LOCUS       c00018_gnlPro..        10414 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|AILKLODE_18.
ACCESSION   c00018_gnlPro..
VERSION     c00018_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-07 08:28:07
            Original ID  :: gnl|Prokka|AILKLODE_18
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 10414
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..366
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ILVD_EDD"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg18_1"
                     /sec_met_domain="ILVD_EDD (E-value: 1.7e-45, bitscore:
                     144.6, seeds: 918, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="PGMQEMLYPTSYIKSKHLGKECALITDGRFSGGTSGLSIGHISPE
                     AAAGGAIGLVKDGDIIEINIPERTIHVKVTDEELAKRREAEEARGTKAFTPPFRQRTVS
                     KALKAYAKMVXXXXGVC"
     protocluster    1..10414
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[0:4573]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      1..4573
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..10414
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..10414
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             453..2150
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg18_2"
                     /sec_met_domain="TPP_enzyme_C (E-value: 2.7e-51, bitscore:
                     162.5, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEQKITGSEALLKALIAEGVDTIFGYPGGQAIPIYDSLYDYRDQL
                     KHILVRHEQGATHAAQGYARVSGKVGVTVVTSGPGATNTITGIADALMDSTPMVVIAGQ
                     VPSPLLGTDAFQEVDVIGITQPITKWAYQIRRPEEIAWAVSRAFYIASTGRPGPVVLDL
                     AKDAQVGLVDYEYQKVDYVRSYQPEPDIREERIEAAASLINNAKKPFCLVGQGVILGGA
                     EEELKEFLLKNDIPAGSTVLGLSALPSDFPLNKGMLGMHGNVGPNRKTNECDVLIAIGM
                     RFDDRVTGDLKTYAKQAKIIHLDIDNSEIGKNVPVDVKVLGNAKHTIPMITALLEERKR
                     PEWNAEFEPDEKEEYNKVIEKELYPTEGQLKMGEVVRKVSEATDNDAILVTDVGQNQMM
                     GVRYFKYKQTRSVVTSGGLGTMGFGLPAAIGAKLGAPDRTVCFFTGDGGIQMTIQELGT
                     IMQENLNVKIIVLNNNFLGMVRQWQELFFNERYSNTIMKNPDFVAIAKAFGIASRAVDK
                     REDLDEAIAEMLNHDGAYMLVANVETCGMVYPMVPAGGSVTNMILGDK"
     CDS             2163..2717
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg18_3"
                     /sec_met_domain="ALS_ss_C (E-value: 9e-19, bitscore: 56.7,
                     seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNTKQLYTVIIFSENTVGLLNQITVIFTRRQLNIETLSVSPSAIK
                     GIHKFTITTFADEDTIDKVVKQIDKRVDILKAYYNTDEDLVYQEIALYKLSTELFIKMG
                     TVEDLIRKYNARILEMNEDCVVLEKSGHYDETQALFKELSETIGVLQFIRSGRVAITKS
                     KVERLSDMLSAMEKKLQEKHV"
     CDS             2754..3485
                     /locus_tag="ctg18_4"
                     /transl_table=11
                     /translation="MEKNKVGEFHFVTESYLMDFRGRITIPMIGTYLLHAASCHAADRG
