LOCUS       gnlProkkaHBKFIHJB_22   10635 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|HBKFIHJB_22.
ACCESSION   gnlProkkaHBKFIHJB_22
VERSION     gnlProkkaHBKFIHJB_22
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-18 01:34:24
            Original ID  :: gnl|Prokka|HBKFIHJB_22
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 10635
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10635
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[1321:5635]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      1322..5635
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..10635
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10635
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             3..95
                     /locus_tag="ctg22_1"
                     /transl_table=11
                     /translation="MGNIANILGYATSFSSLGMMIASIANLIKK"
     CDS             110..1258
                     /locus_tag="ctg22_2"
                     /transl_table=11
                     /translation="MSEQRQDKNLLSEPHKTESDEIEIDLVDIFRKIIAIRKKLYKAVG
                     IGFIIGIIVAVSIPKQYTVKVTLSPEMGNAKGSNGLAGLAASFLGDGALIGESTDALNA
                     SLSADIVSSTPFLLELLEMEVSVSKKDDKMTLGSYLDEESSPWWDYLIGFPGIVIGGVK
                     SLFGEDTVPASGGRQGTIELTKEVNEKINFLKKKISASIDKKTAITSITVTLQNPQITA
                     VIADSVVHKLQEYIIGYRTSKVKEDCAYLERLFKERQQEYYAAQRKYADYVDAHDNVVL
                     QSVRAEQERLQNDMSLAYQIYSQVANQLQVSRAKVQEEKPVFAVVEPAVVPLKPSGMGL
                     KIYILLFVFLSVSGTLVWVFFGKSLLASLRKELKNKEIEQDK"
     CDS             1322..2041
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064:glucose-1-phosphate
                     adenylyl/thymidylyltransferase (Score: 56.8; E-value:
                     3.1e-17)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg22_3"
                     /sec_met_domain="NTP_transf_3 (E-value: 2e-16, bitscore:
                     52.9, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRTAMIMAAGMGTRFGQYTELIPKGFVKVGGIPMIVRSIDTLLS
                     CGIERIVIGTGYKQEVYEELKTDYPMLETCFSPRYAETNSMYTLYNTREILGNDDFLLL
                     ESDLIFEKQAIMSLLECPAADAMLIAPVTKFQDQYYVEHDDNFRLSSCSVNKNKLNAKG
                     ELVGIHKLSGSFYKIMCADYASIVDEQPNLGYEYELLRISCSQSPVYVHKVEGLKWYEI
                     DDISDLEYAEKYIVPYC"
     CDS             2062..3363
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 208.9;
                     E-value: 1.5e-63)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg22_4"
                     /sec_met_domain="CTP_transf_like (E-value: 1.1e-12,
                     bitscore: 40.6, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates (E-value: 1.1e-120, bitscore:
                     394.2, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 1.3e-62, bitscore:
                     203.6, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKTVYIGMTADIMHPGLIRIINEATKYGDVIIGLLTDKAIAEHK
