LOCUS       c00041_gnlPro..        13606 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|FGCCJLKM_41.
ACCESSION   c00041_gnlPro..
VERSION     c00041_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-05 05:22:00
            Original ID  :: gnl|Prokka|FGCCJLKM_41
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13606
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..108
                     /locus_tag="ctg41_1"
                     /transl_table=11
                     /translation="FIIYADNNGQQKVTYSKGMLEYLPNRKTLAILENP"
     protocluster    1..13606
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[5629:10194]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      5630..10194
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..13606
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..13606
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             117..494
                     /locus_tag="ctg41_2"
                     /transl_table=11
                     /translation="MKRYLNQLECKILRAGDSLFNTTTTDNLLIFVFSGKLIIYSQEGT
                     HIAEVAKDHFMLLAQNTNHKVIASAPTRLILIHAGSLSDMIINDPEWNVEKPVVLPIPP
                     ALAHTLNQIEYYMKDKYFTLN"
     CDS             complement(497..1078)
                     /locus_tag="ctg41_3"
                     /transl_table=11
                     /translation="MLENLKKYKIVLASNSPRRRNLLSGLDIDFEVRIIPDIDESYPDS
                     IDSMEIPLYIARSKAEAYKSTMADDELLITADTIVWTFDGVMGKPANREEAYAMLHALS
                     DHVHQVITGVCIMTKDKNVGFSVESAVCFAKLGDEEINYYLDKYKPYDKAGGYGIQEWI
                     GYIGVEAINGSFYNVMGLPVQKLYQELKHF"
     CDS             complement(1116..1637)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HAD_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg41_4"
                     /sec_met_domain="HAD_2 (E-value: 6.9e-09, bitscore: 26.4,
                     seeds: 51, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSINYDLRKIKAFVFDVDGVLSCDVIPLHPNGDPMRTVNIKDGY
                     ALQLAVKKGYEVAIITGGYTEAVQIRFSRLGIQHIYMRSAVKVHDFKDFMEKTGLSPEQ
                     IMYAGDDIPDYEVMTRVGLPVAPADAAPEIKEIAKYISSRRGGEGVARDVIEQTMRAQG
                     HWFGEEAFGW"
     CDS             complement(1630..2268)
                     /locus_tag="ctg41_5"
                     /transl_table=11
                     /translation="LGCGWTVVPEDIVEDADLYVFSLKDAVLQDVIARVKPNNGLWVHT
                     AGSMPISVFEGLTARYGVVYALQTFSKSREVDFKKIPFFLEANSSEDEKVLGEVARALS
                     SDVRFLSSEKRKNLHLAAVFACNFTNHMYALAEKILEEQQIPGEVLLPLIDETAAKVHV
                     MSPARAQTGPAIRYDENVINKHMAMLKDPDMRNLYELISRSIHKEARHE"
     CDS             complement(2277..2411)
                     /locus_tag="ctg41_6"
                     /transl_table=11
                     /translation="MRVVFVGAGNLATRLSLEMRKSGMSIGQVYSXXXXVTQVSMLRF"
     CDS             complement(2408..2968)
                     /locus_tag="ctg41_7"
                     /transl_table=11
                     /translation="MESFATLIQNRRSTRKFTEQLLSPEQVELILKAALMAPASKRSNP
                     WQFVVVEDKEMLKKLAGCKKNGSAFLEGCALAVVVLANVMESDVWIEDASVASIYMQLQ
                     AEDLGLGSCWCQIRNRVTEDEADSNNYVRSLLDIPYQLDVLSIIGIGYKDQVRKPFDES
                     HLQWEKIHIGKFSLPEENKEAEE"
     CDS             3090..5501
                     /locus_tag="ctg41_8"
                     /transl_table=11
                     /translation="MKIRAIAALLFILISVSAFGEGRIKITGYVRDADGNPLELVNVRV
                     KNTLIGSMTNEKGYYSFSISPGDSISIIYSCLGYNKAERIIPSAQADMRLNVQMNYTSF
