LOCUS       c00020_gnlPro..        13708 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|BNNOCCMB_20.
ACCESSION   c00020_gnlPro..
VERSION     c00020_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-05 05:18:34
            Original ID  :: gnl|Prokka|BNNOCCMB_20
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13708
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13708
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[6487:12454]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      6488..12454
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..13708
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..13708
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             complement(172..564)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) QRPTase_C"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg20_1"
                     /sec_met_domain="QRPTase_C (E-value: 3.9e-43, bitscore:
                     137.2, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNHRIGLFDMILLKDNHVDFAGGIEQAITRAQNYLKEKGKSLKIE
                     IEVRNFDELEQAMKVGGIDRIMLDNFNIENTKEAVRRINGRFEVESSGGITFDTLRDYA
                     ECGVDFISVGALTHSVKSLDMSFKAC"
     CDS             complement(518..1018)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) QRPTase_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) QRPTase_N"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg20_2"
                     /sec_met_domain="QRPTase_C (E-value: 1e-16, bitscore: 51.2,
                     seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="QRPTase_N (E-value: 2.1e-28, bitscore:
                     88.4, seeds: 125, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKLIDDLIKLAFAEDIGDGDHTTLCCIPETAMGKSQLIIKEDGV
                     LAGVEMAKRIFHDFDPELKMTVFIQDGAEVKKGDIAFVVEGKIQSLLQTERLMLNVMQR
                     MSGIATTTRKYAKALEGTKTHVLDTRKTTPGMRMIEKEAVRIGGXXXHEPSHRFVRYDL
                     IER"
     CDS             complement(1022..1393)
                     /locus_tag="ctg20_3"
                     /transl_table=11
                     /translation="MKRLLLTFALIFAFVCAQAADITSISNAFKAGNASSLSGAMDKVV
                     DVALPGSSKKCNGSEAVSMLSSFFSSNKPSGFSVVHHADKKESGFLVGKLPTSSGEYRV
                     NITYRAEGNTAIIQSIRIE"
     CDS             1586..1957
                     /locus_tag="ctg20_4"
                     /transl_table=11
                     /translation="MEVIPDIKNVKNLSEAQQKEKEGELILKALQPGDYLVLLDEKGKE
                     FTSMQFSTYLEKKMHTVPKRLVFVVGGPYGFSEAVYKAASEKISLSKMTFSHQMIRLIF
                     IEQIYRAMTILNNEPYHHE"
     CDS             complement(2064..2384)
                     /locus_tag="ctg20_5"
                     /transl_table=11
                     /translation="MAWILLIIAGLFEIGWPLGFKLASMHSKYFIWFIGLSILSMGLSG
                     YFLYLAQKSIPIGTAYVIWTGIGAIGTVLLGILFFHDSANIFRLLFLSLILIGIVGLKL
                     VH"
     CDS             complement(2397..3473)
                     /locus_tag="ctg20_6"
                     /transl_table=11
                     /translation="VNTFGNIYRLTSFGESHGPGIGGVIDGCPAGIELDTAFIQQELNR
                     RKPGQSRITTPRKEDDEVQFLSGIYEGKTTGTPIGFIIWNKNQHSSDYDNMKTIYRPSH
                     ADYTYQTKYGIRDPRGGGRSSARETIARCVAGAIAKLALKQYGIQIQAYTSQVGPIQLA
                     GSYQDYDLSLTEESDVRCPDPKTASEMETLIAEVKSKGDTIGGVITCXXXXXXXGLGEP
