-value: 1e-10.
                     Score: 33.9. Matches aSDomain:
                     nrpspksdomains_ctg120_2_PP-binding.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg120_2"
                     /sec_met_domain="PP-binding (E-value: 2.2e-11, bitscore:
                     33.9, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEELIDKLKVELIEALNLEEITPEDIDSEAPLFGDDGLGLDSIDA
                     LEIILILERNYGIKIENPAKGKEIFYSVRTLADYITAHQK"
     aSDomain        complement(432..620)
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg120_2_PP-binding.1"
                     /evalue="1.00E-10"
                     /label="ctg120_2_PP-binding.1"
                     /locus_tag="ctg120_2"
                     /protein_end="79"
                     /protein_start="16"
                     /score="33.9"
                     /tool="antismash"
                     /translation="NLEEITPEDIDSEAPLFGDDGLGLDSIDALEIILILERNYGIKIE
                     NPAKGKEIFYSVRTLADY"
     CDS             complement(674..2404)
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (127-378). E-value:
                     1.9e-26. Score: 84.7. Matches aSDomain:
                     nrpspksdomains_ctg120_3_PKS_KS.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     arylpolyene: APE_KS2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022:Beta-ketoacyl synthase (Score: 171.9; E-value:
                     3.8e-52)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg120_3"
                     /sec_met_domain="APE_KS2 (E-value: 7.4e-128, bitscore:
                     416.4, seeds: 16, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEHHLTTYITHDTLISALGFGTQENLEAIRSYHSGITLQTDKRIA
                     DTPLLAATLSQERLQQQAEAIGVSGYPRMEQLFILTINELIRQSGQTLEDKTCGLILST
                     TKGNIDLLARHTEHPDEAVFLWKMAENIAGYFHAEERVHVISNACISGVSALIAGKRMI
                     ENGIYRRVIVAGGDLLSHFITSGFGSFRSLSSRPCRPYDSSRDGLNLGEACGAVLLSSE
                     GTEEHVILSGGAVSNDANHISGPSRTGDGLYFAIRQAMQEAGTAPQDISFVNAHGTATL
                     YNDEMESKALTLAHLEQVPVHSLKPYFGHTLGASGIIESIVCMHELKQGILFGTPGYET
                     PGIPMPIPVYATHRSIPMKHCVKTASGFGGCNAAIVLSLPEYTPFKDEDNTLPEIRCTR
                     EVRIENSSVFINNELIFHSEEPDFGTFIRDTYKKTCGNNLKFYKMDDLCKLGYVAAEYL
                     LEGKTFAPLEMGMLLANAASSLHTDIRHQQLIDREGDQAASPAVFVYTLPNVVSGEICI
                     RHKIQGENTFFITEAYQPEKLERYARIVMQKGKLNYCIIGWCELWKNTYKAVFKLIEKQ
                     "
     aSDomain        complement(1271..2023)
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg120_3_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="1.90E-26"
                     /label="ctg120_3_PKS_KS.1"
                     /locus_tag="ctg120_3"
                     /protein_end="378"
                     /protein_start="127"
                     /score="84.7"
                     /tool="antismash"
                     /translation="MAENIAGYFHAEERVHVISNACISGVSALIAGKRMIENGIYRRVI
                     VAGGDLLSHFITSGFGSFRSLSSRPCRPYDSSRDGLNLGEACGAVLLSSEGTEEHVILS
                     GGAVSNDANHISGPSRTGDGLYFAIRQAMQEAGTAPQDISFVNAHGTATLYNDEMESKA
                     LTLAHLEQVPVHSLKPYFGHTLGASGIIESIVCMHELKQGILFGTPGYETPGIPMPIPV