                     DLGEVSVTAIRKQTTTMESLNADKIKLLPDPSGGSIESLVVTFAGVSSNNELSSQYSVR
                     GGSYDENIVYVNGIEVFRPLLIRSGQQEGLSFINPDLTEAVNFAAGGFEARYGDKMSSV
                     LDITYKKPKIFEGSASASLLGANAYVGSSIGKFTQVTGFRFKSGRSILGTMDTDAEYDP
                     KFIDLQTYITYQLAPKWEINFLGNLANNNYKFTPYSRETSFGTAEHPKNFKVYFDGRER
                     DRFQTLFGALTLKHNPNENTELGLQASAFKSKEEEGYDIAGEYWLSENGAENPNDDASA
                     AMSVGRYHEHARNRLNSTVMNVGHYGMARLLNNTLKWGATVQMEKINDKISEWEKRDSS
                     GYSLPQTGNNVSVYSNLFSDNQIESTRFSAYAQDAFKFRTKQGLFTLVAGVRGSYWTYN
                     KEFLFSPRASLGFIPNFDQDLTLRFATGLYYQSPFYKELRRVDKDKNGNNITVLNKDLK
                     SQRSIHFILGGDYTFRAVDRNFKVTAEMYYKKLDNLNPYTVDNVKIRYYGENCAKGYAM
                     GLDVKFFGEFVPGTDSWISFSLMKAQQTIRETTTVPMANSQGYNISLFFQDYFPGYKRV
                     KLNLKGVLSGGLPQTIPGKGYEAGYFRTPAYKRVDIGLSYQLAGGTDAIMDRGFFRHLK
                     NIWLGLDVFNILDIKNVSSYYWITDVYNVQYAVPNYLTGRQLNVRLIVDF"
     CDS             5630..6040
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Glyoxalase_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg41_9"
                     /sec_met_domain="Glyoxalase_4 (E-value: 4.5e-27, bitscore:
                     85.0, seeds: 51, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MELTHIEHLGIAVKSIEACLPYYEGVLGLKCYNIEVVADQKVKTA
                     FFKVGQTKIELLEPTSEDSTIAKFIEKKGEGIHHIAFAVPDVQAALNEAEEKGVKLIDK
                     APRGGAEGLNIAFLHPKSTCSVLTELCMPGNK"
     CDS             6077..7630
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Btheta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg41_10"
                     /sec_met_domain="CT_Btheta (E-value: 1.7e-292, bitscore:
                     960.5, seeds: 72, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNQLEKVKELIALREQARLGGGEKRIESQHKKGKYTARERIAML
                     LDEGSFEEFDMFVQHRCTNFGIEKTKYLGDGIVTGYGTIDGRLVYIFAQDFTVFGGALS
                     EALAMKICKVMDQAMKMGAPVIGLNDSGGARIQEGVNALAGYAEIFQRNILASGVVPQI
                     SGIFGPCAGGAVYSPALTDFNIMTRGTSYMFLTGPKVVKTVTGEDVTQEQLGGASVHTT
                     KSGVAHFAVDTEEDGLQLIRKLLSFLPQNNLEETPLVECKDPIDRLDDVLNDIIPDNAN
                     QSYDMYEVIGTIVDNNEFLEVHADYAKNIIVGFARFNGQSVGIVANQPKVMAGCLDSNA
                     SRKAGRFVRFCDAFNIPLVTLVDVPGFLPGTGQEYNGVILHGAKLLYAYGEATVPKITV
                     TLRKSYGGAYCVMSSKHLRGDMNYAWPTAEIAVMGPSGAVEVIFAKEVAAAEDPKACAA
                     EKEAEYKKAFANPYNAAQYGYIDDVIEPRNTRFRIIRALQQLQTKKLSNPAKKHDNLPL
                     "
     CDS             7652..8539
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg41_11"
                     /sec_met_domain="OAD_gamma (E-value: 1.7e-12, bitscore:
                     38.3, seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINKKIGVLLLFALLVSFGAKAQRATSMRINEVLVINEDNFVDDY
                     GKRHAWIELYNGSAGSVNIAGCFLTNDKNNPKKYPIPKGDVLTVIPPRQHTLFWADGEP
                     NRGTFHVNFTLDPSKENYLALYDADGKTLIDEIVIPASQKADISFGRTLDGQGEWTILS
                     KVTPSTNNVTLDSNEKIENFKENDSWGIGMTLTAMAVVFSGLFLLFIIFKQIGKFSIAA
                     SKRNAQKAAGAAVVADNAGQESGEIFAAIGAALYEMSDDNHDIEHTVLTIRKVQRSYSP
                     WSSKIYGLREVPKK"
     CDS             8562..8993
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 64.6; E-value:
                     1.8e-20)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg41_12"
                     /sec_met_domain="Biotin_lipoyl (E-value: 5.9e-21, bitscore:
                     64.6, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKSFKYTINGNVYKVHINSVVDDIAEVEVNGTPYQVKMEKPAKKQ
