LOCUS       c00022_gnlPro..        11300 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|PFFMJECB_22.
ACCESSION   c00022_gnlPro..
VERSION     c00022_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-07 06:28:36
            Original ID  :: gnl|Prokka|PFFMJECB_22
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 11300
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             complement(1..246)
                     /locus_tag="ctg22_1"
                     /transl_table=11
                     /translation="MNWMIYPAARAFIKVCAVLFGAGAAAAVLIHLFMPFFLRSPRTAA
                     PFLLLGTGAELLSILSLSFLMFWGARVLLASRGSRIT"
     protocluster    1..11300
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[364:7481]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      365..7481
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..11300
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..11300
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             complement(365..1207)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: AcetylCoA_hyd_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg22_2"
                     /sec_met_domain="AcetylCoA_hyd_C (E-value: 8.8e-35,
                     bitscore: 109.8, seeds: 181, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VGVVETNWPDEARSFAAADPLTDKIGQNVADFLAADMKRGIIPST
                     FLPLQSGVGNIANAVLGALGRDKTIPAFEMYTEVIQNSVIGLIREGRVKFGSACSLTVT
                     NDCLEGIYRDMDFFRDKLVLRPSEISNSPEVIRRLGVISINTAIEADIYGNVNSTHIGG
                     TKMMNGIGGSGDFTRNAYISIFTCPSVAKDGKISAXXXXIIITEQGVADLRGKSPKERA
                     QTIIENCVHPDYKNILWDYLKLSDGKAQTPQSIRAALGMHAELARSGDMKNVDWAQYK"
     CDS             complement(1194..1844)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: AcetylCoA_hydro"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg22_3"
                     /sec_met_domain="AcetylCoA_hydro (E-value: 7.2e-44,
                     bitscore: 140.0, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSYKVLTPEEAASLIKHGHHIGLSGFTPAGTAKAVTAALAKIAEA
                     EHEKGNPFQVSVFTGASTGDSCDGILSRAKAIRYRAPYTTNVDFRKAVNNGEIAYNDIH
                     LSQMAQEVRYGFMGNVDIAIIEACEVTADGKIYLTAAGGIAPTICRLADKIIVELNAAH
                     SKSAMGLHDVYEPLDPPYRREISIFKPSDRIGKPYIQVDPKKIVXXXXDCGRC"
     CDS             complement(1906..2685)
                     /locus_tag="ctg22_4"
                     /transl_table=11
                     /translation="MNSAASFSTPPEEEGPCGDWTYHEWAEAFSTNDLARALPPGHIAV
                     CRVQTGGRGRFNRKWIGEEGGLWASFTVPLSAPEDTAAGVHWGHLPLVAGLALFNMLCG
                     MGLDSVRLRWPNDLLAGKSKLAGILVERPAENMAVIGIGINVFNDVSSIAGEIKDPPAR
                     LADLVRDCPSLHAVMASLGSHLNQVLSVFSHGGVPSLQEGLSRAWAGERPVSILTDDET
                     VRGIFTGIDDQGNPVLSLPAGTVRTIPAHLINRLLEE"
     CDS             complement(2723..4348)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg22_5"