                     YATHRSIPMKHCVKTASGFGGCNAAIVLS"
     CDS             complement(2389..2832)
                     /locus_tag="ctg120_4"
                     /transl_table=11
                     /translation="MKRKTSPHQAALTDRTTIKVRFSEIDSMQIVWHGEYVRYFEDGRE
                     AFGKRYGLDYMSIYREGYVVPIVDLTCQFKQPLSFGEEAIVETRYIHSDAAKILFEYTI
                     YRASDQNIVATGTTTQVFLNTNRELELVNPAFYIEWKKKWNII"
     CDS             complement(2829..3266)
                     /locus_tag="ctg120_5"
                     /transl_table=11
                     /translation="MSSKEIICQGEELFRLIPQRPPMVMIDRFYGIEENTSWSGLTVTP
                     DNLFCRDGVLQETGIIEHIAQSAAARVGYIYMLRKEPVPLGFIGSVEKMKLFRLPSAGA
                     ELYTGITIVQEVFDITLITAEVKENDELLAECRMKIYLKKE"
     CDS             complement(3263..4144)
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1042:O-methyltransferase (Score: 89.2; E-value:
                     4.9e-27)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg120_6"
                     /transl_table=11
                     /translation="MMHKRYTKEQCTAAEAQRLAQEIAFGPVVFQVSRLMLKFGIFQLL
                     SGKREGYTLQEISGQTGLTRYAAXXXXFGEWPTIYEGLSQLPEQVQKSWFGFDHFYSDQ
                     SFGKALEIVFSHHPKRLLDIGGNTGRWATQCVQYNKEVEVTIVDLPQQLEMMRKQTAGL
                     SGSERIHGHGANLLDRDVPFPTGFDAVWMSQFLDCFSEEEVISILTRVAQSIGKDSKVY
                     IMETLWDRQRYETASYCLTQISLYFTAMANGNSKMFHSDDLIRCIENAGLEVEEIQDNI
                     GLGHSILQCRLK"
     CDS             complement(4158..5042)
                     /locus_tag="ctg120_7"
                     /transl_table=11
                     /translation="MSETWKGKTRGGIFGYMFFIYMIRCLGITAAYGFLALVVLYFIPF
                     APKATGNTWSYARNRLKYGRLKSVALLLKNYYRLGQILIDKVAIGNGMTGKYHFKFENY
                     QAFLDVLNGNTGVIMIGAHVGNWEIGAPFFDEYGKKINIVMFDAEHERIKEILEKNAST
                     RDYKIIPVNEDSLTHVFRITEALDRREYVCFQGDRYLNKEKLLTTSFMGKEAKFPMGPF
                     LLASKLKVPVVFYFAMREAQRTYRFHFFIAETVVRTKEKRAEQALLEQYTQTLEKIVRQ
                     YPEQWFNYYPFWT"
     CDS             complement(5042..5293)
                     /NRPS_PKS="Domain: PP-binding (7-74). E-value: 4.3e-14.
                     Score: 44.7. Matches aSDomain:
                     nrpspksdomains_ctg120_8_PP-binding.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg120_8"
                     /sec_met_domain="PP-binding (E-value: 9.2e-15, bitscore:
                     44.7, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTNEEIIEKIRTTLAEEFEIDVEQIQPDAPLMQTLELDSLDLVDM
                     VVLIDKNFGFTVTAKDFAGIKTFQDFYNLVISHMQKED"
     aSDomain        complement(5072..5272)
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg120_8_PP-binding.1"
                     /evalue="4.30E-14"
                     /label="ctg120_8_PP-binding.1"
                     /locus_tag="ctg120_8"
                     /protein_end="74"
                     /protein_start="7"
                     /score="44.7"
                     /tool="antismash"
                     /translation="EKIRTTLAEEFEIDVEQIQPDAPLMQTLELDSLDLVDMVVLIDKN
                     FGFTVTAKDFAGIKTFQDFYNL"
     CDS             complement(5315..6544)
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (77-405). E-value:
