LOCUS       gnlProkkaCLIHIBEO_25   13173 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|CLIHIBEO_25.
ACCESSION   gnlProkkaCLIHIBEO_25
VERSION     gnlProkkaCLIHIBEO_25
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-12-01 21:38:14
            Original ID  :: gnl|Prokka|CLIHIBEO_25
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13173
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13173
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[3859:8173]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      3860..8173
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..13173
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..13173
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             3..206
                     /locus_tag="ctg25_1"
                     /transl_table=11
                     /translation="MPEQDATLCLAILQGYNVSMYANPEDEDRKRSVLQRSLTLLDVLP
                     PSLLKQQLSAVCHGMQELCETN"
     CDS             222..2633
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Poly_export"
                     /gene_functions="transport (smcogs)
                     SMCOG1186:polysaccharide export protein (Score: 30.3;
                     E-value: 2.7e-09)"
                     /gene_kind="transport"
                     /locus_tag="ctg25_2"
                     /sec_met_domain="Poly_export (E-value: 1.5e-17, bitscore:
                     55.7, seeds: 183, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIQRLFSILLFCSMLGSGSLMAQSMSDSQVLEYVKDGIRQGKEQ
                     KQLASELARKGVTKEQAMRVKQLYEQQNNVNTSQSTGTDINESRLREETKENTSDMLED
                     HPTTEDLAREDQVFGRNIFNTRNLTFEPSVNLATPANYRLGPGDEVIIDIWGASQNTIR
                     QQISPEGTINIQKIGPVNLSGMTVSAANDYLKGALNKIYNGLNNTTDPTSDIRLTLGNI
                     RTIQINVMGEVVQPGTYALSSFSTVFHALYRAGGVSDIGSLRNVQLVRNGKNIATIDVY
                     EFIMKGNTQDDIRLQEGDVVIVPAYDVLVKISGKVKRPMRFEMKKDENLATLIKYAGGF
                     EADAYTRSLRVVRQNGEEYEVNTVKDMDYSIYTMRNGDVVTAEAILNRFTNKLEIRGAV
                     YRPGIYQLSGKLNTIRELVNEAQGLTGDAFLNRAVLYRQREDLTSEVVQIDIKSIMNGT
                     SPNLALMKNDILYIPSIHDLEDRGNVTVHGEVAHPDSYPYADNMTLEDLIIQAGGLKEA
                     ASTVRIDVSRRIKNPRSTADNDTIGQMYTFSLKDGFVIDGQPGFILQPYDEVYVRRSPG
                     YQAQQNVVIDGEILFGGNYAMTNREERLSDLVNKAGGPTSLAYLRGAKLTRVASAGEKK
                     RMGDVIRLMSRQLGEAMIDSLGIGVEDTFTVGIDLEKALTNPKGSADLVLREGDVVFIP
                     KNTNTVTINGAVMVPNTVSYMKGKDVDYYLNQAGGYSDNARKSKKFIVYMNGQVTKVKG
                     SGKKQIEPGCEIIVPGKAKKKGNIANILGYATSFSSLGMMIASIANLIKK"
     CDS             2648..3796
                     /locus_tag="ctg25_3"
                     /transl_table=11
                     /translation="MSEQRQDKNLLSEPHKTESDEIEIDLVDIFRKIIAIRKKLYKAVG
                     IGFIIGIIVAVSIPKQYTVKVTLSPEMGNAKGSNGLAGLAASFLGDGALIGESTDALNA
                     SLSADIVSSTPFLLELLEMEVSVSKKDDKMTLGSYLDEESSPWWDYLIGFPGIVIGGVK
                     SLFGEDTVPASGGRQGTIELTKEVNEKINFLKKKISASIDKKTAITSITVTLQNPQITA
                     VIADSVVHKLQEYIIGYRTSKVKEDCAYLERLFKERQQEYYAAQRKYADYVDAHDNVVL
                     QSVRAEQERLQNDMSLAYQIYSQVANQLQVSRAKVQEEKPVFAVVEPAVVPLKPSGMGL
                     KIYILLFVFLSVSGTLVWVFFGKSLLASLRKELKNKEIEQDK"
     CDS             3860..4579
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064:glucose-1-phosphate
                     adenylyl/thymidylyltransferase (Score: 56.8; E-value:
                     3.1e-17)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg25_4"
