LOCUS       c00100_gnlPro..        14774 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|GMLGELOK_100.
ACCESSION   c00100_gnlPro..
VERSION     c00100_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-07 10:01:09
            Original ID  :: gnl|Prokka|GMLGELOK_100
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14774
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..180
                     /locus_tag="ctg100_1"
                     /transl_table=11
                     /translation="VYSKMNKSVKDMRKKSVNTLLVFGVVVAIILLMIWLFLGTTLVED
                     TSTEITPVPIEQTN"
     protocluster    1..14774
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[246:4774]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      247..4774
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..14774
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14774
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             complement(247..1407)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg100_2"
                     /sec_met_domain="OAD_beta (E-value: 1.4e-153, bitscore:
                     501.2, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQESFLTFLGENLQLFLTYTGVYNATPGHLIMILVGLLFIFLAIK
                     YEFEPMLLIPIGFGILIGNIPFKDAGLQVGIYEQGSVLNILYQGVTSGWYPPLIFLGIG
                     AMTDFSALISNPKLMLIGAAAQFGIFGAYTIALQMGFEPNQAGAIGIIGGADGPTAIFL
                     SSKLAPNLMGAIAVSAYSYMALVPIIQPPFMRLLTTKKERLIRMKPPRAVSSTEKIIFP
                     IVGLLLTCFLVPSGLPLLGMLFFGNLLKESGVTRRLAETARGPLIDTITILLGITVGAS
                     TQATQFLTLNSIKIFGLGALSFVIATCAGVLFVKLFNLILKDGNKINPLIGNAGVSAVP
                     DSARISQVVGLEYDPTNYLLMHAMGPNVAGVIGSAVAAGILLGFLG"
     CDS             complement(1412..1843)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 64.8; E-value:
                     1.6e-20)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg100_3"
                     /sec_met_domain="Biotin_lipoyl (E-value: 4.6e-21, bitscore:
                     64.8, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKSFKYTINGNVYKVHINSVVDDIADVEVNGTPYQVKLEKPAKKQ
                     MVTLKRPAQAPTTASGDPVVTRPAASTTQGAVKTPLPGVILQVKCNVGDTVKRGQTLII
                     LEAMKMENNINADRDGKIIEIKVHKGDSVLEGADLVVIG"
     CDS             complement(1865..2752)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg100_4"
                     /sec_met_domain="OAD_gamma (E-value: 4.2e-13, bitscore:
                     40.1, seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINKKIGVLLLFALLISFGAKAQRATSMRINEVLVINEDNFVDDY
                     GKRHGWIELFNTSAGTVNIAGCYLTDDKNNPMKYPIPKGDVLTQIQPRQHTLFWADGQP
                     GRGTFHVNFVLDPSKENYIALYDADGKTLIDEVTIPAGQMADISYGRVIDGKDEWAQLK
                     KVTPSTNNLTLDSNEKIDNFKQNDSLGIGMTITAMAVVFLGLFLLYIIFKQIGRLSISA
                     SKRNAQKAAGTTSVSVDAGQESGEIFAAIATALYEMSDDNHDIEHTVLTIHKVQRTYSP
                     WSSKLYGLRQTPHK"
     CDS             complement(2774..4327)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Btheta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg100_5"
                     /sec_met_domain="CT_Btheta (E-value: 1.5e-292, bitscore:
                     960.5, seeds: 72, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNQLEKVKELIALREQARLGGGEKRIESQHKKGKYTARERIAML
                     LDEGSFEEFDMFVQHRCTNFGIEKTKYLGDGIVTGYGTIDGRLVYIFAQDFTVFGGALS
                     EALAMKICKVMDQAMKMGAPVIGLNDSGGARIQEGVNALAGYAEIFQRNILASGVVPQI
                     SGIFGPCAGGAVYSPALTDFNIMTRGTSYMFLTGPKVVKTVTGEDVTQEQLGGASVHTT
                     KSGVAHFAVDTEEDGLQLIRKLLSFLPQNNLEETPLVECKDPIDRLDDVLNDIIPDNAN
                     QSYDMYEVIGTIVDNNEFLEVHADYAKNIIVGFARFNGQSVGIVANQPKVMAGCLDSNA