                     1.1e-50. Score: 164.6. Matches aSDomain:
                     nrpspksdomains_ctg120_9_PKS_KS.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     arylpolyene: APE_KS1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022:Beta-ketoacyl synthase (Score: 308.5; E-value:
                     1.3e-93)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg120_9"
                     /sec_met_domain="APE_KS1 (E-value: 2.7e-171, bitscore:
                     559.4, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRRVVITGMGIYSCIGKNQDEVKDSLFQGRSGIGIDPARKEMGYF
                     SALTGLVERPDLKKLLDRKKRHSLAEQGEYAYMATLEAFRQAQIDEEFLLDHEVGILYG
                     NDSSAAPVIEAIDVIRAKKNTAMVGSGSIFQSMNSTITMNLSVIFHLKGINFTISGACA
                     SGSHAIGMAYLLIKSGLQDCILCGGAQEVNPYSVGSFDGLGAFSTREDEPEKASRPFDK
                     GRDGLVPSGGGASLVLESYESAVRRGATILAEVIGYGFSSNGDHISVPNVDGPRRSLQM
                     AINDAGIPLEEIQYINAHATSTPVGDLNEAKAIAEVFGNHRPYVTSTKSQTGHEMWMAG
                     ASEVIYSILMMNNGFIAPNLNFEEPDEASALLNIPSRRIETEFDTFLSNSFGFGGTNSS
                     LIIRKFKENN"
     aSDomain        complement(5330..6313)
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg120_9_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="1.10E-50"
                     /label="ctg120_9_PKS_KS.1"
                     /locus_tag="ctg120_9"
                     /protein_end="405"
                     /protein_start="77"
                     /score="164.6"
                     /tool="antismash"
                     /translation="MATLEAFRQAQIDEEFLLDHEVGILYGNDSSAAPVIEAIDVIRAK
                     KNTAMVGSGSIFQSMNSTITMNLSVIFHLKGINFTISGACASGSHAIGMAYLLIKSGLQ
                     DCILCGGAQEVNPYSVGSFDGLGAFSTREDEPEKASRPFDKGRDGLVPSGGGASLVLES
                     YESAVRRGATILAEVIGYGFSSNGDHISVPNVDGPRRSLQMAINDAGIPLEEIQYINAH
                     ATSTPVGDLNEAKAIAEVFGNHRPYVTSTKSQTGHEMWMAGASEVIYSILMMNNGFIAP
                     NLNFEEPDEASALLNIPSRRIETEFDTFLSNSFGFGGTNSSLIIRKF"
     CDS             complement(6552..7280)
                     /NRPS_PKS="Domain: PKS_KR (3-170). E-value: 8.5e-19. Score:
                     60.0. Matches aSDomain: nrpspksdomains_ctg120_10_PKS_KR.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     219.8; E-value: 6.5e-67)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg120_10"
                     /sec_met_domain="adh_short (E-value: 2.6e-37, bitscore:
                     118.2, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKYALVTGGSRGIGRAVCLKLAEMGYHILINYQSNDTEAEATLQQ
                     IREQGSDGELMKFDVTDAVATHAALNGWMEKHPDTYIEVLVNNAGIRRDNLMLWMEQDE
                     WSRVLDISLNGFFNVTQPLLKNMLVKRFGRIINIVSLSGIKGMPGQTNYSAAKGGMIAA
                     TKALAQEVARKHVTVNAVAPGFIRTDMTNGIDENEWKKQIPAGRFGEPGEVAALVGFLA
                     SEQASYITGEVISINGGIYT"
     aSDomain        complement(6771..7271)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg120_10_PKS_KR.1"
                     /evalue="8.50E-19"
                     /label="ctg120_10_PKS_KR.1"
                     /locus_tag="ctg120_10"
                     /protein_end="170"
                     /protein_start="3"