                     /sec_met_domain="NTP_transf_3 (E-value: 2.1e-16, bitscore:
                     52.9, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRTAMIMAAGMGTRFGQYTELIPKGFVKVGGIPMIVRSIDTLLS
                     CGIERIVIGTGYKQEVYEELKTDYPMLETCFSPRYAETNSMYTLYNTREILGNDDFLLL
                     ESDLIFEKQAIMSLLECPAADAMLIAPVTKFQDQYYVEHDDNFRLSSCSVNKNKLNAKG
                     ELVGIHKLSGSFYKIMCADYASIVDEQPNLGYEYELLRISCSQSPVYVHKVEGLKWYEI
                     DDISDLEYAEKYIVPYC"
     CDS             4600..5901
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 208.9;
                     E-value: 1.5e-63)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg25_5"
                     /sec_met_domain="CTP_transf_like (E-value: 1.1e-12,
                     bitscore: 40.6, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates (E-value: 1.2e-120, bitscore:
                     394.2, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 1.3e-62, bitscore:
                     203.6, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKTVYIGMTADIMHPGLIRIINEATKYGDVIIGLLTDKAIAEHK
                     RLPYLTYEQRKEVVQNIKGVCKVVPQEEWSYVENLKRIKPDYIIHGDDWKTGPLREERV
                     RVFEVMNEQGGKVIEIPYTLGINSSSLDKDIKAIGTTPDVRLKSLRRLINAKPVVRILE
                     AHDGLCGLIIENQEILKGDKREVFDGMWSSSLTDSTSKGKPDIEAVDLTTRLQDLNNIL
                     ECTTKPIIFDGDTGGKIEHFVFTVRTLERHGISAIIIEDKVGLKKNSLFGTDVIQTQDT
                     IEGFCNKIKAGKASQITDDFMIIARIESLIAGKPVSDALERAFAYVQAGADGIMIHSKN
                     KSGEDIKEFCLAFRKQYAHVPIVVVPTTYDHIYESELCDWGVNIIIYANHMLRAAYPAM
                     MNVAKIILENERALEVRELCMPIKEILELIPGTK"
     CDS             5918..7042
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 58.1;
                     E-value: 1.1e-17)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg25_6"
                     /sec_met_domain="TPP_enzyme_N (E-value: 6.1e-20, bitscore:
                     63.7, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 5.3e-20, bitscore:
                     64.0, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLSVEKVYETFLSHDVDFFTGVPDSLLKNICAYITDHTSREKHII
                     AANEGAAVGIASGYYMASGKVPVVYMQNSGLGNTVNPLLSLADEQVYSFPMLLMIGWRG
                     EPGTKDEPQHKKQGEVTLDLLKAMRIPYIILDSNENDAFIQLHDIIQSAKTKNIPHAII
                     IRKDVFGKYKLQKEFGCNYPLSREDALQIVVDYLPENSVVVSTTGKLSRELFEYREMKE
                     QGHEHDFLTVGSMGHSSSISLGIAIAKQDRPVYCLDGDGAFIMHLGAISNIGDLSPKNY
                     YHILFNNGAHESVGGQPTLGFSLDIPAIVRGSGYKHTYTVCTKVEIEEAMKQLPKLCGP
                     VLLEIKVKIDSRENLGRPTTTPIENKEHFMDFLK"
     CDS             7052..8173
                     /NRPS_PKS="Domain: Aminotran_5 (30-366). E-value: 2.9e-34.
                     Score: 110.4. Matches aSDomain:
                     nrpspksdomains_ctg25_7_Aminotran_5.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139:aminotransferase class V (Score: 76.3; E-value:
                     3.6e-23)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg25_7"
                     /sec_met_domain="Aminotran_5 (E-value: 8.7e-31, bitscore:
                     99.3, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIERKILLNPGPATTTDSVKMAQVVPDICPREKEFAGMMKQLRD
                     DLVRVAHGNLEKHTAVLFCGSGTINIDICLNSLLPEDKRVLIVNNGAYSTRAVEVCQYY
                     GLPHINLEFSVYERPDLSVVENVLQENPDIAMVYTTHHETGTGILNPIREMGAIAHKYQ
                     AKFVVDTTSSLGMIPFDIEKDNVDFCMASAQKGLQAMTGLSFIIGNEEQIKFSKKYPKR