                     SRKAGRFVRFCDAFNIPLVTLVDVPGFLPGTGQEYNGVILHGAKLLYAYGEATVPKITV
                     TLRKSYGGAYCVMSSKHLRGDMNYAWPTAEIAVMGPSGAVEVIFAKEVAAAEDPKACAA
                     EKEAEYKKAFANPYNAAQYGYIDDVIEPRNTRFRIIRALQQLQTKKLSNPAKKHDNLPL
                     "
     CDS             complement(4364..4774)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Glyoxalase_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg100_6"
                     /sec_met_domain="Glyoxalase_4 (E-value: 4e-27, bitscore:
                     85.0, seeds: 51, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MELTHIEHLGIAVKSIEACLPYYEGVLGLKCYNIEVVADQKVKTA
                     FFKVGQTKIELLEPTSEDSTIAKFIEKKGEGIHHIAFAVPDVQAALNEAEEKGVKLIDK
                     APRGGAEGLNIAFLHPKSTCSVLTELCMPGNK"
     CDS             complement(4903..7314)
                     /locus_tag="ctg100_7"
                     /transl_table=11
                     /translation="MKIRAIAALLFILISVSAFGEGRIKITGYVRDADGNPLELVNVRV
                     KNTLIGSMTNEKGYYSFSISPGDSISIIYSCLGYNKAERIIPSAQADMRLNVQMNYTSF
                     DLGEVSVTAIRKQTTTMESLNADKIKLLPDPSGGSIESLVVTFAGVSSNNELSSQYSVR
                     GGSYDENIVYVNGIEVFRPLLIRSGQQEGLSFINPDLTEAVNFAAGGFEARYGDKMSSV
                     LDITYKKPKIFEGSASASLLGANAYVGSSIGKFTQVTGFRFKSGRSILGTMDTDAEYDP
                     KFIDLQTYITYQLAPKWEINFLGNLANNNYKFTPYSRETSFGTAEHPKNFKVYFDGRER
                     DRFQTLFGALTLKHNPNENTELGLQASAFKSKEEEGYDIAGEYWLSENGAENPNDDASA
                     AMSVGRYHEHARNRLNSTVMNVGHYGMARLLNNTLKWGATVQMEKINDKISEWEKRDSS
                     GYSLPQTGNNVSVYSNLFSDNQIESTRFSAYAQDAFKFRTKQGLFTLVAGVRGSYWTYN
                     KEFLFSPRASLGFIPNFDQDLTLRFATGLYYQSPFYKELRRVDKDKNGNNITVLNKDLK
                     SQRSIHFILGGDYTFRAVDRNFKVTAEMYYKKLDNLNPYTVDNVKIRYYGENCAKGYAM
                     GLDVKFFGEFVPGTDSWISFSLMKAQQTIRETTTVPMANSQGYNISLFFQDYFPGYKRV
                     KLNLKGVLSGGLPQTIPGKGYEAGYFRTPAYKRVDIGLSYQLAGGTDAIMDRGFFRHLK
                     NIWLGLDVFNILDIKNVSSYYWITDVYNVQYAVPNYLTGRQLNVRLIVDF"
     CDS             7436..7996
                     /locus_tag="ctg100_8"
                     /transl_table=11
                     /translation="MESFATLIQNRRSTRKFTEQLLSPEQVELILKAALMAPASKRSNP
                     WQFVVVEDKEMLKKLAGCKKNGSAFLEGCALAVVVLANVMESDVWIEDASVASIYMQLQ
                     AEDLGLGSCWCQIRNRVTEDEADSNNYVRSLLDIPYQLDVLSIIGIGYKDQVRKPFDES
                     HLQWEKIHIGKFSLPEENKEAEE"
     CDS             7993..8760
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) F420_oxidored"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg100_9"
                     /sec_met_domain="F420_oxidored (E-value: 1.3e-09, bitscore:
                     28.9, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRVVFVGAGNLATRLSLEMRKSGMSIGQVYSHTSEHAKILADELG
                     CGWTVVPEDIVEDADLYVFSLKDAVLQDVIARVKPNNGLWVHTAGSMPISVFEGLTARY
                     GVVYALQTFSKSREVDFKKIPFFLEANSSEDEKVLGEVARALSSDVRFLSSEKRKNLHL
                     AAVFACNFTNHMYALAEKILEEQQIPGEVLLPLIDETAAKVHVMSPARAQTGPAIRYDE
                     NVINKHMAMLKDPDMRNLYELISRSIHKEARHE"
     CDS             8753..9274
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HAD_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg100_10"
                     /sec_met_domain="HAD_2 (E-value: 6.2e-09, bitscore: 26.4,
                     seeds: 51, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSINYDLRKIKAFVFDVDGVLSCDVIPLHPNGDPMRTVNIKDGY
                     ALQLAVKKGYEVAIITGGYTEAVQIRFSRLGIQHIYMRSAVKVHDFKDFMEKTGLSPEQ
                     IMYAGDDIPDYEVMTRVGLPVAPADAAPEIKEIAKYISSRRGGEGVARDVIEQTMRAQG
                     HWFGEEAFGW"
