LOCUS       c00085_gnlPro..        11504 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|MAMIFLEI_85.
ACCESSION   c00085_gnlPro..
VERSION     c00085_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-07 09:35:58
            Original ID  :: gnl|Prokka|MAMIFLEI_85
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 11504
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..11504
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[7071:11503]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      7072..11503
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..11504
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..11504
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             complement(210..1553)
                     /locus_tag="ctg85_1"
                     /transl_table=11
                     /translation="MKKEYLIYKLSEDLKEATRIENELFRKFDVKRGLRNEDGTGVLVG
                     LTKIGNVVGYERIPGGGLKPIPGKLFYRGYDVDDLAHAIIKEKRFGFEEIAYLLLSGRL
                     PDKEELSSFRELINDNMPLEQKTKMNIIELEGNNIMNILARSVLEMYRFDPDADDTSRD
                     NLMRQSIELISKFPTIIAYAYNMLRHATHGRSLHIRHPQENLSIAENFLYMLKKDYTEL
                     DARTLDLLLVLQAEHGGGNNSTFTVRVTSSTGTDTYSSIAAGIGSLKGPLHGGANIQVA
                     DMFHHLQENIQDWTNVDEIDTYFTRMLNKEVYNKTGLIYGIGHAVYTISDPRAILLKEL
                     ARDLAREKGKEREFAFLELLEERAIDVFGRVKNNGKTVSSNVDFYSGFVYEMIGLPQEI
                     FTPLFAMARIVGWCAHRNEELNFEGKRIIRPAYKNVLDEVTYVPIKKR"
     CDS             complement(1566..2255)
                     /locus_tag="ctg85_2"
                     /transl_table=11
                     /translation="MGVTKVRFPETSSFGVKPVSREGTERLVRAACRYALEHHLPSVTL
                     VHKGNIMKFTEGGFKKWGYELAEREFGKELAEGRLVIKDCIADAFLQNTLLIPEEYSVI
                     ATLNLNGDYVSDQLAAMVGGIGIAPGANINYKTGHAIFEATHGTAPNIAGKDIVNPCSI
                     ILSAVMMLEYLGWKEAASLIENALEESFTEARATADLARFMPGSVSLSTSTFTREIVRR
                     IENGNNE"
     CDS             complement(2246..2734)
                     /locus_tag="ctg85_3"
                     /transl_table=11
                     /translation="MEKITVPFITGDGVGAEVTPSMQAVVNAAVKKSYGDRRGIEWKEV
                     LAGERAFHETGSWLPDETMEAFRTYKVGIKGPLTTPVGGGIRSLNVALRQTLDLYVCQR
                     PVRWYKGIVSPLKEPQKVDMCVFRENTEDIYAGIEXXXXXXXXXRLKSSIVFSVMTWG"
     CDS             complement(2738..4429)
                     /locus_tag="ctg85_4"
                     /transl_table=11
                     /translation="MTGMEWELKKPRLIGVHLKGKLSGWVAPKDVILKLAGILTVKGGT
                     NAIIEYFGPGTASLSATGKATICNMGAEVGATTSLFPYDERMGTYLKATGREEVAEMAA
                     SVAADLRADDEVLANPEKYYDRIIEIDLSLLEPYINGPFTPDAATPISKFAEVVITNNY
                     PRRMEVGLIGSCTNSSYQDLSRAASLARQVKEKNLKVASSLIVNPGSEQIRATAERDGM
                     IAAFEDIGATIMANACGPCIGQWKRHTDDPERKNSIVTSFNRNFAKRADGNPNTFAYVA
