LOCUS       gnlProkkaGLBOEDHD_8    16261 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|GLBOEDHD_8.
ACCESSION   gnlProkkaGLBOEDHD_8
VERSION     gnlProkkaGLBOEDHD_8
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-12-01 21:30:24
            Original ID  :: gnl|Prokka|GLBOEDHD_8
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16261
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16261
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[5907:6261]"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5908..6261
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..16261
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..16261
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             723..3551
                     /locus_tag="ctg8_1"
                     /transl_table=11
                     /translation="MKNLIALTLLLGGSTLLCAQKPAKTPATYKPVKSEMYRKGWIDFN
                     KNGVKDVYEDPSAPLEARIENLLQQMTLDEKTCQMVTLYGYKRVLKDDLPTPEWKELLW
                     KDGIGAIDEHLNGFQQWGLPPSDNAYVWPASRHAWALNEVQRFFVEDTRLGIPVDFTNE
                     GIRGVESYRATNFPTQLGLGHTWNRELIRQVGLITGREARMLGYTNVYAPILDVGRDQR
                     WGRYEEVYGESPYLVAELGIEMVRGLQHNHQVAATGKHFAAYSNNKGAREGMARVDPQM
                     SPREVENIHIYPFKRVIREAGMLGVMSSYNDYDGIPVQGSYYWLTTRLRGEMGFRGYVV
                     SDSDAVEYLYTKHGTAKDMKEAVRQSVEAGLNVRCTFRSPDSFVLPLRELVKEGGLSEE
                     VINDRVRDILRVKFLIGLFDAPYQTDLADADREVEKEENEAIALQASRESIVLLKNAGE
                     LLPLDINSTKKIAVCGPNANEEGYALTHYGPLAVEVTTVLEGIQEKTKGKAEVLYTKGC
                     DLVDAHWPESEIIDYPLTDDEQAEIDKAVENARQADVAVVVLGGGQRTCGENKSRTSLD
                     LPGRQLQLLQAIQATGKPVVLILINGRPLSINWADKFVPAILEAWYPGSKGGTALADIL
                     FGDYNPGGKLTVTFPKTVGQIPFNFPCKPSSQIDGGKNPGPTGNMSRINGALYPFGYGL
                     SYTTFEYSDLDITPRVITPNESATVRLKVTNTGKRAGDEVVQLYIRDVLSSITTYEKNL
                     AGFQRIHLEPGEAQELSFTIDRKHLELLDADMKWVVEPGDFVLMAGASSEDIRLNGTLT
                     VEDYQTRAKAIEAQKPAKRVSASTNPEDAENVLDEKINTAWQGNKGDYITFALKNGAKV
                     DKVAIAFTRDNNLPATFEIQLSGGGGQFLTVYSGTVSEYGKLISYPFKGTTASDLRIVL
                     NDDRVSIAEVKF"
     CDS             3653..4780
                     /locus_tag="ctg8_2"
                     /transl_table=11
                     /translation="MKTLLFCMLGLGLTACGSSPKGTNGDQDELAMLIGTYTNGSSKGI
                     YTFRFNQETGTAVPLSSAALPNPSYLVPSEDGEFVYAVSEMNDSTAALSSLAFDRETGE
                     LRLLNTVPTFGADPCYVATNGREVLTANYSGGTMSVFPLQKDGTLAPADTLFQGSATGP
                     DAIRQATPHIHCTVFSPDGKYIFATDFSADRILRFVMHPDDPIPHASLEAVDIEADSGP
                     RHLTFSPNGKFAYLITELSGKVIAFSYDDGCLEQIQTITADTVAARGSADIHLSPDGKY
                     LYASNRLKEDGIAIFAVNPENGTLAKVGYQPTGIHPRNFNITPNGKYLLAACRDSNVIQ
                     VYKRNEVTGLLEDTHQDIVVDMPVCVQFVSSVNNL"
     CDS             4851..5900
                     /locus_tag="ctg8_3"
                     /transl_table=11
                     /translation="MKKNILMLSALFLSITAMAQTDVTTGVMRGKDYGVTYMLPKTEIE
                     IVLQATKHTYTPGEFCRYADRYLRLNNVSAEPEEFWTLDKIETRIAGVPDKDNVYFVKM
                     KDKTVAPLMELTEDGIVRSINIPFSGKPAAKTPEAKATESSIDPRSFLTEEILMSNSSA
                     KMAELVAKEIYSIRESKNALLRGEADNMPKDGAQLKLMLDNLNQQETAMTEMFSGKIKK
                     EPKTFTIRLTPKEMKDEVAFRFSRKLGVVANNDLAGEPYYISVTDLKSPDVSATEEGKK
                     KVDGVAYNLPGKAQVTLMYNNKKLFDDQLPITQFGTVEYLAPVLFNKNSTIKVLFDTAT
                     GGLIKVDRE"
     CDS             complement(5908..6261)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg8_4"
                     /sec_met_domain="PqqD_RRE (E-value: 6.6e-10, bitscore:
                     30.9, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 1.2e-16, bitscore: 53.1,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMEIPEGKVSLLDAVPVRCGHITTEWEGECAVLAYPRFKYEWMRR