                     SYYCNLYLQYENFERTGEMHFTPPVQTIYATRQALNEYFEVGEEAKFARHKRVFEAIHS
                     GINEIGLKSVIKREWQSGLVVSVQYPEDPNWDFEKIHDYCYERGFTIYPGKISTEDTFR
                     ICALGEIEVDDIENFFKVLKAALNHYNVTLPMS"
     aSDomain        7142..8149
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg25_7_Aminotran_5.1"
                     /evalue="2.90E-34"
                     /label="ctg25_7_Aminotran_5.1"
                     /locus_tag="ctg25_7"
                     /protein_end="366"
                     /protein_start="30"
                     /score="110.4"
                     /tool="antismash"
                     /translation="PREKEFAGMMKQLRDDLVRVAHGNLEKHTAVLFCGSGTINIDICL
                     NSLLPEDKRVLIVNNGAYSTRAVEVCQYYGLPHINLEFSVYERPDLSVVENVLQENPDI
                     AMVYTTHHETGTGILNPIREMGAIAHKYQAKFVVDTTSSLGMIPFDIEKDNVDFCMASA
                     QKGLQAMTGLSFIIGNEEQIKFSKKYPKRSYYCNLYLQYENFERTGEMHFTPPVQTIYA
                     TRQALNEYFEVGEEAKFARHKRVFEAIHSGINEIGLKSVIKREWQSGLVVSVQYPEDPN
                     WDFEKIHDYCYERGFTIYPGKISTEDTFRICALGEIEVDDIENFFKVLKAALNHY"
     CDS             8170..8313
                     /locus_tag="ctg25_8"
                     /transl_table=11
                     /translation="MIAEILLKIRHFYFSLRGIHFHPESVISGVPIRSFRLVGKYGNIN
                     LR"
     CDS             8516..10000
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg25_9"
                     /sec_met_domain="Polysacc_synt (E-value: 7.7e-31, bitscore:
                     99.7, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MENLKQKTVSGIMWSAIERFSLQGVQFIIQIILARLLLPSDYGMI
                     GMLAIFLQVAQVFIDSGFTNALIQKKDRTEEDFATVFYFNILVAVLFYGILFFSASLIA
                     DFYNMPTLVLVIRFIALSLIINALSAIHRTKLIISVNFKTQSKISLGAAFISGVIGIWM
                     AYVGCGVWALVWQTLLNSIILTILFYCLVHWKPLHTFSKSSFERLFNFGSKLLISSLIN
                     TVYRNLYTIVIGKKFSVVELGYYTRAEQFAIFPSNNLNALVSRVAYPILSSIQDDDKCL
                     TNAYRNYIRLSSYIIFPLMVGLLVLANPIISLLLTDKWSGVVILLQILCLDWMFDHLSQ
                     INLNLLWVKGRSDLSLRLEIIKKTIAIFILFVSIPFGLEVMCWGRVIYSLIATYLNTYY
                     TNSLIDLTLKLQVKDVFPSLILSFIMGGIVFICISFFETDIVKIVIGCITGMSFYILLS
                     FLFKLDSFFCILTLIIKTKNIDENIKKDFSSNSKDN"
     CDS             9954..11213
                     /locus_tag="ctg25_10"
                     /transl_table=11
                     /translation="MKILKKIFQVIVKIINHCVPVDSRSLYFIPHPNCRTDKYDIINYS
                     SDNVLVLLNYLLKKDSAEYYKIYVEIYDSSRISEYQEYIYGINPNIRCTFLCACVGRFF
                     FNKVSFKDMLYAFFCFCRASKCFTATFYYDFSFKKRSQQIICLGYYTPFKDDYHMGDHS
                     YDKFRNTTCNSFDYSIATSCLSARIISIDCGISYDKFKVLGFPRNDLLISKNNCNVIKR
                     EISKFAGYDVTKYIVYTPTFRDYETVTEGNLRSILGYVDCDLLKLSKILLKFNAALILK
                     LHPLQNKTVLKKDLPKGILVFEQTYKYGLYDLLSFSDGMITDYTSTYFDFLLVNKPVIF
                     NFYDIEEYRRVRGFSFEPIEFFCAGDIVYNYNELIDAVMGLLAGKDIHAEHRRHISLLM
                     NQFQDDNSTKRICDIFLNEI"
     CDS             11222..11968
                     /locus_tag="ctg25_11"
                     /transl_table=11
                     /translation="MNYAFVVQARLGSTRLPGKILKPFYGNQSILDLMVHKLSAISNIP
                     VIIATTNSVINEPIEKKALALGVKCFRGEENDVLKRFIDVAEYFDIQGIFRICSDNPFL
                     DVHAARQLVEIAMKSCNDYISFDIDGTPSIKTHFGFWGEFVTLDALKRVIGFTDDLLYR
                     EHVTNYIYSHPELFNIQWISGSPVVSKHHNIRLTIDTLEDFSVAQRIYRDLQEKRVEIS
                     IEVIVDYVRRHAEYIQLMKQQIKKKF"