                     /sec_met_domain="OAD_beta (E-value: 1.5e-159, bitscore:
                     520.4, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGVFSLSWQMVGMWGIAIFLLYLGVAKQYEPLLMVPIAFGALIAN
                     IPDNGMLITQLNQQVISSNEQGEVTATPLNNVGYLRVHVAPLQQAPSKVPANLTTPESR
                     AQYQEIMQQPMQVYPGSQLTVSKIKSVRESQEKAKADAARLGDDSLTVDPNLMDFQNVT
                     RDNGNEPVFLLTNGEGTTVVRQQGVNYFDTSGNRIPVDLKTQKLEPLVVSAAGKYVAVG
                     QHTQELLVTSIHGGLYDWIGLGIKAEIFPPIIFLGVGALTDFGPLLAAPRTLLLGAAAQ
                     VGVAATFFMALFMGFTPNESASIGIIGGADGPTSIFLTMKLAPHLLGAVAVAAYTYMSL
                     VPLIQPPIMALLTTKKERLIRMKSLRTVSKSEKLFFAVLVTIVTILLIPDASPLIGMLM
                     LGNFLRECKVTERLVQASQNEIINIVTIFLGTSVGLTMQGDRFLQSETLLIILLGIVAF
                     GVATAGGVIAAKIMNLIWRKNPVNPLIGSAGVSAVPMAARVSHNVGQKYDPSNYLLMHA
                     MGPNVAGVIGTAVIAGYYIATLAK"
     CDS             complement(4466..4867)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 58.8; E-value:
                     1.2e-18)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg22_6"
                     /sec_met_domain="Biotin_lipoyl (E-value: 2.8e-19, bitscore:
                     58.8, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKLRITVDGKVFDVSVELLDQVSSTTAAPAPAPVAAPAPAASAP
                     VAAPAPAPAPAPAPAAAGAGDVPSPLAGKVVSLDVAAGAPVKAGDQILTLEAMKMNTII
                     YAPASGTLTAFCVNPGDTVQEGQALAKIG"
     CDS             complement(4940..5392)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg22_7"
                     /sec_met_domain="OAD_gamma (E-value: 3.2e-10, bitscore:
                     30.5, seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLLTTLAFAFAQGIANVMDNLNYQVVGIMVVMLCLGGMAVILTVS
                     GSIAAAIQNRAKAKTAAPVAVPAAAPAAAGKPGMTPEMLAILSAAVDSAMTELTPEMVA
                     VISAAVDAGLDGMSHRIVEIKQSPGSGYAAAGRAEIFASHRIRPSR"
     CDS             complement(5414..6979)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Vparvula"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg22_8"
                     /sec_met_domain="CT_Vparvula (E-value: 3.5e-217, bitscore:
                     711.6, seeds: 132, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAIDPKLIDDLNSRRKKVILSGGQEKIDKRHEKGEMTARDRMGYL
                     FEEGTFSEIGMHVRHNCHNFGMGKKEIPGDGVVSGFGLVDGRPVACAASDFLAQGGSLG
                     DMHAMKIADAQKYALKAGIPMVTVNDSGGARLQEGVAALSGYAQVFYNNVLASGVVPQI
                     SMILGPCAGGAAYSPALTDFIIMRNSGNAGMYITGPKVIEQVTYEKCTMDDIGSAAIHA
                     TVSGNVHFVADSDAHAMDILKRLLSFLPSNNTEEPPHKLDTPLDLSADEGMSDLIPGDN
                     RTPLDVQPIISRLVDNGDFLEVHKDFAKNVVVGFGRICGVVVGIIANQPNVKAGCLDID
                     SSDKAARFIRFCNAFNIPLVNLVDVPGFLPGKNQERGGIIRHGAKLIFAYSQATVPKVT
                     LIMRKAYGGAYIAMCCKDLGADAVFAWPGAEIAVMGAEGAVPVLYGRELKAVEDPAEKA