                     FGYNDMTERHTAWVLSRLAIEMTSYPAMSESVTLYTWVDEVGKLFPSRCFELVNGEGKT
                     FGFARSIWAAIDMETRRPTLLDVEGLSAYITDRPCPIEKPGKIAPVENNTSGEPYRVKY
                     SDLDVNGHLNSIKYMEHLLDLFDISLFREKEISRFEIAYQSEGKYGMELTLHNQEVSPG
                     KYNMAICNDGKAISRAAVTWI"
     CDS             3527..4573
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: IlvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg18_5"
                     /sec_met_domain="IlvN (E-value: 9.8e-49, bitscore: 154.2,
                     seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="IlvC (E-value: 2.2e-44, bitscore: 140.3,
                     seeds: 295, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAVMNFGGVDENVVTREEFPLEKAREVLKDETIAVIGYGVQGPGQ
                     SLNLRDNGFNVIVGQRKGGKTWEKAVADGWVPGETLFDIEEACEKATIIQYLLSDAAQI
                     EVWPRIKKYLTPGKALYFSHGFGITYKERTNIIPPADVDVILVAPKGSGTSLRRMFLQG
                     RGLNSSYAIFQDATGKAWDRVIALGIGVGSGYLFETTFKKEVYSDLTGERGTLMGAIQG
                     LLLAQYETLRENGHEPSEAFNETVEELTQSLMPLFAENGMDWMYANCSTTAQRGALDWM
                     GPFHDATKPVFQKLYSEVACGNEAQRSIDTNSKPDYREGLEKELAALRESEMWRAGAVV
                     RKLRPENN"
     CDS             5075..6514
                     /locus_tag="ctg18_6"
                     /transl_table=11
                     /translation="MISVLLGAAGAIAANPTGPETMVVQQGNKVTGLVEDQMGPVAGAS
                     VVVKGTTIGMITDIDGKFTLDNVRRGAVIVISFVGLATQEITWNGQSILNVKLSDATQD
                     LDEVVVVAYGTAKKSTFTGSASVVKAEKLEKIMGSGFAEALQGMSAGVNVVNVQGNPGA
                     DARVEIRGIASMSGKADPLYIVDGMPYDGKLNQINPTDIESMTVLKDAAATSLYGSRAA
                     NGVVMITTKRGKSEKPRINFRGGWGTSDNAVKNPKKADPYQQLENTWYALYYDALLYDG
                     MNMQQAGDYASSQALTKQVKATKDSNGNLIYVTPFRHINENYVLHDGNGNPYMNPNLEY
                     VWDEDDWDVYKAXXXXRKLRQDYSVDISGQANGGKTAYFFSGGYLDDQGYGNRQYYKRY
                     SFRTNLSTELFDWWKVAGSLSYSRHRQNLSGGASRAANFTTTLSSPWLRNEDNTGWVVS
                     EKTGEXXXXXXXXXTSLVPIS"
     CDS             6568..8352
                     /locus_tag="ctg18_7"
                     /transl_table=11
                     /translation="MGHILSAQVNTEFTLPFNLKFRSALNIDDYWYRTMQYTSAVHGSG
                     QTAPYGISILADGGYASRYNFNKRSTTWNNVLSGEWMIGDHTISGLVGHEWYTWDSHYE
                     QGWGEGIMELGKYELSNTTKNFGVSGGRDKYSLLSFFGKVDYNFLNKYYLSASLREDGS
                     SRFSSDHRWGTFWSTGGSWRISKEGFMEDLKWIDNLSLRGSYGTTGNDKLIVRESNGKA
                     GDEVLYGYQGTYESDDLYLKSGLKPSTYPTPDLKWESNQQWNIGLDFSVFNRLSGTVEY
                     YSRTSHDLLYYKELPLSAQVGSASGYNMNIGDLRNSGIEITLNANILTTKDFRWDIDAN
                     MSTLKNEVTYLPTGPYTYSGTACTYKMEEGKSLYEFIAPQYDGVNPETGVPGWLIRDGN
                     GGWKRTEKQEEVTTDDFVYCGSAIPKVFGAITNNFQFKGIDLSFMFYYSYGSKISDYTY
                     KERIMNRPGVGVIQELVEDRWRQPGDTDVLIPRWSYNQYGATVKYADNFVFDNHYWRLR