     CDS             11972..13012
                     /locus_tag="ctg25_12"
                     /transl_table=11
                     /translation="MKNTYIIGEIGQNHNGSVDLAKLIIELISRPVHEDVFGMDFMPMN
                     AVKMTKRDLSEELAVSQMNQIYDNPNSFGRTYGEHRAFLELDDQAHFEIYKYAKSLGLD
                     FIETLCAKGCLSLLKLFTPDRLKVASRDLTNLPLLEALAETHIPIILSTGMAGQRELDN
                     ALDVITRYHSNIAILHCVSQYPTHPNNLNLRTITYLKKHYNKFEIGFSDHTIGISAATA
                     AVAMGAEIIEKHVTIDRHMKGTDQLGSLGPDGVNRMIRDIRIAECWLGTEDLYIEKGVE
                     KSKIKLERSIATRKYIPAGSIIQESDIHLLSPGDGYKWIDKKNVIGHFAKQDISANEII
                     YPDFIE"
ORIGIN
        1 agacaccgga gcaggatgct accctgtgtt tggccatcct tcagggatat aatgtgtcga
       61 tgtacgccaa tccggaagac gaggatagaa aacggtctgt cttgcagcgt tctctgaccc
      121 tccttgatgt tcttccccct tctcttctta aacaacagtt gtctgcggtc tgtcacggta
      181 tgcaggaact gtgtgaaacc aactaacttt tttatttgtc aatgaaaata caacgacttt
      241 ttagcattct acttttttgt tctatgctgg gaagtggctc gcttatggcc cagtccatga
      301 gtgactcaca ggtactggaa tatgtaaagg acggcatccg gcaaggcaag gaacagaaac
      361 agcttgcttc cgagcttgcg cgtaaaggtg tgaccaagga acaggctatg cgtgtgaagc
      421 agctctatga gcagcagaac aatgtaaaca cctcccaatc cacgggtacg gatatcaacg
      481 agtcccgcct tcgtgaagag actaaggaga atacttccga catgctggag gatcatccga
      541 ctacggaaga tttggcccgt gaggaccagg ttttcgggcg caacatcttc aatacccgca
      601 acctgacgtt cgagcctagt gtcaaccttg ccactcctgc caattaccgt ctgggtcccg
      661 gtgatgaagt catcatcgat atctggggtg ccagccagaa cacgatccgc cagcagatct
      721 ctcctgaagg caccatcaat attcagaaga tcgggcctgt caaccttagc ggtatgacag
      781 tctccgccgc caacgactat ctgaagggcg ccctgaataa gatctataac ggtctgaaca
      841 atactaccga ccctacttcc gacatccgtc tgactttggg taatatccgt actatccaga
      901 tcaatgtgat gggagaagtc gtgcagccgg gtacctacgc cctttcctcc ttctctaccg
      961 tcttccacgc gctttaccgt gcaggcggcg tgagtgatat cggcagcctc cgaaacgttc
     1021 agttggtacg caacggaaag aatatcgcca ccatcgatgt ttacgaattt atcatgaaag
     1081 gcaacacaca ggatgacatc cgccttcagg aaggtgacgt ggttatcgtc cccgcctacg
     1141 atgtcttggt aaagatcagc ggcaaggtaa aacgtcctat gcgtttcgaa atgaagaaag
     1201 acgagaacct tgccacttta atcaaatatg ccggcggctt tgaagctgac gcctacaccc
     1261 gttcattacg tgttgtccgt cagaatggtg aggaatatga ggtcaacaca gtcaaggata
     1321 tggactacag catctacaca atgcgtaacg gcgacgttgt aacagccgaa gccatcctta
     1381 accgcttcac aaacaaactg gaaatccgtg gcgctgtcta tcgtcccggc atctaccagc
     1441 tcagcggtaa actgaacacg atccgcgaac ttgtcaatga agcccagggt ctgaccggtg
     1501 acgctttcct gaatcgtgcc gtcctttatc gccagcgtga ggacctgacc agtgaagttg
     1561 ttcagataga tatcaagtct atcatgaacg gtacttcccc gaaccttgcc ctgatgaaga
     1621 atgacattct ctacatcccg agcattcacg atctggaaga tcgtggcaat gtcacagttc
     1681 acggtgaagt cgcgcacccc gattcctatc cctatgctga taacatgaca cttgaggatc
     1741 tgatcatcca ggccggtggc ttgaaagaag ccgcctctac tgtccgcatt gatgtgtcga
     1801 gacgaatcaa gaatccccgt agtaccgcgg ataatgatac tatcggtcag atgtatacct
     1861 tctctttaaa ggatggtttt gtcatcgacg gtcagcccgg ttttatcctt cagccttatg
     1921 acgaagttta tgtccgtcgc agtcccggtt atcaggcgca acagaatgta gtcattgatg
     1981 gtgaaatatt gtttggagga aattatgcca tgaccaaccg tgaggaacgt ctttccgatc
     2041 tggtgaataa agcgggtggt cctaccagtc ttgcctatct ccgtggtgcg aaattgaccc
     2101 gtgtggcaag tgccggtgag aagaaacgta tgggtgatgt gattcgcctg atgagcaggc
     2161 aattgggtga agccatgatt gactctttgg gtattggtgt tgaggatacc tttacggtag