                     KRQGELLEEYREAFYNPYVAAGMGQITEVINPEETRAKIAFALRTLLNKKEVRPAKKHG
                     NIPL"
     CDS             complement(7011..7481)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Glyoxalase_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg22_9"
                     /sec_met_domain="Glyoxalase_4 (E-value: 1e-25, bitscore:
                     80.1, seeds: 51, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYCRPPPCIPYNHHTHMIQQIDHIGIAVKSLDATVPYYRDALGLG
                     EPHIEEVPTQKVRVAMFDVAGVHIELLEPTSPESAIAKAIEKKGEGIHHIAFKTNDIAG
                     NISQAKEAGLTVLNDPPVPGAHNTQVTFLHPKCTFGVLTEFCQHPGGCECGK"
     CDS             7599..8333
                     /locus_tag="ctg22_10"
                     /transl_table=11
                     /translation="MFKSGLAVLFLLASWFSAACAYELLPAHVAVVYNGKSELSRRMAR
                     EYARVRGVPEGNLVSLDCPMTSEISRKEYEDTIRVPLLETARKQRWWVPSGIASSPLMN
                     RKIFVLVLMADLPMKIRHETPAPLPGKGVNQMQTDRAAVDSELALLAVGGYERKSWQVN
                     PYFNKREDFVGSGLPSFLVCRLDGLTPDTCMRLVAEPAXXXXKRFMGVGRCGPGRSLCP
                     GGPVAGRRVRAREGGGHSRLSG"
     CDS             8287..9138
                     /locus_tag="ctg22_11"
                     /transl_table=11
                     /translation="VFERVREAGIPAYLDDWPQTLPEKFPLSRDTALYCGWYAGKANGP
                     FSDPSFRFRPGAIAMHLHSFSAADFKVPGRGWSSALLEKGAAVTVGNVYEPFLGACHRF
                     DIFVDRLLDGYTVAEASWMSMPVLSWQGVVFGDPLYRPYARMKDMDVEPTEEDRYFQGW
                     WASSVQFGDRWKDRSARLMESARKAPFSCLYEALALECLYRKEPVRAGDLLSSALDGAA
                     DARTRARLLLEILMAERARGGNKAFLQRADGIRGLMSSSAFLPALEEWLARVTPPPAPP
                     KK"
     CDS             9248..9595
                     /locus_tag="ctg22_12"
                     /transl_table=11
                     /translation="MNIINKIEQEQLKADVTPFNVGDTIKVHTRVIEGGKERIQIFQGI
                     VIAKRGSGINEAFTVRKISYGEGVERVFPLHTPRIAKIEVVNRGKVRRAKLHYLRGRIG
                     KDAMIVKSANR"
     CDS             complement(9711..9917)
                     /locus_tag="ctg22_13"
                     /transl_table=11
                     /translation="MECHALSSWFGFAYEIFRFLLHSPEAIQARTEENPKNVFAPDRKQ
                     PPLSTFPTPEKRSHPHMAPGEIS"
     CDS             complement(10029..11300)
                     /locus_tag="ctg22_14"
                     /transl_table=11
                     /translation="HGGITPKLICLREDGGDALLLPINIYPAQPPVDMGDFASPEWVTG
                     AETTFTPGMDIYALGLALYILLTRKTPMEAGFAMPSSLIKCSDAVDSAVSRAINPDTRE
                     RYRDLGDFITDLDKAIANPAGRNAASIPPPPSSPAIPALNMQKGQSNIYYYLIPALIVG
                     IVLTYTCILYKKDVVRMRNDYNEQVQKENNAKAEAARQANRDARRHAPATAQNAATAIP
                     SPVPSARPAQAPAVPKVSAEPGKVNWSLQPGVKVRQSSNRNMLGAYGPEKAVDGNTSSR
                     ISDVSISATGVVEGKTAWFGIDFGRETNRTIEKVVIYTPANLTLLGTMEKFKVILYGND
                     KNVLAEKTFSTTPSEKSTNVTSWKLDAPVKARALRVESANPSQPLALTEYEGRFGGLQT