     CDS             9312..9893
                     /locus_tag="ctg100_11"
                     /transl_table=11
                     /translation="MLENLKKYKIVLASNSPRRRNLLSGLDIDFEVRIIPDIDESYPDS
                     IDSMEIPLYIARSKAEAYKSTMADDELLITADTIVWTFDGVMGKPANREEAYAMLHALS
                     DHVHQVITGVCIMTKDKNVGFSVESAVCFAKLGDEEINYYLDKYKPYDKAGGYGIQEWI
                     GYIGVEAINGSFYNVMGLPVQKLYQELKHF"
     CDS             complement(9896..10273)
                     /locus_tag="ctg100_12"
                     /transl_table=11
                     /translation="MKRYLNQLECKILRAGDSLFNTTTTDNLLIFVFSGKLIIYSQEGT
                     HIAEVAKDHFMLLAQNTNHKVIASAPTRLILIHAGSLSDMIINDPEWNVEKPVVLPIPP
                     ALAHTLNQIEYYMKDKYFTLN"
     CDS             complement(10282..11310)
                     /locus_tag="ctg100_13"
                     /transl_table=11
                     /translation="MRKNITILVSLLILSHTACSDKGQYFEESGSVFHTSYHIKYKAKQ
                     ILTDKIDSELQRFNLSLNPFNPNSTIAKVNNNEDVEVDEWFTEVFNKAEEISQKSGGAF
                     DITCAPLINLWGFGFSKMDSVTPQMIDSIKAFVGYQKVRLEGKKIIKEDPRILLNCSSI
                     AKGYACDVIARLLEKEGVKNYMVEIGGEVTMKGVNQQGDCWRVGINKPEIGTSGVTNDV
                     EEIVQLCQKGGVATSGDYRNFYIKDGKKYAHTINPATGYPAGQNILSATIVAEDCMTAD
                     AYATTFMVLGVEKAKLLAQSIPQIEYFIIYADNNGQQKVTYSKGMLEYLPNRKTLAILE
                     NP"
     CDS             complement(11336..13060)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ILVD_EDD"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg100_14"
                     /sec_met_domain="ILVD_EDD (E-value: 6.3e-184, bitscore:
                     602.5, seeds: 918, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKSQQLRKLAPELDSLRLGSGWKIDELSKPQIIVESSYGHSHPGS
                     AHLDKLVDEAGIGIKEKGGRAANYFVTDICDGEAQGHDGMNYSLVSRDIMAAMMEIHVK
                     ATPFDAGVFIASCDKSVPAHLMAIARLDMPAIFMPGGIMKAGPNLLTLEQIGTYSAQYE
                     RKEITEEQFMVYKRDACPDCGACSFMGTASTMQVMAEALGIALPGSALIPAHLPELKET
                     ARKAGEHALGLAKEELKPSDIMTIQAFENAIMVHAAIAGSSNSLLHLPAIAHELGIQLS
                     PDLFDKIHRKIPYLLNIRPSGFWPGEYFWYAGGVPAIMEEIKEFLHLDVMTVTGKTLEE
                     NLKDLQLNGFYENCHKYLPALGVKVGDIIKPFHTPIKAQGAIAILKGNLAPEGAVVKHS
                     AISPRLMQVTLKARVFDCEENAIEAVLQKKIHPGEAVFIRYEGPKGSGMPEMFYTTEAI
                     ASDPELVETIALITDGRFSGATRGPAIGHVSPEASEGGPIALVENDDLIRIDIPARTLD
                     IIGTDSIERSVEEIEKILSERRAHWIKPESQYKKGILDIYTHNSVSPMKGAYMEFFM"
     CDS             complement(13105..13671)
                     /locus_tag="ctg100_15"
                     /transl_table=11
                     /translation="MLYIEVLLLAIGLSMDSLAVSVTGGAVLKNNCTAGNIIKIASVLG
                     IFQAGMTVIGYTMGLGFEKYICAFDHWIAFTLLLYLGGKMIYDSAKEEEEDGKFDPLCN
                     RTLCGLGIATSIDALAVGISLAILKSPLLLQASTIGVVTFAISAFGVYFGNRFGKRIDL
                     KLDLIGGLILIGIGTKILIEHVFFS"
     CDS             complement(13673..14194)
                     /locus_tag="ctg100_16"
                     /transl_table=11
                     /translation="MSFLELARKRCSIRKYAPKNVEQEKIDYILEAARLAPSAVNYQPW
                     YFVWVQSAEGKAKLQECYPREWFKQAPYYLIVCGDHQQSWKRGDHKDHMDIDTAIATEH
                     ICLAAAEQGLGTCWVCNFDTELCRKHFKIPETIEPVVLIPFGYPSDPALFDETPKKRKP
                     IEEIIKRESF"
ORIGIN
        1 gtttattcta aaatgaataa atcagttaaa gacatgagaa agaaaagtgt gaatacgcta
       61 ttggtatttg gtgtggttgt cgctataatc cttttgatga tctggttgtt cctcgggaca
      121 acgttggtgg aggatacgag tacggagatt actccggttc ctatagagca aactaactga
      181 gaacaataac ataaaaaggc gggatccttt cggacctcgc cttttttaat atagatagtt
      241 gttttattaa ccaaggaatc ctagcaagat accggcagct acagcggaac cgattacacc