     2221 gcattgatct ggagaaggct ttgactaatc ctaagggtag tgccgacctt gtcctacgtg
     2281 aaggtgatgt ggtctttata cctaagaata ctaatactgt aactatcaat ggtgctgtta
     2341 tggtccccaa tacggtttct tatatgaagg gaaaggatgt ggattattac ctgaatcagg
     2401 ccggtggcta ttctgataat gcaaggaaga gtaagaagtt cattgtttac atgaatggtc
     2461 aggtgacgaa ggttaagggt agtggtaaga aacagattga gccggggtgt gagattattg
     2521 tgcctggtaa ggctaagaag aaagggaaca tagctaatat tttaggttat gctacttcct
     2581 tcagttcttt gggaatgatg attgcttcta ttgctaatct tataaagaaa taatagaatt
     2641 tacttttatg tcagaacaac gacaggataa aaacttgctc tctgaaccac acaagacaga
     2701 aagtgatgag atagaaattg atttggtcga tatctttcgc aagattattg ctattcgtaa
     2761 aaaattatac aaagccgttg gaattggttt tattattgga ataattgtag cggtaagtat
     2821 ccctaaacag tatacagtaa aggttaccct ttctcctgaa atgggtaatg cgaaggggag
     2881 taatggttta gccggacttg ctgcctcgtt tttaggagat ggggctctaa taggggaaag
     2941 cacagatgcc ttgaacgctt ctctttcagc agatattgtt tcttcaactc cttttttatt
     3001 ggaactttta gaaatggaag tctccgtttc taaaaaggat gataaaatga ctttggggtc
     3061 ttatctcgat gaagagtcat ctccttggtg ggattatctt ataggttttc cgggcatagt
     3121 aataggagga gttaaatcat tattcggaga agatacggtt cctgccagtg gagggcggca
     3181 aggaactatc gaattgacga aagaagtaaa tgagaagatt aattttctta aaaagaagat
     3241 tagtgcatcc attgataaga aaaccgccat aacgagcatt acggtcacct tacaaaatcc
     3301 gcagatcact gcggttatag cagattctgt cgttcataaa ttacaggaat atattattgg
     3361 gtatcgaact tcaaaagtaa aagaagactg tgcgtatttg gaacggttgt ttaaagaacg
     3421 tcagcaggaa tattatgctg ctcaaagaaa atatgcggat tatgtagacg cccatgataa
     3481 tgtggttctt caaagtgtac gtgctgagca ggagcgttta cagaacgaca tgagtttggc
     3541 ttatcagata tatagtcagg ttgctaatca gttgcaggta tccagagcca aagtacagga
     3601 ggaaaagcca gtctttgcag tagttgagcc tgccgttgta cctttgaaac cttcaggtat
     3661 gggactcaaa atttatattt tattatttgt gttcctgtcc gtatctggta ctctcgtgtg
     3721 ggtgtttttt ggcaaaagtc tgctggctag cttgagaaaa gaactgaaaa ataaggagat
     3781 agaacaggat aaatgatgct aaaacgtcgt ttacaacatt cttacatcaa ttaaattcac
     3841 ttactatatt attaaacgaa tgatacgtac agctatgata atggctgcgg gcatgggaac
     3901 ccgttttggc caatatacag aattgatacc taaagggttc gtcaaagtgg gaggtattcc
     3961 aatgatagtt cgttctattg atactttgtt atcatgtggc attgagcgaa ttgtaatcgg
     4021 tacaggatat aaacaagaag tttatgaaga attgaagaca gactatccta tgcttgaaac
     4081 ctgttttagt cctcgttatg ctgaaacaaa tagtatgtat actttatata atacgcggga
     4141 gattctgggc aatgatgatt ttttattgtt agagtcagat ttgatttttg agaaacaagc
     4201 aataatgagc ttattggagt gtcctgcggc agatgcaatg ctaatagctc cagtgacaaa
     4261 gtttcaagat cagtattatg tggaacatga tgataatttt cgcctttctt catgttctgt
     4321 caataagaat aaactaaacg ctaaaggcga attggtcggc atccataaac tatccggttc
     4381 cttttacaaa ataatgtgtg ctgattatgc gagtattgtt gatgaacaac ccaatttggg
     4441 atatgagtat gaattactac gaatatcttg ttctcaatct cctgtttatg tgcataaagt
     4501 agaagggctg aaatggtatg aaatcgatga catatcagat ttggaatatg cagagaaata
     4561 tattgttccg tattgttaat taaaataata tatcaaatta tgagtaagac agtttatatt
     4621 gggatgactg cggatattat gcatccagga cttatccgca ttattaatga ggctactaaa
     4681 tacggtgatg ttataattgg tcttcttaca gataaagcta ttgcggagca taaacgcctt
     4741 ccttatctga cctatgaaca acgaaaagag gtagttcaga atattaaagg cgtatgtaaa
     4801 gttgttcctc aagaagaatg gagctatgtt gagaatctca aacgcattaa acctgactat
     4861 ataattcatg gtgacgactg gaaaaccggg cctttacgtg aagaacgtgt gcgcgtattt
     4921 gaagtgatga atgaacaggg aggaaaggtt atcgaaattc catatacttt gggaattaat
