LOCUS       c00122_gnlPro..        12053 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|DIFEPDJN_122.
ACCESSION   c00122_gnlPro..
VERSION     c00122_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-07 06:39:48
            Original ID  :: gnl|Prokka|DIFEPDJN_122
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 12053
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12053
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[2861:8946]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      2862..8946
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..12053
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..12053
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             complement(2..772)
                     /locus_tag="ctg122_1"
                     /transl_table=11
                     /translation="MVYDLTMLKTFYAAYSEKIERVRNVLRRPMTLAEKILYAHLYDGD
                     KVKNYRRGEDYVNFRPDRVAMQDATAQMALLQFMNAGREQVAVPSTVHCDHLIQAYKGA
                     KEDVATATKTNEEVYNFLRDVSSRYGIGFWQPGAGIIHQVVLENYAFPGGMMVGTDSHT
                     PNAGGLGMVAIGVGGADAVDVMTGMEWELKMPRLIGVHLKGKLSGWVAPKDVILKLAGI
                     LTVKGGTNAIIEYFGPGTASLSATGKATICNMGAE"
     CDS             887..2800
                     /locus_tag="ctg122_2"
                     /transl_table=11
                     /translation="MITFATMKEQDSNSPIIHLQQQQLLLRMEYEYEKEEFKRQTENMG
                     VARKVKRGLCWYPATPGRSYYNSLNQLVIEITHTENTDIEHNFEFGRPVCFFRQSADGK
                     ITYMNFTATVSYADETRMVAIMPGAGAVMEVQETDNLGVQLYFDETSYRTMFEALEDTL
                     RSKGNRLAELRDILLGTSKAGFRELYPVRFPWLNSTQETAVNKVLCARDVAIVHGPPGT
                     GKTTTLVEAIYETLHREPQVLVCAQSNTAVDWISEKLVDRGVNVLRIGNPTRVNDKMLS
                     FTYERRFENHPLYPELWSIRKNLRELGSRARRGSYDEREGVRSRMSRLRDRATALEIQI
                     NSELFDGAHVIASTLVSSNHRLLNGRRFGTLFIDEAAQALEAACWIAIRKADRVVLAGD
                     HCQLPPTIKCHEAARGGLERTLMEKVVSNKPAVVSLLKVQYRMHEEIMKFPSQWFYNGE
                     LEAAPEVRYRGILDWDTPIHWIDTSEMDFKEEFVGETFGRINKAEADLLLSELKIYINR
                     IGGSRILEEKIDFGIISPYKAQVQYLRNKIKADASLKPYRSLFTVNTVDGFQGQERDVI
                     FISLVRANEEGQIGFLNDLRRMNVAITRARMKLVILGEAETLKHHGFYRKLLEFIQNIG
                     NQ"
     CDS             complement(2862..3905)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: IlvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg122_3"
                     /sec_met_domain="IlvN (E-value: 4.2e-47, bitscore: 149.2,
                     seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="IlvC (E-value: 3.5e-41, bitscore: 130.3,
                     seeds: 295, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAQLNFGGVIENVMTREEFPLEKAREILKDETIAVIGYGVQGPGQ
                     ACNLRDNGFNVIVGQRPGKTYEKAVADGWVLGETLFGIEEACQKGTIVMCLLSDAAVMS
                     VWPTIKPYLTPGKALYFSHGFAITWNDRTGVVPPKDIDVIMVAPKGSGTSLRTMFLEGR
                     GLNSSYAVYQDATGKAFDKTIALGIGIGSGYLFETTFIREATSDLTGERGSLMGAIQGL