                     GXXXVEAYGPEDAEDTPAPAPAEK"
ORIGIN
        1 tgttattctg cttccgcggg aggccagcag gactctggcg ccccagaaca tgaggaagga
       61 cagggaaagg atggagagca attccgcccc tgtgcccaaa agcaggaagg gtgcggctgt
      121 ccggggagag cggaggaaaa aaggcatgaa cagatggatg aggactgccg ctgctgcgcc
      181 cgcgccgaaa agaacggcgc agactttgat gaaagccctg gctgctgggt aaatcatcca
      241 gttcatggtg aagagaagga gtagagggga tgggaaaaag gaaaaggacc gctccctttg
      301 cggaagcggt cctgaggggt taacgtgaat tcatggatgc caatgcgaat gacggcatgc
      361 ggaattactt atactgggcc cagtcgacat tcttcatgtc tccgcttctg gccagttcgg
      421 cgtgcatgcc caaagcggcc ctgatggatt gcggtgtctg ggctttgccg tcggacagct
      481 tcaggtaatc ccagaggatg tttttgtaat ccgggtggac gcagttttca ataatggtct
      541 gggcccgttc tttcgggctc ttgccgcgca ggtccgcgac cccctgctcg gtaataatga
      601 tatnnnnnnn nnnggcgctg atcttgccgt ccttggcaac ggacgggcag gtgaaaatgg
      661 agatgtaggc gttgcgcgtg aagtcgccgg acccgccgat gccgttcatc atcttcgtgc
      721 cgccaatgtg cgtggagttg acgttcccgt aaatgtcggc ttcaatggcg gtgttgatgg
      781 agatgacgcc gagacggcgg ataacttccg ggctgttgga tatttccgag ggacggagca
      841 ccagtttgtc gcggaaaaag tccatatccc tgtaaatgcc ttccaggcag tcgttcgtca
      901 cggtcaggga gcaggcgctg ccgaatttca cgcggccctc ccgaatcagg ccgatgacgg
      961 aattctggat gacttccgtg tacatctcga acgcgggaat cgtcttgtcg cggcccaggg
     1021 cgcccagcac cgcgtttgcg atgtttccta cgccggactg gagaggcagg aacgtggagg
     1081 gaatgatgcc ccgtttcatg tcggcagcca ggaaatcggc cacgttctgc ccgattttat
     1141 cggtcagggg atccgctgcg gcgaaggaac gggcttcatc cggccagttg gtttcaacaa
     1201 cgcccacaat cttnnnnnnn nnncacaatc tttttcgggt caacctggat gtacggcttg
     1261 ccgatgcggt cgctgggttt gaagatggaa atttcgcggc ggtagggagg atccaggggt
     1321 tcgtaaacgt cgtgcaggcc catggcgctc ttgctgtggg cggcgtttaa ttccacgata
     1381 attttgtctg ccaggcggca gatggtggga gcgatcccgc ccgcggccgt caggtaaatt
     1441 ttgccgtcgg ccgtgacttc acaggcttca ataatggcga tgtccacgtt gcccatgaac
     1501 ccgtagcgca cttcctgggc catctgggac aaatggatgt cattataggc gatttccccg
     1561 ttgttcaccg ccttgcggaa atcaacgttg gtggtgtagg gagcgcggta gcggattgcc
     1621 ttggcccggg aaaggatccc gtcgcaggaa tcgccggtgg aagcaccggt gaagacgctc
     1681 acctggaaag ggttcccctt ctcatgttcc gcttctgcga tttttgccag cgcagccgta
     1741 acggccttgg ccgttccggc gggcgtgaat ccgctcagcc caatatggtg gccatgcttg
     1801 atcaggcttg ctgcttcttc tggtgtcagt accttgtaac tcatgtcagt gatttttgtt
     1861 ggatgaaaaa agaaagaaac cccgtgtaaa aacggagcgg caggctcatt cttcgaggag
     1921 cctgttgatc aggtgcgccg gaatggtgcg gacggtgccg gccggaaggg atagcacagg
     1981 attgccctga tcgtcaatcc ctgtaaaaat gccccggacg gtttcgtcat ccgtaagaat
     2041 ggaaaccggc ctttctccgg cccatgcccg ggacagcccc tcctgaaggg aggggacgcc
     2101 gccgtgggaa aagacggaaa gaacctggtt caaatgactg cccagggaag ccatgacggc
     2161 gtgcagggaa gggcagtccc gaacaagatc cgccagcctt gccggagggt ccttgatttc