     4981 tcatcttctt tggataaaga tattaaggct ataggtacaa cccctgatgt acgtttaaaa
     5041 tcacttcgtc gtttgataaa tgccaaaccc gtagttcgta ttttggaagc tcatgatgga
     5101 ctatgtggct tgataattga aaatcaggaa atattaaaag gggataagag ggaagtattt
     5161 gacggaatgt ggtctagtag ccttacggat tcaaccagta aaggtaaacc tgatattgag
     5221 gcggttgatt taactacccg attgcaagat ttgaataata ttctggagtg tactactaaa
     5281 cctattattt ttgatggaga tacaggtggt aaaattgaac atttcgtatt tacagtacgc
     5341 actttagaac gtcatggaat ttcagctata ataattgaag ataaagttgg attaaaaaag
     5401 aattcattgt ttggtacaga tgttattcaa actcaagata caatcgaagg tttctgtaat
     5461 aagatcaaag caggaaaggc atctcagatt actgatgatt ttatgattat cgctcgtatt
     5521 gagagcctta tagcgggaaa gccggtaagt gatgctttag agagagcttt tgcatatgtc
     5581 caagcgggag cggacggtat tatgatacat agcaaaaata agtcgggtga agatataaaa
     5641 gaattttgtt tggcgtttcg aaaacagtat gctcatgtac ctatcgtggt tgtgcctact
     5701 acatatgatc atatttatga gtctgaattg tgtgattggg gtgtgaatat aattatttat
     5761 gctaatcata tgcttcgtgc cgcttatcct gctatgatga atgtcgcaaa gataatatta
     5821 gagaatgaac gtgctttaga ggtgcgcgaa ctgtgtatgc ccataaaaga aatattggaa
     5881 ctgattccag gtactaaata aaaagaggaa tatcattatg ttaagcgtag aaaaagttta
     5941 tgaaacgttt ctgagtcatg acgttgattt ttttacagga gttccagact cattactaaa
     6001 aaatatttgt gcctatatca cagaccatac ttcacgtgag aaacatatca tagctgctaa
     6061 tgaaggtgcg gctgtaggaa ttgcttcagg ttattatatg gcatcaggta aggttcctgt
     6121 ggtttatatg caaaattccg gcttgggtaa tactgttaat cctctgctgt ctcttgcaga
     6181 tgaacaagta tacagttttc caatgctttt gatgattggc tggcgtggtg aaccgggaac
     6241 aaaagatgaa cctcagcata aaaaacaggg tgaggtaact ttagatttgt tgaaagcaat
     6301 gcggattcct tatataattc ttgattcaaa tgagaatgat gcatttattc agctccatga
     6361 tatcatacaa tcagcaaaaa ctaagaatat tcctcatgca ataattattc ggaaagatgt
     6421 ttttggcaaa tataaacttc aaaaagagtt cggatgtaat tatcctttat ctcgtgagga
     6481 tgctttgcaa atagttgtgg attatctgcc tgaaaattca gtggtcgttt ctactactgg
     6541 caagctttct cgtgagttat ttgaatatcg agaaatgaaa gagcaaggtc atgaacatga
     6601 ttttctcacg gtaggctcta tgggacatag ttcatcaatc tctttgggta ttgctatagc
     6661 aaagcaagat agacctgttt attgcttgga tggtgatgga gcatttatta tgcatttagg
     6721 ggcaattagt aacattggcg atttatctcc taaaaactat tatcatattt tgtttaacaa
     6781 tggtgctcac gagtctgtag gaggacagcc tactttagga tttagtttag atattccggc
     6841 tattgtccgg gggagcggat ataagcatac ttatactgtt tgtacaaaag ttgaaattga
     6901 agaagcaatg aagcagcttc caaagttatg tggtcctgtt ttgttggaaa taaaggttaa
     6961 aatagattct cgggagaatt tgggacgtcc cacgactact cctatagaga ataaggagca
     7021 ttttatggat tttttaaaat aaatatattc gatgaaaata gaaagaaaaa tattattaaa
     7081 tcctgggcct gccactacta ctgacagtgt aaaaatggca caagttgttc cggatatttg
     7141 tcctcgcgag aaagaattcg caggtatgat gaaacaactt cgggacgatt tggtcagagt
     7201 tgctcatggg aatttggaaa aacataccgc tgtattattt tgtggctcag gaaccatcaa
     7261 tattgatata tgtctaaatt ctcttcttcc tgaagacaaa agggtgctta tagtgaataa
     7321 tggggcatat agtacccgtg ctgtagaagt gtgtcaatat tatggtttgc ctcatattaa
     7381 tttggaattt tccgtttacg aacgtcctga tttatcggtg gtggaaaatg tgttgcaaga
     7441 aaatcctgat atagctatgg tttatactac tcatcacgag acgggtacag gaattctgaa
     7501 ccctattcgc gagatgggcg ctatagctca taaatatcag gctaaatttg tcgtcgatac
     7561 tacttcttct ttgggcatga ttccttttga tatagagaaa gataatgtgg atttttgtat
     7621 ggcatctgct caaaaaggac ttcaagcgat gacaggtctt tcttttatta taggcaatga