                     LLAQYEVLRENGHTPSEAFNETVEELTQSLMPLFAKNGMDWMYANCSTTAQRGALDWMT
                     PFHDAIKPVVQKLYASVKSGNEAQISIDSNSKPDYREKLNAELKALRESEMWQTAVTVR
                     KLRPENN"
     CDS             complement(3956..4708)
                     /locus_tag="ctg122_4"
                     /transl_table=11
                     /translation="MMSENNKIGTYKFVAEPFHVDFTGRLTMGVLGNHLLNCAGFHASD
                     RGFGIATLNEDNYTWVLSRLAVELDEMPYQYEDFSIQTWVENVYRLFTDRNFAIIDKEG
                     KKIGYARSVWAMISMNTRKPADLLALHSGSIVDYVCDEPCPIEKPSRIKVASKEPVAAL
                     VAKYSDIDINGHVNSIRYIEHILDLFPIEMYKEKRIRRFEMAYIAESYYGDELTLFMDD
                     AGEGVYDVEVKKNGSEVVCRSKVIFTEK"
     CDS             complement(4705..5265)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg122_5"
                     /sec_met_domain="ALS_ss_C (E-value: 6.1e-20, bitscore:
                     60.8, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKKLYTIIVHSENFAGLLNQVTAVFTRRQINIESLNVSASSIKG
                     VHKYTITAWTDKDTIEKVTKQITKKIDVLQAHYFTDDEIYQHEIALYKITTPTLEEKPE
                     VSKVIRKYNARIVEVNAVFAIVEKNGMSEEITNLYEELRQLDCVLQFVRSGRVAITTSC
                     FERVNEYLADREAKYRQSKHQES"
     CDS             complement(5298..7049)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg122_6"
                     /sec_met_domain="TPP_enzyme_C (E-value: 8.5e-48, bitscore:
                     151.4, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MADNNKKSNFSSLSQGEGRGEALITGAEALMRSLEHQGVKTIFGY
                     PGGSIMPVFDALYDHRKELNHILVRHEQGATHAVQGFARVSGEVGVCLVTSGPGATNTI
                     TGIADAMIDSTPIVVIAGQVGTNFLGTDAFQEVDLVGITQPITKWSYQIRRAEDVAWAV
                     ARAFYVAKSGRPGPVVLDFAKNAQVEKTEYAPTKVDYVRSYLPVPEMEPEAIRKAAELI
                     NGAERPLVLVGQGVELGEAQQELRAFIEKAGMPAGCTLLGLSALPTNHPLNKGMLGMHG
                     NLGPNINTNKCDVLIAVGMRFDDRVTGKLETYAKQAKIIHFDIDPAEIDKNVKTDVAVL
                     GDCKETLAAVTQLLEPANHQEWIDSFRQYEEVEEEKVIRPELHPAGKALSMGEVVRAVS
                     EATHNEAILVTDVGQNQMMSARYFKYSKERSIVTSGGLGTMGFGLPAAIGATFGRPDRT
                     VCVFMGDGGLQMNLQELGTIMEQKAPVKMILLNNNFLGNVRQWQAMFFNRRYSFTPMMN
                     PDYMKIASAYDIPARRVMTREELAKAIDEMIATDGPFLLEACVEEEGNVMPMTPPGGSV
                     NQMLLEC"
     CDS             complement(7141..8946)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ILVD_EDD"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg122_7"
                     /sec_met_domain="ILVD_EDD (E-value: 2.8e-216, bitscore:
                     708.4, seeds: 918, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKHQLRSSFSTQGRRMAGARALWTANGMKKEQMGKPIIAIVNSFT
                     QFVPGHVHLHEIGXXXXKEEIEKLGCFAAEFNTIAIDDGIAMGHDGMLYSLPSRDIIAD
                     SVEYMVNAHKADAMVCISNCDKITPGMLMAAMRLNIPTVFVSGGPMEAGEWNGQHLDLI
                     DAMIKSADESVGDKEVAQIEQHACPTCGCCSGMFTANSMNCLNEAIGLALPGNGTIVAT