                     SPEITMALTIAGDLCFDPLRDTLVNAKGEVVKLSEPVGEELPAHGFIGGKEGYIAPGKG
                     QTEITVNPHSQRLQLLTPFPAWDGMDLLDMPLLIKVQGKCTTDHISMAGPWLRFRGHLE
                     NISDNMLMGAVNAFNGETNKVWNRSTNTYGTVSGTAKLYKSEGIPSMVVAEENYGEGSS
                     REHAAMEPRFLNVRVILAKSFARIHETNLKKQGMLALTFTDKADYDKIRERDLISVMGL
                     KDFAPGRTLKVVLHHEDGSKESFEVQHTYNEQQIAWFRAGSALNAR"
     CDS             complement(4368..4982)
                     /locus_tag="ctg85_5"
                     /transl_table=11
                     /translation="MVYDLTMLKTFYAAYSEKIERVRNVLRRPMTLAEKILYAHLYDGD
                     KVKNYRRGEDYVNFRPDRVAMQDATAQMALLQFMNAGREQVAVPSTVHCDHLIQAYKGA
                     KEDVATATKTNEEVYNFLRDVSSRYGIGFWQPGAGIIHQVVXXXXRISGWNDGRHGLSY
                     AQCRRFGHGGHWCGWCRCGGCDDRHGMGTEKAASDRRTLEG"
     CDS             5097..6155
                     /locus_tag="ctg85_6"
                     /transl_table=11
                     /translation="MITFATMKEQDSNSPIIHLQQQQVLLRMEYEYEKEEFKRQTENMG
                     VARKVKRGLCWYPATPGRSYYNSLNQLVIEITHTENTDIEHNFEFGRPVCFFRQSADGK
                     ITYMNFTATVSYADETRMVAIMPGAGAVMEVQETDNLGVQLYFDETSYRTMFEALEDTL
                     RSKGNRLAELRDILLGTSKAGFRELYPVRFPWLNSTQETAVNKVLCARDVAIVHGPPGT
                     GKTTTLVEAIYETLHREPQVLVCAQSNTAVDWISEKLVDRGVNVLRIGNPTRVNDKMLS
                     FTYERRFENHPLYPELWSIRKNLRELGSRARRGSYDEREGVRSRMSRLRXXXXXXHWKY
                     KSMQSFLMGHMS"
     CDS             6420..7010
                     /locus_tag="ctg85_7"
                     /transl_table=11
                     /translation="MHEEIMKFPSQWFYNGELEAAPEVRYRGILDWDTPIHWIDTSEMD
                     FKEEFVGETFGRINKAEADLLLSELKIYINRIGGNRILEEKIDIGIISPYKAQVQYLRS
                     KIKADASLKPYRSLFTVNTVDGFQGQERDVIFISLVRANEEGQIGFLNDLRRMNVAITR
                     ARMKLVILGEAETLKHHGFYRKLLEFIQNIGNQ"
     CDS             complement(7072..7683)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: IlvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg85_8"
                     /sec_met_domain="IlvN (E-value: 7.1e-13, bitscore: 38.2,
                     seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="IlvC (E-value: 1.1e-41, bitscore: 132.4,
                     seeds: 295, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVAPKGSGTSLRTMFLEGRGLNSSYAVYQDATGKAFDKTIALGIG
                     IGSGYLFETTFIREATSDLTGERGSLMGAIQGLLLAQYEVLRENGHTPSEAFNETVEEL
                     TQSLMPLFAKNGMDWMYANCSTTAQRGALDWMTPFHDAIKPVVQKLYASVKSGNEAQIS
                     IDSNSKPDYREKLNAELKALRESEMWQTAVTVRKLRPENN"
     CDS             complement(7700..8122)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg85_9"
                     /sec_met_domain="IlvN (E-value: 3e-16, bitscore: 49.2,
                     seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAQLNFGGVIENVMTREEFPLEXXXXXXXXXXXXXXXYGVQGPGQ