     7681 ggaacagatt aagttttcaa aaaaatatcc caagcgttct tactattgta atctttattt
     7741 gcagtatgag aattttgaga gaacaggtga aatgcatttt actccaccgg tacaaactat
     7801 ttacgccact cgtcaggcat taaatgaata ttttgaagtg ggtgaagaag ctaagtttgc
     7861 ccgtcacaaa agagtttttg aggctattca ttcaggtata aatgaaattg gtcttaaaag
     7921 tgtaataaag cgtgaatggc agtcaggact ggttgtctca gttcaatacc cagaagatcc
     7981 caactgggat tttgagaaaa tacatgatta ttgttatgag cgtggattta cgatttatcc
     8041 aggtaagata tcaactgagg atacttttag aatctgtgct ttaggagaga tagaagtaga
     8101 tgatattgag aacttcttta aagtactaaa agctgcatta aatcattata acgtcacatt
     8161 accgatgtca tgattgcaga aatattattg aagattcgtc atttttattt ttcccttcgt
     8221 ggtatacact tccatccgga aagtgttatt tctggagtgc ctattcgtag ctttcgctta
     8281 gtaggcaaat atggcaatat taatttgagg tgatgcatta ggagttcttt attcttataa
     8341 aaaggcatcg gtagttatag gagataatgt ttgtgtaggg taatttgctt ttagtgggag
     8401 agaccatatt agaattgcgg taaggggcga agaagataat aaccaattag tgagaatatt
     8461 ggaaaaatat aattgatatc ggtaaatgta gttgttttta tactgtattt aagtaatgga
     8521 aaatctaaag cagaaaactg tatcaggaat aatgtggagc gctatagaac gtttctcttt
     8581 acaaggagta cagtttataa ttcaaataat attagctcgt ttgttactac catcggatta
     8641 tggtatgatc gggatgttag ctatttttct tcaagtcgct caagtattta tagatagcgg
     8701 ttttacaaat gctttaatcc agaaaaaaga tagaactgaa gaggattttg ccactgtctt
     8761 ttattttaat attcttgtcg cagtattatt ctatggtata ttgttttttt cggcttcttt
     8821 gattgcagac ttttataata tgccgacttt agttcttgta attcgtttta tagcattgtc
     8881 gttgataata aatgctttat cggctattca cagaacgaaa ttaattattt ctgtaaactt
     8941 taaaactcaa tctaaaattt cattaggtgc agcttttata tcaggcgtga ttggaatatg
     9001 gatggcttat gtcggttgcg gggtttgggc tttagtttgg caaactctct taaatagtat
     9061 aattttgaca attttgtttt actgtttagt tcattggaaa cctttacata ctttctccaa
     9121 aagttctttt gaaagattat tcaatttcgg atctaaatta ttgatctcaa gtcttatcaa
     9181 tacagtatat cgtaatctgt ataccattgt aataggaaaa aagttttctg ttgtagagct
     9241 tggttactat acaagagcag aacaatttgc tatttttcct tccaataatt taaatgcttt
     9301 agtttctaga gtagcgtatc ctattttaag ttccattcaa gatgatgata aatgtttaac
     9361 aaacgcatat cgaaattata tcagattatc ctcatatata atttttcctt taatggtagg
     9421 tttacttgtt ttggctaatc ctattattag tctattgtta acagataaat ggtctggggt
     9481 tgttattctt ttacagatat tatgtttgga ttggatgttt gatcatttga gccaaattaa
     9541 tttgaattta ttatgggtta aaggaagatc tgatctgtcg ttacgtcttg aaataataaa
     9601 aaagacgatt gctatattca ttctttttgt gtcaattcca tttgggcttg aggtgatgtg
     9661 ttggggtaga gttatttact ctctgatagc gacatatttg aatacatatt atactaattc
     9721 tcttattgat ttgaccttaa agttgcaagt taaagatgta tttccaagtt taatactctc
     9781 tttcataatg ggggggatcg tttttatatg tatttctttc tttgaaactg atatagtaaa
     9841 aattgtgatt ggatgtatta ctgggatgtc cttctatatt ttactttctt ttctttttaa
     9901 gctagattct tttttttgta ttttaacatt gatcattaaa actaaaaaca tagatgaaaa
     9961 tattaaaaaa gatttttcaa gtaatagtaa agataattaa ccattgtgtg ccagttgata
    10021 gtagatcatt gtattttatt cctcatccta attgtagaac agataaatat gatattataa
    10081 attattcgtc agataatgtt ctcgttctgt taaattattt gctaaaaaaa gatagtgctg
    10141 aatattataa aatatatgtt gaaatttatg attcttctcg tatttcagaa tatcaagaat
    10201 atatttatgg cataaatcct aatattaggt gtactttttt atgtgcatgt gttggacgtt
    10261 ttttctttaa taaagtatct tttaaggata tgttgtatgc ctttttttgt ttttgtagag
    10321 caagtaaatg ttttacagct actttttatt atgatttttc atttaaaaaa cgctctcaac
    10381 agattatttg tttggggtat tatactccat tcaaagatga ttatcatatg ggagatcatt