                     FLLPKGMSPDIHVRLEEHGTAVWNLIDGHRTVREIISLLARHFGEEENYIPRVTAYVMQ
                     LRKDGFIQLTIRN"
     CDS             complement(6281..7672)
                     /gene_functions="transport (smcogs) SMCOG1106:major
                     facilitator transporter (Score: 102; E-value: 4.6e-31)"
                     /gene_kind="transport"
                     /locus_tag="ctg8_5"
                     /transl_table=11
                     /translation="MTEQLKLKLNDSKATRWGALVIVAFTMMVAYYVNDVVAPLKTMLE
                     TDLAWSSTDFGFFTGGYSFLNVFFLMLIWGGLILDRFGIRFTGKLATILMVGGTALEYY
                     AMTGLAGADATLFGINEIFGYKTGVFVAFAGYSIFGVGAEVAGITVSKIIAKWFKGKEL
                     ATAMGVQVALARIGSQAGYAVAIPLARAFGISTPVLLGLVLLLGGMIAFFIFAVMDKKL
                     DKQMEAAAIAAGTEDEEEKFSFKDVKNILVNPGFWLIALLCVLFYSCVFPFQKFASELM
                     IIKYGINENVAGTFAGLPALGALILTPVFGGFIDKRGKSASIMLLGSAMLICVHFIYAI
                     PDINYWLVAIVLMIILGIAFSLVPSAMWPAVAKIFPVSQLGTAYALIFFIQNIGLWGIP
                     TLIGWVLDAYCISGKKPDGTNMYDYTVPMCIFTGIACLSLIVALLLKKADKKYGYKLEE
                     PNIQK"
     CDS             complement(7826..8215)
                     /locus_tag="ctg8_6"
                     /transl_table=11
                     /translation="MYLLLVILMLIASVLMCFIVLIQNSKGGGLASGFSSSNQIMGVRK
                     TTDFLEKATWTLAAVMVVFSIVSAYTIPSSTGKGGDVILEQAQQEEKTNPYNMPVGTEA
                     PQSEAPAATTPAETPAPAAEAPAAE"
     CDS             complement(8220..8993)
                     /locus_tag="ctg8_7"
                     /transl_table=11
                     /translation="MTPTHLQQWIQHPETLNRDTLYELRTLVARYPYFQSLRLLYLKNL
                     YLLHDINFGAELRKAVLYVADRRVLFYFIEGDRYTLKSRKVSSLFSGDLEKEPSVDRTL
                     SLIDAFLATVPEEHSQHTELDYAVDYTAYLMQEEPGVDAEDESEVPKLRGHELIDDFIQ
                     KSESSDASDTRREFLVEKEEETEEEEEPSVSPVTEELDDSCFTETLAKIYIKQHRYDKA
                     LEIIKKLSLNYPKKNAYFADQIRFLEKLIINAKSK"
     CDS             complement(8998..9522)
                     /locus_tag="ctg8_8"
                     /transl_table=11
                     /translation="MDWIKKAAFASLLVSLLFLVNSCSMKLGLAPISSIDYTKVKTISI
                     ADFQNRAEYVYAPLATEFNQKMKDMFIQQTRLQLVNSGGDLEIDGEITGYNQYNESVDA
                     SGYSSKVKVTLTVNVRYTNNTNHEEDFEQQFSAFQTYDSSKLLTEVQDQLITLMVKDIA
                     EQIFNATVANW"
     CDS             complement(9509..10759)
                     /gene_functions="regulatory (smcogs) SMCOG1112:sigma-54
                     dependent trancsriptional regulator (Score: 379.9; E-value:
                     3.1e-115)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg8_9"
                     /transl_table=11
                     /translation="MTKAEIQQVKLRFGIIGNNEALMRAIDIAIQVAPTDLSVLITGES
                     GVGKESFPQIIHQYSRRKHGQYIAVNCGAIPEGTIDSELFGHEKGAFTGAIGERKGYFG
                     EANGGTIFLDEVGELPLPTQARLLRVLESGEFIKVGSSKVEKTDVRIVAATNVNLTQAI
                     ADGRFREDLYYRLNTVPIQVPPLRERGEDVVLLFRKFASDFAEKYRMPAIQLTEDGKQV
                     LLGYSWPGNVRQLKNITEQISIIETNREINASILKGYLPEQNNMQRLPALFGVKEDKSF
                     GSEREILYQVLFDMRQDVTDLKKLVHEIMAERGTVANPAVATSAYYTPATPAVVPPVTS
                     SVPTIIHPSVKPVTPVDDDFQDTEEYVEESLSLDEVEKEMIRKALEKHHGKRKSAAQDL
                     NISERTLYRKIKEYGLD"
     CDS             complement(10761..11858)
                     /locus_tag="ctg8_10"
                     /transl_table=11
                     /translation="MEDNKIRVGITQGDINGVGYEVILKTFADPVMLELCTPIIYGSPK
                     VAAYHRKSLDLPTNFSIVNSASEAVPNRLSVVNCTDDEVKVEFSKPDVEAGKAALGALE
                     KAIEEYKEGMIDVIVTAPINKHTIQSEEFAFPGHTEYIEQKLGDGEKALMILMKDDFRV