                     ACNLRDNGFNVIVGQRPGKTYEKAVADGWVPGETLFGIEEACQKGTIIMCLLSDAAVMS
                     VWPTIKPYLTAGKXXXXLLLSWFCYYLERPYRRGSS"
     CDS             complement(8173..8925)
                     /locus_tag="ctg85_10"
                     /transl_table=11
                     /translation="MMSENNKIGTYKFVAEPFHVDFTGRLTMGVLGNHLLNCAGFHASD
                     RGFGIATLNEDNYTWVLSRLAVELDEMPYQYEDFSIQTWVENVYRLFTDRNFAIIDKEG
                     KKIGYARSVWAMISMNTRKPADLLALHSGSIVDYVCDEPCPIEKPSRIKVASKEPVAAL
                     VAKYSDIDINGHVNSIRYIEHILDLFPIEMYKEKRIRRFEMAYVAESYYGDELTLFMDD
                     AGEGVYDVEVKKNGSEVVCRSKVIFTEK"
     CDS             complement(8922..9266)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg85_11"
                     /sec_met_domain="ALS_ss_C (E-value: 2.2e-20, bitscore:
                     62.6, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VLQAHYFTDDEIYQHEIALYKITTPTLEEKPEVSKVIRKYNARIV
                     EVNAVFAIVEKNGMSEEITNLYEELRQLDCVLQFVRSGRVAITTSCFERVNEYLADREA
                     KYRQSKHQES"
     CDS             complement(9517..11268)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg85_12"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.1e-47, bitscore:
                     151.4, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MADNNKKSNFSSLSQGEGRGEALITGAEALMRSLEHQGVKTIFGY
                     PGGSIMPVFDALYDHRKELNHILVRHEQGATHAAQGFARVSGEVGVCLVTSGPGATNTI
                     TGIADAMIDSTPIVVIAGQVGTNFLGTDAFQEVDLVGITQPITKWSYQIRRAEDVAWAV
                     ARAFYVAKSGRPGPVVLDFAKNAQVEKTEYAPTKVDYVRSYLPVPEMEPEAIRKAAELI
                     NGAKRPLVLVGQGVELGEAQQELRAFIEKAGMPAGCTLLGLSALPTNHPLNKGMLGMHG
                     NLGPNINTNKCDVLIAVGMRFDDRVTGKLETYAKQAKIIHFDIDPAEIDKNVKTDVAVL
                     GDCKETLAAVTQLLEPANHQEWIDSFRQYEEVEEEKVIRPELHPAGKALSMGEVVRAVS
                     EATHNEAILVTDVGQNQMMSARYFKYSKERSIVTSGGLGTMGFGLPAAIGATFGRPDRT
                     VCVFMGDGGLQMNLQELGTIMEQKAPVKMILLNNNFLGNVRQWQAMFFNRRYSFTPMMN
                     PDYMKIASAYDIPARRVMTREELAKAIDEMIATDGPFLLEACVEEEGNVMPMTPPGGSV
                     NQMLLEC"
     CDS             complement(11360..11503)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ILVD_EDD"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg85_13"
                     /sec_met_domain="ILVD_EDD (E-value: 9.5e-08, bitscore:
                     20.7, seeds: 918, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="INVKLTDEELAARPMTPVTRNREVSKALKAYASMVSSADKGAVRL
                     ID"
ORIGIN
        1 acaacaaaca aatcgttttc cccggataat tgttttttca tgcaaaaaac agtgtttttt
       61 tactgagaag attaagcagt agagatacaa aaatctaatc gttccatcat ggagtaaatt
      121 tcattccacc atggagaaaa aatcgttcca ccatggtgga acgatttttc ccccgtgatg
      181 gaacgattta aaagatacaa gtctaatcct taccgtttct taatgggcac ataagtcacc