      301 tgctacgttc ggacccatag cgtgcatcaa caagtagttg gtcgggtcat attccaaacc
      361 tacaacttgt gagatacgag ctgagtcagg aacggcggat acaccggcgt taccgataag
      421 cggattgatc ttattgccgt ctttcaatat taaattgaat aacttaacga acaatacacc
      481 ggcgcaagta gcgatcacga atgataacgc acctagaccg aagatcttga tagagttcaa
      541 tgtcaagaac tgtgtagctt gggtagaagc acctaccgtg atacccaata agatcgtgat
      601 tgtatcgatc agcggaccac gagcagtctc tgccaaacga cgagtcacgc cactttcttt
      661 caataagttt ccgaagaata gcatacctaa caatggtaaa ccggacggaa ccaagaagca
      721 agtaagcaac aaaccaacga tcgggaagat aattttttcc gtggaagaaa cggctctcgg
      781 cggtttcata cggatcaaac gctctttctt agtcgtaagc aatctcatga acggcggttg
      841 gataatagga accaacgcca tgtatgagta agcggatacc gcgatcgcac ccattaagtt
      901 tggcgctaac ttagaagaca ggaagatagc cgtcggaccg tcagcaccac cgataatacc
      961 gatagcacct gcttggttcg gctcaaatcc catttgaaga gcaatcgtat aagcaccaaa
     1021 gataccgaac tgagccgctg caccgatcaa catcaactta ggattggaga tcaatgcgga
     1081 gaagtcggtc atggccccga taccgaggaa gatcaatggc ggataccatc cagaagtcac
     1141 accctgatag aggatgttca gtacagaccc ttgctcataa atacctacct gaagacctgc
     1201 gtccttgaaa gggatattac cgatcaagat accaaatccg atagggatca aaagcatcgg
     1261 ttcaaactca tatttaatcg ccaggaatat aaacaacaga cctaccagaa tcatgatgag
     1321 atgtcccgga gtagcgttgt atacacctgt ataggtaagg aacagttgta agttctcacc
     1381 taagaatgtt aaaaagctct cttgcatagt cttatccgat tactacgaga tcagcacctt
     1441 ctagcacaga gtctcccttg tgtactttaa tttctataat cttaccgtca cggtctgcgt
     1501 tgatgttgtt ctccatcttc atagcctcaa ggataatcaa tgtttgacct ctcttcacgg
     1561 tatcacctac gttgcactta acctgcaaga taacacctgg cagcggagtc ttaacagcac
     1621 cttgtgtagt agaggctgcc ggacgagtaa ctacagggtc gccacttgct gttgtcggtg
     1681 cttgagccgg acgtttcaat gtaaccattt gtttcttcgc cggtttctct aattttactt
     1741 gataaggtgt accatttact tcaacatctg cgatgtcatc cactacagaa ttgatgtgta
     1801 ctttatatac gttaccgtta atggtatatt taaaactttt cattctttgt tcgtttttag
     1861 ataattactt atgtggggtt tgacgcaaac cgtagagttt tgaactccaa ggagaataag
     1921 tcctttgtac cttgtggatc gtaagaaccg tgtgctcgat gtcatgattg tcatcactca
     1981 tctcgtacaa agcggtagcg atagcggcaa agatctcacc agactcttgt ccggcgtcaa
     2041 ccgatacact tgttgttccc gcagcttttt gagcgttacg tttgctcgcg gatatagaca
     2101 atctaccgat ctgcttaaag atgatgtata acaaaaataa tcccaagaac actacagcca
     2161 tagcggtaat ggtcataccg atacctaaag agtcattctg tttgaaatta tcgattttct
     2221 cattagaatc caatgttagg ttattcgtac tgggagtaac tttcttcagc tgtgcccatt
     2281 catctttacc atcgatcact ctaccgtaac tgatatcagc catttgtccg gcagggatcg
     2341 taacttcgtc gatcaatgtt ttaccatctg catcatacag agctatataa ttctccttag
     2401 agggatctaa tacgaagtta acgtggaatg tacctctgcc cggctgtccg tcagcccaaa
     2461 atagtgtgtg ctggcggggt tggatctgag tcaatacgtc tcccttcggg atcggatatt
     2521 tcatcggatt gtttttgtcg tctgtcaaat aacatcccgc gatatttacc gttccggccg
     2581 aagtgttgaa caactcaatc cagccatgac gtttgccata gtcgtcaacg aagttatcct
     2641 cgttgataac caatacttca ttaatacgca tggaggttgc gcgctgtgcc tttgccccga
     2701 atgaaatgag caaagcgaac agtagcaata cccctatttt cttatttatc atattcatct
     2761 cctgttttac ggattataga ggcaggttat catgtttctt agcaggattg cttaacttct
     2821 tagtctgcaa ttgctgcaaa gcacgaataa tacggaaacg agtgttacgc ggttcgataa
     2881 catcgtcgat ataaccgtat tgagctgcgt tataaggatt agcgaatgct ttcttatatt
     2941 cagcttcttt ctctgctgcg catgctttcg gatcttcagc ggctgctact tccttggcga
     3001 agataacctc tacggcaccg ctcgggccca taacggcgat ctcggctgtc ggccatgcgt
     3061 aattcatatc accacgtaaa tgtttagaac tcatcacgca ataagctcca ccgtaagact
     3121 tacgcaatgt aacggtaatc ttaggaacgg tagcctcacc ataagcgtaa agcaatttag