                     ALVTGHIPVKEIAGSITKELIQEKLKIFNRSLKQDFAISAPRIAVLSLNPHAGDGGLLG
                     TEEQEIIIPAINEMAAKGMLCYGPYPADGFMGSDNFTHFDGILAMYHDQGLAPFKALAM
                     DEGVNYTAGLPVIRTSPAHGTAYDIAGKGIASEDSFRQAIYVAIDVFRNRQREKEAHAN
                     PLRKQYYEKRDDSDKLKLDSVEEDL"
     CDS             complement(11864..12919)
                     /locus_tag="ctg8_11"
                     /transl_table=11
                     /translation="MRKHLFYLSMVLVLTLFSACGGGKKGVFTPTSSGRAYEVLVVVEP
                     GLWERPAGRALFDVLDSDVPGLPQSERSFRIMYTAPSNYDATLKLIRNIIIVDVNKDLY
                     TQPKFKYARNVYAAPQSILTIQAPDEASFEKFVEENRQVIIDFFTHAEMNRQISVLKDK
                     HSDYIATKVKSQFDCDVWVPGELTSTKEGENFFWAGTNAATGDQNFVIYSYPYTDKDTF
                     TKEYFVHKRDSVMKVNIPGAREGMYMSTDSLMTDVRPISVQGDYALEARGLWRIKGDFM
                     GGPFVSHVRLDKANQRIIVSEIFIYSPDKMKRNLVRQMEASLYTLKLPGSKQEGTEIPV
                     GVTSKDTTNNK"
     CDS             complement(12990..14030)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg8_12"
                     /sec_met_domain="PF04055 (E-value: 1.2e-16, bitscore: 53.7,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQKRPLLGLTLSELQNVVKNLGMPGFSAKQIASWLYGKKVTSIDE
                     MSNLSLKHRELLKEIYEVGAEAPVDAMRSVDGTVKYLYRAGEGHFVEAVYIPDEDRATL
                     CVSSQVGCKMNCKFCMTGKQGFTANLTSNQIINQINSLPERDKLTNVVMMGMGEPLDNL
                     DEVLKALEIMTASYGYAWSPKRVTLSSVGLKKGLQRFIEESDCHLAISLHSPIPLQRRE
                     LMPAEKAFSITEIVELLRNYDFSKQRRLSFEYIVFKGVNDSLPYAKELLKLLRGLDCRI
                     NLIRFHAIPGVNLEGADMETMTAFRDYLTSHGLFTTIRSSRGEDIFAACGMLSTAKQEE
                     NKEELI"
ORIGIN
        1 accgctttct ttggcccaaa gatacatatt cttttattag caatcaccat atatttacaa
       61 atattagcta atactgactt ttcgtgataa aaacaataat cttccataca tagaatatgt
      121 gcaccccatt gtcatcaatg ttcaaacagc taccaaagcc agtatccgtt gacggaatta
      181 ccccctgcaa gagggaatat ctatcttctg taatggatat ttgcacaaaa gagatgggaa
      241 attaacggaa aaagtctctg aagttaactg aaaaaccgga aagaattaag gaagcaatct
      301 atcccaaact ttggtttttt catacccagc cttgggatgt ctaaaccaag gtttggttta
      361 gacatcccaa ggttgaaaag aaagttcttc cgtacaagca acaattccgc caacagattc
      421 ctattatata aatacaccct cgtttaacag atgtagccgt aatacttgta tacaccgcga
      481 ttgcatctac ttttcaggtt attatagtgt tctctctttc tttttaaaag tgaatgatat
      541 gtttcgtcta ataatgattt gaattccccg gtagcgtctt ggaggatatt tttagtaaga
      601 ggaagaccct tcggacaata aaagccgata cttcggacta ttttatccct ttatttcaca
      661 cattagccgt atttttgtca acaaaagaaa caataataac caagagattt ttagaacata
      721 tcatgaagaa ccttattgcc ctaaccctgc tgcttggagg aagcacactg ctctgcgcac
      781 aaaagcctgc caaaacaccg gcaacctaca agccggtgaa aagtgaaatg taccgcaaag
      841 gttggataga cttcaacaaa aacggagtga aagacgtgta cgaagacccc tccgccccgc
      901 tcgaagcacg catcgaaaac ctgctgcaac agatgacgct ggacgaaaag acctgccaaa
      961 tggtcaccct ctacggttac aaacgtgtac tgaaagacga cctccccacc cccgaatgga
     1021 aagagctgct ctggaaagac ggtatcggcg ccatcgacga acacctaaac ggcttccagc
     1081 aatgggggct gcctccctcg gacaatgcct acgtctggcc cgcctcgcgc cacgcctggg
     1141 cactgaacga ggtgcaacgg ttctttgtgg aagatacccg tctcggtatc cccgtagact
     1201 ttaccaacga aggcatacgc ggcgtggaaa gctaccgcgc caccaacttc cccacccaac
     1261 tgggactggg acatacctgg aaccgtgaac tgattcgcca agtaggactc atcaccggac
     1321 gcgaagcccg catgctgggc tacaccaacg tctacgcccc catcctcgac gtaggacgcg
     1381 accagcgctg gggacgctac gaagaagttt acggcgaatc tccctacctc gtagccgaac
     1441 tgggcatcga aatggtgcgc ggcttgcagc acaaccacca agtggccgcc accggcaagc
     1501 actttgccgc ttacagtaac aacaaaggcg cccgcgaagg catggcacgc gtggacccgc
     1561 aaatgtcgcc gcgcgaagtg gaaaacatac acatctaccc cttcaaacgc gtcatccggg