                     VFGKLHATLGHAMLTINAVKGFEYGDGFNAAFFRGSERNDRFFNDNGHINTRTNNSGGI
                     QGGISNGQDIYFRVAFKSVATILMEQETVNMEGEDTILKARGRHDPCVLPRAVPIVESM
                     TAMTLLDYLLIQKTRENF"
     CDS             complement(3577..4152)
                     /locus_tag="ctg20_7"
                     /transl_table=11
                     /translation="MKITANKYVAVTYDLNVGEGEERELMEKATVEAPLKFIYGTGMML
                     PAFEKALNGLEVGGTFNFSIEPAEAYGEYNEEHVLDLPKNIFEVDGKFDAEMIKEGNTV
                     PMMDSNGNRMNGSVLEVKDDIVVMDFNHPLAGETLHFSGEVIDVHEPTAEEIAAFSAPA
                     GGCSCGCDDCGSDCGDNHEGGCGCGGCH"
     CDS             complement(4201..4473)
                     /locus_tag="ctg20_8"
                     /transl_table=11
                     /translation="MYIMENVRFVEEFMKLHLPKIKVYQPQASFLVWLDCRELELSQDE
                     LVHLFKDKAGLALNDGSIFGPGGEGCPRSVLDKAMNALKKAVDKK"
     CDS             complement(4598..5407)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg20_9"
                     /sec_met_domain="Aminotran_1_2 (E-value: 1.5e-31, bitscore:
                     99.8, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LTPIAIKKLIVNKNMKHYNFDEVIERHGTSCVKFDRLKEMFGDEN
                     LIPLWVADMDFRTPDFIVEALKKRCEHEIFGYTFGSDEYYESIINWVHYKHNWKIQREW
                     ISYIPGIVKGIAFAIQCFTQKGDKVIIQPPVYHPFRIVPEKMKREVVYNPLKMVDGVYE
                     MDFDHLESIIDDKCKVLILCNPHNPGGIVWKKETLVRLAEICAKHNILVISDEIHAEMA
                     YPQXXXXYALSIRLRIGYCRFLQPNFHGTEQDVQYRRYRDFLRNRSQ"
     CDS             6488..8323
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ILVD_EDD"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg20_10"
                     /sec_met_domain="ILVD_EDD (E-value: 8.2e-217, bitscore:
                     710.8, seeds: 918, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNPLRSSFSTEGRRMAGARALWRANGMKEEQFGKPIIAIVNSFT
                     QFVPGHTHLHEIGQLVKAEIEKQGCFAAEFNTIAIDDGIAMGHDGMLYSLPSRDIIADS
                     VEYMVNAHKADAMVCISNCDKITPGMLMASMRLNLPTVFVSGGPMEAGELDGRHLDLID
                     AMIESADTSVSDERIEQVERHACPGCGCCSGMFTANSMNCLNEAIGLALPGNGTIVATH
                     KNRIQLFRDAAKQIVENAYKYYRDGDDSVLPRNIATRQAFLNAMSLDIAMGGSTNTVLH
                     LLAVAQEAGADFHMEDIDMLSRKTPCLCKVAPNTHTYHVQDVNRAGGILGIMNELMKAG
                     LVDGSTRRADGLTLAEAVDKYAVTSPNVTEEAIRKYKSAPAHRFSIQMGSQESYYKELD
                     TDRAEGCIRDVEHAYSKDGGLAVLRGNIALDGCVVKTAGVDESIWKFSGPAKVFDSQDA
                     ACEGILGGKVVSGDVVVITYEGPKGGPGMQEMLYPTSYIKSRHLGKECALITDGRFSGG
                     TSGLSIGHISPEAASGGAIGLVRDGDIIEINIPERSINVRLSDEELAERRKAEEARGKK
                     AFTPPMRQREVSKALRAYGKMVSSADKGGVRIVED"
     CDS             8357..10060
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg20_11"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.1e-50, bitscore:
                     161.5, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEKQKITGSEALLKALIAEGVDTIFGYPGGQAIPIYDSLYDYRDQ
                     LRHVLVRHEQGATHAAQGYARVSGKVGVTLVTSGPGATNTITGIADALMDSTPMVVIAG
                     QVPSPLLGTDAFQEVDVIGITQPITKWAYQIRKPEEIAWAVSRAFYIASTGRPGPVVLD
                     LAKDAQVGLVEYEYKKVDYVRSYQPEPDINKDRIKAAADLINEAKKPFCLVGQGVLLGG
                     AEEELKAFLQKNDIPAGSTVLGLSALPTDFPLNKGMLGMHGNVGPNRKTNECDVLIAIG
                     MRFDDRVTGDLKTYAKQAKIIHLDIDNSEIGKNVAVDVKVLGNAKHTIPMITALLEERK