     2221 cccggcgatg gaggatacat cattgaaaac attgatgccg atgccgatga cggccatgtt
     2281 ctccgccggg cgttccacca gtattcccgc cagtttggat ttgcccgcca gcaggtcgtt
     2341 cggccagcgc aggcgcacgg aatccagccc catgccgcag agcatgttga acagggccag
     2401 ccccgcaacc aggggcaaat gtccccagtg cacgccggcc gctgtatcct caggagcgga
     2461 cagggggacg gtgaaggatg cccacaggcc gccttcctcc cctatccatt tgcggttgaa
     2521 cctgccgcgg cctcctgtct gaacgcggca gacggcaata tgccccgggg ggagggcgcg
     2581 ggccagatca ttggtggaaa aagcctcggc ccattcatga taagtccagt cgccgcatgg
     2641 tccttcctcc tccggagggg tggaaaatga ggctgcggaa ttcatgggac gggccgaggc
     2701 cggtagtaat tttcaattct gtttatttcg ccagagtggc gatgtagtag cccgcgatga
     2761 ctgcggtgcc gatcacgcct gcaacgttcg ggcccatggc gtgcatgagc aggtagttgg
     2821 aggggtcgta cttctggccc acattgtggg agacgcgggc tgccatcggg acggcggaga
     2881 cgcctgcgga cccgatcagg gggttgaccg gattcttgcg ccagatgagg ttcataatct
     2941 tggcggcaat cactccgccc gctgttgcca cgccgaaggc gacgataccc agaaggatga
     3001 tcagcagcgt ttccgactgc aggaagcggt cgccctgcat cgtgagcccc acggaggttc
     3061 ccaggaagat ggtgacgatg ttgatgattt cattctggga ggcctgaacc aggcgttccg
     3121 tcaccttgca ttcgcgcagg aagttgccaa gcatcagcat gccgatcagc ggggatgcgt
     3181 ccggaatcag caaaatggtg acaatggtta ccagcacggc gaaaaacagt ttttcgctct
     3241 tgctgaccgt tcgcagggat ttcatgcgga tcaggcgttc cttcttggtc gtcagcaacg
     3301 ccatgatggg cggctgtatc agcggaacca gggacatgta cgtgtatgcg gccacggcca
     3361 cggcgcccag caggtgcggg gccagcttca tcgtcaggaa gatggaggtg gggccgtcag
     3421 cgccgccaat gatgccgatg gacgcggatt cattcggggt gaaccccatg aacagggcca
     3481 tgaagaacgt ggcggctacg cccacctggg ccgctgcgcc cagaagcagg gtgcgcggag
     3541 cggcaagcag cgggccgaag tccgtcaggg ctcctacgcc cagaaagatg atgggcggga
     3601 aaatttcagc cttgatgccc agcccgatcc agtcatacag gcccccgtgg atggaggtga
     3661 ccagcagttc ctgggtatgc tggcctacgg ccacgtattt gcctgcggcg gaaaccacca
     3721 ggggctccag cttctgggtt ttcagatcca ccggaatccg gttgccgctg gtgtcaaagt
     3781 aattgacgcc ctgctggcgg acgacggtgg tcccttctcc gttcgtgagc aggaagaccg
     3841 gttcattgcc gttgtctctc gtcacgttct ggaaatccat caggttgggg tccaccgtca
     3901 ggctgtcgtc gcccaggcgg gccgcgtcag cttttgcttt ttcctgggat tcccgcacgg
     3961 acttgatctt ggaaacggtc agctggctgc cggggtaaac ctgcatgggc tgctgcatga
     4021 tttcctgata ctgggcacgg gattcaggcg tggtcagatt ggccggcacc ttggagggag
     4081 cctgctgaag cggagccacg tgaacgcgca ggtaccccac gttgttcagg ggcgtagcgg
     4141 ttacttcccc ctgttcattg gaggagatga cctgctggtt cagctgggtg atgagcattc
     4201 cgttatccgg aatgttggca atgagggcgc cgaaagcaat gggaaccatc aggagcggtt
     4261 cgtattgctt ggctacaccc agatacagga ggaaaatggc aatgccccac atccctacca
     4321 tctgccatga tagggagaag acgcccatcc cctgtaaaaa ggtgattaat gaatcaaaaa
     4381 gactcatagg gaatattttt gtagcggttt attatctgag ccggagcccg ggactgttgg
     4441 cgtttccggg ctgccgccgc cgggattaac caattttggc cagtgcctgt ccttcctgaa