                     /score="60.0"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="ALVTGGSRGIGRAVCLKLAEMGYHILINYQSNDTEAEATLQQIRE
                     QGSDGELMKFDVTDAVATHAALNGWMEKHPDTYIEVLVNNAGIRRDNLMLWMEQDEWSR
                     VLDISLNGFFNVTQPLLKNMLVKRFGRIINIVSLSGIKGMPGQTNYSAAKGGMIAATKA
                     LAQE"
     CDS_motif       complement(7206..7268)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg120_10_0001"
                     /evalue="2.80E-06"
                     /label="PKSI-KR_m1"
                     /locus_tag="ctg120_10"
                     /protein_end="25"
                     /protein_start="4"
                     /score="20.0"
                     /tool="antismash"
                     /translation="LVTGGSRGIGRAVCLKLAEMG"
     CDS             complement(7277..8848)
                     /locus_tag="ctg120_11"
                     /transl_table=11
                     /translation="MRKLYKTAYHTNPMLAENKITLASLYKILFEEEPLTLSDQCMQKL
                     EESFHFLKTFSNDKIIYGINTGFGPMAQYRIEDESLSQLQYNIIRSHATGAGQPLPELY
                     VKAAMIARLYTFLQGKSGIHKELALLITEFINRGITPYVPEHGSVGASGDLVQLAHIAL
                     TLIGEGEVFYQGKKRDTASVLAENGLQPFKMHIREGLSVTNGTSVMTGIGIVNLIYARQ
                     LMHWAVGASVMMNEIAASYDDFMSEPLNEAKRHEGQQEIARMMRQWVEGSQCVRKRENE
                     LYNGKHEEKIFTHKVQPYYSLRCIPQILGPVYDELLNAEKVLINEINSACDNPIVDPDT
                     QNVYHGGNFHGDYVSFEMDKLKIAVTKLAMLAERQINYLFHDRINGILPPFVNMGVLGL
                     NYGLQASQFTATSTTAECQTLSNPMYVHSIPNNNDNQDIVSMGTNSALLAKTVIENAYQ
                     VMAILMMGIVQAVDCLEIAGRLSPRSQQVYKEIRAFFPVFREDTPKYKEIERMMVYLKK
                     GRFQEK"
     CDS             complement(9036..10517)
                     /locus_tag="ctg120_12"
                     /transl_table=11
                     /translation="MENKLTIYNTLSRQKELFVPLHAPHVGMYVCGPTVYGDAHLGHAR
                     PAITFDILFRYLTHLGYKVRYVRNITDVGHLEHDADEGEDKIAKKARLEQLEPMEVVQY
                     YLNRYHKAMEALNVLPPSIEPHASGHIIEQIELVEEILKNGYAYESEGSVYFDVAKYNK
                     DHHYGKLSGRNLDDVLNTTRELDGQSEKRNPADFALWKCAQPEHIMRWPSPWSNGFPGW
                     HCECTAMGKKYLGEHFDIHGGGMDLIFPHHECEIAQSVASQGDDMVHYWMHNNMITING
                     QKMGKSYGNFINLDEFFHGTHKLLTQAYSPMTIRFFILQAHYRSTVDFSNEALQAAEKG
                     LERLTEAVKGLERITPATQTTGIEGVKDLREKCYTAMNDDLNSPIVIAHLFDGARMINT
                     VLDKKATISAEDLEELKSVFHLFMYEILGLKEEAANNEAREEAYGKVVDMLLEQRMKAK
                     ANKDWATSDKIRDELAALGFEVKDTKDGFTWKLNK"
ORIGIN
        1 ggtactggac ccacagtcat gggagataat gtcacgtaat ctccctttcc ggttatcttc
       61 ccggaaagag gcataaaacc gctcgcttgc atccattcct ccgatggaag tggaagaaat
      121 gagcccgata cggggagaag tgaaatcgag ttccgcatca cgggccgctt cttgggctgc
      181 ccacaagccc agcaaggctg tacgtgaata cgtcttgccg gatggaaggg acaggagttt
      241 ctttaattct tcattgctct gttttacttc ggacacgggt acgtcaagtg cggtggggaa
      301 aagggtgatt ttccccatac cgtgttttcc ggcttttaag gaatccaggt tttcttccac
      361 tcctttccct atgcccgaaa tcactcccag accggtgaca tagatcttcc tcatttctga
      421 tgggcggtga tgtagtctgc cagggtacgt accgaataga atatttcctt gcctttggca
      481 ggattctcta tcttgattcc ataattcctt tccagaatca ggataatctc taatgcgtca