                     NLTLGYTLPKSLTRKALVENLRVYVTGNNLLTFGPAKKRYTDPETGIMGNSYNGNAETD
                     NGIQGSRRLYMVGIQITL"
     CDS             8371..9960
                     /locus_tag="ctg18_8"
                     /transl_table=11
                     /translation="MKRFINISFLSLVFAGMALTGCNDDLTTSSYVKVNDEDVLGNVSQ
                     LEKVLTSAYKQLYFNTDKGDRVYAGLPGFQMYVDASGADVISHTNMGGDQVTAYQYSNS
                     KTQADGNASKIWSMCYNVINRANIILTNVDAAAGDETQKKHIKGQALAMRGIQYFHLIQ
                     NYQQTYAIAKSKRGVILRTSSDDESHKGFSTVEEVYTQIVSDLTTAKTLLADYNPDDMW
                     LINSKICSGILARVYLVMQNWDGAYNEAKIVYDQHSQLMTREQYRSGFDDMISGNYAEV
                     VWAMKYTADNNLGGSTQFNFWYNQDASYGEGYADGPIYSFLDYFVDEQFVKLFEEKEDR
                     YQFWKRTNNANTEINTKWAFDKYKHYGEDGGSVIQSATRPEVCLMRGAEMLLIMAEAAA
                     QKGNSGEALNLLNRLQVARNATPTTNAGGEALLEDIYVERRKELICEGQAGFYDLVRLQ
                     KRLVRIGESTTNPAGHYVWGMQYLNGYNALDPQPIGTLESNDYRFFCQIPQMEILNNDA
                     ISESDQNPWSGQ"
ORIGIN
        1 ccgggtatgc aggaaatgtt gtatcctact tcttatataa agagtaaaca cctgggtaaa
       61 gaatgtgcgc taatcacaga cggacgcttc agcggtggaa catcaggttt gtcaatcgga
      121 catatttctc ccgaagcggc tgccggcgga gcgattggct tagtgaaaga cggcgatatt
      181 atcgaaatta atattcccga aagaaccata catgtaaagg tgacagacga agaactggcc
      241 aaacgccgtg aagcggaaga ggcccgcgga acaaaagcct ttacacctcc tttccgccaa
      301 cgtacggtat cgaaagcact gaaagcatat gcaaagatgg ttnnnnnnnn nnaaggggtg
      361 tgttaaagtt cagctctatt ggatagcatt aacacacccc ctaccccctc tcaagagggg
      421 aaaggttacc atcagacaat aaaacaacaa atatggaaca aaagataacc ggttcggaag
      481 ctttgctgaa agcgctgatc gctgaaggag tagatactat cttcggttat ccgggtgggc
      541 aggcgatacc aatttacgat agtttatacg attacagaga tcagttaaaa catattctgg
      601 tgcgccacga acaaggtgca acacatgctg cacagggata tgcccgtgtt tccggaaaag
      661 tgggagtaac ggtggttact tcgggtcccg gggcaaccaa taccatcact ggtattgccg
      721 atgcgctgat ggacagtaca ccgatggtgg tgattgccgg ccaggttccg tctccgctgc
      781 ttggaacaga tgctttccag gaagttgatg taattggtat cacacaaccg attaccaaat
      841 gggcttacca gatacgccgc ccggaagaaa ttgcttgggc cgtttcccgt gctttctata
      901 tcgcatcgac cggtcgcccg ggacctgtgg tactggattt ggcgaaagat gcacaggtgg
      961 gtttggtaga ttatgagtat cagaaagtgg attatgttcg tagttaccag cctgaaccgg
     1021 atatcaggga ggaacgtatc gaggcggctg cttcattgat aaataatgcc aaaaagccat
     1081 tctgtctggt agggcagggg gttatcctag gaggagctga agaagaactg aaagaattct
     1141 tgttgaaaaa cgatatacca gccggttcta ccgtattggg cttgtctgca ttaccttcgg
     1201 acttcccatt aaataaaggt atgttgggga tgcatggaaa tgtcggaccg aaccgcaaga
     1261 ctaacgaatg tgacgtgctg attgctatcg gtatgcgttt cgatgatcgc gtaaccggcg
     1321 acttgaagac ttatgccaag caggcaaaga ttatccacct ggatatcgac aattcggaga
     1381 tcggaaagaa tgtgccggtc gacgtgaaag tgctgggaaa tgccaagcat acgattccga