      241 tcatccaaaa cattcttata ggcaggacgg ataatacgct taccttcaaa gttcaattct
      301 tcattgcgat gtgcacacca accgacaata cgtgccatag caaacaaagg cgtgaagatt
      361 tcctgcggca gtccaatcat ctcgtagaca aagcccgaat agaaatccac attgctcgaa
      421 accgtctttc cattattctt cacacggcca aacacatcaa tggcgcgctc ctcgagcagt
      481 tcaaggaaag cgaactcacg ttctttccct ttttcgcggg caaggtcgcg ggcaagctcc
      541 ttcagcagaa tggcgcgcgg gtcggaaatg gtatagacgg catgtccgat accatatatc
      601 aaaccggtct tgttatagac ttccttgttg agcatgcggg tgaagtaagt atcaatctca
      661 tccacgttcg tccagtcctg aatgttttcc tgcagatggt ggaacatatc ggcaacctga
      721 atattggcac ctccgtgaag cggccctttc aaggaaccga tacctgccgc tatcgaagag
      781 taagtatccg tcccggtaga agaagtgaca cgtacggtaa aagtggagtt gttaccacca
      841 ccgtgctcgg cctgaagaac caacagcagg tcgagtgtgc gggcatccag ctccgtgtag
      901 tccttcttca gcatatagag gaaattctcg gcaatggaaa ggttttcctg cggatggcgg
      961 atatgcagtg aacggccatg ggtggcatgg cgaagcatgt tataggcata cgcaatgatg
     1021 gtcgggaatt tcgaaataag ctcaatgctc tgccgcatca gattatcgcg ggaagtgtca
     1081 tcggcatccg ggtcgaaacg gtacatctcg agcacgctgc gcgccaggat gttcataatg
     1141 ttgtttcctt caagttcaat gatattcatc ttggtcttct gctccagcgg catgttgtcg
     1201 ttgatgagtt cacggaaaga agagagttct tccttgtcgg gcaggcgacc ggaaagcaac
     1261 aagtaggcaa tttcctcaaa accgaaacgc ttctctttga tgatggcgtg tgccaagtca
     1321 tccacatcat aaccgcggta gaacaatttg ccgggaatag gcttcagccc tccaccgggg
     1381 atgcgttcat agccgaccac attgcctatt ttggtcaacc ccaccaagac tcccgtgccg
     1441 tcctcattac gcaaaccgcg cttcacatca aacttcctaa acagttcatt ctcaatccgg
     1501 gtagcttcct tcaaatcttc ggaaagcttg taaatcagat actccttctt cataatcgtt
     1561 tcgttttatt cgttattccc attttctatt ctccttacaa tctcccgggt gaaagtcgaa
     1621 gtggacagcg agacgctacc cggcataaaa cgggccaagt cggcagtagc acgggcttct
     1681 gtgaaacttt cctccaaggc gttctctata agagaggctg cttccttcca gcccagatat
     1741 tcaagcatca tcacagcgga aaggatgatg gaacagggat tcacaatgtc tttcccggca
     1801 atgttcggag ccgtcccgtg agtagcctca aaaatggcat gccccgtttt atagttgata
     1861 ttcgcacccg gtgcaatgcc gatgccgcct accatggcag ccagttggtc ggacacataa
     1921 tcaccgttca gattcaacgt ggcgatcacg gaatattctt cggggataag caacgtgttc
     1981 tgcaagaatg catcggcaat gcagtccttg atgaccagac gcccttctgc cagctcttta
     2041 ccaaactcac gttctgccag ttcgtacccc cacttcttaa aaccgccttc cgtaaatttc
     2101 atgatgtttc ctttgtgtac caaggtcacg gaaggcagat gatgctcaag cgcgtatcgg
     2161 caggcggcac gcaccaagcg ctctgttcct tctcttgaaa cgggcttcac gccaaacgag
     2221 gaggtttcgg gaaaacggac ttttgtcacc cccatgtcat cacggagaaa acgatagaac
     2281 ttttcagcct nnnnnnnnnn nnnnnnnnnn nnnnnnnttc gatgcctgca taaatatcct
     2341 cggtattctc acggaatacg cacatatcca ccttctgcgg ctctttgagt ggagaaacaa
     2401 tgcccttata ccaacgtacc ggacgttggc agacatacaa atcaagtgtc tgacgcaagg
     2461 ctacgttcaa ggaacggata cctccgccga cgggagttgt caaaggacct ttgatgccca