     3181 cgccgtgaag gattacaccg ttgtattcct gacctgtgcc cggaaggaat cccggaacgt
     3241 caaccaatgt taccaaagga atattgaaag cgtcgcagaa acgaacgaag cgacctgctt
     3301 tacgagatgc gttgctatcc aagcatcctg ccataacctt cggctggtta gctacgatac
     3361 cgacggattg tccgttgaaa cgagcgaaac ctacgatgat attcttagcg tagtccgcat
     3421 ggacctctag gaactcgttg ttatcgacga tcgtaccgat aacctcatac atatcgtaag
     3481 attggttggc gttatcggga atgatatcgt tcaatacatc atccagacga tcgatcgggt
     3541 ctttgcactc aactaacggc gtttcctcta agttgttctg aggtaagaaa ctgagcaatt
     3601 tacgaatcaa ttgcaaacca tcttcttctg tatcgacagc gaaatgggct acacccgatt
     3661 tggtagtgtg tacgctggct ccacccaact gctcttgggt tacatcctca cctgttacgg
     3721 tttttacgac tttcggacca gtcaagaaca tatagctggt accacgtgtc atgatgttga
     3781 agtctgtcaa agccggagaa taaacggctc caccggcgca agggccgaag ataccggaaa
     3841 tctgaggaac aacaccggaa gccaagatgt tacgttggaa aatctcagcg tatcctgcca
     3901 aggcatttac tccttcttgg atacgagctc caccggagtc gttcaaaccg ataacgggag
     3961 cgcccatctt catggcttga tccattactt tacagatctt catagccaaa gcctcagaca
     4021 aggctccacc gaatacggtg aaatcttgag cgaagatata taccaaacgt ccgtcgatcg
     4081 taccataacc tgttacgata ccatcgccta aatatttagt tttctcgata ccgaagtttg
     4141 tacaacggtg ttgaacaaac atgtcgaatt cctcgaaact accttcgtca agcaacatgg
     4201 cgatacgctc acgagcggta tatttgcctt ttttgtgctg tgattcgatt cttttctctc
     4261 ctccacctaa gcgagcttgc tcacgaagtg cgatgagctc ttttactttt tcaagctggt
     4321 tactcattgt attttgattt gttgttagaa atgaacggat taattatttg ttgcccggca
     4381 tgcaaagctc tgtcaatacg ctgcaagttg atttcgggtg aaggaaagcg atgttcaagc
     4441 cttccgcgcc accacgggga gctttatcga ttaatttaac gcctttttcc tcagcctcgt
     4501 tcaaagctgc ctgtacatca ggtaccgcga atgcgatatg gtggatacct tcaccttttt
     4561 tctcgataaa ttttgcgatc gtgctatctt cgctggtcgg ctctagtaat tcaatcttag
     4621 tctgtcctac cttgaaaaat gcggttttta ctttttggtc tgctactact tcgatattgt
     4681 agcattttaa tccaagaacg ccttcataat agggtaaaca agcctcgata ctcttcactg
     4741 cgatacctaa atgttcgata tgtgtaagtt ccatgtcaat aataatttaa agatttagta
     4801 aatgtttgtt tctattgtgt gcaaatgtac actacttttt atgaatgagg aaataatttt
     4861 ttgtttttat ctcccagtaa atgtgtttaa agatacattt tattaaaaat cgacaatcag
     4921 acgaacgttc aattgacgtc cggtcagata gtttggaact gcgtattgga cattatatac
     4981 atctgttatc caatagtagg aactaacgtt tttgatgtct aatatgttaa atacatccag
     5041 acctagccaa atgtttttca aatggcggaa gaagcccctg tccatgatag cgtccgtgcc
     5101 tcctgccaat tgataggaga ggccgatatc tacacgtttg taggcgggcg tacggaaata
     5161 gccggcttcg tatcctttgc ccgggattgt ctggggaagt cctccggata gaactccttt
     5221 cagatttagc ttgactcgtt tatagcccgg gaaataatct tggaagaaga gtgagatgtt
     5281 gtagccttgg ctattggcca taggaacggt cgttgtttcc cggatggttt gctgggcttt
     5341 catcaaggag aagctgatcc atgagtcggt acccggtacg aattctccga agaatttgac
     5401 atcgagtccc atggcgtaac ctttggcgca gttctcaccg taatagcgga tcttgacgtt
     5461 atctacggtg tagggattca gattgtccag ctttttatag tacatctcgg cggtcacctt
     5521 gaaattccgg tctacggcac ggaacgtata atctcctccc aatatgaaat ggatggagcg
     5581 ttgtgacttt agatctttgt tcaataccgt gatattattg ccgttcttat ctttgtctac
     5641 tctacgtaat tccttgtaga agggcgattg ataatacagt ccggtggcga aacggagcgt
     5701 caagtcttgg tcgaagttcg ggataaagcc caatgaggca cggggactga aaaggaactc
     5761 cttattataa gtccaataac tacctctaac ccctgcgact aacgtgaaca gaccttgctt
     5821 ggtcctgaat ttgaatgcgt cttgcgcata agcggaaaag cgtgtgcttt ctatctgatt
     5881 atcagaaaag aggttcgaat atacacttac gttattaccg gtttggggca aagaataacc
     5941 tgaggaatcc cttttttccc attcactgat cttatcattg attttctcca tttgtaccgt
     6001 ggctccccat ttcaacgtat tgtttaaaag gcgggccatc ccatagtgcc cgacattcat