                     MVTLKRPAQAPTTASGDPVVSRPVASTTKGAVKSPLPGVILQVNCKVGDAVKRGQNLLV
                     LEAMKMENNINADRDGKIIEIKVNKGDSVLEGADLVVIG"
     CDS             8998..10194
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg41_13"
                     /sec_met_domain="OAD_beta (E-value: 2.3e-153, bitscore:
                     500.6, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLGSVLLQAVGATHESFLQFLGKNLELFLTYTGVYNATPGHIIMI
                     LIGLLFIFLAIKYEFEPMLLIPIGFGILIGNIPFKDAGLQVGIYEQGSVLNILYQGVTS
                     GWYPPLIFLGIGAMTDFSALISNPKLMLIGAAAQFGIFGAYIIALQMGFEPNQAGAIGI
                     IGGADGPTAIFLSSKLAPNLMGAIAVSAYSYMALVPIIQPPFMRLLTTQKERLIRMKPP
                     RAVSSTEKIVFPIVGLLLTCFLVPSGLPLLGMLFFGNLLKESGVTRRLAETARGPLIDT
                     ITILLGITVGASTQATQFLTLNSIKIFGLGALSFVIATCAGILFVKFFNLFLKEGNKIN
                     PLIGNSGVSAVPDSARISQNVGLEYDPTNYLLMHAMGPNVAGVIGSAVAAGILLGFLG"
     CDS             complement(10262..10408)
                     /locus_tag="ctg41_14"
                     /transl_table=11
                     /translation="MRRKKTNVLLIIGVVIAIILLMFWLFFGTTLEQEANPETDPMTIE
                     QNI"
     CDS             complement(10505..11248)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_M22"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg41_15"
                     /sec_met_domain="Peptidase_M22 (E-value: 2.7e-24, bitscore:
                     76.7, seeds: 111, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFLYFCIRNQDWQLIMSCILNIETSTSVCSVALSTDGEVLFEKAS
                     FDGPSHAALLGVFVEEALSVLKEKGGKLDAVAVSSGPGSYTGLRILVSVAKGLCFGFGI
                     PLIGIHTLDIIAATAIKENKAIDGCLYCAMLDARRMEVYAAIYDASLKPVRETAADIVD
                     AGTYASYLEKGNVCFVGNGASKCKPVITSPNAIFIEDIHPLAVNMVPLAEQAFAAGRFE
                     DTAYFEPFYLKEFQATVAKNKVLGN"
     CDS             11312..12184
                     /locus_tag="ctg41_16"
                     /transl_table=11
                     /translation="MIQSMTGFGKVTAELPSKKVTVEIKALNSKQLDLSTRIPSAYKEK
                     EMQIRSLLLQSLERGKVEFNIFIEYIGKDTPTQINLAAVENYYTQIKDIADKLNIGLPA
                     DWFQTLLRMPDVIKTEAQEVNEEEWNVVENAIKEAIQHLCDFRIQEGAMLQKLFEQKIA
                     NIGRLLSEVELYEKERIEKVKTRIMDNLEKIAGQDYDKNRFEQEMIYYIEKLDVNEEKN
                     RLDNHLKYYISTMESGHGQGKKLGFIAQEMGREINTLGSKSNHAEMQKIVVQMKDELEQ
                     IKEQVLNVL"
     CDS             12194..12763
                     /locus_tag="ctg41_17"
                     /transl_table=11
                     /translation="MAGKLIIFSAPSGSGKSTIINFLLKQNLNLHFSISATSRAPRGTE
                     KDGVEYYFLTPDEFRTRIAAGDFLEYEEVYTDKYYGTLKSEVERRLVGGDNVIFDVDVV
                     GGCNIKKFYGDRALSVFIQPPSIEDLRRRLEGRGTDTSEVIESRIAKAAFELGFADKFD
                     VIVVNDKLETAQAEALKVIKEFLEKA"
     CDS             12760..12933
                     /locus_tag="ctg41_18"
                     /transl_table=11
                     /translation="MNGKKLSKKWLYTFIGIAFVALATCIAALYYKEYIIATGTGLVFG
                     AQVINIIKWKRD"
     CDS             12918..13511
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) CTP_transf_like"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg41_19"
                     /sec_met_domain="CTP_transf_like (E-value: 1.8e-26,
                     bitscore: 83.5, seeds: 65, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VETGLKENTAGKRKTGIYSGSFNPVHIGHLALANWLCEFTELDEI
                     WFLITPHNPLKEKEELIDDRLRYELVKKSIAGYPKFKVSDIEFSLPQPTYTIDTLRTLD