                     RLPYLTYEQRKEVVQNIKGVCKVVPQEEWSYVENLKRIKPDYIIHGDDWKTGPLREERV
                     RVFEVMNEQGGKVIEIPYTLGINSSSLDKDIKAIGTTPDVRLKSLRRLINAKPVVRILE
                     AHDGLCGLIIENQEILKGDKREVFDGMWSSSLTDSTSKGKPDIEAVDLTTRLQDLNNIL
                     ECTTKPIIFDGDTGGKIEHFVFTVRTLERHGISAIIIEDKVGLKKNSLFGTDVIQTQDT
                     IEGFCNKIKAGKASQITDDFMIIARIESLIAGKPVSDALERAFAYVQAGADGIMIHSKN
                     KSGEDIKEFCLAFRKQYAHVPIVVVPTTYDHIYESELCDWGVNIIIYANHMLRAAYPAM
                     MNVAKIILENERALEVRELCMPIKEILELIPGTK"
     CDS             3380..4504
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 58.1;
                     E-value: 1.1e-17)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg22_5"
                     /sec_met_domain="TPP_enzyme_N (E-value: 6e-20, bitscore:
                     63.7, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 5.2e-20, bitscore:
                     64.0, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLSVEKVYETFLSHDVDFFTGVPDSLLKNICAYITDHTSREKHII
                     AANEGAAVGIASGYYMASGKVPVVYMQNSGLGNTVNPLLSLADEQVYSFPMLLMIGWRG
                     EPGTKDEPQHKKQGEVTLDLLKAMRIPYIILDSNENDAFIQLHDIIQSAKTKNIPHAII
                     IRKDVFGKYKLQKEFGCNYPLSREDALQIVVDYLPENSVVVSTTGKLSRELFEYREMKE
                     QGHEHDFLTVGSMGHSSSISLGIAIAKQDRPVYCLDGDGAFIMHLGAISNIGDLSPKNY
                     YHILFNNGAHESVGGQPTLGFSLDIPAIVRGSGYKHTYTVCTKVEIEEAMKQLPKLCGP
                     VLLEIKVKIDSRENLGRPTTTPIENKEHFMDFLK"
     CDS             4514..5635
                     /NRPS_PKS="Domain: Aminotran_5 (30-366). E-value: 2.9e-34.
                     Score: 110.4. Matches aSDomain:
                     nrpspksdomains_ctg22_6_Aminotran_5.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139:aminotransferase class V (Score: 76.3; E-value:
                     3.6e-23)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg22_6"
                     /sec_met_domain="Aminotran_5 (E-value: 8.6e-31, bitscore:
                     99.3, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIERKILLNPGPATTTDSVKMAQVVPDICPREKEFAGMMKQLRD
                     DLVRVAHGNLEKHTAVLFCGSGTINIDICLNSLLPEDKRVLIVNNGAYSTRAVEVCQYY
                     GLPHINLEFSVYERPDLSVVENVLQENPDIAMVYTTHHETGTGILNPIREMGAIAHKYQ
                     AKFVVDTTSSLGMIPFDIEKDNVDFCMASAQKGLQAMTGLSFIIGNEEQIKFSKKYPKR
                     SYYCNLYLQYENFERTGEMHFTPPVQTIYATRQALNEYFEVGEEAKFARHKRVFEAIHS
                     GINEIGLKSVIKREWQSGLVVSVQYPEDPNWDFEKIHDYCYERGFTIYPGKISTEDTFR
                     ICALGEIEVDDIENFFKVLKAALNHYNVTLPMS"
     aSDomain        4604..5611
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg22_6_Aminotran_5.1"
                     /evalue="2.90E-34"
                     /label="ctg22_6_Aminotran_5.1"
                     /locus_tag="ctg22_6"