                     HENRKKLFEDAARLIVENAFRYYEEGDESVLPRSIATREAFLNAMTLDIAMGGSTNTVL
                     HLLAVAHEAGADFKMDDIDMLSRKTPCLCKVAPNTQKYHVQDVNRAGGIIAIMDELAKG
                     GLVDTNVRRVDGMTLAEAIDRYSITSSNVCKEAIKKYSSAAAGKFNLVLGSQNASYKEL
                     DTDRATGCIRDLEHAYSKDGGLAVLKGNIAQDGCVVKTAGVDESIWKFTGPAKVFDSQD
                     AACDGILGGKVVSGDVVVITHEGPKGGPGMQEMLYPTSYIKSRHLGKECALITDGRFSG
                     GTSGLSIGHVSPEAAAGGNIGKIKDGDIIEIDIPNRSINVKLTDEELAARLMTPVTRNR
                     EVSKALKAYASMVSSADKGAVRLID"
     CDS             9436..10008
                     /locus_tag="ctg122_8"
                     /transl_table=11
                     /translation="METVENKYITVAYKLYSIENGEKDFEEEAPVEHPFQFISGLGMTL
                     EPFEAQIKDLQIGDKFDFTIPASEAYGEYDDDHVIDLPKEIFMIEGEFDSDRVVEGAVI
                     PLMTSEGQRINGSVVEVKEDIVVMDMNHPLAGCDLNFTGEVVESRLATNEELAEVARMM
                     GGGCGSCGCGDCGDGCGDHECGGGCCH"
     CDS             complement(10108..11388)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) SDH_alpha"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg122_9"
                     /sec_met_domain="SDH_alpha (E-value: 1.8e-62, bitscore:
                     200.7, seeds: 645, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTKTERQQIIDLVKSEVVPAIGCTEPIAVALCVAKAAEVLGRHPE
                     KITVLLSANILKNAMGVGIPGTGMIGLPIAVALGALIGKSEYQLEVLKDCNPDAVEEGR
                     RFIDEKRIHIALKDGIKEKLYVEVCCEVGDEKSTAIIAGGHTSFVYMARNGEVLLNKQA
                     VASTEKEEGALDLSLRKVYDFALTAPLDEIRFILETARLNKAAAESSFEGDYGHGLGKI
                     LRGTYEHKVMGDSVFSHILSYTSGACDARMAGAMIPVMSNSGSGNQGISATLPVLIYAE
                     ENGKSEEELIRALMLSHLTVIYIKQSLGRLSALCGCVVAATGSSCGITWLMGGTYEQVA
                     YAVQNMIANLTGMICDGAKPSCALKVTTGVSTAVLSAIMAMENRCVTSVEGIIDEDVDQ
                     SIRNLTKIGSKGMNETDKLVLEIMTSK"
     CDS             complement(11535..12053)
                     /locus_tag="ctg122_10"
                     /transl_table=11
                     /translation="AIQMGSVILPQVLQDVTLSADGNIVATYSSAGIDLSGEKPITPVW
                     ETSPADYATFKLQGNGKMLLFLNLEKIIADANTKADITTVISQLLELVKNGIPVNYALS
                     NNNEEVKIFIDKELMTTIAAMGPAIAELIPDDPDALGSFGPMIKAILGDLPTAMSKTTK
                     FELGLNLKK"
ORIGIN
        1 cctctgcccc catattgcag atggtagcct ttccagtggc agacaatgaa gcggttcccg
       61 gtccaaaata ttcaatgatg gcattggttc ccccttttac agtaagaata cccgccaact
      121 tcagaataac gtctttggga gctacccagc cactcaattt acccttcaag tgtacgccta
      181 tcagacgcgg cattttcagt tcccattcca tgccggtcat cacatccacc gcatcggcac
      241 cacccacacc aatggccacc atgcccaaac ctccggcatt gggcgtatga gagtccgtgc
      301 ctaccatcat tccacccgga aatgcgtagt tctccaatac cacctggtga ataatgcctg
      361 cccccggctg ccaaaaacct ataccatagc gggaagaaac atcacggaga aaattataga
      421 cctcctcgtt ggtcttcgta gcagtcgcaa catcttcttt tgcaccttta tatgcttgaa
      481 tcaaatggtc acaatgcaca gtggaaggca cggcaacctg ctcacggcct gcattcataa