     4501 ccgtgtcgcc cgggttcacg cagaaagcgg tgagcgtgcc ggaggcggga gcgtagatga
     4561 tggtgttcat cttcatggct tccagcgtca gaatctggtc accggccttc acgggtgcgc
     4621 ctgctgccac gtccagggag acgaccttcc cggcaagcgg gctgggaacg tctcctgcgc
     4681 cggcggcggc cggagccggc gcaggtgcgg gagccggggc cggggcggcc acgggggcgg
     4741 aagccgcagg agcgggagcg gccacaggtg cgggggccgg agccgcagtg gtggaggaca
     4801 cctggtccag aagttctacg gatacgtcaa atactttgcc gtctacggtg atgcgaagtt
     4861 tcttcataat agtgtgtggt atgggatatt aagttaaatg attccgcctg ggcggggtaa
     4921 gggtgaataa tgcagtagtt cagcgggaag gcctgatgcg gtgggaggcg aaaatctccg
     4981 ccctgcccgc ggccgcatag ccggaacccg gggattgctt gatttccacg atgcggtggc
     5041 tcatgccgtc caggcctgcg tccacggcgg cggagatgac ggccaccatt tccggagtaa
     5101 gctccgtcat ggcggaatcc acggcggcgg aaaggatggc gagcatttcc ggagtcatgc
     5161 ccggtttgcc cgccgcagcg ggagcggcgg caggcacggc tacgggagca gcggttttgg
     5221 ctttggccct gttctgaatg gcggcggcga tggagccgct gacggtcaga atgacggcca
     5281 tgcctcccag gcacagcata accaccatga tgccgacaac ctgatagttc agattgtcca
     5341 taacgttggc gatgccctgt gcgaaggcaa aagcgagtgt tgtaagtaac atatgaatcc
     5401 gttgggatgg atgttagagc ggaatgttgc cgtgtttctt ggccgggcgc acttccttct
     5461 tgttcagcag ggtgcgcagg gcgaaggcga ttttggcgcg ggtttcttcc ggattgatga
     5521 cttccgtgat ctgtcccatg ccggccgcca catacgggtt gtaaaaggct tcccggtatt
     5581 cttccagaag ttctccctgg cgcttggctt tttccgccgg gtcttccaca gccttcagtt
     5641 cgcggccgta gagtaccggg acggcgcctt ccgcgcccat aacggcaatt tccgcaccag
     5701 gccaggcgaa gacggcgtca gcgcccaggt ccttgcagca catggcgatg taggcgccgc
     5761 cgtaggcttt ccgcatgatc agggtgactt tgggcaccgt ggcctgggaa taggcgaaga
     5821 taagtttggc gccgtggcgg ataatgccgc cccgttcctg gttcttgccg ggcaggaagc
     5881 cgggcacgtc caccaggttc accaacggaa tattgaacgc gttgcagaaa cggatgaagc
     5941 gcgcggcctt gtcggaggag tcgatatcca ggcagccggc tttcacattg ggctggttgg
     6001 cgatgatgcc gaccaccacg ccgcagatgc ggccgaatcc gacgacgaca tttttggcga
     6061 agtccttgtg tacttccagg aagtccccgt tgtccaccag acggctgatg atgggctgga
     6121 cgtccagcgg cgtgcggttg tcgccgggaa tcaggtcgct catgccttcg tcagcgctca
     6181 ggtccagcgg agtgtccagt ttgtggggcg gttcttccgt gttgttggaa ggaaggaagg
     6241 aaagaagcct cttcaggatg tccatggcgt gcgcgtcgct gtccgctacg aaatggacgt
     6301 tgccggacac ggtggcgtga atggcggcgg agccaatgtc gtccatcgtg catttttcat
     6361 acgtgacctg ttcaatcact ttgggaccag tgatgtacat gcccgcgttg ccggaattgc
     6421 gcatgatgat gaagtccgtc agggcggggg agtaggccgc gccgcccgcg caggggccca
     6481 ggatcatgga gatttgcgga accacgccgg aggcaagcac gttgttgtaa aacacctggg
     6541 cgtatccgga aagggccgcc actccttcct ggaggcgcgc gccgccggag tcgttcacgg
     6601 tcaccatcgg gatgccggct ttcagagcat acttctgagc atccgcaatt ttcatggcgt
     6661 gcatgtcgcc gagggaaccg ccctgggcca ggaaatcgga ggccgcgcag gctaccgggc
     6721 ggccgtccac caggccgaaa ccggaaacga cgccgtcgcc ggggatttcc ttcttaccca