                     /protein_end="366"
                     /protein_start="30"
                     /score="110.4"
                     /tool="antismash"
                     /translation="PREKEFAGMMKQLRDDLVRVAHGNLEKHTAVLFCGSGTINIDICL
                     NSLLPEDKRVLIVNNGAYSTRAVEVCQYYGLPHINLEFSVYERPDLSVVENVLQENPDI
                     AMVYTTHHETGTGILNPIREMGAIAHKYQAKFVVDTTSSLGMIPFDIEKDNVDFCMASA
                     QKGLQAMTGLSFIIGNEEQIKFSKKYPKRSYYCNLYLQYENFERTGEMHFTPPVQTIYA
                     TRQALNEYFEVGEEAKFARHKRVFEAIHSGINEIGLKSVIKREWQSGLVVSVQYPEDPN
                     WDFEKIHDYCYERGFTIYPGKISTEDTFRICALGEIEVDDIENFFKVLKAALNHY"
     CDS             5632..5775
                     /locus_tag="ctg22_7"
                     /transl_table=11
                     /translation="MIAEILLKIRHFYFSLRGIHFHPESVISGVPIRSFRLVGKYGNIN
                     LR"
     CDS             5978..7462
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg22_8"
                     /sec_met_domain="Polysacc_synt (E-value: 7.6e-31, bitscore:
                     99.7, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MENLKQKTVSGIMWSAIERFSLQGVQFIIQIILARLLLPSDYGMI
                     GMLAIFLQVAQVFIDSGFTNALIQKKDRTEEDFATVFYFNILVAVLFYGILFFSASLIA
                     DFYNMPTLVLVIRFIALSLIINALSAIHRTKLIISVNFKTQSKISLGAAFISGVIGIWM
                     AYVGCGVWALVWQTLLNSIILTILFYCLVHWKPLHTFSKSSFERLFNFGSKLLISSLIN
                     TVYRNLYTIVIGKKFSVVELGYYTRAEQFAIFPSNNLNALVSRVAYPILSSIQDDDKCL
                     TNAYRNYIRLSSYIIFPLMVGLLVLANPIISLLLTDKWSGVVILLQILCLDWMFDHLSQ
                     INLNLLWVKGRSDLSLRLEIIKKTIAIFILFVSIPFGLEVMCWGRVIYSLIATYLNTYY
                     TNSLIDLTLKLQVKDVFPSLILSFIMGGIVFICISFFETDIVKIVIGCITGMSFYILLS
                     FLFKLDSFFCILTLIIKTKNIDENIKKDFSSNSKDN"
     CDS             7416..8675
                     /locus_tag="ctg22_9"
                     /transl_table=11
                     /translation="MKILKKIFQVIVKIINHCVPVDSRSLYFIPHPNCRTDKYDIINYS
                     SDNVLVLLNYLLKKDSAEYYKIYVEIYDSSRISEYQEYIYGINPNIRCTFLCACVGRFF
                     FNKVSFKDMLYAFFCFCRASKCFTATFYYDFSFKKRSQQIICLGYYTPFKDDYHMGDHS
                     YDKFRNTTCNSFDYSIATSCLSARIISIDCGISYDKFKVLGFPRNDLLISKNNCNVIKR
                     EISKFAGYDVTKYIVYTPTFRDYETVTEGNLRSILGYVDCDLLKLSKILLKFNAALILK
                     LHPLQNKTVLKKDLPKGILVFEQTYKYGLYDLLSFSDGMITDYTSTYFDFLLVNKPVIF
                     NFYDIEEYRRVRGFSFEPIEFFCAGDIVYNYNELIDAVMGLLAGKDIHAEHRRHISLLM
                     NQFQDDNSTKRICDIFLNEI"
     CDS             8684..9430
                     /locus_tag="ctg22_10"
                     /transl_table=11
                     /translation="MNYAFVVQARLGSTRLPGKILKPFYGNQSILDLMVHKLSAISNIP
                     VIIATTNSVINEPIEKKALALGVKCFRGEENDVLKRFIDVAEYFDIQGIFRICSDNPFL
                     DVHAARQLVEIAMKSCNDYISFDIDGTPSIKTHFGFWGEFVTLDALKRVIGFTDDLLYR