     2521 ccttataggt gcggaaggct tccatggttt cgtccggcaa ccaggagccg gtttcgtgga
     2581 aagcacgttc tcctgccagc acttctttcc attcaatgcc acgccggtcg ccataggatt
     2641 tcttgacagc ggcattcacg acagcctgca tggatggggt cacttctgct cccactccat
     2701 cgccggtaat aaaaggtaca gtaatttttt ccatattcta tcttgcatta agtgcagaac
     2761 cggcccggaa ccaagctatc tgctgttcgt tatacgtatg ttgtacttca aaactttctt
     2821 tactcccatc ctcgtgatga agaaccacct tcaacgtgcg tcccggagca aaatctttca
     2881 gccccatgac agaaatcagg tcgcgttccc gaatcttgtc ataatcggcc ttatccgtaa
     2941 aggtcagcgc caacatgcct tgtttcttta agttcgtctc atggatacgg gcaaaactct
     3001 tcgccaaaat gacgcgtaca ttcaggaagc gcggttccat ggcagcatgc tcacggctgg
     3061 aaccttcacc ataattctct tcggcaacga ccatggaagg gataccttcg gacttataca
     3121 gcttcgcagt gcctgacact gttccatagg tattggtgga gcggttccaa accttgttcg
     3181 tctctccatt gaaagcattg acagccccca tcagcatatt gtccgaaata ttctccaaat
     3241 gtccccggaa acggagccat ggccccgcca tggaaatgtg gtcggtggta catttcccct
     3301 gtactttaat caataaaggc atgtccagca aatccatgcc atcccaggca gggaagggag
     3361 tcagcagttg caagcgctgt gaatgaggat tgaccgtaat ttccgtctgt cctttgcctg
     3421 gagcaatgta tccttccttt cctcctataa acccgtgtgc cggcaattct tcaccgaccg
     3481 gttcggacag tttcacaacc tctcctttgg cattgaccag cgtatccctc aacgggtcga
     3541 aacaaaggtc accggcaatg gtcagcgcca tcgttatctc cggggaagcg acgtaagcaa
     3601 aagtgttggg atttccatcg gcacgtttgg caaaattacg gttaaaagag gtgacgatgg
     3661 aatttttgcg ttcggggtca tcagtatggc gcttccactg gccaatacaa ggtccgcagg
     3721 cattcgccat tatcgttgcg ccaatatctt cgaaagcggc aatcatgccg tcgcgttcag
     3781 cagtggcacg tatctgctcc gagccggggt tgacaatcag cgaggaagca accttcaaat
     3841 tcttttcctt tacctgccgg gcaagggagg ccgcgcggct caaatcctga taggacgaat
     3901 tggtgcacga ccctatcaga ccgacttcca tccggcgggg atagttattg gttatcacta
     3961 cctcggcaaa tttcgatatc ggtgttgctg catccggcgt aaagggcccg ttgatatacg
     4021 gttccaataa cgagaggtct atttcaatga tgcggtcgta atatttttcc ggatttgcca
     4081 gcacttcgtc gtcggcgcga aggtcggcag ctacggaagc agccatttcc gccacttctt
     4141 cacgtccggt agctttcaag taggtaccca tacgctcatc gtaagggaaa agggaggtag
     4201 tcgcccccac ctctgccccc atattgcaga tggtagcctt tccagtggca gacaatgaag
     4261 cggttcccgg tccaaaatat tcaatgatgg cattggttcc cccttttaca gtaagaatac
     4321 ccgccaactt cagaataacg tctttgggag ctacccagcc actcaattta cccttcaagt
     4381 gtacgcctat cagacgcggc tttttcagtt cccattccat gccggtcatc acatccaccg
     4441 catcggcacc acccacacca atggccacca tgcccaaacc tccggcattg ggcgtatgag
     4501 agtccgtgcc taccatcatt ccacccggaa atgcgnnnnn nnnnnaatac cacctggtga
     4561 ataatacctg ctcccggctg ccaaaaacct atgccatagc gggaagaaac atcacggaga
     4621 aaattataga cctcctcgtt ggtcttcgta gcagtcgcaa catcttcttt tgcaccttta
     4681 tatgcttgaa tcaaatggtc acaatgcaca gtggaaggca cggcaacctg ctcacggcct