                     RPEWNAEFDRDEKEEYDKVIEKELYPTEGQLKMGEVVRKVSEATGNDAVLVTDVGQNQM
                     MGVRYFKYKQTRSVVTSGGLGTMGFGLPAAMGAKFGAPDRTVCFFTGDGGMQMTIQELG
                     TIMQEKLNVKIIILNNNFLGMVRQWQELFFHERYSNTIMENPDFVAIAKAYGIAGRAVE
                     KREELDDAIAEMLNHDGAYVLVANVETCGMVYPMVPAGGSVTNMIMGDEK"
     CDS             10076..10630
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg20_12"
                     /sec_met_domain="ALS_ss_C (E-value: 2e-17, bitscore: 53.4,
                     seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTKKLYTVIIFSENIVGLLNQITIIFTRRQLNIETLSVSPSAIK
                     GIHKFTITTFADEDMIDKVVKQIDKRVDILKAYYNTDEDLVYQEIALYKLSTELFIKMG
                     TVEGLIRKYNARILEMNETCVVLEKSGHYDETQALFNELSETIGVLQFIRSGRVAITKS
                     KVERLSDMLADMERKLHEKQQ"
     CDS             10637..11362
                     /locus_tag="ctg20_13"
                     /transl_table=11
                     /translation="MEKVGLFHFVAEPYLMDFRGRVTLPMIGNYLIHAASSHAGERGFG
                     FNDMSERHTAWVLSRLAIEMKEYPTAFDKINLYTWIDEVGRLFTSRCFELADENGKTFG
                     FARSIWAAIDVETRRPTLLDVEALGKYIDERPCPIEKPGKIMPAENKAEGIPYSIKYSD
                     LDINGHFNSVKYIEHLLDLFDIDQFKTREIGRLEIAYQSEGKQGMPLTLHKAESAPDKQ
                     DMAICHEGKAICRAAVTWR"
     CDS             11412..11552
                     /locus_tag="ctg20_14"
                     /transl_table=11
                     /translation="MAQMNFGGVVENVMTREEFPLEKAREILKDETIAVXXXXXRDRDS
                     H"
     CDS             11549..12454
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: IlvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg20_15"
                     /sec_met_domain="IlvN (E-value: 8.6e-38, bitscore: 119.6,
                     seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="IlvC (E-value: 2.4e-40, bitscore: 128.3,
                     seeds: 295, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LNLRDNGFNVIVGQRQGKTYEKAVEDGWVPGETLFGIEEACDKAT
                     IIMCLLSDAAVMSVWPTMKPYLTAGKALYFSHGFAITWNDRTGVVPPTDIDVIMVAPKG
                     SGTSLRSMFLEGRGLNSSFAIYQDATGKAMDRTLALGIGIGSGYLFETTFIREATSDLT
                     GERGSLMGAIQGLLLAQYEVLRENGHTPSEAFNETVEELTQSLMPLFAKNGMDWMYANC
                     STTAQRGALDWMGPFHDAIKPVVEKLYANVKCGNEAQISIDSNSKPDYREKLEAELKAL
                     RESEMWQTAVTVRKLRPENN"
     CDS             complement(12610..13449)
                     /locus_tag="ctg20_16"
                     /transl_table=11
                     /translation="MHKGLLVVGRGIGQVMFQGNALSGLLMLIGIACSSWTLALLALAG
                     NIASTLAAYLLGYSREDIREGLYGFNGTLVGIAIGVFMRINIGSISLLLMGSALSSGIA
                     RQFNRQNKLPGYTAPFILSVWILLILCRYLFPSLMLPTVATPPGHVPDLLHAFTANIGQ
                     VMFQGNMLTGLFFLLAILVNSRLNAAYTIWGASLPLGMILLPATSIADFNMGLLGYNGV
                     LCAIAAGNHLSIRSLIRATLAILLSIGLQIGGMRLGITTLTAPFVLSVWITNLIIKE"
ORIGIN
        1 ataatttgtt cttaaaagta cgggaaagga aggaatggta atgttttaaa aatgataata
       61 gttctatcag aaatgatagt gaatcaagat aatagggtag atatagaaaa aacagcctca
      121 agaagttgat cttctcaagg ctgttttttt atagaatgat cgtttttcgt tttagcaggc
      181 tttgaagctc atatccaagc tcttcacgga gtgagtcaaa gcccctacgg agatgaagtc
      241 tacgccacat tccgcgtaat cacgtaatgt gtcgaacgtg ataccgccgg aagactctac
      301 ctcgaaacgt ccgttgatgc ggcgaaccgc ttcttttgta ttctcgatat tgaaattatc
      361 caacatgata cgatcgatac cgcctacttt catggcttgt tccaactcgt cgaagttacg