                     EHVTNYIYSHPELFNIQWISGSPVVSKHHNIRLTIDTLEDFSVAQRIYRDLQEKRVEIS
                     IEVIVDYVRRHAEYIQLMKQQIKKKF"
     CDS             9434..10474
                     /locus_tag="ctg22_11"
                     /transl_table=11
                     /translation="MKNTYIIGEIGQNHNGSVDLAKLIIELISRPVHEDVFGMDFMPMN
                     AVKMTKRDLSEELAVSQMNQIYDNPNSFGRTYGEHRAFLELDDQAHFEIYKYAKSLGLD
                     FIETLCAKGCLSLLKLFTPDRLKVASRDLTNLPLLEALAETHIPIILSTGMAGQRELDN
                     ALDVITRYHSNIAILHCVSQYPTHPNNLNLRTITYLKKHYNKFEIGFSDHTIGISAATA
                     AVAMGAEIIEKHVTIDRHMKGTDQLGSLGPDGVNRMIRDIRIAECWLGTEDLYIEKGVE
                     KSKIKLERSIATRKYIPAGSIIQESDIHLLSPGDGYKWIDKKNVIGHFAKQDISANEII
                     YPDFIE"
ORIGIN
        1 agaaagggaa catagctaat attttaggtt atgctacttc cttcagttct ttgggaatga
       61 tgattgcttc tattgctaat cttataaaga aataatagaa tttactttta tgtcagaaca
      121 acgacaggat aaaaacttgc tctctgaacc acacaagaca gaaagtgatg agatagaaat
      181 tgatttggtc gatatctttc gcaagattat tgctattcgt aaaaaattat acaaagccgt
      241 tggaattggt tttattattg gaataattgt agcggtaagt atccctaaac agtatacagt
      301 aaaggttacc ctttctcctg aaatgggtaa tgcgaagggg agtaatggtt tagccggact
      361 tgctgcctcg tttttaggag atggggctct aataggggaa agcacagatg ccttgaacgc
      421 ttctctttca gcagatattg tttcttcaac tcctttttta ttggaacttt tagaaatgga
      481 agtctccgtt tctaaaaagg atgataaaat gactttgggg tcttatctcg atgaagagtc
      541 atctccttgg tgggattatc ttataggttt tccgggcata gtaataggag gagttaaatc
      601 attattcgga gaagatacgg ttcctgccag tggagggcgg caaggaacta tcgaattgac
      661 gaaagaagta aatgagaaga ttaattttct taaaaagaag attagtgcat ccattgataa
      721 gaaaaccgcc ataacgagca ttacggtcac cttacaaaat ccgcagatca ctgcggttat
      781 agcagattct gtcgttcata aattacagga atatattatt gggtatcgaa cttcaaaagt
      841 aaaagaagac tgtgcgtatt tggaacggtt gtttaaagaa cgtcagcagg aatattatgc
      901 tgctcaaaga aaatatgcgg attatgtaga cgcccatgat aatgtggttc ttcaaagtgt
      961 acgtgctgag caggagcgtt tacagaacga catgagtttg gcttatcaga tatatagtca
     1021 ggttgctaat cagttgcagg tatccagagc caaagtacag gaggaaaagc cagtctttgc
     1081 agtagttgag cctgccgttg tacctttgaa accttcaggt atgggactca aaatttatat
     1141 tttattattt gtgttcctgt ccgtatctgg tactctcgtg tgggtgtttt ttggcaaaag
     1201 tctgctggct agcttgagaa aagaactgaa aaataaggag atagaacagg ataaatgatg
     1261 ctaaaacgtc gtttacaaca ttcttacatc aattaaattc acttactata ttattaaacg
     1321 aatgatacgt acagctatga taatggctgc gggcatggga acccgttttg gccaatatac
     1381 agaattgata cctaaagggt tcgtcaaagt gggaggtatt ccaatgatag ttcgttctat
     1441 tgatactttg ttatcatgtg gcattgagcg aattgtaatc ggtacaggat ataaacaaga
     1501 agtttatgaa gaattgaaga cagactatcc tatgcttgaa acctgtttta gtcctcgtta
     1561 tgctgaaaca aatagtatgt atactttata taatacgcgg gagattctgg gcaatgatga