      541 atcgagtcaa ggcccagacc gtcatctccg aataaaggtg cttcactgtc aatgtcctcc
      601 ggagtgattt cttccagatt caatgcttct attaattcaa ctttcagttt atcaatcaat
      661 tcttccatat tctttattgt ttttcaatca gtttaaatac tgctttatag gtgttcttcc
      721 ataattcaca ccacccgatg atgcaatagt tcagtttccc tttttgcatg actatacgtg
      781 cgtatctttc cagtttttcc ggctgatagg cttcagtgat gaaaaaggtg ttttcccctt
      841 gtatcttgtg gcggatgcaa atctcgccgg acactacatt gggtagtgtg taaacaaata
      901 cagccggact ggctgcctgg tctccttccc ggtctatcag ttgctggtgt ctgatgtccg
      961 tatgcagaga ggaagcggca ttggcaagta acatccccat ttccagtggg gcgaatgtct
     1021 taccttccag caagtattcg gcggccacat atcccaattt gcaaaggtca tccattttat
     1081 agaatttcag gttgtttccg catgtttttt tataggtatc acgtataaat gtgccgaaat
     1141 ccggttcttc ggaatgaaaa ataagttcgt tgtttatgaa gacagaactg ttttcaatac
     1201 gaacctcccg tgtacatcgg atttcgggca aggtgttgtc ctcatccttg aacggagtat
     1261 attccggtaa agataagaca atggctgcgt tgcatccgcc gaatcccgaa gcggttttta
     1321 cgcaatgttt catcgggatg ctccggtggg tggcatagac cggtatcggc ataggaattc
     1381 ccggcgtttc gtaacccgga gtgccgaaca ggatgccttg tttcagttcg tgcatacaga
     1441 caatgctttc aatgattccc gatgctccca gggtatggcc gaaatagggc ttcaaactat
     1501 ggacgggcac ttgttccaga tgagccagtg tgagggcttt ggattccatt tcatcattat
     1561 ataaggtagc agtgccgtga gcattcacaa aactgatatc ctgaggggct gttcctgctt
     1621 cctgcatggc ttggcggatg gcgaaataga gtccgtctcc cgtgcgggaa ggaccggaga
     1681 tgtggttggc atcgttactg acggctcctc ccgaaaggat aacatgttct tctgttcctt
     1741 ctgaactgag caatacggct ccgcaggcct ctcccaagtt caatccgtca cggctgctgt
     1801 catacggacg gcatgggcgg gagctgagag accggaaaga cccgaaaccg ctggtgatga
     1861 aatgagagag aaggtcacct cccgctacga ttacccggcg gtagatgccg ttctctatca
     1921 tgcgttttcc tgctatgagg gctgacactc ctgaaatgca ggcattggaa atgacatgca
     1981 cccgttcctc ggcatggaaa taaccggcaa tgttttctgc cattttccaa agaaagaccg
     2041 cttcatcggg atgttccgta tgacgggcca gtaaatcgat gttccctttg gtggtggaga
     2101 ggatgagtcc gcaggttttg tcttccaaag tttgtccgga ctgacggatg agttcgttga
     2161 tagtcagtat gaacagttgt tccatccggg gatagccact tactcctatg gcctccgcct
     2221 gttgttgcaa tctctcttgc gagagagtgg ctgccaatag gggagtgtcc gcaatccgtt
     2281 tgtccgtctg cagggtgata ccgctgtgat agctccggat ggcttccaga ttttcctgtg
     2341 tgccgaaacc cagcgcgctg atcagggtat catgggtgat ataggtagtc agatgatgtt
     2401 ccatttcttt ttccactcta tgtaaaaggc aggattaacc agttccagtt ctctatttgt
     2461 attcaggaat acctgtgtag tggttcctgt tgccacaatg ttttggtccg atgcccggta
     2521 gatggtgtat tcaaaaagga ttttggcagc atcactatga atataccgtg tctcgacaat
     2581 cgcttcctcg ccaaaagaca gcggttgttt gaattggcag gtcaggtcta cgataggaac
     2641 tacatatcct tcccggtaga tgctcatata gtccagaccg taccgctttc cgaaagcttc
     2701 gcgtccgtct tcgaaataac gcacatattc tccatgccat actatctgca tggaatctat
     2761 ctcactgaag cggactttga tggtggtccg gtccgtcagt gccgcctgat gtggacttgt
     2821 ttttcgtttc attctttctt cagatatatt ttcatccggc attcggccag caattcatcg
     2881 ttttctttta cctcggcggt aatcagggtg atatcaaata cttcctgaac gatggttata
     2941 ccggtatata gttccgctcc ggcagaagga agacggaata gtttcatctt ttctaccgaa
     3001 ccgataaaac ctaatggtac aggttctttc cgcagcatat agatataacc tacacgtgcc