     1441 tgattacggc tttactggaa gaacggaagc gtccggaatg gaatgctgaa ttcgaaccgg
     1501 atgaaaaaga ggaatataat aaggtaatag aaaaagaact ctatcctacc gaaggccaac
     1561 tgaaaatggg cgaagtagtc cgtaaggttt ccgaagcaac cgataatgat gcgattctgg
     1621 ttacggatgt aggtcagaac cagatgatgg gtgttcgcta tttcaaatat aaacaaacac
     1681 gcagcgtagt tacttcagga ggtttgggaa cgatgggctt tggccttccc gccgccattg
     1741 gagcgaagct gggagcgcct gaccgtacgg tctgtttctt taccggcgac ggtggtatcc
     1801 agatgactat ccaggagttg ggaactatca tgcaggaaaa tctgaatgta aagatcatcg
     1861 ttcttaacaa caatttcctg ggaatggtac gccagtggca ggagctgttc ttcaacgaac
     1921 ggtattcgaa taccatcatg aagaatccgg attttgtagc gatagccaag gcttttggta
     1981 ttgcttcccg tgcggtagat aaacgggaag acttggatga ggcgattgct gaaatgttga
     2041 atcacgatgg tgcctatatg ttggttgcca atgtggaaac ttgtggtatg gtatatccga
     2101 tggttccggc cggaggaagc gtgacaaaca tgattttggg tgataagtaa ggaggagaaa
     2161 ctatgaatac aaaacaatta tataccgtta ttatcttttc ggaaaacact gttggtcttc
     2221 tgaatcagat aactgttatc tttacgcgcc ggcaactgaa cattgagacg ctttctgttt
     2281 ctccctctgc tataaaggga atacataagt ttacaattac tacctttgcc gacgaggata
     2341 cgatcgacaa ggtcgtaaaa cagatcgaca agcgtgtgga tatcctgaaa gcttattata
     2401 atacggatga agacctggtt taccaggaaa tcgctcttta taaactgagt accgaactct
     2461 ttatcaagat ggggacggtt gaggatctga tccgtaagta caatgcccgt atccttgaaa
     2521 tgaatgagga ttgtgtggtg ttggaaaaga gtggtcatta tgatgagaca caggctttgt
     2581 ttaaagaatt gagtgagacg atcggtgtcc tgcaatttat ccgttccgga cgcgttgcta
     2641 taacgaagag taaggtagaa cgtctgagcg acatgttatc tgcaatggaa aagaagttgc
     2701 aggaaaaaca tgtctgagaa taataaggaa acattttgta aataaagtaa attatggaga
     2761 agaacaaagt aggagaattt catttcgtaa cagagtctta tctgatggac ttccggggac
     2821 gtattacaat ccctatgatc ggaacttatt tgttgcatgc tgcttcttgc catgccgccg
     2881 accgtggatt cggatataac gatatgaccg aaaggcatac cgcctgggtt ctttcccgtc
     2941 tggctatcga gatgacttct tatcctgcca tgtctgaatc cgtaacttta tatacctggg
     3001 tggatgaggt cggtaagttg tttcccagcc gttgctttga actggtgaac ggcgaaggca
     3061 agacctttgg ctttgcccgc tctatctggg cggctatcga tatggaaacc cgccgcccga
     3121 ccttgctcga tgtggagggc ctgagtgctt atatcaccga ccgtccctgt ccgattgaaa
     3181 aaccgggtaa aattgctccg gtggaaaaca acacttccgg cgaaccttac cgtgtgaagt
     3241 acagtgacct ggacgtaaac ggccacctga acagtatcaa atacatggaa cacctgctcg
     3301 acttgttcga tatcagtctg ttccgagaaa aagagataag ccgtttcgaa atagcttatc
     3361 agtccgaagg aaagtatggg atggagctga ctctccataa ccaggaagta tcccccggta
     3421 aatataatat ggcaatctgt aacgacggca aagccatcag ccgcgctgcc gttacctgga
     3481 tctgaaaaac aaattatttt atatacattt taatagtaaa aagaaaatgg cagtaatgaa
     3541 ttttggcggc gttgacgaaa acgtagtaac ccgcgaagaa tttccgttgg aaaaggcaag
     3601 agaagtattg aaagacgaaa caatcgctgt aataggttac ggcgtacaag gtcctggcca