     1621 ttttttattg ttagagtcag atttgatttt tgagaaacaa gcaataatga gcttattgga
     1681 gtgtcctgcg gcagatgcaa tgctaatagc tccagtgaca aagtttcaag atcagtatta
     1741 tgtggaacat gatgataatt ttcgcctttc ttcatgttct gtcaataaga ataaactaaa
     1801 cgctaaaggc gaattggtcg gcatccataa actatccggt tccttttaca aaataatgtg
     1861 tgctgattat gcgagtattg ttgatgaaca acccaatttg ggatatgagt atgaattact
     1921 acgaatatct tgttctcaat ctcctgttta tgtgcataaa gtagaagggc tgaaatggta
     1981 tgaaatcgat gacatatcag atttggaata tgcagagaaa tatattgttc cgtattgtta
     2041 attaaaataa tatatcaaat tatgagtaag acagtttata ttgggatgac tgcggatatt
     2101 atgcatccag gacttatccg cattattaat gaggctacta aatacggtga tgttataatt
     2161 ggtcttctta cagataaagc tattgcggag cataaacgcc ttccttatct gacctatgaa
     2221 caacgaaaag aggtagttca gaatattaaa ggcgtatgta aagttgttcc tcaagaagaa
     2281 tggagctatg ttgagaatct caaacgcatt aaacctgact atataattca tggtgacgac
     2341 tggaaaaccg ggcctttacg tgaagaacgt gtgcgcgtat ttgaagtgat gaatgaacag
     2401 ggaggaaagg ttatcgaaat tccatatact ttgggaatta attcatcttc tttggataaa
     2461 gatattaagg ctataggtac aacccctgat gtacgtttaa aatcacttcg tcgtttgata
     2521 aatgccaaac ccgtagttcg tattttggaa gctcatgatg gactatgtgg cttgataatt
     2581 gaaaatcagg aaatattaaa aggggataag agggaagtat ttgacggaat gtggtctagt
     2641 agccttacgg attcaaccag taaaggtaaa cctgatattg aggcggttga tttaactacc
     2701 cgattgcaag atttgaataa tattctggag tgtactacta aacctattat ttttgatgga
     2761 gatacaggtg gtaaaattga acatttcgta tttacagtac gcactttaga acgtcatgga
     2821 atttcagcta taataattga agataaagtt ggattaaaaa agaattcatt gtttggtaca
     2881 gatgttattc aaactcaaga tacaatcgaa ggtttctgta ataagatcaa agcaggaaag
     2941 gcatctcaga ttactgatga ttttatgatt atcgctcgta ttgagagcct tatagcggga
     3001 aagccggtaa gtgatgcttt agagagagct tttgcatatg tccaagcggg agcggacggt
     3061 attatgatac atagcaaaaa taagtcgggt gaagatataa aagaattttg tttggcgttt
     3121 cgaaaacagt atgctcatgt acctatcgtg gttgtgccta ctacatatga tcatatttat
     3181 gagtctgaat tgtgtgattg gggtgtgaat ataattattt atgctaatca tatgcttcgt
     3241 gccgcttatc ctgctatgat gaatgtcgca aagataatat tagagaatga acgtgcttta
     3301 gaggtgcgcg aactgtgtat gcccataaaa gaaatattgg aactgattcc aggtactaaa
     3361 taaaaagagg aatatcatta tgttaagcgt agaaaaagtt tatgaaacgt ttctgagtca
     3421 tgacgttgat ttttttacag gagttccaga ctcattacta aaaaatattt gtgcctatat
     3481 cacagaccat acttcacgtg agaaacatat catagctgct aatgaaggtg cggctgtagg
     3541 aattgcttca ggttattata tggcatcagg taaggttcct gtggtttata tgcaaaattc
     3601 cggcttgggt aatactgtta atcctctgct gtctcttgca gatgaacaag tatacagttt
     3661 tccaatgctt ttgatgattg gctggcgtgg tgaaccggga acaaaagatg aacctcagca
     3721 taaaaaacag ggtgaggtaa ctttagattt gttgaaagca atgcggattc cttatataat
     3781 tcttgattca aatgagaatg atgcatttat tcagctccat gatatcatac aatcagcaaa
     3841 aactaagaat attcctcatg caataattat tcggaaagat gtttttggca aatataaact