     6781 tgccgaagtt gtggcagttg tggcgcacat gcatgccgat ttccgagaag gtgccttcct
     6841 caaagaggta ccccatgcgg tcgcgggctg tcatttcgcc cttttcatgt ctcttgtcga
     6901 tcttttcctg accgccgctg aggatgacct tcttgcgacg gctgttcaga tcgtcaatca
     6961 atttgggatc aatagccatt ggtctagtgg tatggtgaat agggagaatg ttacttgccg
     7021 cattcgcagc cgccggggtg ctggcagaat tcggtcagga cgccgaaggt gcacttggga
     7081 tgcaggaagg tgacctgcgt gttgtgagcg ccggggacgg gcgggtcgtt cagcacggta
     7141 aggcctgctt ccttggcctg ggagatattt ccggcgatgt cattggtctt gaaagcgatg
     7201 tggtggatgc cttccccttt tttctcaata gccttggcga tagcgctttc cggagaggtg
     7261 ggttcgagca gttcgatgtg gactccggca acgtcaaaca tggcgacgcg gaccttttga
     7321 gtgggaactt cctcaatgtg gggctctccg agcccgagcg catcgcggta ataggggacg
     7381 gtggcgtcaa ggctcttgac ggcgatgccg atatggtcaa tttgctgaat catatgcgtg
     7441 tgatggttat agggaatgca ggggggaggc ctgcaataca tcaagagtta ttaaagcgta
     7501 tttttttagg atgtgaagcg aaaagcggaa aaatggcgaa ttcgtggccg tccctttcac
     7561 ctgcttgatt gccccggaag atgaggtatg gtaggggcat gttcaagagt ggattagccg
     7621 tgttatttct gctggcgtcg tggttttccg ccgcgtgtgc ctatgagctg ctgcccgctc
     7681 atgtggccgt ggtttataac ggaaaatccg agctgagccg ccgcatggcc agggagtatg
     7741 cgcgggtgcg cggcgttccg gaagggaatc tcgtttccct ggattgcccc atgaccagcg
     7801 agatttcgcg gaaggaatat gaggatacga tccgcgtccc gctgctggag acggcgcgga
     7861 aacaacggtg gtgggtgcct tccggcattg cgtcctcccc cttgatgaac cggaagattt
     7921 ttgtgctggt gctgatggcg gacctgccga tgaagatacg gcatgaaacg cccgctcccc
     7981 ttcccgggaa aggcgtcaac cagatgcaga cggatcgcgc tgcggtggat tccgaactgg
     8041 ctctgctggc ggtgggcggt tatgaaagga agtcctggca ggtgaatccc tattttaata
     8101 aaagggagga ttttgtgggt tccggccttc cttcgtttct ggtatgccgc ctggacggac
     8161 tgacgcccga tacctgcatg cggctggtgg cggaaccggc gnnnnnnnnn naaaaaaggt
     8221 ttatgggggt gggccgttgt ggaccggggc ggtccctatg cccaggggga ccggtggctg
     8281 gacgacgtgt tcgagcgcgt gagggaggcg ggcattcccg cttatctgga tgactggccc
     8341 cagaccctgc cggaaaaatt ccccttgagc cgggatacgg ctctttactg cgggtggtat
     8401 gcggggaagg cgaacggacc gttttcggat ccttcgttcc gcttccggcc cggggcgata
     8461 gccatgcatc tgcattcctt cagcgccgcc gatttcaagg tccccggcag ggggtggagt
     8521 tccgccctgc tggagaaggg ggctgctgtg acagtgggaa atgtgtatga gccgttcctg
     8581 ggcgcctgcc accgctttga tatttttgtg gaccgcctcc tggacggcta taccgtggcg
     8641 gaggcttcct ggatgagcat gcctgtgctg tcctggcagg gggtggtgtt cggagacccc
     8701 ctgtaccgtc catacgcccg catgaaggat atggacgtgg agccgacgga agaagaccgt
     8761 tatttccagg ggtggtgggc ttcctccgtg cagttcggag accgctggaa ggaccgttcc
     8821 gcgcgtttga tggagtccgc ccggaaggcc cctttttcct gcctttatga agctctggcg
     8881 ctggaatgcc tgtaccggaa ggaaccggtc cgcgccggag atctcctttc ctccgccctg
     8941 gacggcgcgg ctgacgcccg cacccgcgcg cgcctgctgc tggaaatcct gatggcggaa
     9001 cgggcccggg gcggcaacaa ggcctttctg cagcgggcgg acggcatccg gggcctcatg