      541 attgcaataa ggccatttga gccgttgcat cctgcatggc cacacggtcg ggacggaaat
      601 tcacatagtc ttctccccgt ctgtagttct tcactttatc cccatcatac aaatgagcat
      661 acaaaatttt ctctgctaaa gtcatcggac gccgcagtac gttccgtacg cgttctatct
      721 tctccgaata agcggcataa aacgttttga gcatcgttaa atcatatacc ataaccacta
      781 ttttttagtt tttcattatt gtaaagatta caaattaata tcataaacaa ataaaaaggc
      841 tgaatagttt aacaaaataa agcatttttt ctgtcggaag cgaagaatga ttacctttgc
      901 aaccatgaag gaacaagatt caaatagtcc tattattcac ctccagcagc aacaactttt
      961 gctgcgcatg gaatacgaat acgaaaaaga ggaattcaaa cgccaaaccg aaaacatggg
     1021 agttgcccgg aaagtgaaac ggggactttg ctggtatcct gccactccgg gacgaagtta
     1081 ctataattca ctgaatcaat tagtaataga aattacacac acagaaaata ccgatataga
     1141 acataatttt gagttcggcc gtcccgtatg ttttttccgc cagtctgccg atggaaaaat
     1201 aacctatatg aacttcaccg ctaccgtaag ctatgccgac gagacacgga tggtagcgat
     1261 aatgcccgga gccggtgccg ttatggaagt gcaggaaacg gacaacctcg gcgtgcaact
     1321 ttatttcgac gaaacatcct atcggaccat gttcgaagcc ttggaagata cgttacgctc
     1381 caaaggcaac cgcctggccg aattgcggga catattgctg ggaacctcga aagccggttt
     1441 ccgagagctc taccccgtac ggtttccctg gctgaactcc acgcaggaga cagctgtaaa
     1501 caaagtgctg tgtgcccgcg acgtggccat tgtacatggt cctccgggaa ccggaaaaac
     1561 gaccacctta gtggaagcca tctacgaaac cctgcatcgg gaaccgcagg tactagtatg
     1621 tgcccaaagc aatactgccg tcgactggat ttcggaaaaa cttgtggacc gtggcgtcaa
     1681 tgtcctgcgt atcggcaatc cgacccgtgt caacgacaag atgctttcct ttacctacga
     1741 gcgtcgtttc gagaaccatc cgctttatcc ggaactgtgg agcatccgga aaaatctccg
     1801 tgaactgggc agccgtgccc gccgtggcag ctatgacgaa cgcgaaggag tacgcagccg
     1861 tatgagccgc ctgcgcgacc gcgccaccgc attggaaata caaatcaatt cagagctttt
     1921 tgatggggca cacgtcatag cctccacgct ggtaagcagc aatcaccggc tgctgaacgg
     1981 acgccgtttc ggcacccttt tcattgatga agcagcccag gccttagagg ctgcctgctg
     2041 gatagctatc cgaaaagcag accgcgtggt attggcgggt gaccactgcc aacttccgcc
     2101 caccataaaa tgccacgaag ccgcccgtgg aggtctggaa cgaacattga tggagaaagt
     2161 ggtgtccaac aaacctgccg ttgtctcttt gctgaaagtg caataccgca tgcacgagga
     2221 aatcatgaaa tttccttccc aatggtttta taatggcgag ttggaagccg ctcccgaagt
     2281 gcgttaccgg ggcatcctgg actgggatac ccctatccac tggattgaca cctccgaaat
     2341 ggatttcaaa gaagaatttg tgggagagac tttcggacgc atcaataaag cggaagcgga
     2401 cctgctccta tcagaactga aaatctacat caaccgtatc ggtggcagcc gcattctgga
     2461 agaaaaaata gacttcggca tcatctcccc ttacaaggca caagtgcaat atctccgcaa
     2521 caagataaag gcagacgctt cactcaagcc ttatcgcagc ttgttcactg taaatacggt
     2581 ggatggcttc caagggcaag agcgcgatgt tatcttcatc agccttgtcc gcgccaacga
     2641 agaagggcag ataggattcc tgaatgattt aaggagaatg aatgtagcca tcacccgggc
     2701 acgtatgaag ctggtgatat tgggagaggc agagacgctg aaacatcacg gtttttaccg
     2761 gaagctattg gagtttattc aaaatatagg gaatcaataa taaagaaata ccccctccgg