     3901 tcaaaaagag ttcggatgta attatccttt atctcgtgag gatgctttgc aaatagttgt
     3961 ggattatctg cctgaaaatt cagtggtcgt ttctactact ggcaagcttt ctcgtgagtt
     4021 atttgaatat cgagaaatga aagagcaagg tcatgaacat gattttctca cggtaggctc
     4081 tatgggacat agttcatcaa tctctttggg tattgctata gcaaagcaag atagacctgt
     4141 ttattgcttg gatggtgatg gagcatttat tatgcattta ggggcaatta gtaacattgg
     4201 cgatttatct cctaaaaact attatcatat tttgtttaac aatggtgctc acgagtctgt
     4261 aggaggacag cctactttag gatttagttt agatattccg gctattgtcc gggggagcgg
     4321 atataagcat acttatactg tttgtacaaa agttgaaatt gaagaagcaa tgaagcagct
     4381 tccaaagtta tgtggtcctg ttttgttgga aataaaggtt aaaatagatt ctcgggagaa
     4441 tttgggacgt cccacgacta ctcctataga gaataaggag cattttatgg attttttaaa
     4501 ataaatatat tcgatgaaaa tagaaagaaa aatattatta aatcctgggc ctgccactac
     4561 tactgacagt gtaaaaatgg cacaagttgt tccggatatt tgtcctcgcg agaaagaatt
     4621 cgcaggtatg atgaaacaac ttcgggacga tttggtcaga gttgctcatg ggaatttgga
     4681 aaaacatacc gctgtattat tttgtggctc aggaaccatc aatattgata tatgtctaaa
     4741 ttctcttctt cctgaagaca aaagggtgct tatagtgaat aatggggcat atagtacccg
     4801 tgctgtagaa gtgtgtcaat attatggttt gcctcatatt aatttggaat tttccgttta
     4861 cgaacgtcct gatttatcgg tggtggaaaa tgtgttgcaa gaaaatcctg atatagctat
     4921 ggtttatact actcatcacg agacgggtac aggaattctg aaccctattc gcgagatggg
     4981 cgctatagct cataaatatc aggctaaatt tgtcgtcgat actacttctt ctttgggcat
     5041 gattcctttt gatatagaga aagataatgt ggatttttgt atggcatctg ctcaaaaagg
     5101 acttcaagcg atgacaggtc tttcttttat tataggcaat gaggaacaga ttaagttttc
     5161 aaaaaaatat cccaagcgtt cttactattg taatctttat ttgcagtatg agaattttga
     5221 gagaacaggt gaaatgcatt ttactccacc ggtacaaact atttacgcca ctcgtcaggc
     5281 attaaatgaa tattttgaag tgggtgaaga agctaagttt gcccgtcaca aaagagtttt
     5341 tgaggctatt cattcaggta taaatgaaat tggtcttaaa agtgtaataa agcgtgaatg
     5401 gcagtcagga ctggttgtct cagttcaata cccagaagat cccaactggg attttgagaa
     5461 aatacatgat tattgttatg agcgtggatt tacgatttat ccaggtaaga tatcaactga
     5521 ggatactttt agaatctgtg ctttaggaga gatagaagta gatgatattg agaacttctt
     5581 taaagtacta aaagctgcat taaatcatta taacgtcaca ttaccgatgt catgattgca
     5641 gaaatattat tgaagattcg tcatttttat ttttcccttc gtggtataca cttccatccg
     5701 gaaagtgtta tttctggagt gcctattcgt agctttcgct tagtaggcaa atatggcaat
     5761 attaatttga ggtgatgcat taggagttct ttattcttat aaaaaggcat cggtagttat
     5821 aggagataat gtttgtgtag ggtaatttgc ttttagtggg agagaccata ttagaattgc
     5881 ggtaaggggc gaagaagata ataaccaatt agtgagaata ttggaaaaat ataattgata
     5941 tcggtaaatg tagttgtttt tatactgtat ttaagtaatg gaaaatctaa agcagaaaac
     6001 tgtatcagga ataatgtgga gcgctataga acgtttctct ttacaaggag tacagtttat
     6061 aattcaaata atattagctc gtttgttact accatcggat tatggtatga tcgggatgtt