    10441 cttatgataa atttcgtaat acaacatgta actcatttga ttactctatt gctacttctt
    10501 gtttaagtgc tagaataatt tcaatagatt gtggaatctc atatgataaa ttcaaagtct
    10561 taggatttcc cagaaatgat ttgttgatat cgaaaaataa ttgcaatgtt attaaaagag
    10621 aaatttcgaa atttgcggga tatgatgtaa ctaaatatat agtttatact ccaacttttc
    10681 gtgattatga gactgttact gaaggtaatt tgcgttcaat actcggatat gttgattgtg
    10741 atttgttgaa gttatcgaaa atactattga agtttaatgc ggctttaatt cttaaattac
    10801 atcctttgca gaataaaaca gtcttaaaaa aagatttacc caaaggtata cttgtttttg
    10861 aacaaacata taaatatgga ttgtatgatc ttttgtcatt ttcagatgga atgattactg
    10921 attatacttc tacctatttt gattttttat tggtaaataa gccagtcata tttaatttct
    10981 acgatattga agaatatcgt agagtaagag gtttctcatt tgagccaata gaattttttt
    11041 gtgcaggtga tattgtttac aattataatg aattgataga tgctgtgatg ggacttctgg
    11101 ctgggaaaga tattcatgct gaacatcgac gtcatatttc tttattgatg aatcaatttc
    11161 aagatgataa ttcaacaaag agaatatgtg acatattttt aaatgaaata taataaataa
    11221 aatgaattat gcatttgtgg tgcaggcacg tttaggttct acacgtttgc ctggaaaaat
    11281 attgaaacct ttctatggta atcaatcgat tcttgactta atggttcata agctttctgc
    11341 tatatcgaat attccagtaa ttattgctac aacaaattct gttatcaatg aacctattga
    11401 aaagaaggca cttgcattag gggtaaagtg cttcagaggt gaggagaatg atgttttaaa
    11461 acgattcatt gatgttgctg aatattttga tatacagggt atattccgaa tatgttctga
    11521 taatccattt ttagatgtac atgcggcaag gcaattggtc gaaatagcaa tgaaatcttg
    11581 taacgattat ataagttttg atattgatgg tactccatca attaaaactc atttcggttt
    11641 ttggggagaa tttgtaacgc ttgatgcgct gaagcgagtt ataggattta ctgatgattt
    11701 attgtatcgt gaacatgtta ctaattatat atatagtcat cctgaacttt ttaatattca
    11761 atggatttca ggatctccag tcgtgtcaaa acatcataat attcgactca cgattgatac
    11821 gttagaagat ttttctgtag cacagagaat atatagggat ttacaagaaa aaagagtgga
    11881 aatatcgata gaagtgattg tagactatgt tcgaagacat gcagaataca ttcaactgat
    11941 gaaacaacaa ataaaaaaaa aattctaaat aatgaagaat acttatatta ttggtgaaat
    12001 agggcagaat cataatggtt ctgttgactt ggctaagttg attattgaat taatctcacg
    12061 acctgtacat gaggatgttt ttggtatgga tttcatgcca atgaatgctg ttaaaatgac
    12121 taaaagagat ttatcagaag aattggctgt ttctcaaatg aatcaaatat atgacaatcc
    12181 taattctttt gggcgtactt atggtgaaca tcgtgctttt cttgagcttg atgatcaagc
    12241 gcattttgag atttataaat atgctaagtc attaggatta gattttatcg agacgttatg
    12301 tgccaaagga tgtctgtctt tgcttaaact gttcacaccg gataggctaa aagttgctag
    12361 tcgtgatttg actaacttac cattgcttga agcattagca gaaactcata ttcctattat
    12421 attatcgaca ggaatggctg gtcaaagaga acttgacaat gcattagatg tgataacgag
    12481 atatcatagt aatatagcta ttctacattg tgtatctcag tatccaactc atccaaataa
    12541 tttgaatcta cgtacaataa catatttgaa gaagcattac aataagtttg agataggttt
    12601 ttctgatcat acaataggta tttctgctgc tacagctgct gtagcgatgg gagcggaaat
    12661 tatagaaaag catgtaacaa ttgatcggca tatgaaagga acagaccagc ttggctcttt
    12721 aggtccagat ggggttaatc gtatgattcg agatattcgc atagcagagt gttggcttgg
    12781 tactgaagat ctttatatag aaaaaggggt ggagaagtct aagataaaac ttgaacgttc
    12841 tattgccact cgaaaatata ttccagcagg tagtattatt caagagtcgg acattcattt
    12901 actgagtcct ggtgatggtt ataaatggat agataaaaaa aatgtaattg gtcattttgc
    12961 taaacaagat atatcagcga atgaaataat atatcctgat tttattgaat agatatattc
    13021 ctactgcaac ttgtattacg gtatagagta ctgcctgcta taagctaagt agtgattaat
    13081 aaataagggt aaaatactaa aaaaatgaaa gagataaagc ttatacttac agatattgat
    13141 ggcgtttgga ctgatggcgg aatgttttat gat
//