     2821 taacaccgaa gagggtattt cacctattta tataaagctg attaattgtt ttccggacga
     2881 agtttacgaa ctgtaacagc tgtctgccac atttcgcttt cacgcaaggc tttcaattct
     2941 gcattcagct tctcacgata atcgggtttg gagttgctgt cgatagaaat ctgagcttcg
     3001 ttacccgact tcacgcttgc atacaatttc tgtacaaccg gcttgatggc atcatggaac
     3061 ggggtcatcc aatccagcgc accacgctgt gccgtagtag aacagttggc atacatccag
     3121 tccataccat tcttggcaaa caatggcatc aaagattgag tcaactcttc cacagtttca
     3181 ttgaatgctt cagaaggagt gtgaccgttt tcgcgcaata cttcatactg agccaacagc
     3241 aatccctgga tagcacccat caatgaaccg cgttcaccgg tcaagtcgga agtggcttcg
     3301 cggatgaaag ttgtctcgaa caaatatccc gaaccgatac cgatacccag tgcaatcgtc
     3361 ttgtcaaaag ccttacccgt agcatcctga tagacggcat atgatgagtt caagccacgc
     3421 ccttcgagga acatggtacg aagtgaagta ccggaacctt tgggagcaac cataataaca
     3481 tcaatatctt taggaggaac cacgccggta cggtcgttcc aggtaatagc aaaaccatga
     3541 gagaagtaaa gagcctttcc gggagtcaaa taaggtttga tagtcggcca tacagacatt
     3601 acagctgcgt cagacaacag acacatgacg atagtacctt tctgacaagc ctcttcgatg
     3661 ccgaacaaag tctcacccag tacccatccg tcagccacag ccttttcgta tgtcttaccc
     3721 ggacgttgtc ctacaatcac attgaaaccg ttatcacgca agttgcaagc ctggcccggg
     3781 ccttgtacgc cataaccgat tactgcaatt gtttcatctt tcaaaatctc acgtgctttt
     3841 tccaaaggaa attcttcgcg ggtcattaca ttctcaataa caccgccaaa attcaattgt
     3901 gccatttttt gttttaattt ttatttgtgg cttacgccaa cgttgataaa tttatttatt
     3961 tctctgtaaa tatcacttta gagcgacaga ccacttcgct gccattcttt ttcacctcca
     4021 catcgtaaac gccctcaccg gcatcatcca tgaacaaagt caactcatcc ccataatagc
     4081 tttcggctat atatgccatt tcaaaacgac ggatgcgctt ctccttatac atctctatcg
     4141 ggaacaaatc aaggatatgc tcgatgtaac ggatgctgtt cacatgcccg ttaatgtcaa
     4201 tatcactgta tttggctacc aaagcagcaa ccggttcctt tgaggccacc tttatccgcg
     4261 aaggtttttc tatcgggcaa ggctcatcgc aaacataatc tacaatgctg ccactatgaa
     4321 gagccagcaa atctgccggc ttacgggtat tcatgctaat catcgcccaa acggaacgtg
     4381 catacccaat cttcttaccc tccttatcga tgatagcgaa attacggtct gtaaaaaggc
     4441 gatagacatt ctccacccaa gtctgaatgg agaaatcttc gtactgataa ggcatttcat
     4501 ccagttcgac agccagacgg gacaataccc aagtataatt gtcctcgttt agagtcgcga
     4561 tgccaaaacc gcggtcgctg gcatggaaac ccgcacaatt caacaaatgg ttgcccaata
     4621 ctcccattgt cagccgtccg gtaaagtcga catgaaacgg ttcggcaaca aacttgtagg
     4681 tacctatctt attgttctcg ctcatcatga ttcctggtgt ttactttgac gatattttgc
     4741 ttcacggtcc gccagatatt cattgacacg ctcaaagcag ctggtcgtaa tggctacgcg
     4801 acccgaacgg acgaactgaa gtacgcaatc caactggcgc aactcctcat aaagattggt
     4861 tatttcctca ctcatgccat tcttctcaac aatggcaaat acagcattca cctccacaat
     4921 acgggcattg tacttacgga ttactttgga cacctccggt ttttcttcca gcgtaggggt
     4981 cgttatttta taaagggcaa tctcgtgctg atagatttca tcatccgtga aataatgggc
     5041 ttgcagcaca tctattttct tggtaatctg cttggtcacc ttttcaatgg tatccttgtc
     5101 cgtccaagcg gtaatggtat atttatgtac ccccttgatg gaggaggccg atacattcaa