     4741 gcattcataa attgcaataa ggccatttga gccgttgcat cctgcatggc cacacggtcg
     4801 ggacggaaat tcacatagtc ttctccccgt ctgtagttct tcactttatc cccatcatac
     4861 aaatgagcat acaaaatttt ctccgctaaa gtcatcggac gccgcagtac gttccgtacg
     4921 cgttctatct tctccgaata agcagcataa aacgttttga gcatcgttaa atcatatacc
     4981 ataaccacta ttttttagtt tttcattatt gtaaagatta caaattaata tcataaacaa
     5041 ataaaaaggc tgaatagttt aacaaaataa agcatttttt ccgtcggaag cgaagaatga
     5101 ttacctttgc aaccatgaag gaacaagatt caaatagtcc tattattcac ctccagcagc
     5161 aacaagtttt gctgcgcatg gaatacgaat acgaaaaaga ggaattcaaa cgccaaaccg
     5221 aaaacatggg agttgcccgg aaagtgaaac ggggactttg ctggtatcct gccactccgg
     5281 gacgaagtta ctataattca ctgaatcaat tagtaataga aattacacac acagaaaata
     5341 ccgatataga acataatttt gagttcggcc gtcccgtatg ttttttccgc cagtctgctg
     5401 atggaaaaat aacctatatg aacttcaccg ctaccgtaag ctatgccgac gagacacgga
     5461 tggtagcgat aatgcccgga gccggtgccg ttatggaagt gcaggaaacg gacaacctcg
     5521 gcgtgcaact ttatttcgac gaaacatcct atcggaccat gttcgaagcc ttggaagata
     5581 cgttacgctc caaaggcaac cgcctggccg aattgcggga catattgctg ggaacctcga
     5641 aagccggttt ccgagagctc tatcccgtac ggtttccctg gctgaactcc acgcaggaga
     5701 cagctgtaaa caaagtgctg tgtgcccgcg acgtggccat tgtacacggt cctccgggaa
     5761 ccggaaaaac gaccacctta gtggaagcca tctacgaaac cctgcatcgg gaaccgcagg
     5821 tactggtatg tgcccaaagc aatactgccg tcgactggat ttcggaaaaa cttgtggacc
     5881 gtggcgtcaa tgtcctgcgt atcggcaatc cgacccgtgt caacgacaag atgctttcct
     5941 ttacctacga gcgtcgtttc gagaaccatc cgctttatcc ggagctgtgg agcatccgga
     6001 aaaatctccg tgaactgggc agccgtgccc gccgtggcag ctatgacgaa cgcgaaggag
     6061 tacgcagccg tatgagccgc ctgcgcgann nnnnnnnnnn nncgcattgg aaatacaaat
     6121 caatgcagag ctttttgatg gggcacatgt catagcctcc acgctagtaa gcagcaatca
     6181 ccggctgctg aacggacgcc gtttcggcac ccttttcatt gatgaagcag cccaggcctt
     6241 agaagctgcc tgctggatag ctatccgaaa agcagaccgc gtggtgttgg cgggtgacca
     6301 ctgccaactt cnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     6361 nnnnnnnnnn nnnnnnnnnc aaccctgccg ttgtctcttt gctgaaagta caataccgca
     6421 tgcacgagga aatcatgaaa tttccttccc aatggtttta taatggcgag ttggaagccg
     6481 ctcccgaagt gcgttaccgg ggcatcctgg actgggatac ccccatccac tggattgaca
     6541 cctccgaaat ggatttcaaa gaagaatttg tgggagagac tttcggacgc attaataagg
     6601 cggaagcgga cctgctccta tcagaactga aaatctacat caaccgtatc ggtggcaacc
     6661 gcattctgga agaaaaaata gacatcggca tcatctcccc ttacaaggca caagtgcaat
     6721 atctccgcag caagataaag gcagacgctt cactcaagcc ttatcgcagc ttgttcactg
     6781 taaatacggt ggatggcttc caagggcaag agcgcgatgt tatcttcatc agccttgtcc
     6841 gtgccaacga agaaggacag ataggattcc tgaatgattt aaggagaatg aatgtagcca
     6901 tcacccgggc acgtatgaag ctggtgatat tgggagaggc agagacgctg aaacatcacg
     6961 gtttttaccg gaagctattg gagtttattc aaaatatagg gaatcaataa taaagaaata