     6061 gacggtggag ttcaaacggt ttcgtgcgtg ctcgtgataa cggcctacgg acatggcggc
     6121 tgacgcgtcg tcattcggat tttccgctcc gttctcgctc agccaatatt ctccggcgat
     6181 atcgtatccc tcttcttcct tgcttttgaa agcggaggct tgaagtccca actctgtgtt
     6241 ctcattgggg ttgtgtttca atgtaagcgc accgaataag gtttggaaac ggtctctttc
     6301 ccttccgtcg aaatagactt tgaagttctt gggatgctcg gctgtaccga aagaggtttc
     6361 ccggctataa ggggtgaatt tataattatt gttagcgagg tttcccaaga aattgatttc
     6421 ccatttaggg gccaattggt acgtgatgta agtttgcaga tcgataaatt tagggtcgta
     6481 ttcagcgtct gtatccatgg tacccaaaat agaccgaccg cttttaaagc ggaaacccgt
     6541 tacttgggta aatttaccaa tagaactgcc tacataagca ttcgcaccca acaagctcgc
     6601 agaagctgag ccttcgaata tcttaggctt tttataggta atatccagca cggaactcat
     6661 cttgtctccg taacgggcct cgaagccacc ggcggcgaaa ttgaccgcct ccgttaggtc
     6721 cggattgata aagctaaggc cctcttgttg tcccgagcga atcagaagtg gacggaatac
     6781 ctcgatccca ttcacataaa cgatattttc atcataacta cctccacgta cggaatactg
     6841 ggaacttaac tcgttattgg acgatactcc ggcaaacgta acgaccaagc tctctatact
     6901 acctccggaa ggatcgggca ataacttgat tttgtccgca tttagggact ccatggtcgt
     6961 ggtctgcttg cggatggcag taacagatac ttcccctaaa tcaaatgagg tatagttcat
     7021 ctgtacgttc aggcgcatat cggcttgtgc cgagggaatg atacgttcag ccttattata
     7081 tcccagacaa gagtaaataa tggagataga atcccccggc gatatggaaa aggaataata
     7141 tcccttctcg ttggtcatgg agccgatcaa cgtgttctta acccggacat tcactaattc
     7201 cagagggtta ccgtcggcgt cacggacata accagtgatt tttatgcggc cttcgccaaa
     7261 ggcactcacg gaaataagta taaatagcag cgcggctatc gcacgaatct tcataatcta
     7321 ttgttcaatt ataaaaatac taacgagaaa aaagaacgat acgtatatat gggtgcaaaa
     7381 aattatattt atatttgcga atcttaatat taaaagagta caaagaacga aaaaaatgga
     7441 gagttttgca acacttatac aaaatagaag aagtacacgt aagtttaccg aacaactact
     7501 ttcacccgag caggtagaac tgatcttgaa agcggcgttg atggctccgg cctcaaaacg
     7561 tagtaatcct tggcagttcg tggtcgtgga agataaggaa atgttgaaga aacttgccgg
     7621 gtgtaagaaa aatggttctg cttttctgga gggttgtgcc ttggccgtgg ttgtcttggc
     7681 gaatgtgatg gaaagcgatg tttggatcga ggacgcttcg gtcgcttcta tttatatgca
     7741 attgcaggcg gaggatttgg gattgggcag ttgctggtgt cagatccgga accgggtaac
     7801 agaggacgag gcggattcga ataattatgt tcgttcgttg ctggatatcc cttatcaatt
     7861 ggatgtcttg tctatcattg gtatcggtta taaggatcag gttcgtaagc cttttgatga
     7921 atcccattta caatgggaga agatacatat aggaaagttc tctcttccgg aagaaaataa
     7981 agaggcggaa gaatgagagt cgtatttgtt ggtgctggaa acttagctac ccggctttcg
     8041 ttggaaatgc gtaagtccgg aatgagtatc gggcaagtgt atagtcacac aagtgagcat
     8101 gctaagattt tagccgatga attgggatgt gggtggactg ttgtcccgga agatattgtg
     8161 gaagatgccg acttgtatgt tttctctttg aaagatgccg tgctccaaga tgttatcgcc
     8221 cgtgtaaaac cgaataacgg tttgtgggtg catacggcag ggagtatgcc aatctctgta
     8281 tttgaaggtc ttacggctag atatggggtg gtttatgcgt tacaaacgtt tagtaagagt
     8341 agggaggtgg atttcaagaa aataccgttc tttttagagg cgaactcgtc tgaagatgag
     8401 aaggtgctgg gagaggtggc tagggcgctc tccagtgatg tccgtttcct ctcctccgag
     8461 aagcgaaaga acttacattt agcggcggtt ttcgcttgta attttacgaa tcatatgtat
     8521 gcgctagctg aaaagatctt ggaagaacag caaataccgg gagaggtctt gctacctttg
     8581 atagacgaga cagccgctaa ggtacatgta atgtcgccgg cgcgagccca aacgggacca
     8641 gctatacgat atgacgagaa tgtgataaac aaacatatgg ctatgcttaa agatccggat
     8701 atgcgaaatc tatatgagct gattagccga agtatacata aggaggctcg acatgagtag
     8761 tataaactat gatttgagaa aaataaaggc ttttgtcttt gatgtagacg gggtgctatc
     8821 ctgcgatgtg attccgcttc acccgaatgg cgatccgatg cgtacggtca atatcaagga
     8881 tggctatgcc ttgcaattgg ccgtgaagaa aggttatgag gtcgctataa ttacgggcgg
     8941 atatacggaa gccgtacaga ttcgcttttc tcgtttagga atacaacata tttatatgcg