     5161 actctcgatg tttatctgcc ggcgggtaaa cacagccgtc acctgattca gcaaaccggc
     5221 aaagttttcc gaatgaacaa tgattgtata tagtttttta tccatagata gagtaagttc
     5281 tttaatttcg catgacttca gcattccaac aacatctgat tgaccgaacc gcccggaggt
     5341 gtcatcggca ttacatttcc ttcttcctcc acacaagctt cgagcaggaa cggtccgtca
     5401 gtcgctatca tctcgtcaat cgcttttgcc agctcctcgc gggtcattac cctgcgtgca
     5461 ggaatatcat atgccgaagc aatcttcata taatccggat tcatcatcgg agtaaacgaa
     5521 taacgacgat tgaagaacat cgcctgccat tgacgaacat tgcccaggaa gttattgttc
     5581 aacagaatca tcttcaccgg agccttttgt tccatgatgg tacccagttc ctgcaggttc
     5641 atctgcaagc cgccgtctcc catgaatacg cataccgtgc ggtccggacg tccaaaagtg
     5701 gcaccgatag ctgccggaag gccgaagccc atagtaccca ggccaccgga agtaacaatg
     5761 ctacgttcct tgctgtattt gaaataacgg gcggacatca tctgattctg gccgacatca
     5821 gtcaccaata tcgcctcgtt atgggtagcc tcactcacag cacgcaccac ctcacccatg
     5881 cttagcgctt ttcctgccgg atgtaattcc ggacggatta ccttttcctc ttccacttcc
     5941 tcgtattgcc ggaaactgtc aatccattcc tgatggttgg cgggttccag caattgggta
     6001 acggcagcca gtgtctcttt gcaatctccc aggacagcaa catcggtctt tacattctta
     6061 tctatttcgg cagggtcaat atcaaagtgg ataatcttcg cctgcttggc atatgtttcc
     6121 aatttacccg tcacacggtc atcaaagcgc atgcctacgg cgataaggac atcacattta
     6181 ttggtattga tattgggccc caggttaccg tgcataccaa gcattccttt gttcaacgga
     6241 tggttcgtag gtaatgcgga aagtcccaat aaagtgcatc cggcaggcat tccggctttc
     6301 tcaatgaaag cacgaagctc ttgctgggct tctcccagct ccacgccttg tcctaccagc
     6361 accaaaggcc gttccgcacc atttattaat tcagcagcct tccgtatggc ctccggctcc
     6421 atttcgggaa cgggaagata gctacggaca tagtccacct tagtaggcgc atattctgtt
     6481 ttctccactt gggcgttttt agcaaaatcc agcacgaccg gtcccggacg tccgctcttt
     6541 gccacataga aagcacgtgc cactgcccag gccacatctt ctgcacgacg aatctggtaa
     6601 ctccatttcg tgataggctg agtaatgcct accaagtcca cttcctgaaa tgcatccgta
     6661 cccaagaagt tcgtccctac ctggccggca atgacaacga taggcgtact gtcaatcatg
     6721 gcatctgcaa tgcccgtgat agtattggta gcacccggtc cactggtaac cagacaaacg
     6781 ccaacctcgc ctgatacacg tgcaaagcct tgtaccgcat gggttgctcc ttgttcatgg
     6841 cgaaccaaga tgtggttcaa ttccttccgg tggtcgtata aggcatcgaa taccggcatg
     6901 atgctccctc ccggataacc gaaaatagtc tttactccct gatgctccag agagcgcatc
     6961 aatgcttctg cgcctgttat tagagcctca ccccgaccct ctccttggga gagggaggaa
     7021 aagttactct ttttattatt atcagccata ctttatctat tcattatatt taaaagctca
     7081 atagtagctt gaaaaatttg tttcattctc tcctcccctc gctttcggaa aggggggctt
     7141 ttaatcaatc agcctcacag cccctttgtc agcggaactc accatactgg catatgcttt
     7201 caatgctttg gagacttcac ggttgcgggt taccggagtc ataaggcgtg ctgcaagctc
     7261 ttcatccgtc aacttcacat tgatagaacg gttcggtata tcaatttcga taatgtcccc
     7321 atccttaatc ttgccgatat taccaccggc agccgcttcg ggagaaacat gtccgatact
     7381 tagtccggaa gtaccaccac tgaaacgccc gtcggtaatc aatgcacact ccttacccag