                     RLYPEREFYFIMGADNWTSISRWKESETIIANYPILIYPRKGYEVKLNNSMPHIRYVEA
                     PQIEVSSTFIRQSLRTGKDVRFFLPEAIRDILQH"
     CDS             complement(13500..13604)
                     /locus_tag="ctg41_20"
                     /transl_table=11
                     /translation="IMDSGFDGYAAKPLNAKMLKQQIGDALKMRLLML"
ORIGIN
        1 tttattattt atgcggacaa caacggacaa cagaaagtca cctactcaaa aggtatgttg
       61 gaataccttc ctaacagaaa aacattggct atcctcgaaa atccttaagt tcctacatga
      121 agcgttatct aaatcaactt gaatgcaaaa tactgagagc cggagattcc ctgtttaata
      181 ccacaaccac ggataatcta ttaatcttcg tattttcggg aaaacttatt atttacagcc
      241 aagaagggac acatatagcg gaagtggcaa aagatcattt catgctactt gcgcaaaaca
      301 ccaatcataa ggttatagcc tcagccccta cccgccttat cttaatacat gcgggcagcc
      361 tatccgacat gatcataaat gacccggaat ggaatgtgga gaaaccggtc gtcttaccga
      421 ttcccccagc cttagcgcac acattaaatc agatagaata ttatatgaag gataaatact
      481 ttaccttgaa ttgagattaa aaatgtttca attcctgata aagcttttgc acaggtaatc
      541 ccatcacgtt ataaaagcta ccattgatag cctctacccc gatataaccg atccactcct
      601 gaatgccata ccctcccgct ttatcataag gtttatattt atccaaataa taattaatct
      661 cttcatcacc caattttgcg aaacaaaccg cagattcgac ggaaaagcct acatttttgt
      721 ccttcgtcat gatacaaacg ccggttatta cctgatgtac atgatccgac aaagcatgaa
      781 gcatagcata agcttcctcc cggttcgcag gcttccccat aaccccgtca aacgtccaaa
      841 cgatcgtatc tgccgtgatt agcaattcat catccgccat agtcgattta taggcctccg
      901 ctttcgaacg ggcaatatat aaagggatct ccatggagtc aatagaatcc gggtaagact
      961 cgtcaatatc cggaattatc ctcacctcga agtcgatatc cagaccagat aacaaattcc
     1021 gtcgtctcgg agaattagag gctaagacga tcttgtactt ttttaaattc tctaacataa
     1081 cctattcgat taagcgttac acattcacca aaattttacc acccaaaagc ctcctcgccg
     1141 aaccagtgtc cttgcgcccg catcgtttgc tcgatcacgt ccctagctac gccttcgcca
     1201 cctcgccggg aggatatata tttcgctatc tccttgatct ccggagccgc atccgcaggt
     1261 gccaccggca atccgactcg cgtcattacc tcataatcag gaatatcatc acccgcatac
     1321 atgatttgct caggagacaa gcccgttttt tccataaaat ccttaaagtc atgcaccttt
     1381 acagcgctac gcatataaat atgttgtatt cctaaacgag aaaagcgaat ctgtacggct
     1441 tccgtatatc cgcccgtaat tatagcgacc tcataacctt tcttcacggc caattgcaag
     1501 gcatagccat ccttgatatt gaccgtacgc atcggatcgc cattcgggtg aagcggaatc
     1561 acatcgcagg atagcacccc gtctacatca aagacaaaag cctttatttt tctcaaatca
     1621 tagtttatac tactcatgtc gagcctcctt atgtatactt cggctaatca gctcatatag
     1681 atttcgcata tccggatctt taagcatagc catatgtttg tttatcacat tctcgtcata
     1741 tcgtatagct ggtcccgttt gggctcgcgc cggcgacatt acatgtacct tagcggctgt
     1801 ctcgtctatc aaaggtagca agacctctcc cggtatttgc tgttcttcca agatcttttc
     1861 agctagcgca tacatatgat tcgtaaaatt acaagcgaaa accgccgcta aatgtaagtt
     1921 ctttcgcttc tcggaggaga ggaaacggac atcactggag agcgccctag ccacctctcc
     1981 cagcaccttc tcatcttcag acgagttcgc ctctaaaaag aacggtattt tcttgaaatc
     2041 cacctcccta ctcttactaa acgtttgtaa cgcataaacc accccatatc tagccgtaag
     2101 accttcaaat acagagattg gcatactccc tgccgtatgc acccacaaac cgttattcgg
     2161 ttttacacgg gcgataacat cttggagcac ggcatctttc aaagagaaaa catacaagtc
     2221 ggcatcttcc acaatatctt ccgggacaac agtccaccca catcccaatt catcggctaa
     2281 aatcttagca tgctcacttg tgtgactnnn nnnnnnngac tatacacttg cccgatactc
     2341 attccggact tacgcatttc caacgaaagc cgggtagcta agtttccagc accaacaaat
     2401 acgactctca ttcttccgcc tctttatttt cttccggaag agagaacttt cctatatgta
     2461 tcttctccca ttgtaaatgg gattcatcaa aaggcttacg aacctgatcc ttataaccga