     7021 ccccctccgg taacaccgaa gagggtattt cacctattta tataaagctg attaattgtt
     7081 ttccggacga agtttacgaa ctgtaacagc tgtctgccac atttcgcttt cacgcaaggc
     7141 tttcaattct gcattcagct tctcacgata atcgggtttg gagttactgt cgatagaaat
     7201 ctgagcttcg ttgcccgact tcacacttgc atacaatttc tgtacaaccg gcttgatggc
     7261 atcatggaac ggggtcatcc aatccagcgc accacgctgt gccgtagtag aacagttggc
     7321 atacatccag tccataccgt tcttggcaaa caatggcatc aaagattgag tcaactcttc
     7381 cactgtttca ttgaatgctt cagaaggagt atggccgttt tcgcgcaata cttcatactg
     7441 agccaacagc aatccctgga tagcacccat caatgaaccg cgttcaccgg tcaagtcgga
     7501 agtggcttcg cggatgaaag ttgtctcgaa caaatatccc gaaccgatgc cgatacccag
     7561 tgcaatcgtc ttgtcaaaag ccttacccgt agcatcctga tagacggcat atgatgagtt
     7621 caagccacga ccctcgagga acatggtacg aagtgaagta ccggaacctt tgggagcaac
     7681 cataataaca tcaatatctt taggaggaac cacgccggta cggtcgttcc aggtaatagc
     7741 aaaaccatga gagaagtaaa gnnnnnnnnn nttttcctgc agtcagataa ggcttgatag
     7801 taggccatac agacattact gctgcgtcag acaacagaca catgatgata gtacctttct
     7861 gacaagcctc ttcgatgccg aacaaagtct cacccggtac ccatccgtca gccacagcct
     7921 tttcgtatgt cttacccgga cgttgtccta caatcacatt gaaaccgtta tcacgcaagt
     7981 tgcaagcctg gcccgggcct tgtacgccat aannnnnnnn nnnnnnnnnn nnnnnnnnnn
     8041 nnnnnnnnnn nnnnnnttcc aaaggaaatt cttcgcgggt cattacattc tcaataacac
     8101 cgccaaaatt caattgtgcc attttttgtt ttaattttta tttgtggctt acgccaacgt
     8161 tgataaattt atttatttct ctgtaaatat cactttagag cgacagacca cttcgctgcc
     8221 attctttttc acctccacat cgtaaacgcc ctcaccggca tcatccatga acaaagtcaa
     8281 ctcatcccca taatagcttt cggctacata tgccatttca aaacgacgga tgcgcttctc
     8341 cttatacatc tctatcggga acaaatcaag gatatgctcg atgtaacgga tgctgttcac
     8401 atgcccgtta atgtcaatat cactgtattt ggctaccaaa gcagcaaccg gttcctttga
     8461 ggccaccttt atccgcgaag gtttttctat cgggcaaggc tcatcgcaaa cataatctac
     8521 aatgctgcca ctatgaagag ccagcaaatc tgccggctta cgggtattca tgctaatcat
     8581 cgcccaaacg gaacgtgcat acccaatctt cttaccctcc ttatcgatga tagcgaaatt
     8641 acggtctgta aaaaggcgat agacattctc cacccaagtc tgaatggaga aatcttcgta
     8701 ctgataaggc atttcatcca gttcgacagc cagacgggac aatacccaag tataattgtc
     8761 ctcgtttaga gtcgcgatgc caaaaccgcg gtcgctggca tggaaacccg cacaattcaa
     8821 caaatggttg cccaatactc ccattgtcag ccgtccggta aagtcgacat gaaacggttc
     8881 ggcaacaaac ttgtaggtac ctattttatt gttctcgctc atcatgattc ctggtgttta
     8941 ctttgacgat attttgcttc acggtccgcc agatattcat tgacacgctc aaagcagctg
     9001 gtcgtaatgg ctacgcgacc cgaacggacg aactgaagta cgcaatccaa ctggcgcaac
     9061 tcctcataaa gattggttat ttcctcactc atgccattct tctcaacaat ggcaaataca
     9121 gcattcacct ccacaatacg ggcattgtac ttacggatta ctttggacac ctccggtttt
     9181 tcttccagcg taggggtcgt tattttataa agggcaatct cgtgctgata gatttcatca