     1621 aagctggcat gctgggcgta atgagttcgt acaacgatta cgacggcatc cccgtgcagg
     1681 gcagctacta ctggctcacc acccgcctgc gtggcgaaat gggattccgt ggctacgtcg
     1741 tatccgacag tgacgccgta gaatacctct acaccaagca cggcaccgcc aaagacatga
     1801 aagaagccgt ccgccaaagc gtggaagccg gactgaacgt acgctgcacc ttccgctcgc
     1861 ccgactcctt cgtccttccc ctccgcgaac tggtgaagga aggcggactg agcgaagaag
     1921 tcatcaacga ccgcgtgcgc gacatccttc gggtaaagtt cctcatcggt ctgttcgatg
     1981 ccccctatca gacagacctt gccgatgccg accgtgaagt ggaaaaagaa gagaacgaag
     2041 ccattgcctt gcaggcatcc cgcgagtcca tcgttctgct gaagaatgcc ggtgaactat
     2101 tgcccttaga catcaactcc accaagaaga ttgccgtctg tggtcccaat gccaatgaag
     2161 aaggctacgc gctgacccat tacggcccac ttgccgtaga agtgaccact gtgctggaag
     2221 gcattcaaga aaagacaaaa ggcaaggcag aggtgctcta caccaaaggc tgcgacctgg
     2281 tggacgccca ctggcccgaa agtgaaatca tagactatcc gctgaccgac gacgaacaag
     2341 ccgagataga caaagccgta gaaaatgccc gtcaagctga tgttgccgtc gtagtattgg
     2401 gcggcggaca acgcacctgc ggcgaaaaca aatcgcgcac cagcctcgac ctgcccggtc
     2461 ggcagttgca actgcttcaa gccatacaag ccacgggcaa gcccgtcgta ctgatactca
     2521 tcaacggacg cccgctctcc atcaactggg cagacaagtt cgtccccgct atcctcgaag
     2581 cctggtatcc cggctccaaa ggcggaacag ccctggccga catcctcttc ggcgactaca
     2641 accccggtgg aaagctgacg gtgaccttcc ccaagaccgt agggcaaatc cccttcaact
     2701 tcccctgcaa accttcttca cagatagacg gcggtaagaa tccgggacct acgggcaaca
     2761 tgtcacgcat caacggagca ctctacccct tcggttacgg cttgagctac accaccttcg
     2821 agtactccga cctcgacatc accccccgag tcatcacccc gaacgagtct gccaccgtcc
     2881 gcctgaaggt gaccaacacc ggcaaacgtg ccggagatga agtagtgcag ctctatatcc
     2941 gcgacgtact gagcagcatc accacctacg aaaagaatct tgcaggcttc cagcgcatcc
     3001 acctcgaacc gggcgaagcc caggagctgt ccttcaccat cgaccgcaag cacctggagc
     3061 ttctggacgc tgacatgaaa tgggtggtgg aacccggcga cttcgtgctc atggccggcg
     3121 cctcttccga agacatccgc ctgaacggaa cgctgaccgt agaagactac cagacccgtg
     3181 ccaaagccat tgaagcccaa aaaccagcaa agcgtgtgag tgccagcacc aacccagagg
     3241 atgccgaaaa cgtgctcgac gaaaaaatca ataccgcatg gcaaggaaat aagggagatt
     3301 atattacctt tgccttaaag aacggagcca aggtagataa agttgccatt gcctttacac
     3361 gtgacaacaa cctgccggca accttcgaaa tccagctctc gggcggtggc ggacagttcc
     3421 tcaccgtata ttcgggcacc gtcagcgaat acggcaaact gatttcctat ccgttcaaag
     3481 gcactaccgc cagcgacctc cgcatcgtgc tgaacgatga ccgcgtcagt attgccgaag
     3541 ttaaatttta atgtgctaat gtgccaatat gctaatgtac caatgaccat gcagcatata
     3601 cagcgcagcc aattagcaca ttagcatatt ggcacattaa cacattaaat taatgaaaac
     3661 acttcttttc tgtatgctcg gattaggttt gacagcatgt ggctcttctc caaagggcac
     3721 taacggtgac caggacgaac tcgccatgct aataggtact tacacgaatg gctcaagcaa
     3781 gggtatctat accttccgct ttaatcagga gacgggaaca gccgttccgc tcagttcagc
     3841 ggcattgccc aatccctcct acctcgtccc ctcggaagat ggcgaatttg tctatgccgt
     3901 cagtgaaatg aacgacagca cagcagccct cagctccctt gccttcgacc gggaaacggg
     3961 agaactgcgc ctgctgaaca ccgttcccac cttcggcgcc gacccctgct acgtggccac
     4021 caatggccgg gaagtgttga ctgccaacta cagcggtgga accatgtccg tctttccttt
     4081 acagaaagac ggcactttgg ctcctgcaga cacgctcttt caaggctctg ccaccggtcc
     4141 cgacgccata cggcaagcca ctccccacat ccattgcacg gtcttttcac cggacggaaa
     4201 atacatcttt gccaccgact tcagtgccga ccgcatcctg cgctttgtga tgcaccccga
     4261 cgaccctatt cctcatgctt ctctggaagc cgttgacatt gaagcggatt ccggcccgcg
     4321 ccatctgaca ttcagcccta acgggaagtt tgcctatctc atcaccgaac tgtccggtaa
     4381 ggtcattgcc ttcagttacg acgacggctg cctggaacag atacagacta tcacagccga
     4441 caccgtagcc gcccgtggaa gtgcagacat ccacctcagt ccggatggga aatacctcta
     4501 cgccagcaac cgtctgaaag aagacggcat cgccatcttt gccgtgaatc ccgaaaatgg