      421 aacctcgatc tcgatcttta ggctctttcc tttctctttc agatagtttt gcgcacgtgt
      481 gatcgcttgc tcgatgccgc cggcgaaatc cacatgatta tctttcaata agatcatatc
      541 gaacaaaccg atgcgatggt tcatgnnnnn nnnnnccacc gatacgtacg gcctctttct
      601 cgatcatacg cataccggga gttgtcttgc gagtatccaa aacgtgtgtc ttggtgcctt
      661 ccaacgcctt ggcgtattta cgagtcgtag tagcgatacc gctcatgcgt tgcataacgt
      721 tcagcatcaa ccgctcggtc tgcaataagg attggatctt accttccacc acgaacgcta
      781 tatccccttt tttcacttcg gctccgtctt gtataaagac cgtcattttc agttccggat
      841 cgaagtcgtg gaagatacgt ttagccattt ccacgccggc caatacgcca tcttccttga
      901 tgatcagctg gcttttcccc atcgctgtct cggggatgca acataaggtg gtatgatcac
      961 catcgccaat atcctcggca aacgctaatt tgattaagtc gtcaataagt ttgtccatct
     1021 tttattctat tctgattgat tgtataatcg ctgtatttcc ttcggcacgg tacgtgatgt
     1081 ttacacggta ctcaccggaa gacgtcggaa gctttccgac aaggaaaccg ctttcctttt
     1141 tatccgcatg atgtacgacc gagaatccgg aaggcttatt cgaactgaaa aatgaggaca
     1201 acatagagac ggcctcactt ccgttacatt tcttagagga accgggcaag gctacatcca
     1261 ccaccttatc catagcaccg gatagagagg aggcatttcc tgccttgaaa gcatttgata
     1321 tactggtaat atccgccgcc tgcgcacata cgaatgcgaa tatcaaggcg aatgtaagta
     1381 agagtcgttt cataagcttt ctttatttta ttgagtaatt agtggcaaag gtatgtattt
     1441 ttcttgtaac ttagcctttc taaacctgta aatgtaagta gatgaagatt ggactnnnnn
     1501 nnnnnnnnnn nagacggatg ccggttattt tgtggaggct atcaatgagt ataaaaatcg
     1561 cttgacgcat tatataccct ttgaaatgga agtcataccg gatataaaga acgtgaagaa
     1621 cctctcagag gcgcagcaaa aggagaaaga gggcgaattg attttaaagg ctttgcagcc
     1681 cggcgattat ttggtgttgc tggacgagaa agggaaggag ttcacctcca tgcaattttc
     1741 tacttatctg gaaaagaaaa tgcatacggt cccgaaacgc ttggtatttg tggtgggcgg
     1801 tccttacggt tttagtgagg ccgtgtataa ggcggcatcg gaaaagatct cgttgagcaa
     1861 gatgactttt tcccaccaga tgatccgatt gatctttatc gagcagattt accgggcgat
     1921 gacgatcttg aataacgagc cttaccatca tgaataaccg catcgtttaa cgccggtatc
     1981 cgcatagccc tacgcctata ctggcgtaag ttcacaccga tactgccgtg aggctatgcg
     2041 aatactggtg tttttctccc ggattaatgg actaatttca ggccgacgat ccctatcaat
     2101 atcaaggata agaacaataa tctgaatata ttcgcggaat catggaaaaa caagattcca
     2161 agaagaacag tccctatagc cccgatcccg gtccagatta cataagccgt accgatcggg
     2221 atgcttttct gggcgagata taagaaataa ccgcttaagc ccatggataa gatcgataaa
     2281 cctataaacc aaataaaata tttggaatgc atacttgcta atttaaagcc cagcggccag
     2341 ccgatctcga ataatccggc tataattaac agaatccaag ccatatagaa ttagtcttaa
     2401 aagttttccc gtgtcttctg gatcaataaa taatccaata aagtcatggc ggtcatagac
     2461 tcgacgatag gtaccgcacg aggcaatacg catggatcat gacgtccgcg tgcctttaat
     2521 atcgtatcct ctccctccat gttaaccgtt tcttgttcca tcaagatcgt agcgaccgat
     2581 ttaaaggcta cccggaaata aatatcttgt ccgttggaga tccctccttg gataccgccg
     2641 gaattattgg tacgagtatt gatatgcccg ttatcattga aaaagcgatc gttcctttcc
     2701 gatccgcgga agaaggcggc gttgaatccg tctccatact cgaagccctt cacggcgttg
     2761 atcgtaagca tcgcatgtcc caatgtggca tgtaacttgc cgaacacagg ctctcccaat
     2821 ccgannnnnn nnnnnnnnnn nncacaggta ataacaccgc cgatcgtatc tccttttgat
     2881 ttgacctcgg cgatcaaggt ttccatctct gaggcggtct tcgggtccgg gcaacgtacg
     2941 tcgctctcct ccgtcaagct taaatcataa tcttggtaac tacccgctaa ttggatcggg
     3001 ccgacctgcg aggtataagc ttgaatctgt atgccgtatt gtttaagggc gagtttagcg