     2521 taccaatgat agacaagaca tccaattgat aagggatatc cagcaacgaa cgaacataat
     2581 tattcgaatc cgcctcgtcc tctgttaccc ggttccggat ctgacaccag caactgccca
     2641 atcccaaatc ctccgcctgc aattgcatat aaatagaagc gaccgaagcg tcctcgatcc
     2701 aaacatcgct ttccatcaca ttcgccaaga caaccacggc caaggcacaa ccctccagaa
     2761 aagcagaacc atttttctta cacccggcaa gtttcttcaa catttcctta tcttccacga
     2821 ccacgaactg ccaaggatta ctacgttttg aggccggagc catcaacgcc gctttcaaga
     2881 tcagttctac ctgctcgggt gaaagtagtt gttcggtaaa cttacgtgta cttcttctat
     2941 tttgtataag tgttgcaaaa ctctccattt ttttcgttct ttgtactctt ttaatattaa
     3001 gattcgcaaa tataaatata attttttgca cccatatata cgtatcgttc ttttttctcg
     3061 ttagtatttt tataattgaa caatagatta tgaagattcg tgcgatagcc gcgctgctat
     3121 ttatacttat ttccgtgagt gcctttggcg aaggccgcat aaaaatcact ggttatgtcc
     3181 gtgacgccga cggtaaccct ctggaattag tgaatgtccg ggttaagaac acgttgatcg
     3241 gctccatgac caacgagaag ggatattatt ccttttccat atcgccgggg gattctatct
     3301 ccattattta ctcttgtctg ggatataata aggctgaacg tatcattccc tcggcacaag
     3361 ccgatatgcg cctgaacgta cagatgaact atacctcatt tgatttaggg gaagtatctg
     3421 ttactgccat ccgcaagcag accacgacca tggagtccct aaatgcggac aaaatcaagt
     3481 tattgcccga tccttccgga ggtagtatag agagcttggt cgttacgttt gccggagtat
     3541 cgtccaataa cgagttaagt tcccagtatt ccgtacgtgg aggtagttat gatgaaaata
     3601 tcgtttatgt gaatgggatc gaggtattcc gtccacttct gattcgctcg ggacaacaag
     3661 agggccttag ctttatcaat ccggacctaa cggaggcggt caatttcgcc gccggtggct
     3721 tcgaggcccg ttacggagac aagatgagtt ccgtgctgga tattacctat aaaaagccta
     3781 agatattcga aggctcagct tctgcgagct tgttgggtgc gaatgcttat gtaggcagtt
     3841 ctattggtaa atttacccaa gtaacgggtt tccgctttaa aagcggtcgg tctattttgg
     3901 gtaccatgga tacagacgct gaatacgacc ctaaatttat cgatctgcaa acttacatca
     3961 cgtaccaatt ggcccctaaa tgggaaatca atttcttggg aaacctcgct aacaataatt
     4021 ataaattcac cccttatagc cgggaaacct ctttcggtac agccgagcat cccaagaact
     4081 tcaaagtcta tttcgacgga agggaaagag accgtttcca aaccttattc ggtgcgctta
     4141 cattgaaaca caaccccaat gagaacacag agttgggact tcaagcctcc gctttcaaaa
     4201 gcaaggaaga agagggatac gatatcgccg gagaatattg gctgagcgag aacggagcgg
     4261 aaaatccgaa tgacgacgcg tcagccgcca tgtccgtagg ccgttatcac gagcacgcac
     4321 gaaaccgttt gaactccacc gtcatgaatg tcgggcacta tgggatggcc cgccttttaa
     4381 acaatacgtt gaaatgggga gccacggtac aaatggagaa aatcaatgat aagatcagtg
     4441 aatgggaaaa aagggattcc tcaggttatt ctttgcccca aaccggtaat aacgtaagtg
     4501 tatattcgaa cctcttttct gataatcaga tagaaagcac acgcttttcc gcttatgcgc
     4561 aagacgcatt caaattcagg accaagcaag gtctgttcac gttagtcgca ggggttagag
     4621 gtagttattg gacttataat aaggagttcc ttttcagtcc ccgtgcctca ttgggcttta
     4681 tcccgaactt cgaccaagac ttgacgctcc gtttcgccac cggactgtat tatcaatcgc
     4741 ccttctacaa ggaattacgt agagtagaca aagataagaa cggcaataat atcacggtat
     4801 tgaacaaaga tctaaagtca caacgctcca tccatttcat attgggagga gattatacgt
     4861 tccgtgccgt agaccggaat ttcaaggtga ccgccgagat gtactataaa aagctggaca
     4921 atctgaatcc ctacaccgta gataacgtca agatccgcta ttacggtgag aactgcgcca
     4981 aaggttacgc catgggactc gatgtcaaat tcttcggaga attcgtaccg ggtaccgact
     5041 catggatcag cttctccttg atgaaagccc agcaaaccat ccgggaaaca acgaccgttc
     5101 ctatggccaa tagccaaggc tacaacatct cactcttctt ccaagattat ttcccgggct
     5161 ataaacgagt caagctaaat ctgaaaggag ttctatccgg aggacttccc cagacaatcc
     5221 cgggcaaagg atacgaagcc ggctatttcc gtacgcccgc ctacaaacgt gtagatatcg