     4561 gaccttggca aaggtaggtt atcagcccac cggcatccat ccccgcaact tcaacatcac
     4621 gcccaacggc aaatacttgc ttgccgcctg ccgcgacagc aatgtcattc aggtatacaa
     4681 acgaaacgaa gttaccggac tcttggaaga tactcatcag gacattgtag tcgacatgcc
     4741 ggtttgcgta cagttcgtca gctctgttaa taatttataa agcaatattt agcaaagata
     4801 acttcattaa ctttgtccct tagctaaatc agtctaaacg aatgtacatt atgaagaaga
     4861 atatattgat gctctcagct ctgttcttgt ctatcactgc catggcgcaa acagacgtaa
     4921 ccaccggtgt gatgcgtggc aaagactacg gagtgactta tatgttgccc aaaacagaaa
     4981 tagaaatcgt attgcaagcc accaagcata cctacactcc cggagaattt tgcagatatg
     5041 ccgaccgcta tctgcgtctc aacaacgtgt ctgccgaacc cgaggagttc tggacactgg
     5101 ataagataga aacccgcata gccggtgtac cggataagga caacgtctat ttcgtgaaga
     5161 tgaaagacaa gaccgtagca ccccttatgg agcttaccga agacggaatt gtccgctcca
     5221 tcaacattcc gttcagcggt aagcctgctg ccaagacgcc cgaagccaaa gccaccgaaa
     5281 gcagcattga cccacgcagt tttctgacgg aagaaatact gatgtccaac tccagtgcca
     5341 agatggccga gctggtggcc aaggaaatat acagcatccg cgaaagcaag aatgccctcc
     5401 tgcgcggcga agcagacaat atgcccaagg acggcgccca actcaagctg atgcttgaca
     5461 atctgaacca gcaggaaacg gctatgacgg aaatgttctc gggcaaaata aagaaagaac
     5521 ccaagacatt caccatccgg ctgacgccta aagagatgaa agatgaggtg gctttccgtt
     5581 tttcccggaa gctgggagtg gtggccaata atgaccttgc cggtgaaccg tattatatca
     5641 gcgtcaccga cctcaaaagt cccgatgtat ctgccaccga ggaaggcaaa aagaaagtgg
     5701 acggtgtagc ctataacctt ccgggcaagg cacaagtgac attgatgtat aacaataaga
     5761 aattgtttga cgaccaactt cccattaccc aattcggcac cgtagaatac ctcgcaccgg
     5821 tactgttcaa caagaattct accatcaaag tgctgtttga tacggcaacg ggaggattga
     5881 taaaagtaga tagggaataa aggaattcta attccggatt gtcaactgga taaatccatc
     5941 cttacgcaac tgcattacgt aggcggtgac ccggggaata taattctctt cctccccaaa
     6001 gtgcctggca agtagagaga tgatttcgcg cacggtacga tgtccatcta tcagattcca
     6061 gacagctgta ccgtgttctt ccagcctcac atggatgtca ggagacatcc ccttcggcaa
     6121 taaaaaacga cgcatccatt cgtatttaaa ccgtgggtag gcgagtacgg cgcactcacc
     6181 ttcccattcg gttgttatat gtccacagcg gaccggaaca gcgtccaaca gacttacttt
     6241 tccttcgggt atttccatca tacggtatcc gcttttccta ttatttctga atattaggct
     6301 cttccagctt ataaccatac ttcttgtctg ccttcttcag cagtagagcc actataaggg
     6361 acaagcaggc aataccggta aaaatgcaca taggcaccgt atagtcatac atattcgttc
     6421 catctggttt cttgccggat atacaatagg catcaagcac ccaccctatc aatgtaggaa
     6481 taccccaaag accgatattc tggataaaga aaatcaatgc gtatgccgta cccaactggc
     6541 ttaccgggaa tatcttggcc acagccggcc acatggcaga aggtaccagc gagaaagcga
     6601 tacccaaaat tatcatcagc acaatagcta ccagccaata gtttatatcg ggaatagcat
     6661 aaatgaaatg cacacatatc agcatggccg agcccagcag catgatagat gcggacttgc
     6721 cccgcttgtc aatgaaacca ccaaagaccg gagtcagaat cagcgctccc aatgccggaa
     6781 gtccggcaaa tgtaccggcc acattctcat tgataccgta tttgataatc atcaactcgg
     6841 aagcaaactt ctggaatggg aatacacaag agtagaacaa tacacacagc aatgctatca
     6901 gccagaaacc gggattgacc agaatattct tcacatcctt aaaagagaac ttctcttcct
     6961 catcttccgt accggcagca atggcagcag cttccatctg tttgtccagc ttcttgtcca
     7021 tcactgcaaa gatgaagaaa gcaatcatac cgcccaacaa cagaaccaaa cccaacaaca
     7081 ccggtgtgga aataccgaaa gcgcgggcca aaggaatggc tacggcataa ccggcttgcg
     7141 aaccgatacg tgctaaagcg acttgtaccc ccatagccgt ggcaagctct ttccccttaa
     7201 accacttggc tatgattttg gaaactgtaa taccggcgac ctccgctcct actccaaaaa
     7261 tggaataacc ggcaaaagca acaaacacac ccgttttata gccaaatatt tcattgattc
     7321 cgaataaagt cgcgtcggca ccggcaagtc ccgtcattgc atagtattca agtgctgtac
     7381 cacctaccat caggatagtt gccagctttc cggtgaaacg gataccaaag cggtcgagga