     6121 agctattttt cttcaagtcg ctcaagtatt tatagatagc ggttttacaa atgctttaat
     6181 ccagaaaaaa gatagaactg aagaggattt tgccactgtc ttttatttta atattcttgt
     6241 cgcagtatta ttctatggta tattgttttt ttcggcttct ttgattgcag acttttataa
     6301 tatgccgact ttagttcttg taattcgttt tatagcattg tcgttgataa taaatgcttt
     6361 atcggctatt cacagaacga aattaattat ttctgtaaac tttaaaactc aatctaaaat
     6421 ttcattaggt gcagctttta tatcaggcgt gattggaata tggatggctt atgtcggttg
     6481 cggggtttgg gctttagttt ggcaaactct cttaaatagt ataattttga caattttgtt
     6541 ttactgttta gttcattgga aacctttaca tactttctcc aaaagttctt ttgaaagatt
     6601 attcaatttc ggatctaaat tattgatctc aagtcttatc aatacagtat atcgtaatct
     6661 gtataccatt gtaataggaa aaaagttttc tgttgtagag cttggttact atacaagagc
     6721 agaacaattt gctatttttc cttccaataa tttaaatgct ttagtttcta gagtagcgta
     6781 tcctatttta agttccattc aagatgatga taaatgttta acaaacgcat atcgaaatta
     6841 tatcagatta tcctcatata taatttttcc tttaatggta ggtttacttg ttttggctaa
     6901 tcctattatt agtctattgt taacagataa atggtctggg gttgttattc ttttacagat
     6961 attatgtttg gattggatgt ttgatcattt gagccaaatt aatttgaatt tattatgggt
     7021 taaaggaaga tctgatctgt cgttacgtct tgaaataata aaaaagacga ttgctatatt
     7081 cattcttttt gtgtcaattc catttgggct tgaggtgatg tgttggggta gagttattta
     7141 ctctctgata gcgacatatt tgaatacata ttatactaat tctcttattg atttgacctt
     7201 aaagttgcaa gttaaagatg tatttccaag tttaatactc tctttcataa tgggggggat
     7261 cgtttttata tgtatttctt tctttgaaac tgatatagta aaaattgtga ttggatgtat
     7321 tactgggatg tccttctata ttttactttc ttttcttttt aagctagatt cttttttttg
     7381 tattttaaca ttgatcatta aaactaaaaa catagatgaa aatattaaaa aagatttttc
     7441 aagtaatagt aaagataatt aaccattgtg tgccagttga tagtagatca ttgtatttta
     7501 ttcctcatcc taattgtaga acagataaat atgatattat aaattattcg tcagataatg
     7561 ttctcgttct gttaaattat ttgctaaaaa aagatagtgc tgaatattat aaaatatatg
     7621 ttgaaattta tgattcttct cgtatttcag aatatcaaga atatatttat ggcataaatc
     7681 ctaatattag gtgtactttt ttatgtgcat gtgttggacg ttttttcttt aataaagtat
     7741 cttttaagga tatgttgtat gccttttttt gtttttgtag agcaagtaaa tgttttacag
     7801 ctacttttta ttatgatttt tcatttaaaa aacgctctca acagattatt tgtttggggt
     7861 attatactcc attcaaagat gattatcata tgggagatca ttcttatgat aaatttcgta
     7921 atacaacatg taactcattt gattactcta ttgctacttc ttgtttaagt gctagaataa
     7981 tttcaataga ttgtggaatc tcatatgata aattcaaagt cttaggattt cccagaaatg
     8041 atttgttgat atcgaaaaat aattgcaatg ttattaaaag agaaatttcg aaatttgcgg
     8101 gatatgatgt aactaaatat atagtttata ctccaacttt tcgtgattat gagactgtta
     8161 ctgaaggtaa tttgcgttca atactcggat atgttgattg tgatttgttg aagttatcga
     8221 aaatactatt gaagtttaat gcggctttaa ttcttaaatt acatcctttg cagaataaaa
     8281 cagtcttaaa aaaagattta cccaaaggta tacttgtttt tgaacaaaca tataaatatg
     8341 gattgtatga tcttttgtca ttttcagatg gaatgattac tgattatact tctacctatt