     9001 tagcgctgta aaggtgcatg actttaagga ttttatggaa aaaacgggct tgtctcctga
     9061 gcaaatcatg tatgcgggtg atgatattcc tgattatgag gtaatgacgc gagtcggatt
     9121 gccggtggca cctgcggatg cggctccgga gatcaaggag atagcgaaat atatatcctc
     9181 ccggcgaggt ggcgaaggcg tagctaggga cgtgatcgag caaacgatgc gggcgcaagg
     9241 acactggttc ggcgaggagg cttttgggtg gtaaaatttt ggtgaatgtg taacgcttaa
     9301 tcgaataggt tatgttagag aatttaaaaa agtacaagat cgtcttagcc tctaattctc
     9361 cgagacgacg gaatttgtta tctggtctgg atatcgactt cgaggtgagg ataattccgg
     9421 atattgacga gtcttacccg gattctattg actccatgga gatcccttta tatattgccc
     9481 gttcgaaagc ggaggcctat aaatcgacta tggcggatga tgaattgcta atcacggcag
     9541 atacgatcgt ttggacgttt gacggggtta tggggaagcc tgcgaaccgg gaggaagctt
     9601 atgctatgct tcatgctttg tcggatcatg tacatcaggt aataaccggc gtttgtatca
     9661 tgacgaagga caaaaatgta ggcttttccg tcgaatctgc ggtttgtttc gcaaaattgg
     9721 gtgatgaaga gattaattat tatttggata aatataaacc ttatgataaa gcgggagggt
     9781 atggcattca ggagtggatc ggttatatcg gggtagaggc tatcaatggt agcttttata
     9841 acgtgatggg attacctgtg caaaagcttt atcaggaatt gaaacatttt taatctcaat
     9901 tcaaggtaaa gtatttatcc ttcatataat attctatctg atttaatgtg tgcgctaagg
     9961 ctgggggaat cggtaagacg accggtttct ccacattcca ttccgggtca tttatgatca
    10021 tgtcggatag gctgcccgca tgtattaaga taaggcgggt aggggctgag gctataacct
    10081 tatgattggt gttttgcgca agtagcatga aatgatcttt tgccacttcc gctatatgtg
    10141 tcccttcttg gctgtaaata ataagttttc ccgaaaatac gaagattaat agattatccg
    10201 tggttgtggt attaaacagg gaatctccgg ctctcagtat tttgcattca agttgattta
    10261 gataacgctt catgtaggaa cttaaggatt ttcgaggata gccaatgttt ttctgttagg
    10321 aaggtattcc aacatacctt ttgagtaggt gactttctgt tgtccgttgt tgtccgcata
    10381 aataataaaa tactctattt gggggatgga ttgtgccagt agcttcgctt tctcgactcc
    10441 caaaaccatg aaagtcgtag cgtaagcgtc tgctgtcata caatcttccg ccacgatggt
    10501 cgcgctaaga atattttgtc cagcgggata accggtcgcc ggattgatcg tatgggcata
    10561 tttcttacca tccttgatgt agaagtttcg gtagtcacca gaagtagcca cacccccttt
    10621 ttggcataat tgtacgatct cttcaacatc atttgttacg ccacttgtcc ctatttccgg
    10681 cttgttgatg ccgactcgcc aacagtcacc ttgttgattt acgcctttca tggtgacctc
    10741 accacctatt tctaccatgt agttctttac gccttccttt tccagcaggc gggcgatgac
    10801 atcgcaagca taaccttttg cgatggacga acaattcaat agaatccggg gatcttcttt
    10861 gatgattttc tttccttcca atctcacttt ttgataaccg acgaaagcct ttatgctatc
    10921 gatcatctgc ggggttacgc tatccatctt actgaatccg aatccccata gattaattaa
    10981 tggagcacaa gtaatatcaa aagctcctcc tgatttttgg gagatttctt ccgccttatt
    11041 gaatacttcg gtaaaccatt cgtctacctc cacatcctcg ttattattga ctttcgcgat
    11101 cgtggagttg gggttgaaag gatttaagga gaggttaaaa cgttgcagct cgctgtcgat
    11161 cttatcggtt aggatttgct tggccttgta tttgatgtgg taacttgtat gaaaaacaga
    11221 accactctct tcgaaatatt ggcccttgtc cgagcaagcc gtatgcgata agatcaacag
    11281 gctgactaat atggtaatat tcttgcgcat cattatgaaa ttttatgtcg cgaacttaca
    11341 taaaaaattc catatatgcc cctttcatgg gggagacgct attgtgtgta taaatatcaa
    11401 ggattccttt tttatattgt gactctggtt ttatccaatg tgcacgcctt tcggatagga
    11461 tcttttctat ctcttccacg cttctctcaa tactgtcggt accgattata tccaatgttc
    11521 tcgctggaat atcgatacgg atcaagtcat cgttttcaac caaggcgatt ggtcccccct
    11581 cggaagcctc cggggataca tgtccgatcg ccgggcctcg ggtcgctccg gagaaacgac
    11641 cgtcggtgat caatgcgatg gtctctacca actcaggatc ggaggcgatc gcttctgtcg
    11701 tataaaacat ttctggcatt ccacttcctt tcggtccttc ataacggata aataccgctt
    11761 ctcccggatg gattttcttt tgtaataccg cctcaatagc gttctcctca caatcgaata
    11821 ccctcgcttt cagggtgact tgcatcaagc ggggtgaaat cgccgaatgt tttacgactg