     7441 ttaatcctcc ccaaatcaac atcaggaaaa aaacattcag aaaactataa ccaccggtaa
     7501 agaatccgaa atcggtactc gaccaagcca agtccgtttc caacattgtc ttcaacggtg
     7561 ctaccacgtc gtttacataa taagctacca tcatcgtgaa ggcaacaatc accaatgccc
     7621 cccaacgggt agccttggaa tcattcaatt taagtttgag ttgttctgtc attgtactat
     7681 ttggatttca atttattaat cagattgcat aaattgctga caaaggtaaa taaatacttc
     7741 atcaaaacga aaaaaggctg acaccttttc agtatcaacc tttctcttat ttttccaagc
     7801 gggagtcatc cgcaatatcc ttatcttatt ctgctgcagg ggcttctgct gcaggagcag
     7861 gagtttcagc cggagttgta gctgcagggg cctccgattg cggagcttct gtacctacgg
     7921 gcatgttata aggattagtt ttttcttctt gttgcgcctg ttccagaatc acatcaccgc
     7981 ccttgcctgt ggaagaagga atagtgtaag cagaaacaat actgaagact accatgacag
     8041 ctgccagagt ccaggttgct ttttccaaaa agtccgtagt cttgcgcaca cccataattt
     8101 ggttggatga tgaaaagcct gatgccagac cacctccttt agaattttga atcaatacaa
     8161 tgaagcacat cagcacagat gcaatcagca ttaagataac taataataaa tacattttgt
     8221 tattttgatt tagcgttaat aatcaatttc tccaaaaatc tgatttggtc tgcaaagtaa
     8281 gcattttttt ttggataatt caaacttaat tttttaataa tttcaagcgc cttgtcatat
     8341 cggtgctgtt ttatatagat tttggctaaa gtttccgtaa aacagctatc gtccaactct
     8401 tccgttaccg gcgatactga gggttcttcc tcttcttcag tctcttcctc cttctctaca
     8461 agaaactccc ttctcgtatc cgaggcatcc gaagactcac tcttttggat aaagtcatct
     8521 atcaattcat gcccgcgcag tttaggcact tccgactcat cttctgcatc cacaccgggt
     8581 tcttcctgca ttaaataggc cgtataatcc accgcataat ccagctccgt atgctgtgaa
     8641 tgctcttcgg gaacagtagc cagaaatgcg tcaatcaagg aaagggtacg gtccacactc
     8701 ggctctttct ccaaatcgcc ggaaaacagc gacgagacct tccgggattt caaagtatag
     8761 cggtcaccct ctataaagta aaacagcaca cgacggtctg ccacatacaa cacagccttg
     8821 cgcaactccg cgccaaagtt gatgtcgtgc agcagataga ggtttttcag atagagcaaa
     8881 cggagcgact ggaaataagg atagcgtgcc accaatgtgc gaagctcgta caaagtatcc
     8941 ctattcagcg tctcgggatg ctgaatccat tgttgcaaat gggtaggcgt catgagttta
     9001 ccagttagct acagttgcat tgaaaatctg ttcggcaatg tctttcacca tcaaggttat
     9061 cagctggtcc tgcacttcgg tcagcaattt tgaggaatca taggtctgga aagccgagaa
     9121 ctgctgttca aagtcctcct catggttcgt gttattggtg tagcgcacgt tgacagtcag
     9181 cgtcaccttc accttcgaag agtagccgct ggcatccacc gattcattat attgattgta
     9241 gccggttatt tctccgtcta tttccaggtc tcctccggaa ttcaccagtt gcaggcgagt
     9301 ctgctgaatg aacatatcct tcattttctg gttaaattct gttgccagcg gtgcatatac
     9361 atactctgcc cggttctgga aatcggcaat ggaaatcgtt tttacctttg tatagtcgat
     9421 agagcttatc ggagcaagtc ccaacttcat actacatgaa ttcaccagaa ataacaagct
     9481 taccaacaag gaagcaaatg ccgctttttt aatccaatcc atattctttt atctttctgt
     9541 ataacgtacg ctcagagata ttcaaatcct gagccgcact cttacgcttg ccgtgatgtt
     9601 tttcaagcgc cttacgtatc atttctttct ccacttcatc cagggagagt gactcctcca
     9661 catattcttc cgtatcctgg aaatcatcgt ccaccggagt aaccggcttt accgaaggat
     9721 gtataatggt ggggacactg gatgttaccg gaggtaccac cgccggagta gccggcgtat
     9781 agtaggccga tgtggcaacc gccggattgg ctaccgttcc cctttcagcc ataatctcat
     9841 gcaccaactt tttcaagtcc gttacatcct ggcgcatatc aaacagaacc tggtagagaa
     9901 tttcccgttc actcccaaag ctcttgtcct ccttcactcc aaacaaggca ggcaggcgct
     9961 gcatattgtt ctgctcaggc agatagccct tcagtatgga tgcattgatt tcacgattgg
    10021 tctcaatgat ggatatctgc tcggtgatat tcttcaactg gcgcacatta cccggccatg
    10081 agtagcccag caacacttgc ttgccgtctt ccgtcagctg aatggcaggc atacggtact
    10141 tttctgcaaa gtccgaagca aactttcgga acagcagcac cacgtcttca ccgcgttcgc
    10201 gcaatggagg gacctgaata ggaactgtgt tcaaacggta atacaagtct tcacgaaaac
    10261 gtccgtcagc aatggcttgt gtcaagttta cattggtagc ggcaacaata cgcacatcgg
    10321 tcttttccac cttagaagaa cctactttga tgaattcacc gctctcgagc acacgcaaca