     3061 atagccccag ccacgcaacg agcgatcgtt tcccgggcgg acgaacgtcc acctccacgg
     3121 gggtcacgga ttccatattt cgtttgatag gtataatcgg catgggaagg acggtaaatc
     3181 gttttcatat tgtcatagtc cgaggaatgt tggtttttgt tccagatgat gaaacctatc
     3241 ggcgtgccgg ttgtctttcc ctcgtagata ccggaaagaa actgtacctc atcatcctct
     3301 ttacgggggg tcgtgatacg ggattgtccc ggtttacgac ggttcagctc ttgctggatg
     3361 aatgccgtat ctaattcgat cccggctggg catccgtcga tcacgccgcc gataccgggg
     3421 ccgtgcgatt cgccgaacga tgttaatcta taaatattac caaaagtatt caccgttttg
     3481 tctaattgaa aattgaaaac tgaaaattga gaatcaaaag ccgatgatta ggcgtttctc
     3541 ctaattttca attttcaatt ctcaatttcc cattatttag tggcatccac cacaaccaca
     3601 accaccctcg tggttatcgc cacaatcgct accgcaatcg tcgcaaccgc aactgcatcc
     3661 acctgcggga gcggagaagg ctgcgatctc ttccgcagtc ggttcgtgta cgtcgattac
     3721 ctcgccgctg aagtgcaaag tctcgccagc caacggatgg ttgaagtcca ttaccacgat
     3781 atcatccttc acttccaata cagagccgtt catacggttg ccattagaat ccatcattgg
     3841 gacggtatta ccttccttga tcatctcggc gtcgaattta ccgtccacct cgaagatatt
     3901 cttcggaaga tccaatacgt gctcctcgtt atattcgcca taagcctcgg ctggctcgat
     3961 ggagaagttg aacgtgccac ctacttccag cccgttcaag gctttctcga atgccggaag
     4021 catcatgcct gttccgtaga tgaatttcaa aggagcctcg accgtcgctt tttccattaa
     4081 ctcacgttct tcaccttcgc caacgttcag gtcgtatgta accgcaacgt atttgtttgc
     4141 tgtaattttc atttgtcttg tattttaaat atgtatagaa atgctcgcaa agatacgatt
     4201 ttatttctta tccaccgcct ttttaagagc gttcatcgct ttatctaaaa cagagcgggg
     4261 gcaaccttct cccccggggc cgaagatact tccgtcgttc agcgctagtc cggctttgtc
     4321 tttgaacagg tgtacgagtt catcttgact taattccagt tccctgcaat ccaaccaaac
     4381 gaggaaggag gcttggggct ggtaaacttt tatcttgggg agatgtagtt tcatgaactc
     4441 ttccacgaaa cgtacattct ccatgatata cattcgcatt tgttgcaacc attcggcacc
     4501 ataggtgtaa gcggcggttg tcgccgtata agcgaagatc gtgccatcgc caaactctcc
     4561 ggcctcaagg aaagaataaa attcttcccg gatgcgatca ttgggaacga ttgcgtagga
     4621 agtcacgata ccggcgatat tgaacgtctt gctcggtgcc atgaaagtta ggctgcaaga
     4681 agcggcagta tccgatacgg aggcgaatgg ataatgcgta tannnnnnnn nnctgaggat
     4741 aggccatttc cgcatgaatc tcatcggaga taaccaaaat attgtgcttg gcgcaaatct
     4801 cggccaatcg gaccaaggtt tcctttttcc agacgatccc gcccggattg tgagggttgc
     4861 agaggatcaa taccttgcat ttatcatcta taatagattc aagatgatcg aaatccatct
     4921 cataaacacc atctaccatc tttagcggat tataaacgac ctcacgcttc attttttccg
     4981 gaacgatgcg gaacggatga taaacagggg gctggatgat gaccttatct cctttttgcg
     5041 taaagcattg gatagcgaaa gcgattccct tcacgattcc cgggatatag ctgatccatt
     5101 cccgttgtat tttccagtta tgtttgtagt gtacccaatt gatgatactc tcgtaatact
     5161 cgtcggagcc gaatgtatag ccgaatatct cgtgctcaca acgtttcttc agggcctcta
     5221 caataaagtc cggtgtgcgg aaatccatat ccgccaccca tagtggtatc agattctcgt
     5281 caccgaacat ctctttcaaa cggtcgaatt tcacgcaact cgtcccatgc cgttcgataa
     5341 cttcgtcgaa gttgtagtgt ttcatatttt tattaacgat cagtttctta attgctattg
     5401 gggtcaaaga tacaaattat tatatttatt gtttatccaa atcaaaatat gaaatactgt
     5461 atattaggaa atcggcgata tatttaatga atcgtttact taaacggctt atcaaaccgt
     5521 gaactggcaa aatgtcaaag tgctattatt gctctctgtg ggtgatgaat tatggggcgg
     5581 gggcttggtc gcacggaaaa agcgcaagca tttgatggtt gtgtaaatca gaatgatgtt
     5641 tgaatgcagg tcttgttggt ctttttttat gattgatgtt tgaagagctg tctatcggtt