     5281 gcctctccta tcaattggca ggaggcacgg acgctatcat ggacaggggc ttcttccgcc
     5341 atttgaaaaa catttggcta ggtctggatg tatttaacat attagacatc aaaaacgtta
     5401 gttcctacta ttggataaca gatgtatata atgtccaata cgcagttcca aactatctga
     5461 ccggacgtca attgaacgtt cgtctgattg tcgattttta ataaaatgta tctttaaaca
     5521 catttactgg gagataaaaa caaaaaatta tttcctcatt cataaaaagt agtgtacatt
     5581 tgcacacaat agaaacaaac atttactaaa tctttaaatt attattgaca tggaacttac
     5641 acatatcgaa catttaggta tcgcagtgaa gagtatcgag gcttgtttac cctattatga
     5701 aggcgttctt ggattaaaat gctacaatat cgaagtagta gcagaccaaa aagtaaaaac
     5761 cgcatttttc aaggtaggac agactaagat tgaattacta gagccgacca gcgaagatag
     5821 cacgatcgca aaatttatcg agaaaaaagg tgaaggtatc caccatatcg cattcgcggt
     5881 acctgatgta caggcagctt tgaacgaggc tgaggaaaaa ggcgttaaat taatcgataa
     5941 agctccccgt ggtggcgcgg aaggcttgaa catcgctttc cttcacccga aatcaacttg
     6001 cagcgtattg acagagcttt gcatgccggg caacaaataa ttaatccgtt catttctaac
     6061 aacaaatcaa aatacaatga gtaaccagct tgaaaaagta aaagagctca tcgcacttcg
     6121 tgagcaagct cgcttaggtg gaggagagaa aagaatcgaa tcacagcaca aaaaaggcaa
     6181 atataccgct cgtgagcgta tcgccatgtt gcttgacgaa ggtagtttcg aggaattcga
     6241 catgtttgtt caacaccgtt gtacaaactt cggtatcgag aaaactaaat atttaggcga
     6301 tggtatcgta acaggttatg gtacgatcga cggacgtttg gtatatatct tcgctcaaga
     6361 tttcaccgta ttcggtggag ccttgtctga ggctttggct atgaagatct gtaaagtaat
     6421 ggatcaagcc atgaagatgg gcgctcccgt tatcggtttg aacgactccg gtggagctcg
     6481 tatccaagaa ggagtaaatg ccttggcagg atacgctgag attttccaac gtaacatctt
     6541 ggcttccggt gttgttcctc agatttccgg tatcttcggc ccttgcgccg gtggagccgt
     6601 ttattctccg gctttgacag acttcaacat catgacacgt ggtaccagct atatgttctt
     6661 gactggtccg aaagtcgtaa aaaccgtaac aggtgaggat gtaacccaag agcagttggg
     6721 tggagccagc gtacacacta ccaaatcggg tgtagcccat ttcgctgtcg atacagaaga
     6781 agatggtttg caattgattc gtaaattgct cagtttctta cctcagaaca acttagagga
     6841 aacgccgtta gttgagtgca aagacccgat cgatcgtctg gatgatgtat tgaacgatat
     6901 cattcccgat aacgccaacc aatcttacga tatgtatgag gttatcggta cgatcgtcga
     6961 taacaacgag ttcctagagg tccatgcgga ctacgctaag aatatcatcg taggtttcgc
     7021 tcgtttcaac ggacaatccg tcggtatcgt agctaaccag ccgaaggtta tggcaggatg
     7081 cttggatagc aacgcatctc gtaaagcagg tcgcttcgtt cgtttctgcg acgctttcaa
     7141 tattcctttg gtaacattgg ttgacgttcc gggattcctt ccgggcacag gtcaggaata
     7201 caacggtgta atccttcacg gcgctaaatt gctttacgct tatggtgagg ctaccgttcc
     7261 taagattacc gttacattgc gtaagtctta cggtggagct tattgcgtga tgagttctaa
     7321 acatttacgt ggtgatatga attacgcatg gccgacagcc gagatcgccg ttatgggccc
     7381 gagcggtgcc gtagaggtta tcttcgccaa ggaagtagca gccgctgaag atccgaaagc
     7441 atgcgcagca gagaaagaag ctgaatataa gaaagcattc gctaatcctt ataacgcagc
     7501 tcaatacggt tatatcgacg atgttatcga accgcgtaac actcgtttcc gtattattcg
     7561 tgctttacaa cagttgcaga ctaagaagtt aagcaatcct gctaagaaac atgacaatct
     7621 gcctctataa ttcttaaaac aggaaatgaa tatgattaat aagaaaatag gggtattgct
     7681 gctgtttgcc ttgctcgttt cattcggggc aaaagcacag cgcgctacct ccatgcgaat
     7741 aaatgaagtg ctggtcatca atgaggataa ctttgttgat gattacggca aacgccacgc
     7801 ttggatcgag ctgtataacg gctcggccgg ttcggttaat atcgccggtt gttttttgac
     7861 taacgacaaa aacaacccga aaaaatatcc gatcccgaag ggcgatgttc tgacagtcat
     7921 ccctcctcgc cagcatactt tgttctgggc agacggagaa cctaatcgcg gtacattcca
     7981 tgttaatttc actcttgacc catcaaaaga aaattacctt gcattatatg atgctgacgg