    10381 agcgtgcctg ggtaggcaaa ggcaattcgc cgacttcatc aaggaagatt gttccgccgt
    10441 tggcctcacc gaaatacccc ttccgttcgc cgatagcccc ggtaaatgcg cccttctcat
    10501 gaccgaacag ttccgagtca atcgtccctt cgggaatggc tccacagttc acggcaatgt
    10561 actgtccatg cttgcgccgg ctgtactggt gtattatctg cggaaagctc tcctttccca
    10621 caccactctc tccggtaatc agtacagaca agtcggtggg cgctacctgg atagcgatat
    10681 caatggcacg catcagcgct tcattgttgc cgataatgcc gaaacgtaat tttacttgtt
    10741 gtatttccgc ttttgtcatt ctacaaatct tcttctacac tatcgagttt cagtttgtcg
    10801 ctatcgtcac gtttctcgta atattgcttg cgcagcggat ttgcatgtgc ctctttctca
    10861 cgctggcggt tacggaacac atctattgcc acatagatag cctgccggaa tgaatcttca
    10921 gaggcgattc ctttcccggc aatatcgtag gccgtgccat gagcaggcga agtgcgtatc
    10981 accggcaagc cggcagtata gttcacgccc tcgtccatag ccaatgcctt gaacggtgcc
    11041 agcccctggt cgtgatacat ggccaggata ccatcaaaat gggtaaagtt atctgagccc
    11101 ataaacccgt ctgccggata aggaccatag caaagcatac ccttagcagc catttcgttg
    11161 atggccggaa tgataatctc ctgctcttca gttcccagca atccgccgtc tcctgcatgc
    11221 ggattcagcg aaagcactgc aatacgcggt gcgctgatag caaaatcctg cttcaaggag
    11281 cggttgaata tcttcagttt ttcttgtatc agttctttgg tgatgcttcc ggctatctct
    11341 ttaacgggaa tatgtccggt caccaatgct acccggaagt catctttcat cagaatcata
    11401 agggccttct cgccatctcc caatttttgc tctatatact ccgtatgtcc ggggaaggca
    11461 aactcctccg actggatggt atgcttgttg atgggagctg tgacaatcac gtctatcatt
    11521 ccctccttat attcctcaat ggctttttcc agtgcaccaa gtgcagcttt accagcttca
    11581 acgtcaggtt tagagaactc aacctttact tcatcatccg tacagttcac tacactcaag
    11641 cgattgggaa ccgcttcgga ggcggagttg acgatactga agttggtagg caagtccaat
    11701 gatttacgat gataagctgc cactttaggc gaaccgtaga taatcggcgt gcacaattcc
    11761 agcatcaccg ggtctgcaaa cgtctttaaa atcacttcat accctacacc attaatgtcg
    11821 ccttgtgtaa tgccgactct tattttgttg tcttccattt ttattactta ttattagtag
    11881 tatcttttga ggttacgcct accggaattt ccgtaccttc ctgcttgctg ccgggcagtt
    11941 tcaaggtata gagcgaagcc tccatctgac gtaccagatt acgtttcatt ttatcaggtg
    12001 aataaataaa tatttcagat acgataatac gctgattggc cttgtccaaa cgtacatgcg
    12061 atacgaacgg accgcccatg aagtcaccct ttatgcgcca caagccgcgg gcctccagtg
    12121 catagtctcc ctgcacactg atggggcgta catcggtcat cagagaatcc gtcgacatat
    12181 acatgccttc acgggcacca gggatattaa ccttcatcac ggaatcgcgt ttatgaacaa
    12241 aatattcttt agtaaacgta tccttatccg tataaggata agagtagatt acaaagttct
    12301 ggtcgccggt agctgcattc gtacctgccc agaagaagtt ctcaccctcc ttggtagatg
    12361 tcagttcgcc cggcacccat acatcgcaat cgaactggct tttcaccttc gttgctatat
    12421 agtcgctatg cttgtccttc aatactgaaa tctgacgatt catttccgca tgggtaaaga
    12481 aatcgatgat tacctgcctg ttctcctcca caaatttctc gaacgaagcc tcgtccggtg
    12541 cctgaatagt gagaatagac tgaggagcag catatacatt ccttgcatac ttgaatttag
    12601 gctgggtata gaggtccttg ttcacatcga caataatgat attgcgaatc agttttaaag
    12661 tggcatcata attggaaggg gcagtataca tgattcggaa tgaacgttct gactggggaa
    12721 gccccggaac atcagaatca agcacatcga aaagcgccct accggcagga cgttcccaca
    12781 agccgggctc caccactacc agaacttcat acgcacgacc gctggaggtc ggagtaaaca
    12841 cacccttttt accaccaccg caagcggaaa aaagtgtcag tacgagaacc atacttaaat
    12901 aaaacaagtg ctttctcata tctctatcat tttagttttt cacaaagcta cgaagaatgc
    12961 gtaatatcct ccctacctaa gttaataatt tatattaatt cttctttatt ctcctcctgc
    13021 ttggcagtgg acaacatgcc acaagcggca aatatatcct ctccacgcga tgaccgtata
    13081 gtggtaaaca gaccgtgcga agtcagataa tcacggaacg cagtcatggt ttccatatca
    13141 gccccttcaa gattcactcc aggtatggca tgaaaacgaa tcaggttaat ccggcagtcc
    13201 agcccgcgta gcaacttcag aagttccttt gcatacggta acgagtcatt cactcctttg
    13261 aaaacaatat attcaaaaga tagtctgcgc tgtttgctaa aatcatagtt tcttaacaat