     9061 tcttcctccg cttttcttcc tgcgctggag gaatggcttg ccagggtgac tccgccgccg
     9121 gccccgccga aaaaataaat taaggacgta cggcaaattt ggattgcctt ttaggggatt
     9181 atggctcata ttctgcgtcc cgtaagtttt ccttttactg atattcacca gcaatagata
     9241 acacaagatg aacattatca acaaaatcga gcaagagcaa ctcaaggcgg atgtgacccc
     9301 atttaacgta ggtgatacca tcaaggttca cactcgtgtt attgaaggcg gcaaggaacg
     9361 tatccagatt ttccagggca ttgtgatcgc caagcgcggt tccggcatca atgaagcttt
     9421 caccgtccgc aaaatttcct acggtgaagg cgtggaacgc gtattccccc tgcatactcc
     9481 ccgcattgcc aagattgaag tcgtgaaccg cggcaaagtc cgccgcgcca aacttcacta
     9541 tctgcgcggc cgcatcggca aggatgccat gattgtgaag tctgccaacc ggtaatcgga
     9601 agaattgcta ttttgctggc ccggcccgcc gtgaggcggc gccgggtttt ttatttccgg
     9661 agtattgttt ttcctgaatg ggaaaggggt ccacagggac gacagccgct tcaggatatt
     9721 tccccgggag ccatatgggg atgagagcgt ttttccgggg tggggaaggt ggagaggggc
     9781 ggctgtttcc ggtccggcgc aaatacgttt ttcggatttt cctccgtccg ggcctggatg
     9841 gcttccggag aatggagcag aaaccggaaa atttcatacg cgaagccaaa ccaggaactt
     9901 agcgcgtgac attccatcag gccctgcccc aacctgcttt ccgggaaggg gaaaggaaac
     9961 ggcggttttc agcatggccc ccggaggggg gcgagcgggg gcgagcgggg gcagggcggc
    10021 gcggataatt atttttccgc aggtgcggga gccggtgtgt cctccgcatc ttccggtccg
    10081 tacgcttcca cnnnnnnnnn nccggtttgc aggccaccga accgtccctc atattccgtc
    10141 aacgccagcg gctgggaggg atttgcggat tccacgcgca gggcgcgcgc cttgaccgga
    10201 gcatccagtt tccaggaagt gacgttggtg gatttttccg aaggagtggt gctgaaggtt
    10261 ttttccgcca gcacgttttt gtcattgccg tagaggatta ccttgaattt ttccatggtg
    10321 cccagcagcg tcaggttggc cggcgtgtaa atgaccacct tttctatggt gcggttggtc
    10381 tccctgccga agtcaatgcc gaaccaggcg gtttttccct caaccacgcc tgtggcgctg
    10441 attgaaacgt cggaaatcct ggagctggta ttgccgtcaa cggccttttc cggaccgtaa
    10501 gctcccagca tgttgcggtt ggaactctgg cgaaccttga cgccgggttg aaggctccaa
    10561 ttgactttgc cgggttccgc ggaaactttg ggaactgccg gcgcctgcgc cggacgcgcg
    10621 gacggaacag gtgaaggaat ggccgtagcg gcgttttgcg cggtggctgg agcgtggcgg
    10681 cgcgcgtccc tgttcgcttg tcttgccgct tccgcttttg cgttattttc cttctgcacc
    10741 tgttcattat aatcattgcg cattctaacg acatccttct tatacaggat gcaggtatag
    10801 gtcagcacaa tgcccacgat cagggccgga atgagatagt aatagatgtt ggactgccct
    10861 ttttgcatgt tcagggccgg aatggccggg gaagatggcg gcggagggat ggaggccgca
    10921 tttcttcccg caggattggc aatggcttta tccagatccg tgatgaaatc ccccaggtcc
    10981 cggtagcgtt cccgggtatc cggattgatg gcgcgggaga ctgccgaatc cacggcatcg
    11041 ctgcatttga ttagtgagga gggcatggca aagcccgctt ccatcggcgt tttgcgggta
    11101 agcagaatgt aaagcgccag ccccagtgcg taaatatcca tgcccggcgt gaacgtggtt
    11161 tccgctccgg tgacccactc cggagaggcg aagtccccca tgtccaccgg aggttgggcg
    11221 ggataaatgt tgatgggcag cagcagggcg tctccgccgt cttcgcgcag gcaaatcagc
    11281 ttgggcgtga tgcccccgtg
//