     8041 taaaactttg attgacgaga tcgttattcc ggcttcacaa aaagcggata tcagttttgg
     8101 tagaacgtta gacggacaag gagaatggac tattttgtca aaagttaccc ccagcaccaa
     8161 caacgtaaca ttggactcta acgagaaaat cgaaaacttt aaagaaaatg actcctgggg
     8221 tatcggtatg accttgactg ctatggcagt tgtattttcc gggttattcc tgctgtttat
     8281 catctttaaa caaatcggta aattctctat cgctgccagc aaacgtaatg cacagaaagc
     8341 tgccggggca gccgttgttg ctgacaatgc aggtcaggaa tccggagaga tctttgcggc
     8401 tatcggtgcg gctctgtatg aaatgagcga cgataaccac gatatcgaac acacggttct
     8461 tacgatccgc aaggttcaaa gatcttattc tccgtggagc tccaagattt acggtctgcg
     8521 tgaagttccc aaaaagtaat tatctctaaa aacaaacaag aatgaaaagt tttaaatata
     8581 ctattaacgg taacgtatat aaagtacata tcaactcggt agtagatgat atcgctgaag
     8641 tagaagtaaa cggtactccc tatcaagtaa aaatggagaa accggcaaaa aaacagatgg
     8701 ttacactgaa acgtccggcc caagctccta caacggcaag cggcgatcct gttgtttccc
     8761 gtccggtagc ctcgacaacc aaaggcgctg tcaaatctcc gctgccaggt gtaatcctgc
     8821 aggttaactg taaagtcggt gatgctgtca agagaggcca gaatctgctt gtcctcgaag
     8881 ccatgaagat ggaaaataac atcaacgccg accgtgacgg taaaatcatt gaaataaaag
     8941 taaacaaagg ggattccgta ctggaaggtg ctgacctcgt cgtaatagga taatattatg
     9001 ttaggatcag tattattaca ggcagtaggt gcgactcatg aaagttttct ccagttcctg
     9061 ggaaaaaacc ttgagttgtt cctcacatat acaggagtct acaacgcgac accgggtcac
     9121 atcatcatga tccttatcgg tctgttgttt atcttcctgg ctattaaata tgaattcgag
     9181 ccaatgctcc ttatccctat cggattcggt atcctgatcg gtaatattcc gttcaaagat
     9241 gcaggattgc aggtcggtat ctacgaacaa ggctccgtac tgaacatcct ctaccagggt
     9301 gtaacctccg gatggtatcc gccgttgatc ttcctcggta tcggggctat gaccgacttc
     9361 tccgccttga tctccaaccc taagttgatg ttgatcggtg cagctgctca gttcggtatc
     9421 ttcggtgctt atatcatcgc tcttcagatg ggattcgaac cgaaccaggc cggtgctatc
     9481 ggtatcatcg gtggtgctga cggcccgacg gctatcttcc tttcttccaa gctggctcca
     9541 aacctgatgg gtgctattgc ggtatcggcc tactcttata tggcgttggt tcctatcatc
     9601 cagccgccgt tcatgcgttt gctgactact cagaaagaac gtctgatccg tatgaaaccg
     9661 ccgagagccg tttcttctac ggaaaagatc gtcttcccga tcgtaggtct gttgctgact
     9721 tgcttcctgg ttccttccgg tctgcctctg ttgggtatgc tgttcttcgg aaacctgttg
     9781 aaagaaagtg gtgtaacgcg tcgtttggct gaaacagccc gcggtccgct gatcgataca
     9841 atcacgatcc tgttgggtat cacggtaggt gcttccactc aggctactca gttcctgaca
     9901 ttaaactcca tcaagatctt cggtctggga gctttgtcat tcgtgattgc tacttgcgca
     9961 ggtatcctgt tcgttaagtt cttcaacctg ttcttgaaag aaggtaacaa gatcaacccg
    10021 cttatcggta actccggtgt gtctgccgta cctgactccg cccgtatctc tcagaacgta
    10081 ggtctggaat atgatccgac caactacctg ttgatgcacg ctatgggtcc gaacgtagca
    10141 ggtgtaatcg gttctgccgt agcagccggt atcctgttgg gattcttagg ataatcgatt
    10201 tattctacat aaaaaaggct ccgcatcaaa tgatacggag ccttttttat atctattctt
    10261 atcagatatt ctgttctata gtcatcggat ccgtttcagg atttgcctcc tgttccaatg
    10321 tcgttccaaa aaacaaccag aacatcaaca ggataatagc aatcaccact ccaatgatca
    10381 gcagtacatt cgttttcttt cgtctcatgt ctattcttca attagtttga agataaaaca
    10441 agacaaaccc tcgtttggtt taacaagggt ttacttttgt ccgtgcgaaa tagtttagaa
    10501 aaatttagtt tcccaacacc ttattcttcg caaccgtcgc ctggaactct ttcagataga
    10561 acggttcgaa gtaagcggta tcttcgaacc tgccggcggc aaaggcttgt tctgccagcg
    10621 gaaccatgtt tacggcgagg ggatggatgt cttcgatgaa aatggcgttc ggagaagtga
    10681 tgaccggttt gcatttggaa gcaccgttac caacgaaaca aacgttgcct ttttccaggt
    10741 aagaagcata tgtgccggca tccacaatat cggcagccgt ctcgcggaca ggcttcaaag
    10801 atgcatcgta gatagcggca taaacctcca tccggcgggc atccagcatg gcgcaataga