     3061 gccgccgact gggcgatatg ctctatgatt cccgtctcct gtaatacacc gtcccggcag
     3121 aacaggttgt cgggagtgac ggtcagccct gaccaggatg tattttcttc tatcccatag
     3181 aagcggtcta tcattaccat gggcgggcgt tggggaatca gccggaacag ctcttctccc
     3241 tgacagatga tttctttgct gctcatttca gtctgcattg caggatactg tgtcccagtc
     3301 ctatgttatc ttgaatttct tccacttcca atccggcatt ttcaatgcag cggatcaggt
     3361 catccgaatg gaacatctta ctgttgccgt tggccattgc tgtaaagtag aggctgattt
     3421 gtgtcaggca ataagatgct gtttcatacc gttggcgatc ccataatgtt tccataatat
     3481 agactttgct gtctttgccg atggattgtg ccacacgggt caggatgctg atgacttctt
     3541 cttccgagaa gcagtccaga aactggctca tccatacagc gtcaaaaccc gtgggaaagg
     3601 gcacgtcccg atccagcaga ttggcgccgt gaccgtgtat gcgttcacta ccggacaaac
     3661 cggccgtttg ctttctcatc atttccagtt gttgaggcag gtccacgatg gttacttcca
     3721 cttccttatt atattgtacg cattgtgtgg cccatctgcc ggtattcccg ccaatatcga
     3781 gcaagcgttt cgggtgatgg ctgaacacga tttccaacgc tttgccgaat gactggtccg
     3841 aatagaaatg atcaaagccg aaccagcttt tctgtacctg ttccggcaat tgggacagac
     3901 cttcgtaaat ggtaggccat tctccgaatn nnnnnnnnng tgccgcatag cgtgtcagtc
     3961 cggtctgccc gctgatttct tgcagcgtat atccttcccg tttgccggac aataattgga
     4021 aaattccgaa tttcaacatc aggcgcgata cttggaatac cacaggaccg aaagctatct
     4081 cttgtgccag tctttgcgct tcggcagccg tacattgttc ttttgtatat cttttatgca
     4141 tcataccaga tttattttta tgtccagaac gggtagtaat tgaaccattg ttccggatac
     4201 tgccggacaa tcttttccag cgtttgtgta tattgctcca ataatgcctg ttcggcccgt
     4261 ttctctttcg tccgtactac tgtctcggct ataaagaaat ggaaacgata cgttctttgg
     4321 gcttcacgca tggcaaaata gaatacgacg ggtactttta acttcgaagc cagcaggaaa
     4381 gggcccatcg gaaatttggc ttcttttccc atgaaagaag tcgtgagtaa tttctcttta
     4441 ttcagatagc ggtctccctg aaagcagaca tactcccggc ggtccagcgc ttccgtgatg
     4501 cggaatacat gtgtcaggct gtcttcattc accggaatta ttttgtagtc tcgcgtagag
     4561 gcgttctttt ccaaaatctc ctttatccgt tcgtgttcgg cgtcaaacat gacgatattg
     4621 atctttttgc catattcatc gaagaaagga gcgcctattt cccagttgcc cacatgggcg
     4681 ccaatcataa ttactccggt gtttccgttt agtacgtcta aaaatgcctg atagttctca
     4741 aacttgaaat gatacttgcc ggtcattccg ttgccgatgg ccactttgtc aatcaatatt
     4801 tgtcccagcc ggtaatagtt tttcaggagc agtgcgacgg atttcagccg tccgtatttc
     4861 agcctgttcc gtgcgtaact ccaagtattg cccgttgctt tcggtgcgaa aggtatgaag
     4921 tagaggacga ccaatgccag gaagccgtag gccgcagtta tccccagaca gcggatcatg
     4981 tagataaaga acatgtatcc gaatatgcct cctcttgtct tacctttcca tgtttcggac
     5041 atcagtcttc tttttgcata tgtgaaatta ccagattata gaaatcctgg aaggttttga
     5101 taccggcaaa atctttggct gtaacggtga aaccgaaatt cttgtcaatc agtactacca
     5161 tatccaccag gtcaaggcta tccaattcca aggtttgcat caagggtgcg tccggttgga
     5221 tctgttctac atcaatctca aattcttcgg ccagggtggt tctgatcttt tcgatgattt
     5281 cttcgttggt cataaattta tatattggtt tgaattaatt gttttcttta aatttacgga
     5341 taatcagtga ggaattggtt cctccgaatc cgaatgagtt ggacaagaag gtgtcaaatt
     5401 ccgtttctat cctccgggag gggatgttca gcagagcaga ggcttcatcg ggttcttcaa
     5461 aattgagatt aggagcgata aatccgttat tcatcatcaa gatggaataa atgacttcac
     5521 tggcgcctgc catccacatc tcatgtccgg tttgtgactt ggtggatgtg acatagggcc