     3661 gagcctgaac ctgcgcgaca acggttttaa cgtaattgta ggacaacgta aaggtggtaa
     3721 gacctgggaa aaggccgttg ctgacggttg ggtaccgggc gaaacactgt tcgatatcga
     3781 agaagcatgc gaaaaagcga ctatcatcca gtatctgctt tcagatgctg ctcagattga
     3841 agtttggccg cgcatcaaaa aatacctgac tccgggtaag gctttgtatt tctctcacgg
     3901 attcggcatc acttacaaag aacgtacaaa catcatccct cctgctgatg tagacgtaat
     3961 cctggttgct ccgaaaggtt caggtacttc actgcgccgt atgttcttgc agggtcgtgg
     4021 tctgaactca agctacgcaa tcttccagga tgcaacaggc aaagcatggg atcgcgtgat
     4081 tgcactgggt atcggtgttg gttctggtta cttgtttgaa acaacattca agaaagaagt
     4141 ttattctgac ctgaccggcg aacgtggtac tttgatggga gctatccagg gattactgtt
     4201 ggctcagtac gaaactttgc gtgaaaacgg tcacgaacct tctgaagcat tcaatgaaac
     4261 agtagaagaa ctgactcagt cattgatgcc gttgttcgca gaaaacggta tggactggat
     4321 gtatgcaaac tgttcaacaa ctgcacagcg tggtgctttg gactggatgg gcccgttcca
     4381 cgatgctaca aaaccggtgt tccagaagtt gtatagcgaa gttgcctgcg gtaacgaagc
     4441 acagcgttct atcgacacaa acagcaagcc tgactatcgt gaaggtctgg aaaaagaact
     4501 ggctgctctt cgcgaaagtg aaatgtggcg tgcaggtgct gttgttcgta aacttcgtcc
     4561 tgaaaacaac taataaatgg tgatacatta atagttaaac attttgtgat ataaaaacgg
     4621 caatccggct tttcgggttg ccgttttttt atggtttatg taatgtgtta atggttaaaa
     4681 aatgtttttg attgcaactg ttattgattt ttcatcccaa tatgtatgtc attgtttgaa
     4741 tgtggatttt agataaaaaa atcaattaaa tggtggttaa aatatattta ttagagcaat
     4801 aaatatacat aattatgctt gtattaaata atgataagtt atatttgctg atggagatac
     4861 tgtagtttgt agagtggaaa tatagaagga tgttgtgtgt aatgatcagt atatctttgt
     4921 tttagttaac tttattttat tgaaatgtat gccagtcact tttatcttag aaaagtgtaa
     4981 cctctaatga aatgaacgct attgtgatta attttattta attaaagact tgaatttagc
     5041 tatgtggacc aactcaaaac taattagatc actaatgatt tctgtattat taggtgcggc
     5101 aggtgcgatt gctgccaatc ctacaggtcc ggaaacgatg gtagtacaac agggtaataa
     5161 ggtaaccggc ctggtagagg accaaatggg acctgtcgcc ggagcttctg ttgtagtgaa
     5221 aggaaccact atcggtatga taaccgatat cgatggaaag tttacgctgg ataatgttcg
     5281 gcggggagcg gttattgtta tttcctttgt cggcctggcc actcaggaga tcacttggaa
     5341 cggacaatct attttaaatg taaaattaag tgatgcgaca caggacctgg atgaagtcgt
     5401 tgtcgtagcc tatggaacgg ctaagaaatc aaccttcacc ggatcggcct ccgttgtaaa
     5461 agctgaaaaa ctcgaaaaga tcatgggctc cggctttgcg gaagcattgc aggggatgag
     5521 tgccggtgtg aatgttgtga atgtacaggg taaccccgga gctgatgccc gtgtggagat
     5581 ccgtggtatt gcttccatgt ccggaaaggc cgatccgtta tatattgtgg acgggatgcc
     5641 ttacgatgga aaactgaacc agatcaatcc tacggacata gaatcgatga cggtgctgaa
     5701 ggatgcggcg gccacttcgc tttacggttc gcgtgcagca aacggcgtcg taatgattac
     5761 aaccaagcgg ggtaaatcag aaaaaccgcg tattaacttc cgcggaggtt ggggtacttc
     5821 ggataatgct gtcaagaatc cgaaaaaagc cgatccgtac cagcagctgg aaaatacctg
     5881 gtatgccttg tattatgatg cccttcttta tgacggcatg aatatgcaac aggcgggcga