    10861 ggcaaccgtc aatagcctta ttctctttaa tggcagtagc agctatgata tccaatgtat
    10921 gaataccgat cagaggaata ccgaaaccaa aacaaagacc tttagcaaca gacaccaaga
    10981 tacgcaagcc ggtataggaa ccaggaccgc tactgaccgc aacggcatcc agcttaccac
    11041 ctttctcttt cagcacggaa agagcttctt cgacaaatac gcctaacaag gcggcatgcg
    11101 aaggaccgtc gaatgaggcc ttctcaaaaa ggacttcacc gtccgtagac aacgctacag
    11161 aacaaacaga agtcgatgtt tcgatattta atatacagga cataattaat tgccaatctt
    11221 gattacggat acaaaagtat aaaaacataa ctgtaatcac atgatctaaa ttgattttat
    11281 taactatctt tgcaatctaa tttttagaac aatgatacaa tcaatgacag gattcggtaa
    11341 ggttacagcc gaactccctt ctaaaaaagt aaccgtagaa ataaaggctc tgaacagcaa
    11401 gcaactggat ttgtctaccc gtattccttc tgcctacaaa gaaaaagaga tgcaaatacg
    11461 aagtttgtta ctccagtcgc ttgaacgtgg aaaggtcgaa tttaatatat tcatcgagta
    11521 tattggtaaa gacacgccta cacagatcaa cctggctgcg gtggaaaatt actacactca
    11581 aatcaaagat attgccgaca aactaaacat cggacttccc gccgactggt tccagacatt
    11641 gctccgaatg ccggacgtga tcaagacgga agcccaggaa gtgaacgaag aggaatggaa
    11701 cgtggttgag aacgcaatca aagaagccat ccaacacctc tgcgatttcc gtatccagga
    11761 aggcgccatg ttgcaaaagt tgtttgagca gaaaatcgcc aatataggcc gcctgctttc
    11821 agaagttgaa ctctacgaaa aggaacggat cgaaaaggtc aaaacccgta tcatggacaa
    11881 cctcgaaaag attgccggac aggattacga caagaaccgc ttcgaacagg agatgatcta
    11941 ttacatcgaa aagttggatg taaacgaaga gaagaaccgc ttagacaatc atttgaaata
    12001 ctatatcagc acgatggaaa gcggacacgg acaaggtaaa aagctcggtt tcatcgccca
    12061 ggaaatggga cgtgagatca acaccctcgg ttcgaaaagc aaccatgccg agatgcaaaa
    12121 gatcgtcgtc cagatgaaag acgaactgga acagatcaaa gaacaagtat taaacgtatt
    12181 ataaaaccga tatatggctg gcaaactgat catattctcc gcaccgtcag gttcgggcaa
    12241 atcaactatc atcaatttcc tgctaaagca gaatctgaac ctgcatttct ccatctcggc
    12301 taccagccgg gccccgcgcg gaacggaaaa ggacggagtg gagtattatt tccttacgcc
    12361 agacgaattc cgcacacgta tcgcggcagg tgattttctg gaatacgaag aggtctatac
    12421 cgataaatat tacggtacac tgaaaagtga agtggaaaga cggctggtag gcggcgataa
    12481 cgtcatattc gatgtcgatg ttgtaggcgg ttgcaacatc aagaaatttt atggagaccg
    12541 tgccctgtcg gtctttatcc agcctccctc gatcgaagac ctgcgcagac gcctggaagg
    12601 acgtggcacg gatacttcgg aggtaatcga aagccgcatt gccaaagctg cgttcgaact
    12661 gggttttgcc gacaagtttg acgtaatcgt ggtgaacgac aaactggaaa cggcacaagc
    12721 agaagcattg aaagtgataa aagaatttct tgagaaagca tgaacggtaa gaaattatcc
    12781 aagaagtggc tatatacatt catcggtata gcatttgtcg ctcttgccac ttgtatagcc
    12841 gctttgtatt ataaggaata tatcattgca accggtaccg gtctggtatt cggtgcacag
    12901 gtcataaaca tcatcaagtg gaaacgggac tgaaagaaaa tacggcaggc aaacgtaaaa
    12961 ccggtattta ttcaggttcg ttcaatccgg ttcacatcgg ccacctggca ttagccaact
    13021 ggctatgtga attcacggaa ttggacgaaa tatggttctt gatcacccca cacaacccgc
    13081 taaaagagaa ggaagaattg atagacgacc gactccgcta cgagttggta aagaaatcca
    13141 ttgccggcta tcctaaattt aaagtcagcg atattgaatt ttcacttccc caacctacct
    13201 atacgatcga cacacttcgt acacttgatc ggctgtaccc cgaacgggag ttttatttta
    13261 ttatgggagc ggacaactgg acatcaatca gccgctggaa agaatccgaa acaatcatag
    13321 ccaactatcc gatcctgatc tatccgcgta aaggatatga agtaaagcta aacaacagta
    13381 tgccgcatat acgttatgta gaggctccgc aaatcgaagt atcttctacc ttcatccgcc
    13441 agtcgctccg gacaggcaaa gacgtacgct ttttcctgcc ggaagccatc cgcgacatat
    13501 tacaacatta acagcctcat cttcaaagca tctccaatct gttgtttcaa cattttagca
    13561 tttaacggtt ttgccgcata gccgtcaaaa ccactatcca taatct
//