     7441 atggcgggat ttgatataag aagtaggata aagcatctct tgcatacccg gtccaccttt
     7501 cggcccttcg tgagtgatga cgacgacgtc tccactgacc acctttccac ccagaatacc
     7561 gtcacaagcc gcatcttgtg agtcgaagac tttcgctggc cccgtaaatt tccagatact
     7621 ctcgtctaca cccgcagtct tgacaacgca accgtcctga gctatatttc ccttcaaaac
     7681 cgccagaccg ccatccttgc tgtatgcatg ttccaaatca cggatacaac cggtcgcacg
     7741 gtccgtatcg agttccttat aagacgcatt ttgtgagccg agtaccagat tgaactttcc
     7801 ggctgccgca ctggagtatt tcttgattgc ctctttacat acattagagc tggtaatact
     7861 ataccggtcg attgcctctg ccaacgtcat tccatccaca cggcggacat tcgtatcgac
     7921 caatccgccc ttggcaagct catccatgat ggcaatgatg ccaccggcac ggttaacgtc
     7981 ttgtacatga tacttttggg tattgggagc caccttgcat aagcaggggg tcttgcggga
     8041 gagcatgtca atatcgtcca tcttaaaatc cgctccggct tcgtgagcca cagccaacaa
     8101 atgaagtacc gtattagtgg aaccgcccat cgcaatatcc agcgtcatgg cattcaaaaa
     8161 tgcctcgcgg gtagcaatac tgcgcgggag tacactctca tccccttctt cataatatct
     8221 aaaggcattc tctacaatca acctggctgc atcctcaaat agtttcttgc gattttcgtg
     8281 agtggctaca atcgtgccgt taccgggcag tgccaatcca atcgcttcat tcaagcaatt
     8341 catggaatta gcggtaaaca tgcctgagca gcatccgcaa gtggggcagg catgttgctc
     8401 aatctgtgcc acctctttat cgcccacact ttcatcagca gatttaatca tggcatcaat
     8461 caaatccaaa tgctgtccgt tccattcccc ggcttccatc ggaccgcctg aaacaaacac
     8521 agtcggtata ttcagcctca tagccgccat cagcatcccc ggagtaatct tgtcacagtt
     8581 actgatgcaa accatagcat ctgccttatg ggcatttacc atatactcca cactatcggc
     8641 aatgatatct cttgaaggca gggaataaag cataccgtcg tgtcccatag cgataccgtc
     8701 gtcaatggca atcgtattga actccgcagc aaaacacccc agtttttcaa tctcttcctt
     8761 tnnnnnnnnn nggcctattt cgtgcaggtg tacatgcccg gggacgaatt gtgtaaatga
     8821 attgactata gcgataatgg gcttacccat ctgttccttc ttcataccat tcgccgtcca
     8881 caatgcacgg gctcccgcca tgcggcgacc ttgtgtgctg aacgagctgc gtaactgatg
     8941 cttcattttc aaatctcctt ttaatgaaaa agcctctccc actatagtga gaaaggctta
     9001 ataaattatc ttctaacgta cgaatacata cataaccttt ctcacgctct tgatgccacc
     9061 accacgacgc gaataatatg caggactgcc aggttaatag atgtatgtaa attcataact
     9121 taattcttct tttttgtttc aaacgtgctg caaaggtaag ggctttttta taatctccaa
     9181 acaaattgaa gaaaaaaata agataaatat gaataatcgt aagaaaatat cgccctaaaa
     9241 tcctatttta tcacttaaca gttctaaata gaaccattca gacagccaat gtaaatgtat
     9301 tgccaatcat tgaaaccatt taataatctg aaaattacca aaggctctct acatcccgaa
     9361 acaaataatt cgtatctttg tctcttcaaa tactcaaaaa aaagtattta ctaattaaat
     9421 aaagatagaa aattaatgga aacagtagaa aacaagtaca tcaccgtagc atataagctg
     9481 tactcaatcg aaaacggaga aaaagatttc gaagaagaag cacccgtaga gcatcctttt
     9541 cagtttatct caggtctggg aatgacactc gaaccctttg aagcccagat aaaagacttg
     9601 cagataggcg ataaattcga ctttaccatt ccggcatcag aagcttatgg tgaatatgac
     9661 gacgaccatg ttattgacct ccccaaagaa atcttcatga tagaaggaga attcgacagc