     5941 ttatgcttcg tcacaggcat tgaccaaaca ggtaaaggct acaaaagatt cgaatggtaa
     6001 tctgatttat gtcactccgt tcagacatat caatgaaaat tacgtattgc atgacggcaa
     6061 tgggaatcct tacatgaatc ctaatctgga atatgtctgg gatgaagatg attgggatgt
     6121 ctacaaagct nnnnnnnnnn cccgtaaact gcgccaggat tatagtgtgg atataagtgg
     6181 tcaggccaat ggtggaaaaa cagcctattt cttctccggc ggttatctgg acgaccaggg
     6241 atatggtaac cggcagtatt ataaacgtta ttctttccgt accaacctga gtacagagtt
     6301 gttcgattgg tggaaagtgg ccggtagcct ttcttattcg cgtcatcgcc agaacctttc
     6361 cggtggtgcc agccgtgcgg ctaactttac gacgactttg tcttcaccct ggttacgtaa
     6421 tgaagataat accggttggg tcgtttctga aaaaacaggg gaannnnnnn nnnnnnnnnn
     6481 nnnnnnnnta acttctttgg tgcccatatc ctgaataact cgggtgatta ttgggataat
     6541 ccgaacgatg acagtttcga taacaatatg gggcatatcc tgtctgccca ggtaaataca
     6601 gagtttactc ttcctttcaa cctgaaattc cgttcggctt tgaatattga cgattactgg
     6661 tatcgtacca tgcaatatac ttccgccgta catggcagcg gacagactgc accttatggt
     6721 atttctatac tggcagacgg tggttatgcc agccgttata atttcaataa acgttccacc
     6781 acctggaata atgtattgtc tggtgaatgg atgattggtg accatacgat ttcaggtctg
     6841 gtcggacatg agtggtatac ctgggactcc cactacgaac aaggttgggg tgaaggtatc
     6901 atggaactgg gtaaatatga attatcgaat accaccaaga acttcggtgt ttccggcgga
     6961 cgtgataaat actctctgct ttcgttcttc ggtaaagtcg attataactt cttgaataag
     7021 tattacttgt ccgcttcgct tcgtgaggat ggttcttccc gtttcagttc cgatcatcgc
     7081 tggggtacat tctggtcgac aggcggttcg tggcgaatat cgaaagaagg ttttatggaa
     7141 gacctgaaat ggattgataa cctttcgttg cgtggtagtt acggtacgac tggtaatgat
     7201 aagctgattg tgcgtgaatc gaatggtaag gcaggggatg aagtccttta cggataccag
     7261 ggtacttatg aaagtgatga cctgtatctg aaatccggtt taaaaccatc tacctatccg
     7321 acaccggact tgaagtggga aagtaatcag caatggaata tcggtttgga tttctccgta
     7381 ttcaaccgac ttagcggtac agtggaatat tattcccgta cttcccatga tttgttgtat
     7441 tataaggaac tgcctctgtc tgcccaggtt ggtagtgcat ctgggtataa tatgaatatc
     7501 ggtgacctgc gtaatagcgg gattgaaatc acattgaatg cgaatatcct tacaacgaaa
     7561 gatttcagat gggatatcga tgccaacatg agtacgctga aaaatgaggt gacttatttg
     7621 cctacaggtc cttacactta ttctggtacc gcctgtacct acaagatgga agaaggcaag
     7681 tccctgtatg aatttatcgc tccccagtac gatggtgtta atccggaaac cggagtaccc
     7741 ggctggttga tccgcgatgg taacggcggt tggaaacgta cggaaaagca ggaagaagta
     7801 acgacagacg attttgtgta ctgtggctcc gcgattccca aagtgttcgg tgctatcacc
     7861 aataacttcc agttcaaagg gatcgacctg tcgttcatgt tctattattc ttatggttcc
     7921 aaaatatcgg actatacata taaagaacgt atcatgaacc gtccgggtgt cggtgtgata
     7981 caggagttgg ttgaggacag atggcgtcag ccgggcgata cggatgtgct tatcccacgt
     8041 tggtcgtaca accagtatgg cgcgacggta aaatatgcag ataacttcgt gttcgacaac
     8101 cactactggc gtctgagaaa cctgacatta ggctatacgc tgcctaagag ccttacccgc