     5701 gagtatttaa ggctttctct gtctgaaagt cattttgaaa atgtcttcgc ttgagctgct
     5761 tctagcgtgg gttatgccgg atttagtctt gattttaggt gattttcatt cggatgttaa
     5821 caaaatttag tccgatacta gatgaaattt attccttatg ttcttcagaa aacttcctta
     5881 tgttttttct agaacactat tatgaatttt ttcaaggcta tttatagtct acaagtgtta
     5941 ataaatatgt gatttagagt ttatatgtat cttttttatc gctagaatag gattttctta
     6001 tgagatacgt gttatcgtaa gtcgtgttat ctgataaaaa tgttatctgg aatctgtttt
     6061 agataacatt tgtcttttta ctgtttctgt ttggaaatcg aagttttttc ccttctatac
     6121 cttccgattc ctaagtaata cactcttgct cctgttaaaa tgcaatccta aaatggtatt
     6181 tgcttgagaa ttgaaagaaa aatgaagaat tttcttttaa atcctttgcg catatcaatt
     6241 attgttctac atttgcagcg tcaaacaaac aaagacaata agaaaagatg atgaacaacg
     6301 tattgcatat tattctcgtg gtggtccttc tagtcattag taggtaagga gaaaggtgtg
     6361 taagaagttg tgaagtcgta gagatatttc ttaagccttt ctccatatag ggaaaggctt
     6421 ttttattata aataaatcaa ggtagaggcg tggataaagc gctctacgaa caaaaaatag
     6481 gaaagagatg aagaatccgt taagaagctc atttagcacc gaaggtcgta ggatggccgg
     6541 agcccgtgcg ctatggcgtg ccaacgggat gaaagaggaa cagttcggca agcctattat
     6601 cgctatcgta aattcattta cccagttcgt gccggggcat acgcatttgc atgagatcgg
     6661 gcaattggtc aaggccgaga tcgagaaaca aggttgtttc gccgctgaat ttaatacgat
     6721 cgctatcgac gacggtatcg ctatggggca cgatgggatg ctttactcgc ttccttcacg
     6781 cgacattatc gcggacagcg tggaatatat ggtaaatgcc cataaggcgg acgctatggt
     6841 ttgcatcagc aattgcgata agatcacgcc gggtatgctt atggcttcca tgcgattaaa
     6901 tctcccgacg gtgttcgtgt ccggtggccc gatggaggca ggtgagctgg atggccgcca
     6961 tcttgatttg atcgatgcga tgattgagtc tgccgataca tcggtaagcg atgagcgtat
     7021 cgagcaggtg gaacgccatg cgtgtccggg ttgcggttgt tgttccggta tgtttaccgc
     7081 taactctatg aactgcttga acgaggcgat cggtctggcg cttccgggta acgggacgat
     7141 cgtggctacc cataagaacc gtatccaact tttccgtgac gcggctaagc aaatcgttga
     7201 gaacgcttac aaatactatc gtgacgggga tgattccgtg ttacctcgca acatcgctac
     7261 ccgtcaggct ttcttgaacg ccatgtcgct ggatatcgcc atgggggggt ctaccaatac
     7321 agtgcttcac ttattggccg tggcacaaga agccggcgcc gattttcata tggaggatat
     7381 cgatatgtta tcccgcaaga ctccttgcct gtgtaaggta gccccgaata cgcacactta
     7441 tcatgtacaa gacgtaaacc gtgccggtgg aatcctcggt atcatgaacg agttgatgaa
     7501 agccgggctt gtggatggca gcacgagacg tgcggacggc ctgaccttgg ccgaggctgt
     7561 tgataaatac gccgtcactt ccccgaacgt aacggaggag gcgattcgta aatacaagag
     7621 cgctcccgct catcggttca gtatccagat gggctcccaa gaatcttatt ataaggaatt
     7681 agatacggat cgtgccgaag gttgtatccg tgacgtggag cacgcttatt ccaaggatgg
     7741 cggcttggct gttttgagag ggaatatcgc cttggacgga tgtgtcgtaa aaaccgccgg
     7801 tgtggatgag agtatttgga aattctccgg cccggcgaaa gtcttcgatt cacaggatgc
     7861 cgcttgcgag ggcattttag gaggcaaggt cgtttcaggc gatgtggtcg tcatcacgta
     7921 tgaggggccg aaaggggggc cgggaatgca agagatgtta tatcctacct cttatataaa
     7981 gagccgtcac ttaggtaagg agtgcgcctt gatcacggat ggtcgtttca gtggcggtac
     8041 gtccggtctt tctatcgggc atatctctcc cgaggccgct tccggtggcg ctatcggact
     8101 ggtgagagac ggggatatca tcgagatcaa tatcccggaa cgttccatca acgtgcggtt
     8161 gagcgacgag gagttggccg agcgccgtaa ggcggaagag gcacgtggaa agaaagcctt
     8221 tacgccgccg atgcgtcagc gtgaggtctc gaaagcgttg agagcgtacg ggaagatggt
     8281 tagctccgcc gataagggag gtgtaaggat tgttgaagat taaagccaat aatatacatt
     8341 aaacacgtta tttcttatgg agaaacaaaa gataaccggt tcggaagctt tgctgaaagc