     5581 gatggtttcc aaacacttcc gctatggctt ttgcctcatt caaatctccc acgggggtgg
     5641 aagtggcgtg tgcattgata tattggattt cttccaaggg aatgcccgca tcgttgattg
     5701 ccatctgtaa agagcgtctg ggaccgtcca cattcggtac ggaaatatga tctccgttgg
     5761 atgaaaaacc gtatcctatg acttctgcca gaatagtagc tccgcgcctt acggctgatt
     5821 cataactttc gagtaccagg ctggcgcctc ctccgctggg taccaaaccg tcccgtccct
     5881 tgtcaaaggg gcgcgatgcc ttttccggtt cgtcctcacg ggtggagaac gcgcccaatc
     5941 cgtcgaaact acccacggag taaggattta cctcttgtgc ccctccgcac agaatgcaat
     6001 cctgaagtcc tgatttaata agaagatacg ccatgccgat ggcgtgtgaa ccgctggcac
     6061 aagctcccga tatggtaaaa ttaattccct tcaaatggaa aataaccgaa aggttcatgg
     6121 taatcgtaga gttcatggac tggaagatag aaccggagcc caccatagcc gtattcttct
     6181 tggcacgaat gacatcaatg gcctcgatta ccggagcggc gctactgtca tttccataca
     6241 atatgcctac ttcatgatcc aataaaaact cctcgtctat ttgtgcctga cggaatgcct
     6301 ccaaggtagc catataggca tattctccct gttcggcgag gctatgtctc tttttgcggt
     6361 ccaataactt ctttaaatca ggacgttcga caagtcctgt caatgcggaa aaatacccca
     6421 tctctttacg tgccggatcg atgccgatgc cggaacgccc ttggaacaaa gagtctttca
     6481 cctcatcttg gttcttgcct atgcacgaat aaatacccat gcctgtaatc actactcttc
     6541 tcatcttctg cttatgtata gattcctcca ttgatggaaa ttacttctcc ggtgatatag
     6601 gaggcttgtt ccgatgccag gaagcctacc agtgcggcta cttctccggg ttcgccgaac
     6661 cgtcctgccg gtatctgttt tttccattca ttttcatcaa tgccgttggt catatccgtg
     6721 cggataaatc ccggtgctac ggcgttcacc gtcacgtgtt ttctggccac ttcctgtgcc
     6781 agtgctttgg tggcggctat cattccgcct ttggctgccg aatagttggt ttgtcccggc
     6841 attcctttga tacccgacag ggaaacgatg ttgatgatac gtccgaatcg ctttaccagc
     6901 atatttttca gcaagggttg ggtgacgtta aagaaaccgt tcaggctgat atccaacacc
     6961 cggctccatt catcctgttc catccacagc atcaggttat cacggcgtat accggcattg
     7021 ttcaccagta cctcaatgta ggtatcggga tgcttctcca tccagccgtt cagtgcggcg
     7081 tgtgtggcta ctgcgtctgt cacgtcaaat ttcatcagtt cgccgtccga gccttgttcc
     7141 cgtatctgtt gcagggtggc ttcggcttcc gtatcgttgc tttggtagtt tatcagtata
     7201 tgatatccca tttcggccag tttcagacat acagcccgtc cgatgccccg gcttcctcct
     7261 gttactaatg cgtatttcat ttttcttgaa acctcccttt tttaagatat accatcattc
     7321 tttctatctc tttatattta ggcgtatctt cccggaatac aggaaaaaat gctcgtatct
     7381 ctttatatac ttgttgtgac cgggggctta gccgaccggc tatttccaaa cagtctacag
     7441 cttgtacaat acccatcatc aggatagcca tcacctgata agcattttct atgactgttt
     7501 ttgccagtag tgcggaattg gttcccatgc ttacaatatc ctgattgtca ttgttgttgg
     7561 ggatgctatg cacatacatc ggattggaca aagtctggca ctccgctgtg gtagaagtcg
     7621 cggtaaattg tgacgcctgc aaaccatagt tcaatcccag cactcccata ttgacaaagg
     7681 ggggcagaat gccgttgatg cggtcgtgaa acaagtaatt gatctgccgt tcggcaagca
     7741 tggccagttt ggtgaccgct attttcagtt tatccatttc aaaagaaacg taatctccgt
     7801 gaaaattacc gccatgatac acgttttgcg tgtcggggtc cactatcggg ttgtcacagg
     7861 ctgaatttat ttcgtttatc aatacttttt cggcattgag caattcatca taaaccggtc
     7921 ctagaatctg tgggatgcag cgcaacgaat aatagggttg aaccttatgg gtgaagattt
     7981 tctcttcgtg ttttccgttg taaagttcat tctctctttt gcgtacacat tggctgcctt
     8041 ccacccattg gcgcatcatg cgggctatct cttgctgtcc ttcatgccgt ttggcttcgt