    11881 ccccttcggg cgctaaattt cctttcaata tagcgatggc tccttgtgcc ttgatcggtg
    11941 tatgaaaagg tttgataata tcgccaacct ttactcctag ggcaggaaga tatttatggc
    12001 aattctcata gaagccgttg agttgtaaat cttttaagtt ttcttccaat gttttgccgg
    12061 taacagtcat gacgtcgaga tggaggaatt ctttgatttc ttccatgatc gccggtacgc
    12121 ctcccgcata ccagaaatat tcgccgggcc aaaaaccgct gggacgtata tttaaaaggt
    12181 aggggatctt acgatgtatc ttgtcgaaca aatccggtga taactggatt cccagttcat
    12241 gggcgatagc tggaagatga agcaggctgt tgctggaacc cgctatggcg gcatgtacca
    12301 tgatcgcatt ttcaaacgct tgtatcgtca tgatatcgga gggttttaac tcttctttcg
    12361 ccagtccgag tgcatgttct ccggctttac gggcggtttc ttttaactcg ggtaaatggg
    12421 cggggatcaa ggcggagccc ggtaaagcga tgccaagcgc ttctgccatt acttgcattg
    12481 tagaggcggt acccatgaaa gagcaagctc cacaatccgg acatgcgtca cgcttataaa
    12541 ccatgaattg ttcttccgtt atttcttttc gctcgtactg ggcgctatag gtaccgattt
    12601 gttctaacgt gagtaggttg ggaccggctt tcattatacc accaggcatg aatatagcag
    12661 gcatatctag ccgggctatc gccatcaaat gcgcagggac ggatttgtcg caactggcta
    12721 taaagacacc agcgtcgaaa ggagtcgctt ttacatgaat ctccatcatg gcggccatga
    12781 tatcacggga gactaatgag tagttcatac catcgtgtcc ctgcgcctct ccatcacaaa
    12841 tatcagtgac gaagtagttt gcggcacgtc cccccttttc ctttataccg attccggcct
    12901 cgtccaccaa tttatccaga tgggcgcttc ccggatggct atgtccgtaa ctgctttcta
    12961 caatgatttg cggtttactc aattcgtcga ttttccaacc gctgcctagc cggagtgaat
    13021 ccagctccgg cgctagtttt cgtaattgct ggcttttcat gtctattaat taatgtataa
    13081 ggttatttat tcaataaggt atccctagct aaagaataca tgctctatca aaatctttgt
    13141 accgataccg attaagatta aacctccgat gaggtccagc ttcaagtcga ttctcttgcc
    13201 gaatcggtta ccgaaataga cgccgaaggc agagatagcg aaggtgacaa caccgatagt
    13261 cgaggcttgc agcaagagcg gtgattttaa gatcgccaga gagattccta cggcgagggc
    13321 atcgatactt gtcgctattc ccaatccgca taatgtccgg ttacatagag gatcgaattt
    13381 cccgtcttcc tcctcttcct tcgcgctatc gtatatcatt tttccaccta agtaaagcaa
    13441 gagggtaaat gcgatccaat gatcgaaggc gcaaatgtat ttttcgaatc ctaatcccat
    13501 cgtataacca atcacggtca ttccggcttg gaatataccg agcacgctcg ctatcttaat
    13561 aatattaccg gcggtgcagt tgttcttaag aactgcgccg ccggtaactg atactgctag
    13621 gctatccatg gataagccga tcgctagtag cagaacttca atgtataaca tactagaatg
    13681 attcccgttt aataatttct tctatgggct tacgtttctt tggagtctca tcgaataatg
    13741 ccgggtcgga aggatagccg aacggtatca gtacaacagg ctcgatcgtt tccggaattt
    13801 taaaatgttt acggcaaagc tccgtgtcga aattgcaaac ccaacaagta cccaatcctt
    13861 gttcggcagc ggctaaacaa atgtgttccg tggcgatagc cgtatcgata tccatatgat
    13921 ccttatgatc gccccgtttc caagattgct gatgatctcc gcaaacgatc aagtaataag
    13981 gcgcttgctt gaaccattcc cggggatagc attcttgtaa tttagctttt ccttccgcac
    14041 tttgaaccca tacaaaatac caaggttgat aatttaccgc cgaaggggcc aaacgagctg
    14101 cttctaggat ataatcaatc ttttcttgct ctacgttttt gggggcatac tttcggatag
    14161 agcaacgttt tctcgctaat tctaggaaac tcatatctca tcctctattt tatagttatt
    14221 gcgattcgga gaattgcggg aaatcaactc cccgataaag cccgctagga acatctgggt
    14281 tcccagaatc atcgctgtca atgaaatata gaaataaggg gaacttgtaa ccaaaggtct
    14341 tagatctcca gagtacatcg agatcaattt catgctgagt acgattacta gagcgataaa
    14401 accaatgaag aacatagcgc ttccccataa accgaagaag tgcatcggtt tctttccgaa
    14461 tttggaagta aaccaaagcg tgatcaaatc aagataaccg ttcacgaagc gatccaaccc
    14521 gaatttagta gttccgtact tgcgggcttg atgtttcact actttctcgc caatcttgtg
    14581 aaatccggca atcttagcta aataaggtat gtaacggtgc atatcgttat acacctctat
    14641 atttttaatg acaacattct tatacgcttt caatccgcaa ttgaaatcgt gtaagttctt
    14701 tattcccgag aatttacgag ctgtcgcgtt gaataatttc gtggggatcg tcttagacaa
    14761 cgggtcatat cttt
//