     8401 gctgatcgct gaaggagtag atactatctt cggttatccg ggtgggcagg cgatacctat
     8461 ttacgacagt ttatatgatt atagggacca gttgaggcat gtattggtgc gccacgagca
     8521 aggcgctacc catgcggctc aaggatatgc ccgtgtatcc ggcaaggtag gagtgacgtt
     8581 ggttacttcc ggcccgggcg ctacgaatac catcacgggt atcgctgatg cgctgatgga
     8641 tagtacgcca atggtcgtaa tcgccggtca agtaccctcg ccgttgttgg gaaccgatgc
     8701 ttttcaggaa gtcgacgtga ttggcatcac gcaaccgatc acgaaatggg cttatcaaat
     8761 ccgcaagccg gaggagatcg catgggctgt ttctcgtgct ttttatatcg cttctacagg
     8821 ccgtccgggt ccagttgtgc tggatttagc gaaggacgcg caagtagggt tggtggaata
     8881 tgaatataag aaggtcgatt acgtacgtag ttatcaaccg gagccggata tcaataagga
     8941 tcgtatcaag gccgccgccg atttaatcaa tgaggcgaag aaacccttct gtctggtcgg
     9001 acagggagta ttgttaggcg gtgcggaaga ggaattgaaa gcgtttctcc aaaagaatga
     9061 tatacctgcc ggatctacgg tattgggctt atctgcgttg ccaaccgatt tcccattgaa
     9121 caagggaatg ctcggcatgc atggaaacgt agggccgaac cggaaaacga atgagtgtga
     9181 tgtattgatc gctatcggta tgcgtttcga cgaccgtgtg actggcgatt taaagacata
     9241 cgctaagcaa gccaagatta tccatctgga tatcgacaac tcggaaatcg gcaagaatgt
     9301 tgccgtggac gtaaaggtgc tggggaatgc caagcacacg ataccaatga tcacggcgtt
     9361 gttagaagaa cgtaaacgtc cggaatggaa tgccgagttc gatcgggacg agaaagagga
     9421 atacgataag gtaatcgaga aggaattgta tccgaccgag ggccaactga aaatgggcga
     9481 ggtagtccgt aaggtttccg aggcgaccgg taacgacgct gtattggtga ccgacgttgg
     9541 gcagaaccag atgatgggcg tccgctattt caaatataaa caaacccgta gcgtggtgac
     9601 ttccggtggt ttaggtacga tgggatttgg tctgccggcc gctatgggcg ctaagttcgg
     9661 agctccggac cgtacggtct gcttctttac cggtgatggg ggtatgcaga tgacgattca
     9721 agaattgggt accatcatgc aggaaaaact gaacgtgaag attatcattc ttaataataa
     9781 cttcttaggt atggtacgtc agtggcaaga attgttcttc cacgagcgtt attcaaacac
     9841 catcatggag aatccggatt tcgtggcgat cgctaaagcc tatggtatcg ccggccgtgc
     9901 cgttgaaaag cgggaggagc tggacgacgc tatcgctgag atgctaaacc acgacggcgc
     9961 ttacgtgttg gtcgctaacg tggagacttg cggaatggta tatccgatgg ttcctgccgg
    10021 gggaagcgtg acaaacatga ttatgggaga cgagaaataa ggaggagatg aagctatgac
    10081 aacaaagaaa ttatataccg ttattatctt ttcagagaat atcgtaggtc ttttgaacca
    10141 gataacgatt atctttacac gccgacagct gaacatcgag actctgtccg tctctccgtc
    10201 cgctatcaag ggcatccata agtttacgat cacgacattc gccgatgagg atatgatcga
    10261 taaggtggtg aaacagatcg ataaacgtgt ggatatcttg aaggcttatt ataatacgga
    10321 tgaggatttg gtttatcaag agatcgctct ttataagcta agtaccgagc ttttcatcaa
    10381 gatgggaacc gtggagggat tgatccgtaa atacaacgct cgtatcttgg agatgaacga
    10441 gacctgcgtg gtattggaga agagtggcca ttatgacgag acacaagcct tgttcaatga
    10501 gttgagcgag acgatcggtg tcctgcaatt catccgctcc ggacgtgtgg ctatcacgaa
    10561 gagcaaggtg gagcgcttga gcgatatgtt ggccgatatg gagcgaaagt tacatgaaaa
    10621 gcaacaataa taagatatgg agaaagtagg attatttcat ttcgtggcgg agccgtattt
    10681 gatggatttt aggggacgtg taacgctccc tatgattggt aactatttga ttcacgccgc
    10741 ttccagccat gccggagagc gtgggttcgg tttcaatgat atgtcggagc gtcatacggc
    10801 ttgggtgttg tcccgtctgg ctatcgagat gaaggaatat cctaccgcct tcgataagat
    10861 taatctatac acttggatcg atgaggtcgg acgcctcttc accagccgtt gttttgagct
    10921 ggcggatgag aatgggaaaa cctttggatt tgcccgttct atttgggcgg ctatcgacgt
    10981 ggagacccgc cgtcctacct tattggatgt agaggcattg ggcaaatata tcgacgagcg