     8161 aaggccctgg tagaaaacct gcgtgtttat gtaaccggta ataacctgtt gactttcggt
     8221 cctgccaaaa aacgctacac agaccccgaa acaggtataa tgggtaacag ttataacggt
     8281 aatgctgaaa ccgataacgg tattcagggt tcgagaagac tgtatatggt cggtattcaa
     8341 atcacattgt aaacgtaaaa aatgatattt atgaaacgat ttataaatat atccttcctg
     8401 tccctggttt ttgctggtat ggccctgacc ggatgtaacg acgacctgac aaccagctcc
     8461 tatgtgaaag taaacgatga agatgtactg gggaatgtct cccagttgga aaaagtattg
     8521 acttcagcct ataagcagct gtattttaat accgataaag gcgaccgtgt gtatgctggt
     8581 cttcccggat tccagatgta tgtcgatgcg agtggtgccg acgtgatcag ccataccaat
     8641 atgggaggtg atcaggtaac agcataccag tattccaact caaaaacaca ggctgacgga
     8701 aatgcctcaa aaatctggtc gatgtgctat aatgtgatca accgtgccaa tatcatcctg
     8761 accaatgtgg atgccgctgc cggtgatgag acacagaaga aacatatcaa aggtcaggcg
     8821 ctggcgatgc gtggaatcca gtatttccat ctgatccaga attaccaaca gacgtatgcg
     8881 atagctaaaa gcaagcgtgg ggtgatcctg cgtacctctt ccgatgatga atcccataaa
     8941 ggtttttcta ccgtagagga agtctatacc cagattgtgt ccgacctgac gacggctaaa
     9001 acattgcttg ccgattataa tccggacgat atgtggctga tcaactccaa aatatgttcg
     9061 ggaatcctgg cccgtgttta cctggtgatg cagaactggg acggcgctta caacgaagcc
     9121 aagatcgtct acgaccagca cagccagttg atgacccgcg aacaataccg ttccggtttc
     9181 gacgatatga tctccggcaa ttatgcggaa gtggtatggg ccatgaaata tacagccgat
     9241 aataacctgg gcggtagtac gcagttcaat ttctggtata accaggatgc cagctacggt
     9301 gagggttatg ccgacggccc tatctattcg ttccttgact acttcgtgga tgagcagttt
     9361 gtgaaactgt ttgaagaaaa agaagaccgt taccagttct ggaaacgtac gaacaatgcg
     9421 aatacggaaa tcaatacaaa atgggctttc gacaaataca agcattatgg tgaagacggc
     9481 ggaagcgtta ttcaaagcgc tacccgtcca gaagtctgcc tgatgcgcgg agcagaaatg
     9541 ctgctgatca tggccgaagc tgcagcccaa aagggtaatt ccggtgaggc cctgaatctg
     9601 ctgaaccgtt tgcaggtggc acgtaatgct accccgacaa ccaatgccgg aggcgaagct
     9661 ttgctggaag acatctatgt ggaacgccgt aaagagttga tctgtgaagg acaagccggt
     9721 ttttatgacc tggtgcgcct gcaaaagaga ttggttcgta tcggtgaatc aactaccaat
     9781 cctgccggac attacgtatg gggcatgcag tatctgaacg gatataatgc gctcgatccg
     9841 caaccgatag ggacgctgga gtcgaacgat taccgtttct tctgccaaat cccgcaaatg
     9901 gaaatcctga ataatgatgc gatctccgaa tcagatcaga atccgtggag cgggcagtaa
     9961 gtttcatctg ttgtaaataa ataaaagaga ggaaggtgtt tattacatgc ctccctctct
    10021 tttatttgta acatttgatg ttcactgttt tactttttgt cctttagcac ttcctgtaac
    10081 atggccacct tctcctgctc cgctttcaat aaacgttcgt ataattcaac gactttttct
    10141 aagggggtaa atgtaggatt ataattctgg caattagcat tatcttgcca ggtgccggaa
    10201 aagatattaa tggaagtggc ttcgcctagt tccgtaattg cttcttcggg tatatctaat
    10261 gctttggcaa tcttttcgat tacttccggc tccagattac ttcttttttc gtatgtcgaa
    10321 agggttggta gaaaataaat ccggtttatc tctcataata aatatcggaa agagttgcct
    10381 gataatattt gtaccacaga aaaaacacat caaa
//