     9241 tccgtgaaat aatgggcttg cagcacatct attttcttgg taatctgctt gnnnnnnnnn
     9301 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     9361 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnntgccg gcgggtaaac acagccgtca
     9421 cctgattcag caaaccggca aagttttccg aatgaacaat gattgtatat agttttttat
     9481 ccatagatag agtaaattct ttaatttcgc atgacttcag cattccaaca acatctgatt
     9541 gaccgaaccg cccggaggtg tcatcggcat tacatttcct tcttcctcca cacaagcttc
     9601 gagcaggaac ggtccgtcag tcgctatcat ctcgtcaatc gcttttgcca gctcctcgcg
     9661 ggtcattacc ctgcgtgcag gaatatcata tgccgaagca atcttcatat aatccggatt
     9721 catcatcgga gtaaacgaat aacgacgatt gaagaacatc gcctgccatt gacgaacatt
     9781 gcccaagaag ttattgttca acagaatcat cttcaccgga gccttttgtt ccatgatggt
     9841 acccagttcc tgcaggttca tctgcaagcc gccgtctccc atgaatacgc ataccgtgcg
     9901 gtccggacgt ccaaaagtgg caccgatagc tgccggaagg ccgaagccca tagtacccag
     9961 gccaccggaa gtaacaatgc tacgttcctt gctgtatttg aaataacggg cggacatcat
    10021 ctgattctgg ccgacatcag tcaccaatat cgcctcgtta tgggtagcct cactcacagc
    10081 acgcaccacc tcacccatgc ttagcgcttt tcctgccgga tgtaattccg gacggattac
    10141 cttttcctct tccacttcct cgtattgccg gaaactgtca atccattcct gatggttggc
    10201 gggttccagc aattgggtaa cggcagccag tgtctctttg caatctccca ggacagcaac
    10261 atcagtcttt acattcttat ctatttcggc agggtcaata tcaaagtgga taatcttcgc
    10321 ctgcttggca tatgtttcca atttacccgt cacacggtca tcaaagcgca tgcctacggc
    10381 gataaggaca tcacatttat tggtattgat attgggcccc aggttaccgt gcataccaag
    10441 cattcctttg ttcaacggat ggttcgtagg taatgcggaa agtcccaata aagtgcatcc
    10501 ggcaggcatt ccggctttct caatgaaagc acgaagctct tgctgggctt ctcccagctc
    10561 cacgccttgt ccaaccagca ccaaaggccg tttcgcacca tttattaatt cagcagcctt
    10621 ccgtatggcc tccggctcca tttcgggaac gggaagatag ctacggacat agtccacctt
    10681 agtaggcgca tattctgttt tctccacttg ggcgttttta gcaaaatcca gcacgaccgg
    10741 tcccggacgt ccgctctttg ccacatagaa agcacgtgcc actgcccagg ccacatcttc
    10801 tgcacgacga atctggtaac tccatttcgt gataggctga gtaatgccta ccaagtccac
    10861 ttcctgaaat gcatccgtac ccaagaagtt cgtccctacc tggccggcaa tgacaacgat
    10921 aggcgtactg tcaatcatgg catctgcaat gcccgtgata gtattggtag cacccggtcc
    10981 actggtaacc agacaaacgc caacctcgcc tgatacacgt gcaaagcctt gtgccgcatg
    11041 ggttgctcct tgttcatgac gaaccaagat gtggttcaat tccttccgat ggtcgtataa
    11101 ggcatcgaat accggcatga tgctccctcc cggataaccg aaaatagtct ttactccctg
    11161 atgctccaga gagcgcatca atgcttctgc gcctgttatt agagcctcac cccgaccctc
    11221 tccttgggag agggaggaaa agttactctt tttattatta tcagccatac tttatctatt
    11281 cattatattt aaaagctcaa tagtagcttg aaaaatttgt ttcattctct cctcccctcg
    11341 ctttcggaaa ggggggcttt taatcaatca gcctcacagc ccctttgtca gcggaactca
    11401 ccatactggc atatgctttc aatgctttgg agacttcacg gttgcgggtt accggagtca
    11461 tagggcgtgc tgcaagctct tcatccgtca acttcacatt gata
//