     8101 tcagcggttc ggacatgaaa tcatcgtacg aggcggcaat ttcattcatc atgaccgatg
     8161 cgcctactgc ccaatgcatc agttggcggg cataaatcag gttgacaatg cctatacctg
     8221 tcattaccga agtgccgttg gtcactgaaa gcccttcgcg gatatgcatt ttgaagggtt
     8281 gcaatccgtt ttccgccaaa acggatgccg tatctctttt cttgccttgg taaaagacct
     8341 ctccttctcc aatcagggtg agggcgatat gggcaagctg taccaaatcg ccactggccc
     8401 ctacactgcc gtgttcgggt acgtatggag taatcccccg gttgataaac tcggtaatga
     8461 gcaatgccag ttctttatgt atgccggatt ttccttgcag aaaagtatag agacgcgcta
     8521 tcatggcagc tttgacatag agttccggaa ggggttgccc tgctccggtg gcatggctgc
     8581 ggatgatatt atactgtaat tgtgacaagg attcatcttc aatacggtat tgggccatcg
     8641 gtccaaagcc ggtattgatg ccatagatga tcttgtcgtt ggagaatgtt ttcagaaaat
     8701 ggaaactctc ttccaatttt tgcatacatt ggtcggagag tgtcagtggc tcttcttcaa
     8761 acaaaatctt atacagggac gctaaagtta tcttattctc agctagcatt ggattggtgt
     8821 gataagcagt tttgtataat ttccgcaaaa atagttattt aaaaataagt attaccatcc
     8881 gaagggagat ttttcagttt tgatggttat ctgaaaggtt caccacagat tatacaaata
     8941 aacgcagatg cttcttaagt cattgattgt caggtgggta atctgtgtga atctgtatag
     9001 tctgtggtga aaaatatagt gtcgctctat gtatcctatt tattcagttt ccatgtgaaa
     9061 ccgtctttgg tatctttcac ttcaaagcca agagcggcca gctcatcacg gattttatcg
     9121 cttgtagccc agtctttatt ggctttggct ttcatacgtt gttccagcag catatctact
     9181 actttgccgt atgcctcttc acgtgcctcg ttattggcgg cttcttcttt cagacccagg
     9241 atttcgtaca taaagagatg gaacacactt ttcagttctt ccagatcttc tgcggaaata
     9301 gtggctttct tgtccagaac cgtattaatc atacgggcgc cgtcaaacag atgggcaatg
     9361 acaatcggtg agttcaagtc atcattcatg gctgtataac acttttcacg caagtctttt
     9421 accccctcta tgccggtggt ttgtgttgcc ggagtgatgc gttcaagacc tttcacagct
     9481 tctgtcagcc gttccaatcc tttttcggct gcttgtaatg cttcgttact gaagtccact
     9541 gtactgcggt aatgtgcctg aaggatgaag aaacggatgg tcatggggct gtaggcttgg
     9601 gtcagtaact tgtgggtacc gtggaagaac tcatccaagt taatgaagtt gccgtatgat
     9661 tttcccatct tctgtccatt aatggtaatc atgttgttgt gcatccaata gtgaaccatg
     9721 tcatctcctt gtgaagccac gctttgtgcg atttcacatt cgtggtgtgg gaaaattaag
     9781 tccattcccc ctccgtgaat atcgaaatgc tcgcccaggt atttcttacc cattgcggta
     9841 cattcacaat gccaaccggg gaatccgtta ctccacgggc tgggccagcg catgatatgt
     9901 tcgggttgtg cacatttcca cagggcgaaa tcggcaggat tgcgcttctc gctttgaccg
     9961 tccagttcgc gggtggtgtt tagcacatcg tccaggttgc ggccggacag tttgccgtaa
    10021 tgatggtctt tgttgtattt tgctacatcg aaataaacgg aaccttcact ttcataagca
    10081 tagccgtttt tcagaatttc ttctaccagt tctatctgtt caatgatatg gcctgatgca
    10141 tgtggctcga tactgggtgg aagtacattc aaggcttcca ttgccttgtg gtagcgattg
    10201 aggtaatatt gcactacttc catgggttcc agttgctcca gacgggcctt tttggcgatt
    10261 ttatcttcgc cttcgtctgc atcgtgttcc agatgaccga catcggtaat gttacggaca
    10321 taacgtacct tgtatcccag atgggtaaga taacggaaca ggatatcgaa cgtgatggcg
    10381 gggcgtgcgt gtcctaaatg ggcatcgcca tatacggtag gaccgcatac atacatacct
    10441 acatgagggg catgcaaggg aacgaaaagt tccttttgac ggcttaatgt attgtaaatg
    10501 gttagtttat tttccataat tcattctatt agaattgcaa agttataaat taaagtgtgt
    10561 atttggctaa taattacccc agttcgggat aagattttgt tcataaaaag ttggtagtct
    10621 cataaatat
//