    11041 tccgtgcccg atcgagaagc cgggcaagat catgccggcg gagaataagg cggagggaat
    11101 cccgtattcg atcaaataca gcgacttgga tatcaacggt cacttcaata gcgtgaagta
    11161 tatcgagcat ctgctggatt tgttcgatat cgaccagttc aagacccgtg agatcggccg
    11221 tctggagatc gcctaccaat ccgagggtaa acaaggtatg ccgcttacgc ttcataaggc
    11281 ggagtccgct cccgataagc aagacatggc tatttgccat gagggaaagg cgatctgtcg
    11341 tgcggcggtt acttggagat aataaaagag atacataaat aggtttttaa acattaatag
    11401 ttaaaaagaa aatggcacaa atgaattttg gcggtgttgt agagaatgta atgacccgcg
    11461 aggaatttcc gttggaaaag gcaagagaga tattaaaaga tgagacaatc gctgttatnn
    11521 nnnnnnnnnn cagggaccgg gacagtcatt gaaccttcgt gacaatggct tcaacgtaat
    11581 cgttggccag cgccaaggta agacttacga gaaagcggtt gaggacggat gggttccggg
    11641 tgagactctg ttcggtatcg aggaggcttg cgacaaggcc acgatcatca tgtgcttatt
    11701 gtccgacgct gccgtaatgt ctgtatggcc tacgatgaag ccttatctga cagctggcaa
    11761 ggccctgtat ttctctcatg gtttcgcgat cacttggaac gatcgtacgg gcgttgttcc
    11821 tcccacggat attgacgtga tcatggtcgc tccgaagggg tctggtacgt ctttgcgttc
    11881 catgttcctt gagggtcgtg gcttgaactc ttctttcgct atctatcaag acgctactgg
    11941 caaggcaatg gatcgtacgt tggcgttggg tatcggtatc ggttccggtt atttgttcga
    12001 gacgactttc atccgtgagg ctacttccga cttgaccggt gagcgcggtt ctttgatggg
    12061 cgctatccaa ggtttgttgt tggcccagta tgaggtattg cgcgagaatg gacatactcc
    12121 ttccgaggct ttcaacgaga cggtcgagga gttgactcaa tccttgatgc ccttattcgc
    12181 caagaatggt atggactgga tgtacgctaa ctgctctacg actgcccagc gtggcgcttt
    12241 ggactggatg ggtccgttcc acgacgcaat caagccggtt gtcgagaaat tgtatgcgaa
    12301 cgtaaaatgc ggtaacgagg ctcagatctc tatcgattct aactctaagc cggattatcg
    12361 tgagaaattg gaggctgaat tgaaggcgtt gcgcgagagc gagatgtggc agactgctgt
    12421 taccgtacgc aagcttcgtc cggagaacaa ctaatccaat cttaatcctt atatatcagc
    12481 aaaaagaggc gggtcactta cgggtggctc gccttgcgtg tccttgcggc cttggccgct
    12541 gtttctttta cggggatgtt gcttaatttc gtcatagtcg taatcattat taaatggatg
    12601 atgctggaat cattccttta ttataaggtt tgttatccat acggagagta cgaatggggc
    12661 ggtaagggtc gtgatcccca gacgcatgcc gccaatctgt aatccgatag atagtaagat
    12721 cgccaaggtt gcccgtatca ggctacggat agaaagatgg ttgcctgccg cgatagcgca
    12781 taatacaccg ttgtagccga gcaaccccat gttaaaatca gcgatgcttg tcgccggtag
    12841 taatatcatc cccaatggca gcgacgcgcc ccatattgtg taggctgcgt ttaagcgtga
    12901 gtttactaag atggcaagaa gaaagaatag ccctgttagc atattgcctt gaaacatcac
    12961 ttgtccgatg ttagcggtga aagcatgaag taaatcgggg acatgcccgg gaggagtcgc
    13021 tacggttgga agcatcaacg aagggaatag atatcgacat aggattaata aaatccatac
    13081 cgaaagtatg aatggggctg tatatcccgg tagtttattc tggcgattga attgccgggc
    13141 gatcccgctt gataaggcgg atcccataag aagcagagat atcgacccga tatttattct
    13201 catgaatact ccgatcgcta tacctaccag tgttccgttg aaaccatata gtccttcgcg
    13261 tatatcttcg cgagaatatc cgaggagata ggccgccagc gtgcttgcga tattgccggc
    13321 taacgccaat aacgctaaag tccatgaact acaggcaata cctatcagca ttaatagtcc
    13381 ggaaagagca ttgccttgaa acatcacttg accgattccc cggcctacaa cgagtaatcc
    13441 cttatgcata ccattttagt tttgactgcg aaaataacga aaatagcaca atcacgagcg
    13501 taattcgggc aactgtgcca agattccggt tacgatatgt tttgcggcat gatcgtcaac
    13561 ctgtttcttt tgcgtttttt tgcaaataac cgcttatatt tttgtttgtt aggattaaat
    13621 atctaacttt ggctcttgtt ataagagata cgaatgacac aagtttgcag atatacggcg
    13681 ttaacctttt ttaccgataa atatttgg
//