     8401 ttgatttttt attggtaaat aagccagtca tatttaattt ctacgatatt gaagaatatc
     8461 gtagagtaag aggtttctca tttgagccaa tagaattttt ttgtgcaggt gatattgttt
     8521 acaattataa tgaattgata gatgctgtga tgggacttct ggctgggaaa gatattcatg
     8581 ctgaacatcg acgtcatatt tctttattga tgaatcaatt tcaagatgat aattcaacaa
     8641 agagaatatg tgacatattt ttaaatgaaa tataataaat aaaatgaatt atgcatttgt
     8701 ggtgcaggca cgtttaggtt ctacacgttt gcctggaaaa atattgaaac ctttctatgg
     8761 taatcaatcg attcttgact taatggttca taagctttct gctatatcga atattccagt
     8821 aattattgct acaacaaatt ctgttatcaa tgaacctatt gaaaagaagg cacttgcatt
     8881 aggggtaaag tgcttcagag gtgaggagaa tgatgtttta aaacgattca ttgatgttgc
     8941 tgaatatttt gatatacagg gtatattccg aatatgttct gataatccat ttttagatgt
     9001 acatgcggca aggcaattgg tcgaaatagc aatgaaatct tgtaacgatt atataagttt
     9061 tgatattgat ggtactccat caattaaaac tcatttcggt ttttggggag aatttgtaac
     9121 gcttgatgcg ctgaagcgag ttataggatt tactgatgat ttattgtatc gtgaacatgt
     9181 tactaattat atatatagtc atcctgaact ttttaatatt caatggattt caggatctcc
     9241 agtcgtgtca aaacatcata atattcgact cacgattgat acgttagaag atttttctgt
     9301 agcacagaga atatataggg atttacaaga aaaaagagtg gaaatatcga tagaagtgat
     9361 tgtagactat gttcgaagac atgcagaata cattcaactg atgaaacaac aaataaaaaa
     9421 aaaattctaa ataatgaaga atacttatat tattggtgaa atagggcaga atcataatgg
     9481 ttctgttgac ttggctaagt tgattattga attaatctca cgacctgtac atgaggatgt
     9541 ttttggtatg gatttcatgc caatgaatgc tgttaaaatg actaaaagag atttatcaga
     9601 agaattggct gtttctcaaa tgaatcaaat atatgacaat cctaattctt ttgggcgtac
     9661 ttatggtgaa catcgtgctt ttcttgagct tgatgatcaa gcgcattttg agatttataa
     9721 atatgctaag tcattaggat tagattttat cgagacgtta tgtgccaaag gatgtctgtc
     9781 tttgcttaaa ctgttcacac cggataggct aaaagttgct agtcgtgatt tgactaactt
     9841 accattgctt gaagcattag cagaaactca tattcctatt atattatcga caggaatggc
     9901 tggtcaaaga gaacttgaca atgcattaga tgtgataacg agatatcata gtaatatagc
     9961 tattctacat tgtgtatctc agtatccaac tcatccaaat aatttgaatc tacgtacaat
    10021 aacatatttg aagaagcatt acaataagtt tgagataggt ttttctgatc atacaatagg
    10081 tatttctgct gctacagctg ctgtagcgat gggagcggaa attatagaaa agcatgtaac
    10141 aattgatcgg catatgaaag gaacagacca gcttggctct ttaggtccag atggggttaa
    10201 tcgtatgatt cgagatattc gcatagcaga gtgttggctt ggtactgaag atctttatat
    10261 agaaaaaggg gtggagaagt ctaagataaa acttgaacgt tctattgcca ctcgaaaata
    10321 tattccagca ggtagtatta ttcaagagtc ggacattcat ttactgagtc ctggtgatgg
    10381 ttataaatgg atagataaaa aaaatgtaat tggtcatttt gctaaacaag atatatcagc
    10441 gaatgaaata atatatcctg attttattga atagatatat tcctactgca acttgtatta
    10501 cggtatagag tactgcctgc tataagctaa gtagtgatta ataaataagg gtaaaatact
    10561 aaaaaaatga aagagataaa gcttatactt acagatattg atggcgtttg gactgatggc
    10621 ggaatgtttt atgat
//