    13321 tcaacaatct ccgtgatgga gaaggccttc tctgccggca tcagctcgcg acgttgcaaa
    13381 ggtatcggcg aatgaaggct gatagccaga tggcagtccg actcctcaat aaaacgctgc
    13441 aagcccttct tcaatcccac agaagaaagt gtaacacgct tgggactcca cgcataccca
    13501 tatgaggcgg tcattatttc cagcgctttc aatacctcgt ccagattatc aagtggttca
    13561 cccatgccca tcattaccac attggtaagc ttgtcccttt cgggcaacga attgatttga
    13621 ttaataatct ggttggatgt cagattggca gtaaaacctt gtttgccggt catacagaac
    13681 ttgcaattca tcttacagcc cacctgcgag gagacacaaa gcgtagccct gtcttcgtcg
    13741 ggtatataga cagcttccac gaaatgcccc tctcctgccc gatacaagta tttcaccgta
    13801 ccgtctacag agcgcatggc atctaccggt gcttcggcac ctacctcata gatttctttc
    13861 agcaattccc gatgctttaa cgaaagattg ctcatttcgt ctatagaagt caccttcttg
    13921 ccatacagcc aggaagctat ctgcttggca gagaaaccgg gcattcccag attcttcacc
    13981 acattctgca attcagagag cgtcaagccc aatagaggtc gtttctgcat atcgtttttc
    14041 attaaaaaca aaactctttc aagaatgcaa aggtaggaat aaagttgcac aaagacaacg
    14101 gagagtatag aaaatgaaat gtacagagaa tgaaaaagcc gcccgggagt accggacggc
    14161 ttttcaatat gggttttcta ttcttagaag aataaataac gttggtcttt tacgttggct
    14221 ttcagataca agtcactgat gaactggctt gccatgcgtg cgtgcatgtt agccaagtta
    14281 gcctcttcag tttccttgtt gaatgtttcg ttcaatttct cttttgcata aggttgcaga
    14341 acgaatacac caccattacc cttgatagga gcactcagct tgttcacttc ggcaatagaa
    14401 gcgtatgcgc ctaccagagg ttcgctgcta cgcaatgccg ggatataggc aggagcagag
    14461 aaagtaacgt gctttacaga atcactgaca gcatttgcca tattcttgta ctgctcgaac
    14521 gaagttgcat tggcagcctt catatcagcc ataatcttct ctgctttctt gtcacggaga
    14581 atttcagctc tcaactggtc ctttaccaaa gccagtgggc gataaccttc aggaacaata
    14641 cttgcaacac ctactaccag catacggtcg ctctcgccac attcgtacaa accggaaact
    14701 tcaccggcct ttgcctcaaa cgcccatttc aaagcatctt tggtacctct gataccaccg
    14761 ataccatgtt cagagctgta caagtcggct ctatccaaca acttataacc ggcatcttcc
    14821 gcattggcaa tcattttctc taaagtattg tttgcagcga taaactggct gaattcattg
    14881 tatgccttgc tgtaagtttc cttactgaat tctaccggac gcttgataac ggctacctta
    14941 tatttatcct tgacagcctt cttgttggtt acctgcaaaa tgacatttgc ttgtcccaac
    15001 gccagattgg tcagttcgtt ctgtcccaaa gtagtgacag cagtaatata tttcaagttg
    15061 tcaccgtcaa tctgtgcgcc ttcgtagtta gctgaagaga tccaggtagg ctcaccggtc
    15121 tgaccgtact tcttcgcaat ttcagcaaag ctggcaccac ccttaatagc attgtagatg
    15181 ctgtcggcta aagtcttcgt cttttcagca tcttcggcaa ctacctgaat ctgacggaac
    15241 tcgatagagt ccggcatagc agcagtagcc aatttcttga aagagttaag agtattgtcc
    15301 gatacgttat aataaggtcc gaatacacca cccaccgcaa cagagtccaa acgggctgtc
    15361 acatcagcag gcagagactt agtagtgtag aacaagtctg tataaggagc ttcggaaccg
    15421 gtagaacgga taaaggtagt atagtcagaa ggattggcag taagttgttc agtgtattct
    15481 tccatttcct tctggagagc agctctgtct tctgcacttg cagtaacttg cacatcaatg
    15541 aacttgatat tgcgagtttc cacatattgc ttgaactgtt ctttcttctt gtcgtatgca
    15601 gccttcaaat cagaatcctt gataacgatg gtagagtcaa cgatagaaga atagggaact
    15661 gcagcaagca gcaggtctga ctgctctact cttgcatcaa aagcgtcctg agcttctacc
    15721 gggttggaga aaagggattt tgtaatcaaa gcttgatact tctcctgaag acgtgcctgg
    15781 ataagggact tttcgaggaa agaccagaac ttgtacatgg attcatagta ttctgcatat
    15841 tgtgaaggca tctgtgcctt attcattttt gaatagtcca ccaagaactt cttcaacata
    15901 tccttatcaa acgcaccggt ctgaggatta cggaacggag tctgttgcag catcggatgc
    15961 acaccggcat taatgatagc ctgaatctca gccttcgata caaccagacc gagtttcttt
    16021 gcttcctttt caatcagctt attattgacg tatgttctcc atacttcatc tttgatttgg
    16081 tttgtctgct catcgctcaa tgcactgttg ccactggaga acttgatgac ttctgtatat
    16141 tcttctacca atgcttgaaa atcctgagcg gaaattgatt ccccgttcac ttcacctacg
    16201 tcttgtgact ggtgtggctg aagcactttc cacgcgtcac ctgcgatgaa agcaaacagc
    16261 g
//