     9721 gatcgtgtag tagaaggtgc cgttatcccc ttgatgactt ctgaaggtca acgcatcaac
     9781 ggaagtgtgg tagaagtgaa ggaagatatc gtcgtaatgg atatgaacca tccgctcgca
     9841 ggttgtgact tgaacttcac tggagaagta gtggaaagcc gcctggctac aaacgaagaa
     9901 cttgccgaag tcgcccgtat gatgggtggc ggttgcggca gctgcggttg tggtgactgt
     9961 ggcgacggat gcggcgacca tgaatgtgga ggcggatgct gccactagaa gaattaaaaa
    10021 tgaagaatta aaaatgaaag aatcaaacta cgcaatataa gtatgctgca tgataattct
    10081 ttcattttta attcttcatt tttttaatta tttacttgtc attatctcca ataccaattt
    10141 atccgtttca ttcattcctt tagaaccgat ttttgtcaga ttacggatac tctgatccac
    10201 atcctcatca ataatacctt ctacggaagt tacacaacgg ttttccatgg ccatgatggc
    10261 tgaaagtact gcggttgaaa ctccggtagt cactttcaat gcacaactag gtttggcacc
    10321 atcacaaatc attccggtaa gattggcaat catgttctgt acagcatatg ccacctgctc
    10381 ataagtaccc cccattagcc aagttatacc gcaactggaa ccagtggcag caaccacaca
    10441 accgcataag gcggataacc gtcccaaact ctgcttgata tagattactg tcaaatggct
    10501 caacatcaag gcacgaatca attcttcttc tgatttcccg ttttcttcgg cataaatcaa
    10561 aaccggcaac gtagcggata taccttgatt accgcttcct gaattactca tgaccggaat
    10621 catggctcct gccatacggg catcgcaagc accggaagta taagaaagaa tatgggaaaa
    10681 aacactgtcc cccataacct tatgctcgta agtaccacga aggatttttc ccaagccatg
    10741 tccgtaatca ccctcaaaag agctttctgc ggcagcctta ttcagacggg ccgtttcgag
    10801 gataaaacga atttcgtcca acggagccgt caaagcaaaa tcatagactt tccgcaagct
    10861 taaatccagc gcaccttcct ccttttctgt gcttgcaaca gcctgcttgt tcaacagcac
    10921 ttccccattg cgtgccatgt atacaaagga agtgtgtcca cctgcaatga tagcagtgga
    10981 cttttcatcc ccgacctcac aacaaacttc aacataaagc ttctctttaa tgccatcttt
    11041 cagtgctata tggatgcgct tttcatctat aaaacgtctt ccttcttcca cggcatcggg
    11101 attacaatcc ttcaatacct ccagttgata ttccgattta ccgattaagg caccaagcgc
    11161 tactgcaata ggcagcccaa tcattcctgt accgggaatt cctacgccca tcgcgttctt
    11221 caagatattg gcacttaaaa gaaccgttat cttttccgga tgtctgccca atacttccgc
    11281 agcttttgcc acacacaatg ccacagctat aggttctgtg caacctatag caggaacgac
    11341 ctcggattta accaaatcaa taatctgttg tctttccgtt tttgtcatat ttattcaatt
    11401 tagatgcaga caaaggtaat gtattttatt ctataataga aggaatagaa ggaataaaat
    11461 aaatcccact attaagacat tgcttaatag tgggattccc tatcttaagt tgttatcttc
    11521 ctgtctaaat tagattactt tttcaaattc aaacccaatt caaactttgt agtttttgac
    11581 attgcagtcg gaaggtctcc caatatagct tttatcatag gaccaaaact acctaatgca
    11641 tccggatcat caggaatcaa ttctgcaatt gccggtccca tagcagcaat agtagtcata
    11701 agttctttat caataaagat tttcacttct tcattattat tagacaacgc ataattcaca
    11761 gggattccat tcttcacaag ttccaacaat tgagatataa cagtagttat atcagcttta
    11821 gtattagcat cggctattat tttttccaga ttcaggaaaa gcaacatttt accattcccc
    11881 tgcaatttaa aggttgcata atctgccggt gaagtctccc ataccggagt tattggcttc
    11941 tcacctgaaa gatctatccc tgcagaagaa taagtggcca ctatattacc gtcagcactc
    12001 aaagtaacat cctgcaatac ctgcggcaat atcacagacc ccatctgtat agc
//
